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624 results on '"Holtzman, J."'

602. The temperature dependence of the components of the hepatic microsomal mixed-function oxidases.

Author

Holtzman JL and Carr ML

Subjects
Aniline Compounds pharmacology, Animals, Chemical Phenomena, Chemistry, Physical, Cytochromes, Enzyme Activation, Kinetics, Male, Mathematics, Microsomes, Liver drug effects, Models, Chemical, Morphinans pharmacology, NADP, Rats, Temperature, Microsomes, Liver enzymology, Mixed Function Oxygenases, Oxidoreductases antagonists & inhibitors
Published
1972
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604. Hepatic drug metabolism and protein malnutrition.

Author

Rumack BH, Holtzman J, and Chase HP

Subjects
Aniline Compounds, Animals, Body Weight, Cytochrome P-450 Enzyme System metabolism, Cytochrome Reductases metabolism, Cytochromes metabolism, Female, Flavin Mononucleotide metabolism, Flavin-Adenine Dinucleotide metabolism, Haplorhini, Heme metabolism, Kinetics, Liver enzymology, Macaca, Methyltransferases metabolism, Microsomes, Liver enzymology, Mixed Function Oxygenases metabolism, Morphinans, Organ Size, Phospholipids metabolism, Riboflavin metabolism, Dietary Proteins, Liver metabolism, Microsomes, Liver metabolism, Protein Deficiency metabolism
Published
1973

605. Effect of 4,4-dideuteration of reduced nicotinamide-adenine dinucleotide phosphate on the mixed function oxidases of hepatic microsomes.

Author

Holtzman JL

Subjects
Adenine Nucleotides, Aniline Compounds, Animals, Carbon Monoxide, Deuterium, Electron Transport, Electron Transport Complex IV metabolism, Glucosephosphate Dehydrogenase metabolism, Hexokinase metabolism, Kinetics, Male, Mixed Function Oxygenases metabolism, Morphinans, NADP, Oxidoreductases metabolism, Oxygen Consumption, Rats, Microsomes, Liver enzymology, NAD metabolism
Published
1970
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606. Inelastic laser light scattering and particle size of detergent-treated microsomes.

Author

Holtzman JL, Erickson RR, Dewan RK, and Bloomfield VA

Subjects
Animals, Cholic Acids pharmacology, Chromatography, DEAE-Cellulose, Cytochrome P-450 Enzyme System analysis, Cytochrome Reductases analysis, Deoxycholic Acid pharmacology, Lasers, Liver drug effects, Macromolecular Substances, Male, Rats, Scattering, Radiation, Ultrafiltration, Bile Acids and Salts pharmacology, Microsomes, Liver drug effects, Mitochondria, Liver drug effects
Published
1973
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607. The effect of phenobarbital on the turnover of microsomal phospholipid in male and female rats.

Author

Holtzman JL and Gillette JR

Subjects
Animals, Depression, Chemical, Female, Male, Microsomes drug effects, Microsomes enzymology, Mixed Function Oxygenases metabolism, Phosphates metabolism, Phospholipids biosynthesis, Phosphorus Isotopes, Rats, Sex Factors, Stimulation, Chemical, Time Factors, Liver metabolism, Microsomes metabolism, Phenobarbital pharmacology, Phospholipids metabolism
Published
1968

609. The metabolism of 2-fluorobenzoic acid. II. Studies with 18-O2.

Author

Milne GW, Goldman P, and Holtzman JL

Subjects
Catechols biosynthesis, Chromatography, Gas, Oxygen Isotopes, Peroxides metabolism, Spectrum Analysis, Benzoates metabolism, Fluorine metabolism, Oxygen metabolism, Pseudomonas metabolism
Published
1968

611. The distribution of the components of mixed-function oxidase between the rough and the smooth endoplasmic reticulum of liver cells.

Author

Holtzman JL, Gram TE, Gigon PL, and Gillette JR

Subjects
Aniline Compounds metabolism, Animals, Cytochromes metabolism, In Vitro Techniques, Male, Microsomes enzymology, Morphinans metabolism, Rabbits, Rats, Endoplasmic Reticulum enzymology, Liver enzymology, Oxidoreductases analysis
Abstract

Mixed-function oxidase activity, when measured by the N-demethylation of ethylmorphine or the hydroxylation of aniline, is significantly higher in the smooth hepatic endoplasmic reticulum than in the rough. In the rabbit the smooth membrane/rough membrane activity ratios are significantly greater than 1 whether the activities are expressed per g. of liver (ratio 5), per mg. of protein (ratio 3-5), per mug. of phospholipid phosphorus (ratio 2), per unit of cytochrome P-450 (ratio 1.7) or per unit of NADPH-cytochrome c reductase activity (ratio 2). On the other hand, if the activities are normalized to the NADPH-cytochrome P-450 reductase, there is no significant difference between the rough and smooth membranes. These results suggest that, in the rabbit, the rate-limiting step is the reduction of cytochrome P-450. In contrast, in the rat the difference in activities can be explained by differences in the concentration of cytochrome P-450.

Published
1968
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612. Estimation of pentobarbital hydroxylase activity by gas-liquid chromatography.

Author

Holtzman JL and Alberts DS

Subjects
Alcohols isolation & purification, Animals, Chromatography, Gas, Chromatography, Thin Layer, Female, Male, Mass Spectrometry, Mathematics, Methods, Pentobarbital isolation & purification, Rats, Rats, Inbred Strains, Stereoisomerism, Liver enzymology, Microsomes, Liver enzymology, Mixed Function Oxygenases analysis
Published
1971
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613. Inhibition by deuterated water of the mixed-function oxidases of hepatic microsomes of the male rat.

Author

Holtzman JL and Carr ML

Subjects
Aniline Compounds, Animals, Benzopyrenes, Chemical Phenomena, Chemistry, Physical, Cytochrome P-450 Enzyme System, Cytochrome c Group, Dihydrolipoamide Dehydrogenase antagonists & inhibitors, Hydrogen-Ion Concentration, Kinetics, Male, Microsomes, Liver drug effects, Mixed Function Oxygenases antagonists & inhibitors, Morphinans pharmacology, NADP, Oxidoreductases, N-Demethylating antagonists & inhibitors, Rats, Time Factors, Deuterium, Microsomes, Liver enzymology, Oxidoreductases antagonists & inhibitors
Published
1972

614. Effect of dietary orotic acid and adenine sulfate on hepatic microsomal enzymes in male and female rats.

Author

Holtzman JL and Gillette JR

Subjects
Aniline Compounds metabolism, Animals, Cytochromes metabolism, Diet, Female, Formaldehyde analysis, Male, Morphinans metabolism, Phenols analysis, Rats, Sex Factors, Uracil Nucleotides pharmacology, Adenine pharmacology, Liver enzymology, Microsomes enzymology, Mixed Function Oxygenases metabolism, Orotic Acid pharmacology, Oxidoreductases metabolism
Published
1969
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615. Growth of rats fed chlortetracycline or an exhange resin.

Author

Holtzman JL and Visek WJ

Subjects
Ammonia metabolism, Animals, Body Weight, Intestinal Absorption, Intestinal Mucosa metabolism, Male, Rats, Urea metabolism, Chlortetracycline pharmacology, Diet, Digestive System metabolism, Growth drug effects, Ion Exchange Resins pharmacology
Published
1965
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617. Kinetics and inelastic light-scattering studies of the role of phospholipids in the microsomal membrane structure.

Author

Holtzman JL, Erickson RR, Gram TE, Dewan RK, and Bloomfield VA

Subjects
Animals, Carbon Radioisotopes, Cytochrome P-450 Enzyme System, Cytochrome Reductases analysis, Cytological Techniques, Kinetics, Male, Membranes metabolism, Microscopy, Electron, Microsomes, Liver metabolism, Oxidoreductases analysis, Phosphates metabolism, Phosphorus Radioisotopes, Proteins metabolism, Rats, Spectrophotometry, Stearic Acids metabolism, Tritium, Microsomes metabolism, Phospholipids metabolism
Published
1973

619. The oxidation of N,N'-bis(4-aminophenyl)-N,N'-dimethylethylenediamine (BED) by rat liver.

Author

Holtzman JL and Seligman AM

Subjects
Aniline Compounds metabolism, Animals, Centrifugation, Density Gradient, Cytosol enzymology, Detergents pharmacology, Dimethylamines metabolism, Electron Spin Resonance Spectroscopy, Formaldehyde pharmacology, Histocytochemistry, Hydrogen-Ion Concentration, Kinetics, Microscopy, Electron, Microsomes, Liver enzymology, Mitochondria, Liver enzymology, Monoamine Oxidase metabolism, Organ Specificity, Oxidation-Reduction, Oxidoreductases metabolism, Oxygen Consumption, Rats, Spectrophotometry, Spectrophotometry, Ultraviolet, Subcellular Fractions enzymology, Xanthine Oxidase metabolism, Ethylenediamines metabolism, Liver enzymology
Published
1973
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620. Kinetic studies on the control of ethylmorphine N-demethylase. The role of ethylmorphine activation of reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase.

Author

Holtzman JL and Rumack BH

Subjects
Animals, Binding Sites, Cytochrome P-450 Enzyme System, Enzyme Activation, Female, Kinetics, Male, Microsomes, Liver enzymology, Protein Binding, Rats, Sex Factors, Spectrophotometry, Spectrophotometry, Ultraviolet, Morphinans pharmacology, Oxidoreductases metabolism, Oxidoreductases, N-Demethylating metabolism
Published
1973
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621. Iron species of hepatic microsomes from control and phenobarbital-treated rats.

Author

Montgomery MR, Clark C, and Holtzman JL

Subjects
Animals, Calcium, Chromatography, Affinity, Cytochrome P-450 Enzyme System metabolism, Cytochromes metabolism, Heme metabolism, Horses immunology, Male, Metalloproteins metabolism, Microsomes, Liver drug effects, Potassium Chloride, Rats, Sulfur, Time Factors, Ultracentrifugation, Ferritins metabolism, Iron metabolism, Microsomes, Liver metabolism, Phenobarbital pharmacology
Published
1974
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622. Metabolism of drugs by isolated hepatocytes.

Author

Holtzman JL, Rothman V, and Margolis S

Subjects
Animals, Blood, Cattle, Cytochromes metabolism, Hyaluronoglucosaminidase pharmacology, Liver cytology, Liver drug effects, Liver enzymology, Male, Microbial Collagenase pharmacology, Mixed Function Oxygenases, Rats, Subcellular Fractions enzymology, Subcellular Fractions metabolism, Time Factors, Aniline Compounds metabolism, Benzopyrenes metabolism, Cells metabolism, Liver metabolism, Morphinans metabolism
Published
1972
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624. Inhibition of hepatic microsomal mixed function oxidases by D2O.

Author

Holtzman JL and Carr ML

Subjects
Animals, Hydrogen-Ion Concentration, In Vitro Techniques, Male, Microsomes, Liver drug effects, Morphinans pharmacology, NADP metabolism, Rats, Deuterium pharmacology, Hydrolases antagonists & inhibitors, Microsomes, Liver enzymology, Oxidoreductases antagonists & inhibitors, Transferases antagonists & inhibitors
Published
1970
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