901. Synthesis and activity of a newly isolated analgesic pentapeptide, neo-kyotorphin
- Author
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Nobuyuki Kawai, Tadashi Akita, Kouki Kitagawa, Hiroshi Takagi, Kiyoshi Fukui, Hiro Amano, and Yoshiaki Kiso
- Subjects
chemistry.chemical_classification ,Analgesics ,Stereochemistry ,Guinea Pigs ,Analgesic ,Liquid phase ,Peptide ,General Chemistry ,General Medicine ,In Vitro Techniques ,Pentapeptide repeat ,Kyotorphin ,Mice ,chemistry.chemical_compound ,chemistry ,Bovine brain ,Drug Discovery ,Peptide synthesis ,Animals ,Endorphins ,Muscle Contraction - Abstract
A newly isolated bovine brain pentapeptide, Thr-Ser-Lys-Tyr-Arg (neo-kyotorphin), which contains the Tyr-Arg (kyotorphin) unit at its carboxyl terminal portion, was synthesized by using the TFMSA-TFA-thioanisole deprotecting procedure. The synthetic peptide exhibited dosedependent analgesic activity in mice at a level approximately equal to that of Leu-enkephalin.
- Published
- 1983
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