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Your search keyword '"A. N. Kozitsina"' showing total 53 results
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53 results on '"A. N. Kozitsina"'

51. Catalytic systems based on the organic nickel(ii) complexes in chronoamperometric determination of urea and creatinine

Author

G. L. Rusinov, Zh. V. Shalygina, A. N. Kozitsina, Egor V. Verbitskiy, S. G. Tolshchina, S. S. Dedeneva, and Kh. Z. Brainina

Subjects
Detection limit, Nickel, chemistry.chemical_compound, chemistry, Inorganic chemistry, Urea, chemistry.chemical_element, General Chemistry, Chronoamperometry, Electrochemistry, Electrocatalyst, Voltammetry, Catalysis
Abstract

The organic nickel(ii) complexes with catalytic activity in the electrochemical oxidation of creatinine and urea were synthesized and studied. The signals of electrocatalytic oxidation of the studied carbonyl-containing amines in model solutions were obtained. The detection limit (by the 3σ-criterion) is 8.7·10−6 and 2.7·10−5 mol L−1 for urea and creatinine, respectively.

Published
2009

52. Some peculiarities of pulmonary clearance mechanisms in rats after intratracheal instillation of magnetite (Fe3O4) suspensions with different particle sizes in the nanometer and micrometer ranges: are we defenseless against nanoparticles?

Author

Boris, Katsnelson, Larissa I, Privalova, Sergey V, Kuzmin, Tamara D, Degtyareva, Marina P, Sutunkova, Olga S, Yeremenko, Ilzira A, Minigalieva, Ekaterina P, Kireyeva, Mark Y, Khodos, Alisa N, Kozitsina, Natalya A, Malakhova, Julia A, Glazyrina, Vladimir Y, Shur, Eugene I, Shishkin, and Ekaterina V, Nikolaeva

Subjects
Phagocytosis, Neutrophils, Macrophages, Alveolar, Animals, Female, Particle Size, Magnetite Nanoparticles, Bronchoalveolar Lavage Fluid, Ferric Compounds, Lung, Rats
Abstract

We studied differences between phagocytic responses to nanoparticles (NPs) versus microparticles in the pulmonary region by synthesizing magnetite of different sizes and instilling suspensions of these particles intratracheally into rats' lungs. Ten and 50 nm particles caused a greater increase in cell counts of the bronchoalveolar lavage fluid (BALF) than the instillation of microparticles. The response to 10 nm particles was weaker than to 50 nm ones, and the smaller NPs were more cytotoxic; both were more cytotoxic than the microparticles. Phagocytic activity was also studied using optical and atomic force microscopy. Phagocytes were more "loaded" in the lungs instilled with 10 nm particles as compared with those instilled with 50 nm particles; NPs of both sizes were engulfed more avidly than microparticles. We found in a separate comparative experiment that magnetite NPs were more cytotoxic than titanium dioxide and quartz suspensions having particle size distribution typical of industrial dusts.

Published
2011

53. Electrochemical immunosensor for Forest-Spring encephalitis based on protein A labeled with colloidal gold

Author

Jakov Beikin, A. N. Kozitsina, and Khiena Z. Brainina

Subjects
Biosensing Techniques, Biochemistry, Antibodies, Analytical Chemistry, Antigen-Antibody Reactions, Blood serum, Antigen, medicine, Electrochemistry, Humans, Staphylococcal Protein A, Voltammetry, Electrodes, Detection limit, Immunoassay, Chromatography, medicine.diagnostic_test, biology, Chemistry, Encephalitis Viruses, Colloidal gold, Electrode, biology.protein, Gold, Protein A, Oxidation-Reduction, Encephalitis, Tick-Borne
Abstract

An electrochemical immunosensor for diagnosis of Forest-Spring encephalitis has been proposed. It comprises a screen-printed thick-film graphite electrode serving as the transducer and a layer of the Forest-Spring encephalitis antigen immobilized on the electrode and functioning as the biorecognition substance. The procedure includes formation of an antigen-antibody immune complex, localization of colloidal gold-labeled protein A on the complex, and recording of gold oxidation voltammogram, which provides information about the presence and the concentration of antibodies in blood serum. The response is proportional to the concentration of antibodies over the interval from 10(-7) to 10(-2) mg mL(-1). The detection limit is 10(-7) mg mL(-1).

Published
2002

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