51. Effects of chloroquine and primaquine on rat liver cytosolic N-acetyltransferase activity.
- Author
-
Svensson CK, Drobitch RK, and Tomilo M
- Subjects
- Acetyltransferases antagonists & inhibitors, Acetyltransferases metabolism, Animals, Kinetics, Liver enzymology, Male, Procainamide metabolism, Rats, Rats, Inbred Strains, Acetyltransferases drug effects, Chloroquine pharmacology, Cytosol enzymology, Liver ultrastructure, Primaquine pharmacology
- Abstract
Chloroquine caused only slight reductions in NAT activity when added in vitro, and had no detectable influence when animals were pretreated with it for 4 days. This would suggest that the previously reported reduced excretion of acetylated metabolites of INH and SDD following chloroquine pretreatment is not the result of inhibition of NAT. In contrast, we found that primaquine significantly (P less than 0.05) reduced NAT activity when added in vitro, suggesting the need for further study with this agent.
- Published
- 1991
- Full Text
- View/download PDF