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51. Saliva Alternative to Upper Respiratory Swabs for SARS-CoV-2 Diagnosis

Author

Byrne, Rachel L., Kay, Grant A., Kontogianni, Konstantina, Aljayyoussi, Ghaith, Brown, Lottie, Collins, Andrea M., Cuevas, Luis E., Ferreira, Daniela M., Fletcher, Tom, Fraser, Alice J., Garrod, Gala, Hill, Helen, Hughes, Grant L., Menzies, Stefanie, Mitsi, Elena, Owen, Sophie I., Patterson, Edward I., Todd, Stacy, Williams, Christopher T., Hyder-Wright, Angela, Adams, Emily R., and Cubas-Atienzar, Ana I.

Subjects
Polymerase chain reaction -- Usage, COVID-19 -- Diagnosis, Salivary diagnostics -- Methods, Health
Abstract

Quantitative reverse transcription PCR (qRTPCR) is the diagnostic standard for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease (COVID-19) (1). Testing usually is conducted on [...]

Published
2020
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52. Molecular surveillance reveals widespread colonisation by carbapenemase and extended spectrum beta-lactamase producing organisms in neonatal units in Kenya and Nigeria

Author

Edwards, Thomas, primary, Williams, Christopher T, additional, Olwala, Macrine, additional, Andang’o, Pauline, additional, Otieno, Walter, additional, Nalwa, Grace N, additional, Akindolire, Abimbola, additional, Cubas-Atienzar, Ana I, additional, Ross, Toby, additional, Tongo, Kemi, additional, Adams, Emily R, additional, Nabwera, Helen, additional, and Allen, Stephen, additional

Published
2022
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53. Analytical evaluation of thirty-two SARS-CoV-2 lateral flow antigen tests demonstrates sensitivity remains with the SARS-CoV-2 Gamma lineage

Author

Kontogianni, Konstantina, primary, Bengey, Daisy, additional, Wooding, Dominic, additional, Buist, Kate, additional, Greenland-Bews, Caitlin, additional, Williams, Christopher T., additional, de Vos, Margaretha, additional, Escadafal, Camille, additional, Adams, Emily R., additional, Edwards, Thomas, additional, and Cubas-Atienzar, Ana I., additional

Published
2021
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54. Co-infections with chikungunya and dengue viruses, Guatemala, 2015

Author

Edwards, Thomas, Signor, Leticia del Carmen Castillo, Williams, Christopher, Donis, Evelin, Cuevas, Luis E., and Adams, Emily R.

Subjects
Infection -- Health aspects, Disease transmission -- Health aspects, Dengue viruses -- Health aspects, Health, Pan American Health Organization
Abstract

Chikungunya virus (CHIKV) and dengue virus (DENV) are arboviruses currently circulating in Southeast Asia, Central and West Africa, the Pacific islands, and the Americas, and their transmission can occur simultaneously [...]

Published
2016
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58. Streptococcus pneumoniae colonisation associates with impaired adaptive immune responses against SARS-CoV-2

Author

Mitsi, Elena, primary, Reiné, Jesús, additional, Urban, Britta C, additional, Solórzano, Carla, additional, Nikolaou, Elissavet, additional, Hyder-Wright, Angela D., additional, Pojar, Sherin, additional, Howard, Ashleigh, additional, Hitchins, Lisa, additional, Glynn, Sharon, additional, Farrar, Madlen, additional, Liatsikos, Konstantinos, additional, Collins, Andrea M, additional, Walker, Naomi F, additional, Hill, Helen, additional, German, Esther L, additional, Cheliotis, Katerina S, additional, Byrne, Rachel L, additional, Williams, Christopher T., additional, Cubas-Atienzar, Ana I, additional, Flecher, Tom, additional, Adams, Emily R, additional, Draper, Simon J, additional, Pulido, David, additional, Beavon, Rohini, additional, Theilacker, Christian, additional, Begier, Elizabeth, additional, Jodar, Luis, additional, Gessner, Bradford D, additional, and Ferreira, Daniela M, additional

Published
2021
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59. Prevalence of neutralising antibodies against SARS-CoV-2 in acute infection and convalescence: A systematic review and meta-analysis

Author

Savage, Helen R., primary, Santos, Victor S., additional, Edwards, Thomas, additional, Giorgi, Emanuele, additional, Krishna, Sanjeev, additional, Planche, Timothy D., additional, Staines, Henry M., additional, Fitchett, Joseph R. A., additional, Kirwan, Daniela E., additional, Cubas Atienzar, Ana I., additional, Clark, David J., additional, Adams, Emily R., additional, and Cuevas, Luis E., additional

Published
2021
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60. Lateral flow antigen tests can sensitively detect live cultured virus of the SARS-CoV-2 B1.1.7 lineage

Author

Kontogianni, Konstantina, primary, Cubas-Atienzar, Ana I., additional, Wooding, Dominic, additional, Buist, Kate, additional, Thompson, Caitlin R., additional, Williams, Christopher T., additional, Baldwin, Lisa, additional, Escadafal, Camille, additional, Sacks, Jilian A., additional, Adams, Emily R., additional, and Edwards, Thomas, additional

Published
2021
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61. ChloS-HRM, a novel assay to identify chloramphenicol-susceptible Escherichia coli and Klebsiella pneumoniae in Malawi

Author

Williams, Christopher T, Musicha, Patrick, Feasey, Nicholas A, Adams, Emily R, and Edwards, Thomas

Subjects
Klebsiella pneumoniae, Malawi, Chloramphenicol, Genes, Bacterial, Escherichia coli, Humans, Public Health Surveillance, Microbial Sensitivity Tests, Sensitivity and Specificity, Escherichia coli Infections, Original Research, Klebsiella Infections
Abstract

Objectives:Chloramphenicol is a broad-spectrum antimicrobial widely available in sub-Saharan Africa. With susceptibility re-emerging among Enterobacteriaceae in Blantyre, Malawi, we designed and evaluated a new high-resolution melt (HRM) RT-PCR assay, ChloS-HRM, to identify chloramphenicol-susceptible infections in a hospital setting. Methods:Seventy-two previously whole-genome sequenced isolates of Escherichia coli and Klebsiella pneumoniae from the Queen Elizabeth Central Hospital, Malawi, were subjected to determination of chloramphenicol MICs. Primers were designed to detect 18 chloramphenicol resistance genes that produce seven distinct peaks correlating with different gene groups (catA1, catA2, catA3, catB2, catB group 3, cmlA and floR) following HRM analysis. ChloS-HRM results were compared with MIC and WGS results. Results:ChloS-HRM correctly identified 15 of 17 phenotypically susceptible isolates and 54 of 55 resistant isolates, giving an accuracy of 88% in identifying susceptibility and 98% in identifying resistance. WGS identified 16 of 17 susceptible and 54 of 55 resistant isolates, giving an accuracy of 94% in identifying susceptibility and 98% in identifying resistance. The single false-susceptible result had no detectable gene by ChloS-HRM or WGS. Compared with WGS, ChloS-HRM had 100% sensitivity and specificity for catA (catA1-3), cmlA and floR, and 96% specificity for catB; sensitivity could not be estimated due to the lack of catB in the clinical sample collection. The overall agreement between MIC and HRM was 96% and between MIC and WGS it was 97%. Conclusions:ChloS-HRM could support antimicrobial stewardship in enabling de-escalation from third-generation cephalosporins by identifying chloramphenicol-susceptible infections. This would be valuable in areas with chloramphenicol-susceptible MDR and XDR Enterobacteriaceae.

Published
2019

63. A prospective diagnostic evaluation of accuracy of self-taken and healthcare worker-taken swabs for rapid COVID-19 testing.

Author

Savage, Helen R., Finch, Lorna, Body, Richard, Watkins, Rachel L., Hayward, Gail, Cook, Eloïse, Cubas-Atienzar, Ana I., Cuevas, Luis E., MacPherson, Peter, and Adams, Emily R.

Subjects
MEDICAL personnel, COVID-19 testing, POINT-of-care testing, DIAGNOSIS methods, MEDICAL care
Abstract

Background: Rapid diagnostic tests (RDTs) developed for point of care detection of SARS-CoV-2 antigen are recommended by WHO to use trained health care workers to collect samples. We hypothesised that self-taken samples are non-inferior for use with RDTs to diagnose COVID-19. We designed a prospective diagnostic evaluation comparing self-taken and healthcare worker (HCW)-taken throat/nasal swabs to perform RDTs for SARS-CoV-2, and how these compare to RT-PCR. Methods: Eligible participants 18 years or older with symptoms of COVID-19. 250 participants recruited at the NHS Test and Trace drive-through community PCR testing site (Liverpool, UK); one withdrew before analysis. Self-administered throat/nasal swab for the Covios® RDT, a trained HCW taken throat/nasal sample for PCR and HCW comparison throat/nasal swab for RDT were collected. RDT results were compared to RT-PCR, as the reference standard, to calculate sensitivity and specificity. Findings: Seventy-five participants (75/249, 30.1%) were positive by RT-PCR. RDTs with self-taken swabs had a sensitivity of 90.5% (67/74, 95% CI: 83.9–97.2), compared to 78.4% (58/74, 95% CI: 69.0–87.8) for HCW-taken swabs (absolute difference 12.2%, 95% CI: 4.7–19.6, p = 0.003). Specificity for self-taken swabs was 99.4% (173/174, 95% CI: 98.3–100.0), versus 98.9% (172/174, 95% CI: 97.3–100.0) for HCW-taken swabs (absolute difference 0.6%, 95% CI: 0.5–1.7, p = 0.317). The PPV of self-taken RDTs (98.5%, 67/68, 95% CI: 95.7–100.0) and HCW-taken RDTs (96.7%, 58/60, 95% CI 92.1–100.0) were not significantly different (p = 0.262). However, the NPV of self-taken swab RDTs was significantly higher (96.1%, 173/180, 95% CI: 93.2–98.9) than HCW-taken RDTs (91.5%, 172/188, 95% CI 87.5–95.5, p = 0.003). Interpretation: In conclusion, self-taken swabs for COVID-19 testing offer an accurate alternative to healthcare worker taken swabs for use with RDTs. Our results demonstrate that, with no training, self-taken throat/nasal samples can be used by lay individuals as part of rapid testing programmes for symptomatic adults. This is especially important where the lack of trained healthcare workers restricts access to testing. [ABSTRACT FROM AUTHOR]

Published
2022
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64. Accuracy of the Mologic COVID-19 rapid antigen test: a prospective multi-centre analytical and clinical evaluation

Author

Cubas-Atienzar, Ana I, primary, Bell, Fiona, additional, Byrne, Rachel L., additional, Buist, Kate, additional, Clark, David J., additional, Cocozza, Michael, additional, Collins, Andrea M., additional, Cuevas, Luis E., additional, Duvoix, Annelyse, additional, Easom, Nicholas, additional, Edwards, Thomas, additional, Ferreira, Daniella M., additional, Fletcher, Tom, additional, Groppelli, Elisabetta, additional, Hyder-Wright, Angela, additional, Kadamus, Ewelina, additional, Kirwan, Daniela E., additional, Kontogianni, Konstantina, additional, Krishna, Sanjeev, additional, Kluczna, Diana, additional, Mark, Julian, additional, Mensah-Kane, Josephine, additional, Miller, Elisha, additional, Mitsi, Elena, additional, Norton, Donna, additional, O'Connor, Emma, additional, Owen, Sophie I., additional, Planche, Tim, additional, Shelley, Samuel, additional, Staines, Henry M., additional, Tate, David, additional, Thompson, Caitlin R., additional, Walker, Gemma, additional, Williams, Christopher T., additional, Wooding, Dominic, additional, Fitchett, Joseph R. A., additional, and Adams, Emily R., additional

Published
2021
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65. Detection of SARS-CoV-2 infection by saliva and nasopharyngeal sampling in frontline healthcare workers: an observational cohort study

Author

Walker, Naomi F., primary, Byrne, Rachel L., additional, Howard, Ashleigh, additional, Nikolaou, Elissavet, additional, Farrar, Madlen, additional, Glynn, Sharon, additional, Cheliotis, Katerina S., additional, Cubas Atienzar, Ana I., additional, Davies, Kelly, additional, Reine, Jesus, additional, Rashid-Gardner, Zalina, additional, German, Esther L., additional, Solórzano, Carla, additional, Blandamer, Tess, additional, Hitchins, Lisa, additional, Myerscough, Christopher, additional, Gessner, Brad, additional, Biegner, Elizabeth, additional, Collins, Andrea M., additional, Beadsworth, Mike, additional, Todd, Stacy, additional, Hill, Helen, additional, Houlihan, Catherine F., additional, Nastouli, Eleni, additional, Adams, Emily R., additional, Mitsi, Elena, additional, and Ferreira, Daniela M., additional

Published
2021
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66. Evaluation of Loopamp™ Leishmania Detection Kit and Leishmania Antigen ELISA for Post-Elimination Detection and Management of Visceral Leishmaniasis in Bangladesh

Author

Hossain, Faria, primary, Picado, Albert, additional, Owen, Sophie I., additional, Ghosh, Prakash, additional, Chowdhury, Rajashree, additional, Maruf, Shomik, additional, Khan, Md. Anik Ashfaq, additional, Rashid, Md. Utba, additional, Nath, Rupen, additional, Baker, James, additional, Ghosh, Debashis, additional, Adams, Emily R., additional, Duthie, Malcolm S., additional, Hossain, Md. Sakhawat, additional, Basher, Ariful, additional, Nath, Proggananda, additional, Aktar, Fatima, additional, Cruz, Israel, additional, and Mondal, Dinesh, additional

Published
2021
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67. A novel magnetic bead-based extraction method for the isolation of antimicrobial resistance genes with a case study in river water in Malawi

Author

Byrne, Rachel L., primary, Cocker, Derek, additional, Alyayyoussi, Ghaith, additional, Mphasa, M., additional, Charles, Mary, additional, Mandula, Tamandani, additional, Williams, Christopher T., additional, Rigby, Jonathan, additional, Hearn, Jack, additional, Feasey, Nicholas, additional, Adams, Emily R., additional, and Edwards, Thomas, additional

Published
2021
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68. Immunoglobulin-G Enzyme-Linked Immunosorbent Assay Predicts Neutralising Antibody Response in Convalescent SARS-CoV-2 Patients

Author

Kay, Grant A, primary, Owen, Sophie I, additional, Giorgi, Emanuele, additional, Williams, Christopher T, additional, Menzies, Stefanie, additional, Clark, David J, additional, Cuevas, Luis, additional, Davies, Benedict M O, additional, Eckersley, Nicholas M, additional, Hughes, Grant L, additional, Kirwan, Daniela E, additional, Krishna, Sanjeev, additional, Patterson, Edward I, additional, Planche, Tim, additional, Staines, Henry M, additional, and Adams, Emily R, additional

Published
2021
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69. Limit of detection in different matrices of nineteen commercially available rapid antigen tests for the detection of SARS-CoV-2

Author

Kontogianni, Konstantina, primary, Edwards, Thomas, additional, Wooding, Dominic, additional, Buist, Kate, additional, Thompson, Caitlin R., additional, Williams, Christopher T., additional, Patterson, Edward I, additional, Hughes, Grant, additional, Baldwin, Lisa, additional, Escadafal, Camille, additional, Sacks, Jilian A., additional, Adams, Emily R., additional, and Atienzar, Ana I Cubas, additional

Published
2021
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70. Limit of detection in different matrices of nineteen commercially available rapid antigen tests for the detection of SARS-CoV-2

Author

Cubas-Atienzar, Ana I., primary, Kontogianni, Konstantina, additional, Edwards, Thomas, additional, Wooding, Dominic, additional, Buist, Kate, additional, Thompson, Caitlin R., additional, Williams, Christopher T., additional, Patterson, Edward I, additional, Hughes, Grant, additional, Baldwin, Lisa, additional, Escadafal, Camille, additional, Sacks, Jilian A., additional, and Adams, Emily R., additional

Published
2021
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71. Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol

Author

Setiabudi, Wega, primary, Hungerford, Daniel, additional, Subramaniam, Krishanthi, additional, Vaselli, Natasha Marcella, additional, Shaw, Victoria E, additional, Wilton, Moon, additional, Vivancos, Roberto, additional, Aston, Stephen, additional, Platt, Gareth, additional, Moitt, Tracy, additional, Jones, Ashley P, additional, Gabbay, Mark, additional, Buchan, Iain, additional, Carrol, Enitan D, additional, Iturriza-Gomara, Miren, additional, Solomon, Tom, additional, Greenhalf, William, additional, Naisbitt, Dean J, additional, Adams, Emily R, additional, Cunliffe, Nigel A, additional, Turtle, Lance, additional, and French, Neil, additional

Published
2021
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72. A NOVEL AIR-DRIED MULTIPLEX HIGH RESOLUTION MELT ASSAY FOR THE DETECTION OF EXTENDED SPECTRUM BETA-LACTAMASE AND CARBAPENEMASE GENES

Author

Cubas-Atienzar, Ana I., primary, Williams, Christopher T., additional, Karkey, Abhilasha, additional, Dongol, Sabina, additional, Sulochana, Manandhar, additional, Rajendra, Shrestha, additional, Hobbs, Glyn, additional, Evans, Katie, additional, Musicha, Patrick, additional, Feasey, Nicholas, additional, Cuevas, Luis E., additional, Adams, Emily R., additional, and Edwards, Thomas, additional

Published
2021
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73. SARS-CoV-2 Transmission Risk from sports Equipment (STRIKE)

Author

Edwards, Thomas, primary, Kay, Grant A, additional, Aljayyoussi, Ghaith, additional, Owen, Sophie I, additional, Harland, Andy R, additional, Pierce, Nicholas S, additional, Calder, James D F, additional, Fletcher, Tom E, additional, and Adams, Emily R, additional

Published
2021
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75. Investigation of SARS-CoV-2 Faecal Shedding in the Community: A Prospective Household Cohort Study (COVID-LIV) in the UK

Author

Vaselli, Natasha Marcella, primary, Setiabudi, Wega, additional, Subramaniam, Krishanthi, additional, Adams, Emily R., additional, Turtle, Lance, additional, Iturriza-Gómara, Miren, additional, Solomon, Tom, additional, Cunliffe, Nigel A., additional, French, Neil, additional, Hungerford, Daniel, additional, and Group, COVID-LIV Study, additional

Published
2021
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76. IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Author

Staines, Henry M., primary, Kirwan, Daniela E., additional, Clark, David J., additional, Adams, Emily R., additional, Augustin, Yolanda, additional, Byrne, Rachel L., additional, Cocozza, Michael, additional, Cubas-Atienzar, Ana I., additional, Cuevas, Luis E., additional, Cusinato, Martina, additional, Davies, Benedict M.O., additional, Davis, Mark, additional, Davis, Paul, additional, Duvoix, Annelyse, additional, Eckersley, Nicholas M., additional, Forton, Daniel, additional, Fraser, Alice J., additional, Garrod, Gala, additional, Hadcocks, Linda, additional, Hu, Qinxue, additional, Johnson, Michael, additional, Kay, Grant A., additional, Klekotko, Kesja, additional, Lewis, Zawditu, additional, Macallan, Derek C., additional, Mensah-Kane, Josephine, additional, Menzies, Stefanie, additional, Monahan, Irene, additional, Moore, Catherine M., additional, Nebe-von-Caron, Gerhard, additional, Owen, Sophie I., additional, Sainter, Chris, additional, Sall, Amadou A., additional, Schouten, James, additional, Williams, Christopher T., additional, Wilkins, John, additional, Woolston, Kevin, additional, Fitchett, Joseph R.A., additional, Krishna, Sanjeev, additional, and Planche, Tim, additional

Published
2021
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77. Longitudinal Profile of Antibody Response to SARS-CoV-2 in Patients with COVID-19 in a Setting from Sub–Saharan Africa: A Prospective Longitudinal Study

Author

Gebrecherkos, Teklay, primary, Kebede, Yazezew, additional, Challa, Feyissa, additional, Abdella, Saro, additional, Gebreegzabher, Atsbeha, additional, Desta, Abraham, additional, Atsbaha, Ataklti Hailu, additional, Tasew, Geremew, additional, Abdulkader, Mahmud, additional, Tesema, Masresha, additional, Tollera, Getachew, additional, Arefaine, Zekarias Gessesse, additional, Schallig, Henk H.D.F., additional, Adams, Emily R., additional, Urban, Britta C., additional, Rinke De Wit, Tobias F., additional, and Wolday, Dawit, additional

Published
2021
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79. High SARS-CoV-2 seroprevalence in health care workers but relatively low numbers of deaths in urban Malawi

Author

Chibwana, Marah G., primary, Jere, Khuzwayo C., additional, Kamng'ona, Raphael, additional, Mandolo, Jonathan, additional, Katunga-Phiri, Vincent, additional, Tembo, Dumizulu, additional, Mitole, Ndaona, additional, Musasa, Samantha, additional, Sichone, Simon, additional, Lakudzala, Agness, additional, Sibale, Lusako, additional, Matambo, Prisca, additional, Kadwala, Innocent, additional, Byrne, Rachel L., additional, Mbewe, Alice, additional, Henrion, Marc Y. R., additional, Morton, Ben, additional, Phiri, Chimota, additional, Mallewa, Jane, additional, Mwandumba, Henry C., additional, Adams, Emily R., additional, Gordon, Stephen B., additional, and Jambo, Kondwani C., additional

Published
2020
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81. Predicted Impact of COVID-19 on Neglected Tropical Disease Programs and the Opportunity for Innovation

Author

Toor, Jaspreet, primary, Adams, Emily R, additional, Aliee, Maryam, additional, Amoah, Benjamin, additional, Anderson, Roy M, additional, Ayabina, Diepreye, additional, Bailey, Robin, additional, Basáñez, Maria-Gloria, additional, Blok, David J, additional, Blumberg, Seth, additional, Borlase, Anna, additional, Rivera, Rocio Caja, additional, Castaño, María Soledad, additional, Chitnis, Nakul, additional, Coffeng, Luc E, additional, Crump, Ronald E, additional, Das, Aatreyee, additional, Davis, Christopher N, additional, Davis, Emma L, additional, Deiner, Michael S, additional, Diggle, Peter J, additional, Fronterre, Claudio, additional, Giardina, Federica, additional, Giorgi, Emanuele, additional, Graham, Matthew, additional, Hamley, Jonathan I D, additional, Huang, Ching-I, additional, Kura, Klodeta, additional, Lietman, Thomas M, additional, Lucas, Tim C D, additional, Malizia, Veronica, additional, Medley, Graham F, additional, Meeyai, Aronrag, additional, Michael, Edwin, additional, Porco, Travis C, additional, Prada, Joaquin M, additional, Rock, Kat S, additional, Le Rutte, Epke A, additional, Smith, Morgan E, additional, Spencer, Simon E F, additional, Stolk, Wilma A, additional, Touloupou, Panayiota, additional, Vasconcelos, Andreia, additional, Vegvari, Carolin, additional, de Vlas, Sake J, additional, Walker, Martin, additional, and Hollingsworth, T Déirdre, additional

Published
2020
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82. Self-sampling of capillary blood for serological testing of SARS-CoV-2 by COVID-19 IgG ELISA

Author

Brown, Lottie, primary, Byrne, Rachel L, additional, Fraser, Alice, additional, Owen, Sophie I, additional, Cubas-Atienzar, Ana I, additional, Williams, Chris, additional, Kay, Grant A, additional, Cuevas, Luis E, additional, Fitchett, Joseph R A, additional, Fletcher, Tom, additional, Garrod, Gala, additional, Kontogianni, Konstantina, additional, Krishna, Sanjeev, additional, Menzies, Stefanie, additional, Planche, Tim, additional, Sainter, Chris, additional, Staines, Henry M, additional, Turtle, Lance, additional, and Adams, Emily R, additional

Published
2020
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84. Piperacillin/tazobactam resistant, cephalosporin susceptible Escherichia coli bloodstream infections driven by multiple resistance mechanisms across diverse sequence types

Author

Edwards, Thomas, primary, Heinz, Eva, additional, van Aartsen, Jon, additional, Howard, Alex, additional, Roberts, Paul, additional, Corless, Caroline, additional, Fraser, Alice J., additional, Williams, Christopher T., additional, Bulgasim, Issra, additional, Cuevas, Luis E., additional, Parry, Christopher M., additional, Roberts, Adam P., additional, Adams, Emily R., additional, Mason, Jenifer, additional, and Hubbard, Alasdair T. M., additional

Published
2020
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85. Epidemiology of dengue fever in Guatemala

Author

Castillo Signor, Leticia del Carmen, primary, Edwards, Thomas, additional, Escobar, Luis E., additional, Mencos, Yolanda, additional, Matope, Agnes, additional, Castaneda-Guzman, Mariana, additional, Adams, Emily R., additional, and Cuevas, Luis E., additional

Published
2020
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86. Saliva offers a sensitive, specific and non-invasive alternative to upper respiratory swabs for SARS-CoV-2 diagnosis

Author

Byrne, Rachel L, primary, Kay, Grant A, additional, Kontogianni, Konstantina, additional, Brown, Lottie, additional, Collins, Andrea M, additional, Cuevas, Luis E., additional, Ferreira, Daniela M, additional, Fraser, Alice J, additional, Garrod, Gala, additional, Hill, Helen, additional, Menzies, Stefanie, additional, Mitsi, Elena, additional, Owen, Sophie I, additional, Williams, Christopher T, additional, Hyder-Wright, Angela, additional, Adams, Emily R, additional, and Cubas-Atienzar, Ana I, additional

Published
2020
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87. Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections

Author

Staines, Henry M, primary, Kirwan, Daniela E, additional, Clark, David J, additional, Adams, Emily R, additional, Augustin, Yolanda, additional, Byrne, Rachel L, additional, Cocozza, Michael, additional, Cubas-Atienzar, Ana I, additional, Cuevas, Luis E., additional, Cusinato, Martina, additional, Davies, Benedict M O, additional, Davis, Mark, additional, Davis, Paul, additional, Duvoix, Annelyse, additional, Eckersley, Nicholas M, additional, Forton, Daniel, additional, Fraser, Alice J, additional, Garrod, Gala, additional, Hadcocks, Linda, additional, Hu, Qinxue, additional, Johnson, Michael, additional, Kay, Grant A, additional, Klekotko, Kesja, additional, Lewis, Zawditu, additional, Macallan, Derek C, additional, Mensah-Kane, Josephine, additional, Menzies, Stefanie, additional, Monahan, Irene, additional, Moore, Catherine M, additional, Nebe-von-Caron, Gerhard, additional, Owen, Sophie I, additional, Sainter, Chris, additional, Sall, Amadou A, additional, Schouten, James, additional, Williams, Chris, additional, Wilkins, John, additional, Woolston, Kevin, additional, Fitchett, Joseph R A, additional, Krishna, Sanjeev, additional, and Planche, Tim, additional

Published
2020
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89. Rapid development of COVID-19 rapid diagnostics for low resource settings: accelerating delivery through transparency, responsiveness, and open collaboration

Author

Adams, Emily R, primary, Augustin, Yolanda, additional, Byrne, Rachel L, additional, Clark, David J, additional, Cocozza, Michael, additional, Cubas-Atienzar, Ana I, additional, Cuevas, Luis E., additional, Cusinato, Martina, additional, Davies, Benedict M O, additional, Davis, Mark, additional, Davis, Paul, additional, Duvoix, Annelyse, additional, Eckersley, Nicholas M, additional, Edwards, Thomas, additional, Fletcher, Tom, additional, Fraser, Alice J, additional, Garrod, Gala, additional, Hadcocks, Linda, additional, Hu, Qinxue, additional, Johnson, Michael, additional, Kay, Grant A, additional, Keymer, Katherine, additional, Kirwan, Daniela, additional, Klekotko, Kesja, additional, Lewis, Zawditu, additional, Mason, Jenifer, additional, Mensah-Kane, Josie, additional, Menzies, Stefanie, additional, Monahan, Irene, additional, Moore, Catherine M, additional, Nebe-von-Caron, Gerhard, additional, Owen, Sophie I, additional, Planche, Tim, additional, Sainter, Chris, additional, Schouten, James, additional, Staines, Henry M, additional, Turtle, Lance, additional, Williams, Chris, additional, Wilkins, John, additional, Woolston, Kevin, additional, Sall, Amadou Alpha, additional, Fitchett, Joseph R A, additional, and Krishna, Sanjeev, additional

Published
2020
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90. Assessing expanded community wide treatment for schistosomiasis: Baseline infection status and self-reported risk factors in three communities from the Greater Accra region, Ghana

Author

Cunningham, Lucas J., primary, Campbell, Suzy J., additional, Armoo, Samuel, additional, Koukounari, Artemis, additional, Watson, Victoria, additional, Selormey, Pamela, additional, Stothard, J. Russell, additional, Idun, Bright, additional, Asiedu, Manfred, additional, Ashong, Yvonne, additional, Adams, Emily R., additional, and Osei-Atweneboana, Mike Yaw, additional

Published
2020
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92. Within-patient evolution to piperacillin/tazobactam resistance in a clinical isolate ofEscherichia colidue to IS26-mediated amplification ofblaTEM-1B

Author

Hubbard, Alasdair T. M., primary, Mason, Jenifer, additional, Roberts, Paul, additional, Parry, Christopher M., additional, Corless, Caroline, additional, van Aartsen, Jon, additional, Howard, Alex, additional, Fraser, Alice J., additional, Adams, Emily R., additional, Roberts, Adam P., additional, and Edwards, Thomas, additional

Published
2020
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93. Evaluation of Novel Diagnostic Tools for Direct Detection of Leishmania donovani Markers in Clinical Samples to Sustain Visceral Leishmaniasis Elimination in Bangladesh

Author

Hossain, Faria, primary, Picado, Albert, additional, Owen, Sophie, additional, Ghosh, Prakash, additional, Chowdhury, Rajashree, additional, Maruf, Shomik, additional, Khan, Md. Anik Ashfaq, additional, Nath, Rupen, additional, Baker, James, additional, Rashid, Md. Utba, additional, Ghosh, Debashis, additional, Nath, Proggananda, additional, Basher, Ariful, additional, Aktar, Fatima, additional, Hossain, Md. Sakhawat, additional, Duthie, Malcolm S., additional, Adams, Emily R., additional, Cruz, Isra, additional, and Mondal, Dinesh, additional

Published
2020
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97. Investigation of SARS-CoV-2 faecal shedding in the community: a prospective household cohort study (COVID-LIV) in the UK.

Author

Vaselli, Natasha Marcella, Setiabudi, Wega, Subramaniam, Krishanthi, Adams, Emily R., Turtle, Lance, Iturriza-Gómara, Miren, Solomon, Tom, Cunliffe, Nigel A., French, Neil, Hungerford, Daniel, on behalf of the COVID-LIV Study Group, Vivancos, Roberto, Gabbay, Mark, Buchan, Iain, Carrol, Enitan D., Gamble, Carrol, Crossley, Lynnette, Joseph, Neil, Wilton, Moon, and Troughton, Lee D.

Subjects
SARS-CoV-2, COVID-19, INFECTIOUS disease transmission, COHORT analysis, HOUSEHOLDS
Abstract

Background: SARS-CoV-2 is frequently shed in the stool of patients hospitalised with COVID-19. The extent of faecal shedding of SARS-CoV-2 among individuals in the community, and its potential to contribute to spread of disease, is unknown.Methods: In this prospective, observational cohort study among households in Liverpool, UK, participants underwent weekly nasal/throat swabbing to detect SARS-CoV-2 virus, over a 12-week period from enrolment starting July 2020. Participants that tested positive for SARS-CoV-2 were asked to provide a stool sample three and 14 days later. In addition, in October and November 2020, during a period of high community transmission, stool sampling was undertaken to determine the prevalence of SARS-CoV-2 faecal shedding among all study participants. SARS-CoV-2 RNA was detected using Real-Time PCR.Results: A total of 434 participants from 176 households were enrolled. Eighteen participants (4.2%: 95% confidence interval [CI] 2.5-6.5%) tested positive for SARS-CoV-2 virus on nasal/throat swabs and of these, 3/17 (18%: 95% CI 4-43%) had SARS-CoV-2 detected in stool. Two of three participants demonstrated ongoing faecal shedding of SARS-CoV-2, without gastrointestinal symptoms, after testing negative for SARS-CoV-2 in respiratory samples. Among 165/434 participants without SARS-CoV-2 infection and who took part in the prevalence study, none had SARS-CoV-2 in stool. There was no demonstrable household transmission of SARS-CoV-2 among households containing a participant with faecal shedding.Conclusions: Faecal shedding of SARS-CoV-2 occurred among community participants with confirmed SARS-CoV-2 infection. However, during a period of high community transmission, faecal shedding of SARS-CoV-2 was not detected among participants without SARS-CoV-2 infection. It is unlikely that the faecal-oral route plays a significant role in household and community transmission of SARS-CoV-2. [ABSTRACT FROM AUTHOR]

Published
2021
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98. Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates

Author

Bailey, Freddie, primary, Mondragon-Shem, Karina, additional, Haines, Lee Rafuse, additional, Olabi, Amina, additional, Alorfi, Ahmed, additional, Ruiz-Postigo, José Antonio, additional, Alvar, Jorge, additional, Hotez, Peter, additional, Adams, Emily R., additional, Vélez, Iván D., additional, Al-Salem, Waleed, additional, Eaton, Julian, additional, Acosta-Serrano, Álvaro, additional, and Molyneux, David H., additional

Published
2019
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