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281 results on '"Ahmadzadeh, Arman"'

57. Lupus Anticoagulant Is Associated with Critical Cases and High Mortality in COVID-19: A Literature Review.

Author

Moafi, Maral, Ebrahimi, Mohammad Javad, Hatami, Firouze, Gharehbagh, Farid Javandoust, Ahmadzadeh, Arman, Emam, Mohammad Mehdi, Rajaei, Alireza, Mansouri, Davood, and Darazam, Ilad Alavi

Subjects
COVID-19, COVID-19 pandemic, OLDER women, COMPUTED tomography
Abstract

Background: In severe COVID-19 cases, a hypercoagulable state may occur. Antiphospholipid syndrome-related auto-antibodies (APSRAs) contribute to coagulopathy, but their role in COVID-19 remains unclear. We aimed to investigate the prevalence of positive APSRAs and their effect on clinical outcomes in confirmed COVID-19 patients. Materials and Methods: In this cross-sectional study, severe hospitalized COVID-19 cases were enrolled. Demographic and clinical data were obtained from the day of admission. APSRAs including IgG and/or IgM anticardiolipin (aCL) and anti-ß2-glycoprotein1 (anti-ß2GP1) as well as lupus anticoagulant (LAC) were measured. Results: In this study, 54 severe COVID-19 cases with positive RT-PCR and chest CT scans were recruited. Positive APSRAs were found in 7 (12.9%) patients. Positive LAC was a more prevalent marker as compared to other tests (11.1%). The prevalence of positive aCL (IgM or IgG) and anti-ß2 GPI (IgM or IgG) w as 1.8% (in an elderly woman). Lower oxygen saturation was found in the positive APSRAs group as opposed to the negative APSRAs group (70.3±9 vs. 84.8±9.7%). The mortality rate in the positive APSRAs group was significantly higher relative to the negative APSRAs group (83.3% vs. 27.1%; Pvalue: 0.01). Likewise, the mechanical ventilation requirement in the positive group was also higher (50% vs. 27.1%, P-value: 0.28). Conclusion: This study indicated that LAC might be associated with critical cases and high mortality of COVID-19. Nonetheless, the mortality was not related to macrothrombotic incidence. [ABSTRACT FROM AUTHOR]

Published
2023

58. Comparison of bone mineral density in forearm and hip regions and evaluation of area of these 2 sites.

Author

Rajaei, Alireza, Abbasi, Zahra, Emam, Mohammad, Ahmadzadeh, Arman, Farsad, Faraneh, and Sadraee, Haleh

Subjects
BONE density, BONE densitometry, SURFACE area measurement, FOREARM, FEMUR neck, MIDDLE-aged persons
Abstract

Introduction: Osteoporosis is a common disease among middle-aged and older people. Because bone mineral density (BMD) is obtained by dividing bone mineral content by area, accurate measurement of the surface of the studied area plays an important role. Therefore, the purpose of this study was to investigate the area of the hip and forearm regions based on gender and height. Methods: In a cross-sectional descriptive study of 758 individuals (702 female and 56 male, divided into 2 groups of ≥50 years old and <50 years old), experienced personnel performed densitometry of the forearm and femur using a Hologic device. The results were statistically analyzed using SPSS software version 21. Results: In women ≥50 years old who were of white race, one-third of the forearm BMD showed moderate agreement with the femoral neck BMD, and in this group, total forearm BMD showed moderate agreement with the femoral neck BMD. In women <50 years old of Caucasian race, one-third of the forearm BMD showed good agreement with the femoral trochanter. In the same group of individuals, total forearm BMD also showed very good agreement with the femoral trochanter. In women <50 years old of white race, one-third of the forearm BMD showed good agreement with all 4 regions in the femur (trochanter, intertrochanteric, neck, total), and in the same group of individuals, total forearm BMD showed very good agreement with all 4 regions of the femur. Conclusion: According to the results obtained for comparison of forearm one-third with hip areas, it seems that simultaneous measurement of the forearm one-third area and different hip areas increases the accuracy of total BMD measurement. [ABSTRACT FROM AUTHOR]

Published
2022
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71. Frequency and outcome of olfactory impairment and sinonasal involvement in hospitalized patients with COVID-19

Author

Jalessi, Maryam, primary, Barati, Mitra, additional, Rohani, Mohammad, additional, Amini, Elahe, additional, Ourang, Anis, additional, Azad, Zahra, additional, Hosseinzadeh, Farideh, additional, Cavallieri, Francesco, additional, Ghadirpour, Reza, additional, Valzania, Franco, additional, Iaccarino, Corrado, additional, Ahmadzadeh, Arman, additional, and Farhadi, Mohammad, additional

Published
2020
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75. CASE REPORT: Dermatomyositis-lupus overlap syndrome complicated with cardiomyopathy after SARS-CoV-2 infection: A new potential trigger for musculoskeletal autoimmune disease development.

Author

Dadras, Mohammad Shahidi, Rakhshan, Azadeh, Ahmadzadeh, Arman, Hosseini, Seyed Ali, Diab, Reem, Giv, Toktam Safari, and Abdollahimajd, Fahimeh

Subjects
MUSCULOSKELETAL system diseases, SARS-CoV-2, AUTOIMMUNE diseases, COVID-19, SYNDROMES, INFECTION
Abstract

COVID-19 should be considered as a new triggering factor for autoimmune disorders like DM-lupus overlap syndrome. We recommend that patients presenting with dermatomyositis during this pandemic be screened for COVID-19. [ABSTRACT FROM AUTHOR]

Published
2021
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86. Does Regular Use of a Complementary Medicine of Olea Europe and Ficus carica Have Adverse Effects on Lipid Profile and Fasting Blood Glucose of Rheumatoid Arthritis (RA) Patients Under Treatment with DMARD Regimens Containing Methotrexate?

Author

Bahadori, Shahnaz, Ahmadzadeh, Arman, Shams Ardekani, Mohammad Reza, Kamalinejad, Mohammad, Keshavarz, Mansoor, and Salamzadeh, Jamshid

Subjects
Lipid profile, Fasting blood sugar, Olive, Original Article, Rheumatoid arthritis, Fig
Abstract

Rheumatoid arthritis (RA) patients are vulnerable to cardiovascular morbidity and mortality in which atherosclerosis plays a major role. In this study, the lipid profile and fasting blood sugar (FBS) of RA patients receiving a complementary medicine of olive and fig, as add-on therapy for routine disease-modifying antirheumatic drugs (DMARDs) regimen containing low dose methotrexate (MTX), were studied. A randomized controlled clinical trial was designed. Adult RA patients were randomly allocated in two groups receiving routine DMARDs regimen (control group) and routine DMARDs regimen plus the herbal supplementary formulation of olive oil, fig and olive fruits (intervention group). Patients were followed every 4 weeks for total study period of 16 weeks. In addition to demographic and medical history of the patients, the total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), the atherogenic index of plasma (AIP) defined as log(TG/HDL-C), and the fasting blood sugar (FBS) were determined and recorded. 56 patients (control = 27 and intervention = 29), with mean ± sd age of 50.9 ± 12.3 years completed the study. Average MTX dose received by intervention and control groups were 24.30 ± 18.39 and 17.61 ± 15.53 mg/week, respectively (p = 0.11). Repeated measures analysis of variance (ANOVA) revealed that differences between lipid profile indicators and FBS in the two study groups were not statistically significant (P>0.05). No additional substantial adverse reaction was seen in the study groups. Our findings are more reassuring for patients and their doctors to trust on the safety of the investigated complementary preparation to be used as add-on therapy to manage rheumatoid arthritis.

Published
2016

87. Coping with a war on drugs : Bachelor Thesis

Author

Ahmadzadeh, Arman and Rytkönen, Hannes

Subjects
Socialt arbete, Stigma, Social Work, Labeling, Coping, War on drugs
Abstract

After the 2016 election of president Duterte, the Philippines have been actively fighting a war on drugs inside their own country according to the new policies developed by the newly chosen regime. These policies have led to the several thousands of dead in police operations which are by many called out as extrajudicial executions. The purpose of this study is to research the experience of urban people living in a society pervaded by a war on drugs with the goal of contributing to the understanding of how they handle the situation and how it affects their lives. The authors have spent two months in the Philippines, mainly in the Metro Manila area to gather the data for the study through mainly participant observation and semi-structured interviews for an ethnographic study. The results show who are being targeted in the war, how people experience it and create labeling and stigma according to the societal rules and norms as well as how people cope with difficult circumstances out of their control.

Published
2018

88. Biological Optical-to-Chemical Signal Conversion Interface: A Small-Scale Modulator for Molecular Communications

Author

Grebenstein, Laura, primary, Kirchner, Jens, additional, Peixoto, Renata Stavracakis, additional, Zimmermann, Wiebke, additional, Irnstorfer, Florian, additional, Wicke, Wayan, additional, Ahmadzadeh, Arman, additional, Jamali, Vahid, additional, Fischer, Georg, additional, Weigel, Robert, additional, Burkovski, Andreas, additional, and Schober, Robert, additional

Published
2019
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89. Immunopharmacological effect of β‐d‐mannuronic acid (M2000), as a new immunosuppressive drug, on gene expression of miR‐155 and its target molecules (SOCS1, SHIP1) in a clinical trial on rheumatoid arthritis patients.

Author

Mortazavi‐Jahromi, Seyed Shahabeddin, Aslani, Mona, Omidian, Saiedeh, Ahmadzadeh, Arman, Rezaieyazdi, Zahra, and Mirshafiey, Abbas

Subjects
GENE expression, RHEUMATOID arthritis, IMMUNOSUPPRESSIVE agents, CLINICAL trials, MOLECULES, CLINICAL drug trials
Abstract

The positive impacts of β‐d‐mannuronic acid (M2000) on the gene expression of miR‐155, its target molecules (SOCS1 and SHIP1), and NF‐κB transcription factor were demonstrated in a study using the HEK293‐TLR2 cell line. This new drug has been approved as a safe and effective medication by a randomized, multinational, phase III clinical trial on RA patients. The present study aimed to evaluate the oral administration effect of M2000 on the expression levels of the mentioned genes in RA patients. This research was conducted on 12 RA patients and 12 healthy individuals. After extraction of total RNA from PBMCs of patients and synthesis of cDNA, the expression levels of miR‐155, SOCS1, SHIP1, and NF‐κB genes were measured through quantitative Real‐time PCR at baseline and after 12 weeks of M2000 therapy. Our findings showed that the miR‐155 gene expression level significantly decreased in the M2000‐treated patients compared with the baseline (0.76‐fold, with p <.05). The expression levels of SOCS1 and SHIP1 genes significantly increased in the patients treated with M2000 compared with the before treatment (1.46‐, 1.54‐fold, with p <.01, p <.05, respectively). In addition, it was found that the gene expression level of the NF‐κB transcription factor significantly reduced in M2000‐treated patients compared with the baseline (0.81‐fold, with p <.05). This study showed that the oral administration of M2000 was able to reduce the expression of the miR‐155, increase the expression of SOCS1 and SHIP1, and decrease the NF‐κB gene expression (Trial Registration Number: IRCT2017100213739N10). [ABSTRACT FROM AUTHOR]

Published
2020
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93. Biological optical-to-chemical signal conversion interface

Author

Grebenstein, Laura, primary, Kirchner, Jens, additional, Peixoto, Renata Stavracakis, additional, Zimmermann, Wiebke, additional, Wicke, Wayan, additional, Ahmadzadeh, Arman, additional, Jamali, Vahid, additional, Fischer, Georg, additional, Weigel, Robert, additional, Burkovski, Andreas, additional, and Schober, Robert, additional

Published
2018
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