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3,769 results on '"Aledo A"'

54. Programa de Reducción de la Infección Quirúrgica del Observatorio de Infección en Cirugía (PRIQ-O). Documento de priorización y consenso Delphi de recomendaciones para la prevención de la infección de localización quirúrgica

Author

Badia, Josep M, del Toro, M Dolores, Navarro Gracia, Juan F, Balibrea, José M, Herruzo, Rafael, González Sánchez, Carmen, Lozano García, Javier, Rubio Pérez, Inés, Guirao, Xavier, Soria-Aledo, Víctor, and Ortí-Lucas, Rafael

Published
2023
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55. An examination of the efficacy and safety of fenfluramine in adults, children, and adolescents with Dravet syndrome in a real‐world practice setting: A report from the Fenfluramine European Early Access Program

Author

Renzo Guerrini, Nicola Specchio, Ángel Aledo‐Serrano, Milka Pringsheim, Francesca Darra, Thomas Mayer, Antonio Gil‐Nagel, Tilman Polster, Sameer M. Zuberi, Amélie Lothe, Arnold Gammaitoni, and Adam Strzelczyk

Subjects
clinical practice, Dravet syndrome, fenfluramine, refractory epilepsy, seizures, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Objective To examine the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) in three age groups:

Published
2022
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56. Quality of life, socioeconomic and psychological concerns in parents of children with tuberous sclerosis complex, STXBP1 and SYNGAP1 encephalopathies: a mixed method study

Author

María Salcedo-Perez-Juana, Domingo Palacios-Ceña, Ana San-Martín-Gómez, Ángel Aledo-Serrano, and Lidiane Lima Florencio

Subjects
neurodevelopmental disorders, genetic epilepsy, pediatrics, carers, tuberous sclerosis complex, STXBP1, Pediatrics, RJ1-570
Abstract

BackgroundDevelopmental and Epileptic Encephalopathies (DEEs) occur in childhood and are associated with severe epileptic seizures and neurological impairment. The aim of this study was to combine quantitative and qualitative methodologies to comprehensively describe factors related to quality of life, impact on the family and psychosocial factors in parents of children with TSC, STXBP1 and SYNGAP1 variants.MethodsA convergent parallel mixed design including parents of children with DEE. In the cross-sectional study, 20 parents (10STXBP1, five SYNGAP1, five TSC) were given questionnaires on quality of life, impact on the family and psychological factors. In the descriptive qualitative study, in-depth interviews were conducted with 18 parents (nine STXBP1, five TSC, four SYNGAP1) using a semi-structured questionnaire. A thematic analysis was carried out. The results of the two studies were combined by showing similarities and differences through tables, figures, accounts, and joint displays.ResultsIn terms of quality of life, the integrated results were consistent in highlighting the importance of family interaction, although in the qualitative section the influence of the relationship between the children's siblings, the relationship with health professionals and the difficulties in obtaining public aid were highlighted. In terms of impact, the integrated results show that the illness has a significant impact on the family; the financial burden is highlighted, and the experience of the illness is discussed in depth. Finally, the psychological aspects, symptoms such as anxiety, stress and strain, were consistent. Most of the participants reported sleep disturbance, as identified in the questionnaire, although not mentioned in the interviews.ConclusionsThe combined results of the mixed method provide an in-depth analysis of the impact of DEEs on parents of children with STXBP1, SYNGAP1 and TSC.

Published
2023
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57. Inteligencia artificial en epilepsia

Author

Daniel Fouz-Ruiz and Ángel Aledo-Serrano

Subjects
Inteligencia artificial. Epilepsia. Electroencefalograma. Wearables. Crisis epilépticas., Neurology. Diseases of the nervous system, RC346-429
Abstract

La aplicación de la inteligencia artificial se ha expandido en los últimos años en el ámbito de la neurología. Tal como ocurre en otras enfermedades neurológicas, en epilepsia es necesaria la interconexión entre aspectos clínicos, neurofisiológicos y de neuroimagen para tomar decisiones diagnósticas y terapéuticas. Esto conlleva que, para la toma de decisiones de cada paciente, se deba valorar una gran cantidad de información, con la consiguiente demanda de recursos, formación y tiempo por parte del médico. La gran cantidad de información que se genera en la evaluación de un paciente con epilepsia es el escenario perfecto para el desarrollo y aplicación de la inteligencia artificial, alimentando con una infinidad de datos a los sistemas de redes neuronales, además de posibilitar la validación de la metodología en bases de datos multicéntricas. En esta revisión se analizan los modelos de inteligencia artificial con mayores tasas de precisión para la predicción o detección de crisis, algunos de los cuales ya se encuentran en fase de implantación. Asimismo, el auge exponencial de dispositivos portátiles o wearables permite entrever un futuro con mayor autonomía del paciente y un manejo más objetivo y humanizado.

Published
2023
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62. Analysis of the broadcasting and perceived utility through the implementation of a virtual training platform during the pandemic

Author

Sánchez-Santos, Raquel, Morales-Conde, Salvador, Ramos Rodriguez, Jose Luis, Alvarez Peña, Estibaliz, Aranda Narváez, Jose Manuel, Alvarez Gallego, Mario, Badía, Josep María, Balibrea del Castillo, Jose Maria, Garcia-Botella, Alejandra, Guirao Garriga, Xavier, Espin Basany, Eloy, Martin-Antona, Esteban, Martin Perez, Elena, Martinez Cortijo, Sagrario, Pascual Miguelañez, Isabel, Perez Diaz, Lola, Rubio Perez, Ines, and Soria Aledo, Victoriano

Published
2023
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63. Análisis de la difusión y utilidad percibida a través de la implementación de una plataforma de formación virtual durante la pandemia por COVID-19

Author

Sánchez-Santos, Raquel, Morales-Conde, Salvador, Ramos Rodriguez, Jose Luis, Alvarez Peña, Estibaliz, Aranda Narváez, Jose Manuel, Alvarez Gallego, Mario, Badía, Josep María, Balibrea del Castillo, Jose Maria, Garcia-Botella, Alejandra, Guirao Garriga, Xavier, Espin Basany, Eloy, Martin-Antona, Esteban, Martin Perez, Elena, Martinez Cortijo, Sagrario, Pascual Miguelañez, Isabel, Perez Diaz, Lola, Rubio Perez, Ines, and Soria Aledo, Victoriano

Published
2023
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65. Navigating the Landscape for Real-time Localisation and Mapping for Robotics and Virtual and Augmented Reality

Author

Saeedi, Sajad, Bodin, Bruno, Wagstaff, Harry, Nisbet, Andy, Nardi, Luigi, Mawer, John, Melot, Nicolas, Palomar, Oscar, Vespa, Emanuele, Spink, Tom, Gorgovan, Cosmin, Webb, Andrew, Clarkson, James, Tomusk, Erik, Debrunner, Thomas, Kaszyk, Kuba, Gonzalez-de-Aledo, Pablo, Rodchenko, Andrey, Riley, Graham, Kotselidis, Christos, Franke, Björn, O'Boyle, Michael F. P., Davison, Andrew J., Kelly, Paul H. J., Luján, Mikel, and Furber, Steve

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, Computer Science - Robotics
Abstract

Visual understanding of 3D environments in real-time, at low power, is a huge computational challenge. Often referred to as SLAM (Simultaneous Localisation and Mapping), it is central to applications spanning domestic and industrial robotics, autonomous vehicles, virtual and augmented reality. This paper describes the results of a major research effort to assemble the algorithms, architectures, tools, and systems software needed to enable delivery of SLAM, by supporting applications specialists in selecting and configuring the appropriate algorithm and the appropriate hardware, and compilation pathway, to meet their performance, accuracy, and energy consumption goals. The major contributions we present are (1) tools and methodology for systematic quantitative evaluation of SLAM algorithms, (2) automated, machine-learning-guided exploration of the algorithmic and implementation design space with respect to multiple objectives, (3) end-to-end simulation tools to enable optimisation of heterogeneous, accelerated architectures for the specific algorithmic requirements of the various SLAM algorithmic approaches, and (4) tools for delivering, where appropriate, accelerated, adaptive SLAM solutions in a managed, JIT-compiled, adaptive runtime context., Comment: Proceedings of the IEEE 2018

Published
2018
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66. Effect of fenfluramine on seizures and comorbidities in SCN8A‐developmental and epileptic encephalopathy: A case series

Author

Ángel Aledo‐Serrano, Borja Cabal‐Paz, Elena Gardella, Pablo Gómez‐Porro, Otilia Martínez‐Múgica, Alvaro Beltrán‐Corbellini, Rafael Toledano, Irene García‐Morales, and Antonio Gil‐Nagel

Subjects
drug repurposing, epilepsy, genetic epilepsy, seizures, sodium channelopathy, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract SCN8A‐developmental and epileptic encephalopathy is caused by pathogenic variants in the SCN8A gene encoding the Nav1.6 sodium channel, and is characterized by intractable multivariate seizures and developmental regression. Fenfluramine is a repurposed drug with proven antiseizure efficacy in Dravet syndrome and Lennox–Gastaut syndrome. The effect of fenfluramine treatment was assessed in a retrospective series of three patients with intractable SCN8A epilepsy and severe neurodevelopmental comorbidity (n = 2 females; age 2.8–13 years; 8–16 prior failed antiseizure medications [ASM]; treatment duration: 0.75–4.2 years). In the 6 months prior to receiving fenfluramine, patients experienced multiple seizure types, including generalized tonic–clonic, focal and myoclonic seizures, and status epilepticus. Overall seizure reduction was 60%–90% in the last 3, 6, and 12 months of fenfluramine treatment. Clinically meaningful improvement was noted in ≥1 non‐seizure comorbidity per patient after fenfluramine, as assessed by physician‐ratings of ≥“Much Improved” on the Clinical Global Impression of Improvement scale. Improvements included ambulation in a previously non‐ambulant patient and better attention, sleep, and language. One patient showed mild irritability which resolved; no other treatment‐related adverse events were reported. There were no reports of valvular heart disease or pulmonary arterial hypertension. Fenfluramine may be a promising ASM for randomized clinical trials in SCN8A‐related disorders.

Published
2022
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67. Outcomes from a Spanish Expanded Access Program on cannabidiol treatment in pediatric and adult patients with epilepsy

Author

Villanueva, Vicente, García-Ron, Adrián, Smeyers, Patricia, Arias, Eva, Soto, Victor, García-Peñas, Juan José, González-Alguacil, Elena, Sayas, Débora, Serrano-Castro, Pedro, Garces, Mercedes, Hampel, Kevin, Tomás, Miguel, Lara, Julian, de Toledo, María, Barceló, Ines, Aledo-Serrano, Angel, Gil-Nagel, Antonio, Iacampo, Lucas, Falip, Mercè, Saiz-Diaz, Rosa Ana, Gómez-Ibañez, Asier, Sopelana, David, Sanchez-Larsen, Alvaro, and López-González, Francisco Javier

Published
2022
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68. Corrigendum: Intrafamilial variability in SLC6A1-related neurodevelopmental disorders

Author

Benedetta Kassabian, Christina Dühring Fenger, Marjolaine Willems, Angel Aledo-Serrano, Tarja Linnankivi, Pamela Pojomovsky McDonnell, Laina Lusk, Birgit Susanne Jepsen, Michael Bayat, Anja A. Kattentidt-Mouravieva, Anna Abulí Vidal, Gabriel Valero-Lopez, Helena Alarcon-Martinez, Kimberly Goodspeed, Marjon van Slegtenhorst, Tahsin Stefan Barakat, Rikke S. Møller, Katrine M. Johannesen, and Guido Rubboli

Subjects
SLC6A1, intrafamilial variability, epilepsy, neurodevelopmental disorders, intellectual disability, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2023
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69. Prophage identification and molecular analysis in the genomes of Pseudomonas aeruginosa strains isolated from critical care patients

Author

Manuel González de Aledo, Lucia Blasco, Maria Lopez, Concha Ortiz-Cartagena, Inés Bleriot, Olga Pacios, Marta Hernández-García, Rafael Cantón, and Maria Tomas

Subjects
antiviral defense, prophage, CRISPR-Cas, quorum sensing, Pseudomonas aeruginosa, Microbiology, QR1-502
Abstract

ABSTRACT Prophages are bacteriophages integrated into the bacterial host’s chromosome. This research aims to analyze and characterize the existing prophages within a collection of 53 Pseudomonas aeruginosa strains from intensive care units (ICUs) in Portugal and Spain. A total of 113 prophages were localized in the collection, with 18 of them being present in more than one strain simultaneously. After annotation, five of them were discarded as incomplete, and the 13 remaining prophages were characterized. Of 13, 10 belonged to the siphovirus tail morphology group, 2 to the podovirus tail morphology group, and 1 to the myovirus tail morphology group. All prophages had a length ranging from 20,199 to 63,401 bp and a GC% between 56.2% and 63.6%. The number of open reading frames (ORFs) oscillated between 32 and 88, and in 3/13 prophages, more than 50% of the ORFs had an unknown function. With our findings, we show that prophages are present in the majority of the P. aeruginosa strains isolated from Portuguese and Spanish critically ill patients, many of them found in more than one circulating strain at the same time and following a similar clonal distribution pattern. Although a great sum of ORFs had an unknown function, number of proteins in relation to viral defense (anti-CRISPR proteins, toxin/antitoxin modules, proteins against restriction-modification systems) as well as to prophage interference into their host’s quorum sensing system and regulatory cascades were found. This supports the idea that prophages have an influence in bacterial pathogenesis and anti-phage defense. IMPORTANCE Despite being known for decades, prophages remain understudied when compared to the lytic phages employed in phage therapy. This research aims to shed some light into the nature, composition, and role of prophages found within a set of circulating strains of Pseudomas aeruginosa, with special attention to high-risk clones. Given the fact that prophages can effectively influence bacterial pathogenesis, prophage basic research constitutes a topic of growing interest. Furthermore, the abundance of viral defense and regulatory proteins within prophage genomes detected in this study evidences the importance of characterizing the most frequent prophages in circulating clinical strains and in high-risk clones if phage therapy is to be used.

Published
2023
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70. Intrafamilial variability in SLC6A1-related neurodevelopmental disorders

Author

Benedetta Kassabian, Christina Dühring Fenger, Marjolaine Willems, Angel Aledo-Serrano, Tarja Linnankivi, Pamela Pojomovsky McDonnell, Laina Lusk, Birgit Susanne Jepsen, Michael Bayat, Anja A. Kattentidt-Mouravieva, Anna Abulí Vidal, Gabriel Valero-Lopez, Helena Alarcon-Martinez, Kimberly Goodspeed, Marjon van Slegtenhorst, Tahsin Stefan Barakat, Rikke S. Møller, Katrine M. Johannesen, and Guido Rubboli

Subjects
SLC6A1, intrafamilial variability, epilepsy, neurodevelopmental disorders, intellectual disability, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

IntroductionPhenotypic spectrum of SLC6A1-related neurodevelopmental disorders (SLC6A1-NDD) includes intellectual disability (ID), autistic spectrum disorders (ASD), epilepsy, developmental delay, beginning from early infancy or after seizure onset, and other neurological features such as hypotonia and movement disorders. Data on familial phenotypic heterogeneity have been rarely reported, thus in our study we aimed to investigate intrafamilial phenotypic variability in families with SLC6A1 variants.MethodsWe collected clinical, laboratory and genetic data on 39 individuals, including 17 probands, belonging to 13 families harboring inherited variants of SLC6A1. Data were collected through an international network of Epilepsy and Genetic Centers.ResultsMain clinical findings in the whole cohort of 39 subjects were: (a) epilepsy, mainly presenting with generalized seizures, reported in 71% of probands and 36% of siblings or first/second-degree relatives. Within a family, the same epilepsy type (generalized or focal) was observed; (b) ID reported in 100% and in 13% of probands and siblings or first/second-degree relatives, respectively; (c) learning disabilities detected in 28% of the SLC6A1 carriers, all of them were relatives of a proband; (d) around 51% of the whole cohort presented with psychiatric symptoms or behavioral disorders, including 82% of the probands. Out of the 19 patients with psychiatric symptoms, ASD were diagnosed in 40% of them; (e) neurological findings (primarily tremor and speech difficulties) were observed 38.5% of the whole cohort, including 10 probands. Our families harbored 12 different SLC6A1 variants, one was a frameshift, two stop-gain, while the remaining were missense. No genotype–phenotype associations were identified.DiscussionOur study showed that first-or second-degree relatives presented with a less severe phenotype, featuring mainly mild intellectual and/or learning disabilities, at variance with the probands who suffered from moderate to severe ID, generalized, sometimes intractable, epileptic seizures, behavioral and psychiatric disorders. These findings may suggest that a proportion of individuals with mild SLC6A1-NDD might be missed, in particular those with an older age where genetic testing is not performed. Further studies on intrafamilial phenotypic variability are needed to confirm our results and possibly to expand the phenotypic spectrum of these disorders and benefit genetic counseling.

Published
2023
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71. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries

Author

Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, Ghassan Salman, Alam, Mohammed S, Islam, Shahnoor, Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, 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Kassab, Mohamad B, Abou-Abbass, Hussein, Awad, Rabih F, El Assaad, Hadi, Serhan, Fatima Ghazi, Karout, Lina, Chowdhary, Anisa, Itani, Rania, Abu Hamrah, Ali A A, Bellah, Almoataz, Algatanesh, Nassib S, Duwebi, Mousab A, Alkouba, Esraa T, Algehani, Hala M, Alsharif, Monther, Al-maadany, Faraj S, Elkhafeefi, Fatimah S, Buimsaedah, Ahmad M, Ghazal, Sarah M, Amnaina, Mohamed G, Yagoub, Ghozlan Y, yahia, Hana Ramadan bin, Bareig, Elham Hussin, BenHamida, Bahaeddin, Alkimeeshi, Nayrouz, Marwan, Malak, Muhammed, Nawal Aldokali, Benamer, Eman M, Othman, Rema H, Momen, Ahmed A, Ayad, Kusay A, Aldokali, Nawal, Mohammed, Alsnosy Abdullah Khalefa, Sanousi, Enas F, Aboubakr, Saed J, Aboubakr, Islam F, Alttaira, Amal, Benatiga, Sara A, Alteerah, Ilham A, Aldressi, Wafa, Elhwety, Marwa O, Kalifa, Mohamed Fathi, Glessa, Maram A, Abubaker, Taha, Shembesh, Hassan A, Alansari, Arowa, Alkaseek, Akram M, Abusannuga, Malek Mohamed, Alawami, Mohammed A, Elhajdawe, Fras Ammar, Benamwor, Aihab Salem, Aween, 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Daniels, Ian R, Valverde, Joao, Lumley, Edward David John, Walton, Thomas J, Raptis, Dimitri A, Dimitrokallis, Nikolaos, Nathan, Arjun, Motallebzadeh, Reza, Chowdhury, Shihab, Ahmed, Rezwan F A, Mirnezami, Reza, Szakmany, Tamas, Knight, Dominic J, Al-Azzani, Waheeb, Davies, Huw R, Ooi, Setthasorn Zhi Yang, Oo, Khaing K, Cullis, Paul S, Peng, Ed, Demetriades, Andreas K, Tambyraja, Andrew L, Poon, Michael TC, Brennan, Paul M, Oikonomou, Dimitrios, Newman, Samuel E, Le Blevec, Louise, Otify, Mohamed, Szatmary, Peter, Devkaran, Bhavesh, Sochorova, Dana, Sohrabi, Catrin, Sivaprakasam, Rajesh, Goh, Mingzheng Aaron, Atkinson, Kate V, Soares, Delvene, Prce, Daniela, Cann, Johnathon P, Grobbelaar, Amy C, Bradley, Rebecca, Strauss, Helen J, Taha, Ahmed, Minicozzi, Annamaria, Thakur, Bhaskar, Hanoun, Abdullah, Goru, Poornanand, Baumber, Rachel M, Sobti, Anshul S, Cross, George WV, Havenhand, Tom, Antoniou, George A, Chauhan, Govind Singh, Vokshi, Ismail, Mahmud, Ayesha, Albanese, Erminia, Evans, Daisy, Madhuri, Thumuluru Kavitha, Horsnell, Jonathan D, Zalmay, Pardis, Davies, Angharad J, Aljanadi, Firas, Jeganathan, Reubendra, Jones, Mark, Kakos, Christos, vidya, Raghavan, El-Ghobashy, Alaa, Habib, Ahmed M, Reid, Jeremy P, Rajgor, Harshadkumar Dhirajlal, Ahmed, Omar, Branagan, Graham, Mohamedahmed, Ali Yasen Y, Al-Sabbagh, Ali, Chetty, Govind, Kelty, Clive J, EL-Wajeh, Yasin A M, Tomlinson, James E, Rominiyi, Ola, Sinha, Saurabh, Saad, Sanad, Sahu, Banchhita, Charalampakis, Vasileios, Enemosah, Ibrahim, Williams, Simon J, Yaqoob, Hassan N, Laurent, Edward P, Moreau, Joshua L, Frostick, Rhiannon, Parwaiz, Hammad, Aboelmagd, Karim, Pournaras, Dimitri J, Hristova, Kalina H, Iyengar, Karthikeyan P, Mohamed, Muyed, Artioukh, Dmitri Y, Anwar, Sibtain, Hussein, Mostafa K A, Omogbehin, Tomisin S, Herron, Jonathan B T, Labib, Amir, Patel, Preemal, Marsden, Samuel C, Mehdian, Roshana, Santhirakumaran, Gowthanan, Smelt, Jeremy, Agarwal, Ketan, Lancerotto, Luca, Sahnan, Kapil, Shalhoub, Joseph, Donnelly, Liam J, Erridge, Simon, Chidambaram, Swathikan, Luo, Xun, Bansal, Sujesh, Ryan, Neil AJ, Smith, Alexander C D, Flatman, Michael, Wafaie, Imad, Malik, Muhammad Isfandyar Khan, Thumbadoo, Ruben P, Hussain, Shoaib F, Henein, Christin, Hamad, Yousif T, Belgaumkar, Ajay P, Bosanquet, David C, Kolias, Angelos G, Choi, David, Marcus, Hani J, Horsfall, Hugo RM Layard, Khan, Danyal Z, Sahni, Arun, Millward, Christopher P, Render, Luke, Truss, Adam, Elmoslemany, Tarek, Parmar, Chetan, Hanger, Joseph, Sheen, Jonathon, Rait, Jaideep S, Foreman, Jennifer, Marzouqa, Natalie, Fontalis, Andreas, Voulalas, Grigorios, CHEONG, Ryan Chin Taw, Dindyal, Sanjay, Arumugam, Sathyaseelan, Ward, Thomas R W, Stephens, Alastair S, Douka, Eleftheria, Abou-Foul, Ahmad K, McKay, Siobhan C, Kitchen, Mark O, Rees-Stoner, Oliver DJ, Balasubramanya, Supriya, Akhtar, Muhammad Adeel, Warwick, Andrew J, Pawar, Shweta, Dubey, Vivek, Al-Yaseen, Mustafa W, Williams, Christopher YK, Laird, Alexander, Krishna, Kandaswamy, Anyaugo, Ngozi S, Wuraola, Obafemi K, Odejinmi, Funlayo, Craven, Joanna M, West, Charlotte L, Barter, Reece A, Navaratnam, Devaraj M, Malik, Shahbaz S, Mahendran, Vimaladhithan, Zilvetti, Miguel, Lovegrove, Richard E, Board, Tim N, Zeiton, Moez, Sarwar, Safdar A, Duff, Sarah E, Hsabo, Elmuiz A, Nugur, Ashwani Kumar, Morris, Richard M, Lala, Anil K, Kwan-Feinberg, Rita O, Ross, Samuel W, Dressler, Jeremy A, Evans, Faye M, Wason, Shaun E L, Vogel, Keianna R, Wang, Joanna C, Sulciner, Megan L, Hirji, Sameer, Raoof, Mustafa, Wolff, Christopher J, kent, Ilan, Turan, Alparslan, Teixeira, Pedro G, Olson, Kristofor A, Patel, Neil D, Krishnamoorthy, Vijay, Moris, Dimitrios, Rice, Henry E, Gabr, Hesham, Satoskar, Savni R, Castater, Christine A, Jmaileh, Manal, Payne, Rachel E, Kwon, David S, Aarabi, Shahram, Escobar, Pedro F, Kronenfeld, Joshua P, Dalton, Michael K, Etchill, Eric W, Haut, Elliott R, Vervoort, Dominique, Dehal, Ahmed, McKenney, Mark, Elkbuli, Adel, Gosain, Ankush, Abdelsattar, Zaid M, Naunheim, Matthew R, Burks, Ciersten A, Zhou, Allen S, Heng, Marilyn, Abohashem, Shady, Lozano-Calderón, Santiago A, Reisenauer, Janani S, Mouawad, Nicolas J, Diehl, Thomas M, Eriksson, Evert A, Marwaha, Jayson S, Schroeppel, Thomas J, LaRocca, Christopher J, Chang, Grace H, Hassan, Romana, Nosanov, Lauren B, Rickard, Jennifer L, Avraham, Jacob B, Petrone, Patrizio, Sferra, Joseph J, Hadaya, Joseph, Mead, Brittany S, Hauptman, Jason S, Ahmad, Maleeha, Meola, Antonio, Chang, Steven D, Ko, Ara, Specht, Katherine E, Choudhry, Asad, Encalada, Ronald Zerna, Poggio, Juan L, Xing, Hang, Glass, Nina E, Hooker, Robert, Martins, Paulo N, Scott, Erin M, Bankhead, Brittany K, Giorgakis, Emmanouil, Nigh, Joe, Osborn, Tamara, Tay Lasso, Erika L, Beswick, Daniel M, Berndtson, Allison E, Kaups, Krista L, Chen, Lee-lynn, Farrell, Michael S, Boeck, Marissa A, Vaysburg, Dennis M, Kassam, Al-Faraaz, Turner, Kevin M, Dyas, Adam R, Coleman, Julia R, Folsom, Megan, Lam, Christopher M, Kumer, Sean C, Larson, Kelsey, Turner, Scott, Guidry, Christopher, Reddy, Madhuri, Berbel, German, Findley, Austin, Beahm, David, Bur, Andres, Marlor, Derek, Houndschell, Corey, Carver, Shea, Ulrich, Alissa, Bhutiani, Neal, DiChiacchio, Laura, Abdou, Hossam, Napolitano, Lena M, Ghebre, Rahel, Bass, Gary Alan, Kaplan, Lewis J, Martin, Niels D, Duffy, Caoimhe C, Abdelhamid, Sultan S, Daley, Brian J, Roland, Christina L, Dumas, Ryan P, Ban, Vin Shen, Rajesh, Aashish, Davies, Mark G, Purudappa, Prabhudev P, Walters, Camila B, Lin, Nicole, Ruzgar, Nensi M, Ullrich, Sarah J, Trostchansky, Ivan, Bonilla-Cal, Fernando, Castedo, Fabiola, Sobrero, Helena, Acuña, Gastón, Álvarez, Sofía M, Tarigo, Josefina, Carbajal, Ana C, Carbajal, Ana, Reyes, Antonio R, Al-Eryani, Fatima A, Alqousi, Nardeen N, Alattas, Zainab, Al-Saban, Rafat A, Al-Shehari, Mohammed M, ALHammadi, Nawal T, Shream, Sarah A, Al-Naggar, Hamza M, Al-Qalisi, Lina M, Nadeesh, Areej E, Al-Samawi, Hytham H, Bajjah, Hadeel M, AL-Ameri, Saba A, Albably, Jamal F, Ghannam, Rana A, Shamsan, Amatallah H, Meead, Abdullah A, Al- Zubaidi, Riham Q, Zulait, Mohammed A, Najeeb, Halah, Alsayadi, Musaed M, Al-Mashreqi, Seham K, Al-Jomai, Najla A, Alsayadi, Ramzi A, Al-Naggar, Moath M, Almarashi, Hassan A, Musaeed, Hasna M, Al-Raimi, Ibrahim M, Ghanem, Hossam N, Al-Zazay, Karim A, AL-Mahdi, Shehab A, Almontaser, Amatalaleem S, Savopoulos, Vanessa A S, Munthali, James, Kabongo, Kizito M C, Mushiwokufa, Willard, Ngulube, Allan, Ntoto, Crispin, Magama, Praise T, Dzinotyiwei, Daniel, Chivanga, Shelton K, Dube, Ngqabutho S, Sanchez, Ernesto C, Moyo, Assel T, Chengahomwe, Antony, Chinyowa, Simbarashe, Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust

Published
2022
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73. FunAndes – A functional trait database of Andean plants

Author

Selene Báez, Luis Cayuela, Manuel J. Macía, Esteban Álvarez-Dávila, Amira Apaza-Quevedo, Itziar Arnelas, Natalia Baca-Cortes, Guillermo Bañares de Dios, Marijn Bauters, Celina Ben Saadi, Cecilia Blundo, Marian Cabrera, Felipe Castaño, Leslie Cayola, Julia G. de Aledo, Carlos Iván Espinosa, Belén Fadrique, William Farfán-Rios, Alfredo Fuentes, Claudia Garnica-Díaz, Mailyn González, Diego González, Isabell Hensen, Ana Belén Hurtado, Oswaldo Jadán, Denis Lippok, M. Isabel Loza, Carla Maldonado, Lucio Malizia, Laura Matas-Granados, Jonathan A. Myers, Natalia Norden, Imma Oliveras Menor, Kerstin Pierick, Hirma Ramírez-Angulo, Beatriz Salgado-Negret, Matthias Schleuning, Miles Silman, María Elena Solarte-Cruz, J. Sebastián Tello, Hans Verbeeck, Emilio Vilanova, Greta Weithmann, and Jürgen Homeier

Subjects
Science
Abstract

Measurement(s) Bark thickness • Leaf area • Leaf aluminium (Al) content per leaf dry mass • Specific leaf area • Leaf calcium (Ca) content per leaf dry mass • Leaf carbon (C) content per leaf dry mass • Leaf carbon (C) isotope signature (delta 13 C) • Leaf compoundness • Leaf dry mass per leaf fresh mass (leaf dry matter content, LDMC) • Leaf magnesium (Mg) content per leaf dry mass • Leaf nitrogen (N) content per leaf dry mass • Leaf nitrogen (N) isotope signature (delta 15 N) • Leaf phosphorus (P) content per leaf dry mass • Leaf potassium (K) content per leaf dry mass • Leaf texture (sclerophylly, physical strength, toughness) • leaf thickness • Plant growth form • Stem conduit cross-sectional area (vessels and tracheids) • Stem conduit density (vessels and tracheids) • Sapwood specific conductivity Technology Type(s) bark gauge • Scanner Device • inductively-coupled plasma atomic emission spectroscopy • Calculated from area and mass • CN analyzer • Isotope analyzer • in vivo visual assessment • Ratio of fresh to dry mass • punch tester • micrometer • optical analysis of cross sections with specific software • weight and volume measurement • estimated with equations from wood anatomy Factor Type(s) Country • Lat • Long • Elevation • Collection_year Sample Characteristic - Organism Tracheophyta Sample Characteristic - Environment Andean ecosystems • cloud forest • tropical upper montane forest • tropical lower montane forest • Paramo • Andes Sample Characteristic - Location South America • Venezuela • Colombia • Ecuador • Peru • Bolivia • Argentina

Published
2022
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74. Stereoelectroencephalography in the preoperative assessment of patients with refractory focal epilepsy: experience at an epilepsy centre

Author

R. Toledano, R. Martínez-Alvarez, A. Jiménez-Huete, I. García-Morales, Á. Aledo-Serrano, W. Cabrera, G. Rey, P. Campo, J.C. Gómez-Angulo, I. Blumcke, J. Álvarez-Linera, J.M. del Pozo, and A. Gil-Nagel

Subjects
Epilepsia, Cirugía de la epilepsia, Epilepsia farmacorresistente, Estereoelectoencefalografía, Crisis epilépticas, Electrodos profundos, Neurology. Diseases of the nervous system, RC346-429
Abstract

Objective: Stereoelectroencephalography (SEEG) is a technique for preoperative evaluation of patients with difficult-to-localise refractory focal epilepsy (DLRFE), enabling the study of deep cortical structures. The procedure, which is increasingly used in international epilepsy centres, has not been fully developed in Spain. We describe our experience with SEEG in the preoperative evaluation of DLRFE. Material and methods: In the last 8 years, 71 patients with DLRFE were evaluated with SEEG in our epilepsy centre. We prospectively analysed our results in terms of localisation of the epileptogenic zone (EZ), surgical outcomes, and complications associated with the procedure. Results: The median age of the sample was 30 years (range, 4-59 years); 27 patients (38%) were women. Forty-five patients (63.4%) showed no abnormalities on brain MR images. A total of 627 electrodes were implanted (median, 9 electrodes per patient; range, 1-17), and 50% of implantations were multilobar. The EZ was identified in 64 patients (90.1%), and was extratemporal or temporal plus in 66% of the cases. Follow-up was over one year in 55 of the 61 patients undergoing surgery: in the last year of follow-up, 58.2% were seizure-free (Engel Epilepsy Surgery Outcome Scale class I) and 76.4% had good outcomes (Engel I-II). Three patients (4.2%) presented brain haemorrhages. Conclusion: SEEG enables localisation of the EZ in patients in whom this was previously impossible, offering better surgical outcomes than other invasive techniques while having a relatively low rate of complications. Resumen: Objetivo: La estereoelectroencefalografía (E-EEG) es una técnica de evaluación prequirúrgica en pacientes con epilepsia focal refractaria de difícil localización (EFRDL) que permite explorar con electrodos profundos regiones cerebrales de difícil acceso y la profundidad de la corteza. Esta técnica, en auge en centros internacionales, apenas se ha desarrollado en España. Describimos nuestra experiencia con la E-EEG en la evaluación de pacientes con EFRDL. Material y métodos: En los últimos 8 años, 71 pacientes con EFRDL fueron evaluados con E-EEG en nuestro centro. Analizamos prospectivamente los resultados obtenidos en la localización, los resultados quirúrgicos y las complicaciones asociadas a la técnica. Resultados: La mediana de edad fue de 30 años (rango 4-59 años), 27 pacientes eran mujeres (38%). La RM cerebral fue negativa en 45 pacientes (63,4%). Se implantaron 627 electrodos (mediana de 9 electrodos por paciente, rango 1-17), con un 50% de implantaciones multilobares. En 64 (90,1%) pacientes se localizó la zona epileptógena (ZE), siendo extratemporal o temporal plus en el 66% de los casos. En 55 pacientes de los 61 intervenidos el seguimiento fue superior al año: en el último año de seguimiento 32/55 pacientes (58,2%) estaban libres de crisis (Engel I) siendo los resultados favorables (Engel I-II) en el 76,4% de las intervenciones. Tres pacientes (4,2%) presentaron una hemorragia cerebral. Conclusión: La E-EEG permite localizar la ZE en pacientes en quienes anteriormente no era posible, ofreciendo unos resultados quirúrgicos superiores a otras técnicas invasivas y una tasa de complicaciones relativamente baja.

Published
2022
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75. Estereoelectroencefalografía en la evaluación prequirúrgica de epilepsias focales refractarias: experiencia de un centro de epilepsia

Author

R. Toledano, R. Martínez-Álvarez, A. Jiménez-Huete, I. García-Morales, Á. Aledo-Serrano, W. Cabrera, G. Rey, P. Campo, J.C. Gómez-Angulo, I. Blumcke, J. Álvarez-Linera, J.M. del Pozo, and A. Gil-Nagel

Subjects
Epilepsy, Epilepsy surgery, Drug resistant epilepsy, SEEG, Seizures, Depth electrodes, Neurology. Diseases of the nervous system, RC346-429
Abstract

Resumen: Objetivo: La estereoelectroencefalografía (E-EEG) es una técnica de evaluación prequirúrgica en pacientes con epilepsia focal refractaria de difícil localización (EFRDL) que permite explorar con electrodos profundos regiones cerebrales de difícil acceso y la profundidad de la corteza. Esta técnica, en auge en centros internacionales, apenas se ha desarrollado en España. Describimos nuestra experiencia con la E-EEG en la evaluación de pacientes con EFRDL. Material y métodos: En los últimos 8 años, 71 pacientes con EFRDL fueron evaluados con E-EEG en nuestro centro. Analizamos prospectivamente los resultados obtenidos en la localización, los resultados quirúrgicos y las complicaciones asociadas a la técnica. Resultados: La mediana de edad fue de 30 años (rango 4-59 años), 27 pacientes eran mujeres (38%). La RM cerebral fue negativa en 45 pacientes (63,4%). Se implantaron 627 electrodos (mediana de 9 electrodos por paciente, rango 1-17), con un 50% de implantaciones multilobares. En 64 (90,1%) pacientes se localizó la zona epileptógena (ZE), siendo extratemporal o temporal plus en el 66% de los casos. En 55 pacientes de los 61 intervenidos el seguimiento fue superior al año: en el último año de seguimiento 32/55 pacientes (58,2%) estaban libres de crisis (Engel I) siendo los resultados favorables (Engel I-II) en el 76,4% de las intervenciones. Tres pacientes (4,2%) presentaron una hemorragia cerebral. Conclusión: La E-EEG permite localizar la ZE en pacientes en quienes anteriormente no era posible, ofreciendo unos resultados quirúrgicos superiores a otras técnicas invasivas y una tasa de complicaciones relativamente baja. Abstract: Objective: Stereoelectroencephalography (SEEG) is a technique for preoperative evaluation of patients with difficult-to-localise refractory focal epilepsy (DLRFE), enabling the study of deep cortical structures. The procedure, which is increasingly used in international epilepsy centres, has not been fully developed in Spain. We describe our experience with SEEG in the preoperative evaluation of DLRFE. Material and methods: In the last 8 years, 71 patients with DLRFE were evaluated with SEEG in our epilepsy centre. We prospectively analysed our results in terms of localisation of the epileptogenic zone (EZ), surgical outcomes, and complications associated with the procedure. Results: The median age of the sample was 30 years (range, 4-59 years); 27 patients (38%) were women. Forty-five patients (63.4%) showed no abnormalities on brain MR images. A total of 627 electrodes were implanted (median, 9 electrodes per patient; range, 1-17), and 50% of implantations were multilobar. The EZ was identified in 64 patients (90.1%), and was extratemporal or temporal plus in 66% of the cases. Follow-up was over one year in 55 of the 61 patients undergoing surgery: in the last year of follow-up, 58.2% were seizure-free (Engel Epilepsy Surgery Outcome Scale class I) and 76.4% had good outcomes (Engel I-II). Three patients (4.2%) presented brain haemorrhages. Conclusion: SEEG enables localisation of the EZ in patients in whom this was previously impossible, offering better surgical outcomes than other invasive techniques while having a relatively low rate of complications.

Published
2022
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76. Prediction of peritoneal soiling in acute appendicitis with simple clinical and laboratory data. Prospective, multicenter, cohort study of 2,645 adult patients nationwide

Author

Afonso, N., Aguilella, V., Aguiló, J., Alados, J.C., Alberich, M., Apio, A.B., Balongo, R., Bra, E., Bravo-Gutiérrez, A., Briceño, F.J., Cabañas, J., Cánovas, G., Caravaca, I., Carbonell, S., Carrera-Dacosta, E., Castro E, E., Caula, C., Choolani-Bhojwani, E., Codina, A., Corral, S., Cuenca, C., Curbelo, Y., Delgado-Morales, M.M., Delgado-Plasencia, L., Doménech, E., Estévez, A.M., Feria, A.M., Gascón-Domínguez, M.A., Gianchandani, R., González, C., González, M.A., Hevia, R.J., Hidalgo, J.M., Lainez, M., López, F., López-Fernández, J., López-Ruíz, J.A., Lora-Cumplido, P., Madrazo, Z., Marchena, J., Marenco de la Cuadra, B., Martín, S., Martínez Casas, I., Martínez, P., Mena-Mateos, A., Morales-García, D., Mulas, C., Muñoz-Forner, E., Naranjo, A., Navarro-Sánchez, A., Oliver, I., Ortega, I., Ortega-Higueruelo, R., Ortega-Ruiz, S., Osorio, J., Padín, M.H., Pamies, J.J., Paredes, M., Pareja-Ciuró, F., Pérez-Guarinós, C.V., Pérez-Saborido, B., Pintor-Tortolero, J., Plua-Muñiz, K., Rey, M., Rodríguez, I., Ruiz, C., Ruíz, R., Ruiz, S., Sánchez, A., Sánchez, D., Sánchez, R., Sánchez-Cabezudo, F., Sánchez-Santos, R., Santos, J., Serrano-Paz, M.P., Soria-Aledo, V., Taccogna, L., Tallón-Aguilar, L., Valdivia-Risco, J.H., Vallverdú-Cartié, H., Varela, C., Villar-del-Moral, J., Zambudio, N., Lluís, N., Parra, J., Villodre, C., Zapater, P., Jalali, A., Cantó, M., Mena, L., Ramia, J.M., and Lluís, F.

Published
2022
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78. A random mathematical model to describe the antibiotic resistance depending on the antibiotic consumption: the Acinetobacter baumannii colistin-resistant case in Valencia, Spain.

Author

Aledo, Juan A., Andreu-Vilarroig, Carlos, Cortés, Juan-Carlos, Orengo, Juan C., and Villanueva, Rafael-Jacinto

Subjects
*PARTICLE swarm optimization, *PROBABILITY density function, *DRUG resistance in bacteria, *BACTERIAL evolution, *RANDOM variables, *ACINETOBACTER baumannii
Abstract

The increase in antibiotic resistance in recent years, mainly due to the non-rational use of antibiotics, is one of the most important global public health threats. In this paper, we propose a mathematical dynamic random model describing the antibiotic resistance evolution of a bacteria and where antibiotic consumption is included is the main driving force in the resistance increase. The random model is solved using the Random Variable Transformation technique and is applied to study the case of Acinetobacter baumannii bacterium resistant to the antibiotic colistin in Valencia, Spain. Using the Multi-Objective Particle Swarm Optimization algorithm, the model has been calibrated with the A. baumannii colistin-resistance and colistin consumption data series. With the optimal model, four possible 7-year future scenarios with different antibiotic consumption trends have been simulated. The model results show how reducing antibiotic consumption does not easily stop the increase in resistance. [ABSTRACT FROM AUTHOR]

Published
2025
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79. Sleep disturbances in SCN8A‐related disorders.

Author

Furia, Francesca, Johannesen, Katrine M., Bonardi, Claudia M., Previtali, Roberto, Aledo‐Serrano, Angel, Mastrangelo, Massimo, Favaro, Jacopo, Masnada, Silvia, di Micco, Valentina, Proietti, Jacopo, Veggiotti, Pierangelo, Rubboli, Guido, Cantalupo, Gaetano, Olofsson, Kern, Møller, Rikke S., and Gardella, Elena

Subjects
SLEEP duration, SLEEP latency, SODIUM channels, SEIZURES (Medicine), RAPID eye movement sleep, SLEEP, SLEEP interruptions, SLOW wave sleep, NON-REM sleep
Abstract

Copyright of Epilepsia Open is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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80. Newborn Screening for Sickle Cell Disease in Catalonia between 2015 and 2022—Epidemiology and Impact on Clinical Events.

Author

González de Aledo-Castillo, José Manuel, Argudo-Ramírez, Ana, Beneitez-Pastor, David, Collado-Gimbert, Anna, Almazán Castro, Francisco, Roig-Bosch, Sílvia, Andrés-Masó, Anna, Ruiz-Llobet, Anna, Pedrals-Portabella, Georgina, Medina-Santamaria, David, Nadal-Rey, Gemma, Espigares-Salvia, Marina, Coll-Sibina, Maria Teresa, Algar-Serrano, Marcelina, Torrent-Español, Montserrat, Leoz-Allegretti, Pilar, Rodríguez-Pebé, Anabel, García-Bernal, Marta, Solà-Segura, Elisabet, and García-Gallego, Amparo

Published
2024
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81. Perioperative patient safety recommendations: systematic review of clinical practice guidelines.

Author

Martinez-Nicolas, Ismael, Arnal-Velasco, Daniel, Romero-García, Eva, Fabregas, Neus, Otero, Yolanda Sanduende, Leon, Irene, Bartakke, Ashish A, Silva-Garcia, Javier, Rodriguez, Anna, Valli, Claudia, Zamarian, Sandro, Zaludek, Adam, Meneses-Echavez, Jose, Loaiza-Betancur, Andrés F, Sousa, Paulo, Orrego, Carola, Soria-Aledo, Victor, and Consortium, SAFEST

Subjects
PATIENT safety, PERIOPERATIVE care, INFORMATION policy, CONTINUUM of care, DIGITAL libraries
Abstract

Background Surgical-related incidents are a common cause of in-hospital adverse events. Surgical patient safety would benefit from evidence-based practices, but a comprehensive collection of patient safety recommendations is still lacking. This study aimed to compile and assess the perioperative patient safety recommendations for adults. Method A systematic review of clinical practice guidelines was conducted using Medline, Embase, Cochrane, Virtual Health Library Regional Portal, and Trip Database from 2012 to 2022. Eligibility criteria followed a PICAR strategy for patient safety recommendations in the perioperative care continuum. Guidelines were appraised for quality, particularly focusing on the 'rigour of development' domain of the AGREE-II tool for those containing strong recommendations. Descriptive analyses were conducted, emphasizing guideline quality, recommendation strength, and the supporting level of evidence. Results From the 267 guidelines, 4666 perioperative patient safety recommendations were extracted, of which 44.9% (2095) were strongly recommended. Of these, 322 had the highest level of evidence, but only 18 guidelines met high standards in the AGREE-II 'rigour of development' domain. A subset of 78 recommendations ranked the highest in the strength of recommendation, level of evidence, and rigour of development of their guidelines. A gap was found within pre-admission and post-discharge care recommendations. Discussion This review highlights the noteworthy variability in the methodological quality of the guidelines, and a discordance between strength of recommendation and evidence level of the available perioperative patient safety recommendations. These findings provide valuable information for advising policy decisions and promoting best practices to enhance global surgical safety. Registration PROSPERO (CRD42022347449). [ABSTRACT FROM AUTHOR]

Published
2024
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82. Enzyme Kinetic Parameters Estimation: A Tricky Task?

Author

Aledo, Juan C.

Abstract

We are living in the Big Data era, and yet we may have serious troubles when dealing with a handful of kinetic data if we are not properly instructed. The aim of this paper, related to enzyme kinetics, is to illustrate how to determine the K[subscript m] and V[subscript max] of a michaelian enzyme avoiding the pitfalls in which we often fall. To this end, we will resort to kinetic data obtained by second-year Biochemistry students during a laboratory experiment using [beta]-galactosidase as an enzyme model, assayed at different concentrations of its substrate. When these data were analyzed using conventional linear regression of double-reciprocal plots, the range of K[subscript m] and V[subscript max] values obtained by different students varied widely. Even worse, some students obtained negative values for the kinetic parameters. Although such a scenario could make us think of a wide inter-student variability regarding their skills to obtain reliable data, the reality was quite different: when properly analyzed (accounting for error propagation) the data obtained by all the students were good enough to allow a correct estimation of the K[subscript m] (2.8 ± 0.3 mM) and V[subscript max] (179 ± 27 mM/min) with a reduced intergroup standard deviation. A student-accessible discussion of the importance of weighted linear regression in biochemical sciences is provided.

Published
2021
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84. renz: An R package for the analysis of enzyme kinetic data

Author

Juan Carlos Aledo

Subjects
Computer program, Progress curve, Integrated rate equation, Michaelis–Menten, KM, Vmax, Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5
Abstract

Abstract Background Complex enzymatic models are required for analyzing kinetic data derived under conditions that may not satisfy the assumptions associated with Michaelis–Menten kinetics. To analyze these data, several software packages have been developed. However, the complexity introduced by these programs is often dispensable when analyzing data conforming to the canonical Michaelis–Menten model. In these cases, the sophisticated routines of these packages become inefficient and unnecessarily intricated for the intended purpose, reason for which most users resort to general-purpose graphing programs. However, this approach, in addition of being time-consuming, is prone to human error, and can lead to misleading estimates of kinetic parameters, particularly when unweighted regression analyses of transformed kinetic data are performed. Results To fill the existing gap between highly specialized and general-purpose software, we have developed an easy-to-use R package, renz, designed for accurate and efficient estimation of enzyme kinetic parameters. The package provides different methods that can be clustered into four categories, depending on whether they are based on data fitting to a single progress curve (evolution of substrate concentration over time) or, alternatively, based on the dependency of initial rates on substrate concentration (differential rate equation). A second criterion to be considered is whether the experimental data need to be manipulated to obtain linear functions or, alternatively, data are directly fitted using non-linear regression analysis. The current program is a cross-platform, free and open-source software that can be obtained from the CRAN repository. The package is accompanied by five vignettes, which are intended to guide users to choose the appropriate method in each case, as well as providing the basic theoretical foundations of each method. These vignettes use real experimental data to illustrate the use of the package utilities. Conclusions renz is a rigorous and yet easy-to-use software devoted to the analysis of kinetic data. This application has been designed to meet the needs of users who are not practicing enzymologists, but who need to accurately estimate the kinetic parameters of enzymes. The current software saves time and minimizes the risk of making mistakes or introducing biases due to uncorrected error propagation effects.

Published
2022
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85. Phylogenies from unaligned proteomes using sequence environments of amino acid residues

Author

Juan Carlos Aledo

Subjects
Medicine, Science
Abstract

Abstract Alignment-free methods for sequence comparison and phylogeny inference have attracted a great deal of attention in recent years. Several algorithms have been implemented in diverse software packages. Despite the great number of existing methods, most of them are based on word statistics. Although they propose different filtering and weighting strategies and explore different metrics, their performance may be limited by the phylogenetic signal preserved in these words. Herein, we present a different approach based on the species-specific amino acid neighborhood preferences. These differential preferences can be assessed in the context of vector spaces. In this way, a distance-based method to build phylogenies has been developed and implemented into an easy-to-use R package. Tests run on real-world datasets show that this method can reconstruct phylogenetic relationships with high accuracy, and often outperforms other alignment-free approaches. Furthermore, we present evidence that the new method can perform reliably on datasets formed by non-orthologous protein sequences, that is, the method not only does not require the identification of orthologous proteins, but also does not require their presence in the analyzed dataset. These results suggest that the neighborhood preference of amino acids conveys a phylogenetic signal that may be of great utility in phylogenomics.

Published
2022
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86. Simplified risk-prediction for benchmarking and quality improvement in emergency general surgery. Prospective, multicenter, observational cohort study

Author

Afonso, N., Aguilella, V., Aguiló, J., Alados, J.C., Alberich, M., Apio, A.B., Balongo, R., Bra, E., Bravo-Gutiérrez, A., Briceño, F.J., Cabañas, J., Cánovas, G., Caravaca, I., Carbonell, S., Carrera-Dacosta, E., Castro E, E., Caula, C., Choolani-Bhojwani, E., Codina, A., Corral, S., Cuenca, C., Curbelo-Peña, Y., Delgado-Morales, M.M., Delgado-Plasencia, L., Doménech, E., Estévez, A.M., Feria, A.M., Gascón-Domínguez, M.A., Gianchandani, R., González, C., Hevia, R.J., González, M.A., Hidalgo, J.M., Lainez, M., Lluís, N., López, F., López-Fernández, J., López-Ruíz, J.A., Lora-Cumplido, P., Madrazo, Z., Marchena, J., Marenco de la Cuadra, B., Martín, S., Casas, I. Martínez, Martínez, P., Mena-Mateos, A., Morales-García, D., Mulas, C., Muñoz-Forner, E., Naranjo, A., Navarro-Sánchez, A., Oliver, I., Ortega, I., Ortega-Higueruelo, R., Ortega-Ruiz, S., Osorio, J., Padín, M.H., Pamies, J.J., Paredes, M., Pareja-Ciuró, F., Parra, J., Pérez-Guarinós, C.V., Pérez-Saborido, B., Pintor-Tortolero, J., Plua-Muñiz, K., Rey, M., Rodríguez, I., Ruiz, C., Ruíz, R., Ruiz, S., Sánchez, A., Sánchez, D., Sánchez, R., Sánchez-Cabezudo, F., Sánchez-Santos, R., Santos, J., Serrano-Paz, M.P., Soria-Aledo, V., Tallón-Aguilar, L., Valdivia-Risco, J.H., Vallverdú-Cartié, H., Varela, C., Villar-del-Moral, J., Zambudio, N., Villodre, C., Taccogna, L., Zapater, P., Cantó, M., Mena, L., Ramia, J.M., and Lluís, F.

Published
2022
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89. Programmable Systems for Intelligence in Automobiles (PRYSTINE): Final results after Year 3.

Author

Norbert Druml, Anna Ryabokon, Rupert Schorn, Jochen Koszescha, Kaspars Ozols, Aleksandrs Levinskis, Rihards Novickis, Ethiopia Nigussie, Jouni Isoaho, Selim Solmaz, Georg Stettinger, Sergio E. Diaz, Mauricio Marcano, Jorge Villagra, Juan Medina, Martina Schwarz, Antonio Artuñedo, Mauro Comi, Rutger Beekelaar, Onur özçelik, Elif Aksu Tasdelen, Yesim Gürbüz, Jan Saijets, Jukka Kyynäräinen, Dmitry Morits, Björn Debaillie, Maxim Rykunov, Joan Escamilla, Jarno Vanne, Tomi Korhonen, Kalle Holma, Eva-Maria Matzhold, Carlo Novara, Fabio Tango, Paolo Burgio, Giuseppe Calafiore, Milad Karimshoushtari, Emilie Boulay, Miguel Dhaens, Kylian Praet, Han Zwijnenberg, Henri Palm, David Aledo Ortega, Ercan Kalali, Tuomas Pensala, Arto Kyytinen, Morten Larsen, Omar Veledar, Georg Macher, Michael Lafer, Lorenzo Giraudi, Jakob Reckenzaun, Daniel Hammer, Naveen Mohan, Josef Schmid, Alfred Höß, Shai Ophir, Anand Dubey, Jonas Fuchs, Maximilian Lübke, Andrei Anghel, Nicolae-Catalin Ristea, Martin Törngren, Alua Musralina, Marlene Harter, Joseena Memadathil Jose, and George Dimitrakopoulos 0001

Published
2021
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90. New Epidemiological Outcomes in Anthropophilic tinea capitis, a Case Series Study in Northwestern Spain

Author

N. Martínez Campayo, I. Rego Campuzano, M. González de Aledo, M.P. Arévalo Bermúdez, R.M. Fernández Torres, and E. Fonseca

Subjects
Tinea capitis, Dermatosis del cuero cabelludo, Dermatomicosis, Niños, Epidemiología, Dermatology, RL1-803, Internal medicine, RC31-1245
Abstract

Although zoophilic dermatophytes remain the predominant cause of tinea capitis in Spain, an increase due to anthropophilic species has been reported. We report a retrospective observational study that included twenty-four children, who were diagnosed with tinea capitis due to anthropophilic species between 2004 and 2019. 75% of the patients were males with a mean age of 4,88 years. We observed 83,3% of cases from Africa, 4,2% from South America and 12,5% from Spain. Clinically, 70,8% of the patients presented scaly patches and non-scaring alopecia. Trichophyton soudanense was the main dermatophyte of the series (45,8%), followed by Microsporum audouinii (20,8%), Trichophyton tonsurans (12,5%) and Trichophyton violaceum (12,5%). Although this pattern of infection appears to be linked to immigration from Africa, we saw three native cases. The easier transmission of anthropophilic rather than zoophilic dermatophytes could predict a rise in the incidence of tinea capitis and a public health problem. Resumen: Aunque los dermatofitos zoófilos son aparentemente aún la causa principal de tinea capitis en España, se está observando un repunte por especies antropófilas. Presentamos un estudio observacional retrospectivo de veinticuatro niños con tinea capitis antropófila, diagnosticados en nuestro centro entre 2004 y 2019. El 75% de los pacientes fueron varones con una media de edad de 4,88 años. El 83,3% eran africanos, el 4,2% de América del Sur y el 12,5% de España. Clínicamente, en el 70,8% de los casos se observaron parches descamativos con alopecia no cicatricial. Trichophyton soudanense fue el dermatofito más aislado (45,8%), seguido de Microsporum audouinii (20,8%), Trichophyton tonsurans (12,5%) y Trichophyton violaceum (12,5%). Aunque este patrón parece estar relacionado con la inmigración africana, observamos 3 casos nativos. La facilidad de transmisión de los dermatofitos antropófilos permite predecir un aumento en la incidencia de la tinea capitis y un potencial problema de salud pública.

Published
2022
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91. DNA methylation-based classification of malformations of cortical development in the human brain

Author

Jabari, Samir, Kobow, Katja, Pieper, Tom, Hartlieb, Till, Kudernatsch, Manfred, Polster, Tilman, Bien, Christian G., Kalbhenn, Thilo, Simon, Matthias, Hamer, Hajo, Rössler, Karl, Feucht, Martha, Mühlebner, Angelika, Najm, Imad, Peixoto-Santos, José Eduardo, Gil-Nagel, Antonio, Delgado, Rafael Toledano, Aledo-Serrano, Angel, Hou, Yanghao, Coras, Roland, von Deimling, Andreas, and Blümcke, Ingmar

Published
2022
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92. COVID-19 prevalence and mortality in people with epilepsy: A nation-wide multicenter study

Author

Sanchez-Larsen, Alvaro, Conde-Blanco, Estefanía, Viloria-Alebesque, Alejandro, Sánchez-Vizcaíno Buendía, Cristina, Espinosa Oltra, Tatiana, Alvarez-Noval, Amanda, Aledo-Serrano, Angel, Martin-Garcia, Raquel, Ramos-Araque, María E., Campos, Dulce, Valle-Peñacoba, Gonzalo, Sierra-Gómez, Alicia, De Ceballos-Cerrajería, Pablo, Agundez-Sarasola, Marta, Khawaja, Mariam, Hampel, Kevin G., Serra-Martínez, Maria, Arbós-Barber, Clara, Gómez-Ibáñez, Asier, Villino-Boquete, Rafael, Cabezudo-García, Pablo, Rodríguez-Lavado, Ignacio, Principe, Alessandro, and Sopelana-Garay, David

Published
2021
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94. Morphometric and microstructural characteristics of hippocampal subfields in mesial temporal lobe epilepsy and their correlates with mnemonic discrimination

Author

Alicia Comino Garcia-Munoz, Yasser Alemán-Gómez, Rafael Toledano, Claudia Poch, Irene García-Morales, Ángel Aledo-Serrano, Antonio Gil-Nagel, and Pablo Campo

Subjects
hippocampal subfields, microstructural image analysis, mnemonic discrimination, pattern separation, temporal lobe epilepsy (TLE), Neurology. Diseases of the nervous system, RC346-429
Abstract

IntroductionPattern separation (PS) is a fundamental aspect of memory creation that defines the ability to transform similar memory representations into distinct ones, so they do not overlap when storing and retrieving them. Experimental evidence in animal models and the study of other human pathologies have demonstrated the role of the hippocampus in PS, in particular of the dentate gyrus (DG) and CA3. Patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HE) commonly report mnemonic deficits that have been associated with failures in PS. However, the link between these impairments and the integrity of the hippocampal subfields in these patients has not yet been determined. The aim of this work is to explore the association between the ability to perform mnemonic functions and the integrity of hippocampal CA1, CA3, and DG in patients with unilateral MTLE-HE.MethodTo reach this goal we evaluated the memory of patients with an improved object mnemonic similarity test. We then analyzed the hippocampal complex structural and microstructural integrity using diffusion weighted imaging.ResultsOur results indicate that patients with unilateral MTLE-HE present alterations in both volume and microstructural properties at the level of the hippocampal subfields DG, CA1, CA3, and the subiculum, that sometimes depend on the lateralization of their epileptic focus. However, none of the specific changes was found to be directly related to the performance of the patients in a pattern separation task, which might indicate a contribution of various alterations to the mnemonic deficits or the key contribution of other structures to the function.Discussionwe established for the first time the alterations in both the volume and the microstructure at the level of the hippocampal subfields in a group of unilateral MTLE patients. We observed that these changes are greater in the DG and CA1 at the macrostructural level, and in CA3 and CA1 in the microstructural level. None of these changes had a direct relation to the performance of the patients in a pattern separation task, which suggests a contribution of various alterations to the loss of function.

Published
2023
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95. Bundles reduce anastomosis leak in patients undergoing elective colorectal surgery. A propensity score-matched study

Author

M Baeza-Murcia, G Valero-Navarro, E Pellicer-Franco, V Soria-Aledo, M Mengual-Ballester, J. A Garcia-Marin, L Betoret-Benavente, and J. L Aguayo-Albasini

Subjects
bundle, anastomosis leakage, colorectal surgery complicatios, bowel mechanical preparation, inflammatory marker, Surgery, RD1-811
Abstract

Backgroundanastomosis leak still being a handicap in colorectal surgery. Bowel mechanical preparation and oral antibiotics are not a practice recommended in many clinical practice guides. The aim is to analyse the decrease in frequency and severity of postoperative complications, mainly related to anastomotic leak, after the establishment of a bundle.MethodsSingle-center, before-after study. A bundle was implemented to reduce anastomotic leaks and their consequences. The Bundle group were matched to Pre-bundle group by propensity score matching. Mechanical bowel preparation, oral and intravenous antibiotics, inflammatory markers measure and early diagnosis algorithm were included at the bundle.ResultsThe bundle group shown fewer complications, especially in Clavien Dindós Grade IV complications (2.3% vs. 6.2% p 0.05)ConclusionsThe implementation of our bundle in colorectal surgery which include oral antibiotics, mechanical bowel preparation and inflammatory markers, significantly reduces morbidity adjusted to severity of complications, the anastomotic leakage rate, hospital stay and readmissions.Register studyThe study has been registered at clinicaltrials.gov Code: nct04632446.

Published
2023
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98. The different clinical facets of SYN1-related neurodevelopmental disorders

Author

Ilaria Parenti, Elsa Leitão, Alma Kuechler, Laurent Villard, Cyril Goizet, Cécile Courdier, Allan Bayat, Alessandra Rossi, Sophie Julia, Ange-Line Bruel, Frédéric Tran Mau-Them, Sophie Nambot, Daphné Lehalle, Marjolaine Willems, James Lespinasse, Jamal Ghoumid, Roseline Caumes, Thomas Smol, Salima El Chehadeh, Elise Schaefer, Marie-Thérèse Abi-Warde, Boris Keren, Alexandra Afenjar, Anne-Claude Tabet, Jonathan Levy, Anna Maruani, Ángel Aledo-Serrano, Waltraud Garming, Clara Milleret-Pignot, Anna Chassevent, Marije Koopmans, Nienke E. Verbeek, Richard Person, Rebecca Belles, Gary Bellus, Bonnie A. Salbert, Frank J. Kaiser, Laure Mazzola, Philippe Convers, Laurine Perrin, Amélie Piton, Gert Wiegand, Andrea Accogli, Francesco Brancati, Fabio Benfenati, Nicolas Chatron, David Lewis-Smith, Rhys H. Thomas, Federico Zara, Pasquale Striano, Gaetan Lesca, and Christel Depienne

Subjects
SYN1, synapsins, reflex epilepsy, genotype-phenotype correlation, neurodevelopmental disorders, autism spectrum disorders, Biology (General), QH301-705.5
Abstract

Synapsin-I (SYN1) is a presynaptic phosphoprotein crucial for synaptogenesis and synaptic plasticity. Pathogenic SYN1 variants are associated with variable X-linked neurodevelopmental disorders mainly affecting males. In this study, we expand on the clinical and molecular spectrum of the SYN1-related neurodevelopmental disorders by describing 31 novel individuals harboring 22 different SYN1 variants. We analyzed newly identified as well as previously reported individuals in order to define the frequency of key features associated with these disorders. Specifically, behavioral disturbances such as autism spectrum disorder or attention deficit hyperactivity disorder are observed in 91% of the individuals, epilepsy in 82%, intellectual disability in 77%, and developmental delay in 70%. Seizure types mainly include tonic-clonic or focal seizures with impaired awareness. The presence of reflex seizures is one of the most representative clinical manifestations related to SYN1. In more than half of the cases, seizures are triggered by contact with water, but other triggers are also frequently reported, including rubbing with a towel, fever, toothbrushing, fingernail clipping, falling asleep, and watching others showering or bathing. We additionally describe hyperpnea, emotion, lighting, using a stroboscope, digestive troubles, and defecation as possible triggers in individuals with SYN1 variants. The molecular spectrum of SYN1 variants is broad and encompasses truncating variants (frameshift, nonsense, splicing and start-loss variants) as well as non-truncating variants (missense substitutions and in-frame duplications). Genotype-phenotype correlation revealed that epileptic phenotypes are enriched in individuals with truncating variants. Furthermore, we could show for the first time that individuals with early seizures onset tend to present with severe-to-profound intellectual disability, hence highlighting the existence of an association between early seizure onset and more severe impairment of cognitive functions. Altogether, we present a detailed clinical description of the largest series of individuals with SYN1 variants reported so far and provide the first genotype-phenotype correlations for this gene. A timely molecular diagnosis and genetic counseling are cardinal for appropriate patient management and treatment.

Published
2022
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99. Institutional factors associated with adherence to enhanced recovery protocols for colorectal surgery: Secondary analysis of a multicenter study

Author

Garcia-Perez, Cristina, Higuera-Míguelez, Eva, Marcos-Vidal, José M., Merino-García, María, Rubio-López, Ana B., Pascual-Diez, María E., García-Miguel, Francisco J., Cabezudo-Sanjose, Luis R., Martínez-Díaz, Ruth, Alegría-Rebollo, Sara, González-Rodríguez, José L., Vega-Cruz, María S., Martínez-Ragüés, Gema, Gómez-Ríos, Manuel A., Mosquera-Rodríguez, Eva, Del-Río-Regueira, Sara, Bustos-García, Domingo, Sánchez-Conde, María P., Rodríguez-Calvo, Antonio, Hernández-Valero, María A., Angoso-Clavijo, María, González-Fernández, Luis M., Bravo-Riaño, Miguel A., Arnes-Muñoz, María V., Perez-Valdivieso, José R., Martin-Vizcaino, Marta, Hernandez-Garcia, Susana, Yoldi-Murillo, Francisco J., Salvador-Bravo, Miguel, Rubial-Alvarez, Manuela, Oteiza-Martinez, Fabiola, Balen-Rivera, Enrique, Garcia-Erce, José A., Zugasti-Murillo, Ana, Petrina-Jáuregui, María E., Bustos-Molina, Filadelfo, Paz-Martín, Daniel, Vázquez-Vicente, Bárbara, González-López, Lourdes, Mínguez-Marín, Conrado, Diz-Jueguen, Susana, Seoane-Antelo, Jaime, Ballinas-Miranda, Julio, Carrera-Dacosta, Ester, Barreiro-Domínguez, Erica, Piñeiro-Teijeiro, Alexandra, Sanchez-Santos, Raquel, Varela-Duran, Marina, Diaz-Parada, Pilar, Calero-Lillo, Aránzazu, López-Lara, Manuel Ángel, Muñoz-Collado, Salvador, Valverde-Sintas, Juan, Aznar-Puig, Silvia, Troyano-Escribano, Daniel, Marmaña-Mezquita, Sandra, Fernanz-Antón, Jesús, Catot-Alemany, Lucia, Balust, Jaume, Ubré, Marta, Ferrando-Ortolá, Carlos, Martínez-Pallí, Graciela, Ibarzabal, Ainitze, Lacy, Antonio M., Sánchez-Martín, Rubén, Martins-Cruz, Karina, Pérez-Jiménez, Paula, Casans-Francés, Rubén, Longás, Javier, Ramírez Rodríguez, José M., Mugarra-Llopis, Ana, Crisan, Cristina, Gracia-Ferrándiz, Estefanía, Romero-Vargas, Esther, Soro-Domingo, Marina, Rodríguez-Jiménez, Rita, Prada-Martin, Blanca, Muñoz-Hernández, Henar, Gómez Herrera, José I., Cocho-Crespo, Sara, Fernández-Caballero, Sandra, Flores-Crespo, Miguel, Vázquez-Fernández, Andrea, Brugiotti, Carlo, Ollé-Sese, Estefanía, Houghton-Acuña, Carla R., López-Doucil, Marta, Tarazona-López, Ernesto A., BEL-Marcobal, Iván, González-Cogollor, Sonia, Llácer-Pérez, Manuel, Arias-Romano, Alberto, Arrabal-Taborda, María C., Caballero-Domínguez, Mercedes, García-López, Rafael, Ontoria-Muriel, Julio, Vivó-Blasco, Antonio, Blanco, Francisco J., DEL-Cojo-Peces, Enrique, Tena-Guerrero, Jose M., Landaluce-Olavarria, Aitor, Badiola, Izaskun, Calvo, Marta, DE-Andres, Unai, Portugal-Porras, Vicente, Ugarte-Sierra, Bakarne, Pedregosa-Sanz, Ana, Perelló-Cerdà, Laura, Rodríguez-Téllez, Yobanys, Grössl-Meleán, Joanna, Viñas-Truñén, Xavier, Alday-Muñoz, Enrique, Bermejo-Marcos, Elena, Alonso-Casado, Pedro A., Gimeno-Calvo, Francisco A., Rodriguez-Sánchez, Ana, Montes-López, Carmen, Álvarez-Llano, Laura, FAS-Vicent, María J., Ortega-Monzó, Juan M., Flores-Flores, Gustavo, Tristancho, José L., Bayo-Sans, Montserrat, Deiros-Garcia, María C., GIL-Gómez, María L., Parra, Lourdes, Tejedor-DE-LA-Fuente, Vanesa, Jericó-Alba, Carlos, Borrell-Brau, Núria, Camacho-Martín, David, Ortiz-DE-Zarate, Jose L., López-Ruiz, Daniel, Rodriguez-Bustamante, Vicens, Martinez-Vilalta, M., Amoros-Ruiz, Daniel, Sadurni-Sarda, Marc, Matas, Fernando A.L.C.A.L.D.E., Giordano, Hernán, Perez Peña, Jose M., Olmedilla-Arnal, Luis, Benito-SAZ, Pilar, López-GIL, Elena, Ruiz-Ortega, Adela, Zapatero-García, Sara, DEL-Valle-García, Emilio, Soria-Aledo, Víctor, Pérez-Guarinos, Carmen V., Pellicer-Franco, Enrique, Valero-Navarro, Graciela, Mengual-Ballester, Mónica, García-Marín, José Andrés, Romero-Simó, Manuel, Caravaca-García, Ibán, Blasco-Segura, Teresa, Campo-Betancourth, Carlos F., Costa-Navarro, Rafael David, Jordá-Sanz, Laura, DE-Miguel-Cabrera, María I., España-Pamplona, José M., GIL-Trujillo, Silvia, Redondo-Calvo, Francisco J., Baladrón-Gónzalez, Víctor, Moreno-Ballesteros, Remedios, Muñoz-Rodes, José L., Miranda, Elena, Roselló-Chornet, Marta, Alós-Zaragoza, Lourdes, Catalá-Bauset, Juan, Pallardo-López, María A., Almenara-Almenara, Noemí, Muñoz-Devesa, Lorena, Alcaide-Pardo, Benito, Gimeno-Fernández, Pablo, Gómez-Agraz, José L., Iglesias-Morales, Carla, Ordoñez-Enireb, Paola B., Ríos-Villalba, Ana M., Rodríguez-Pinto, Joselvy, Sánchez-Cortés, Sergio, Montoya-Tabares, María J., Ruiz, Vicente, González-Sánchez, Francisco, Soriano-Giménez, Víctor, Muñoz-Camarena, José M., Benavides-Buleje, Jorge, Estupiñán-Jiménez, Juan C., Portero-Larragueta, Irene, Alias, David, Alberola-Estellés, María J., Díaz-Cambronero, Óscar, Matoses-Jaén, María S., Ruiz-Boluda, María D., Maristany-Bienert, Carlos, Pardo-López, José A., Ramiro-Ruiz, Álvaro, García, Pablo, Martínez-DE-Guereñu, Arantza, Montalbán, Belinda, Olea, Claudia, Benguría, David, Silva, Javier, Calderón, Adriana, Escoll-Rufino, Jordi, Cerdan-Santacruz, Carlos, Sierra-Grañón, José E., Rufas-Acín, María, Mestres-Petit, Nuria, Penagos-Saavedra, Ingrid C., Moreno-Castilla, Cristina, Riera-RIU, Jordi, Cuellar-Martínez, Ana, González-Álvarez, R.C., Sánchez-Merchante, Míriam, García-DEL-Valle-Y-Manzano, Santiago, García-Zamorano, Sara, Gijón-Herreros, Natalia, Robles-Ángel, Patricia, Logroño-Ejea, Margarita, Sanllorente-Sebastian, Rodrigo, Villalain-Perez, Maria C., Siclama-Stroe, Mihaela, Benítez-Villar, Judith, Sánchez-Campos, Alberto, Martínez-Ruiz, Alberto, Alonso-Carnicero, Patricia, DE-LA-Torre-González, Francisco J., Naranjo-Checa, Carolina, Pereira-Pérez, Fernando, Ruiz-Ucar, Elena, Rivera, Alfredo, GIL-Lapetra, Cristina, Roca-Castillo, Enrique, Mariscal-Flores, María L., Morales-Cayuela, Mario, Alonso-Ramos, Irene, Jiménez-Carneros, Virginia, Casalduero-Garcia, Lucas, Jimenez-Miramón, Javier, José, L., Nogués-Ramia, Eva M., Sosa-Quesada, Yolanda, Gómez, Alonso, Martínez-Meco-Ortiz, Laura M., Cabellos-Olivares, Mercedes, Rodríguez-Fraile, José R., Labalde-Martínez, María, Ramos-Rodríguez, Nacarino-Alcorta, Beatriz, Fernández-García, Raquel, DE-LA-Quintana-Gordon, Borja, Drewniak, Justyna, Senra-L, Fátima, Galindo-Jara, Pablo, Gallardo-Herrera, Ana B., García-Llorente, Cesar, Colao-García, Laura, Rellan-Álvarez, Luz-Divina, Miro-Murillo, Miguel, Flores-Risco, Sahely-CLARET, Serrat-Puyol, Jordi, Medina-Gallardo, Adrian, Mitsahid-Curbelo-Peña, Yuhami, Orenzana, Abad-Motos, Ane, Abad-Gurumeta, Alfredo, Aracil-Escoda, Norma, Martínez-Hurtado, Eugenio, Nozal-Mateo, Beatriz, Sáez-Ruiz, Elena, Salvachua-Fernández, Rut, Ripollés-Melchor, Javier, DE-Fuenmayor-Valera, María L., Sánchez, Elena, Toribio, Begoña, Navarro-Sánchez, Antonio, López-Fernández, José, Montesdeoca-Cabrera, Dácil, Alcalá-Serrano, Francisco J., Sancho-DE-Avila, Azahara, Diaz-Carrasco, Sofia, Martín-Martín, Almudena, Suarez-DE-LA-Rica, Alejandro, UÑA-Orejón, Rafael, Maseda, Emilio, Tejón-Pérez, Guillermo, Alfaro-Martínez, María V., Alonso-Fernández, Marta, Álvarez-Cebrián, María A., Álvarez-DEL-Vayo-Rodríguez, María J., Carrillo-Rivas, Mariana, Fernández-Rodríguez, María, Trabanco-Morán, Sonia, Rábago-Morán, José L., Martínez-Ubieto, Javier, Pascual-Bellosta, Ana M., Ortega-Lucea, Sonia M., Santero-Ramirez, Maria P., Duque-Mallen, Maria V., Aragon-Benedi, Cristian, Vallejo-Tarrat, Andrea, Colillas-Calvet, Carmen, Laso, Maria J., Martinez-Cabañero, Javier, Hernández-Salván, Javier, Ledesma-Muñoz, Beatriz, Ochoa-Osorio, Carolina, Sanz-García, Máximo, Herrero-Garrote, Begoña, Blázquez-Martin, Alma, Díez-Alonso, Manuel, Hernández-Juara, Pilar, Muguerza-Huguet, José M., Barbero-Mielgo, Macarena, SAN-Antonio-SAN-Román, Belén, Alonso-Aguilar, Laura, Molnar, Viktoria, Delgado-Naviero, María C., Meléndez-Leal, Encarnación, Cavero-García, Virginia, Fernández-Sánchez, África, Cubek-Quevedo, Daniela A., Munar, Rocío D.Í.E.Z., Blázquez-Fernández-DE-LA Pradilla, Francisco J., Serrano, Ana B., Balvís, Alberto, Berruezo, Alberto, Esparza, Elena, HOZ, Inés D.E.L.A., Palavicini, Ana, Pereira, Lucia, Vega, Ximena, Villahoz, Judith, Villanueva, Gema, Alonso-Fernández, José I., Aldecoa, César, Bolaño-Pérez, Clara, Villán-González, Teresa, Batalla, Astrid, Azparren, G., Basttita, M., Felipe, M., Cueva, L., Gine, Marta, Gómez-Caro, A.M., India, I., Piñol, S., Esteve-Pérez, Neus, Mora-Fernández, Carlos, Ferrer-Robles, Ana, Segura-Sampedro, Juan J., Alonso-Hernández, Natalia, Camps-Cervantes, Angels, Chocrón-DA-Prat, Ivette, Coronado-Silva, Carolina C., Duque-Santos, Héctor, Esclapez-Sempere, Elena, Galan-Menéndez, Patricia, Matarín-Olmo, Silvia, Tormos-Pérez, M.P., Villarino-Villa, Laura, Bergés-Gutiérrez, Héctor, Aisa-Gasca, Miguel, Arbona-Camillero, Verónica, Bautista-González, José D., Carballido-Pascual, Francisco J., Gutiérrez-Moreno, Mercedes, Muñoz-Durán, Ana, Cañete-Gómez, Jesús, Cáceres-Fabrega, Esther, Lorente-Herce, José M., Mulet-Zayas, Octavio, Gómez-Pérez, Rocío, Monje-Salazar, Cristina, Lobato-Bancalero, Luis, Torres-Moreno, Carmelo, Sanchez-Cárdenas, Elena, Daza-González, Juan J., Sanchez-Viguera, Teresa, DEL-Fresno-Asensio, Antonio, Bermudez-Román, Laura, Jover-Pinillos, José L., Orts-Micó, Francisco J., Cózar-Lozano, Coral, Blasco-Delgado, Olga, Nonnemacher-SAN-Julián, Andrea, Pérez, José A., Cruces, Laura D.U.R.Á.N., Renedo-Corcóstegui, Pablo, Zorrilla-Vaca, Andres, Stone, Alexander B., Ripolles-Melchor, Javier, Ramirez-Rodriguez, Jose M., Galan-Menendez, Patricia, Mena, Gabriel E., and Grant, Michael C.

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2021
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