Author: "Als, Thomas D." - Searchworks@Jio Institute Digital Library Search Results

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272 results on '"Als, Thomas D."'

51. Single Nucleotide Polymorphisms Associated with Methotrexate-induced Nausea in Juvenile Idiopathic Arthritis

Author: Kyvsgaard, Nini, primary, Mikkelsen, Torben Stamm, additional, Als, Thomas D., additional, Christensen, Anne Estmann, additional, Corydon, Thomas J., additional, and Herlin, Troels, additional
Published: 2021
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52. Genome-wide association study of school grades identifies a genetic overlap between language ability, psychopathology and creativity

Author: Rajagopal, Veera M., Ganna, Andrea, Coleman, Jonathan R. I., Allegrini, Andrea G., Voloudakis, Georgios, Grove, Jakob, Als, Thomas D., Horsdal, Henriette T., Petersen, Liselotte, Appadurai, Vivek, Schork, Andrew, Buil, Alfonso, Bulik, Cynthia M., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Hougaard, David M., Mors, Ole, Nordentoft, Merete, Werge, Thomas, Consortium, iPSYCH-Broad, Mortensen, Preben Bo, Breen, Gerome, Roussos, Panos, Plomin, Robert, Agerbo, Esben, Børglum, Anders D., and Demontis, Ditte
Subjects: 0303 health sciences, education.field_of_study, media_common.quotation_subject, Population, education, Cognition, Genome-wide association study, Creativity, Educational attainment, language.human_language, Danish, 03 medical and health sciences, 0302 clinical medicine, language, Association (psychology), 030217 neurology & neurosurgery, 030304 developmental biology, Clinical psychology, media_common, Psychopathology
Abstract: Individuals with psychiatric disorders perform differently in school compared to the general population. Genetic factors contribute substantially to such differences. It is however unclear if differential performance is seen across all cognitive domains such as math and language. Here we report a genome-wide association study (GWAS) of school grades in 30,982 individuals (18,495 with and 12,487 without one or more of six major psychiatric disorders) and a replication study in 4,547 individuals. GWAS of overall school performance yielded results that were highly similar to the results of a previous GWAS of educational attainment. Analyzing subject specific grades, we observed that math performance was severely affected whereas language performance (Danish and English) was relatively unaffected or enhanced in those with psychiatric disorders compared to controls. We found that the genetic variants associated with poor math performance, but better language performance were also associated with increased risk for multiple psychiatric disorders. The same variants were also associated with creativity, which we show through a polygenic score analysis of 2953 creative professionals and 164,622 controls. The results overall suggest that risk for psychiatric disorders, language ability and creativity might have overlapping genetic roots.
Published: 2020
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53. Genetic analyses identify widespread sex-differential participation bias

Author: Pirastu, Nicola, Cordioli, Mattia, Nandakumar, Priyanka, Mignogna, Gianmarco, Abdellaoui, Abdel, Hollis, Benjamin, Kanai, Masahiro, Rajagopal, Veera M., Della Briotta Parolo, Pietro, Baya, Nikolas, Carey, Caitlin, Karjalainen, Juha, Als, Thomas D., Van der Zee, Matthijs D., Day, Felix R., Ong, Ken K., Study, Finngen, Morisaki, Takayuki, de Geus, Eco, Bellocco, Rino, Okada, Yukinori, Børglum, Anders D., Joshi, Peter, Auton, Adam, Hinds, David, Neale, Benjamin M., Walters, Raymond K., Nivard, Michel G., Perry, John R.B., Ganna, Andrea, and Adult Psychiatry
Subjects: 0303 health sciences, Participation bias, Locus (genetics), Genome-wide association study, Heritability, Biology, 03 medical and health sciences, 0302 clinical medicine, Sample size determination, Allele, 10. No inequality, Body mass index, 030217 neurology & neurosurgery, 030304 developmental biology, Genetic association, Demography
Abstract: Genetic association results are often interpreted with the assumption that study participation does not affect downstream analyses. Understanding the genetic basis of this participation bias is challenging as it requires the genotypes of unseen individuals. However, we demonstrate that it is possible to estimate comparative biases by performing GWAS contrasting one subgroup versus another. For example, we show that sex exhibits autosomal heritability in the presence of sex-differential participation bias. By performing a GWAS of sex in ~3.3 million males and females, we identify over 158 autosomal loci significantly associated with sex and highlight complex traits underpinning differences in study participation between sexes. For example, the body mass index (BMI) increasing allele at the FTO locus was observed at higher frequency in males compared to females (OR 1.02 [1.02-1.03], P=4.4×10−36). Finally, we demonstrate how these biases can potentially lead to incorrect inferences in downstream analyses and propose a conceptual framework for addressing such biases. Our findings highlight a new challenge that genetic studies may face as sample sizes continue to grow.
Published: 2020

54. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

Author: Maretty, Lasse, Jensen, Jacob Malte, Petersen, Bent, Sibbesen, Jonas Andreas, Liu, Siyang, Villesen, Palle, Skov, Laurits, Belling, Kirstine, Theil Have, Christian, Izarzugaza, Jose M. G., Grosjean, Marie, Bork-Jensen, Jette, Grove, Jakob, Als, Thomas D., Huang, Shujia, Chang, Yuqi, Xu, Ruiqi, Ye, Weijian, Rao, Junhua, Guo, Xiaosen, Sun, Jihua, Cao, Hongzhi, Ye, Chen, van Beusekom, Johan, Espeseth, Thomas, Flindt, Esben, Friborg, Rune M., Halager, Anders E., Le Hellard, Stephanie, Hultman, Christina M., Lescai, Francesco, Li, Shengting, Lund, Ole, Lngren, Peter, Mailund, Thomas, Matey-Hernandez, Maria Luisa, Mors, Ole, Pedersen, Christian N. S., Sicheritz-Pontn, Thomas, Sullivan, Patrick, Syed, Ali, Westergaard, David, Yadav, Rachita, Li, Ning, Xu, Xun, Hansen, Torben, Krogh, Anders, Bolund, Lars, Srensen, Thorkild I. A., Pedersen, Oluf, Gupta, Ramneek, Rasmussen, Simon, Besenbacher, Sren, Brglum, Anders D., Wang, Jun, Eiberg, Hans, Kristiansen, Karsten, Brunak, Sren, and Schierup, Mikkel Heide
Subjects: DNA sequencing -- Methods, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract: Author(s): Lasse Maretty [1]; Jacob Malte Jensen [2, 3]; Bent Petersen [4]; Jonas Andreas Sibbesen [1]; Siyang Liu [1, 5]; Palle Villesen [2, 3, 6]; Laurits Skov [2, 3]; Kirstine [...]
Published: 2017
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55. The origin of the isolated population of the Faroe Islands investigated using Y chromosomal markers

Author: Jorgensen, Tove H., Buttenschön, Henriette N., Wang, August G., Als, Thomas D., Børglum, Anders D., and Ewald, Henrik
Published: 2004
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56. The evolution of alternative parasitic life histories in large blue butterflies

Author: Als, Thomas D., Vila, Roger, Kandul, Nikolai P., Nash, David R., Yen, Shen-Horn, Hsu, Yu-Feng, Mignault, Andre A., Boomsma, Jacobus J., and Pierce, Naomi E.
Subjects: Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract: Author(s): Thomas D. Als [1, 2, 7, 8]; Roger Vila [2, 7]; Nikolai P. Kandul [2]; David R. Nash [3]; Shen-Horn Yen [4, 5]; Yu-Feng Hsu [6]; AndrÃ© A. Mignault [...]
Published: 2004
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57. Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression

Author: Koefoed, Pernille, Woldbye, David P.D., Hansen, Thomas v. O., Eplov, Lene F., Christiansen, Sren H., Mors, Ole, Kessing, Lars V., Werge, Thomas, Kaipio, Katja, Pesonen, Ullamari, Fahmy, Thomas, Mellerup, Erling, Jakobsen, Klaus D., Hansen, Elsebeth S., Knudsen, Gitte M., Bukh, Jens D., Bock, Camilla, Lindberg, Camilla, Kristensen, Ann S., Dam, Henrik, Nordentoft, Merete, Als, Thomas D., Wang, August G., Gether, Ulrik, Rehfeld, Jens F., and Bolwig, Tom G.
Published: 2012
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58. Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

Author: Mullins, Niamh, primary, Forstner, Andreas J., additional, O’Connell, Kevin S., additional, Coombes, Brandon, additional, Coleman, Jonathan R. I., additional, Qiao, Zhen, additional, Als, Thomas D., additional, Bigdeli, Tim B., additional, Børte, Sigrid, additional, Bryois, Julien, additional, Charney, Alexander W., additional, Drange, Ole Kristian, additional, Gandal, Michael J., additional, Hagenaars, Saskia P., additional, Ikeda, Masashi, additional, Kamitaki, Nolan, additional, Kim, Minsoo, additional, Krebs, Kristi, additional, Panagiotaropoulou, Georgia, additional, Schilder, Brian M., additional, Sloofman, Laura G., additional, Steinberg, Stacy, additional, Trubetskoy, Vassily, additional, Winsvold, Bendik S., additional, Won, Hong-Hee, additional, Abramova, Liliya, additional, Adorjan, Kristina, additional, Agerbo, Esben, additional, Al Eissa, Mariam, additional, Albani, Diego, additional, Alliey-Rodriguez, Ney, additional, Anjorin, Adebayo, additional, Antilla, Verneri, additional, Antoniou, Anastasia, additional, Awasthi, Swapnil, additional, Baek, Ji Hyun, additional, Bækvad-Hansen, Marie, additional, Bass, Nicholas, additional, Bauer, Michael, additional, Beins, Eva C., additional, Bergen, Sarah E., additional, Birner, Armin, additional, Bøcker Pedersen, Carsten, additional, Bøen, Erlend, additional, Boks, Marco P., additional, Bosch, Rosa, additional, Brum, Murielle, additional, Brumpton, Ben M., additional, Brunkhorst-Kanaan, Nathalie, additional, Budde, Monika, additional, Bybjerg-Grauholm, Jonas, additional, Byerley, William, additional, Cairns, Murray, additional, Casas, Miquel, additional, Cervantes, Pablo, additional, Clarke, Toni-Kim, additional, Cruceanu, Cristiana, additional, Cuellar-Barboza, Alfredo, additional, Cunningham, Julie, additional, Curtis, David, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, Dalkner, Nina, additional, David, Friederike S., additional, Degenhardt, Franziska, additional, Djurovic, Srdjan, additional, Dobbyn, Amanda L., additional, Douzenis, Athanassios, additional, Elvsåshagen, Torbjørn, additional, Escott-Price, Valentina, additional, Ferrier, I. Nicol, additional, Fiorentino, Alessia, additional, Foroud, Tatiana M., additional, Forty, Liz, additional, Frank, Josef, additional, Frei, Oleksandr, additional, Freimer, Nelson B., additional, Frisén, Louise, additional, Gade, Katrin, additional, Garnham, Julie, additional, Gelernter, Joel, additional, Giørtz Pedersen, Marianne, additional, Gizer, Ian R., additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Greenwood, Tiffany A., additional, Grove, Jakob, additional, Guzman-Parra, José, additional, Ha, Kyooseob, additional, Haraldsson, Magnus, additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, Hellgren, Dennis, additional, Herms, Stefan, additional, Hoffmann, Per, additional, Holmans, Peter A., additional, Huckins, Laura, additional, Jamain, Stéphane, additional, Johnson, Jessica S., additional, Kalman, Janos L., additional, Kamatani, Yoichiro, additional, Kennedy, James L., additional, Kittel-Schneider, Sarah, additional, Knowles, James A., additional, Kogevinas, Manolis, additional, Koromina, Maria, additional, Kranz, Thorsten M., additional, Kranzler, Henry R., additional, Kubo, Michiaki, additional, Kupka, Ralph, additional, Kushner, Steven A., additional, Lavebratt, Catharina, additional, Lawrence, Jacob, additional, Leber, Markus, additional, Lee, Heon-Jeong, additional, Lee, Phil H., additional, Levy, Shawn E., additional, Lewis, Catrin, additional, Liao, Calwing, additional, Lucae, Susanne, additional, Lundberg, Martin, additional, MacIntyre, Donald J., additional, Magnusson, Sigurdur H., additional, Maier, Wolfgang, additional, Maihofer, Adam, additional, Malaspina, Dolores, additional, Maratou, Eirini, additional, Martinsson, Lina, additional, Mattheisen, Manuel, additional, McCarroll, Steven A., additional, McGregor, Nathaniel W., additional, McGuffin, Peter, additional, McKay, James D., additional, Medeiros, Helena, additional, Medland, Sarah E., additional, Millischer, Vincent, additional, Montgomery, Grant W., additional, Moran, Jennifer L., additional, Morris, Derek W., additional, Mühleisen, Thomas W., additional, O’Brien, Niamh, additional, O’Donovan, Claire, additional, Loohuis, Loes M. Olde, additional, Oruc, Lilijana, additional, Papiol, Sergi, additional, Pardiñas, Antonio F., additional, Perry, Amy, additional, Pfennig, Andrea, additional, Porichi, Evgenia, additional, Potash, James B., additional, Quested, Digby, additional, Raj, Towfique, additional, Rapaport, Mark H., additional, DePaulo, J. Raymond, additional, Regeer, Eline J., additional, Rice, John P., additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Roth, Julian, additional, Roussos, Panos, additional, Ruderfer, Douglas M., additional, Sánchez-Mora, Cristina, additional, Schulte, Eva C., additional, Senner, Fanny, additional, Sharp, Sally, additional, Shilling, Paul D., additional, Sigurdsson, Engilbert, additional, Sirignano, Lea, additional, Slaney, Claire, additional, Smeland, Olav B., additional, Smith, Daniel J., additional, Sobell, Janet L., additional, Søholm Hansen, Christine, additional, Artigas, Maria Soler, additional, Spijker, Anne T., additional, Stein, Dan J., additional, Strauss, John S., additional, Świątkowska, Beata, additional, Terao, Chikashi, additional, Thorgeirsson, Thorgeir E., additional, Toma, Claudio, additional, Tooney, Paul, additional, Tsermpini, Evangelia-Eirini, additional, Vawter, Marquis P., additional, Vedder, Helmut, additional, Walters, James T. R., additional, Witt, Stephanie H., additional, Xi, Simon, additional, Xu, Wei, additional, Yang, Jessica Mei Kay, additional, Young, Allan H., additional, Young, Hannah, additional, Zandi, Peter P., additional, Zhou, Hang, additional, Zillich, Lea, additional, Psychiatry, HUNT All-In, additional, Adolfsson, Rolf, additional, Agartz, Ingrid, additional, Alda, Martin, additional, Alfredsson, Lars, additional, Babadjanova, Gulja, additional, Backlund, Lena, additional, Baune, Bernhard T., additional, Bellivier, Frank, additional, Bengesser, Susanne, additional, Berrettini, Wade H., additional, Blackwood, Douglas H. R., additional, Boehnke, Michael, additional, Børglum, Anders D., additional, Breen, Gerome, additional, Carr, Vaughan J., additional, Catts, Stanley, additional, Corvin, Aiden, additional, Craddock, Nicholas, additional, Dannlowski, Udo, additional, Dikeos, Dimitris, additional, Esko, Tõnu, additional, Etain, Bruno, additional, Ferentinos, Panagiotis, additional, Frye, Mark, additional, Fullerton, Janice M., additional, Gawlik, Micha, additional, Gershon, Elliot S., additional, Goes, Fernando S., additional, Green, Melissa J., additional, Grigoroiu-Serbanescu, Maria, additional, Hauser, Joanna, additional, Henskens, Frans, additional, Hillert, Jan, additional, Hong, Kyung Sue, additional, Hougaard, David M., additional, Hultman, Christina M., additional, Hveem, Kristian, additional, Iwata, Nakao, additional, Jablensky, Assen V., additional, Jones, Ian, additional, Jones, Lisa A., additional, S. Kahn, René, additional, Kelsoe, John R., additional, Kirov, George, additional, Landén, Mikael, additional, Leboyer, Marion, additional, Lewis, Cathryn M., additional, Li, Qingqin S., additional, Lissowska, Jolanta, additional, Lochner, Christine, additional, Loughland, Carmel, additional, Martin, Nicholas G., additional, Mathews, Carol A., additional, Mayoral, Fermin, additional, McElroy, Susan L., additional, McIntosh, Andrew M., additional, McMahon, Francis J., additional, Melle, Ingrid, additional, Michie, Patricia, additional, Milani, Lili, additional, Mitchell, Philip B., additional, Morken, Gunnar, additional, Mors, Ole, additional, Mortensen, Preben Bo, additional, Mowry, Bryan, additional, Müller-Myhsok, Bertram, additional, Myers, Richard M., additional, Neale, Benjamin M., additional, Nievergelt, Caroline M., additional, Nordentoft, Merete, additional, Nöthen, Markus M., additional, O’Donovan, Michael C., additional, Oedegaard, Ketil J., additional, Olsson, Tomas, additional, Owen, Michael J., additional, Paciga, Sara A., additional, Pantelis, Chris, additional, Pato, Carlos, additional, Pato, Michele T., additional, Patrinos, George P., additional, Perlis, Roy H., additional, Posthuma, Danielle, additional, Ramos-Quiroga, Josep Antoni, additional, Reif, Andreas, additional, Reininghaus, Eva Z., additional, Ribasés, Marta, additional, Rietschel, Marcella, additional, Ripke, Stephan, additional, Rouleau, Guy A., additional, Saito, Takeo, additional, Schall, Ulrich, additional, Schalling, Martin, additional, Schofield, Peter R., additional, Schulze, Thomas G., additional, Scott, Laura J., additional, Scott, Rodney J., additional, Serretti, Alessandro, additional, Weickert, Cynthia Shannon, additional, Smoller, Jordan W., additional, Stefansson, Hreinn, additional, Stefansson, Kari, additional, Stordal, Eystein, additional, Streit, Fabian, additional, Sullivan, Patrick F., additional, Turecki, Gustavo, additional, Vaaler, Arne E., additional, Vieta, Eduard, additional, Vincent, John B., additional, Waldman, Irwin D., additional, Weickert, Thomas W., additional, Werge, Thomas, additional, Wray, Naomi R., additional, Zwart, John-Anker, additional, Biernacka, Joanna M., additional, Nurnberger, John I., additional, Cichon, Sven, additional, Edenberg, Howard J., additional, Stahl, Eli A., additional, McQuillin, Andrew, additional, Di Florio, Arianna, additional, Ophoff, Roel A., additional, and Andreassen, Ole A., additional
Published: 2020
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59. Single Nucleotide Polymorphisms Associated with Methotrexate-induced Nausea in Juvenile Idiopathic Arthritis

Author: Kyvsgaard, Nini, primary, Mikkelsen, Torben Stamm, additional, Als, Thomas D., additional, Christensen, Anne Estmann, additional, Corydon, Thomas J., additional, and Herlin, Troels, additional
Published: 2020
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60. The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

Author: Coleman, Jonathan R.I., primary, Gaspar, Héléna A., additional, Bryois, Julien, additional, Breen, Gerome, additional, Byrne, Enda M., additional, Forstner, Andreas J., additional, Holmans, Peter A., additional, de Leeuw, Christiaan A., additional, Mattheisen, Manuel, additional, McQuillin, Andrew, additional, Whitehead Pavlides, Jennifer M., additional, Pers, Tune H., additional, Ripke, Stephan, additional, Stahl, Eli A., additional, Steinberg, Stacy, additional, Trubetskoy, Vassily, additional, Trzaskowski, Maciej, additional, Wang, Yunpeng, additional, Abbott, Liam, additional, Abdellaoui, Abdel, additional, Adams, Mark J., additional, Adolfsson, Annelie Nordin, additional, Agerbo, Esben, additional, Akil, Huda, additional, Albani, Diego, additional, Alliey-Rodriguez, Ney, additional, Als, Thomas D., additional, Andlauer, Till F.M., additional, Anjorin, Adebayo, additional, Antilla, Verneri, additional, Van der Auwera, Sandra, additional, Awasthi, Swapnil, additional, Bacanu, Silviu-Alin, additional, Badner, Judith A., additional, Bækvad-Hansen, Marie, additional, Barchas, Jack D., additional, Bass, Nicholas, additional, Bauer, Michael, additional, Beekman, Aartjan T.F., additional, Belliveau, Richard, additional, Bergen, Sarah E., additional, Bigdeli, Tim B., additional, Binder, Elisabeth B., additional, Bøen, Erlend, additional, Boks, Marco, additional, Boocock, James, additional, Budde, Monika, additional, Bunney, William, additional, Burmeister, Margit, additional, Buttenschøn, Henriette N., additional, Bybjerg-Grauholm, Jonas, additional, Byerley, William, additional, Cai, Na, additional, Casas, Miquel, additional, Castelao, Enrique, additional, Cerrato, Felecia, additional, Cervantes, Pablo, additional, Chambert, Kimberly, additional, Charney, Alexander W., additional, Chen, Danfeng, additional, Christensen, Jane Hvarregaard, additional, Churchhouse, Claire, additional, St Clair, David, additional, Clarke, Toni-Kim, additional, Colodro-Conde, Lucía, additional, Coryell, William, additional, Couvy-Duchesne, Baptiste, additional, Craig, David W., additional, Crawford, Gregory E., additional, Cruceanu, Cristiana, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, Davies, Gail, additional, Deary, Ian J., additional, Degenhardt, Franziska, additional, Del-Favero, Jurgen, additional, DePaulo, J Raymond, additional, Derks, Eske M., additional, Direk, Nese, additional, Djurovic, Srdjan, additional, Dobbyn, Amanda L., additional, Dolan, Conor V., additional, Dumont, Ashley, additional, Dunn, Erin C., additional, Eley, Thalia C., additional, Elvsåshagen, Torbjørn, additional, Escott-Price, Valentina, additional, Fan, Chun Chieh, additional, Finucane, Hilary K., additional, Fischer, Sascha B., additional, Flickinger, Matthew, additional, Foo, Jerome C., additional, Foroud, Tatiana M., additional, Forty, Liz, additional, Frank, Josef, additional, Fraser, Christine, additional, Freimer, Nelson B., additional, Frisén, Louise, additional, Gade, Katrin, additional, Gage, Diane, additional, Garnham, Julie, additional, Giambartolomei, Claudia, additional, Goes, Fernando S., additional, Goldstein, Jaqueline, additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Green, Elaine K., additional, Green, Melissa J., additional, Greenwood, Tiffany A., additional, Grove, Jakob, additional, Guan, Weihua, additional, Hall, Lynsey S., additional, Hamshere, Marian L., additional, Hansen, Christine Søholm, additional, Hansen, Thomas F., additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, van Hemert, Albert M., additional, Herms, Stefan, additional, Hickie, Ian B., additional, Hipolito, Maria, additional, Hoffmann, Per, additional, Holland, Dominic, additional, Homuth, Georg, additional, Horn, Carsten, additional, Hottenga, Jouke-Jan, additional, Huckins, Laura, additional, Ising, Marcus, additional, Jamain, Stéphane, additional, Jansen, Rick, additional, Johnson, Jessica S., additional, de Jong, Simone, additional, Jorgenson, Eric, additional, Juréus, Anders, additional, Kandaswamy, Radhika, additional, Karlsson, Robert, additional, Kennedy, James L., additional, Hassan Kiadeh, Farnush Farhadi, additional, Kittel-Schneider, Sarah, additional, Knowles, James A., additional, Kogevinas, Manolis, additional, Kohane, Isaac S., additional, Koller, Anna C., additional, Kraft, Julia, additional, Kretzschmar, Warren W., additional, Krogh, Jesper, additional, Kupka, Ralph, additional, Kutalik, Zoltán, additional, Lavebratt, Catharina, additional, Lawrence, Jacob, additional, Lawson, William B., additional, Leber, Markus, additional, Lee, Phil H., additional, Levy, Shawn E., additional, Li, Jun Z., additional, Li, Yihan, additional, Lind, Penelope A., additional, Liu, Chunyu, additional, Olde Loohuis, Loes M., additional, Maaser, Anna, additional, MacIntyre, Donald J., additional, MacKinnon, Dean F., additional, Mahon, Pamela B., additional, Maier, Wolfgang, additional, Maier, Robert M., additional, Marchini, Jonathan, additional, Martinsson, Lina, additional, Mbarek, Hamdi, additional, McCarroll, Steve, additional, McGrath, Patrick, additional, McGuffin, Peter, additional, McInnis, Melvin G., additional, McKay, James D., additional, Medeiros, Helena, additional, Medland, Sarah E., additional, Mehta, Divya, additional, Meng, Fan, additional, Middeldorp, Christel M., additional, Mihailov, Evelin, additional, Milaneschi, Yuri, additional, Milani, Lili, additional, Mirza, Saira Saeed, additional, Mondimore, Francis M., additional, Montgomery, Grant W., additional, Morris, Derek W., additional, Mostafavi, Sara, additional, Mühleisen, Thomas W., additional, Mullins, Niamh, additional, Nauck, Matthias, additional, Ng, Bernard, additional, Nguyen, Hoang, additional, Nievergelt, Caroline M., additional, Nivard, Michel G., additional, Nwulia, Evaristus A., additional, Nyholt, Dale R., additional, O'Donovan, Claire, additional, O'Reilly, Paul F., additional, Ori, Anil P.S., additional, Oruc, Lilijana, additional, Ösby, Urban, additional, Oskarsson, Hogni, additional, Painter, Jodie N., additional, Parra, José Guzman, additional, Pedersen, Carsten Bøcker, additional, Pedersen, Marianne Giørtz, additional, Perry, Amy, additional, Peterson, Roseann E., additional, Pettersson, Erik, additional, Peyrot, Wouter J., additional, Pfennig, Andrea, additional, Pistis, Giorgio, additional, Purcell, Shaun M., additional, Quiroz, Jorge A., additional, Qvist, Per, additional, Regeer, Eline J., additional, Reif, Andreas, additional, Reinbold, Céline S., additional, Rice, John P., additional, Riley, Brien P., additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Roussos, Panos, additional, Ruderfer, Douglas M., additional, Ryu, Euijung, additional, Sánchez-Mora, Cristina, additional, Schatzberg, Alan F., additional, Scheftner, William A., additional, Schoevers, Robert, additional, Schork, Nicholas J., additional, Schulte, Eva C., additional, Shehktman, Tatyana, additional, Shen, Ling, additional, Shi, Jianxin, additional, Shilling, Paul D., additional, Shyn, Stanley I., additional, Sigurdsson, Engilbert, additional, Slaney, Claire, additional, Smeland, Olav B., additional, Smit, Johannes H., additional, Smith, Daniel J., additional, Sobell, Janet L., additional, Spijker, Anne T., additional, Steffens, Michael, additional, Strauss, John S., additional, Streit, Fabian, additional, Strohmaier, Jana, additional, Szelinger, Szabolcs, additional, Tansey, Katherine E., additional, Teismann, Henning, additional, Teumer, Alexander, additional, Thompson, Robert C., additional, Thompson, Wesley, additional, Thomson, Pippa A., additional, Thorgeirsson, Thorgeir E., additional, Traylor, Matthew, additional, Treutlein, Jens, additional, Uitterlinden, André G., additional, Umbricht, Daniel, additional, Vedder, Helmut, additional, Viktorin, Alexander, additional, Visscher, Peter M., additional, Wang, Weiqing, additional, Watson, Stanley J., additional, Webb, Bradley T., additional, Weickert, Cynthia Shannon, additional, Weickert, Thomas W., additional, Weinsheimer, Shantel Marie, additional, Wellmann, Jürgen, additional, Willemsen, Gonneke, additional, Witt, Stephanie H., additional, Wu, Yang, additional, Xi, Hualin S., additional, Xu, Wei, additional, Yang, Jian, additional, Young, Allan H., additional, Zandi, Peter, additional, Zhang, Peng, additional, Zhang, Futao, additional, Zollner, Sebastian, additional, Adolfsson, Rolf, additional, Agartz, Ingrid, additional, Alda, Martin, additional, Arolt, Volker, additional, Backlund, Lena, additional, Baune, Bernhard T., additional, Bellivier, Frank, additional, Berger, Klaus, additional, Berrettini, Wade H., additional, Biernacka, Joanna M., additional, Blackwood, Douglas H.R., additional, Boehnke, Michael, additional, Boomsma, Dorret I., additional, Corvin, Aiden, additional, Craddock, Nicholas, additional, Daly, Mark J., additional, Dannlowski, Udo, additional, Domenici, Enrico, additional, Domschke, Katharina, additional, Esko, Tõnu, additional, Etain, Bruno, additional, Frye, Mark, additional, Fullerton, Janice M., additional, Gershon, Elliot S., additional, de Geus, E.J.C., additional, Gill, Michael, additional, Goes, Fernando, additional, Grabe, Hans J., additional, Grigoroiu-Serbanescu, Maria, additional, Hamilton, Steven P., additional, Hauser, Joanna, additional, Hayward, Caroline, additional, Heath, Andrew C., additional, Hougaard, David M., additional, Hultman, Christina M., additional, Jones, Ian, additional, Jones, Lisa A., additional, Kahn, René S., additional, Kendler, Kenneth S., additional, Kirov, George, additional, Kloiber, Stefan, additional, Landén, Mikael, additional, Leboyer, Marion, additional, Lewis, Glyn, additional, Li, Qingqin S., additional, Lissowska, Jolanta, additional, Lucae, Susanne, additional, Madden, Pamela A.F., additional, Magnusson, Patrik K., additional, Martin, Nicholas G., additional, Mayoral, Fermin, additional, McElroy, Susan L., additional, McIntosh, Andrew M., additional, McMahon, Francis J., additional, Melle, Ingrid, additional, Metspalu, Andres, additional, Mitchell, Philip B., additional, Morken, Gunnar, additional, Mors, Ole, additional, Mortensen, Preben Bo, additional, Müller-Myhsok, Bertram, additional, Myers, Richard M., additional, Neale, Benjamin M., additional, Nimgaonkar, Vishwajit, additional, Nordentoft, Merete, additional, Nöthen, Markus M., additional, O'Donovan, Michael C., additional, Oedegaard, Ketil J., additional, Owen, Michael J., additional, Paciga, Sara A., additional, Pato, Carlos, additional, Pato, Michele T., additional, Pedersen, Nancy L., additional, Penninx, Brenda W.J. H., additional, Perlis, Roy H., additional, Porteous, David J., additional, Posthuma, Danielle, additional, Potash, James B., additional, Preisig, Martin, additional, Ramos-Quiroga, Josep Antoni, additional, Ribasés, Marta, additional, Rietschel, Marcella, additional, Rouleau, Guy A., additional, Schaefer, Catherine, additional, Schalling, Martin, additional, Schofield, Peter R., additional, Schulze, Thomas G., additional, Serretti, Alessandro, additional, Smoller, Jordan W., additional, Stefansson, Hreinn, additional, Stefansson, Kari, additional, Stordal, Eystein, additional, Tiemeier, Henning, additional, Turecki, Gustavo, additional, Uher, Rudolf, additional, Vaaler, Arne E., additional, Vieta, Eduard, additional, Vincent, John B., additional, Völzke, Henry, additional, Weissman, Myrna M., additional, Werge, Thomas, additional, Andreassen, Ole A., additional, Børglum, Anders D., additional, Cichon, Sven, additional, Edenberg, Howard J., additional, Di Florio, Arianna, additional, Kelsoe, John, additional, Levinson, Douglas F., additional, Lewis, Cathryn M., additional, Nurnberger, John I., additional, Ophoff, Roel A., additional, Scott, Laura J., additional, Sklar, Pamela, additional, Sullivan, Patrick F., additional, and Wray, Naomi R., additional
Published: 2020
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61. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Author: Lee, Phil H., primary, Anttila, Verneri, additional, Won, Hyejung, additional, Feng, Yen-Chen A., additional, Rosenthal, Jacob, additional, Zhu, Zhaozhong, additional, Tucker-Drob, Elliot M., additional, Nivard, Michel G., additional, Grotzinger, Andrew D., additional, Posthuma, Danielle, additional, Wang, Meg M.-J., additional, Yu, Dongmei, additional, Stahl, Eli A., additional, Walters, Raymond K., additional, Anney, Richard J.L., additional, Duncan, Laramie E., additional, Ge, Tian, additional, Adolfsson, Rolf, additional, Banaschewski, Tobias, additional, Belangero, Sintia, additional, Cook, Edwin H., additional, Coppola, Giovanni, additional, Derks, Eske M., additional, Hoekstra, Pieter J., additional, Kaprio, Jaakko, additional, Keski-Rahkonen, Anna, additional, Kirov, George, additional, Kranzler, Henry R., additional, Luykx, Jurjen J., additional, Rohde, Luis A., additional, Zai, Clement C., additional, Agerbo, Esben, additional, Arranz, M.J., additional, Asherson, Philip, additional, Bækvad-Hansen, Marie, additional, Baldursson, Gísli, additional, Bellgrove, Mark, additional, Belliveau, Richard A., additional, Buitelaar, Jan, additional, Burton, Christie L., additional, Bybjerg-Grauholm, Jonas, additional, Casas, Miquel, additional, Cerrato, Felecia, additional, Chambert, Kimberly, additional, Churchhouse, Claire, additional, Cormand, Bru, additional, Crosbie, Jennifer, additional, Dalsgaard, Søren, additional, Demontis, Ditte, additional, Doyle, Alysa E., additional, Dumont, Ashley, additional, Elia, Josephine, additional, Grove, Jakob, additional, Gudmundsson, Olafur O., additional, Haavik, Jan, additional, Hakonarson, Hakon, additional, Hansen, Christine S., additional, Hartman, Catharina A., additional, Hawi, Ziarih, additional, Hervás, Amaia, additional, Hougaard, David M., additional, Howrigan, Daniel P., additional, Huang, Hailiang, additional, Kuntsi, Jonna, additional, Langley, Kate, additional, Lesch, Klaus-Peter, additional, Leung, Patrick W.L., additional, Loo, Sandra K., additional, Martin, Joanna, additional, Martin, Alicia R., additional, McGough, James J., additional, Medland, Sarah E., additional, Moran, Jennifer L., additional, Mors, Ole, additional, Mortensen, Preben B., additional, Oades, Robert D., additional, Palmer, Duncan S., additional, Pedersen, Carsten B., additional, Pedersen, Marianne G., additional, Peters, Triinu, additional, Poterba, Timothy, additional, Poulsen, Jesper B., additional, Ramos-Quiroga, Josep Antoni, additional, Reif, Andreas, additional, Ribasés, Marta, additional, Rothenberger, Aribert, additional, Rovira, Paula, additional, Sánchez-Mora, Cristina, additional, Satterstrom, F. Kyle, additional, Schachar, Russell, additional, Artigas, Maria Soler, additional, Steinberg, Stacy, additional, Stefansson, Hreinn, additional, Turley, Patrick, additional, Walters, G. Bragi, additional, Werge, Thomas, additional, Zayats, Tetyana, additional, Arking, Dan E., additional, Bettella, Francesco, additional, Buxbaum, Joseph D., additional, Christensen, Jane H., additional, Collins, Ryan L., additional, Coon, Hilary, additional, De Rubeis, Silvia, additional, Delorme, Richard, additional, Grice, Dorothy E., additional, Hansen, Thomas F., additional, Holmans, Peter A., additional, Hope, Sigrun, additional, Hultman, Christina M., additional, Klei, Lambertus, additional, Ladd-Acosta, Christine, additional, Magnusson, Pall, additional, Nærland, Terje, additional, Nyegaard, Mette, additional, Pinto, Dalila, additional, Qvist, Per, additional, Rehnström, Karola, additional, Reichenberg, Abraham, additional, Reichert, Jennifer, additional, Roeder, Kathryn, additional, Rouleau, Guy A., additional, Saemundsen, Evald, additional, Sanders, Stephan J., additional, Sandin, Sven, additional, St Pourcain, Beate, additional, Stefansson, Kari, additional, Sutcliffe, James S., additional, Talkowski, Michael E., additional, Weiss, Lauren A., additional, Willsey, A. Jeremy, additional, Agartz, Ingrid, additional, Akil, Huda, additional, Albani, Diego, additional, Alda, Martin, additional, Als, Thomas D., additional, Anjorin, Adebayo, additional, Backlund, Lena, additional, Bass, Nicholas, additional, Bauer, Michael, additional, Baune, Bernhard T., additional, Bellivier, Frank, additional, Bergen, Sarah E., additional, Berrettini, Wade H., additional, Biernacka, Joanna M., additional, Blackwood, Douglas H.R., additional, Bøen, Erlend, additional, Budde, Monika, additional, Bunney, William, additional, Burmeister, Margit, additional, Byerley, William, additional, Byrne, Enda M., additional, Cichon, Sven, additional, Clarke, Toni-Kim, additional, Coleman, Jonathan R.I., additional, Craddock, Nicholas, additional, Curtis, David, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, Dalkner, Nina, additional, Dannlowski, Udo, additional, Degenhardt, Franziska, additional, Di Florio, Arianna, additional, Elvsåshagen, Torbjørn, additional, Etain, Bruno, additional, Fischer, Sascha B., additional, Forstner, Andreas J., additional, Forty, Liz, additional, Frank, Josef, additional, Frye, Mark, additional, Fullerton, Janice M., additional, Gade, Katrin, additional, Gaspar, Héléna A., additional, Gershon, Elliot S., additional, Gill, Michael, additional, Goes, Fernando S., additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Green, Melissa J., additional, Greenwood, Tiffany A., additional, Grigoroiu-Serbanescu, Maria, additional, Guzman-Parra, José, additional, Hauser, Joanna, additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, Herms, Stefan, additional, Hoffmann, Per, additional, Holland, Dominic, additional, Jamain, Stéphane, additional, Jones, Ian, additional, Jones, Lisa A., additional, Kandaswamy, Radhika, additional, Kelsoe, John R., additional, Kennedy, James L., additional, Joachim, Oedegaard Ketil, additional, Kittel-Schneider, Sarah, additional, Kogevinas, Manolis, additional, Koller, Anna C., additional, Lavebratt, Catharina, additional, Lewis, Cathryn M., additional, Li, Qingqin S., additional, Lissowska, Jolanta, additional, Loohuis, Loes M.O., additional, Lucae, Susanne, additional, Maaser, Anna, additional, Malt, Ulrik F., additional, Martin, Nicholas G., additional, Martinsson, Lina, additional, McElroy, Susan L., additional, McMahon, Francis J., additional, McQuillin, Andrew, additional, Melle, Ingrid, additional, Metspalu, Andres, additional, Millischer, Vincent, additional, Mitchell, Philip B., additional, Montgomery, Grant W., additional, Morken, Gunnar, additional, Morris, Derek W., additional, Müller-Myhsok, Bertram, additional, Mullins, Niamh, additional, Myers, Richard M., additional, Nievergelt, Caroline M., additional, Nordentoft, Merete, additional, Adolfsson, Annelie Nordin, additional, Nöthen, Markus M., additional, Ophoff, Roel A., additional, Owen, Michael J., additional, Paciga, Sara A., additional, Pato, Carlos N., additional, Pato, Michele T., additional, Perlis, Roy H., additional, Perry, Amy, additional, Potash, James B., additional, Reinbold, Céline S., additional, Rietschel, Marcella, additional, Rivera, Margarita, additional, Roberson, Mary, additional, Schalling, Martin, additional, Schofield, Peter R., additional, Schulze, Thomas G., additional, Scott, Laura J., additional, Serretti, Alessandro, additional, Sigurdsson, Engilbert, additional, Smeland, Olav B., additional, Stordal, Eystein, additional, Streit, Fabian, additional, Strohmaier, Jana, additional, Thorgeirsson, Thorgeir E., additional, Treutlein, Jens, additional, Turecki, Gustavo, additional, Vaaler, Arne E., additional, Vieta, Eduard, additional, Vincent, John B., additional, Wang, Yunpeng, additional, Witt, Stephanie H., additional, Zandi, Peter, additional, Adan, Roger A.H., additional, Alfredsson, Lars, additional, Ando, Tetsuya, additional, Aschauer, Harald, additional, Baker, Jessica H., additional, Bencko, Vladimir, additional, Bergen, Andrew W., additional, Birgegård, Andreas, additional, Perica, Vesna Boraska, additional, Brandt, Harry, additional, Burghardt, Roland, additional, Carlberg, Laura, additional, Cassina, Matteo, additional, Clementi, Maurizio, additional, Courtet, Philippe, additional, Crawford, Steven, additional, Crow, Scott, additional, Crowley, James J., additional, Danner, Unna N., additional, Davis, Oliver S.P., additional, Degortes, Daniela, additional, DeSocio, Janiece E., additional, Dick, Danielle M., additional, Dina, Christian, additional, Docampo, Elisa, additional, Egberts, Karin, additional, Ehrlich, Stefan, additional, Espeseth, Thomas, additional, Fernández-Aranda, Fernando, additional, Fichter, Manfred M., additional, Foretova, Lenka, additional, Forzan, Monica, additional, Gambaro, Giovanni, additional, Giegling, Ina, additional, Gonidakis, Fragiskos, additional, Gorwood, Philip, additional, Mayora, Monica Gratacos, additional, Guo, Yiran, additional, Halmi, Katherine A., additional, Hatzikotoulas, Konstantinos, additional, Hebebrand, Johannes, additional, Helder, Sietske G., additional, Herpertz-Dahlmann, Beate, additional, Herzog, Wolfgang, additional, Hinney, Anke, additional, Imgart, Hartmut, additional, Jiménez-Murcia, Susana, additional, Johnson, Craig, additional, Jordan, Jennifer, additional, Julià, Antonio, additional, Kaminská, Deborah, additional, Karhunen, Leila, additional, Karwautz, Andreas, additional, Kas, Martien J.H., additional, Kaye, Walter H., additional, Kennedy, Martin A., additional, Kim, Youl-Ri, additional, Klareskog, Lars, additional, Klump, Kelly L., additional, Knudsen, Gun Peggy S., additional, Landén, Mikael, additional, Le Hellard, Stephanie, additional, Levitan, Robert D., additional, Li, Dong, additional, Lichtenstein, Paul, additional, Maj, Mario, additional, Marsal, Sara, additional, McDevitt, Sara, additional, Mitchell, James, additional, Monteleone, Palmiero, additional, Monteleone, Alessio Maria, additional, Munn-Chernoff, Melissa A., additional, Nacmias, Benedetta, additional, Navratilova, Marie, additional, O’Toole, Julie K., additional, Padyukov, Leonid, additional, Pantel, Jacques, additional, Papezova, Hana, additional, Rabionet, Raquel, additional, Raevuori, Anu, additional, Ramoz, Nicolas, additional, Reichborn-Kjennerud, Ted, additional, Ricca, Valdo, additional, Roberts, Marion, additional, Rujescu, Dan, additional, Rybakowski, Filip, additional, Scherag, André, additional, Schmidt, Ulrike, additional, Seitz, Jochen, additional, Slachtova, Lenka, additional, Slof-Op‘t Landt, Margarita C.T., additional, Slopien, Agnieszka, additional, Sorbi, Sandro, additional, Southam, Lorraine, additional, Strober, Michael, additional, Tortorella, Alfonso, additional, Tozzi, Federica, additional, Treasure, Janet, additional, Tziouvas, Konstantinos, additional, van Elburg, Annemarie A., additional, Wade, Tracey D., additional, Wagner, Gudrun, additional, Walton, Esther, additional, Watson, Hunna J., additional, Wichmann, H-Erich, additional, Woodside, D. Blake, additional, Zeggini, Eleftheria, additional, Zerwas, Stephanie, additional, Zipfel, Stephan, additional, Adams, Mark J., additional, Andlauer, Till F.M., additional, Berger, Klaus, additional, Binder, Elisabeth B., additional, Boomsma, Dorret I., additional, Castelao, Enrique, additional, Colodro-Conde, Lucía, additional, Direk, Nese, additional, Docherty, Anna R., additional, Domenici, Enrico, additional, Domschke, Katharina, additional, Dunn, Erin C., additional, Foo, Jerome C., additional, de. Geus, E.J.C., additional, Grabe, Hans J., additional, Hamilton, Steven P., additional, Horn, Carsten, additional, Hottenga, Jouke-Jan, additional, Howard, David, additional, Ising, Marcus, additional, Kloiber, Stefan, additional, Levinson, Douglas F., additional, Lewis, Glyn, additional, Magnusson, Patrik K.E., additional, Mbarek, Hamdi, additional, Middeldorp, Christel M., additional, Mostafavi, Sara, additional, Nyholt, Dale R., additional, Penninx, Brenda WJH., additional, Peterson, Roseann E., additional, Pistis, Giorgio, additional, Porteous, David J., additional, Preisig, Martin, additional, Quiroz, Jorge A., additional, Schaefer, Catherine, additional, Schulte, Eva C., additional, Shi, Jianxin, additional, Smith, Daniel J., additional, Thomson, Pippa A., additional, Tiemeier, Henning, additional, Uher, Rudolf, additional, van der Auwera, Sandra, additional, Weissman, Myrna M., additional, Alexander, Madeline, additional, Begemann, Martin, additional, Bramon, Elvira, additional, Buccola, Nancy G., additional, Cairns, Murray J., additional, Campion, Dominique, additional, Carr, Vaughan J., additional, Cloninger, C. Robert, additional, Cohen, David, additional, Collier, David A., additional, Corvin, Aiden, additional, DeLisi, Lynn E., additional, Donohoe, Gary, additional, Dudbridge, Frank, additional, Duan, Jubao, additional, Freedman, Robert, additional, Gejman, Pablo V., additional, Golimbet, Vera, additional, Godard, Stephanie, additional, Ehrenreich, Hannelore, additional, Hartmann, Annette M., additional, Henskens, Frans A., additional, Ikeda, Masashi, additional, Iwata, Nakao, additional, Jablensky, Assen V., additional, Joa, Inge, additional, Jönsson, Erik G., additional, Kelly, Brian J., additional, Knight, Jo, additional, Konte, Bettina, additional, Laurent-Levinson, Claudine, additional, Lee, Jimmy, additional, Lencz, Todd, additional, Lerer, Bernard, additional, Loughland, Carmel M., additional, Malhotra, Anil K., additional, Mallet, Jacques, additional, McDonald, Colm, additional, Mitjans, Marina, additional, Mowry, Bryan J., additional, Murphy, Kieran C., additional, Murray, Robin M., additional, O’Neill, F. Anthony, additional, Oh, Sang-Yun, additional, Palotie, Aarno, additional, Pantelis, Christos, additional, Pulver, Ann E., additional, Petryshen, Tracey L., additional, Quested, Digby J., additional, Riley, Brien, additional, Sanders, Alan R., additional, Schall, Ulrich, additional, Schwab, Sibylle G., additional, Scott, Rodney J., additional, Sham, Pak C., additional, Silverman, Jeremy M., additional, Sim, Kang, additional, Steixner, Agnes A., additional, Tooney, Paul A., additional, van Os, Jim, additional, Vawter, Marquis P., additional, Walsh, Dermot, additional, Weiser, Mark, additional, Wildenauer, Dieter B., additional, Williams, Nigel M., additional, Wormley, Brandon K., additional, Zhang, Fuquan, additional, Androutsos, Christos, additional, Arnold, Paul D., additional, Barr, Cathy L., additional, Barta, Csaba, additional, Bey, Katharina, additional, Bienvenu, O. Joseph, additional, Black, Donald W., additional, Brown, Lawrence W., additional, Budman, Cathy, additional, Cath, Danielle, additional, Cheon, Keun-Ah, additional, Ciullo, Valentina, additional, Coffey, Barbara J., additional, Cusi, Daniele, additional, Davis, Lea K., additional, Denys, Damiaan, additional, Depienne, Christel, additional, Dietrich, Andrea, additional, Eapen, Valsamma, additional, Falkai, Peter, additional, Fernandez, Thomas V., additional, Garcia-Delgar, Blanca, additional, Geller, Daniel A., additional, Gilbert, Donald L., additional, Grados, Marco A., additional, Greenberg, Erica, additional, Grünblatt, Edna, additional, Hagstrøm, Julie, additional, Hanna, Gregory L., additional, Hartmann, Andreas, additional, Hedderly, Tammy, additional, Heiman, Gary A., additional, Heyman, Isobel, additional, Hong, Hyun Ju, additional, Huang, Alden, additional, Huyser, Chaim, additional, Ibanez-Gomez, Laura, additional, Khramtsova, Ekaterina A., additional, Kim, Young Key, additional, Kim, Young-Shin, additional, King, Robert A., additional, Koh, Yun-Joo, additional, Konstantinidis, Anastasios, additional, Kook, Sodahm, additional, Kuperman, Samuel, additional, Leventhal, Bennett L., additional, Lochner, Christine, additional, Ludolph, Andrea G., additional, Madruga-Garrido, Marcos, additional, Malaty, Irene, additional, Maras, Athanasios, additional, McCracken, James T., additional, Meijer, Inge A., additional, Mir, Pablo, additional, Morer, Astrid, additional, Müller-Vahl, Kirsten R., additional, Münchau, Alexander, additional, Murphy, Tara L., additional, Naarden, Allan, additional, Nagy, Peter, additional, Nestadt, Gerald, additional, Nestadt, Paul S., additional, Nicolini, Humberto, additional, Nurmi, Erika L., additional, Okun, Michael S., additional, Paschou, Peristera, additional, Piras, Fabrizio, additional, Piras, Federica, additional, Pittenger, Christopher, additional, Plessen, Kerstin J., additional, Richter, Margaret A., additional, Rizzo, Renata, additional, Robertson, Mary, additional, Roessner, Veit, additional, Ruhrmann, Stephan, additional, Samuels, Jack F., additional, Sandor, Paul, additional, Schlögelhofer, Monika, additional, Shin, Eun-Young, additional, Singer, Harvey, additional, Song, Dong-Ho, additional, Song, Jungeun, additional, Spalletta, Gianfranco, additional, Stein, Dan J., additional, Stewart, S Evelyn, additional, Storch, Eric A., additional, Stranger, Barbara, additional, Stuhrmann, Manfred, additional, Tarnok, Zsanett, additional, Tischfield, Jay A., additional, Tübing, Jennifer, additional, Visscher, Frank, additional, Vulink, Nienke, additional, Wagner, Michael, additional, Walitza, Susanne, additional, Wanderer, Sina, additional, Woods, Martin, additional, Worbe, Yulia, additional, Zai, Gwyneth, additional, Zinner, Samuel H., additional, Sullivan, Patrick F., additional, Franke, Barbara, additional, Daly, Mark J., additional, Bulik, Cynthia M., additional, McIntosh, Andrew M., additional, O’Donovan, Michael C., additional, Zheutlin, Amanda, additional, Andreassen, Ole A., additional, Børglum, Anders D., additional, Breen, Gerome, additional, Edenberg, Howard J., additional, Fanous, Ayman H., additional, Faraone, Stephen V., additional, Gelernter, Joel, additional, Mathews, Carol A., additional, Mattheisen, Manuel, additional, Mitchell, Karen S., additional, Neale, Michael C., additional, Nurnberger, John I., additional, Ripke, Stephan, additional, Santangelo, Susan L., additional, Scharf, Jeremiah M., additional, Stein, Murray B., additional, Thornton, Laura M., additional, Walters, James T.R., additional, Wray, Naomi R., additional, Geschwind, Daniel H., additional, Neale, Benjamin M., additional, Kendler, Kenneth S., additional, and Smoller, Jordan W., additional
Published: 2019
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62. 88 RESULTS: FROM THE FIRST GWAS OF NOCTURNAL ENURESIS AND ASSESSMENT OF THE GENETIC OVERLAP WITH PSYCHIATRIC DISORDERS

Author: Jørgensen, Cecilie S., primary, Horsdal, Henriette T., additional, Rajagopal, Veera, additional, Agerbo, Esben, additional, Als, Thomas D., additional, Børglum, Anders, additional, Demontis, Ditte, additional, Grove, Jakob, additional, Kamperis, Konstantinos, additional, Rittig, Søren, additional, Stefansson, Hreinn, additional, Walters, Bragi, additional, and Christensen, Jane Hvarregaard, additional
Published: 2019
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63. Assembly and analysis of 100 full MHC haplotypes from the Danish population

Author: Jensen, Jacob M., Villesen, Palle, Friborg, Rune M., Mailund, Thomas, Besenbacher, Søren, Sørensen, Lasse Maretty, Petersen, Bent, Sibbesen, Jonas Andreas, Liu, Siyang, Skov, Laurits, Belling, Kirstine G, Have, Christian Theil, Izarzugaza, Jose M. G., Grosjean, Marie, Bork-Jensen, Jette, Grove, Jakob, Als, Thomas D., Huang, Shujia, Chang, Yuqi, Xu, Ruiqi, Ye, Weijian, Rao, Junhua, Guo, Xiaosen, Sun, Jihua, Cao, Hongzhi, Ye, Chen, Beusekom, Johan V., Espeseth, Thomas, Flindt, Esben, Halager, Anders E., Hellard, Stephanie Le, Hultman, Christina M., Lescai, Francesco, Li, Shengting, Lund, Ole, Løngren, Peter, Matey-Hernandez, Maria Luisa, Mors, Ole, Pedersen, Christian N. S., Sicheritz-Pontén, Thomas, Sullivan, Patrick, Syed, Ali, Westergaard, David, Yadav, Rachita, Li, Ning, Xu, Xun, Hansen, Torben, Bolund, Lars, Krogh, Anders, Sørensen, Thorkild I. A., Pedersen, Oluf Borbye, Gupta, Ramneek, Rasmussen, Simon, Børglum, Anders D., Wang, Jun, Eiberg, Hans Rudolf Lytchoff, Kristiansen, Karsten, Brunak, Søren, and Schierup, Mikkel Heide
Subjects: Resource, 0301 basic medicine, Linkage disequilibrium, Denmark, Human leukocyte antigen, Biology, Balancing selection, Major histocompatibility complex, Polymorphism, Single Nucleotide, Genome, Linkage Disequilibrium, Major Histocompatibility Complex, 03 medical and health sciences, 0302 clinical medicine, Journal Article, Genetics, Humans, Alleles, Genetics (clinical), Haplotype, Chromosome Mapping, Genetic Variation, Genetics, Population, 030104 developmental biology, Haplotypes, Evolutionary biology, biology.protein, 030217 neurology & neurosurgery, Imputation (genetics), Reference genome
Abstract: Genes in the major histocompatibility complex (MHC, also known as HLA) play a critical role in the immune response and variation within the extended 4-Mb region shows association with major risks of many diseases. Yet, deciphering the underlying causes of these associations is difficult because the MHC is the most polymorphic region of the genome with a complex linkage disequilibrium structure. Here, we reconstruct full MHC haplotypes from de novo assembled trios without relying on a reference genome and perform evolutionary analyses. We report 100 full MHC haplotypes and call a large set of structural variants in the regions for future use in imputation with GWAS data. We also present the first complete analysis of the recombination landscape in the entire region and show how balancing selection at classical genes have linked effects on the frequency of variants throughout the region.
Published: 2017

64. Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (Nature Genetics, (2019), 51, 4, (659-674), 10.1038/s41588-019-0364-4)

Author: Huckins, Laura M., Dobbyn, Amanda, Ruderfer, Douglas M., Hoffman, Gabriel, Wang, Weiqing, Pardiñas, Antonio F., Rajagopal, Veera M., Als, Thomas D., t. Nguyen, Hoang, Girdhar, Kiran, Boocock, James, Roussos, Panos, Fromer, Menachem, Kramer, Robin, Domenici, Enrico, Gamazon, Eric R., Purcell, Shaun, Demontis, Ditte, Børglum, Anders D., Walters, James T. R., C. O’Donovan, Michael, Sullivan, Patrick, Owen, Michael J., Devlin, Bernie, Sieberts, Solveig K., Cox, Nancy J., Im, Hae Kyung, Sklar, Pamela, and Stahl, Eli A.
Subjects: health services administration, genetic processes, information science, natural sciences, health care economics and organizations
Abstract: In the HTML version of the article originally published, the author group ‘The Schizophrenia Working Group of the Psychiatric Genomics Consortium’ was displayed incorrectly. The error has been corrected in the HTML version of the article.
Published: 2019

65. Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population

Author: Musliner, Katherine L., Mortensen, Preben B., McGrath, John J., Suppli, Nis P., Hougaard, David M., Bybjerg-Grauholm, Jonas, Baekvad-Hansen, Marie, Andreassen, Ole, Pedersen, Carsten B., Pedersen, Marianne G., Mors, Ole, Nordentoft, Merete, Borglum, Anders D., Werge, Thomas, Agerbo, Esben, Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R., I, Gaspar, Helena A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M. Whitehead, Trzaskowski, Maciej, Pers, Tune H., Holmans, Peter A., Abbott, Liam, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Etzekvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E., Pedersen, Carsten Bocker, Boen, Erlend, Boks, Marco, Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Byerley, William, Casas, Miguel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Chamey, Alexander W., Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coryell, William, Craig, David W., Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M., Dale, Anders M., de Jong, Simone, Degenhardt, Franziska, Del-Favero, Jurgen, DePaulo, J. Raymond, Djurovic, Srdjan, Dobbyn, Amanda L., Dumont, Ashley, Elvsashagen, Torbjorn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B., Flickinger, Matthew, Foroud, Tatiana M., Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B., Frisen, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartobmei, Claudia, Pedersen, Marianne Giortz, Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tiffany A., Grove, Jakob, Guan, Weihua, Parra, Jose Guzman, Hamshere, Marian L., Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Huckins, Laura, Jamain, Stephan, Johnson, Jessica S., Jureus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Kittel-Schneider, Sarah, Knott, Sarah, V, Knowles, James A., Kogevinas, Manolis, Koller, Anna C., Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J., Mahon, Pamela B., Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Meng, Fan, Milani, Lili, Montgomery, Grant W., Morris, Derek W., Muehleisen, Thomas W., Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M., Adolfsson, Annelie Nordin, Nwulia, Evaristus A., O'Donovan, Claire, Loohuis, Loes M. Olde, Ori, Anil P. S., Oruc, Lilijana, Osby, Urban, Perlis, Roy H., Perry, Amy, Pfennig, Andrea, Potash, James B., Purcell, Shaun M., Regeer, Eline J., Reif, Andreas, Reinbold, Celine S., Rice, John P., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sanchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schork, Nicholas J., Weickert, Cynthia Shannon, Shehktman, Tatyana, Shilling, Paul D., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav B., Sobell, Janet L., Hansen, Christine Soholm, Spijker, Anne T., St Clair, David, Steffens, Michael, Strauss, John S., Streit, Fabian, Strohmaier, Jana, Szelinger, Szabolcs, Thompson, Robert C., Thorgeirsson, Thorgeir E., Treutlein, Jens, Vedder, Helmut, Wang, Weiqing, Watson, Stanley J., Weickert, Thomas W., Witt, Stephanie H., Xi, Simon, Xu, Wei, Young, Allan H., Zandi, Peter, Zhang, Peng, Zollner, Sebastian, Agartz, Ingrid, Aida, Martin, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berrettini, Wade H., Biemacka, Joanna M., Blackwood, Douglas H. R., Boehnke, Michael, Berglum, Anders D., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Esko, Tonu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gershon, Elliot S., Goes, Fernando, Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Hultman, Christina M., Jones, Ian, Jones, Lisa A., Kahn, Rene S., Kirov, George, Landen, Mikael, Leboyer, Marion, Lewis, Cathryn M., Li, Qingqin S., Lissowska, Jolanta, Martin, Nicholas G., Mayoral, Fermin, McElroy, Susan L., McIntosh, Andrew M., McMahon, Francis J., Melle, Ingrid, Metspalu, Andres, Mitchell, Philip B., Morken, Gunnar, Mortensen, Preben Bo, Mueller-Myhsok, Bertram, Myers, Richard M., Neale, Benjamin M., Nimgaonkar, Vishwajit, Noethen, Markus M., O'Donovan, Michael C., Oedegaard, Ketil J., Owen, Michael, Paciga, Sara A., Pato, Carlos, Pato, Michele T., Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Ribases, Marta, Rietschel, Marcella, Rouleau, Guy A., Schalling, Martin, Schofield, Peter R., Schulze, Thomas G., Serretti, Alessandro, Smoller, Jordan W., Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Sullivan, Patrick F., Turecki, Gustavo, Vaaler, Arne E., Ieta, Eduard, V, Vincent, John B., Nurnberger, John, I, Wray, Naomi R., Di Florio, Arianna, Edenberg, Howard J., Cichon, Sven, Ophoff, Roel A., Scott, Laura J., Andreassen, Ole A., Kelsoe, John, Sklar, Pamela, and Psychiat Genomics Consortium
Subjects: Adult, Male, medicine.medical_specialty, Multifactorial Inheritance, Bipolar Disorder, Adolescent, Denmark, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Risk Factors, medicine, Journal Article, Humans, Genetic Predisposition to Disease, Bipolar disorder, Young adult, Association (psychology), Psychiatry, Child, Depression (differential diagnoses), Proportional Hazards Models, Depressive Disorder, Major, Proportional hazards model, business.industry, Depression, Case-control study, Age Factors, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Schizophrenia, Case-Control Studies, Linear Models, Major depressive disorder, Female, Human medicine, business, 030217 neurology & neurosurgery
Abstract: Importance: Although the usefulness of polygenic risk scores as a measure of genetic liability for major depression (MD) has been established, their association with depression in the general population remains relatively unexplored.Objective: To evaluate whether polygenic risk scores for MD, bipolar disorder (BD), and schizophrenia (SZ) are associated with depression in the general population and explore whether these polygenic liabilities are associated with heterogeneity in terms of age at onset and severity at the initial depression diagnosis.Design, Setting, and Participants: Participants were drawn from the Danish iPSYCH2012 case-cohort study, a representative sample drawn from the population of Denmark born between May 1, 1981, and December 31, 2005. The hazard of depression was estimated using Cox regressions modified to accommodate the case-cohort design. Case-only analyses were conducted using linear and multinomial regressions. The data analysis was conducted from February 2017 to June 2018.Exposures: Polygenic risk scores for MD, BD, and SZ trained using the most recent genome-wide association study results from the Psychiatric Genomics Consortium.Main Outcomes and Measures: The main outcome was first depressive episode (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ICD-10] code F32) treated in hospital-based psychiatric care. Severity at the initial diagnosis was measured using the ICD-10 code severity specifications (mild, moderate, severe without psychosis, and severe with psychosis) and treatment setting (inpatient, outpatient, and emergency).Results: Of 34 573 participants aged 10 to 31 years at censoring, 68% of those with depression were female compared with 48.9% of participants without depression. Each SD increase in polygenic liability for MD, BD, and SZ was associated with 30% (hazard ratio [HR], 1.30; 95% CI, 1.27-1.33), 5% (HR, 1.05; 95% CI, 1.02-1.07), and 12% (HR, 1.12; 95% CI, 1.09-1.15) increases in the hazard of depression, respectively. Among cases, a higher polygenic liability for BD was associated with earlier depression onset (β = -.07; SE = .02; P = .002).Conclusions and Relevance: Polygenic liability for MD is associated with first depression in the general population, which supports the idea that these scores tap into an underlying liability for developing the disorder. The fact that polygenic risk for BD and polygenic risk for SZ also were associated with depression is consistent with prior evidence that these disorders share some common genetic overlap. Variations in polygenic liability may contribute slightly to heterogeneity in clinical presentation, but these associations appear minimal.
Published: 2019

66. Publisher Correction:Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection (Nature Genetics, (2018), 50, 3, (381-389), 10.1038/s41588-018-0059-2)

Author: Pardiñas, Antonio F., Holmans, Peter, Pocklington, Andrew J., Escott-Price, Valentina, Ripke, Stephan, Carrera, Noa, Legge, Sophie E., Bishop, Sophie, Cameron, Darren, Hamshere, Marian L., Han, Jun, Hubbard, Leon, Lynham, Amy, Mantripragada, Kiran, Rees, Elliott, MacCabe, James H., McCarroll, Steven A., Baune, Bernhard T., Breen, Gerome, Byrne, Enda M., Dannlowski, Udo, Eley, Thalia C., Hayward, Caroline, Martin, Nicholas G., McIntosh, Andrew M., Plomin, Robert, Porteous, David J., Wray, Naomi R., Agerbo, Esben, Als, Thomas D., Mortensen, Preben Bo, Pedersen, Carsten B., Børglum, Anders D., Pedersen, Marianne Giørtz, Grove, Jakob, Mattheisen, Manuel, Mors, Ole, Hansen, Christine Søholm, Morris, John C., Achilla, Evanthia, Gasse, Christiane, Horsdal, Henriette Thisted, Köhler, Ole, Meier, Sandra M., and Støvring, Henrik
Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Published: 2019

67. Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Author: Huckins, Laura M. Dobbyn, Amanda Ruderfer, Douglas M. and Hoffman, Gabriel Wang, Weiqing Pardinas, Antonio F. and Rajagopal, Veera M. Als, Thomas D. Nguyen, Hoang T. Girdhar, Kiran Boocock, James Roussos, Panos Fromer, Menachem and Kramer, Robin Domenici, Enrico Gamazon, Eric R. Purcell, Shaun Demontis, Ditte Borglum, Anders D. Walters, James T. R. O'Donovan, Michael C. Sullivan, Patrick Owen, Michael J. and Devlin, Bernie Sieberts, Solveig K. Cox, Nancy J. Im, Hae Kyung Sklar, Pamela Stahl, Eli A. Johnson, Jessica S. and Shah, Hardik R. Klein, Lambertus L. Dang, Kristen K. and Logsdon, Benjamin A. Mahajan, Milind C. Mangravite, Lara M. and Toyoshiba, Hiroyoshi Gur, Raquel E. Hahn, Chang-Gyu Schadt, Eric Lewis, David A. Haroutunian, Vahram Peters, Mette A. and Lipska, Barbara K. Buxbaum, Joseph D. Hirai, Keisuke and Perumal, Thanneer M. Essioux, Laurent Rajagopal, Veera Manikandan Mattheisen, Manuel Grove, Jakob Werge, Thomas and Mortensen, Preben Bo Pedersen, Carsten Bocker Agerbo, Esben and Pedersen, Marianne Giortz Mors, Ole Nordentoft, Merete and Hougaard, David M. Bybjerg-Grauholm, Jonas Baekvad-Hansen, Marie and Hansen, Christine Soholm Ripke, Stephan Neale, Benjamin M. and Corvin, Aiden Farh, Kai-How Holmans, Peter A. Lee, Phil and Bulik-Sullivan, Brendan Collier, David A. Huang, Hailiang and Pers, Tune H. Agartz, Ingrid Albus, Margot Alexander, Madeline Amin, Farooq Bacanu, Silviu A. Begemann, Martin and Belliveau, Jr., Richard A. Bene, Judit Bergen, Sarah E. and Bevilacqua, Elizabeth Bigdeli, Tim B. Black, Donald W. and Bruggeman, Richard Buccola, Nancy G. Buckner, Randy L. and Byerley, William Cahn, Wiepke Cai, Guiqing Campion, Dominique Cantor, Rita M. Carr, Vaughan J. Carrera, Noa and Catts, V, Stanley Chambert, Kimberly D. Chan, Raymond C. K. and Chen, Ronald Y. L. Chen, Eric Y. H. Cheng, Wei Cheung, Eric F. C. Chong, Siow Ann Cloninger, C. Robert Cohen, David and Cohen, Nadine Cormican, Paul Craddock, Nick Crowley, James J. Curtis, David Davidson, Michael Davis, Kenneth L. and Degenhardt, Franziska Del Favero, Jurgen Dikeos, Dimitris and Dinan, Timothy Djurovic, Srdjan Donohoe, Gary Drapeau, Elodie Duan, Jubao Dudbridge, Frank Durmishi, Naser and Eichhammer, Peter Eriksson, Johan Escott-Price, Valentina and Essioux, Laurent Fanous, Ayman H. Farrell, Martilias S. and Frank, Josef Franke, Lude Freedman, Robert Freimer, Nelson B. Friedl, Marion Friedman, I, Joseph Fromer, Menachem and Genovese, Giulio Georgieva, Lyudmila Giegling, Ina and Giusti-Rodriguez, Paola Godard, Stephanie Goldstein, I, Jacqueline Golimbet, Vera Gopal, Srihari Gratten, Jacob and de Haan, Lieuwe Hammer, Christian Hamshere, Marian L. and Hansen, Mark Hansen, Thomas Haroutunian, Vahram Hartmann, Annette M. Henskens, Frans A. Herms, Stefan Hirschhorn, Joel N. Hoffmann, Per Hofman, Andrea Hollegaard, V, Mads and Ikeda, Masashi Joa, Inge Julia, Antonio Kahn, Rene S. and Kalaydjieva, Luba Karachanak-Yankova, Sena Karjalainen, Juha and Kavanagh, David Keller, Matthew C. Kennedy, James L. and Khrunin, Andrey Kim, Yunjung Klovins, Janis Knowles, James A. Konte, Bettina Kucinskas, Vaidutis Kucinskiene, Zita Ausrele Kuzelova-Ptackova, Hana Kahler, Anna K. Laurent, Claudine Keong, Jimmy Lee Chee Lee, S. Hong Legge, Sophie E. and Lerer, Bernard Li, Miaoxin Li, Tao Liang, Kung-Yee and Lieberman, Jeffrey Limborska, Svetlana Loughland, Carmel M. and Lubinski, Jan Lonnqvist, Jouko Macek, Jr., Milan Magnusson, Patrik K. E. Maher, Brion S. Maier, Wolfgang Mallet, Jacques and Marsal, Sara Mattingsdal, Morten McCarley, Robert W. and McDonald, Colm McIntosh, Andrew M. Meier, Sandra Meijer, Carin J. Melegh, Bela Melle, Ingrid Mesholam-Gately, I, Raquelle Metspalu, Andres Michie, Patricia T. Milani, Lili and Milanova, Vihra Mokrab, Younes Morris, Derek W. Mors, Ole Murphy, Kieran C. Murray, Robin M. Myin-Germeys, Inez and Muller-Myhsok, Bertram Nelis, Mari Nenadic, Igor and Nertney, Deborah A. Nestadt, Gerald Nicodemus, Kristin K. and Nikitina-Zake, Liene Nisenbaum, Laura Nordin, Annelie and O'Callaghan, Eadbhard O'Dushlaine, Colm O'Neill, F. Anthony and Oh, Sang-Yun Olincy, Ann Olsen, Line Van Os, Jim and Pantelis, Christos Papadimitriou, George N. Papiol, Sergi and Parkhomenko, Elena Pato, Michele T. Paunio, Tiina and Pejovic-Milovancevic, Milica Perkins, Diana O. Pietilainen, Olli and Pimm, Jonathan Pocklington, Andrew J. Powell, John and Price, Alkes Pulver, Ann E. Purcell, Shaun M. Quested, Digby and Rasmussen, Henrik B. Reichenberg, Abraham Reimers, Mark A. and Richards, Alexander L. Roffman, Joshua L. Ruderfer, Douglas M. Salomaa, Veikko Sanders, Alan R. Schall, Ulrich and Schubert, Christian R. Schulze, Thomas G. Schwab, Sibylle G. and Scolnick, Edward M. Scott, Rodney J. Seidman, Larry J. Shi, Jianxin Sigurdsson, Engilbert Silagadze, Teimuraz Silverman, Jeremy M. Sim, Kang Slominsky, Petr Smoller, Jordan W. and So, Hon-Cheong Spencer, Chris C. A. Stefansson, Hreinn and Steinberg, Stacy Stogmann, Elisabeth Straub, Richard E. and Strengman, Eric Strohmaier, Jana Stroup, T. Scott and Subramaniam, Mythily Suvisaari, Jaana Svrakic, Dragan M. and Szatkiewicz, Jin P. Soderman, Erik Thirumalai, Srinivas and Toncheva, Draga Tosato, Sarah Veijola, Juha Waddington, John and Walsh, Dermot Wang, Dai Wang, Qiang Webb, Bradley T. and Weiser, Mark Wildenauer, Dieter B. Williams, Nigel M. and Williams, Stephanie Witt, Stephanie H. Wolen, Aaron R. Wong, Emily H. M. Wormley, Brandon K. Xi, Hualin Simon Zai, Clement C. Zheng, Xuebin Zimprich, Fritz Wray, Naomi R. and Stefansson, Kari Visscher, Peter M. Adolfsson, Rolf and Andreassen, Ole A. Blackwood, Douglas H. R. Bramon, Elvira and Buxbaum, Joseph D. Borglum, Anders D. Cichon, Sven Darvasi, Ariel Domenici, Enrico Ehrenreich, Hannelore Esko, Tonu and Gejman, V, Pablo Gill, Michael Gurling, Hugh Hultman, Christina M. Iwata, Nakao Jablensky, V, Assen Jonsson, Erik G. Kendler, Kenneth S. Kirov, George Knight, Jo Lencz, Todd Levinson, Douglas F. Li, Qingqin S. Liu, Jianjun and Malhotra, Anil K. McCarroll, Steven A. McQuillin, Andrew and Moran, Jennifer L. Mortensen, Preben B. Mowry, Bryan J. and Nothen, Markus M. Ophoff, Roel A. Owen, Michael J. Palotie, Aarno Pato, Carlos N. Petryshen, Tracey L. Posthuma, Danielle Rietschel, Marcella Riley, Brien P. Rujescu, Dan and Sham, Pak C. St Clair, David Weinberger, Daniel R. and Wendland, Jens R. Werge, Thomas Daly, Mark J. Sullivan, Patrick F. CommonMind Consortium Psychiat Genomics Consortium and iPSYCH-GEMS Schizophrenia Working
Abstract: Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression.
Published: 2019

68. Publisher Correction:Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (Nature Genetics, (2019), 51, 4, (659-674), 10.1038/s41588-019-0364-4)

Author: Huckins, Laura M., Dobbyn, Amanda, Ruderfer, Douglas M., Hoffman, Gabriel, Wang, Weiqing, Pardiñas, Antonio F., Rajagopal, Veera M., Als, Thomas D., T. Nguyen, Hoang, Girdhar, Kiran, Boocock, James, Roussos, Panos, Fromer, Menachem, Kramer, Robin, Domenici, Enrico, Gamazon, Eric R., Purcell, Shaun, Johnson, Jessica S., Shah, Hardik R., Klein, Lambertus L., Dang, Kristen K., Logsdon, Benjamin A., Mahajan, Milind C., Agerbo, Esben, Demontis, Ditte, Hansen, Mark, Hansen, Thomas, Hollegaard, Mads V., Mattheisen, Manuel, Meier, Sandra, Mors, Ole, Rasmussen, Henrik B., Stahl, Eli A., Børglum, Anders D., Mortensen, Preben Bo, Grove, Jakob, Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, and Hansen, Christine Søholm
Abstract: In the HTML version of the article originally published, the author group ‘The Schizophrenia Working Group of the Psychiatric Genomics Consortium’ was displayed incorrectly. The error has been corrected in the HTML version of the article.
Published: 2019

69. Genome-wide association study identifies 30 loci associated with bipolar disorder

Author: Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R.I., Gaspar, Héléna A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M. Whitehead, Trzaskowski, Maciej, Byrne, Enda M., Pers, Tune H., Holmans, Peter A., Richards, Alexander L., Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Bækvad-Hansen, Marie, Barchas, Jack D., Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E., Pedersen, Carsten Bøcker, Bøen, Erlend, Boks, Marco P., Boocock, James, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alxander W., Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coryell, William, Craig, David W., Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M., Dale, Anders, de Jong, Simone, Degenhardt, Franziska, Del-Favero, Jurgen, Depaulo, J. Raymond, Djurovic, Srdjan, Dobbyn, Amanda L., Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B., Flickinger, Matthew, Foroud, Tatiana M., Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B., Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Giambartolomei, Claudia, Pedersen, Marianne Giørtz, Goldstein, Jaqueline, Gordon, Scott D., Gordon-Smith, Katherine, Green, Elaine K., Green, Melissa J., Greenwood, Tifany A., Grove, Jakob, Guan, Weihua, Guzman-Parra, José, Hamshere, Marian L., Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S., Juréus, Anders, Kandaswamy, Radhika, Karlsson, Robert, Kennedy, James L., Kittel-Schneider, Sarah, Knowles, James A., Kogevinas, Manolis, Koller, Anna C., Kupka, Ralph, Lavebratt, Catharina, Lawrence, Jacob, Lawson, William B., Leber, Markus, Lee, Phil H., Levy, Shawn E., Li, Jun Z., Liu, Chunyu, Lucae, Susanne, Maaser, Anna, MacIntyre, Donald J., Mahon, Pamela B., Maier, Wolfgang, Martinsson, Lina, McCarroll, Steve, McGuffin, Peter, McInnis, Melvin G., McKay, James D., Medeiros, Helena, Medland, Sarah E., Meng, Fan, Milani, Lili, Montgomery, Grant W., Morris, Derek W., Mühleisen, Thomas W., Mullins, Niamh, Nguyen, Hoang, Nievergelt, Caroline M., Adolfsson, Annelie Nordin, Nwulia, Evaristus A., O'Donovan, Claire, Loohuis, Loes M. Olde, Ori, Anil P.S., Oruc, Lilijana, Ösby, Urban, Perlis, Roy H., Perry, Amy, Pfennig, Andrea, Potash, James B., Purcell, Shaun M., Regeer, Eline J., Reif, Andreas, Reinbold, Céline S., Rice, John P., Rivas, Fabio, Rivera, Margarita, Roussos, Panos, Ruderfer, Douglas M., Ryu, Euijung, Sánchez-Mora, Cristina, Schatzberg, Alan F., Scheftner, William A., Schork, Nicholas J., Shannon Weickert, Cynthia, Shehktman, Tatyana, Shilling, Paul D., Sigurdsson, Engilbert, Slaney, Claire, Smeland, Olav Bjerkehagen, Sobell, Janet L., Søholm Hansen, Christine, Spijker, Anne T., St Clair, David, Steffens, Michael, Strauss, John S., Streit, Fabian, Strohmaier, Jana, Szelinger, Szabolcs, Thompson, Robert C., Thorgeirsson, Thorgeir E, Treutlein, Jens, Vedder, Helmut, Wang, Weiqing, Watson, Stanley J., Weickert, Thomas W., Witt, Stephanie H., Xi, Simon, Xu, Wei, Young, Allan H., Zandi, Peter, Zhang, Peng, Zöllner, Sebastian, Adolfsson, Rolf, Agartz, Ingrid, Alda, Martin, Backlund, Lena, Baune, Bernhard T., Bellivier, Frank, Berrettini, Wade H., Biernacka, Joanna M., Blackwood, Douglas H.R., Boehnke, Michael, Børglum, Anders D., Corvin, Aiden, Craddock, Nicholas, Daly, Mark J., Dannlowski, Udo, Esko, Tõnu, Etain, Bruno, Frye, Mark, Fullerton, Janice M., Gershon, Elliot S., Gill, Michael, Goes, Fernando, Grigoroiu-Serbanescu, Maria, Hauser, Joanna, Hougaard, David M., Hultman, Christina M., Jones, Ian, Jones, Lisa A., Kahn, René S., Kirov, George, Landén, Mikael, Leboyer, Marion, Lewis, Cathryn M., Li, Qingqin S., Lissowska, Jolanta, Martin, Nicholas G., Mayoral, Fermin, McElroy, Susan L., McIntosh, Andrew M., McMahon, Francis J., Melle, Ingrid, Metspalu, Andres, Mitchell, Philip B., Morken, Gunnar, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Myers, Richard M., Neale, Benjamin M., Nimgaonkar, Vishwajit, Nordentoft, Merete, Nöthen, Markus M., O'Donovan, Michael C, Ødegaard, Ketil Joachim, Owen, Michael J., Paciga, Sara A., Pato, Carlos, Pato, Michele T., Posthuma, Danielle, Ramos-Quiroga, Josep Antoni, Ribasés, Marta, Rietschel, Marcella, Rouleau, Guy A., Schalling, Martin, Schofield, Peter R., Schulze, Thomas G., Serretti, Alessandro, Smoller, Jordan W., Stefansson, Hreinn, Stefansson, Kari, Stordal, Eystein, Sullivan, Patrick F., Turecki, Gustavo, Vaaler, Arne, Vieta, Eduard, Vincent, John B., Werge, Thomas, Nurnberger, John I., Wray, Naomi R., Di Florio, Arianna, Edenberg, Howard J., Cichon, Sven, Ophoff, Roel A., Scott, Laura J., Andreassen, Ole Andreas, Kelsoe, John, and Sklar, Pamela
Abstract: Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P
Published: 2019

70. Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Author: Ruderfer, Douglas M., Ripke, Stephan, McQuillin, Andrew, Boocock, James, Stahl, Eli A., Pavlides, Jennifer M.Whitehead, Mullins, Niamh, Charney, Alexander W., Ori, Anil P.S., Loohuis, Loes M.Olde, Domenici, Enrico, Di Florio, Arianna, Papiol, Sergi, Kalman, Janos L., Trubetskoy, Vassily, Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Akil, Huda, Albani, Diego, Albus, Margot, Alda, Martin, Alexander, Madeline, Alliey-Rodriguez, Ney, Als, Thomas D., Amin, Farooq, Anjorin, Adebayo, Arranz, Maria J., Awasthi, Swapnil, Bacanu, Silviu A., Badner, Judith A., Baekvad-Hansen, Marie, Bakker, Steven, Band, Gavin, Barchas, Jack D., Barroso, Ines, Bass, Nicholas, Bauer, Michael, Baune, Bernhard T., Begemann, Martin, Bellenguez, Celine, Belliveau, Richard A., Bellivier, Frank, Bender, Stephan, Boks, Marco, Cahn, Wiepke, Kahn, Rene S., Van Os, Jim, Strengman, Eric, Ophoff, Roel A., Psychosis Endophenotypes International Consortium, Wellcome Trust Case-Control Consortium, and Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium douglas.ruderfer@vanderbilt.edu
Subjects: bipolar disorder, schizophrenia, polygenic risk, Biochemistry, Genetics and Molecular Biology(all), psychosis, subphenotypes
Abstract: Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585 SCZ, 15,270 BD) identified four genomic regions including one with disorder-independent causal variants and potassium ion response genes as contributing to differences in biology between the disorders. Polygenic risk score (PRS) analyses identified several significant correlations within case-only phenotypes including SCZ PRS with psychotic features and age of onset in BD. For the first time, we discover specific loci that distinguish between BD and SCZ and identify polygenic components underlying multiple symptom dimensions. These results point to the utility of genetics to inform symptomology and potential treatment. Genetic analysis of multiple bipolar disorder and schizophrenia cohorts reveals loci and polygenic risk scores that differentiate the clinical symptoms of these two highly correlated disorders.
Published: 2018

71. Benchmarking the HLA typing performance of Polysolver and Optitype in 50 Danish parental trios

Author: Matey-Hernandez, María Luisa, Maretty, Lasse, Jensen, Jacob Malte, Petersen, Bent, Andreas Sibbesen, Jonas, Liu, Siyang, Villesen, Palle, Skov, Laurits, Belling, Kirstine, Theil Have, Christian, Gonzalez-Izarzugaza, Jose Maria, Grosjean, Marie, Bork-Jensen, Jette, Grove, Jakob, Als, Thomas D., Huang, Shujia, Chang, Yuqi, Xu, Ruiqi, Ye, Weijian, Rao, Junhua, Guo, Xiaosen, Sun, Jihua, Cao, Hongzhi, Ye, Chen, Beusekom, Johan v., Espeseth, Thomas, Flindt, Esben N., Friborg, Rune M., Halager, Anders Egerup, Le Hellard, Stephanie, Hultman, Christina M., Lescai, Francesco, Li, Shengting, Lund, Ole, Løngren, Peter, Mailund, Thomas, Mors, Ole, Pedersen, Christian N. S., Sicheritz-Pontén, Thomas, Sullivan, Patrick F., Ali , Syed, Westergaard, David, Yadav, Rachita, Li, Ning, Xu, Xun, Hansen, Torben, Krogh, Anders, Bolund, Lars, Sørensen, Thorkild I. A., Pedersen, Oluf, Gupta, Ramneek, Besenbacher, Søren, Børglum, Anders D., Wang, Jun, Eiberg, Hans, Kristiansen, Karsten, Brunak, Søren, Schierup, Mikkel Heide, and Izarzugaza, Jose M. G.
Subjects: 0301 basic medicine, Parents, Clinical genomics, Genotyping Techniques, Population genetics, Computational biology, Human leukocyte antigen, Biology, lcsh:Computer applications to medicine. Medical informatics, Biochemistry, Genome, Deep sequencing, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Structural Biology, HLA Antigens, Humans, HLA genotyping, Family, Allele, lcsh:QH301-705.5, Molecular Biology, Allele frequency, Whole genome sequencing, Sweden, Applied Mathematics, Histocompatibility Testing, Genomics, Computer Science Applications, Benchmarking, 030104 developmental biology, lcsh:Biology (General), 030220 oncology & carcinogenesis, NGS, lcsh:R858-859.7, DNA microarray, Prediction, Research Article
Abstract: BACKGROUND: The adaptive immune response intrinsically depends on hypervariable human leukocyte antigen (HLA) genes. Concomitantly, correct HLA phenotyping is crucial for successful donor-patient matching in organ transplantation. The cost and technical limitations of current laboratory techniques, together with advances in next-generation sequencing (NGS) methodologies, have increased the need for precise computational typing methods.RESULTS: We tested two widespread HLA typing methods using high quality full genome sequencing data from 150 individuals in 50 family trios from the Genome Denmark project. First, we computed descendant accuracies assessing the agreement in the inheritance of alleles from parents to offspring. Second, we compared the locus-specific homozygosity rates as well as the allele frequencies; and we compared those to the observed values in related populations. We provide guidelines for testing the accuracy of HLA typing methods by comparing family information, which is independent of the availability of curated alleles.CONCLUSIONS: Although current computational methods for HLA typing generally provide satisfactory results, our benchmark - using data with ultra-high sequencing depth - demonstrates the incompleteness of current reference databases, and highlights the importance of providing genomic databases addressing current sequencing standards, a problem yet to be resolved before benefiting fully from personalised medicine approaches HLA phenotyping is essential.
Published: 2018

72. Complex spatio-temporal distribution and genomic ancestry of mitochondrial DNA haplogroups in 24,216 Danes

Author: Bybjerg-Grauholm, Jonas, primary, Hagen, Christian M., additional, Gonçalves, Vanessa F., additional, Bækvad-Hansen, Marie, additional, Hansen, Christine S., additional, Hedley, Paula L., additional, Kanters, Jørgen K., additional, Nielsen, Jimmi, additional, Theisen, Michael, additional, Mors, Ole, additional, Kennedy, James, additional, Als, Thomas D., additional, Demur, Alfonso B., additional, Nordentoft, Merete, additional, Børglum, Anders, additional, Mortensen, Preben B., additional, Werge, Thomas M., additional, Hougaard, David M., additional, and Christiansen, Michael, additional
Published: 2018
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73. Schizophrenia-associated mt-DNA SNPs exhibit highly variable haplogroup affiliation and nuclear ancestry: Bi-genomic dependence raises major concerns for link to disease

Author: Hagen, Christian M., primary, Gonçalves, Vanessa F., additional, Hedley, Paula L., additional, Bybjerg-Grauholm, Jonas, additional, Bækvad-Hansen, Marie, additional, Hansen, Christine S., additional, Kanters, Jørgen K., additional, Nielsen, Jimmi, additional, Mors, Ole, additional, Demur, Alfonso B., additional, Als, Thomas D., additional, Nordentoft, Merete, additional, Børglum, Anders, additional, Mortensen, Preben B., additional, Kennedy, James, additional, Werge, Thomas M., additional, Hougaard, David M., additional, and Christiansen, Michael, additional
Published: 2018
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74. A comparison of SNP and STR loci for delineating population structure and performing individual genetic assignment

Author: Høyheim Bjørn, Als Thomas D, Lien Sigbjørn, Hansen Michael M, Glover Kevin A, and Skaala Øystein
Subjects: Genetics, QH426-470
Abstract: Abstract Background Technological advances have lead to the rapid increase in availability of single nucleotide polymorphisms (SNPs) in a range of organisms, and there is a general optimism that SNPs will become the marker of choice for a range of evolutionary applications. Here, comparisons between 300 polymorphic SNPs and 14 short tandem repeats (STRs) were conducted on a data set consisting of approximately 500 Atlantic salmon arranged in 10 samples/populations. Results Global FST ranged from 0.033-0.115 and -0.002-0.316 for the 14 STR and 300 SNP loci respectively. Global FST was similar among 28 linkage groups when averaging data from mapped SNPs. With the exception of selecting a panel of SNPs taking the locus displaying the highest global FST for each of the 28 linkage groups, which inflated estimation of genetic differentiation among the samples, inferred genetic relationships were highly similar between SNP and STR data sets and variants thereof. The best 15 SNPs (30 alleles) gave a similar level of self-assignment to the best 4 STR loci (83 alleles), however, addition of further STR loci did not lead to a notable increase assignment whereas addition of up to 100 SNP loci increased assignment. Conclusion Whilst the optimal combinations of SNPs identified in this study are linked to the samples from which they were selected, this study demonstrates that identification of highly informative SNP loci from larger panels will provide researchers with a powerful approach to delineate genetic relationships at the individual and population levels.
Published: 2010
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75. Reproductive isolation, evolutionary distinctiveness and setting conservation priorities: The case of European lake whitefish and the endangered North Sea houting (Coregonus spp.)

Author: Mensberg Karen-Lise D, Als Thomas D, Fraser Dylan J, and Hansen Michael M
Subjects: Evolution, QH359-425
Abstract: Abstract Background Adaptive radiation within fishes of the Coregonus lavaretus complex has created numerous morphs, posing significant challenges for taxonomy and conservation priorities. The highly endangered North Sea houting (C. oxyrhynchus; abbreviated NSH) has been considered a separate species from European lake whitefish (C. lavaretus; abbreviated ELW) due to morphological divergence and adaptation to oceanic salinities. However, its evolutionary and taxonomic status is controversial. We analysed microsatellite DNA polymorphism in nine populations from the Jutland Peninsula and the Baltic Sea, representing NSH (three populations, two of which are reintroduced) and ELW (six populations). The objectives were to: 1) analyse postglacial recolonization of whitefish in the region; 2) assess the evolutionary distinctiveness of NSH, and 3) apply several approaches for defining conservation units towards setting conservation priorities for NSH. Results Bayesian cluster analyses of genetic differentiation identified four major groups, corresponding to NSH and three groups of ELW (Western Jutland, Central Jutland, Baltic Sea). Estimates of historical migration rates indicated recolonization in a north-eastern direction, suggesting that all except the Baltic Sea population predominantly represent postglacial recolonization via the ancient Elbe River. Contemporary gene flow has not occurred between NSH and ELW, with a divergence time within the last 4,000 years suggested from coalescence methods. NSH showed interbreeding with ELW when brought into contact by stocking. Thus, reproductive isolation of NSH was not absolute, although possible interbreeding beyond the F1 level could not be resolved. Conclusion Fishes of the C. lavaretus complex in the Jutland Peninsula originate from the same recolonization event. NSH has evolved recently and its species status may be questioned due to incomplete reproductive isolation from ELW, but it was shown to merit consideration as an independent conservation unit. Yet, application of several approaches for defining conservation units generated mixed outcomes regarding its conservation priority. Within the total species complex, it remains one among many recently evolved unique forms. Its uniqueness and high conservation priority is more evident at a local geographical scale, where conservation efforts will also benefit populations of a number of other endangered species.
Published: 2008
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76. Analysis of 62 hybrid assembled human Y chromosomes exposes rapid structural changes and high rates of gene conversion

Author: Gonzalez-Izarzugaza, Jose Maria, Skov, Laurits, Maretty, Lasse, Jensen, Jacob Malte, Petersen, Bent, Andreas Sibbesen, Jonas, Liu, Siyang, Villesen, Palle, Belling, Kirstine González-Izarzugaza, Theil Have, Christian, Grosjean, Marie, Bork-Jensen, Jette, Grove, Jakob, Als, Thomas D., Huang, Shujia, Chang, Yuqi, Xu, Ruiqi, Ye, Weijian, Rao, Junhua, Guo, Xiaosen, Sun, Jihua, Cao, Hongzhi, Ye, Chen, van Beusekom, Johan, Espeseth, Thomas, Flindt, Esben, Friborg, Rune M., Halager, Anders E., Le Hellard, Stephanie, Hultman, Christina M., Lescai, Francesco, Li, Shengting, Lund, Ole, Løngren, Peter, Mailund, Thomas, Matey-Hernandez, María Luisa, Mors, Ole, Pedersen, Christian N. S., Sicheritz-Pontén, Thomas, Sullivan, Patrick F., Qaswar Ali Shah, Syed, Westergaard, David, Yadav, Rachita, Li, Ning, Xu, Xun, Hansen, Torben, Krogh, Anders, Bolund, Lars, Sørensen, Thorkild I. A., Pedersen, Oluf, Gupta, Ramneek, Rasmussen, Simon, Besenbacher, Søren, Børglum, Anders D., Wang, Jun, Eiberg, Hans, Kristiansen, Karsten, Brunak, Søren, and Schierup, Mikkel Heide
Subjects: 0301 basic medicine, Male, Cancer Research, Inverted repeat, Denmark, Biochemistry, Haplogroup, Fathers, 0302 clinical medicine, INDEL Mutation, Heterochromatin, MUTATION, Genetics (clinical), Phylogeny, POPULATION, Data Management, Genetics, Sex Chromosomes, Insertion Mutation, Chromosome Biology, Phylogenetic Analysis, Y Chromosomes, Nucleic acids, Phylogenetics, GENOME, ALIGNMENT, Deletion Mutation, Mutation (genetic algorithm), Research Article, EXPRESSION, Computer and Information Sciences, lcsh:QH426-470, DNA recombination, Gene Conversion, Biology, Y chromosome, Polymorphism, Single Nucleotide, SEQUENCE, Chromosomes, Nuclear Family, Evolution, Molecular, 03 medical and health sciences, Humans, Evolutionary Systematics, Gene conversion, Insertion, Indel, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Infertility, Male, Taxonomy, COPY NUMBER VARIATION, Evolutionary Biology, Chromosomes, Human, Y, Population Biology, MALE-INFERTILITY, Inverted Repeat Sequences, Biology and Life Sciences, Cell Biology, DNA, POLYMORPHISM, EVOLUTION, lcsh:Genetics, 030104 developmental biology, Evolutionary biology, Mutation, Haplogroups, 030217 neurology & neurosurgery, Population Genetics, Reference genome
Abstract: The human Y-chromosome does not recombine across its male-specific part and is therefore an excellent marker of human migrations. It also plays an important role in male fertility. However, its evolution is difficult to fully understand because of repetitive sequences, inverted repeats and the potentially large role of gene conversion. Here we perform an evolutionary analysis of 62 Y-chromosomes of Danish descent sequenced using a wide range of library insert sizes and high coverage, thus allowing large regions of these chromosomes to be well assembled. These include 17 father-son pairs, which we use to validate variation calling. Using a recent method that can integrate variants based on both mapping and de novo assembly, we genotype 10898 SNVs and 2903 indels (max length of 27241 bp) in our sample and show by father-son concordance and experimental validation that the non-recurrent SNP and indel variation on the Y chromosome tree is called very accurately. This includes variation called in a 0.9 Mb centromeric heterochromatic region, which is by far the most variable in the Y chromosome. Among the variation is also longer sequence-stretches not present in the reference genome but shared with the chimpanzee Y chromosome. We analyzed 2.7 Mb of large inverted repeats (palindromes) for variation patterns among the two palindrome arms and identified 603 mutation and 416 gene conversions events. We find clear evidence for GC-biased gene conversion in the palindromes (and a balancing AT mutation bias), but irrespective of this, also a strong bias towards gene conversion towards the ancestral state, suggesting that palindromic gene conversion may alleviate Muller’s ratchet. Finally, we also find a large number of large-scale gene duplications and deletions in the palindromic regions (at least 24) and find that such events can consist of complex combinations of simultaneous insertions and deletions of long stretches of the Y chromosome., Author summary The Y chromosome is extraordinary in many respects; it is non-recombining along most of its length, it carries many testis-expressed genes that are often found in palindromes and thus in several copies, and it is generally highly repetitive with very few unique genes. Its evolutionary process is not well understood in general because short-read mapping in such complex sequence is difficult. We combine de novo assembly and mapping to investigate evolution in more than 60% of the length of 62 Y chromosomes of Danish descent. We find that Y chromosome evolution is very dynamic even among the set of closely related Y chromosomes in Denmark with many cases of complex duplications and deletions of large regions including whole genes, clear evidence of GC-biased gene conversion in the palindromes and a tendency for gene conversion to revert mutations to their ancestral state.
Published: 2017

77. Discovery of the first genome-wide significant risk loci for ADHD

Author: Demontis, Ditte, Walters, Raymond K., Martin, Joanna, Mattheisen, Manuel, Als, Thomas D., Agerbo, Esben, Belliveau, Rich, Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Churchhouse, Claire, Dumont, Ashley, Eriksson, Nicholas, Gandal, Michael, Goldstein, Jacqueline, Grove, Jakob, Hansen, Christine S., Hauberg, Mads E., Hollegaard, Mads V., Howrigan, Daniel P., Huang, Hailiang, Maller, Julian, Martin, Alicia R., Moran, Jennifer, Pallesen, Jonatan, Palmer, Duncan S., Pedersen, Carsten B., Pedersen, Marianne G., Poterba, Timothy, Poulsen, Jesper B., Ripke, Stephan, Robinson, Elise B., Satterstrom, Kyle F., Stevens, Christine, Turley, Patrick, Won, Hyejung, Andreassen, Ole A., Burton, Christie, Boomsma, Dorret, Cormand, Bru, Dalsgaard, Søren, Franke, Barbara, Gelernter, Joel, Geschwind, Daniel, Hakonarson, Hakon, Haavik, Jan, Kranzler, Henry, Kuntsi, Jonna, Langley, Kate, Lesch, Klaus-Peter, Middeldorp, Christel, Reif, Andreas, Rohde, Luis A., Roussos, Panos, Schachar, Russell, Sklar, Pamela, Sonuga-Barke, Edmund, Sullivan, Patrick F., Thapar, Anita, Tung, Joyce, Waldman, Irwin, Nordentoft, Merete, Hougaard, David M., Werge, Thomas, Mors, Ole, Mortensen, Preben B., Daly, Mark J., Faraone, Stephen V., Børglum, Anders D., and Neale, Benjamin M.
Subjects: Genetics, 0303 health sciences, education.field_of_study, Population, Genetic variants, Biology, Genome, behavioral disciplines and activities, 3. Good health, 03 medical and health sciences, Behavior disorder, 0302 clinical medicine, Clinical diagnosis, mental disorders, Adhd symptoms, Significant risk, education, Gene, 030217 neurology & neurosurgery, 030304 developmental biology
Abstract: Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of school-age children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no individual variants have been robustly associated with ADHD. We report a genome-wide association meta-analysis of 20,183 ADHD cases and 35,191 controls that identifies variants surpassing genome-wide significance in 12 independent loci, revealing new and important information on the underlying biology of ADHD. Associations are enriched in evolutionarily constrained genomic regions and loss-of-function intolerant genes, as well as around brain-expressed regulatory marks. These findings, based on clinical interviews and/or medical records are supported by additional analyses of a self-reported ADHD sample and a study of quantitative measures of ADHD symptoms in the population. Meta-analyzing these data with our primary scan yielded a total of 16 genome-wide significant loci. The results support the hypothesis that clinical diagnosis of ADHD is an extreme expression of one or more continuous heritable traits.
Published: 2017
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78. Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Author: Ruderfer, Douglas M., primary, Ripke, Stephan, additional, McQuillin, Andrew, additional, Boocock, James, additional, Stahl, Eli A., additional, Pavlides, Jennifer M. Whitehead, additional, Mullins, Niamh, additional, Charney, Alexander W., additional, Ori, Anil P.S., additional, Loohuis, Loes M. Olde, additional, Domenici, Enrico, additional, Di Florio, Arianna, additional, Papiol, Sergi, additional, Kalman, Janos L., additional, Trubetskoy, Vassily, additional, Adolfsson, Rolf, additional, Agartz, Ingrid, additional, Agerbo, Esben, additional, Akil, Huda, additional, Albani, Diego, additional, Albus, Margot, additional, Alda, Martin, additional, Alexander, Madeline, additional, Alliey-Rodriguez, Ney, additional, Als, Thomas D., additional, Amin, Farooq, additional, Anjorin, Adebayo, additional, Arranz, Maria J., additional, Awasthi, Swapnil, additional, Bacanu, Silviu A., additional, Badner, Judith A., additional, Baekvad-Hansen, Marie, additional, Bakker, Steven, additional, Band, Gavin, additional, Barchas, Jack D., additional, Barroso, Ines, additional, Bass, Nicholas, additional, Bauer, Michael, additional, Baune, Bernhard T., additional, Begemann, Martin, additional, Bellenguez, Celine, additional, Belliveau, Richard A., additional, Bellivier, Frank, additional, Bender, Stephan, additional, Bene, Judit, additional, Bergen, Sarah E., additional, Berrettini, Wade H., additional, Bevilacqua, Elizabeth, additional, Biernacka, Joanna M., additional, Bigdeli, Tim B., additional, Black, Donald W., additional, Blackburn, Hannah, additional, Blackwell, Jenefer M., additional, Blackwood, Douglas H.R., additional, Pedersen, Carsten Bocker, additional, Boehnke, Michael, additional, Boks, Marco, additional, Borglum, Anders D., additional, Bramon, Elvira, additional, Breen, Gerome, additional, Brown, Matthew A., additional, Bruggeman, Richard, additional, Buccola, Nancy G., additional, Buckner, Randy L., additional, Budde, Monika, additional, Bulik-Sullivan, Brendan, additional, Bumpstead, Suzannah J., additional, Bunney, William, additional, Burmeister, Margit, additional, Buxbaum, Joseph D., additional, Bybjerg-Grauholm, Jonas, additional, Byerley, William, additional, Cahn, Wiepke, additional, Cai, Guiqing, additional, Cairns, Murray J., additional, Campion, Dominique, additional, Cantor, Rita M., additional, Carr, Vaughan J., additional, Carrera, Noa, additional, Casas, Juan P., additional, Casas, Miquel, additional, Catts, Stanley V., additional, Cervantes, Pablo, additional, Chambert, Kimberley D., additional, Chan, Raymond C.K., additional, Chen, Eric Y.H., additional, Chen, Ronald Y.L., additional, Cheng, Wei, additional, Cheung, Eric F.C., additional, Chong, Siow Ann, additional, Clarke, Toni-Kim, additional, Cloninger, C. Robert, additional, Cohen, David, additional, Cohen, Nadine, additional, Coleman, Jonathan R.I., additional, Collier, David A., additional, Cormican, Paul, additional, Coryell, William, additional, Craddock, Nicholas, additional, Craig, David W., additional, Crespo-Facorro, Benedicto, additional, Crowley, James J., additional, Cruceanu, Cristiana, additional, Curtis, David, additional, Czerski, Piotr M., additional, Dale, Anders M., additional, Daly, Mark J., additional, Dannlowski, Udo, additional, Darvasi, Ariel, additional, Davidson, Michael, additional, Davis, Kenneth L., additional, de Leeuw, Christiaan A., additional, Degenhardt, Franziska, additional, Del Favero, Jurgen, additional, DeLisi, Lynn E., additional, Deloukas, Panos, additional, Demontis, Ditte, additional, DePaulo, J. Raymond, additional, di Forti, Marta, additional, Dikeos, Dimitris, additional, Dinan, Timothy, additional, Djurovic, Srdjan, additional, Dobbyn, Amanda L., additional, Donnelly, Peter, additional, Donohoe, Gary, additional, Drapeau, Elodie, additional, Dronov, Serge, additional, Duan, Jubao, additional, Dudbridge, Frank, additional, Duncanson, Audrey, additional, Edenberg, Howard, additional, Edkins, Sarah, additional, Ehrenreich, Hannelore, additional, Eichhammer, Peter, additional, Elvsashagen, Torbjorn, additional, Eriksson, Johan, additional, Escott-Price, Valentina, additional, Esko, Tonu, additional, Essioux, Laurent, additional, Etain, Bruno, additional, Fan, Chun Chieh, additional, Farh, Kai-How, additional, Farrell, Martilias S., additional, Flickinger, Matthew, additional, Foroud, Tatiana M., additional, Forty, Liz, additional, Frank, Josef, additional, Franke, Lude, additional, Fraser, Christine, additional, Freedman, Robert, additional, Freeman, Colin, additional, Freimer, Nelson B., additional, Friedman, Joseph I., additional, Fromer, Menachem, additional, Frye, Mark A., additional, Fullerton, Janice M., additional, Gade, Katrin, additional, Garnham, Julie, additional, Gaspar, Helena A., additional, Gejman, Pablo V., additional, Genovese, Giulio, additional, Georgieva, Lyudmila, additional, Giambartolomei, Claudia, additional, Giannoulatou, Eleni, additional, Giegling, Ina, additional, Gill, Michael, additional, Gillman, Matthew, additional, Pedersen, Marianne Giortz, additional, Giusti-Rodriguez, Paola, additional, Godard, Stephanie, additional, Goes, Fernando, additional, Goldstein, Jacqueline I., additional, Gopal, Srihari, additional, Gordon, Scott D., additional, Gordon-Smith, Katherine, additional, Gratten, Jacob, additional, Gray, Emma, additional, Green, Elaine K., additional, Green, Melissa J., additional, Greenwood, Tiffany A., additional, Grigoroiu-Serbanescu, Maria, additional, Grove, Jakob, additional, Guan, Weihua, additional, Gurling, Hugh, additional, Parra, Jose Guzman, additional, Gwilliam, Rhian, additional, de Haan, Lieuwe, additional, Hall, Jeremy, additional, Hall, Mei-Hua, additional, Hammer, Christian, additional, Hammond, Naomi, additional, Hamshere, Marian L., additional, Hansen, Mark, additional, Hansen, Thomas, additional, Haroutunian, Vahram, additional, Hartmann, Annette M., additional, Hauser, Joanna, additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, Hellenthal, Garrett, additional, Henskens, Frans A., additional, Herms, Stefan, additional, Hipolito, Maria, additional, Hirschhorn, Joel N., additional, Hoffmann, Per, additional, Hollegaard, Mads V., additional, Hougaard, David M., additional, Huang, Hailiang, additional, Huckins, Laura, additional, Hultman, Christina M., additional, Hunt, Sarah E., additional, Ikeda, Masashi, additional, Iwata, Nakao, additional, Iyegbe, Conrad, additional, Jablensky, Assen V., additional, Jamain, Stephane, additional, Jankowski, Janusz, additional, Jayakumar, Alagurevathi, additional, Joa, Inge, additional, Jones, Ian, additional, Jones, Lisa A., additional, Jonsson, Erik G., additional, Julia, Antonio, additional, Jureus, Anders, additional, Kahler, Anna K., additional, Kahn, Rene S., additional, Kalaydjieva, Luba, additional, Kandaswamy, Radhika, additional, Karachanak-Yankova, Sena, additional, Karjalainen, Juha, additional, Karlsson, Robert, additional, Kavanagh, David, additional, Keller, Matthew C., additional, Kelly, Brian J., additional, Kelsoe, John, additional, Kennedy, James L., additional, Khrunin, Andrey, additional, Kim, Yunjung, additional, Kirov, George, additional, Kittel-Schneider, Sarah, additional, Klovins, Janis, additional, Knight, Jo, additional, Knott, Sarah V., additional, Knowles, James A., additional, Kogevinas, Manolis, additional, Konte, Bettina, additional, Kravariti, Eugenia, additional, Kucinskas, Vaidutis, additional, Kucinskiene, Zita Ausrele, additional, Kupka, Ralph, additional, Kuzelova-Ptackova, Hana, additional, Landen, Mikael, additional, Langford, Cordelia, additional, Laurent, Claudine, additional, Lawrence, Jacob, additional, Lawrie, Stephen, additional, Lawson, William B., additional, Leber, Markus, additional, Leboyer, Marion, additional, Lee, Phil H., additional, Keong, Jimmy Lee Chee, additional, Legge, Sophie E., additional, Lencz, Todd, additional, Lerer, Bernard, additional, Levinson, Douglas F., additional, Levy, Shawn E., additional, Lewis, Cathryn M., additional, Li, Jun Z., additional, Li, Miaoxin, additional, Li, Qingqin S., additional, Li, Tao, additional, Liang, Kung-Yee, additional, Liddle, Jennifer, additional, Lieberman, Jeffrey, additional, Limborska, Svetlana, additional, Lin, Kuang, additional, Linszen, Don H., additional, Lissowska, Jolanta, additional, Liu, Chunyu, additional, Liu, Jianjun, additional, Lonnqvist, Jouko, additional, Loughland, Carmel M., additional, Lubinski, Jan, additional, Lucae, Susanne, additional, Macek, Milan, additional, MacIntyre, Donald J., additional, Magnusson, Patrik K.E., additional, Maher, Brion S., additional, Mahon, Pamela B., additional, Maier, Wolfgang, additional, Malhotra, Anil K., additional, Mallet, Jacques, additional, Malt, Ulrik F., additional, Markus, Hugh S., additional, Marsal, Sara, additional, Martin, Nicholas G., additional, Mata, Ignacio, additional, Mathew, Christopher G., additional, Mattheisen, Manuel, additional, Mattingsdal, Morten, additional, Mayoral, Fermin, additional, McCann, Owen T., additional, McCarley, Robert W., additional, McCarroll, Steven A., additional, McCarthy, Mark I., additional, McDonald, Colm, additional, McElroy, Susan L., additional, McGuffin, Peter, additional, McInnis, Melvin G., additional, McIntosh, Andrew M., additional, McKay, James D., additional, McMahon, Francis J., additional, Medeiros, Helena, additional, Medland, Sarah E., additional, Meier, Sandra, additional, Meijer, Carin J., additional, Melegh, Bela, additional, Melle, Ingrid, additional, Meng, Fan, additional, Mesholam-Gately, Raquelle I., additional, Metspalu, Andres, additional, Michie, Patricia T., additional, Milani, Lili, additional, Milanova, Vihra, additional, Mitchell, Philip B., additional, Mokrab, Younes, additional, Montgomery, Grant W., additional, Moran, Jennifer L., additional, Morken, Gunnar, additional, Morris, Derek W., additional, Mors, Ole, additional, Mortensen, Preben B., additional, Mowry, Bryan J., additional, Mühleisen, Thomas W., additional, Müller-Myhsok, Bertram, additional, Murphy, Kieran C., additional, Murray, Robin M., additional, Myers, Richard M., additional, Myin-Germeys, Inez, additional, Neale, Benjamin M., additional, Nelis, Mari, additional, Nenadic, Igor, additional, Nertney, Deborah A., additional, Nestadt, Gerald, additional, Nicodemus, Kristin K., additional, Nievergelt, Caroline M., additional, Nikitina-Zake, Liene, additional, Nimgaonkar, Vishwajit, additional, Nisenbaum, Laura, additional, Nordentoft, Merete, additional, Nordin, Annelie, additional, Nöthen, Markus M., additional, Nwulia, Evaristus A., additional, O’Callaghan, Eadbhard, additional, O’Donovan, Claire, additional, O’Dushlaine, Colm, additional, O’Neill, F. Anthony, additional, Oedegaard, Ketil J., additional, Oh, Sang-Yun, additional, Olincy, Ann, additional, Olsen, Line, additional, Oruc, Lilijana, additional, Van Os, Jim, additional, Owen, Michael J., additional, Paciga, Sara A., additional, Palmer, Colin N.A., additional, Palotie, Aarno, additional, Pantelis, Christos, additional, Papadimitriou, George N., additional, Parkhomenko, Elena, additional, Pato, Carlos, additional, Pato, Michele T., additional, Paunio, Tiina, additional, Pearson, Richard, additional, Perkins, Diana O., additional, Perlis, Roy H., additional, Perry, Amy, additional, Pers, Tune H., additional, Petryshen, Tracey L., additional, Pfennig, Andrea, additional, Picchioni, Marco, additional, Pietilainen, Olli, additional, Pimm, Jonathan, additional, Pirinen, Matti, additional, Plomin, Robert, additional, Pocklington, Andrew J., additional, Posthuma, Danielle, additional, Potash, James B., additional, Potter, Simon C., additional, Powell, John, additional, Price, Alkes, additional, Pulver, Ann E., additional, Purcell, Shaun M., additional, Quested, Digby, additional, Ramos-Quiroga, Josep Antoni, additional, Rasmussen, Henrik B., additional, Rautanen, Anna, additional, Ravindrarajah, Radhi, additional, Regeer, Eline J., additional, Reichenberg, Abraham, additional, Reif, Andreas, additional, Reimers, Mark A., additional, Ribases, Marta, additional, Rice, John P., additional, Richards, Alexander L., additional, Ricketts, Michelle, additional, Riley, Brien P., additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Roffman, Joshua L., additional, Rouleau, Guy A., additional, Roussos, Panos, additional, Rujescu, Dan, additional, Salomaa, Veikko, additional, Sanchez-Mora, Cristina, additional, Sanders, Alan R., additional, Sawcer, Stephen J., additional, Schall, Ulrich, additional, Schatzberg, Alan F., additional, Scheftner, William A., additional, Schofield, Peter R., additional, Schork, Nicholas J., additional, Schwab, Sibylle G., additional, Scolnick, Edward M., additional, Scott, Laura J., additional, Scott, Rodney J., additional, Seidman, Larry J., additional, Serretti, Alessandro, additional, Sham, Pak C., additional, Weickert, Cynthia Shannon, additional, Shehktman, Tatyana, additional, Shi, Jianxin, additional, Shilling, Paul D., additional, Sigurdsson, Engilbert, additional, Silverman, Jeremy M., additional, Sim, Kang, additional, Slaney, Claire, additional, Slominsky, Petr, additional, Smeland, Olav B., additional, Smoller, Jordan W., additional, So, Hon-Cheong, additional, Sobell, Janet L., additional, Soderman, Erik, additional, Hansen, Christine Soholm, additional, Spencer, Chris C.A., additional, Spijker, Anne T., additional, St Clair, David, additional, Stefansson, Hreinn, additional, Stefansson, Kari, additional, Steinberg, Stacy, additional, Stogmann, Elisabeth, additional, Stordal, Eystein, additional, Strange, Amy, additional, Straub, Richard E., additional, Strauss, John S., additional, Streit, Fabian, additional, Strengman, Eric, additional, Strohmaier, Jana, additional, Stroup, T. Scott, additional, Su, Zhan, additional, Subramaniam, Mythily, additional, Suvisaari, Jaana, additional, Svrakic, Dragan M., additional, Szatkiewicz, Jin P., additional, Szelinger, Szabolcs, additional, Tashakkori-Ghanbaria, Avazeh, additional, Thirumalai, Srinivas, additional, Thompson, Robert C., additional, Thorgeirsson, Thorgeir E., additional, Toncheva, Draga, additional, Tooney, Paul A., additional, Tosato, Sarah, additional, Toulopoulou, Timothea, additional, Trembath, Richard C., additional, Treutlein, Jens, additional, Turecki, Gustavo, additional, Vaaler, Arne E., additional, Vedder, Helmut, additional, Vieta, Eduard, additional, Vincent, John, additional, Visscher, Peter M., additional, Viswanathan, Ananth C., additional, Vukcevic, Damjan, additional, Waddington, John, additional, Waller, Matthew, additional, Walsh, Dermot, additional, Walshe, Muriel, additional, Walters, James T.R., additional, Wang, Dai, additional, Wang, Qiang, additional, Wang, Weiqing, additional, Wang, Yunpeng, additional, Watson, Stanley J., additional, Webb, Bradley T., additional, Weickert, Thomas W., additional, Weinberger, Daniel R., additional, Weisbrod, Matthias, additional, Weiser, Mark, additional, Werge, Thomas, additional, Weston, Paul, additional, Whittaker, Pamela, additional, Widaa, Sara, additional, Wiersma, Durk, additional, Wildenauer, Dieter B., additional, Williams, Nigel M., additional, Williams, Stephanie, additional, Witt, Stephanie H., additional, Wolen, Aaron R., additional, Wong, Emily H.M., additional, Wood, Nicholas W., additional, Wormley, Brandon K., additional, Wu, Jing Qin, additional, Xi, Simon, additional, Xu, Wei, additional, Young, Allan H., additional, Zai, Clement C., additional, Zandi, Peter, additional, Zhang, Peng, additional, Zheng, Xuebin, additional, Zimprich, Fritz, additional, Zollner, Sebastian, additional, Corvin, Aiden, additional, Fanous, Ayman H., additional, Cichon, Sven, additional, Rietschel, Marcella, additional, Gershon, Elliot S., additional, Schulze, Thomas G., additional, Cuellar-Barboza, Alfredo B., additional, Forstner, Andreas J., additional, Holmans, Peter A., additional, Nurnberger, John I., additional, Andreassen, Ole A., additional, Lee, S. Hong, additional, O’Donovan, Michael C., additional, Sullivan, Patrick F., additional, Ophoff, Roel A., additional, Wray, Naomi R., additional, Sklar, Pamela, additional, and Kendler, Kenneth S., additional
Published: 2018
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79. Genome-wide association study implicates CHRNA2 in cannabis use disorder

Author: Demontis, Ditte, primary, Rajagopal, Veera Manikandan, additional, Als, Thomas D., additional, Grove, Jakob, additional, Pallesen, Jonatan, additional, Hjorthøj, Carsten, additional, Qvist, Per, additional, Christensen, Jane Hvarregaard, additional, Bybjerg-Grauholm, Jonas, additional, Bækvad-Hansen, Marie, additional, Huckins, Laura M., additional, Stahl, Eli A., additional, Timmermann, Allan, additional, Agerbo, Esben, additional, Hougaard, David M., additional, Werge, Thomas, additional, Mors, Ole, additional, Mortensen, Preben Bo, additional, Nordentoft, Merete, additional, Daly, Mark, additional, Nyegaard, Mette, additional, and Børglum, Anders D., additional
Published: 2017
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80. Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder

Author: Stahl, Eli A, primary, Breen, Gerome, additional, Forstner, Andreas J, additional, McQuillin, Andrew, additional, Ripke, Stephan, additional, Trubetskoy, Vassily, additional, Mattheisen, Manuel, additional, Wang, Yunpeng, additional, Coleman, Jonathan R I, additional, Gaspar, Héléna A, additional, de Leeuw, Christiaan A, additional, Steinberg, Stacy, additional, Whitehead Pavlides, Jennifer M, additional, Trzaskowski, Maciej, additional, Pers, Tune H, additional, Holmans, Peter A, additional, Abbott, Liam, additional, Agerbo, Esben, additional, Akil, Huda, additional, Albani, Diego, additional, Alliey-Rodriguez, Ney, additional, Als, Thomas D, additional, Anjorin, Adebayo, additional, Antilla, Verneri, additional, Awasthi, Swapnil, additional, Badner, Judith A, additional, Bækvad-Hansen, Marie, additional, Barchas, Jack D, additional, Bass, Nicholas, additional, Bauer, Michael, additional, Belliveau, Richard, additional, Bergen, Sarah E, additional, Bøcker Pedersen, Carsten, additional, Bøen, Erlend, additional, Boks, Marco, additional, Boocock, James, additional, Budde, Monika, additional, Bunney, William, additional, Burmeister, Margit, additional, Bybjerg-Grauholm, Jonas, additional, Byerley, William, additional, Casas, Miquel, additional, Cerrato, Felecia, additional, Cervantes, Pablo, additional, Chambert, Kimberly, additional, Charney, Alexander W, additional, Chen, Danfeng, additional, Churchhouse, Claire, additional, Clarke, Toni-Kim, additional, Coryell, William, additional, Craig, David W, additional, Cruceanu, Cristiana, additional, Curtis, David, additional, Czerski, Piotr M, additional, Dale, Anders M, additional, de Jong, Simone, additional, Degenhardt, Franziska, additional, Del-Favero, Jurgen, additional, DePaulo, J Raymond, additional, Djurovic, Srdjan, additional, Dobbyn, Amanda L, additional, Dumont, Ashley, additional, Elvsåshagen, Torbjørn, additional, Escott-Price, Valentina, additional, Fan, Chun Chieh, additional, Fischer, Sascha B, additional, Flickinger, Matthew, additional, Foroud, Tatiana M, additional, Forty, Liz, additional, Frank, Josef, additional, Fraser, Christine, additional, Freimer, Nelson B, additional, Frisén, Louise, additional, Gade, Katrin, additional, Gage, Diane, additional, Garnham, Julie, additional, Giambartolomei, Claudia, additional, Giørtz Pedersen, Marianne, additional, Goldstein, Jaqueline, additional, Gordon, Scott D, additional, Gordon-Smith, Katherine, additional, Green, Elaine K, additional, Green, Melissa J, additional, Greenwood, Tiffany A, additional, Grove, Jakob, additional, Guan, Weihua, additional, Parra, JoséGuzman, additional, Hamshere, Marian L, additional, Hautzinger, Martin, additional, Heilbronner, Urs, additional, Herms, Stefan, additional, Hipolito, Maria, additional, Hoffmann, Per, additional, Holland, Dominic, additional, Huckins, Laura, additional, Jamain, Stéphane, additional, Johnson, Jessica S, additional, Juréus, Anders, additional, Kandaswamy, Radhika, additional, Karlsson, Robert, additional, Kennedy, James L, additional, Kittel-Schneider, Sarah, additional, Knott, Sarah V, additional, Knowles, James A, additional, Kogevinas, Manolis, additional, Koller, Anna C, additional, Kupka, Ralph, additional, Lavebratt, Catharina, additional, Lawrence, Jacob, additional, Lawson, William B, additional, Leber, Markus, additional, Lee, Phil H, additional, Levy, Shawn E, additional, Li, Jun Z, additional, Liu, Chunyu, additional, Lucae, Susanne, additional, Maaser, Anna, additional, MacIntyre, Donald J, additional, Mahon, Pamela B, additional, Maier, Wolfgang, additional, Martinsson, Lina, additional, McCarroll, Steve, additional, McGuffin, Peter, additional, McInnis, Melvin G, additional, McKay, James D, additional, Medeiros, Helena, additional, Medland, Sarah E, additional, Meng, Fan, additional, Milani, Lili, additional, Montgomery, Grant W, additional, Morris, Derek W, additional, Mühleisen, Thomas W, additional, Mullins, Niamh, additional, Nguyen, Hoang, additional, Nievergelt, Caroline M, additional, Adolfsson, Annelie Nordin, additional, Nwulia, Evaristus A, additional, O’Donovan, Claire, additional, Olde Loohuis, Loes M, additional, Ori, Anil P S, additional, Oruc, Lilijana, additional, Ösby, Urban, additional, Perlis, Roy H, additional, Perry, Amy, additional, Pfennig, Andrea, additional, Potash, James B, additional, Purcell, Shaun M, additional, Regeer, Eline J, additional, Reif, Andreas, additional, Reinbold, Céline S, additional, Rice, John P, additional, Rivas, Fabio, additional, Rivera, Margarita, additional, Roussos, Panos, additional, Ruderfer, Douglas M, additional, Ryu, Euijung, additional, Sánchez-Mora, Cristina, additional, Schatzberg, Alan F, additional, Scheftner, William A, additional, Schork, Nicholas J, additional, Weickert, Cynthia Shannon, additional, Shehktman, Tatyana, additional, Shilling, Paul D, additional, Sigurdsson, Engilbert, additional, Slaney, Claire, additional, Smeland, Olav B, additional, Sobell, Janet L, additional, Søholm Hansen, Christine, additional, Spijker, Anne T, additional, St Clair, David, additional, Steffens, Michael, additional, Strauss, John S, additional, Streit, Fabian, additional, Strohmaier, Jana, additional, Szelinger, Szabolcs, additional, Thompson, Robert C, additional, Thorgeirsson, Thorgeir E, additional, Treutlein, Jens, additional, Vedder, Helmut, additional, Wang, Weiqing, additional, Watson, Stanley J, additional, Weickert, Thomas W, additional, Witt, Stephanie H, additional, Xi, Simon, additional, Xu, Wei, additional, Young, Allan H, additional, Zandi, Peter, additional, Zhang, Peng, additional, Zollner, Sebastian, additional, Adolfsson, Rolf, additional, Agartz, Ingrid, additional, Alda, Martin, additional, Backlund, Lena, additional, Baune, Bernhard T, additional, Bellivier, Frank, additional, Berrettini, Wade H, additional, Biernacka, Joanna M, additional, Blackwood, Douglas H R, additional, Boehnke, Michael, additional, Børglum, Anders D, additional, Corvin, Aiden, additional, Craddock, Nicholas, additional, Daly, Mark J, additional, Dannlowski, Udo, additional, Esko, Tõnu, additional, Etain, Bruno, additional, Frye, Mark, additional, Fullerton, Janice M, additional, Gershon, Elliot S, additional, Gill, Michael, additional, Goes, Fernando, additional, Grigoroiu-Serbanescu, Maria, additional, Hauser, Joanna, additional, Hougaard, David M, additional, Hultman, Christina M, additional, Jones, Ian, additional, Jones, Lisa A, additional, Kahn, RenéS, additional, Kirov, George, additional, Landén, Mikael, additional, Leboyer, Marion, additional, Lewis, Cathryn M, additional, Li, Qingqin S, additional, Lissowska, Jolanta, additional, Martin, Nicholas G, additional, Mayoral, Fermin, additional, McElroy, Susan L, additional, McIntosh, Andrew M, additional, McMahon, Francis J, additional, Melle, Ingrid, additional, Metspalu, Andres, additional, Mitchell, Philip B, additional, Morken, Gunnar, additional, Mors, Ole, additional, Mortensen, Preben Bo, additional, Müller-Myhsok, Bertram, additional, Myers, Richard M, additional, Neale, Benjamin M, additional, Nimgaonkar, Vishwajit, additional, Nordentoft, Merete, additional, Nöthen, Markus M, additional, O’Donovan, Michael C, additional, Oedegaard, Ketil J, additional, Owen, Michael J, additional, Paciga, Sara A, additional, Pato, Carlos, additional, Pato, Michele T, additional, Posthuma, Danielle, additional, Ramos-Quiroga, Josep Antoni, additional, Ribasés, Marta, additional, Rietschel, Marcella, additional, Rouleau, Guy A, additional, Schalling, Martin, additional, Schofield, Peter R, additional, Schulze, Thomas G, additional, Serretti, Alessandro, additional, Smoller, Jordan W, additional, Stefansson, Hreinn, additional, Stefansson, Kari, additional, Stordal, Eystein, additional, Sullivan, Patrick F, additional, Turecki, Gustavo, additional, Vaaler, Arne E, additional, Vieta, Eduard, additional, Vincent, John B, additional, Werge, Thomas, additional, Nurnberger, John I, additional, Wray, Naomi R, additional, Di Florio, Arianna, additional, Edenberg, Howard J, additional, Cichon, Sven, additional, Ophoff, Roel A, additional, Scott, Laura J, additional, Andreassen, Ole A, additional, Kelsoe, John, additional, and Sklar, Pamela, additional
Published: 2017
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81. Mitochondrial DNA SNPs associated with Schizophrenia exhibit Highly Variable Inter-allelic Haplogroup Affiliation and Nuclear Genogeographic Affinity: Bi-Genomic Linkage Disequilibrium raises Major Concerns for Link to Disease

Author: Hagen, Christian M, primary, Gonçalves, Vanessa F, additional, Hedley, Paula L, additional, Bybjerg-Grauholm, Jonas, additional, Bækvad-Hansen, Marie, additional, Hansen, Christine S, additional, Kanters, Jørgen K, additional, Nielsen, Jimmi, additional, Mors, Ole, additional, Demur, Alfonso B, additional, Als, Thomas D, additional, Nordentoft, Merete, additional, Børglum, Anders, additional, Mortensen, Preben Bo, additional, Kennedy, James, additional, Werge, Thomas M, additional, Hougaard, David M, additional, and Christiansen, Michael, additional
Published: 2017
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82. Complex spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes

Author: Bybjerg-Grauholm, Jonas, primary, Hagen, Christian, additional, Goncalves, Vanessa F, additional, Baekvad-Hansen, Marie, additional, Hansen, Christine Soeholm, additional, Hedley, Paula L, additional, Kanters, Jorgen K, additional, Nielsen, Jimmi, additional, Theisen, Michael, additional, Mors, Ole, additional, Kennedy, James, additional, Als, Thomas D, additional, Demur, Alfonso Buil, additional, Werge, Thomas, additional, Nordentoft, Merete, additional, Borglum, Anders, additional, Mortensen, Preben Bo, additional, Hougaard, David, additional, and Christiansen, Michael, additional
Published: 2017
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83. The iPSYCH2012 case-cohort sample: New directions for unravelling genetic and environmental architectures of severe mental disorders

Author: Pedersen, Carsten Boecker, primary, Bybjerg-Grauholm, Jonas, additional, Pedersen, Marianne Gioertz, additional, Grove, Jakob, additional, Agerbo, Esben, additional, Baekvad-Hansen, Marie, additional, Poulsen, Jesper Buchhave, additional, Hansen, Christine Soeholm, additional, McGrath, John, additional, Als, Thomas D., additional, Goldstein, Jacqueline, additional, Neale, Benjamin, additional, Daly, Mark, additional, Hougaard, David, additional, Mors, Ole, additional, Nordentoft, Merete, additional, Boerglum, Anders, additional, Werge, Thomas, additional, and Mortensen, Preben Bo, additional
Published: 2017
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84. Nationwide Genomic Study in Denmark Reveals Remarkable Population Homogeneity

Author: Athanasiadis, Georgios, primary, Cheng, Jade Y, additional, Vilhjálmsson, Bjarni J, additional, Jørgensen, Frank G, additional, Als, Thomas D, additional, Le Hellard, Stephanie, additional, Espeseth, Thomas, additional, Sullivan, Patrick F, additional, Hultman, Christina M, additional, Kjærgaard, Peter C, additional, Schierup, Mikkel H, additional, and Mailund, Thomas, additional
Published: 2016
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85. 64GENOME-WIDE ASSOCIATION STUDY OF SCHOOL GRADES INFORMS COGNITIVE GENETIC ARCHITECTURE OF SIX MAJOR PSYCHIATRIC DISORDERS

Author: Rajagopal, Veera, Ganna, Andrea, Coleman, Jonathan R.I., Agerbo, Esben, Grove, Jakob, Als, Thomas D., Horsdal, Henriette T., Petersen, Liselotte, iPSYCH-Broad Consortium, Breen, Gerome, Børglum, Anders, and Demontis, Ditte
Published: 2019
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86. Differential timing of gene expression regulation between leptocephali of the two Anguilla eel species in the Sargasso Sea

Author: Bernatchez, Louis, St-Cyr, Jerome, Normandeau, Eric, Maes, Gregory, Als, Thomas D, Kalujnaia, Svetlana, Cramb, Gordon, Castonguay, Martin, Hansen, Michael M, NERC, and University of St Andrews. School of Medicine
Subjects: QL, speciation, reproductive isolation, Speciation, QH Natural history, QH, Microarray, QL Zoology, Anguilla, Transcriptome, microarray, Reproductive isolation, Original Research
Abstract: The unique life-history characteristics of North Atlantic catadromous eels have long intrigued evolutionary biologists, especially with respect to mechanisms that could explain their persistence as two ecologically very similar but reproductively and geographically distinct species. Differential developmental schedules during young larval stages have commonly been hypothesized to represent such a key mechanism. We performed a comparative analysis of gene expression by means of microarray experiments with American and European eel leptocephali collected in the Sargasso Sea in order to test the alternative hypotheses of (1) differential timing of gene expression regulation during early development versus (2) species-specific differences in expression of particular genes. Our results provide much stronger support for the former hypothesis since no gene showed consistent significant differences in expression levels between the two species. In contrast, 146 genes showed differential timings of expression between species, although the observed expression level differences between the species were generally small. Consequently, species-specific gene expression regulation seems to play a minor role in species differentiation. Overall, these results show that the basis of the early developmental divergence between the American and European eel is probably influenced by differences in the timing of gene expression regulation for genes involved in a large array of biological functions. ispartof: Ecology and Evolution vol:1 issue:4 pages:459-467 ispartof: location:England status: published
Published: 2011

87. Association mellem markører på kromosom 19p13 og panikangst

Author: Noomi Gregersen, Henriette Buttenschøn, Dahl, Hans A., Leslie Foldager, Als, Thomas D., August Wang, Sofus Joensen, Ann Suhl Kristensen, David Woldbye, Pernille Koefoed, Kruse, Torben A., Anders Børglum, and Ole Mors
Published: 2010

88. Do North Atlantic eels show parallel patterns of spatially varying selection?

Author: Ulrik, Malene G, primary, Pujolar, José Martín, additional, Ferchaud, Anne-Laure, additional, Jacobsen, Magnus W, additional, Als, Thomas D, additional, Gagnaire, Pierre Alexandre, additional, Frydenberg, Jane, additional, Bøcher, Peder K, additional, Jónsson, Bjarni, additional, Bernatchez, Louis, additional, and Hansen, Michael M, additional
Published: 2014
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89. Microevolution in time and space: SNP analysis of historical DNA reveals dynamic signatures of selection in Atlantic cod

Author: Therkildsen, Nina O., primary, Hemmer-Hansen, Jakob, additional, Als, Thomas D., additional, Swain, Douglas P., additional, Morgan, M. Joanne, additional, Trippel, Edward A., additional, Palumbi, Stephen R., additional, Meldrup, Dorte, additional, and Nielsen, Einar E., additional
Published: 2013
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90. Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function.

Author: Xiong-Jian Luo, Mattheisen, Manuel, Ming Li, Liang Huang, Rietschel, Marcella, Børglum, Anders D., Als, Thomas D., van den Oord, Edwin J., Aberg, Karolina A., Mors, Ole, Mortensen, Preben Bo, Zhenwu Luo, Degenhardt, Franziska, Cichon, Sven, Schulze, Thomas G., Nöthen, Markus M., Bing Su, Zhongming Zhao, Lin Gan, and Yao, Yong-Gang
Subjects: BRAIN anatomy, LUNG physiology, GENETICS of schizophrenia, SCHIZOPHRENIA risk factors, GENE expression, GENETIC techniques, PROBABILITY theory, RESEARCH funding, DEMOGRAPHIC characteristics, DATA analysis software
Published: 2015
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91. Differential timing of gene expression regulation between leptocephali of the two Anguilla eel species in the Sargasso Sea

Author: Bernatchez, Louis, primary, St-Cyr, Jérôme, additional, Normandeau, Eric, additional, Maes, Gregory E., additional, Als, Thomas D., additional, Kalujnaia, Svetlana, additional, Cramb, Gordon, additional, Castonguay, Martin, additional, and Hansen, Michael M., additional
Published: 2011
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92. A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene

Author: Gregersen, Noomi, primary, Dahl, Hans A, additional, Buttenschøn, Henriette N, additional, Nyegaard, Mette, additional, Hedemand, Anne, additional, Als, Thomas D, additional, Wang, August G, additional, Joensen, Sofus, additional, Woldbye, David PD, additional, Koefoed, Pernille, additional, Kristensen, Ann S, additional, Kruse, Torben A, additional, Børglum, Anders D, additional, and Mors, Ole, additional
Published: 2011
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93. All roads lead to home: panmixia of European eel in the Sargasso Sea

Author: ALS, THOMAS D., primary, HANSEN, MICHAEL M., additional, MAES, GREGORY E., additional, CASTONGUAY, MARTIN, additional, RIEMANN, LASSE, additional, AARESTRUP, KIM, additional, MUNK, PETER, additional, SPARHOLT, HENRIK, additional, HANEL, REINHOLD, additional, and BERNATCHEZ, LOUIS, additional
Published: 2011
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94. Qualitative assessment of the diet of European eel larvae in the Sargasso Sea resolved by DNA barcoding

Author: Riemann, Lasse, primary, Alfredsson, Hanna, additional, Hansen, Michael M., additional, Als, Thomas D., additional, Nielsen, Torkel G., additional, Munk, Peter, additional, Aarestrup, Kim, additional, Maes, Gregory E., additional, Sparholt, Henrik, additional, Petersen, Michael I., additional, Bachler, Mirjam, additional, and Castonguay, Martin, additional
Published: 2010
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95. Support for a bipolar affective disorder susceptibility locus on chromosome 12q24.3

Author: Buttenchøn, Henriette Nørmølle, primary, Foldager, Leslie, additional, Flint, Tracey J., additional, Olsen, Inger Marie L., additional, Deleuran, Thomas, additional, Nyegaard, Mette, additional, Hansen, Mette M., additional, Kallunki, Pekka, additional, Christensen, Kenneth V., additional, Blackwood, Douglas H., additional, Muir, Walter J., additional, Straarup, Steen E., additional, Als, Thomas D., additional, Nordentoft, Merete, additional, Børglum, Anders D., additional, and Mors, Ole, additional
Published: 2010
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96. Support of association between BRD1 and both schizophrenia and bipolar affective disorder

Author: Nyegaard, Mette, primary, Severinsen, Jacob E., additional, Als, Thomas D., additional, Hedemand, Anne, additional, Straarup, Steen, additional, Nordentoft, Merete, additional, McQuillin, Andrew, additional, Bass, Nicholas, additional, Lawrence, Jacob, additional, Thirumalai, Srinivasa, additional, Pereira, Ana C.P., additional, Kandaswamy, Radhika, additional, Lydall, Gregory J., additional, Sklar, Pamela, additional, Scolnick, Edward, additional, Purcell, Shaun, additional, Curtis, David, additional, Gurling, Hugh M.D., additional, Mortensen, Preben B., additional, Mors, Ole, additional, and Børglum, Anders D., additional
Published: 2010
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97. A comparison of SNP and STR loci for delineating population structure and performing individual genetic assignment

Author: Glover, Kevin A, primary, Hansen, Michael M, additional, Lien, Sigbjørn, additional, Als, Thomas D, additional, Høyheim, Bjørn, additional, and Skaala, Øystein, additional
Published: 2010
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98. Reproductive isolation, evolutionary distinctiveness and setting conservation priorities: The case of European lake whitefish and the endangered North Sea houting (Coregonus spp.)

Author: Hansen, Michael M, primary, Fraser, Dylan J, additional, Als, Thomas D, additional, and Mensberg, Karen-Lise D, additional
Published: 2008
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99. Highly discrepant proportions of female and male Scandinavian and British Isles ancestry within the isolated population of the Faroe Islands

Author: Als, Thomas D, primary, Jorgensen, Tove H, additional, Børglum, Anders D, additional, Petersen, Peter A, additional, Mors, Ole, additional, and Wang, August G, additional
Published: 2006
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100. A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene.

Author: Gregersen, Noomi, Dahl, Hans A, Buttenschøn, Henriette N, Nyegaard, Mette, Hedemand, Anne, Als, Thomas D, Wang, August G, Joensen, Sofus, Woldbye, David PD, Koefoed, Pernille, Kristensen, Ann S, Kruse, Torben A, Børglum, Anders D, and Mors, Ole
Subjects: GENETIC polymorphisms, PANIC disorders, PANIC attacks, AMILORIDE, MENTAL illness
Abstract: Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using single-nucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case-control sample. However, analyses of a larger independent Danish case-control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population. [ABSTRACT FROM AUTHOR]
Published: 2012
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