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302 results on '"Amore, D."'

56. Synthesis and pharmacological properties of thieno[2',3':4,5]pyrimido [2,1-b][1,3,4]thiadiazine derivatives

Author

Santagati, A., Modica Maria, Santagati, M., Cutuli, V., Amore, D., and Caruso, A.

Subjects
Male, Rats, Sprague-Dawley, Analgesics, Mice, Magnetic Resonance Spectroscopy, Pyrimidines, Spectrophotometry, Infrared, Thiadiazines, Anti-Inflammatory Agents, Non-Steroidal, Animals, Rats
Abstract

A new series of 2-substituted-7,8-dimethyl-3H,9H-thieno[2',3':4,5]pyrimido[2,1- b][1,3,4]thiadiazin-9-ones 5a-d and 6a,b was synthesized through the hydrazinium(1+) salt of 3-amino-2,3-dihydro-5,6-dimethyl-2-thioxo- thieno[2,3-d]pyrimidin-4(1H)-one, 2. These derivatives and two analogs 10a,b were tested for their analgesic and antiinflammatory properties. The pharmacological results are discussed in comparison with those of related compounds previously tested.

Published
1995

99. Somatic symptoms, social support and traumatic events in forced migration: an observational study.

Author

Magliocchetti, V., Todini, L., Roselli, V., D'Amore, D., Carlone, L., Maraone, A., Giordani, R., Pasquini, M., Biondi, M., and Tarsitani, L.

Subjects
FORCED migration, SOCIAL support, PEARSON correlation (Statistics), SCIENTIFIC observation, POLITICAL refugees
Abstract

Introduction: Studies indicate that war-affected and displaced groups, compared to local non-refugee populations, suffer variable but generally higher rates of stress-related somatic symptoms. The relation between traumatic events and somatization is poorly explored. Objectives: To assess the impact of trauma on somatic symptoms in forced migrants recently hosted in Italy. Methods: First generation asylum seekers/refugees of age over 18 referred to Umberto I Hospital, Rome, for a routine infectivologic screening were consecutively enrolled. The following tools were administered: Somatic Symptom Scale 8 (SSS-8), Life Events Check List (LEC-5), and Stress-related Vulnerability Scale (SVS). Results: Eighty-five subjects participated to the study (males=80 (94.1%); mean age= 28.3 SD=7.4). Fifty-eight (68%) participants reported at least one clinically significant somatic symptom and all reported at least one severe traumatic event in the LEC-5. Pearson Correlation Coefficients of SSS-8 total score with respect to LEC-5 and SVS lack of Social Support Subscale score were r=0,327 (p=0.003), r=0.529 (p=0.0001). A stepwise linear regression confirmed that LEC-5 total score (Beta standardized correlation coefficient = 0.151; p = 0.027) and SVS lack of Social Support Subscale (Beta standardized correlation coefficient = -0.309; p = 0.010) were significant predictors of SSS-8 total score. Conclusions: High levels of somatization were associated to the number of lifetime traumatic events and to perceived lack of social support in forced migrants. It is important to correctly recognize somatic symptoms in traumatized forced migrants. [ABSTRACT FROM AUTHOR]

Published
2020

100. Single port VATS resection of a sessile solitary fibrous tumour of the visceral pleura. A case report

Author

Antonio Mazzella, Izzo, A., Amore, D., Cennamo, A., Cerqua, F. S., Perrotta, F., Mazzella, A., Izzo, A., Amore, D., Cennamo, A., Cerqua, F. S., and Perrotta, F.

Subjects
Surgery
Abstract

Il tumore fibroso solitario della pleura viscerale è una neoplasia rara che deriva dalle cellule mesenchimali adiacenti al tessuto mesoteliali di pleura. La resezione chirurgica è il trattamento di scelta nelle sia nelle lesione benigne che maligne. La recidiva locale può essere il risultato di una chirurgia incompleta o conservatrice, di una mancanza di identificazione dei lembi del tumore durante l’operazione o di crescita di una neoplasia sincrona indipendente da quello rimossa. La resezione chirurgica è anche gravata da qualche difficoltà come la dimensione del tumore, il rapporto con le strutture anatomiche viciniori e la identificazione del peduncolo vascolare. Riportiamo un caso di un uomo di 72 anni con un tumore fibroso solitario sessile della pleura viscerale. Il paziente è stato trattato mediante videotoracoscopia con approccio uniportale. Questo caso, rappresenta una resezione in VATS uniportale di un SFTP sessile con ampia base di impianto. In letteratura, solo due casi di SFTP sono stati trattati mediante approccio uniportale. In tutti i due casi, il tumore era piccolo (4x3 cm nel primo, nel secondo 33 x 22mm) e peduncolato. Nel nostro caso, si parla di un STFP di dimensioni maggiore, sessile e con larga base di impianto. I vantaggi dell’approccio uniportale rispetto alla tradizionale VATS triportale sono la riduzione del dolore post-operatorio, la minore durata di utilizzo dei tubi di drenaggio, la ridotta degenza ospedaliera ed un miglior risultato estetico. UNLABELLED: The solitary fibrous tumour of the visceral pleura is a rare neoplasm that derives from mesenchymal cells adjacent to the mesothelial tissue of pleura. Surgical resection is the treatment of choice in benign lesions and healing resulting in half of malignant. Local recurrence can occur in malignant cases, but it is very rare in solitary benign tumors. It may be a result of an incomplete or conservative surgery, lack of identification of a tumor during the operation or a growth of a synchronous neoplasm independent from that removed. Surgical resection is also burdened with some difficulty as the size of the tumor, the relationship with the adjacent structures and identification of the vascular peduncle. We report a case of 72 years-old male with a sessile left solitary fibrous tumour of the visceral pleura. The mass of 10 x 7 x 5 cm was attached, thanks to large planting base, to lateral basal segment of left lower lobe. The patient was treated by single port video assisted approach with a 4 cm skin incision. This case, in our knowledge, represents the first resection by single port VATS of a sessile SFTP with a large plating base and, more generally, the third SFTP resection treated by single portal access.KEY WORDS: Solitary fibrous tumour, Uniportal VATS.

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