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51. Author Correction: Serological responses and vaccine effectiveness for extended COVID-19 vaccine schedules in England

Author

Amirthalingam, Gayatri, Bernal, Jamie Lopez, Andrews, Nick J., Whitaker, Heather, Gower, Charlotte, Stowe, Julia, Tessier, Elise, Subbarao, Sathyavani, Ireland, Georgina, Baawuah, Frances, Linley, Ezra, Warrener, Lenesha, O’Brien, Michelle, Whillock, Corinne, Moss, Paul, Ladhani, Shamez N., Brown, Kevin E., and Ramsay, Mary E.

Published
2022
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53. GBS vaccines in the UK: a round table discussion

Author

Thorn, Natasha, primary, Guy, Rebecca L, additional, Karampatsas, Konstantinos, additional, Powell, Mair, additional, Walker, Kate F, additional, Plumb, Jane, additional, Khalil, Asma, additional, Greening, Vanessa, additional, Eccleston, Emma, additional, Trotter, Caroline, additional, Andrews, Nick, additional, Rush, Lynne, additional, Sharkey, Claire, additional, Wallis, Lauren, additional, Heath, Paul, additional, and Le Doare, Kirsty, additional

Published
2024
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54. Interim 2023/2024 Season Influenza Vaccine Effectiveness in Primary and Secondary Care in the United Kingdom

Author

Whitaker, Heather, primary, Findlay, Beth, additional, Zitha, Jana, additional, Goudie, Rosalind, additional, Hassell, Katie, additional, Evans, Josie, additional, Kalapotharakou, Panoraia, additional, Agrawal, Utkarsh, additional, Kele, Beatrix, additional, Hamilton, Mark, additional, Moore, Catherine, additional, Byford, Rachel, additional, Stowe, Julia, additional, Robertson, Chris, additional, Couzens, Anastasia, additional, Jamie, Gavin, additional, Hoschler, Katja, additional, Pheasant, Kathleen, additional, Button, Elizabeth, additional, Quinot, Catherine, additional, Jones, Tim, additional, Anand, Sneha, additional, Watson, Conall, additional, Andrews, Nick, additional, de Lusignan, Simon, additional, Zambon, Maria, additional, Williams, Christopher, additional, Cottrell, Simon, additional, Marsh, Kimberly, additional, McMenamin, Jim, additional, and Lopez Bernal, Jamie, additional

Published
2024
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55. End of 2022/23 Season Influenza Vaccine Effectiveness in Primary Care in Great Britain

Author

Whitaker, Heather J., primary, Willam, Naoma, additional, Cottrell, Simon, additional, Goudie, Rosalind, additional, Andrews, Nick, additional, Evans, Josie, additional, Moore, Catherine, additional, Agrawal, Utkarsh, additional, Hassell, Katie, additional, Gunson, Rory, additional, Zitha, Jana, additional, Anand, Sneha, additional, Sebastian‐Pillai, Praveen, additional, Kalapotharakou, Panoraia, additional, Okusi, Cecilia, additional, Hoschler, Katja, additional, Jamie, Gavin, additional, Kele, Beatrix, additional, Hamilton, Mark, additional, Couzens, Anastasia, additional, Quinot, Catherine, additional, Pheasant, Kathleen, additional, Byford, Rachel, additional, Marsh, Kimberly, additional, Robertson, Chris, additional, de Lusignan, Simon, additional, Williams, Christopher, additional, Zambon, Maria, additional, McMenamin, Jim, additional, and Watson, Conall H., additional

Published
2024
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56. Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

Author

Riordan, Andrew, Ustianowski, Andrew, Rogers, Chris A, Hughes, Stephen, Longshaw, Laura, Stockport, Jane, Hughes, Rachel, Grundy, Lynne, Tudor Jones, Lona, Guha, Arpan, Snashall, Emma, Eadsforth, Tom, Reeder, Sally, Storton, Kim, Munusamy, Malathi, Tandy, Bridget, Egbo, Akamino, Cox, Stephen, Ahmed, Nabeela Nazir, Shenoy, Anil, Bousfield, Rachel, Wixted, Donna, Gutteridge, Helen, Mansfield, Becky, Herbert, Christopher, Holliday, Kyra, Calderwood, James, Barker, Dominique, Brandon, Jacqueline, Tulloch, Hayley, Colquhoun, Suzie, Thorp, Helen, Radford, Helen, Evans, Julie, Baker, Helena, Thorpe, Jeanette, Batham, Sally, Hailstone, Jessica, Phillips, Rachael, Kumar, Dileep, Westwell, Fran, Makia, Fiona, Hopkins, NinaSimone, Barcella, Lara, Mpelembue, Mushiya, dabagh, Maja, lang, Matilda, khan, Farida, Adebambo, Olumide, Chita, Sunder, Corrah, Tumena, Whittington, Ashley, John, Laurence, Roche, Siobhan, Wagstaff, Lynda, Farrier, Adam, Bisnauthsing, Karen, Serafimova, Teona, Nanino, Elisa, Cooney, Enya, Wilson-Goldsmith, Jaimie, Nguyen, Hanna, Mazzella, Andrea, Jackson, Beth, Aslam, Suahil, Bawa, Tanveer, Broadhead, Samantha, Farooqi, Sadaf, Piper, Jo, Weighell, Rowena, Pickup, Lorinda, Shamtally, Djamila, Domingo, Jason, Kourampa, Evgenia, Hale, Colin, Gibney, Jennifer, Stackpoole, Michael, Rashid-Gardner, Zalina, Lyon, Rebecca, McDonnell, Chloe, Cole, Christine, Stewart, Anna, McMillan, Gillian, Savage, Mary, Beckett, Helen, Moorbey, Chantelle, Desai, Amisha, Brown, Claire, Naker, Kush, Qureshi, Ehsaan, Trinham, Charlotte, Sabine, Charlotte, Moore, Sophie, Hurdover, Steve, Justice, Edwin, Smith, David, Plested, Emma, Ferreira Da Silva, Carla, White, Rachel, Robinson, Hannah, Cifuentes, Liliana, Morshead, Gertraud, Drake-Brockman, Rachael, Kinch, Patrick, Kasanyinga, Mwila, Clutterbuck, Elizabeth A., Bibi, Sagida, Stuart, Arabella SV, Shaw, Robert H, Singh, Michael, Champaneri, Trishna, Irwin, Margaret, Khan, Mohammed, Kownacka, Alicja, Nabunjo, Martha, Osuji, Carool, Hladkiwskyj, John, Galvin, Dominic, Patel, Gita, Mouland, Johanna, Longhurst, Beverley, Moon, Maria, Giddins, Beth, Pereira Dias Alves, Carlota, Richmond, Leah, Minnis, Christine, Baryschpolec, Sonia, Elliott, Scott, Fox, Lauren, Graham, Victoria, Baker, Natalie, Godwin, Kerry, Buttigieg, Karren, Knight, Chanice, Brown, Phillip, Lall, Paminder, Shaik, Imam, Chiplin, Emily, Brunt, Emily, Leung, Stephanie, Allen, Lauren, Thomas, Steve, Fraser, Sara, Choi, Bea, Gouriet, Jade, Freedman, Andrew, Perkins, Jonathan, Gowland, Andrew, Macdonald, Jonathan, Seenan, John Paul, Starinskij, Igor, Seaton, Andrew, Peters, Erica, Singh, Stephen, Gardside, Ben, Bonnaud, Avril, Davies, Ceri, Gordon, Elizabeth, Keenan, Samantha, Hall, Jane, Wilkins, Suzanne, Tasker, Suzanne, James, Rob, Seath, Ingrid, Littlewood, Kelly, Newman, Joseph, Boubriak, Iryna, Suggitt, Debbie, Haydock, Helen, Bennett, Sara, Woodyatt, Wiesia, Hughes, Kerry, Bell, Judith, Coughlan, Tricia, van Welsenes, Donald, Kamal, Mohammed, Cooper, Chris, Tunstall, Simon, Ronan, Nicholas, Cutts, Rebecca, Dare, Tracey, Yim, Yee Ting Nicole, Whittley, Sarah, Ricamara, Marivic, Hamal, Shama, Adams, Kirsty, Baker, Holly, Driver, Kimberley, Turner, Nicola, Rawlins, Todd, Roy, Subarna, Merida-Morillas, Marta, Sakagami, Yukari, Andrews, Antonette, Goncalves cordeiro, Lillian, Stokes, Matthew, Ambihapathy, Wythehi, Spencer, Joanne, Parungao, Nina, Berry, Lisa, Cullinane, James, Presland, Laura, Ross-Russell, Amy, Warren, Sarah, Baker, Jonathan, Oliver, Abigail, Buadi, Amanda, Lee, Kim, Haskell, Louise, Romani, Rossana, Bentley, Ian, Whitbred, Tim, Fowler, Simon, Gavin, John, Magee, Alan, Watson, Tara, Nightingale, Kari, Marius, Phedra, Summerton, Eloise, Locke, Emily, Honey, Thomas, Lingwood, Aidan, de la Haye, Anastasia, Elliott, Ryan Stephen, Underwood, Karen, King, Mikayala, Davies-Dear, Sharon, Horsfall, Emily, Chalwin, Olivia, Burton, Holly, Edwards, Christopher J, Welham, Benjamin, Garrahy, Sarah, Hall, Fran, Ladikou, Eleni, Mullan, Dee, Hansen, Daniel, Campbell, Marion, Dos Santos, Filipa, Habash-Bailey, Haniah, Lakeman, Nicki, Branney, Debbie, Vamplew, Luke, Hogan, Alison, Frankham, Jorden, Wiselka, Martin, Vail, Dennyl, Wenn, Victoria, Renals, Valerie, Ellis, Kate, Lewis-Taylor, Jessica, Magan, Javier, Hardy, Anna, Appleby, Kim, Munro, Alasdair P S, Janani, Leila, Cornelius, Victoria, Aley, Parvinder K, Babbage, Gavin, Baxter, David, Bula, Marcin, Cathie, Katrina, Chatterjee, Krishna, Dodd, Kate, Enever, Yvanne, Gokani, Karishma, Goodman, Anna L, Green, Christopher A, Harndahl, Linda, Haughney, John, Hicks, Alexander, van der Klaauw, Agatha A, Kwok, Jonathan, Lambe, Teresa, Libri, Vincenzo, Llewelyn, Martin J, McGregor, Alastair C, Minassian, Angela M, Moore, Patrick, Mughal, Mehmood, Mujadidi, Yama F, Murira, Jennifer, Osanlou, Orod, Osanlou, Rostam, Owens, Daniel R, Pacurar, Mihaela, Palfreeman, Adrian, Pan, Daniel, Rampling, Tommy, Regan, Karen, Saich, Stephen, Salkeld, Jo, Saralaya, Dinesh, Sharma, Sunil, Sheridan, Ray, Sturdy, Ann, Thomson, Emma C, Todd, Shirley, Twelves, Chris, Read, Robert C, Charlton, Sue, Hallis, Bassam, Ramsay, Mary, Andrews, Nick, Nguyen-Van-Tam, Jonathan S, Snape, Matthew D, Liu, Xinxue, and Faust, Saul N

Published
2021
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57. Risk of myocarditis and pericarditis after a COVID-19 mRNA vaccine booster and after COVID-19 in those with and without prior SARS-CoV-2 infection: A self-controlled case series analysis in England

Author

Stowe, Julia, Miller, Elizabeth, Andrews, Nick, and Whitaker, Heather J.

Subjects
Myocarditis -- Risk factors -- Prevention, Pericarditis -- Risk factors -- Prevention, Biological sciences
Abstract

Background An increased risk of myocarditis or pericarditis after priming with mRNA Coronavirus Disease 2019 (COVID-19) vaccines has been shown but information on the risk post-booster is limited. With the now high prevalence of prior Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, we assessed the effect of prior infection on the vaccine risk and the risk from COVID-19 reinfection. Methods and findings We conducted a self-controlled case series analysis of hospital admissions for myocarditis or pericarditis in England between 22 February 2021 and 6 February 2022 in the 50 million individuals eligible to receive the adenovirus-vectored vaccine (ChAdOx1-S) for priming or an mRNA vaccine (BNT162b2 or mRNA-1273) for priming or boosting. Myocarditis and pericarditis admissions were extracted from the Secondary Uses Service (SUS) database in England and vaccination histories from the National Immunisation Management System (NIMS); prior infections were obtained from the UK Health Security Agency's Second-Generation Surveillance Systems. The relative incidence (RI) of admission within 0 to 6 and 7 to 14 days of vaccination compared with periods outside these risk windows stratified by age, dose, and prior SARS-CoV-2 infection for individuals aged 12 to 101 years was estimated. The RI within 27 days of an infection was assessed in the same model. There were 2,284 admissions for myocarditis and 1,651 for pericarditis in the study period. Elevated RIs were only observed in 16- to 39-year-olds 0 to 6 days postvaccination, mainly in males for myocarditis. Both mRNA vaccines showed elevated RIs after first, second, and third doses with the highest RIs after a second dose 5.34 (95% confidence interval (CI) [3.81, 7.48]; p < 0.001) for BNT162b2 and 56.48 (95% CI [33.95, 93.97]; p < 0.001) for mRNA-1273 compared with 4.38 (95% CI [2.59, 7.38]; p < 0.001) and 7.88 (95% CI [4.02, 15.44]; p < 0.001), respectively, after a third dose. For ChAdOx1-S, an elevated RI was only observed after a first dose, RI 5.23 (95% CI [2.48, 11.01]; p < 0.001). An elevated risk of admission for pericarditis was only observed 0 to 6 days after a second dose of mRNA-1273 vaccine in 16 to 39 year olds, RI 4.84 (95% CI [1.62, 14.01]; p = 0.004). RIs were lower in those with a prior SARS-CoV-2 infection than in those without, 2.47 (95% CI [1.32,4.63]; p = 0.005) versus 4.45 (95% [3.12, 6.34]; p = 0.001) after a second BNT162b2 dose, and 19.07 (95% CI [8.62, 42.19]; p < 0.001) versus 37.2 (95% CI [22.18, 62.38]; p < 0.001) for mRNA-1273 (myocarditis and pericarditis outcomes combined). RIs 1 to 27 days postinfection were elevated in all ages and were marginally lower for breakthrough infections, 2.33 (95% CI [1.96, 2.76]; p < 0.001) compared with 3.32 (95% CI [2.54, 4.33]; p < 0.001) in vaccine-naïve individuals respectively. Conclusions We observed an increased risk of myocarditis within the first week after priming and booster doses of mRNA vaccines, predominantly in males under 40 years with the highest risks after a second dose. The risk difference between the second and the third doses was particularly marked for the mRNA-1273 vaccine that contains half the amount of mRNA when used for boosting than priming. The lower risk in those with prior SARS-CoV-2 infection, and lack of an enhanced effect post-booster, does not suggest a spike-directed immune mechanism. Research to understand the mechanism of vaccine-associated myocarditis and to document the risk with bivalent mRNA vaccines is warranted., Author(s): Julia Stowe 1, Elizabeth Miller 2,*, Nick Andrews 1, Heather J. Whitaker 1 Introduction The rapid development and global deployment of Coronavirus Disease 2019 (COVID-19) vaccines based on mRNA [...]

Published
2023
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59. Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial

Author

Munro, Alasdair P S, Bartholomew, Jazz, Presland, Laura, Horswill, Sarah, Warren, Sarah, Varkonyi-Clifford, Sophie, Saich, Stephen, Adams, Kirsty, Ricamara, Marivic, Turner, Nicola, Yee Ting, Nicole Y, Whittley, Sarah, Rampling, Tommy, Desai, Amisha, Brown, Claire H, Qureshi, Ehsaan, Gokani, Karishma, Naker, Kush, Kellett Wright, Johanna K, Williams, Rachel L, Riaz, Tawassal, Penciu, Florentina D, Di Maso, Claudio, Howe, Elizabeth G, Vichos, Iason, Ghulam Farooq, Mujtaba, Noristani, Rabiullah, Yao, Xin L, Oldfield, Neil J, Hammersley, Daniel, Belton, Sue, Royal, Simon, San Francisco Ramos, Alberto, Hultin, Cecilia, Galiza, Eva P, Shiham, Farah, Solórzano, Carla, Sainsbury, Hannah, Davies, Kelly, Ambrose, Pauline, Hitchins, Lisa, Baker, Natalie, Leung, Stephanie, Fothergill, Ross, Godwin, Kerry, Buttigieg, Karen, Shaik, Imam, Brown, Phill, Knight, Chanice, Lall, Paminder, Allen, Lauren, Liu, Xinxue, Shaw, Robert H, Stuart, Arabella S V, Greenland, Melanie, Aley, Parvinder K, Andrews, Nick J, Cameron, J Claire, Charlton, Sue, Clutterbuck, Elizabeth A, Collins, Andrea M, Dinesh, Tanya, England, Anna, Faust, Saul N, Ferreira, Daniela M, Finn, Adam, Green, Christopher A, Hallis, Bassam, Heath, Paul T, Hill, Helen, Lambe, Teresa, Lazarus, Rajeka, Libri, Vincenzo, Long, Fei, Mujadidi, Yama F, Plested, Emma L, Provstgaard-Morys, Samuel, Ramasamy, Maheshi N, Ramsay, Mary, Read, Robert C, Robinson, Hannah, Singh, Nisha, Turner, David P J, Turner, Paul J, Walker, Laura L, White, Rachel, Nguyen-Van-Tam, Jonathan S, and Snape, Matthew D

Published
2021
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60. Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling.

Author

Cobos, Enrique J, Nickerson, Chelsea A, Gao, Fuying, Chandran, Vijayendran, Bravo-Caparrós, Inmaculada, González-Cano, Rafael, Riva, Priscilla, Andrews, Nick A, Latremoliere, Alban, Seehus, Corey R, Perazzoli, Gloria, Nieto, Francisco R, Joller, Nicole, Painter, Michio W, Ma, Chi Him Eddie, Omura, Takao, Chesler, Elissa J, Geschwind, Daniel H, Coppola, Giovanni, Rangachari, Manu, Woolf, Clifford J, and Costigan, Michael

Subjects
T-Lymphocytes, Macrophages, Animals, Mice, Inbred C57BL, Mice, Transgenic, Mice, Neuralgia, Hyperalgesia, Behavior, Animal, Touch, Male, TRPV Cation Channels, Cold Temperature, Sensory Receptor Cells, Transcriptome, T cells, TrpV1, WCGNA, cold allodynia, gene expression, immune system, macrophages, neuropathic pain, tactile allodynia, transcript profiling, Inbred C57BL, Transgenic, Behavior, Animal, Pain Research, Chronic Pain, Peripheral Neuropathy, Neurodegenerative, Neurosciences, Clinical Research, 2.1 Biological and endogenous factors, Neurological, Pain Conditions - Chronic, Biochemistry and Cell Biology, Medical Physiology
Abstract

Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a common symptom. Here, we demonstrate that the onset of cold hypersensitivity precedes tactile allodynia in a model of partial nerve injury, and this temporal divergence was associated with major differences in global gene expression in innervating dorsal root ganglia. Transcripts whose expression change correlates with the onset of cold allodynia were nociceptor related, whereas those correlating with tactile hypersensitivity were immune cell centric. Ablation of TrpV1 lineage nociceptors resulted in mice that did not acquire cold allodynia but developed normal tactile hypersensitivity, whereas depletion of macrophages or T cells reduced neuropathic tactile allodynia but not cold hypersensitivity. We conclude that neuropathic pain incorporates reactive processes of sensory neurons and immune cells, each leading to distinct forms of hypersensitivity, potentially allowing drug development targeted to each pain type.

Published
2018

62. COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

Author

Andrews, N, Atti, A, Aziz, H, Brooks, T, Brown, CS, Camero, D, Carr, C, Chand, MA, Charlett, A, Crawford, H, Cole, M, Conneely, J, D'Arcangelo, S, Ellis, J, Evans, S, Foulkes, S, Gillson, N, Gopal, R, Hall, L, Hall, VJ, Harrington, P, Hopkins, S, Hewson, J, Hoschler, K, Ironmonger, D, Islam, J, Kall, M, Karagiannis, I, Kay, O, Khawam, J, King, E, Kirwan, P, Kyffin, R, Lackenby, A, Lattimore, M, Linley, E, Lopez-Bernal, J, Mabey, L, McGregor, R, Miah, S, Monk, EJM, Munro, K, Naheed, Z, Nissr, A, O'Connell, AM, Oguti, B, Okafor, H, Organ, S, Osbourne, J, Otter, A, Patel, M, Platt, S, Pople, D, Potts, K, Ramsay, M, Robotham, J, Rokadiya, S, Rowe, C, Saei, A, Sebbage, G, Semper, A, Shrotri, M, Simmons, R, Soriano, A, Staves, P, Taylor, S, Taylor, A, Tengbe, A, Tonge, S, Vusirikala, A, Wallace, S, Wellington, E, Zambon, M, Corrigan, D, Sartaj, M, Cromey, L, Campbell, S, Braithwaite, K, Price, L, Haahr, L, Stewart, S, Lacey, ED, Partridge, L, Stevens, G, Ellis, Y, Hodgson, H, Norman, C, Larru, B, Mcwilliam, S, Roynon, A, Northfield, J, Winchester, S, Cieciwa, P, Pai, A, Bakker, P, Loughrey, C, Watt, A, Adair, F, Hawkins, A, Grant, A, Temple-Purcell, R, Howard, J, Slawson, N, Subudhi, C, Davies, S, Bexley, A, Penn, R, Wong, N, Boyd, G, Rajgopal, A, Arenas-Pinto, A, Matthews, R, Whileman, A, Laugharne, R, Ledger, J, Barnes, T, Jones, C, Osuji, N, Chitalia, N, Bailey, T, Akhtar, S, Harrison, G, Horne, S, Walker, N, Agwuh, K, Maxwell, V, Graves, J, Williams, S, O'Kelly, A, Ridley, P, Cowley, A, Johnstone, H, Swift, P, Democratis, J, Meda, M, Brake, S, Gunn, J, Selassi, A, Hams, S, Irvine, V, Chandrasekaran, B, Forsyth, C, Radmore, J, Thomas, C, Brown, K, Roberts, S, Burns, P, Gajee, K, Lewis, T, Byrne, TM, Sanderson, F, Knight, S, Macnaughton, E, Burton, BJL, Smith, H, Chaudhuri, R, Aeron-Thomas, J, Hollinshead, K, Shorten, RJ, Swan, A, Favager, C, Murira, J, Baillon, S, Hamer, S, Shah, A, Russell, J, Brennan, D, Dave, A, Chawla, A, Westwell, F, Adeboyeku, D, Papineni, P, Pegg, C, Williams, M, Ahmad, S, Horsley, A, Gabriel, C, Pagget, K, Maloney, G, Ashcroft, J, Del Rosario, I, Crosby-Nwaobi, R, Flanagan, D, Dhasmana, D, Fowler, S, Cameron, E, Prentice, L, Sinclair, C, Bateman, V, McLelland-Brooks, K, Ho, A, Murphy, M, Cochrane, A, Gibson, A, Black, K, Tempeton, K, Donaldson, S, Coke, L, Elumogo, N, Elliott, J, Padgett, D, Cross, A, Mirfenderesky, M, Joyce, S, Sinanovic, I, Howard, M, Cowling, P, Brazil, M, Hanna, E, Abdelrazik, A, Brand, S, Sheridan, EA, Wadams, B, Lloyd, A, Mouland, J, Giles, J, Pottinger, G, Coles, H, Joseph, M, Lee, M, Orr, S, Chenoweth, H, Browne, D, Auckland, C, Lear, R, Mahungu, T, Rodger, A, Warren, S, Brooking, D, Pai, S, Druyeh, R, Smith, E, Stone, S, Meisner, S, Delgado, D, Underhill, E, Keen, L, Aga, M, Domingos, P, Gormley, S, Kerrison, C, Birch, S, DeSilva, T, Allsop, L, Ambalkar, S, Beekes, M, Jose, S, Tomlinson, J, Painter, Sharen, Price, C, Pepperell, J, James, K, Trinick, T, Moore, L, Day, J, Boulos, A, Knox, I, Defever, E, McCracken, D, Gray, K, Houston, A, Planche, T, Pritchard Jones, R, Wycherley, Diane, Bennett, S, Marrs, J, Nimako, K, Stewart, B, Bain, SC, Kalakonda, N, Khanduri, S, Ashby, A, Holden, M, Mahabir, N, Harwood, J, Payne, B, Court, K, White, N, Longfellow, R, Hughes, LE, Green, ME, Halkes, M, Mercer, P, Roebuck, A, Wilson-Davies, E, Gallego, L, Lazarus, R, Aldridge, N, Berry, L, Game, F, Reynolds, T, Holmes, C, Wiselka, M, Higham, A, Booth, M, Duff, C, Alderton, J, Hilton, D, Powell, J, Jackson, A, Plant, AJ, Ahmed, N, Chin, T, Qazzafi, MZ, Moody, AM, Tilley, RE, Donaghy, T, O'Kane, M, Shipman, K, Sierra, R, Parmar, C, Mills, G, Harvey, D, Huang, YWJ, Birch, J, Robinson, L, Board, S, Broadley, A, Laven, C, Todd, N, Eyre, DW, Jeffery, K, Dunachie, S, Duncan, C, Klenerman, P, Turtle, L, Baxendale, H, Heeney, JL, Hall, Victoria Jane, Foulkes, Sarah, Saei, Ayoub, Andrews, Nick, Oguti, Blanche, Charlett, Andre, Wellington, Edgar, Stowe, Julia, Gillson, Natalie, Atti, Ana, Islam, Jasmin, Karagiannis, Ioannis, Munro, Katie, Khawam, Jameel, Chand, Meera A, Brown, Colin S, Ramsay, Mary, Lopez-Bernal, Jamie, and Hopkins, Susan

Published
2021
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63. Immunogenicity of the UK group B meningococcal vaccine (4CMenB) schedule against groups B and C meningococcal strains (Sched3): outcomes of a multicentre, open-label, randomised controlled trial

Author

Davis, Kimberly, Valente Pinto, Marta, Andrews, Nick J, Goldblatt, David, Borrow, Ray, Findlow, Helen, Southern, Jo, Partington, Jo, Plested, Emma, Patel, Sima, Holland, Ann, Matheson, Mary, England, Anna, Hallis, Bassam, Miller, Elizabeth, and Snape, Matthew D

Published
2021
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64. Serological surveillance of SARS-CoV-2: Six-month trends and antibody response in a cohort of public health workers

Author

Harris, Ross J., Whitaker, Heather J., Andrews, Nick J., Aiano, Felicity, Amin-Chowdhury, Zahin, Flood, Jessica, Borrow, Ray, Linley, Ezra, Ahmad, Shazaad, Stapley, Lorraine, Hallis, Bassam, Amirthalingam, Gayatri, Höschler, Katja, Parker, Ben, Horsley, Alex, Brooks, Timothy J.G., Brown, Kevin E., Ramsay, Mary E., and Ladhani, Shamez N.

Published
2021
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68. Characterising the Shape of Mathematics Teaching Decisions Made over Time: An Application of Tri-Polar Analysis

Author

Andrews, Nick

Abstract

Focussing on teachers' subject pedagogical actions over the course of a series of lessons on a mathematical topic, this paper sets out an original analytical approach to characterise the shape of mathematics teaching decisions made over time: tri-polar analysis. The notion of manifestation is introduced as a way of categorising how the teacher is observed making content available to learners and the analysis explores sequencing and differences in emphasis of these categories across a lesson series. These differences are presented graphically and the implications for doing so in terms of opportunities for teachers' professional learning are discussed. The analytical approach is exemplified through the case of Ashley. Prominent between-lesson differences are discerned that suggest systematic variation in what is emphasised across the lesson series, consistent with deliberate and planned decision-making. But subtler between-lesson differences are also revealed through the analysis associated with in-flight decision-making.

Published
2020
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69. When Students Offer Explanations without the Teacher Explicitly Asking Them To

Author

Ingram, Jenni, Andrews, Nick, and Pitt, Andrea

Abstract

The act of explaining can help students to develop new understandings of mathematical ideas, construct rules for solving problems, become aware of misunderstandings or a lack of understanding and develop their mathematical communication. Their explanations can also offer opportunities for a teacher to understand more fully what the students are thinking. Yet, previous research has focused mainly on tasks, questions and other teacher actions that prompt student explanations and on generalising what counts as an explanation. Using a conversation analytic approach, transcripts of mathematics lessons from different schools and different teachers were analysed, looking specifically at the interactions where students gave explanations. This paper describes two interactional contexts where students gave explanations without being explicitly asked for one by the teacher. The structures and content of the interactions in which these student explanations occur reveal further ways in which teachers can encourage students to offer explanations beyond asking how or why questions. We suggest that awareness of the underlying structures of interactions is likely to leave the teacher better equipped to exploit such situations as they arise in their classrooms.

Published
2019
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70. Seroprevalence of SARS-CoV-2 among Blood Donors and Changes after Introduction of Public Health and Social Measures, London, UK

Author

Amirthalingam, Gayatri, Whitaker, Heather, Brooks, Tim, Brown, Kevin, Hoschler, Katja, Linley, Ezra, Borrow, Ray, Brown, Colin, Watkins, Nick, Roberts, David J., Solomon, Danielle, Gower, Charlotte M., Waroux, Olivier le Polain de, Andrews, Nick J., and Ramsay, Mary E.

Subjects
Epidemics -- Statistics -- Control -- United Kingdom, Blood donors -- Statistics -- Health aspects, Health
Abstract

The first confirmed cases of coronavirus disease (COVID-19) in the United Kingdom were identified at the end of January 2020. As cases increased across all regions, surveillance data indicated that [...]

Published
2021
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71. Quantifying and Adjusting for Confounding From Health-Seeking Behavior and Health Care Access in Observational Research.

Author

Graham, Sophie, Walker, Jemma L, Andrews, Nick, Hulme, William J, Nitsch, Dorothea, Parker, Edward P K, and McDonald, Helen I

Subjects
FLU vaccine efficacy, HEALTH services accessibility, HEALTH behavior, VACCINATION, VACCINE effectiveness
Abstract

Background Health-seeking behavior and health care access (HSB/HCA) are recognized confounders in many observational studies but are not directly measurable in electronic health records. We used proxy markers of HSB/HCA to quantify and adjust for confounding in observational studies of influenza and COVID-19 vaccine effectiveness (VE). Methods This cohort study used primary care data prelinked to secondary care and death data in England. We included individuals aged ≥66 years on 1 September 2019 and assessed influenza VE in the 2019–2020 season and early COVID-19 VE (December 2020–March 2021). VE was estimated with sequential adjustment for demographics, comorbidities, and 14 markers of HSB/HCA. Influenza vaccination in the 2019–2020 season was also considered a negative control exposure against COVID-19 before COVID-19 vaccine rollout. Results We included 1 991 284, 1 796 667, and 1 946 943 individuals in the influenza, COVID-19, and negative control exposure populations, respectively. Markers of HSB/HCA were positively correlated with influenza and COVID-19 vaccine uptake. For influenza, adjusting for HSB/HCA markers in addition to demographics and comorbidities increased VE against influenza-like illness from −1.5% (95% CI, −3.2% to.1%) to 7.1% (95% CI, 5.4%–8.7%) with a less apparent trend for more severe outcomes. For COVID-19, adjusting for HSB/HCA markers did not change VE estimates against infection or severe disease (eg, 2 doses of BNT162b2 against infection: 82.8% [95% CI, 78.4%–86.3%] to 83.1% [95% CI, 78.7%–86.5%]). Adjusting for HSB/HCA markers removed bias in the negative control exposure analysis (−7.5% [95% CI, −10.6% to −4.5%] vs −2.1% [95% CI, −6.0% to 1.7%] before vs after adjusting for HSB/HCA markers). Conclusions Markers of HSB/HCA can be used to quantify and account for confounding in observational vaccine studies. [ABSTRACT FROM AUTHOR]

Published
2024
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72. Risk factors for SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study

Author

de Lusignan, Simon, Dorward, Jienchi, Correa, Ana, Jones, Nicholas, Akinyemi, Oluwafunmi, Amirthalingam, Gayatri, Andrews, Nick, Byford, Rachel, Dabrera, Gavin, Elliot, Alex, Ellis, Joanna, Ferreira, Filipa, Lopez Bernal, Jamie, Okusi, Cecilia, Ramsay, Mary, Sherlock, Julian, Smith, Gillian, Williams, John, Howsam, Gary, Zambon, Maria, Joy, Mark, and Hobbs, F D Richard

Published
2020
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73. Safety of live attenuated influenza vaccine (LAIV) in children with moderate to severe asthma

Author

Adams, Alexandra, Doyle, Christine, Erlewyn-Lajeunesse, Michel, Fidler, Katy, Fleming, Louise, Gupta, Atul, Hughes, Stephen M., Ives, Andrew, Jay, Nicola, Kansra, Sonal, Michaelis, Louise, Moss, Samantha, Murray, Clare, Nagakumar, Prasad, Roberts, Graham, Saglani, Sejal, Seddon, Paul, Sinha, Ian, Stiefel, Gary, Thomas, Huw M., Turner, Paul J., Southern, Jo, Andrews, Nick J., and Miller, Elizabeth

Published
2020
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75. Interlaboratory comparison of a multiplex immunoassay that measures human serum IgG antibodies against six-group B streptococcus polysaccharides

Author

Le Doare, Kirsty, primary, Gaylord, Michelle A., additional, Anderson, Annaliesa S., additional, Andrews, Nick, additional, Baker, Carol J., additional, Bolcen, Shanna, additional, Felek, Arif, additional, Giardina, Peter C., additional, Grube, Christopher D., additional, Hall, Tom, additional, Hallis, Bassam, additional, Izu, Alane, additional, Madhi, Shabir A., additional, Maniatis, Pete, additional, Matheson, Mary, additional, Mawas, Fatme, additional, McKeen, Andrew, additional, Rhodes, Julia, additional, Alston, Bailey, additional, Patel, Palak, additional, Schrag, Stephanie, additional, Simon, Raphael, additional, Tan, Charles Y., additional, Taylor, Stephen, additional, Kwatra, Gaurav, additional, and Gorringe, Andrew, additional

Published
2024
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76. Excess mortality in Europe coincides with peaks of COVID-19, influenza and respiratory syncytial virus (RSV), November 2023 to February 2024

Author

Nørgaard, Sarah K, primary, Nielsen, Jens, additional, Nordholm, Anne Christine, additional, Richter, Lukas, additional, Chalupka, Alena, additional, Sierra, Natalia Bustos, additional, Braeye, Toon, additional, Athanasiadou, Maria, additional, Lytras, Theodore, additional, Denissov, Gleb, additional, Luomala, Oskari, additional, Fouillet, Anne, additional, Pontais, Isabelle, additional, an der Heiden, Matthias, additional, Zacher, Benedikt, additional, Weigel, Alina, additional, Foppa, Ivo, additional, Gkolfinopoulou, Kassiani, additional, Panagoulias, Ioannis, additional, Paldy, Anna, additional, Malnasi, Tibor, additional, Domegan, Lisa, additional, Kelly, Eva, additional, Rotem, Naama, additional, Rakhlin, Oksana, additional, de'Donato, Francesca K, additional, Di Blasi, Chiara, additional, Hoffmann, Patrick, additional, Velez, Telma, additional, England, Kathleen, additional, Calleja, Neville, additional, van Asten, Liselotte, additional, Jongenotter, Femke, additional, Rodrigues, Ana Paula, additional, Silva, Susana, additional, Klepac, Petra, additional, Gomez-Barroso, Diana, additional, Gomez, Inmaculada Leon, additional, Galanis, Ilias, additional, Farah, Ahmed, additional, Weitkunat, Rolf, additional, Fehst, Katarina, additional, Andrews, Nick, additional, Clare, Tom, additional, Bradley, Declan T, additional, O'Doherty, Mark G, additional, William, Naoma, additional, Hamilton, Mark, additional, Søborg, Bolette, additional, Krause, Tyra G, additional, Bundle, Nick, additional, and Vestergaard, Lasse S, additional

Published
2024
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77. Antibody kinetics between birth and three months of life in healthy infants with natural exposure to Group B streptococcus: A UK cohort study

Author

Karampatsas, Konstantinos, primary, Hall, Tom, additional, Voysey, Merryn, additional, Carreras-Abad, Clara, additional, Cochet, Madeleine, additional, Ramkhelawon, Laxmee, additional, Peregrine, Elisabeth, additional, Andrews, Nick, additional, Heath, Paul T., additional, and Le Doare, Kirsty, additional

Published
2024
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83. Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations.

Author

Andrews, Nick A, Latrémolière, Alban, Basbaum, Allan I, Mogil, Jeffrey S, Porreca, Frank, Rice, Andrew SC, Woolf, Clifford J, Currie, Gillian L, Dworkin, Robert H, Eisenach, James C, Evans, Scott, Gewandter, Jennifer S, Gover, Tony D, Handwerker, Hermann, Huang, Wenlong, Iyengar, Smriti, Jensen, Mark P, Kennedy, Jeffrey D, Lee, Nancy, Levine, Jon, Lidster, Katie, Machin, Ian, McDermott, Michael P, McMahon, Stephen B, Price, Theodore J, Ross, Sarah E, Scherrer, Grégory, Seal, Rebecca P, Sena, Emily S, Silva, Elizabeth, Stone, Laura, Svensson, Camilla I, Turk, Dennis C, and Whiteside, Garth

Subjects
Humans, Pain, Analgesics, Evidence-Based Medicine, Research Design, Bias, Transparent reporting, Consensus, Internal validity, Anesthesiology, Medical and Health Sciences, Psychology and Cognitive Sciences
Abstract

There is growing concern about lack of scientific rigor and transparent reporting across many preclinical fields of biological research. Poor experimental design and lack of transparent reporting can result in conscious or unconscious experimental bias, producing results that are not replicable. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the U.S. Food and Drug Administration sponsored a consensus meeting of the Preclinical Pain Research Consortium for Investigating Safety and Efficacy (PPRECISE) Working Group. International participants from universities, funding agencies, government agencies, industry, and a patient advocacy organization attended. Reduction of publication bias, increasing the ability of others to faithfully repeat experimental methods, and increased transparency of data reporting were specifically discussed. Parameters deemed essential to increase confidence in the published literature were clear, specific reporting of an a priori hypothesis and definition of primary outcome measure. Power calculations and whether measurement of minimal meaningful effect size to determine these should be a core component of the preclinical research effort provoked considerable discussion, with many but not all agreeing. Greater transparency of reporting should be driven by scientists, journal editors, reviewers, and grant funders. The conduct of high-quality science that is fully reported should not preclude novelty and innovation in preclinical pain research, and indeed, any efforts that curtail such innovation would be misguided. We believe that to achieve the goal of finding effective new treatments for patients with pain, the pain field needs to deal with these challenging issues.

Published
2016

88. UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records

Author

Walker, Jemma L., Grint, Daniel J., Strongman, Helen, Eggo, Rosalind M., Peppa, Maria, Minassian, Caroline, Mansfield, Kathryn E., Rentsch, Christopher T., Douglas, Ian J., Mathur, Rohini, Wong, Angel Y. S., Quint, Jennifer K., Andrews, Nick, Bernal, Jamie Lopez, Scott, J. Anthony, Ramsay, Mary, Smeeth, Liam, and McDonald, Helen I.

Published
2021
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96. Association between COVID-19 Vaccination and SARS-CoV-2 Infection among Household Contacts of Infected Individuals: A Prospective Household Study in England

Author

Muhsen, Khitam, primary, Waight, Pauline A., additional, Kirsebom, Freja, additional, Andrews, Nick, additional, Letley, Louise, additional, Gower, Charlotte M., additional, Skarnes, Catriona, additional, Quinot, Catherine, additional, Lunt, Rachel, additional, Bernal, Jamie Lopez, additional, Flasche, Stefan, additional, and Miller, Elizabeth, additional

Published
2024
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98. Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohort

Author

Kirwan, Peter D., primary, Hall, Victoria J., additional, Foulkes, Sarah, additional, Otter, Ashley D., additional, Munro, Katie, additional, Sparkes, Dominic, additional, Howells, Anna, additional, Platt, Naomi, additional, Broad, Jonathan, additional, Crossman, David, additional, Norman, Chris, additional, Corrigan, Diane, additional, Jackson, Christopher H., additional, Cole, Michelle, additional, Brown, Colin S., additional, Atti, Ana, additional, Islam, Jasmin, additional, Presanis, Anne M., additional, Charlett, Andre, additional, De Angelis, Daniela, additional, Hopkins, Susan, additional, Lewis, Tracy, additional, Bain, Steve, additional, Thomas, Rebeccah, additional, Geen, John, additional, Pothecary, Carla, additional, Cutler, Sean, additional, Northfield, John, additional, Price, Cathy, additional, Tomlinson, Johanne, additional, Knight, Sarah, additional, Macnaughton, Emily, additional, Watson, Ekaterina, additional, Lazarus, Rajeka, additional, Sinclair, Aaran, additional, Galliford, Joanne, additional, Masunda, Bridgett, additional, Mahungu, Tabitha, additional, Rodger, Alison, additional, Hanison, Esther, additional, Warren, Simon, additional, Jain, Swati, additional, Mirfenderesky, Mariyam, additional, Mahabir, Natasha, additional, Pritchard-Jones, Rowan, additional, Wycherley, Diane, additional, Gabriel, Claire, additional, Matovu, Elijah, additional, Bakker, Philippa, additional, Guha, Simantee, additional, Gormley, S., additional, Pethick, James, additional, Butt, Georgina, additional, Pepper, Stacey, additional, Bedford, Luke, additional, Ridley, Paul, additional, Democratis, Jane, additional, Meda, Manjula, additional, Chawla, Anu, additional, Westwell, Fran, additional, Kalakonda, Nagesh, additional, Khanduri, Sheena, additional, Doel, Allison, additional, Pai, Sumita, additional, Hacon, Christian, additional, Nwaka, Davis, additional, Moro, Veronica Mendez, additional, Moody, A., additional, Auckland, Cressida, additional, Prince, Stephanie, additional, de Silva, Thushan, additional, Shulver, Helen, additional, Shah, A., additional, Jones, C., additional, Subhro-Osuji, Banerjee, additional, Houston, Angela, additional, Planche, Tim, additional, Booth, Martin, additional, Duff, Christopher, additional, Aeron-Thomas, Jonnie, additional, Chaudhuri, Ray, additional, Hilton, David, additional, Jory, Hannah, additional, Al-Khafaji, Zehra'a, additional, Kemsley, Philippa, additional, Longfellow, Ruth, additional, Boss, David, additional, Brake, Simon, additional, Coke, Louise, additional, Elumogo, Ngozi, additional, Latham, Scott, additional, Subudhi, Chinari, additional, Hoad, Ina, additional, Thomas, Claire, additional, Chitalia, Nihil, additional, Edmunds, Tracy, additional, Ashby, Helen, additional, Elliott, John, additional, Wilkinson, Beverley, additional, Rand, Abby, additional, Thompson, Catherine, additional, Agwuh, K., additional, Grice, Anna, additional, Moran, Kelly, additional, Waykar, Vijayendra, additional, Lester, Yvonne, additional, Sach, Lauren, additional, Court, Kathryn, additional, White, Nikki, additional, Favager, Clair, additional, Holliday, Kyra, additional, Harwood, Jayne, additional, Payne, Brendan, additional, Burns, Karen, additional, Fothergill, Lynda, additional, Arenas-Pinto, Alejandro, additional, Severn, Abigail, additional, Brown, Kerryanne, additional, Gray, Katherine, additional, Dare, Jane, additional, Zheng, Qi, additional, Hollinshead, Kathryn, additional, Shorten, Robert, additional, Roebuck, Alun, additional, Holmes, Christopher, additional, Wiselka, Martin, additional, Faris, Barzo, additional, Marsh, Liane, additional, McAdam, Clare, additional, Ditchfield, Lisa, additional, Qazzafi, Zaman, additional, Boyd, G., additional, Wong, N., additional, Brand, Sarah, additional, Squires, Jack, additional, Ashcroft, John, additional, Rosario, Ismaelette Del, additional, Howard, Joanne, additional, Ward, Emma, additional, Harrison, Gemma, additional, Morgan, Joely, additional, Corless, Claire, additional, Penn, Ruth, additional, Wong, Nick, additional, Bagary, Manny, additional, Starkova, Nadezda, additional, Beekes, Mandy, additional, Carnahan, Mandy, additional, Khan, Shivani, additional, Mackay, Shekoo, additional, Lewis, Keneisha, additional, Pickard, Graham, additional, Dawson, Joy, additional, Finlayson, Lauren, additional, Cameron, Euan, additional, Todd, Anne, additional, Fagegaltier, Sebastien, additional, Mavin, Sally, additional, Cochrane, Alexandra, additional, Gibson, Andrew, additional, Donaldson, Sam, additional, Templeton, Kate, additional, Malcolm, Martin, additional, Smith, Beth, additional, Dhasmana, Devesh, additional, Fowler, Susan, additional, Ho, Antonia, additional, Murphy, Michael, additional, Beith, Claire, additional, Patel, Manish, additional, Boyd, Elizabeth, additional, Irvine, Val, additional, Grant, Alison, additional, Temple-Purcell, Rebecca, additional, Loughrey, Clodagh, additional, Hanna, Elinor, additional, Johnston, Frances, additional, Boulos, Angel, additional, Thompson, Fiona, additional, Protaschik, Yuri, additional, Regan, Susan, additional, Donaghy, Tracy, additional, O'Kane, Maurice, additional, Akinbami, Omolola, additional, Barbero, Paola, additional, Brooks, Tim, additional, Chand, Meera, additional, Insalata, Ferdinando, additional, Joshi, Palak, additional, O'Connell, Anne-Marie, additional, Ramsay, Mary, additional, Saei, Ayoub, additional, Zambon, Maria, additional, Linley, Ezra, additional, Tonge, Simon, additional, Adaji, Enemona, additional, Adebiyi, Omoyeni, additional, Andrews, Nick, additional, Conneely, Joanna, additional, Conneely, Paul, additional, Dunne, Angela, additional, Dyer, Simone, additional, Emmett, Hannah, additional, Hettiarachchi, Nipunadi, additional, Kapirial, Nishanthan, additional, Khawam, Jameel, additional, Monk, Edward, additional, Russell, Sophie, additional, Taylor-Kerr, Andrew, additional, Timeyin, Jean, additional, D'Arcangelo, Silvia, additional, Rowe, Cathy, additional, Semper, Amanda, additional, Gallagher, Eileen, additional, Kyffin, Robert, additional, Cromey, Lisa, additional, Areghan, Desmond, additional, Bishop, Jennifer, additional, Dembinsky, Melanie, additional, Dobbie, Laura, additional, Evans, Josie, additional, Goldberg, David, additional, Haahr, Lynne, additional, Jorgenson, Annelysse, additional, Matuluko, Ayodeji, additional, Naismith, Laura, additional, Nuryunarsih, Desy, additional, Olaoye, Alexander, additional, Plank, Caitlin, additional, Price, Lesley, additional, Sergenson, Nicole, additional, Stewart, Sally, additional, Telfer, Andrew, additional, Weir, Jennifer, additional, De Lacy, Ellen, additional, Ellis, Yvette, additional, Froude, Susannah, additional, Stevens, Guy, additional, Tyson, Linda, additional, Dunachie, Susanna, additional, Klenerman, Paul, additional, Duncan, Chris, additional, Payne, Rebecca, additional, Turtle, Lance, additional, Richter, Alex, additional, De Silva, Thushan, additional, Barnes, Eleanor, additional, Wootton, Daniel, additional, Galgut, Oliver, additional, Heeney, Jonathan, additional, Baxendale, Helen, additional, Castillo-Olivares, Javier, additional, Beale, Rupert, additional, Carr, Edward, additional, Barclay, Wendy, additional, Moshe, Maya, additional, Palmarini, Massimo, additional, Willett, Brian, additional, Baillie, John Kenneth, additional, Evans, Jennie, additional, and Aquino, Erika, additional

Published
2024
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