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Objective To evaluate the immediate, long-term, and carry-over effects of nasopharyngoscopic biofeedback therapy in patients with cleft palate who exhibit velopharyngeal dysfunction (VPD). Design Pre- versus posttreatment and follow-up comparisons. Setting Cleft palate center of the Heidelberg University Hospital, Heidelberg, Germany. Subjects Eleven patients with VPD who had received conventional speech therapy without showing significant improvement. Interventions A four-stage feedback procedure. The patients watched and evaluated their velopharyngeal (VP) valving during speech by an endoscopic image displayed on a video monitor. Two feedback sessions took place for every target sound. Main Outcome Measures Mean occurrence of VP closure during speech sound production on different linguistic levels. Patients’ self-perception was assessed by a questionnaire and speech diary. Results Significant improvement and stability of VP closure was noted. Mean occurrence of VP closure was 5% before therapy, 91% after two biofeedback sessions, and 86% in the follow-up after 6 months. Velopharyngeal dysfunction associated with compensatory articulation proved to be equally well trained as VPD on sounds with good articulatory placement. No significant difference was observed in the degree of improvement between phoneme-specific VPD and generalized VPD. The transfer to the level of words and sentences was successful and showed significant stability. The stability of VP closure for vowels was less than the stability for fricatives and stop sounds. Patients gained improved auditory and kinesthetic self-perception of their articulation. Conclusions Nasopharyngoscopic biofeedback therapy proves to be a quick and effective method to change VPD. It shows stable results and carry-over effects.

Besides prosthetic and indirect, laboratory-produced restorations, the focus of dental therapy is increasingly on restorative measures and direct restorations as minimally invasive treatment concepts. Thus, the use of direct composite restorations with modern restorative materials for the shaping and recontouring of teeth in combination with orthodontic treatment offers a diversified, extensive sphere of application. The aim of the study was to demonstrate applications for direct composite restorations with reference to selected cases. The composites used were hybrid composites, which offer increased abrasion resistance and color stability and are applied incrementally. Special attention was paid to the shape, color and structure of the tooth. The case reports present patients in whom relatively narrow or peg-shaped teeth were built up with composite to correct various tooth size discrepancies or cuspids were recontoured by means of direct composite restorations following orthodontic space closure in cases with missing lateral incisors. Similarly, space closure was achieved using orthodontically repositioned lateral incisors recontoured to resemble central incisors after traumatic loss of upper central incisors. Finally, direct composite restorations were used for retention following completion of orthodontic treatment. Observations over recent years confirm the stability of composites in both form and color, as well as their ability to maintain gingival health. Our case reports demonstrate that, subject to a corresponding indication, recontouring single teeth using direct composite restorations can optimize orthodontic treatment results.

Since the beginning of the 1960's efforts have been made to characterize pathologies in infants' cries. In various pathologies such as brain damage, cleft palate, hydrocephalus, sudden infant death syndrome (SIDS), and many other diseases, special cry characteristics have been reported. The studies performed on the subject (most employing manual time and/or frequency analysis) established the basis for the development of models for cry production and also for the beginning of the development of automatic classification systems. Such a system has been suggested by Cohen and Zmora (Proc. Int. Conf. Dig. SIGPRO, Cappellini, V. and Constantinides, A.G., Eds., Elsevier, Amsterdam, 1984). The system has been proven to be successful in classification of a preliminary database which consisted of hunger and pain cries of healthy full-term infants. Based on this previous work, this paper introduces an automatic classification system for diagnosing various types of infants' cries. The system is based on continuous density hidden Markov models (CD-HMM).

Until now, the literature does not provide an accurate model to predict the future need for orthognathic surgery in prepubertal patients with class III malocclusion. Because not all of these patients are candidates for later surgical correction, patient assessment and selection remain arbitrary with respect to diagnosis and treatment planning. The purpose of the present investigation was to analyze the value of classifying class III children before puberty into patients who can be effectively treated by orthopedic/orthodontic therapy alone and those who require orthognathic surgery. To obtain a robust model, the study design was multicentric (University Orthodontic Departments of Frankfurt, Heidelberg, and Würzburg). A total of 88 patients with class III malocclusion were grouped into orthopedic/orthodontic (n = 65) and surgery patients (n = 23), according to their records after puberty (mean age, 17 years three months). Discriminant analysis (DA) and logistic regression (LogR) were applied to 20 landmarks of the patients' cephalograms before puberty (mean age, nine years eight months) to identify the dentoskeletal variables that provide the best group separation and the best predictability of group membership, respectively. Both models were highly significant (P.001), classifying 93.3% (DA) and 94.3% (LogR) of the patients correctly. The extracted variables were identical for both procedures: Wits appraisal, palatal plane angle, and individualized inclination of the lower incisors. The resulting equation of LogR was individual score = -7.968 - 1.323Wits - 0.363NL-NSL + 0.153[180 - (LI-ML) - (L1-ML(ind))]. We concluded that by means of multivariate statistics, prepubertal children with class III malocclusions may be classified into nonsurgery and surgery patients with high accuracy.

Class III malocclusion is one of the most difficult anomalies to understand. Because not all Class III patients are candidates for surgical correction, patient assessment and selection remain main issues in diagnosis and treatment planning. The purpose of this study was to separate Class III patients who can be properly treated orthodontically from those who require orthognathic surgery. A large sample size was a necessary to obtain a sufficiently robust model. Thus, a multicentric study design was chosen (Orthodontic Departments of the Universities of Frankfurt, Heidelberg, and Wurzburg, Germany). The cephalograms of 175 adult patients with Class III malocclusions were analyzed. The orthodontic group comprised 87 patients, and the surgery group, 88 patients. Twenty linear, proportional, and angular measurements were made. Stepwise discriminant analysis was applied to identify the dentoskeletal variables that best separate the groups. The discriminant function model was highly significant (P

Introduction The aim of this controlled study was to analyze the degree and localization of 3-dimensional (3D) facial asymmetry in adult patients with cleft lip and palate (CLP) compared with a control group and its impact on the visual perception of faces. Methods The degree of 3D asymmetry was analyzed with a novel method without landmarks in 18 adults with complete unilateral CLP and 18 adults without congenital anomalies. Furthermore, the CLP and control faces were rated for appearance, symmetry, and facial expression by 30 participants. Results The results showed that adults with CLP had significantly greater asymmetry in their facial soft tissues compared with the control group. Moreover, the lower face, and particularly the midface, had greater asymmetry in the CLP patients. The perceptual ratings showed that adults with CLP were judged much more negatively than those in the control group. Conclusions With sophisticated 3D analysis, the real morphology of a face can be calculated and asymmetric regions precisely identified. The greatest asymmetry in CLP patients is in the midface. These results underline the importance of symmetry in the perception of faces. In general, the greater the facial asymmetry near the midline of the face, the more negative the evaluation of the face in direct face-to-face interactions.

Introduction The aim of this controlled study was to analyze the degree and localization of 3-dimensional (3D) facial asymmetry in adult patients with cleft lip and palate (CLP) compared with a control group and its impact on the visual perception of faces. Methods The degree of 3D asymmetry was analyzed with a novel method without landmarks in 18 adults with complete unilateral CLP and 18 adults without congenital anomalies. Furthermore, the CLP and control faces were rated for appearance, symmetry, and facial expression by 30 participants. Results The results showed that adults with CLP had significantly greater asymmetry in their facial soft tissues compared with the control group. Moreover, the lower face, and particularly the midface, had greater asymmetry in the CLP patients. The perceptual ratings showed that adults with CLP were judged much more negatively than those in the control group. Conclusions With sophisticated 3D analysis, the real morphology of a face can be calculated and asymmetric regions precisely identified. The greatest asymmetry in CLP patients is in the midface. These results underline the importance of symmetry in the perception of faces. In general, the greater the facial asymmetry near the midline of the face, the more negative the evaluation of the face in direct face-to-face interactions.

In a former study [Wermke et al., Med. Eng. Phys. 24, 501–514 (2002)], an increasing tuning between laryngeal (melody) and pharyngeal (resonance frequencies) activity was demonstrated during pre‐speech development. This tuning was observed unexpectedly early during development in mitigated cries and earliest non‐cry utterances and prepares probably articulation in speech‐like vocalizations of older infants. A new retrospective study supported this assumption by comparing tuning processes in cries and early non‐cry utterances (N=2500) in two groups (low versus high word production performance at 18 months) of term‐born healthy infants (N=20). Additionally, age‐matched comparisons were made in 4 cleft‐lip‐palate‐infants treated with a palatal plate. In order to demonstrate the interaction between melody and resonance control we designed a special graphical representation. The tracking function of the resonance frequencies is displayed synchronously to the melody and its harmonics. Resonance frequencies in pre‐speech utterances are not yet identical to formant bands associated with speech sounds. The results support the existence of an early active tuning and its relation to later speech. This behavior seems to prepare formant tuning in later speech. Medical applications are seen for infants with disturbances of the vocal tract transfer function, e.g., infants with cleft‐lip‐palate. [Work supported by DFG.]