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Purpose: Little is known about the relationships between apathy, depressive symptoms and interdialytic weight gain (IDWG) in patients on chronic hemodialysis. Aim of the present study is to investigate the association between IDWG and symptoms of depression and apathy in hemodialysis patients., Methods: A total of 139 chronic patients of the HD units between January 2020 and December 2021 were included in the present cross-sectional study. IDWG was calculated as the difference between the pre-HD weight and the weight registered after the previous session; the average of the sessions in a month was registered. Apathy Evaluation Scale (AES) was adopted to evaluate apathy. Depression was assessed by Beck Depression Inventory (BDI)., Results: Ninety-three patients had IDWG% ≤ 4 and 46 had an IDWG% > 4. Correlation between IDWG% and BDI as well that between IDWG% and AES were not statistically significant. Median BDI and mean AES did not differ significantly between the groups. In addition, 104 patients had a BDI < 16 and 35 had a BDI ≥ 6. Seventy-five patients had an AES score ≤ 35 and 63 had a AES score > 35. The IDWG (kg) and the IDWG% did not differ significantly between the two groups., Conclusion: IDWG is not associated with symptoms of depression or apathy in hemodialysis patients. Thus, these results may question if the use of behavioral intervention aimed at improving motivation is warranted in the hemodialysis population to reduce the IDWG., (© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)

Advertising uses sounds and dynamic images to provide visual, auditory, and tactile experiences, and to make the audience feel like the protagonist. During COVID-19, companies modified their communication by including pandemic references, but without penalizing multisensorial advertising. This study investigated how dynamic and emotional COVID-19-related advertising affects consumer cognitive and emotional responses. Nineteen participants, divided into two groups, watched three COVID-19-related and three non-COVID-19-related advertisements in two different orders (Order 1: COVID-19 and non-COVID-19; Order 2: non-COVID-19 and COVID-19), while electrophysiological data were collected. EEG showed theta activation in frontal and temporo-central areas when comparing Order 2 to Order 1, interpreted as cognitive control over salient emotional stimuli. An increase in alpha activity in parieto-occipital area was found in Order 2 compared to Order 1, suggesting an index of cognitive engagement. Higher beta activity in frontal area was observed for COVID-19 stimuli in Order 1 compared to Order 2, which can be defined as an indicator of high cognitive impact. Order 1 showed a greater beta activation in parieto-occipital area for non-COVID-19 stimuli compared to Order 2, as an index of reaction for painful images. This work suggests that order of exposure, more than advertising content, affects electrophysiological consumer responses, leading to a primacy effect.

Previous single-brain studies suggested interoception plays a role in interpersonal synchronization. The aim of the present study was to assess the electrophysiological intersubject coherence through electrophysiological (EEG) hyperscanning recording during simple dyadic synchronization tasks when the participants focused on their breath. To this aim, the neural activity of 15 dyads of participants was collected during the execution of a cognitive and motor synchronization task in two distinct IA conditions: focus and no focus on the breath condition. Individuals' EEG frequency bands were recorded through EEG hyperscanning and coherence analysis was performed. Results showed greater EEG coherence was observed for the alpha band in frontopolar brain regions (Fp1, Fp2) and also in central brain regions (C3, C4) within the dyads, during the focus on the breath condition for the motor compared to the cognitive synchronization task; during the same experimental condition, delta and theta band showed augmented inter-individual coherence in the frontal region (Fz) and central areas (C3, C4). To conclude, the current hyperscanning study highlights how the manipulation of the interoceptive focus (obtained through the focus on the breath) strengthens the manifestation of the EEG markers of interpersonal tuning during a motor synchronization task in specific brain areas., (© 2023. The Author(s).)

We propose a hyperscanning research design, where electroencephalographic (EEG) data were collected on an instructor and teams of learners. We compared neurophysiological measures within the frequency domain (delta, theta, alpha, and beta EEG bands) in the two conditions: face-to-face and remote settings. Data collection was carried out using wearable EEG systems. Conversational analysis was previously applied to detect comparable EEG time blocks and semantic topics. The digitalization of training can be considered a challenge but also a chance for organizations. However, if not carefully addressed, it might constitute a criticality. Limited research explored how remote, as opposed to face-to-face, training affects cognitive, (such as memory and attention), affective, and social processes in workgroups. Data showed an alpha desynchronization and, conversely, a theta and beta synchronization for the face-to-face condition. Moreover, trainees showed different patterns for beta power depending on the setting condition, with significantly increased power spectral density (PSD) in the face-to-face condition. These results highlight the relevance of neurophysiological measures in testing the e-learning process, in relation to the emotional engagement, memory encoding, and attentional processing.

The effect of explicit interoception manipulation on electrophysiological (EEG) patterns concurrent with an interpersonal motor synchronization task with a social purpose was investigated in this study. Thirty healthy individuals executed a task involving behavioral motor synchronization with a social framing in both focus (conceived as the focus on the breath for a specific time interval) and no focus conditions. During the task, a 15 active electrodes electroencephalogram was used to record the following frequency bands (delta, theta, alpha, and beta band) from the frontal, temporo-central, and parieto-occipital regions of interest (ROIs). According to the results, for all the frequency bands significant higher mean values were found in the focus compared to no focus condition in the parieto-occipital ROI. On the whole, the current work conveys that when a motor synchronization task is executed and the person concurrently pays attention to his/her body correlates, EEG brain activity is empowered and boosted in posterior areas at the basis of attention to visceral signals, but also interpersonal action coordination. This evidence could have potentially interesting implications because it suggests the importance of modern breath-work during all conditions that require a social motor joint task, such as physiotherapy exercises or synchronized sports.

Empathy is a phenomenon that brings together both emotions and an understanding of another person. Recent studies have disentangled the mechanisms of empathy into emotional and cognitive aspects. Event-related potential (ERP) studies suggest that emotional empathy is related to the modulation of the amplitude of early ERPs, and cognitive empathy is linked to later ERPs. In the current study, we examined the influences of facial attractiveness on empathic response and the effect of cognitive strategies with setting the participants' attention to attractiveness or pain. Participants (N= 19) viewed photos of physically attractive and unattractive men and women receiving painful stimulation. The amplitude of the N2 component measured at the frontal regions was more negative in painful stimulation compared to the non-painful, but only for attractive faces. There were no differences between painful and non-painful stimulation for unattractive faces. The amplitude of the P3 measured at the central-parietal region component was more positive in the painful condition compared to the non-painful one, but only when participants performed a pain judgment task. There were no differences in the attractiveness judgment task. This study showed that the attractiveness of a model and drawing the participants' attention to pain constitute an essential modulator of pain empathy., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflict of interest.

To date, neuroscientific literature on consumption patterns of specific categories of consumers, such as people with disability, is still scarce. This study explored the implicit emotional consumer experience of visually impaired (VI) consumers in-store. A group of VI and a control group explored three different product shelves and manipulated target products during a real supermarket shopping experience. Autonomic (SCL, skin conductance level; SCR, skin conductance response; HR, heart rate; PVA, pulse volume amplitude; BVP, blood volume pulse), behavioural and self-report data were collected in relation to three phases of the in-store shopping experience: (i) identification of a product (recognition accuracy, ACC, and reaction times, RTs); (ii) style of product purchase (predominant sense used for shelf exploration, store spatial representation, and ability to orientate themselves); (iii) consumers experience itself, underlying their emotional experience. In the VI group, higher levels of disorientation, difficulty in finding products, and repeating the route independently were discovered. ACC and RTs also varied by product type. VI also showed significantly higher PVA values compared to the control. For some specific categories (pasta category), PVA correlates negatively with time to recognition and positively with simplicity in finding products in the entire sample. In conclusion, VI emotional and cognitive experience of grocery shopping as stressful and frustrating and has a greater cognitive investment, which is mirrored by the activation of a larger autonomic response compared to the control group. Nevertheless, VI ability to search and recognise a specific product is not so different from people without visual impairment.

Little is known about how the modulation of the interoceptive focus impacts the neural correlates of high-level social processes, such as synchronization mechanisms. Therefore, the current study aims to explore the intraindividual electrophysiological (EEG) patterns induced by the interoceptive focus on breath when performing cognitive and motor tasks requiring interpersonal synchronization. A sample of 28 healthy caucasian adults was recruited and asked to perform two tasks requiring interpersonal synchronization during two distinct conditions: while focusing on the breath or without the focus on the breath. EEG frequency bands (delta, theta, alpha, and beta band) were recorded from the frontal, temporo-central, and parieto-occipital regions of interest. Significant results were observed for the delta and alpha bands. Notably, higher mean delta values and alpha desynchronization were observed in the temporo-central area during the focus on the breath condition when performing the motor compared to the cognitive synchronization task. Taken together these results could be interpreted considering the functional meaning of delta and alpha band in relation to motor synchronization. Indeed, motor delta oscillations shape the dynamics of motor behaviors and motor neural processes, while alpha band attenuation was previously observed during generation, observation, and imagery of movement and is considered to reflect cortical motor activity and action-perception coupling. Overall, the research shows that an EEG delta-alpha pattern emerges in the temporo-central areas at the intra-individual level, indicating the attention to visceral signals, particularly during interpersonal motor synchrony., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Angioletti and Balconi.)

Introduction: This study explores the link between fatigue and apathy in patients on chronic hemodialysis (HD)., Methods: One hundred thirty-nine chronic HD patients underwent the assessment of fatigue, apathy, depression, and their functional status, with the fatigue severity scale (FSS), the Apathy Evaluation Scale (AES), the beck depression inventory (BDI), the activity of daily living (ADL), and instrumental activity of daily living (IADL)., Results: Patients with high FSS had a significantly lower ADL and IADL score, higher BDI, Charlson Comorbidity Index, and AES score, and lower serum levels of creatinine, compared to low FSS patients. FSS was highly correlated with the AES, as well as with the BDI and the AES correlates with the BDI. At multiple regression analyses, only apathy and IADL were independent predictor variables of fatigue in HD population., Conclusion: Future longitudinal studies could determine if apathy is a causative factor for fatigue manifestation and development in HD patients., (© 2021 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.)

So far, little is known about how conscious attention to internal body signals, that is, interoception, affects the synchronization with another person, a necessary or required social process that promotes affiliations and cooperation during daily joint social interactions. The effect of explicit interoceptive attentiveness (IA) modulation, conceived as the focus on the breath for a given time interval, on electrophysiological (EEG) correlates during an interpersonal motor task compared with a cognitive synchronization task was investigated in this study. A total of 28 healthy participants performed a motor and a cognitive synchronization task during the focus and no-focus breath conditions. During the tasks, frequency bands (delta, theta, alpha, and beta bands) from the frontal, temporo-central, and parieto-occipital regions of interest (ROIs) were acquired. According to the results, significantly higher delta and theta power were found in the focus condition in the frontal ROI during the execution of the motor than the cognitive synchronization task. Moreover, in the same experimental condition, delta and beta band power increased in the temporo-central ROI. The current study suggested two main patterns of frequency band modulation during the execution of a motor compared with the cognitive synchronization task while a person is focusing the attention on one's breath. This study can be considered as the first attempt to classify the different effects of interoceptive manipulation on motor and cognitive synchronization tasks using neurophysiological measures., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Angioletti and Balconi.)

This research explored the effect of explicit Interoceptive Attentiveness (IA) manipulation on hemodynamic brain correlates during a task involving interpersonal motor coordination framed with a social goal. Participants performed a task requiring interpersonal movement synchrony with and without a social framing in both explicit IA and control conditions. Functional Near-Infrared Spectroscopy (fNIRS) was used to record oxygenated (O2Hb) and deoxygenated hemoglobin (HHb) changes during the tasks. According to the results, the prefrontal cortex (PFC), which is involved in high-order social cognition and interpersonal relations processing, was more responsive when inducing the explicit focus (IA) on the breath during the socially framed motor task requiring synchronization, as indicated by increased O2Hb. In the absence of a broader social frame, this effect was not significant for the motor task. Overall, the present study suggests that when a joint task is performed and the individual focuses on his/her physiological body reactions, the brain hemodynamic correlates are "boosted" in neuroanatomical regions that support sustained attention, reorientation of attention, social responsiveness, and synchronization. Furthermore, the PFC responds significantly more as the person consciously focuses on physiological interoceptive correlates and performs a motor task requiring synchronization, particularly when the task is socially framed., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Angioletti and Balconi.)

Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Past research showed that the ability to focus on one's internal states (e.g., interoceptive ability) positively correlates with the self-regulation of behavior in situations that are accompanied by somatic and/or physiological changes, such as emotions, physical workload, and decision-making. The analysis of moral oriented decision-making can be the first step for better understanding the legal reasoning carried on by the main players in the field, as lawyers are. For this reason, this study investigated the influence of the decision context and interoceptive manipulation on the moral decision-making process in the legal field gathering the responses of two groups of lawyers. A total of 20 lawyers were randomly divided into an experimental group (EXP), which was explicitly required to focus the attention on its interoceptive correlates, and a control group (CON), which only received the general instruction to perform the task. Both groups underwent a modified version of the Ultimatum Game (UG), where are presented three different moral conditions (professional, company, and social) and three different offers (fair, unfair, and equal). Results highlighted a significant increase of Acceptance Rate (AR) in those offers that should be considered more equal than fair or unfair ones, associated with a general increase of Reaction Times (RTs) in the equal offers. Furthermore, the interoceptive manipulation oriented the Lawyers toward a more self-centered decision. This study shows how individual, situational, contextual, and interoceptive factors may influence the moral decision-making of lawyers. Future research in the so-called Neurolaw field is needed to replicate and expand current findings., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Angioletti, Tormen and Balconi.)

Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

The COVID-19 pandemic has prompted the production of a vast amount of COVID-19-themed brand commercials, in an attempt to exploit the salience of the topic to reach more effectively the consumers. However, the literature has produced conflicting findings of the effectiveness of negative emotional contents in advertisings. The present study aims at exploring the effect of COVID-19-related contents on the hemodynamic brain correlates of the consumer approach or avoidance motivation. Twenty Italian participants were randomly assigned to two different groups that watched COVID-19-related or non-COVID-19-related commercials. The hemodynamic response [oxygenated (O 2 Hb) and deoxygenated hemoglobin modulations] within the left and right prefrontal cortices (PFC) was monitored with Functional Near-Infrared Spectroscopy (fNIRS) while brand commercials were presented, as the prefrontal lateralization was shown to be indicative of the attitude toward the brand and of the approach-avoidance motivation. First, the findings showed that the COVID-19-related contents were able to prompt emotional processing within the PFC to a higher extent compared to contents non-related to COVID-19. Moreover, the single-channel analysis revealed increased O 2 Hb activity of the left dorsolateral PFC compared to the left pars triangularis Broca's area in the group of participants that watched the COVID-19-related commercials, suggesting that the commercials may have driven participants to dedicate more attention toward the processing of the emotional components compared to the semantic meaning conveyed by the ad. To conclude, despite expressing unpleasant emotions, commercials referring to the highly emotional pandemic experience may benefit the advertising efficacy, increasing the capability to reach customers., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Balconi, Sansone and Angioletti.)

Aim: This study explores interoceptive attentiveness (IA) influence on autonomic reactivity related to pain and self-regulation during situations evoking physiological mirroring for pain. Methods: 20 participants observed face/hand, painful/non-painful stimuli in an individual versus social condition while the autonomic response was measured [Electrodermal activity, Pulse Volume Amplitude (PVA), and Heart Rate (HR)] was measured. The sample was divided into experimental (EXP) subjects, required to focus on their interoceptive correlates while observing the stimuli, and the control (CNT) group. HR inter-beat interval (IBI), and HR Variability (HRV) were calculated. Results: Results showed high accuracy to painful and non-painful stimuli recognition. Regarding autonomic indices, higher PVA values were detected for hand painful versus non-painful stimuli, whereas for the EXP group a significant activation of IBI was found for face painful vs non-painful stimuli. Conclusion: In the context of observation of pain in others, PVA and IBI could be respectively markers of mirroring mechanisms and autonomic self-regulation mediated by IA.

Currently, there is little understanding of how interoceptive attentiveness (IA) affects brain responses during synchronized cognitive or motor tasks. This pilot study explored the effect of explicit IA manipulation on hemodynamic correlates of simple cognitive tasks implying linguistic or motor synchronization. Eighteen healthy participants completed two linguistic and motor synchronization tasks during explicit IA and control conditions while oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin variations were recorded by functional Near-Infrared Spectroscopy (fNIRS). The findings suggested that the brain regions associated with sustained attention, such as the right prefrontal cortex (PFC), were more involved when an explicit focus on the breath was induced during the cognitive linguistic task requiring synchronization with a partner, as indicated by increased O2Hb. Interestingly, this effect was not significant for the motor task. In conclusion, for the first time, this pilot research found increased activity in neuroanatomical regions that promote sustained attention, attention reorientation, and synchronization when a joint task is carried out and the person is focusing on their physiological body reactions. Moreover, the results suggested that the benefits of conscious concentration on physiological interoceptive correlates while executing a task demanding synchronization, particularly verbal alignment, may be related to the right PFC.

This research explored how the manipulation of interoceptive attentiveness (IA) can influence the frontal (dorsolateral prefrontal cortex (DLPFC) and somatosensory cortices) activity associated with the emotional regulation and sensory response of observing pain in others. 20 individuals were asked to observe face versus hand, painful/non-painful stimuli in an individual versus social condition while brain hemodynamic response (oxygenated (O2Hb) and deoxygenated hemoglobin (HHb) components) was measured via functional Near-Infrared Spectroscopy (fNIRS). Images represented either a single person (individual condition) or two persons in social interaction (social condition) both for the pain and body part set of stimuli. The participants were split into experimental (EXP) and control (CNT) groups, with the EXP explicitly required to concentrate on its interoceptive correlates while observing the stimuli. Quantitative statistical analyses were applied to both oxy- and deoxy-Hb data. Firstly, significantly higher brain responsiveness was detected for pain in comparison to no-pain stimuli in the individual condition. Secondly, a left/right hemispheric lateralization was found for the individual and social condition, respectively, in both groups. Besides, both groups showed higher DLPFC activation for face stimuli presented in the individual condition compared to hand stimuli in the social condition. However, face stimuli activation prevailed for the EXP group, suggesting the IA phenomenon has certain features, namely it manifests itself in the individual condition and for pain stimuli. We can conclude that IA promoted the recruitment of internal adaptive regulatory strategies by engaging both DLPFC and somatosensory regions towards emotionally relevant stimuli., Competing Interests: The authors declare no conflict of interest., (© 2022 The Author(s). Published by IMR Press.)

Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Enhancing the embodiment of artificial limbs-the individuals' feeling that a virtual or robotic limb is integrated in their own body scheme-is an impactful strategy for improving prosthetic technology acceptance and human-machine interaction. Most studies so far focused on visuo-tactile strategies to empower the embodiment processes. However, novel approaches could emerge from self-regulation techniques able to change the psychophysiological conditions of an individual. Accordingly, this pilot study investigates the effects of a self-regulated breathing exercise on the processes of body ownership underlying the embodiment of a virtual right hand within a Spatially Augmented Respiratory Biofeedback (SARB) setting. This investigation also aims at evaluating the feasibility of the breathing exercise enabled by a low-cost SARB implementation designed for upcoming remote studies (a need emerged during the COVID-19 pandemic). Twenty-two subjects without impairments, and two transradial prosthesis users for a preparatory test, were asked (in each condition of a within-group design) to maintain a normal (about 14 breaths/min) or slow (about 6 breaths/min) respiratory rate to keep a static virtual right hand "visible" on a screen. Meanwhile, a computer-generated sphere moved from left to right toward the virtual hand during each trial (1 min) of 16. If the participant's breathing rate was within the target (slow or normal) range, a visuo-tactile event was triggered by the sphere passing under the virtual hand (the subjects observed it shaking while they perceived a vibratory feedback generated by a smartphone). Our results-mainly based on questionnaire scores and proprioceptive drift-highlight that the slow breathing condition induced higher embodiment than the normal one. This preliminary study reveals the feasibility and potential of a novel psychophysiological training strategy to enhance the embodiment of artificial limbs. Future studies are needed to further investigate mechanisms, efficacy and generalizability of the SARB techniques in training a bionic limb embodiment., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Barresi, Marinelli, Caserta, de Zambotti, Tessadori, Angioletti, Boccardo, Freddolini, Mazzanti, Deshpande, Frigo, Balconi, Gruppioni, Laffranchi and De Michieli.)

The present research explored electrophysiological activity (EEG) related to problematic internet use (PIU) vulnerability in a nonclinical population. Vulnerability to PIU was assessed through internet addiction test (IAT) in a sample of 23 participants. Moreover, they underwent a behavioral Iowa gambling task (IGT) for testing decision-making functioning and N2 event-related potentials (ERPs) component was monitored during an attentional inhibitory Go/NoGo task performance with addiction-related background pictures (videogames, online gambling, and neutral stimuli). IAT measure positively correlated with both IGT index and N2 variation at the Go/NoGo task. High-IAT young participants showed specific responses to internet addiction-related cues (pictures representing online gambling) in terms of ERPs amplitude of N2pc for Go trials in Pz. Findings suggested an early attentional facilitation effect for specific addiction-related stimuli, online gambling-related stimuli, suggesting a selective attention bias for salient stimuli in this population. While higher levels of IAT do not seem to correspond to a deficit in decision-making abilities, the selective attention mechanisms show to be partially biased in response to the salience of external cues.

Objective: We investigated whether the mid-term impact (1 week posttraining) of a "combined cognitive rehabilitation (CRP)/transcranial direct current stimulation (tDCS) program" on the performance of a Go/No-go task was enhanced compared with isolated CRP and whether it varied according to the stimulation site (right inferior frontal gyrus [rIFG] vs right dorsolateral prefrontal cortex [rDLPFC])., Methods: A total of 150 healthy participants were assigned to (1) an Inhibition Training (IT) group, (2) a group receiving active tDCS over the rIFG in combination with IT (IT + IF), (3) a group receiving active tDCS over the rDLPFC in combination with IT (IT + DL), (4) a group receiving IT with sham tDCS (ITsham), and (5) a No-Training (NT) group to control for test-retest effects. Each group undertook 3 sessions of a Go/No-go task concomitant with the recording of event-related potentials (T0, before training; T1, at the end of a 4-day training session [20 minutes each day]; T2, 1 week after T1)., Results: With the exception of the NT participants, all the groups exhibited improved performances at T2. The IT + DL group exhibited the best improvement profile, indexed by faster response times (RTs) (T0 > T1 = T2), with a reduced rate of errors at the posttraining sessions compared with both T0 and T1. This "inhibitory learning effect" was neurophysiologically indexed by shorter No-go N2d latencies and enhanced No-go P3d amplitudes., Conclusion: CRP combined with active tDCS over the rDLPFC appears to be optimal for boosting long-term (one week) inhibitory skills as it induced specific and robust neural changes.

Objective: This research demonstrates that interoceptive attentiveness (IA) can modulate cortical oscillations related to the emotional and cognitive representations of observing pain in others., Methods: Twenty participants were required to observe painful/nonpainful stimuli in an individual versus the interactive condition during the recording of the electroencephalogram. The sample was divided into experimental (EXP) and control (CTR) groups, and the EXP group was explicitly required to direct the attention on its interoceptive correlates while observing the stimuli., Results: Mixed repeated measures, analyses of variance, were applied to each EEG frequency band. Significant findings were obtained mainly for theta and beta bands for the two groups. A hemispheric lateralisation effect was found, with right lateralisation of the theta band for the EXP group when observing painful stimuli and enhanced left activation of theta and beta bands for the CTR group when observing nonpainful stimuli. For both groups, frontal cortical regions were significantly sensitive to social scenarios, while posterior parietal activation was found for stimuli depicting the individual condition., Conclusions: The results suggest that IA might enhance the emotional representation of painful stimuli, highlighting their negative and unpleasant features in the EXP group, while the attention of the CTR group was mainly drawn to nonpainful stimuli in social and individual conditions, with a positive valence. The role of frontal regions in the processing of social stimuli through social cognition, inducing emotional mirroring and requiring deeper analysis of the social context, was underlined. We propose that IA could be trained for promoting emotion regulation and empathic response., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2021 Michela Balconi and Laura Angioletti.)

To gain a deeper understanding of consumers' brain responses during a real-time in-store exploration could help retailers to get much closer to costumers' experience. To our knowledge, this is the first time the specific role of touch has been investigated by means of a neuroscientific approach during consumer in-store experience within the field of sensory marketing. This study explores the presence of distinct cortical brain oscillations in consumers' brain while navigating a store that provides a high level of sensory arousal and being allowed or not to touch products. A 16-channel wireless electroencephalogram (EEG) was applied to 23 healthy participants (mean age = 24.57 years, SD = 3.54), with interest in cosmetics but naive about the store explored. Subjects were assigned to two experimental conditions based on the chance of touching or not touching the products. Cortical oscillations were explored by means of power spectral analysis of the following frequency bands: delta, theta, alpha, and beta. Results highlighted the presence of delta, theta, and beta bands within the frontal brain regions during both sensory conditions. The absence of touch was experienced as a lack of perception that needs cognitive control, as reflected by Delta and Theta band left activation, whereas a right increase of Beta band for touch condition was associated with sustained awareness on the sensory experience. Overall, EEG cortical oscillations' functional meaning could help highlight the neurophysiological implicit responses to tactile conditions and the importance of touch integration in consumers' experience., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Balconi, Venturella, Sebastiani and Angioletti.)

Empathy for pain is at the basis of altruistic behaviors and is known to be modulated by variables such as group membership, pleasantness or unpleasantness of situations and social relationships. Also, face attractiveness and aesthetic judgment might play a role when observing a person in painful conditions, by increasing individuals' empathic responsiveness. Indeed, physical attractiveness can modify both the perception of the face itself and its reception in a social context. In the present study, we aimed to assess cortical activity when attention is focused on the aesthetic features of an individual showing painful feelings. Brain activity (optical imaging: functional near-infrared spectroscopy, fNIRS), considered in its hemodynamic components (oxygenated [oxy-Hb] and deoxygenated hemoglobin [deoxy-Hb]) was monitored when 22 subjects (M age  = 24.9; SD = 3.6) observed faces (attractive; unattractive) that received painful stimulations (pain; no pain) and were asked to judge the attractiveness and pain condition of the face. Specifically, we targeted the left and right inferior frontal gyrus (IFG), sensory cortex, and temporo-parietal junction (TPJ). Analyses revealed significant lower oxy-Hb levels in left IFG compared to right hemispheric channels when asking participants to rate faces attractiveness independently from the stimulus features. Besides, lower levels of deoxy-Hb were detected in the right TPJ for unattractive faces compared to attractive faces. Overall, present findings highlighted that the formulation of an aesthetic judgment and face attractiveness plays a relevant role in empathic concerns and this seems to be able to overlay painful appraisal.

Recently, it has been demonstrated that chronic inflammation could have a role on fatigue onset in chronic hemodialysis (HD). Research on neuro-immune interactions highlighted that an alteration of basal ganglia functioning, secondary to chronic inflammation, may translate in a reduced motivation and altered reward processes in chronic diseases. This study investigated a possible correlation between fatigue severity and reward mechanisms, that regulate motivational dispositions, in HD patients. Evaluation scales were administered to ninety-four patients on HD (54 Male, 40 Female; Md age  = 67±26.5; Dialytic Md age in years = 4±6.3. Fatigue was assessed by using Fatigue Severity Scale (FSS). Behavioural Inhibition System (BIS) and Behavioural Activation System (BAS) Scale was administered to investigate approach/avoidance behaviours. Anxiety and depression were measured by State-Trait Anxiety Inventory (STAI-Y) and Beck Depression Inventory (BDI-II). Results show that the distribution of HD patients for FSS score did not show a normal pattern. FSS score was significantly higher in patients with high BIS Z-score than in patients with low and medium BIS Z-score. BDI score and STAI-Y scores were similar among BIS Z-score groups of patients. Findings suggest that in patients on chronic hemodialysis there is a correlation between fatigue severity symptoms and motivational disposition mechanisms that predispose to action inhibition.

Home automation brings together technology, engineering, and user experience (UX). Within this framework, even neuroscience could be a valuable discipline to explore UX. For the first time, in the present work, some distinguishing effects of domotics on users' cognitive and emotional behavior are highlighted by using the neuroscientific approach. In order to define possible effects of a smart home system (SHS) on UX, a neuroscientific multimethodology was adopted with the purpose of recording and confronting the neural activity (electroencephalography, EEG) and autonomic system responses of 19 individuals during a resting state (RS) baseline and the exploration of five different tech-interaction areas in a domotic environment. EEG findings showed a generalized neural activation reflected by alpha band activity while participants were exploring the tech areas confronted with the RS. The delta band was mainly present in temporo-central compared to frontal and parieto-occipital areas and was interpreted as a higher emotional activation related to the whole UX. This effect was found for the sixth tech-interaction area (i.e., bedroom) compared to the RS, and it is supposed to represent an enhanced emotional response and integration processing toward a higher multisensory interactive area. Regarding autonomic activity, an increase in heart rate (HR) was found for the bedroom area compared to the RS, thus showing a specific effect on physiological indices in this engaging tech area. The present research constitutes the first attempt to understand the user responsiveness to SHS, in terms of cognitive and emotional engagement, by adopting a neuroscientific perspective. Some high-value benefits derived from this approach will be described in light of the neurophysiological results., (Copyright © 2020 Angioletti, Cassioli and Balconi.)

Increased attention and lower stress levels are associated with more functional and safe driving behavior, since they contribute to reduce distractibility and risk-taking at the wheel. Previous neuroscience research highlighted that NeuroFeedback (NF) training mediated by wearable devices could be effective in terms of neurocognitive strengthening and attention regulation with a direct effect on driving attentional performance. Thus, this research aims to test the effectiveness of a NF protocol on a sample of drivers, to observe its impact on attentional skills and psychophysiological levels of stress involved in driving behavior. 50 participants were randomly assigned to the experimental and active control group. The experimental condition consisted of a 21-day mindfulness NF training with incremental duration sessions. A pre- ( t 0) and post-treatment ( t 1) assessment included behavioral, psychometric, neuropsychological, and psychophysiological autonomic measures. Specifically, the Driver Behavior Questionnaire (DBQ) and the Active Box (AB) device were used to evaluate the everyday driving behavior. Results underlined an improvement in driving behavior performance and a decrease of violations at the wheel of the experimental group (EXPg) at t 1 measured, respectively by AB and DBQ. About the autonomic and neuropsychological measure, an increase in heart rate (HR) and an increased accuracy at the Stroop Task were detected: a specific increase of Stroop-related HR was found for the EXPg at t 1. Also, reduced reaction times were found in the Multiple Features Target Cancellation for the EXPg at t 1. Overall, the EXPg displayed a physiological, behavioral and neuropsychological increased efficiency related to attention as well as a driving-related behavioral improvement after NF training., (Copyright © 2019 Balconi, Crivelli and Angioletti.)

According to the somatic marker hypothesis, autonomic measures and arousal modulation can reveal a difference in subgroups of patients developing impaired decision-making because of addictions. Previously, pathological gambling (PG) and Parkinson's disease (PD) have been associated with differential arousal levels during gambling behavior. However, no research considered the specific autonomic responses of Parkinson's disease patients with pathological gambling and with a previous history of gambling. Thus, this study investigated skin conductance responses (SCRs), skin conductance level (SCL) and heart rate (HR) during the Iowa Gambling Task (IGT) in two groups of PD patients with gambling disorder, active (PD Gamblers; n = 14) or remitted (PD Non-Gamblers; n = 13) and a control group of patients with Parkinson's disease only (n = 13). Anticipatory autonomic responses to disadvantageous decks and advantageous decks during the Iowa Gambling Task were measured for each participant. The PD Gamblers group performed worse than the PD Non-Gamblers and the control groups at the IGT task and exhibited lower SCRs, SCL, and HR during the decision-making processing of cards belonging to disadvantageous decks. The role of autonomic and behavioral measures was considered., (© 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)

Background: Nowadays there is a growing interest in exploring causes of fatigue symptoms and the possible linked aspects in patients with Chronic Kidney Disease (CKD) receiving hemodialysis (HD) treatment. Inflammatory processes were demonstrated to influence motivational systems functioning in chronic conditions. However, there is a lack of connection between quantitative motivational systems measure and patients self-report motivational and fatigue issue. Thus, the aim of this study was to identify an association between HD patients reward mechanisms, fatigue severity and psychosocial variables emerging from semi-structured interviews., Methods: Interviews were held for a sample of ninety-four patients (54 males, 40 females; M age  = 62.98 ± 17.94; dialytic mean age in months = 76.55 ± 84.89) receiving chronic HD treatment and consequently analyzed by means of quantitative and qualitative analysis. Behavioral motivation systems reflecting inhibition/approach tendency to rewards were measured by Behavioral Inhibition/Activation System (BIS/BAS) scale and the fatigue severity experienced by HD patients was measured with the Fatigue Severity Scale. Scale results were correlated to psychosocial variables and topics derived from the semi-structured interviews., Results: Findings highlight the presence of two effects: one related to the Behavioral Activation System (BAS) as a protective factor against the HD treatment pervasive consequences; the other one deals with the self-reported levels of fatigue that seemed to significantly interfere with patients' daily life, as a function of gender., Conclusions: Such results encourage the use of a mixed method approach to understand the complexity of the subjective experience of patients' facing chronic disease and treatments.

Psychopathological components, such as reward sensitivity and impulsivity, and dopaminergic treatment are crucial characteristics related to the development of Pathological Gambling (PG) in Parkinson's Disease (PD). The aim of the present study is to investigate the differences in decision-making in PD patients with or without PG considering both neurophysiological and behavioral aspects. The IOWA Gambling Task (IGT) and electroencephalographic (EEG) activity were considered to elucidate the decision and post-feedback processes in PG. The sample included fifty-two PD patients, divided in three groups: 17 PD patients with active gambling behavior (PD Gamblers, PDG); 15 PD patients who remitted from PG (PD Non-Gamblers, PDNG); and a Control Group (CG) composed by 20 patients with PD only. EEG and IGT performance were recorded during decision and post-feedback phase. Results showed worse performance and an increase of the low frequency bands in the frontal area for the PDG group compared to the other two groups. In addition, higher BAS (Behavioral Activation System) and BIS-11 (Barratt Impulsiveness Scale) personality components were correlated to groups' behavioral response. These results show an anomalous behavioral (IGT) and cortical response of PDG patients related to their inability to use adequate control mechanisms during a decision-making task where reward mechanisms (BAS) and impulsivity (BIS-11) are relevant., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Fatigue is an incapacitating symptom for patients on chronic hemodialysis treatment. This study explored the relationship between hemodialysis patients' subjective experience and motivation. The investigation of patients' narratives and fatigue-related factors was performed by holding semi-structured interviews with 31 hemodialysis patients. Fatigue Severity Scale and Behavioral Inhibition/Activation System questionnaire were used to assess fatigue severity and motivational mechanisms. Results showed significant differences in the use of specific topics and words (such as "family," "to manage," "dialysis," "psychological issues") depending on high, medium, and low Behavioral Inhibition System, Behavioral Activation System, and Fatigue Severity Scale scores, indicating that hemodialysis patients' narratives contain keywords related to the motivational sphere., Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Previous work showed that, when we interact with other people, an alignment of psychophysiological measures occur as a clue about the intensity of the social interaction. Available evidence highlighted increase autonomic synchrony, known as physiological linkage, during intense dyadic situations, like conflictual conversations within romantic couples, friends, or therapeutic settings. Starting from the idea that higher physiological linkage could support better performance and be correlated with approach attitudes (Behavioral Activation System, BAS), in the present study a conflictual situation was proposed by making subjects compete during an attentional task and stressing the importance to win as a measure of future professional success. Autonomic activity (electrodermal: skin conductance level and response: SCL, SCR; and cardiovascular indices: heart rate: HR) was recorded during the task, where subjects received trial-related feedbacks on their performance, and an average score halfway which (fictitiously) assessed their position in terms of accuracy and reaction times with respect to the opponent. In parallel, behavioral inhibition and activation have been assessed by means of the Behavioral Inhibition/Activation System Questionnaire (BIS/BAS). 32 subjects coupled in 16 dyads were recruited. Intra-subject analyses revealed that, after the general evaluation assessing a winning condition, the behavioral performance improved and the electrodermal response increased. Also, correlational analyses showed a relation between BAS, and specifically BAS reward, with SCR. Inter-subject analyses showed higher synchrony in SCR and HR after the feedback. Such results confirm the increased synchronic effect after a highly conflictual condition, and the presence of a relation between subjective performance, approach-related motivations, and physiological linkage.

Background: Pathological gambling (PG) in Parkinson's disease (PD) manifests as a persistent and uncontrollable gambling behavior, characterized by dysfunctional decision-making and emotional impairment related to high-risk decisions., Objective: The aim of this study was to explore the relationship between personality traits and prefrontal cortex activity in PD patients with or without PG., Methods: Thus, hemodynamic cortical activity measured by functional near-infrared spectroscopy (fNIRS) and Iowa Gambling Task (IGT) performance were recorded in forty-six PD patients, divided into three groups according to their gambling status: PD patients with active gambling behavior (PDG); PD patients who remitted from PG (PDNG); and a control group (CG) composed by patients with PD only., Results: Results indicates that gambling behavior in PD patients is strongly predictive of dysfunctional cognitive strategy; affecting anomalous cortical response with a left hemispheric unbalance in dorsal areas; and it is related to more reward sensitivity than impulsivity personality components., Conclusions: PDG patients differed from PDNG and CG from both behavioral and brain response to decision-making. Overall, these effects confirm a pathological condition related to cognitive and emotional aspects which makes the patients with PGD victims of their dysfunctional behavior.

Previous research highlighted that during social interactions people shape each other's emotional states by resonance mechanisms and synchronized autonomic patterns. Starting from the idea that joint actions create shared emotional experiences, in the present study a social bond was experimentally induced by making subjects cooperate with each other. Participants' autonomic system activity (electrodermal: skin conductance level and response: SCL, SCR; cardiovascular indices: heart rate: HR) was continuously monitored during an attentional couple game. The cooperative motivation was induced by presenting feedback which reinforced the positive outcomes of the intersubjective exchange. 24 participants coupled in 12 dyads were recruited. Intrasubject analyses revealed higher HR in the first part of the task, connoted by increased cognitive demand and arousing social dynamic, while intersubject analysis showed increased synchrony in electrodermal activity after the feedback. Such results encourage the use of hyperscanning techniques to assess emotional coupling in ecological and real-time paradigms.

Forty consecutive patients with age-related macular degeneration and a choroidal neovascular membrane in the center of the macula were treated by dye laser photocoagulation. After a mean 24 month follow-up period, 21 patients (52.5%) remained stable or improved in vision. Of 21 patients with initial visual acuity of 20/100 or better, 11 patients (52%) remained 20/100 or better. In the control group only four patients (25%) remained stable or improved, and only two (15%) remained 20/100 or better. The theoretical and clinical advantages of the indirect laser treatment of subfoveal choroidal neovascular membranes in age-related macular degeneration are discussed.