51. Gold nanoparticles: New routes across old boundaries
- Author
-
Pankaj Kumar Singh, Gurmandeep Kaur, Rajesh Kumar, Rubiya Khursheed, Ankit Kumar Yadav, V.V.S. Narayana Reddy Karri, Dipanjoy Ghosh, Ankit Awasthi, Kamal Dua, Rajan Kumar, Monica Gulati, K. Gowthamarajan, Ayinkamiye Clarisse, Ravichandran Mahalingam, Sachin Kumar Singh, Yogita Kumari, Bhupinder Kapoor, and Omji Porwal
- Subjects
Computer science ,Size dependent ,Nanotechnology ,02 engineering and technology ,Surfaces and Interfaces ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Diagnostic tools ,Site specificity ,Biocompatible material ,01 natural sciences ,0104 chemical sciences ,Colloid and Surface Chemistry ,Colloidal gold ,Physical and Theoretical Chemistry ,0210 nano-technology ,Metal nanoparticles ,Drug carrier ,Site of action - Abstract
In recent years, gold nanoparticles have emerged as unique non-invasive drug carriers for targeting drugs to their site of action. Their site specificity has helped in increasing drugs' efficacy at lower dose as well as reduction in their side effects. Moreover, their excellent optical properties and small size offer their utilization as diagnostic tools to diagnose tumors as well as other diseases. This review focuses on various approaches that have been used in last several years for preparation of gold nanoparticles, their characterization techniques and theranostic applications. Their toxicity related aspects are also highlighted. Gold nanoparticles are useful as theranostic agents, owing to their small size, biocompatible nature, size dependent physical, chemical and optical properties etc. However, the challenges associated with these nanoparticles such as scale up, cost, low drug payload, toxicity and stability have been the major impediments in their commercialization. The review looks into all these critical issues and identifies the possibilities to overcome these challenges for successful positioning of metallic nanoparticles in market.
- Published
- 2019
- Full Text
- View/download PDF