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Objectives: Identify risk factors for major perioperative complications (MPC) after anatomical lung resection for NonSmall-Cell Lung Cancer (NSCLC) and establish a scoring system. Methods: Single center retrospective study of all consecutive patients diagnosed with NSCLC submitted to anatomical lung resection from 2015 to 2019 (N=564). Exclusion criteria: previous lung surgery, concomitant non-lung cancer related procedures, urgency surgery. Study population: 520 patients. Primary end-point: MPC defined as a composite endpoint including at least one of the in-hospital complications. Univariable and Multivariable analyses were developed to identify predictors of perioperative complications and create a risk score. Discrimination was assessed using the C-statistic. Calibration was evaluated by Hosmer and Lemeshow test and internal validation was obtained by means of bootstrap replication. Results: Mean age of 65 years and 327 (62.9%) were males. Mean hospital stay of 9 days after surgery. Overall MPC rate was 23.3%. Male gender, hypertension, FEV110 points (PPV 88%). The score showed rea- sonable discrimination (C-statistic=0.70), good calibration (P=.643) and it was internally validated (C-statistic=0,70 BCa95% CI,0.65-0.79). Conclusions: This study proposes a simple and daily-life risk score system that was able to predict the incidence of perioperative complications., Portuguese Journal of Cardiac Thoracic and Vascular Surgery, Vol. 28 No. 4 (2021): October - December

Introduction: Mediastinal staging is a hot topic in thoracic oncology. According to the guidelines, and besides other criteria, in the presence of a primary lung cancer with increased mediastinal lymph node uptake on PET-CT, a negative result after lymph node sampling by Endobronchial Ultrasound (EBUS) is not enough to rule out mediastinal lymph node involve- ment, demanding a cervical mediastinoscopy to vouch for the results. Methods and Objectives: In order to study the percentage of lymph node surgical upstaging in patients with neg- ative mediastinal node staging by EBUS and evaluate the role of mediastinoscopy in these patients, we conducted a search in our department���s database using the key-word EBUS in the period concerned between January 2014 and August 2020. A total of 302 patients were found. After applying defined criteria, we obtained 42 cases. Results: Lymph node surgical upstaging occurred in 11 (26%) patients, of which 8 were upstaged to N2 and 3 to N1. Most of the cases were single station. Only in 5 (12% of the total) of the 11 patients, the upstaging was related to lymph node stations previously sampled by EBUS. Upstaging was more frequent among males and lower lobe tumours. Discussion and Conclusions: Regarding the 8 upstage cases for N2, 5 were single station. Of these 8 cases, only 5 would be approachable by cervical mediastinoscopy. Furthermore, 2 of them were single station, eligible for upfront surgery. Then, only in 3 (7%) of the 42 cases cervical mediastinoscopy would be of foremost importance., Portuguese Journal of Cardiac Thoracic and Vascular Surgery, Vol. 28 No. 4 (2021): October - December

Objectives: Compare the incidence of Postoperative atrial fibrillation (PAF) after anatomical lung resection for Non- Small-Cell Lung Cancer (NSCLC) following open surgery versus VATS. Methods: Single center retrospective study of all consecutive patients diagnosed with NSCLC submitted to anatomical lung resection from 2015 to 2019 (N=564). Exclusion criteria: prior atrial fibrillation, previous lung surgery, concomitant procedures, pneumectomy, non-pulmonary resections, urgency surgery. Study population of 439 patients. Primary end-point: incidence of PAF. Univariable analysis was used to compare the baseline characteristics of the 2 groups. Inverse probability of treatment weighting (IPTW) multivariable logistic regression was used including 23 clinical variables to analyze the effect of the approach. The balance was assessed by standardized mean differences. Results: Thoracotomy was performed in 280 patients (63.8%) and 159 (36.2%) were submitted to VATS. Patients submitted to VATS were more likely to be females, had a lower prevalence of non-adenocarcinoma cancer, stage TNM IIIIV, Diabetes Mellitus, respiratory disease, and chronic heart failure. They were submitted less often to neoadjuvant therapy, bilobectomy and they presented higher levels of diffusing capacity for carbon monoxide. After IPTW adjustment, all clinical covariates were well balanced. PAF occurred in 8.6% of the patients undergoing thoracotomy and 3,8% of the patients after VATS. After IPTW adjustment, VATS was not associated with a lower incidence of PAF (OR 0.40; CI95%:0.140-1.171; p=0.095). Conclusion: In this study, minimally invasive non���rib spreading VATS did not decrease the incidence of PAF when compared with standard thoracotomy regarding anatomical lung resection for NSCLC., Portuguese Journal of Cardiac Thoracic and Vascular Surgery, Vol. 28 No. 3 (2021): July - September

Dissertação de Mestrado em Arquitetura com a especialização em Arquitetura apresentada na Faculdade de Arquitetura da Universidade de Lisboa para obtenção do grau de Mestre. O território de Alcântara tem sido moldado ao longo dos tempos por profundas transformações. A modernização infraestrutural e os processos de desindustrialização contribuíram significativamente para uma fragmentação do tecido urbano, bem como para um conjunto vasto de terrenos vazios mantidos num estado letárgico até hoje. O presente projeto insere-se neste contexto e propõe uma reflexão sobre a regeneração dos antigos lugares industriais, segundo uma lógica de reutilização crítica e de uma intervenção baseada nos princípios de diversidade e de densidade como condição necessária para uma cidade sustentável de proximidade e que contrarie as dinâmicas de expansão para as periferias. Por conseguinte, é proposta a reabilitação da antiga Fábrica Sol e a inserção de um novo conjunto arquitetónico num programa misto que procura contribuir para o reforço de uma nova centralidade terciária neste ponto da cidade. Procura-se um desenho que estabeleça relações de continuidade e de articulação com os diversos tecidos urbanos coexistentes. Ademais, ambiciona-se a qualificação de novos espaços públicos de transição e estadia, fundamentais à vida em comunidade. Serviu, por fim, este tema, para o desenvolvimento de um processo guiado por um exercício de reformulação de hipóteses fortemente apoiado na maqueta. ABSTRACT: The territory of Alcântara has been shaped over time by profound transformations. The infrastructural modernization and the deindustrialization processes have significantly contributed to a fragmentation of the urban fabric, as well as to a vast set of vacant lands, kept in a lethargic state until today. The present project fits into this context and proposes a reflection on the regeneration of old industrial sites, according to a logic of critical reuse and an intervention based on the principles of diversity and density as a necessary condition for a sustainable city of proximity, capable of counteracting the dynamics of expansion towards the peripheries. Therefore, it is proposed the rehabilitation of the former Fábrica Sol and the insertion of a new architectural ensemble in a mixed program that seeks to contribute to the strengthening of a new tertiary centrality in this part of the city. A design that establishes a relationship of continuity and articulation with the various coexisting urban fabrics is sought. Furthermore, it aims the qualification of new public spaces of transition and stay, fundamental to community life. Finally, this theme was used to develop a process guided by an exercise of hypothesis reformulation strongly supported by the maquette. N/A

In the 1930-50s, before antimicrobial drugs, collapse therapy was the mainstream of treatment for cavitary pulmonary tuberculosis. We present an 78-year-old man with a history of pulmonary tuberculosis treated with plombage in 1962, who presented with axillary pleurocutaneous fistula (Figure 1). The patient was submitted to surgical extraction of 21 lucite balls, pleurocutaneous drainage and thoracoplasty (Figure 2)., Portuguese Journal of Cardiac Thoracic and Vascular Surgery, Vol. 26 No. 3 (2019): July - September

Pancoast tumours are defined as tumours arising from the upper lobe and invading the thoracic inlet,representing less than 5% of all lung cancers. Clinical features depend on the involved structures. For many years invasion of the spine was considered unresectable and fatal. Due to the progress in spine surgery, en bloc resection including the spine is nowadays possible. We report the first case of a successful en bloc vertebral resection of a Pancoast tumour in a 66 year-old male, with a squamous cell carcinoma, treated at our department in a multidisciplinary setting, after induction chemoradiotherapy. An en bloc resection including the left upper lobe, the first three ribs and the vertebral body of D2, was performed through a Paulson incision after posterior cervico-dorsal arthrodesis. A complete R0 resection was confirmed on the pathology specimen. Currently, one year after surgery, although no local recurrence has occurred, the patient is being treated with immunotherapy due to disease progression in the right acetabulum which was irradiated (20Gy) and then submitted to iliac resection and prothesis reconstruction., Portuguese Journal of Cardiac Thoracic and Vascular Surgery, Vol. 28 No. 1 (2021): January - March

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Additional file 1: Table S1. Forward and reverse oligonucleotide sequences of target gene primers.

Chronic obstructive pulmonary disease (COPD) is a progressive and disabling disorder marked by airflow limitation and extensive destruction of lung parenchyma. Cigarette smoke is the major risk factor for COPD development and has been associated with increased oxidant burden on multiple cell types in the lungs. Elevated levels of reactive oxygen species (ROS) may significantly affect expression of biological molecules, signaling pathways, and function of antioxidant defenses. Although inflammatory cells, such as neutrophils and macrophages, contribute to the release of large quantities of ROS, mitochondrial dysfunction plays a critical role in ROS production due to oxidative phosphorylation. Although mitochondria are dynamic organelles, excess oxidative stress is able to alter mitochondrial function, morphology, and RNA and protein content. Indeed, mitochondria may change their shape by undergoing fusion (regulated by mitofusin 1, mitofusin 2, and optic atrophy 1 proteins) and fission (regulated by dynamin-related protein 1), which are essential processes to maintain a healthy and functional mitochondrial network. Cigarette smoke can induce mitochondrial hyperfusion, thus reducing mitochondrial quality control and cellular stress resistance. Furthermore, diminished levels of enzymes involved in the mitophagy process, such as Parkin (a ubiquitin ligase E3) and the PTEN-induced putative kinase 1 (PINK1), are commonly observed in COPD and correlate directly with faulty removal of dysfunctional mitochondria and consequent cell senescence in this disorder. In this review, we highlight the main mechanisms for the regulation of mitochondrial quality and how they are affected by oxidative stress during COPD development and progression.

Additional file 2: Figure S1. Short-axis view of the left and right ventricles (upper panels) and pulmonary Doppler (lower panels).

Additional file 3: Table S2. Semiquantitative analysis of lung electron microscopy. Figure S2. Transmission electron photomicrographs of lung parenchyma.

O uso da tecnologia como ferramenta de ensino pode auxiliar no processo educacional e, por consequência, na rotina de todos os atores envolvidos nesse processo – alunos, professores e gestores. As consequências (positivas e negativas) provenientes da aplicação da tecnologia no âmbito educacional dependem do uso que fazemos dela e da sua influência nas rotinas de trabalho. Velloso (2014, p. 11) conceitua as Novas Tecnologias de Informação e Comunicação (NTICs) como os artifícios utilizados para agilizar, horizontalizar e facilitar a captação, a transmissão e a distribuição de informações em rede, surgidos no contexto da Terceira Revolução Industrial, desenvolvida gradativamente desde a metade da década de 1970, com seu auge nos anos de 1990. As mídias digitais podem ser utilizadas para apoiar as atividades do professor, do gestor e do aluno por facilitarem, sobretudo, o intercâmbio de informações, a visualização de forma mais clara dos recursos e o ensino colaborativo. Como ferramentas de ensino, o uso das mídias é favorecido por meio da utilização de recursos tecnológicos variados, tais como slides, exercícios virtuais, vídeos, plataformas de Ensino a Distância (EAD), webconferências, lousas digitais, e-mails, armazenamento em nuvens, entre outros.

Moraes, Isabela R. R., Bergamasco, Giovanna R., Santos, Rafael C., Antunes, Mariana, Soledade, Guidomar O., Costa, Rogerio C., Castilho, Antonio L. (2020): New record of the sponge-dwelling shrimp Typton distinctus Chace, 1972 (Decapoda: Caridea: Palaemonidae) in São Paulo State, Brazil. Zootaxa 4763 (3): 444-446, DOI: 10.11646/zootaxa.4763.3.10

Typton distinctus Chace, 1972 (Figure 1B, C) Typton distinctus��� Chace 1972: 49, figs. 13, 14; Abele & Kim 1986: 17, 189, figs. d���g; Camp 1998: 140; Ramos-Porto & Coelho 1998: 340; Coelho et al. 2006: 51; Duris et al. 2009: 1056; Souza et al. 2011: 45; Vieira et al. 2012: 31; Pachelle et al. 2015: 319. Typton carneus ��� Holthuis, 1951 pro parte: 162, pl. 51, figs. b���d, f���j, m���o [not T. carneus Holthuis, 1951, pl. 51, figs a, e, k, l]. Typton sp.��� Coelho & Ramos-Porto, 1972: 146. Material examined: 1 male (Carapace Length: 2.37 mm), Cais do Porto in Itagu�����Ubatuba, 23��27���05��� S 45��02���48��� W, Coll. Moraes & Santos, January/2019, MZUSP 40095; 1 female (Carapace Length: 1.53 mm), Cais do Porto���Ubatuba, 23��27���05��� S 45��02���48��� W, Coll. Moraes & Santos, March/2019, MZUSP 40096. Material not deposited into the Museum can be found in the Biological collection from S��o Paulo State University���Zoology Department, Botucatu-SP: 2 males, 1 female, 1 ovigerous female (Carapace Length Size: Size range: 1.53 ��� CL ��� 2.71 mm. Mean CL = 2.30 �� 0.47 mm), 23��27���05��� S 45��02���48��� W,, Cais do Porto���Ubatuba, 23��27���05��� S 45��02���48��� W, Coll. Moraes & Santos, January/2019. Description: For original descriptions and illustrations see Chace (1972); additional figures see Holthuis (1951) as Typton carneus pl. 51. Distribution: Western Atlantic: USA (Florida), Mexico (Bah��a de la Ascensi��n), Cuba (Los Arroyos), Brazil (Pernambuco, Rio de Janeiro, S��o Paulo) (Camp et al. 1998; Chace 1972; Coelho-Filho 2006; Pachelle et al. 2015; present study). Remarks: The second pair of pereiopods developed is a taxonomic characteristic of Palaemonidae shrimps, and was recognized as the most remarkable morphological feature of T. distinctus. The movable finger forms a pointed hook twist- ed into plane nearly perpendicular to that of palm (Chace, 1972) (Figure 2B, C). Pachelle et al. (2015) described some additional morphological features used to distinguish T. distinctus from a very similar conspecific, T. carneus: rostrum not ���deepening��� near midlength, the less produced ventral margin of the major chela carpus, and the mandible with a reduced incisor process. All characters were observed in our material and corroborate its identification as T. disctinctus. Despite being recognized as ���sponge-dwelling shrimps���, the Typton genera does not present a species-specific relationship with any demosponges and can be found in association with many species of this host. In S��o Paulo state, T. fapespae has been reported living inside Mycala angulosa (Almeida et al. 2014), and in the present study, T. distintus was found in Dragmacidon reticulatus. Typton distinctus has also been found in association with other sponges from the Tedania genus. Another important aspect of this relationship is the shrimp���s intense orange-red color that matches its sponge host, which has already been observed in other shrimp/sponge associations. Therefore, despite not being a specific relationship, the color criteria must be carefully observed when analyzing these materials. The distribution of shrimps among sponge-hosts suggests that Typton shrimps actively prevent colonization by conspecifics in their sponges, protecting their resources and reducing damage to the hosts, as they are adapted to consuming spongy tissues and sequestering their host pigments (Ďuri�� et al. 2011). This new register in S��o Paulo state and the characterization of the host and shrimp provides a new perspective for studies focused on characterizing the type of symbiosis present between pontoniinaes and demosponges., Published as part of Moraes, Isabela R. R., Bergamasco, Giovanna R., Santos, Rafael C., Antunes, Mariana, Soledade, Guidomar O., Costa, Rogerio C. & Castilho, Antonio L., 2020, New record of the sponge-dwelling shrimp Typton distinctus Chace, 1972 (Decapoda: Caridea: Palaemonidae) in S��o Paulo State, Brazil, pp. 444-446 in Zootaxa 4763 (3) on pages 444-445, DOI: 10.11646/zootaxa.4763.3.10, http://zenodo.org/record/3762002, {"references":["Chace, F. A. (1972) The shrimps of the Smithsonian-Bredin Caribbean Expeditions with a summary of the West Indian shallowwater species (Crustacea: Decapoda: Natantia). Smithsonian Contributions to Zoology, 98, 1 - 179. https: // doi. org / 10.5479 / si. 00810282.98","Camp, D. K., Lyons, W. G. & Perkins, T. H. (1998) Checklists of selected shallow-water marine invertebrates of Florida. Technical Report. Florida Marine Research Institute, St. Petersburg, Florida, 238 pp.","Coelho, P. A., De Almeida, A. O., De Souza-Filho, J. F., Bezerra, L. E. A. & Giraldes, B. W. (2006) Diversity and distribution of the marine and estuarine shrimps (Dendrobranchiata, Stenopodidea and Caridea) from North and Northeast Brazil. Zootaxa, 1221 (1), 41 - 62. https: // doi. org / 10.11646 / zootaxa. 1221.1.5","Pachelle, P. P. G., Anker, A. & Tavares, M. (2015) New and additional records of the sponge shrimp genus Typton Costa, 1844 (Decapoda: Palaemonidae) from the Brazilian coast. Papeis Avulsos de Zoologia, 55, 317 - 322. https: // doi. org / 10.1590 / 0031 - 1049.2015.55.22","Holthuis, L. B. (1951) A General Revision of the Palaemonidae (Crustacea Decapoda Natantia) of the Americas. I. the Subfamilies Euryrhynchinae and Pontoniinae. Allan Hancock Foundation Publications, 11, 1 - 332.","Coelho-Filho, P. A. (2006) Checklist of the Decapoda (Crustacea) from the outer continental shelf and seamounts from Northeast of Brazil - REVIZEE Program (NE III). Zootaxa, 1184 (1), 1 - 27. https: // doi. org / 10.11646 / zootaxa. 1184.1.1","Almeida, A. O., Anker, A. & Mantelatto, F. L. (2014) A new snapping species of the shrimp genus Typton Costa, 1844 (Decapoda: Palaemonidae) from the coast of Sao Paulo, southeastern Brazil. Zootaxa, 3835 (1), 110 - 120. https: // doi. org / 10.11646 / zootaxa. 3835.1.6","Duris, Z., Horka, I., Juracka, P. J., Petrusek, A. & Sandford, F. (2011) These squatters are not innocent: the evidence of parasitism in sponge-inhabiting shrimps. In: Zilberstein, D. (Ed.), PLoS ONE, 6, pp. e 21987. https: // doi. org / 10.1371 / journal. pone. 0021987"]}