76 results on '"Ariane J, Marelli"'
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52. Congenitally Corrected Transposition of the Great Arteries
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Ariane J. Marelli and Joseph K. Perloff
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Congenitally corrected transposition ,Great arteries ,business.industry ,Medicine ,Anatomy ,business - Published
- 2012
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53. Congenital Abnormalities of the Pericardium
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Joseph K. Perloff and Ariane J. Marelli
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medicine.anatomical_structure ,business.industry ,Medicine ,Pericardium ,Anatomy ,business - Published
- 2012
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54. Dedication
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Joseph K. Perloff and Ariane J. Marelli
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- 2012
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55. Contributors
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Charles S. Abrams, Frank J. Accurso, Nezam H. Afdhal, Cem Akin, Allen J. Aksamit, Qais Al-Awqati, Ban Mishu Allos, David Altshuler, Michael J. Aminoff, Jeffrey L. Anderson, Karl E. Anderson, Larry J. Anderson, Karen H. Antman, Aśok C. Antony, Gerald B. Appel, Frederick R. Appelbaum, William P. Arend, Paul Arguin, James O. Armitage, Cheryl A. Armstrong, M. Amin Arnaout, Robert Arnold, David Atkins, William L. Atkinson, Dennis Ausiello, Bruce R. Bacon, Grover C. Bagby, Barbara J. Bain, Dean F. Bajorin, Mark Ballow, Robert W. Baloh, Jonathan Barasch, Richard L. Barbano, Murray G. Baron, Elizabeth Barrett-Connor, Michael J. Barry, Bruce A. Barshop, John G. Bartlett, Mary Barton, Robert C. Basner, Stephen G. Baum, Daniel G. Bausch, Arnold S. Bayer, Hasan Bazari, John H. Beigel, George A. Beller, Robert M. Bennett, Joseph R. Berger, Paul Berk, Nancy Berliner, James L. Bernat, Philip J. Bierman, Bruce R. Bistrian, Joseph J. Biundo, Charles D. Blanke, Joel N. Blankson, Martin J. Blaser, William A. Blattner, Thomas P. Bleck, William E. Boden, C. Richard Boland, Jean Bolognia, Robert Bonomo, Larry Borish, Patrick J. Bosque, Randall Brand, Itzhak Brook, Enrico Brunetti, David M. Buchner, Pierre A. Buffet, H. Franklin Bunn, Peter A. Calabresi, David P. Calfee, Hugh Calkins, Douglas Cameron, Michael Camilleri, Grant W. Cannon, Maria Domenica Cappellini, Blase A. Carabello, Edgar M. Carvalho, Agustin Castellanos, Naga P. Chalasani, Henry Chambers, Mary Charlson, William P. Cheshire, Patrick F. Chinnery, David C. Christiani, David R. Clemmons, Jeffrey Cohen, Myron S. Cohen, Steven P. Cohen, Steven L. Cohn, Robert Colebunders, Joseph M. Connors, Deborah J. Cook, C. Ralph Corey, Kenneth H. Cowan, William A. Craig, Simon L. Croft, Mary K. Crow, John A. Crump, Mark R. Cullen, Gary C. Curhan, Inger K. Damon, Troy E. Daniels, Nancy Davidson, Lisa M. DeAngelis, Malcolm M. DeCamp, Carlos Del Rio, George D. Demetri, Robert H. Demling, Patricia A. Deuster, Robert B. Diasio, David J. Diemert, Kathleen B. Digre, John M. Douglas, Jeffrey M. Drazen, Stephen C. Dreskin, W. Lawrence Drew, George L. Drusano, Thomas D. DuBose, F. Daniel Duffy, Herbert L. DuPont, Madeleine Duvic, Kathryn M. Edwards, N. Lawrence Edwards, Lawrence H. Einhorn, Ronald J. Elin, George M. Eliopoulos, Perry Elliott, Jerrold J. Ellner, Louis J. Elsas, Dirk M. Elston, Ezekiel J. Emanuel, Gregory F. Erickson, Armin Ernst, Joel D. Ernst, David S. Ettinger, Amelia Evoli, Douglas O. Faigel, Gary W. Falk, Murray J. Favus, Gene Feder, Stephan D. Fihn, Gary S. Firestein, Neil Fishman, Lee A. Fleisher, Marsha D. Ford, Chris E. Forsmark, Vance G. Fowler, Jay W. Fox, Manuel A. Franco, Martyn A. French, Karen Freund, Linda P. Fried, Cem Gabay, Kenneth L. Gage, Robert F. Gagel, John N. Galgiani, Patrick G. Gallagher, Eithan Galun, Leonard Ganz, Guadalupe Garcia-Tsao, Jonathan D. Gates, William M. Geisler, Tony P. George, Dale N. Gerding, M. Eric Gershwin, Morie A. Gertz, Gordon D. Ginder, Jeffrey Ginsberg, Geoffrey S. Ginsburg, Michael Glogauer, John W. Gnann, Matthew R. Golden, Lee Goldman, Ellie J. Goldstein, Lawrence T. Goodnough, Jörg J. Goronzy, Eduardo Gotuzzo, Deborah Grady, Leslie C. Grammer, F. Anthony Greco, Harry B. Greenberg, Peter K. Gregersen, Robert C. Griggs, Lisa M. Guay-Woodford, Richard L. Guerrant, Colleen Hadigan, John D. Hainsworth, Anders Hamsten, Kenneth R. Hande, H. Hunter Handsfield, Göran K. Hansson, Rashidul Haque, Raymond C. Harris, Stephen Crane Hauser, Frederick G. Hayden, Letha Healey, Douglas C. Heimburger, Erik L. Hewlett, David R. Hill, Nicholas S. Hill, L. David Hillis, Jack Hirsh, V. Michael Holers, Steven M. Holland, Steven Hollenberg, Edward W. Hook, Laurence Huang, Leonard D. Hudson, Steven E. Hyman, Michael Iannuzzi, Robert D. Inman, Sharon K. Inouye, Karl L. Insogna, Silvio E. Inzucchi, Eric M. Isselbacher, Ahmedin Jemal, Joanna Jen, Dennis M. Jensen, Michael D. Jensen, Robert T. Jensen, Mariell Jessup, Stuart Johnson, Ralph F. Józefowicz, Stephen G. Kaler, Moses R. Kamya, Hagop Kantarjian, David R. Karp, Daniel L. Kastner, David A. Katzka, Debra K. Katzman, Carol A. Kauffman, Kenneth Kaushansky, Emmet B. Keeffe, Morton Kern, Gerald T. Keusch, David H. Kim, Matthew Kim, Louis V. Kirchhoff, Michael J. Klag, Samuel Klein, David S. Knopman, Tamsin A. Knox, Albert I. Ko, Rami S. Komrokji, Dimitrios P. Kontoyiannis, Barbara S. Koppel, Kevin Korenblat, Bruce R. Korf, Neil J. Korman, Joseph A. Kovacs, Monica Kraft, Christopher M. Kramer, Donna M. Krasnewich, Peter J. Krause, Henry M. Kronenberg, Ernst J. Kuipers, Paul Ladenson, Donald W. Landry, Nancy E. Lane, Anthony E. Lang, Richard A. Lange, George V. Lawry, Thomas H. Lee, William M. Lee, James Leggett, Adam Lerner, Stuart Levin, Stephanie M. Levine, Gary R. Lichtenstein, Henry W. Lim, Aldo A.M. Lima, Andrew H. Limper, Geoffrey S.F. Ling, Alan F. List, William C. Little, Richard F. Loeser, Bennett Lorber, Donald E. Low, Daniel R. Lucey, James R. Lupski, Henry T. Lynch, Jeffrey M. Lyness, Bruce W. Lytle, C. Ronald MacKenzie, Harriet MacMillan, Robert D. Madoff, Mark W. Mahowald, Atul Malhotra, Lionel A. Mandell, Peter Manu, Marsha D. Marcus, Ariane J. Marelli, Maurie Markman, Andrew R. Marks, Kieren A. Marr, Thomas J. Marrie, Paul Martin, Joel B. Mason, Barry M. Massie, Henry Masur, Eric L. Matteson, Toby Maurer, Emeran A. Mayer, Stephen A. McClave, F. Dennis McCool, Charles E. McCulloch, Michael A. McGuigan, John McHutchison, William McKenna, Vallerie McLaughlin, John J.V. McMurray, Mary McNaughton-Collins, Kenneth McQuaid, Frederick W. Miller, Kenneth L. Minaker, Jonathan W. Mink, Daniel R. Mishell, William E. Mitch, Mark E. Molitch, Bruce A. Molitoris, José G. Montoya, Fred Morady, Jeffrey A. Moscow, Andrew H. Murr, Robert J. Myerburg, Stanley Naguwa, Stanley J. Naides, Theodore E. Nash, Avindra Nath, Eric G. Neilson, Lawrence S. Neinstein, Thomas B. Newman, William L. Nichols, Lynnette K. Nieman, Dennis E. Niewoehner, S. Ragnar Norrby, David A. Norris, Susan O’Brien, Francis G. O’Connor, Patrick G. O’Connor, James R. O'Dell, Anne E. O'Donnell, Jae K. Oh, Jeffrey E. Olgin, Jeffrey W. Olin, Walter A. Orenstein, Douglas R. Osmon, Catherine M. Otto, Stephen A. Paget, Mark Papania, Peter G. Pappas, Pankaj Jay Pasricha, David L. Paterson, Carlo Patrono, Jean-Michel Pawlotsky, Richard D. Pearson, Eli N. Perencevich, Trish M. Perl, Michael C. Perry, William A. Petri, Marc A. Pfeffer, Perry J. Pickhardt, Gerald B. Pier, David S. Pisetsky, Marshall R. Posner, Charlene Prather, Basil A. Pruitt, Reed E. Pyeritz, Thomas C. Quinn, Jai Radhakrishnan, Ganesh Raghu, Margaret V. Ragni, Srinivasa N. Raja, S. Vincent Rajkumar, Didier Raoult, Robert W. Rebar, Annette C. Reboli, K. Rajender Reddy, Donald A. Redelmeier, Susan E. Reef, Neil M. Resnick, David B. Reuben, Herbert Y. Reynolds, Emanuel P. Rivers, Robert A. Rizza, Lewis R. Roberts, Jean-Marc Rolain, José R. Romero, G. David Roodman, Clifford Rosen, Karen Rosene-Montella, Philip J. Rosenthal, Marc E. Rothenberg, Hope S. Rugo, James A. Russell, Anil K. Rustgi, Robert A. Salata, Jane E. Salmon, Renato M. Santos, Michael N. Sawka, Andrew I. Schafer, William Schaffner, W. Michael Scheld, Eileen Schneider, Thomas J. Schnitzer, Robert T. Schooley, David L. Schriger, Steven A. Schroeder, Lynn M. Schuchter, Sam Schulman, Lawrence B. Schwartz, Robert S. Schwartz, Carlos Seas, Steven A. Seifert, Julian L. Seifter, Clay F. Semenkovich, Carol E. Semrad, F. John Service, George M. Shaw, Pamela J. Shaw, Robert S. Sherwin, Michael E. Shy, Wilmer L. Sibbitt, Ellen Sidransky, Robert F. Siliciano, Michael S. Simberkoff, David L. Simel, Karl Skorecki, Arthur S. Slutsky, Eric J. Small, Gerald W. Smetana, Frederick S. Southwick, Robert F. Spiera, Stanley M. Spinola, Pawel Stankiewicz, Paul Stark, Lynne S. Steinbach, Martin H. Steinberg, Theodore S. Steiner, David S. Stephens, David A. Stevens, William G. Stevenson, Arthur E. Stillman, James K. Stoller, John H. Stone, Edwin P. Su, Roland W. Sutter, Morton N. Swartz, Ronald S. Swerdloff, Megan Sykes, Thomas A. Tami, Susan M. Tarlo, Victoria M. Taylor, Ayalew Tefferi, Paul S. Teirstein, Sam R. Telford, Margaret Tempero, Michael J. Thun, Nina Tolkoff-Rubin, Antonella Tosti, John J. Treanor, Ronald B. Turner, Arthur C. Upton, Greet Van den Berghe, John Varga, Adrian Vella, Joseph G. Verbalis, Ronald G. Victor, Angela Vincent, Paul A. Volberding, Julie M. Vose, Robert M. Wachter, Edward H. Wagner, Edward E. Walsh, Thomas J. Walsh, Christina Wang, Christine Wanke, Stephen I. Wasserman, Heiner Wedemeyer, Geoffrey A. Weinberg, David A. Weinstein, Robert S. Weinstein, Roger D. Weiss, Martin Weisse, Jeffrey I. Weitz, Samuel A. Wells, Richard P. Wenzel, Victoria P. Werth, Sterling G. West, Cornelia M. Weyand, A. Clinton White, Christopher J. White, Perrin C. White, Richard J. Whitley, Michael P. Whyte, Samuel Wiebe, Jeanine P. Wiener-Kronish, Jennifer E. Wildes, Alexander Wilmer, William Winkenwerder, Joseph I. Wolfsdorf, Gary P. Wormser, John J. Wysolmerski, Myron Yanoff, Neal S. Young, William F. Young, Alan S.L. Yu, Mark L. Zeidel, Peter Zimetbaum, and Justin A. Zivin
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- 2012
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56. Congenital Pulmonary Valve Regurgitation
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Ariane J. Marelli and Joseph K. Perloff
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medicine.medical_specialty ,business.industry ,Internal medicine ,Cardiology ,medicine ,Congenital pulmonary valve regurgitation ,business - Published
- 2012
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57. Isolated Congenital Complete Heart Block
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Joseph K. Perloff and Ariane J. Marelli
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medicine.medical_specialty ,Congenital complete heart block ,business.industry ,Internal medicine ,medicine ,Cardiology ,business - Published
- 2012
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58. Normal or Innocent Murmurs
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Ariane J. Marelli and Joseph K. Perloff
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medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Cardiology ,Innocent murmurs ,business - Published
- 2012
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59. Congenital Obstruction to Left Atrial Flow
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Ariane J. Marelli and Joseph K. Perloff
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medicine.medical_specialty ,Flow (mathematics) ,business.industry ,Left atrial ,Internal medicine ,Cardiology ,Medicine ,business - Published
- 2012
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60. Cardiac Malpositions
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Joseph K. Perloff and Ariane J. Marelli
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- 2012
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61. Primary Pulmonary Hypertension
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Ariane J. Marelli and Joseph K. Perloff
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medicine.medical_specialty ,Primary (chemistry) ,business.industry ,Internal medicine ,Cardiology ,medicine ,business ,medicine.disease ,Pulmonary hypertension - Published
- 2012
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62. Coarctation of the Aorta and Interrupted Aortic Arch
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Joseph K. Perloff and Ariane J. Marelli
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medicine.medical_specialty ,business.industry ,Internal medicine ,Interrupted aortic arch ,medicine ,Coarctation of the aorta ,Cardiology ,medicine.disease ,business - Published
- 2012
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63. Congenital Anomalies of the Coronary Circulation
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Ariane J. Marelli and Joseph K. Perloff
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Coronary circulation ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Internal medicine ,Cardiology ,Medicine ,business - Published
- 2012
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64. Congenital Coronary Arterial Fistula
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Joseph K. Perloff and Ariane J. Marelli
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medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Cardiology ,Arterial fistula ,business - Published
- 2012
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65. Congenital Aneurysms of the Sinuses of Valsalva
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Ariane J. Marelli and Joseph K. Perloff
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business.industry ,Medicine ,business - Published
- 2012
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66. Introduction
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Joseph K. Perloff and Ariane J. Marelli
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- 2012
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67. Hypoplastic Left Heart
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Ariane J. Marelli and Joseph K. Perloff
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medicine.medical_specialty ,business.industry ,Internal medicine ,Hypoplastic left heart ,Cardiology ,Medicine ,business - Published
- 2012
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68. Acknowledgments
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Joseph K. Perloff and Ariane J. Marelli
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- 2012
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69. Double Outlet Ventricle
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Joseph K. Perloff and Ariane J. Marelli
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medicine.anatomical_structure ,Ventricle ,business.industry ,medicine ,Anatomy ,business - Published
- 2012
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70. Endocardial Fibroelastosis
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Joseph K. Perloff and Ariane J. Marelli
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- 2012
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71. Geriatric congenital heart disease: burden of disease and predictors of mortality
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Jonathan, Afilalo, Judith, Therrien, Louise, Pilote, Raluca, Ionescu-Ittu, Giuseppe, Martucci, and Ariane J, Marelli
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Adult ,Heart Defects, Congenital ,Male ,Adolescent ,Databases, Factual ,Age Factors ,Middle Aged ,Cohort Studies ,Survival Rate ,Young Adult ,Cost of Illness ,Predictive Value of Tests ,Population Surveillance ,Humans ,Female ,Aged - Abstract
The study sought to measure the prevalence, disease burden, and determinants of mortality in geriatric adults with congenital heart disease (ACHD).The population of ACHD is increasing and aging. The geriatric ACHD population has yet to be characterized.Population-based cohort study using the Quebec Congenital Heart Disease Database of all patients with congenital heart disease coming into contact with the Quebec healthcare system between 1983 and 2005. Subjects with specific diagnoses of congenital heart disease and age 65 years at time of entry into the cohort were followed for up to 15 years. The primary outcome was all-cause mortality.The geriatric ACHD cohort consisted of 3,239 patients. From 1990 to 2005, the prevalence of ACHD in older adults remained constant from 3.8 to 3.7 per 1,000 indexed to the general population (prevalence odds ratio: 0.98; 95% confidence interval [CI]: 0.93 to 1.03). The age-stratified population prevalence of ACHD was similar in older and younger adults. The most common types of congenital heart disease lesions in older adults were shunt lesions (60%), followed by valvular lesions (37%) and severe congenital heart lesions (3%). Type of ACHD and ACHD-related complications had a minor impact on mortality, which was predominantly driven by acquired comorbid conditions. The most powerful predictors of mortality in the Cox proportional hazards model were: dementia (hazard ratio [HR]: 3.24; 95% CI: 1.53 to 6.85), gastrointestinal bleed (HR: 2.79; 95% CI: 1.66 to 4.69), and chronic kidney disease (HR: 2.50; 95% CI: 1.72 to 3.65).The prevalence of geriatric ACHD is substantial, although severe lesions remain uncommon. ACHD patients that live long enough acquire general medical comorbidities, which are the pre-eminent determinants of their mortality.
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- 2011
72. Risk of stroke in adults with cyanotic congenital heart disease
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Pamela D. Miner, Joseph K. Perloff, and Ariane J. Marelli
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Adult ,Heart Defects, Congenital ,Male ,medicine.medical_specialty ,Heart disease ,medicine.medical_treatment ,Hyperviscosity ,Polycythemia ,Hematocrit ,Risk Factors ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,Bloodletting ,Stroke ,medicine.diagnostic_test ,Vascular disease ,business.industry ,Iron deficiency ,Intracranial Embolism and Thrombosis ,medicine.disease ,Surgery ,Cerebrovascular Disorders ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Complication - Abstract
BACKGROUND Adults with cyanotic congenital heart disease and elevated hematocrit levels are often phlebotomized because of an assumed risk of cerebral arterial thrombotic stroke. Whether a relation exists between hematocrit level, symptomatic erythrocytosis (hyperviscosity), and stroke remains to be established in this patient population. METHODS AND RESULTS Accordingly, 112 cyanotic patients 19-74 years old (mean, 36 +/- 11.7 years) in the UCLA Adult Congenital Heart Disease Center Registry were selected for study by virtue of continuous observation for 1-12 years (total, 748 patient-years). Patients with independent risk factors for embolic or vasospastic stroke were excluded. The study patients were then divided into two groups: 1) compensated erythrocytosis (stable hematocrit levels of 46.0-72.7% [mean, 57.5 +/- 7.2%], iron replete, absent or mild hyperviscosity symptoms), and 2) decompensated erythrocytosis (unstable rising hematocrit levels of 61.5-75.0% [mean, 69.5 +/- 10.6%], iron deficiency, marked-to-severe hyperviscosity symptoms). No patient with either compensated or decompensated erythrocytosis, irrespective of hematocrit level, iron stores, or the presence, degree, or recurrence of cerebral hyperviscosity symptoms, progressed to clinical evidence of a complete stroke (cerebral arterial thrombosis with brain infarction). CONCLUSIONS Because a risk of stroke caused by cerebral arterial thrombosis was not demonstrated, because the circulatory effects of phlebotomy are transient, and because of the untoward sequelae of phlebotomy-induced iron deficiency, we recommend phlebotomy for the temporary relief of significant, intrusive hyperviscosity symptoms but not for the hematocrit level per se. According to our data, phlebotomy is not warranted to reduce an assumed risk of stroke because that risk did not materialize.
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- 1993
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73. Diagnosis of pulmonary hypertension in the congenital heart disease adult population impact on outcomes
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Boris S, Lowe, Judith, Therrien, Raluca, Ionescu-Ittu, Louise, Pilote, Giuseppe, Martucci, and Ariane J, Marelli
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Adult ,Heart Defects, Congenital ,Heart Failure ,Male ,Risk ,Cardiac Catheterization ,Hypertension, Pulmonary ,Arrhythmias, Cardiac ,Middle Aged ,United States ,Hospitalization ,Intensive Care Units ,Echocardiography ,Multivariate Analysis ,Ambulatory Care ,Prevalence ,Humans ,Female ,Longitudinal Studies ,Emergency Service, Hospital ,Aged ,Retrospective Studies - Abstract
The aim of this study was to assess the impact of the diagnosis of pulmonary hypertension (PH) on mortality, morbidity, and health services utilization (HSU) in an adult congenital heart disease (CHD) population.Although PH is a well-recognized complication of CHD, population-based studies of its significance on the survival and functional capacity of patients are uncommon.A retrospective longitudinal cohort study was conducted in an adult CHD population with 23 years of follow-up, from 1983 to 2005. The prevalence of PH was measured in 2005. Mortality, morbidity, and HSU outcomes were compared between patients with and without diagnoses of PH using multivariate Cox (mortality and morbidity) and Poisson (HSU) regression models within a subcohort matched for age and CHD lesion type.Of 38,430 adults alive with CHD in 2005, 2,212 (5.8%) had diagnoses of PH (median age 67 years, 59% women). The diagnosis of PH increased the all-cause mortality rate of adults with CHD more than 2-fold compared with patients without PH (hazard ratio [HR]: 2.69; 95% confidence interval [CI]: 2.41 to 2.99). Morbid complications including heart failure and arrhythmia occurred with a 3-fold higher risk compared with patients without PH (HR: 3.01; 95% CI: 2.80 to 3.22). The utilization of inpatient and outpatient services was increased, especially cardiac catheterization, excluding the index diagnostic study (rate ratio: 5.04; 95% CI: 4.27 to 5.93) and coronary and intensive care hospitalizations (rate ratio: 5.03; 95% CI: 4.86 to 5.20).A diagnosis of PH in adults with CHD is associated with a more than 2-fold higher risk for all-cause mortality and 3-fold higher rates of HSU, reflecting high morbidity.
- Published
- 2010
74. Electrocardiography in Adult Congenital Heart Disease
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Paul Khairy and Ariane J. Marelli
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- 2010
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75. Clinical use of electrocardiography in adults with congenital heart disease
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Paul Khairy and Ariane J. Marelli
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Adult ,Heart Defects, Congenital ,Male ,medicine.medical_specialty ,Heart disease ,Atrial Appendage ,Purkinje Fibers ,Electrocardiography ,Physiology (medical) ,Internal medicine ,Medicine ,Humans ,cardiovascular diseases ,Tricuspid atresia ,Atrium (heart) ,Sinus (anatomy) ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Cavoatrial junction ,medicine.anatomical_structure ,Cardiology ,Atrioventricular Node ,Female ,Electrical conduction system of the heart ,Cardiology and Cardiovascular Medicine ,business - Abstract
The prevalence of adult congenital heart disease (ACHD) has risen markedly over the past 2 decades, with the number of adults now rivaling the number of children with severe defects.1 This is, perhaps, not surprising given that current care allows nearly 90% of infants born with heart defects to thrive into their adult years.1,2 This remarkable triumph is tempered, however, by the realization that early interventions were reparative and not curative. Numerous complications may surface years after uneventful childhood courses, justifying vigilant clinical follow-up throughout adulthood. The 12-lead ECG remains an invaluable cornerstone in the clinical appraisal of adults with congenital heart disease that, in certain circumstances, provides diagnostic and/or prognostic information. The present review imparts a clinical perspective to ECG interpretation in ACHD, emphasizing practical and pathogenomonic findings in the more frequently encountered congenital defects in adults. Anatomic features of the conduction system relevant to ECG findings in ACHD are summarized, including variations in the location of the sinus node, atrioventricular (AV) node, and His-Purkinje system. Thereafter, pertinent ECG features are highlighted for common subtypes of ACHD (Table). Examples are provided throughout for illustration. View this table: Table. Typical ECG Features in Common Forms of ACHD ### Sinus Node In the morphologically normal heart, a crescent-shaped sinus node is characteristically located epicardially along the lateral aspect of the superior cavoatrial junction. It generates a P-wave axis typically between 15° and 75°. Most patients with ACHD have normally positioned atrial chambers, called atrial situs solitus, with normal sinus node location. The position of the sinus node may, however, vary with the atrial chambers and their appendages. #### Juxtaposition of the Atrial Appendages In juxtaposition of the atrial appendages, both appendages are on the same side of the arterial pedicle rather than each being ipsilateral to its respective atrium. Left juxtaposition, with left-sided atrial appendages, frequently accompanies tricuspid atresia and has …
- Published
- 2007
76. 735-3 A Study of 1044 Consecutive Patients with Patent Foramen Ovale: Association with Cryptogenic Cerebrovascular Events in Adults
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Richard R. Liberthson, Stella Brili, Ariane J. Marelli, Michael H. Picard, Mary Etta King, Sumita D. Paul, John B. Newell, and Peter Lang
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medicine.medical_specialty ,Pediatrics ,business.industry ,Medical record ,medicine.disease ,law.invention ,Aneurysm ,Hematoma ,Randomized controlled trial ,law ,Internal medicine ,Cardiology ,medicine ,Patent foramen ovale ,Arteritis ,Cardiology and Cardiovascular Medicine ,Prospective cohort study ,business ,Stroke - Abstract
The natural history of patent foramen ovale (PFO) in association with cerebrovascular (CV) events has not been described. With the development of devices for non-surgical closure of atrial septal defect, it is possible that the risk of PFO closure may be minimal. However, the potential benefit of PFO closure remains unknown and difficult to assess due lack of adequate data. To determine the prevalence of PFO and its association with cryptogenic (CRYP) and non-cryptogenic (NON) stroke, we examined the database of 37,940 consecutive pts who underwent echocardiography between 1984 to 1994, to identify pts diagnosed with PFO (n = 1044) and designed an age-matched nested case-control study with 2088 pts to determine the association of CV events to PFO. All CV events were confirmed by review of medical records. NON stroke was defined: cardiogenic, atherosclerotic, lacunar, arteritis, aneurysm, hematoma. CRYP stroke was diagnosed by exclusion when the event could not be ascribed to causes in the NON group. Results The age distribution is given below: Age PFO Stroke (PFO group) Stroke (Control group) (yrs) NON CRYP NON CRYP 0-1 520(26%) 1 0 0 0 1-18 88(2%) 0 0 1 0 18-50 127(1%) 9 13 1 0 g 50 309(1%) 23 5 28 5 A greater number of adults with CV events were identified in the PFO group (50) vs control group (34). p l 0.07. The proportion of adults with cryptogenic stroke was significantly higher in the PFO group (18/50,36%) vs control group (5/34, 15%), p l 0.04. Conclusions 1. The prevalence of PFO decreases from the neonate to the adult. 2. There is a high prevalence of cryptogenic stroke among adults with PFO who have suffered a cerebrovascular event. 3. These results provide a baseline for designing future prospective studies of PFO and CV events, and randomized trials to determine the impact of PFO closure.
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- 1995
- Full Text
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