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61. ZC3H7B-BCORhigh-grade endometrial stromal sarcomas: a report of 17 cases of a newly defined entity

Author

Lewis, Natasha, Soslow, Robert A, Delair, Deborah F, Park, Kay J, Murali, Rajmohan, Hollmann, Travis J, Davidson, Ben, Micci, Francesca, Panagopoulos, Ioannis, Hoang, Lien N, Arias-Stella, Javier A, Oliva, Esther, Young, Robert H, Hensley, Martee L, Leitao, Mario M, Hameed, Meera, Benayed, Ryma, Ladanyi, Marc, Frosina, Denise, Jungbluth, Achim A, Antonescu, Cristina R, and Chiang, Sarah

Abstract

High-grade endometrial stromal sarcoma likely encompasses underrecognized tumors harboring genetic abnormalities besides YWHAE–NUTM2fusion. Triggered by three initial endometrial stromal sarcomas with ZC3H7B–BCORfusion characterized by high-grade morphology and aggressive clinical behavior, we herein investigate the clinicopathologic features of this genetic subset by expanding the analysis to 17 such tumors. All of them occurred in adult women with a median age of 54 (range, 28–71) years. They were predominantly based in the endomyometrium and demonstrated tongue-like and/or pushing myometrial invasion. Most were uniformly cellular and displayed haphazard fascicles of spindle cells with mild to moderate nuclear atypia. Myxoid matrix was seen in 14 of 17 (82%) tumors, and collagen plaques were seen in 8 (47%). The mitotic index was ≥10 mitotic figures/10 high-power fields (HPFs) in 14 of 17 (82%) tumors with a median of 14.5 mitotic figures/10 HPFs. No foci of conventional or variant low-grade endometrial stromal sarcoma were seen. All tumors expressed CD10 with only limited or absent desmin, SMA and/or h-caldesmon staining. ER and PR expression in >5% of cells was seen in 4 of 12 (33%) tumors. Diffuse cyclin D1 and BCOR immunoreactivity was present in 7 of 8 (88%) and 7 of 14 (50%) tumors, respectively. Fluorescence in situhybridization or targeted RNA sequencing confirmed ZC3H7B–BCORfusion in all tumors, including four and two previously diagnosed as myxoid leiomyosarcoma and undifferentiated uterine sarcoma, respectively. Limited clinical data suggest that patients present at higher stage and have worse prognosis compared with published outcomes in low-grade endometrial stromal sarcoma. Tumors with ZC3H7B–BCORfusion constitute a distinct group of endometrial stromal sarcomas with high-grade morphology that should be distinguished from other uterine mesenchymal neoplasms that may demonstrate myxoid morphology.

Published
2018
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62. Obama y la investigación en células madre embrionarias humanas

Author

Arias-Stella, Javier and Arias-Stella, Javier

Abstract

The most recent and astonishing scientific advances have allowed the development of fertilization techniques based on the somatic cell nuclear transfer method. Thanks to this, it has been possible to widen knowledge about embryo cells, maintaining their pluripotentiality and now there are some cell banks available for therapeutic purposes. However, embryo cell manipulation has been the subject of many discussion from the scientific, ethics, and politics point of view, because of many fears generated by the likelihood of manipulating the genetic machinery of a non-differentiated totipotent stem cell. In the last Presidential Elections in the USA, Mr. Barack Obama proimised to strengthen research in this promising field. This promise opens the way for many patients that are awaiing for therapy options that nowadays still are not possible., El increíble avance científico ha permitido el desarrollo de tecnologías de fertilización por transferencia nuclear de células somáticas. Gracias ha estos adelantos ha sido posible desarrollar el conocimiento sobre las células embrionarias, el mantenimiento de su pluripotencialidad y la existencia de bancos de células con fines terapéuticos. Sin embargo la manipulación de células embrionarias no ha estado exenta de una ardua discusión científica, ética y política en base a los temores que genera el poder manejar a voluntad la maquinaria genética totipotente de una célula madre indiferenciada. En las últimas elecciones presidenciales de los Estados Unidos de Norteamérica, el entonces candidato Obama y ahora presidente prometió impulsar nuevamente la investigación en este campo. Esta promesa abre la esperanza para muchos que esperan opciones terapéuticas hoy imposibles.

Published
2009

72. Decrease in prevalence of peptic ulcer and gastric adenocarcinoma at the Policlínico Peruano Japones, Lima, Peru, between the years 1985 and 2002. Analysis of 31,446 patients.

Author

Universidad Peruana Cayetano Heredia, Lima, Perú, Ramírez-Ramos, Alberto, Watanabe-Yamamoto, José, Takano-Morón, Juan, Gilman, Robert H, Recavarren Arce, Sixto, Arias-Stella, Javier, Yoshiwara-Wakabayashi, Elena, Rodríguez-Ulloa, Carlos, Miyagui-Maeda, Juan, Chinga-Alayo, Erick, Mendoza-Requena, Daniel, Leey-Casella, Julio, Rosas Aguirre, Angel, Velapatiño-Cochachi, Billie, Guerra Valencia, Daniel, Universidad Peruana Cayetano Heredia, Lima, Perú, Ramírez-Ramos, Alberto, Watanabe-Yamamoto, José, Takano-Morón, Juan, Gilman, Robert H, Recavarren Arce, Sixto, Arias-Stella, Javier, Yoshiwara-Wakabayashi, Elena, Rodríguez-Ulloa, Carlos, Miyagui-Maeda, Juan, Chinga-Alayo, Erick, Mendoza-Requena, Daniel, Leey-Casella, Julio, Rosas Aguirre, Angel, Velapatiño-Cochachi, Billie, and Guerra Valencia, Daniel

Abstract

AIM: To determine the prevalence of peptic ulcer and gastric adenocarcinoma in a population of middle and high socio-economic status in Lima, Peru, between 1985 and 2002. MATERIAL AND METHODS: The prevalence of gastroduodenal ulcer and gastric adenocarcinoma was determined after studying by esophagogastroduodenoscopy 31,446 patients at the Policlínico Peruano Japonds (PPJ) between 1985 and 2002. All patients had chronic upper gastrointestinal symptoms and had endoscopically proven diagnosis of active peptic ulcer or histological diagnosis of gastric adenocarcinoma. RESULTS: Analysis of PPJ population identified a decrease in the prevalence of gastric ulcer and duodenal ulcer from 3.15% and 5.05% respectively in 1985, to 1.62% and 2.00% respectively in 2002. Gastric adenocarcinoma prevalence also decreased from 3.19% in 1988 to 0.92% in 2002. The prevalences of gastric ulcer (OR = 1.49, 95% IC 1.26-1.77, p < 0.001), duodenal ulcer (OR = 1.32, 95% IC 1.15-1.51, p < 0.001) and gastric adenocarcinoma (OR = 1.53, 95% IC 1.25-1.86, p < 0.001), decreased in the last eight years. CONCLUSIONS: Over the study period, there was a significant decrease in the prevalence of peptic ulcer and gastric adenocarcinoma at the Policlinico Peruano Japonés, where patients from middle and high socio economic status are attended.

Published
2006

74. Incontinentia pigmenti: A propósito de un caso

Author

Tori Tori, Carlos, Villar De Cipriani, Enriqueta, Arias Stella, Javier, and Avalos, Carmen

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, Bloch Sulzberger, children, neuroectodermic, sense organs, Incontinentia Pigmenti, skin and connective tissue diseases, melanin
Abstract

Incontinentia Pigmenti is a rare X-linked multisystem neuroectodermic disorder with signs and symptoms related mainly to the dermatologic, dental, ocular and central nervous systems, and characterized by death in the majority of male embryos. Affected children do not appear sick, in spite of the skin eruption, the peripheral leucocytosis and marked eosinophilia. Most of the cases are reported in caucasians, although there are description in black children, orientals, north central and south american Indians, and in our mestizos. The name of Incontinentia Pigmenti describes the incontinence of the melanin pigment from the basal layer of the epidemermis into the superficial dermis.

Published
1995

76. Comparación citológica entre las técnicas de espátula de ayre y citoescobilla (cytobrush) en la toma de muestras cervicovaginales

Author

Arias Stella, Javier, Arias, Abelardo, González del Riego, Manuel, SAONA, Pedro, Arias Stella, Javier, Arias, Abelardo, González del Riego, Manuel, and SAONA, Pedro

Abstract

Objective: To compare Ayre spatula and cytobrush methods in uterine cervix premalignant and malignant lesions detection. Material and Methods: Endocervical smears taken from 140 patients with the Ayre spatula and cytobrush methods were extended on separate codified slides and examined by two different pathologists unaware of the smear collection method. Bethesda system was used for diagnosis. Results: Sixty-five versus thirty-five per cent of the samples had endocervical cells respectively obtained with the cytobrush and the Ayre spatula method. When analyzing the quantity of endocervical cells, the samples obtained with the cytobrush method had more than five clusters of endocervical cells (71,4%) than with the Ayre spatula method (36,4%). Conclusion: Cytobrush method seems to be more efficient than Ayre spatula method for obtaining endocervical cells., Objetivo: Comparar la eficacia de los métodos de espátula de Ayre y la citoescobilla ("cytobrush") en la detección de lesiones premalignas y malignas del cérvix uterino. Material y Métodos: Las muestras de raspado de cérvix uterino de 140 pacientes, usando las técnicas de la espátula de Ayre y citoescobilla, fueron extendidas sobre láminas separadas y codificadas, siendo examinadas por dos diferentes patólogos que desconocían el método de recolección de la muestra. Se usó el sistema de Bethesda para el diagnóstico. Resultados: De las muestras obtenidas, 65% vs. 35% tuvieron células endocervicales con el método de la citoescobilla y la espátula de Ayre, respectivamente. Al analizar la cantidad de células endocervicales, las muestras obtenidas por el método de citoescobilla tuvieron más de cinco grupos de células endocervicales, 71,4% vs. 36,4% con la espátula de Ayre. Conclusión: A pesar que el método de la espátula de Ayre es eficiente para la obtención de células endocervicales, el método de la citoescobilla dio mejores resultados en nuestro estudio.

Published
2001

78. Progression of a hepatosplenic gamma delta T-cell leukemia/lymphoma on hyper CVAD/ MTX and ara-C: literature review and our institutional treatment approach.

Author

Saste, Abhijit, Arias‐Stella, Javier, and Kuriakose, Philip

Subjects
*ADULT T-cell leukemia, *HTLV diseases, *LEUKEMIA, *LYMPHOMAS, *HEMATOLOGIC malignancies
Abstract

Key Clinical Message A 24-year-old male presented with abdominal pain, fever, and palpable splenomegaly. His differential count revealed myelocytes, metamyelocytes, and nucleated red cells. A bone marrow biopsy confirmed a diagnosis of hepatosplenic gamma delta T-cell leukemia/lymphoma. We describe here our center's diagnostic and treatment approach for this rare leukemia. [ABSTRACT FROM AUTHOR]

Published
2016
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81. Primera experiencia de telepatología robótica en Perú.

Author

Castillo, Javier Arias-Stella, Valdés-Gómez, Jorge, Yance-Chávez, Tula, and Arias-Stella, Javier

Subjects
MEDICAL robotics, UNIVERSITIES & colleges, PILOT projects
Abstract

Copyright of Patologia Revista Latinoamericana is the property of Asociacion Latinoamericana de Patologia/Asociacion Mexicana de Patologia/Consejo Mexicano de Medicos and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2009

88. Pathology of chronic mountain sickness.

Author

Arias-Stella, Javier, Krüger, Hever, Recavarren, Sixto, Arias-Stella, J, Krüger, H, and Recavarren, S

Subjects
ALTITUDES, AUTOPSY, CHRONIC diseases, CYANOSIS, HEART ventricles, HYPERTROPHY, LUNGS, POLYCYTHEMIA, PULMONARY artery
Abstract

, , 701-708. Pathological data on chronic mountain sickness are scarce due to the fact that the disease is ameliorated or cured by descent to a low altitude. In this report we describe a case of chronic mountain sickness occurring in a woman of 48 years at Cerro de Pasco (4,300 m above sea level). The necropsy findings are compared with the limited pathological observations reported by others. It is apparent from our findings that in fatal cases the main changes are located within the pulmonary circulation. So far histological studies have been reported only in cases of the secondary form of chronic mountain sickness. The basic pathology of the primary form (Monge's disease) remains to be defined. [ABSTRACT FROM PUBLISHER]

Published
1973

91. The placenta and the newborn infant at high altitudes

Author

Krüger, Hever and Arias-Stella, Javier

Abstract

A comparative study of the placenta and the newborn infant at Rio Pallanga (altitude 15,100 feet) and Lima (500 feet) is presented. Three parameters were analyzed, the weight of the newborn infant, the weight of the placenta, and the ratio of the weight of the placenta to the weight of the newborn infant (placental coefficient). The mean values of these parameters were analyzed according to Fisher's t test. The results showed that: (1) at high altitudes, the newborn infants weighed significantly less than those born at sea level; (2) the placentas at high altitude weighed more than the placentas at sea level; (3) the value for the placental coefficient at high altitudes was significantly higher than at sea level; (4) the number of cotyledons in high-altitude placentas was half that of sea level placentas, indicating a lesser degree of septation and probably a greater proportion of functioning parenchyma; and (5) no differences were found in the volumes of the placentas. The physiologic role of the placenta at high altitudes is discussed.

Published
1970
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94. Cambios Epiteliales Atípicos en las Vesículas Seminales

Author

Arias Stella, Javier and Takano Morón, Juan

Abstract

The morphological characteristics of atypical epithelial disruption occurs in the seminal vesicle are described. The lesion is mainly characterized by focal areas in which there is marked nuclear hypertrophy and some degree of epithelial hyperplasia. The exioliadas hypertrophic cells can be confused with neoplastic cells. The alteration occurs mostly after the fourth decade. Inflammation and vascular sclerosis in the seminal vesicle, prostate gland hyperplasia, abnormality or atrophy of the testes, or pathological processes in each case apparently unrelated to the presence of the disturbance. Se describen las características morfológicas de una alteración epitelial atípica que ocurre en la vesícula seminal. La lesión se caracteriza fundamentalmente por áreas focales en las que hay marcada hipertrofia nuclear y algún grado de hiperplasia epitelial. Las células hipertróficas exioliadas pueden ser confundidas con células neoplásicas. La alteración ocurre mayormente después de la cuarta década. La inflamación y la esclerosis vascular en la vesícula seminal, la hiperplasia de la glándula prostática, la anormalidad o atrofia de los testículos, o los procesos patológicos en cada caso aparentemente no guardan relación con la presencia de la alteración.

Published
1959

95. Estudio topográfico de la alteración endometrial atípica asociada a la presencia de tejido coriónico. Demostración de la alteración en el endocervix

Author

Arias Stella, Javier

Abstract

In 1954 we made the description and characterization of endometrial epithelial one alteration that occurs in some cases of chorionic, mola hidcrtidiforme, destruens chorioadenoma, cervical ectopic pregnancy and abortion. The alteration is characterized mainly by a nuclear hypertrophy with enlargement to a lesser degree in the cytoplasm and loss trend cell polarization. The affected glands may be secretory or proliferative, or show a pathological secretory and proliferative activity simultaneously. The cover may show epithelial injury. The alteration occurs focally compromising all or part of a gland or glands groups. Rarely is more or less diffuse. It may or not be decidual reaction., En el año 1954 hicimos la descripción y caracterización de uno alteración del epitelio endometrial que ocurre en algunos casos de corioepitelioma, mola hidcrtidiforme, corioadenoma destruens, embarazo ectópico y aborto uterino. La alteración se caracteriza fundamentalmente, por una hipertrofía nuclear con agrandamiento en menor grado del citoplasma y tendencia a la pérdida de la polarización celular. Las glándulas afectadas pueden ser de tipo secretorio o proliferativo, o mostrar una patológica actividad secretoria y proliferativa simultáneamente. El epitelio de cubierta puede mostrar la lesión. La alteración ocurre de manera focal comprometiendo toda o parte de una glándula o grupos de glándulas. Rara vez es más o menos difusa. Puede o nó haber reacción decidual.

Published
1956

96. Contribución al estudio de la Hepatitis Viral Endemo-Epidémica en Abancay

Author

Gastelumendi V., René, Burstein P., Meilach, León Barúa, Raúl, and Arias Stella, Javier

Abstract

There Abancay in certain condition that causes jaundice region and has attracted interest from Pimero days of the Republic., Existe en la región Abancay cierta afección que cursa con ictericia y que ha suscitado interés desde los pimeros tiempos de la República.

Published
1960

99. Cambios endometriales anormales producidos en la rata por estrógenos y hormona criónica

Author

Arias Stella, Javier

Abstract

The administration of human chorionic hormone and estrogen to normal rats, produces an atypical endometrial characterized histological simultaneous presence of proliferative and secretory changes. The core of epithelial cells shows that overall a more normal appearance and occasionally reaching vesicular large. Abnormal box can not be induced by treating rats with normal or chorionic estróqenos administered alone or both hormones to castrated animals. A similar alteration is, however; when ovariectomized rats are treated with large doses of estrogen and progesterone. Pathogenesis and the possible relationship of this alteration certain endometrial changes seen in humans is briefly discussed., La administración de hormona coríónica humana y estrógeno a ratas normales, produce un cuadro histológico endometrial atípico caracterizado por presencia simultánea de cambios proliferativos y secretorios. El núcleo de las células epiteliales muestra en general un aspecto más vesicular que lo normal y ocasionalmente alcanza gran tamaño. El cuadro anormal no puede ser inducido tratando a las ratas normales con estróqenos u hormones coriónicos aisladamente o administrando ambas a animales castrados. Una alteración similar se ve, sin embargo; cuando ratas ooforectomizadas son tratadas con grandes dosis de estrógenos y progesterona. Se discute brevemente la patogenia y la posible relacíón de esta alteración con ciertos cambios endometriales observados en seres humanos.

Published
1957

100. Concepto de enfermedad neoplásica cervical

Author

Arias Stella, Javier, Castillo Jessen, María, Arias Stella, Javier, and Castillo Jessen, María

Abstract

Histological epidemiological experience, clinical, colposcopic, cytologic and has a solid foundation to the concept of cervical intraepithelial neoplastic disease. The various forms of dysplasia, carcinoma in situ and microinvasive carcinoma are thus initial understood as invasive evolving forms of the same biological process whose ultimate expression is the invasive carcinoma. With the appointment today of dysplasia qualify all atypical proliferations epidermoideas prior to cervical carcinoma in-situ. Cervical intraepithelial neoplastic disease is characterized by periods evolve regression and reoccurrence. The mild and moderate forms of dysplasia regressed more frequently than in-situ forms of severe dysplasia and carcinoma, rarely do. The origin of cervical neoplastic disease can be level or endocervix ectocervix. Most often it starts in the vicinity of the squamocolumnar area. A minority of epidermoideos infiltrating carcinomas are not part of the cervical neoplasm discussed here and have a different histogenesis., La experiencia epidemiológica, clínica, colposcópica, citológica e histológica ha dado una sólida base al concepto de enfermedad neoplásica cervical intraepitelial. Las distintas formas de displasia, el carcinoma in-situ y el carcinoma microinvasivo inicial quedan así comprendidas como formas evolutivas no invasoras de un mismo proceso biológico cuya expresión final es el carcinoma infiltrante. Con la designación de displasia se califican hoy todas las proliferaciones atípicas epidermoideas cervicales anteriores al carcinoma in-situ. La enfermedad neoplásica cervical intraepitelial se caracteriza por evolucionar con períodos de regresión y recurrencia. Las modalidades leve y moderada de displasia regresionan más frecuentemente que las formas de displasia severa y carcinoma in-situ que, rara vez lo hacen. El origen de la enfermedad neoplásica cervical puede ser a nivel del endocérvix o del exocérvix. Lo más frecuente es que se inicie en la cercanía de la zona escamocolumnar. Una minoría de carcinomas epidermoideos infiltrantes no son parte de la enfermedad neoplásica cervical aquí discutida y tienen una histogénesis diferente.

Published
1971

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