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52. A NEGATIVE VIEW OF THE NEGATIVE MONEY MULTIPLIER: COMMENT.

Author

AUERBACH, ROBERT D. and RUTNER, JACK L.

Subjects
BUDGET process, MONETARY policy, OPEN market operations, MONETARY theory, PUBLIC spending, ACCOUNTS receivable, ACADEMIC debating, ECONOMIC models, ECONOMIC equilibrium, INTEREST rates
Abstract

In a recent issue of this Journal, Frank Steindl (1974), drawing on his previous article in the Journal of Political Economy (Steindl, 1971) which contained a reduced form of Carl Christ's "A Simple Macroeconomic Model with a Government Budget Restraint" (Christ, 1968), purported to show that the money multiplier is negative. The purpose of this paper is to show that Steindl's definition of equilibrium might be theoretically as well as empirically uninteresting, both because his model is largely vacuous and because it depends on a reaction between the economy and the government which may make his solution unachievable. [ABSTRACT FROM AUTHOR]

Published
1977
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59. LIST OF CONFEREES

Author

Argyris, Bertie F., primary, Auerbach, Robert, additional, Benacerraf, Baruj, additional, Braun, Werner, additional, Britton, Sven, additional, Bussard, Alain E., additional, Ceppellini, Ruggero, additional, Cinader, B., additional, Cohn, Melvin, additional, Davies, D.A.L., additional, Edelman, Gerald M., additional, Friedman, Herman, additional, Gell, P.G.H., additional, Golub, Edward, additional, Good, Robert A., additional, Gottlieb, A. Arthur, additional, Gowans, J.L., additional, Hasek, Milan, additional, Howard, James, additional, Humphrey, J.H., additional, Landy, Maurice, additional, Leskowitz, Sidney, additional, Miller, J.F.A.P., additional, Mitchison, N.A., additional, Möller, Erna, additional, Möller, Goran, additional, Munro, Alan, additional, Nossal, G.J.V., additional, Plescia, Otto J., additional, Rajewsky, K., additional, Schwartz, Robert S., additional, Sela, Michael, additional, Sercarz, Eli, additional, Silverstein, Arthur M., additional, Simonsen, Morten, additional, Siskind, Gregory W., additional, Smith, Richard T., additional, Sterzl, J., additional, Jeanette Thorbecke, G., additional, Uhr, Jonathan W., additional, Waksman, Byron H., additional, and Weigle, William O., additional

Published
1969
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60. Interleukin-12 Inhibits Tumor Growth in a Novel Angiogenesis Canine Hemangiosarcoma Xenograft Model1

Author

Akhtar, Nasim, Padilla, Marcia L, Dickerson, Erin B, Steinberg, Howard, Breen, Matthew, Auerbach, Robert, and Helfand, Stuart C

Subjects
Mice, Inbred BALB C, Neovascularization, Pathologic, Reverse Transcriptase Polymerase Chain Reaction, Hemangiosarcoma, Transplantation, Heterologous, Soft Tissue Neoplasms, Mice, SCID, Flow Cytometry, Interleukin-12, Mice, Dogs, Mice, Inbred NOD, Biomarkers, Tumor, Cell Adhesion, Tumor Cells, Cultured, Animals, Cytokines, Corneal Neovascularization, Endothelium, Vascular, Growth Substances, Cell Division, Neoplasm Transplantation, Research Article
Abstract

We established a canine hemangiosarcoma cell line derived from malignant endothelial cells comprising a spontaneous tumor in a dog to provide a renewable source of endothelial cells for studies of angiogenesis in malignancy. Pieces of the hemangiosarcoma biopsy were engrafted subcutaneously in a bg/nu/XID mouse allowing the tumor cells to expand in vivo. A cell line, SB-HSA, was derived from the xenograft. SB-HSA cells expressed vascular endothelial growth factor (VEGF) receptors 1 and 2, CD31, CD146, and alpha(v)beta(3) integrin, and produced several growth factors and cytokines, including VEGF, basic fibroblast growth factor, and interleukin (IL)-8 that are stimulatory to endothelial cell growth. These results indicated that the cells recapitulated features of mitotically activated endothelia. In vivo, SB-HSA cells stimulated robust angiogenic responses in mice and formed tumor masses composed of aberrant vascular channels in immunocompromised mice providing novel opportunities for investigating the effectiveness of antiangiogenic agents. Using this model, we determined that IL-12, a cytokine with both immunostimulatory and antiangiogenic effects, suppressed angiogenesis induced by, and tumor growth of, SB-HSA cells. The endothelial cell model we have described offers unique opportunities to pursue further investigations with IL-12, as well as other antiangiogenic approaches in cancer therapy.

Published
2004

66. Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis.

Author

Universitat de Barcelona, Cid Xutglà, M. Cinta, Grant, Derrick S., Hoffman, Gary S., Auerbach, Robert, Fauci, Anthony S., Kleinman, Hynda K., Universitat de Barcelona, Cid Xutglà, M. Cinta, Grant, Derrick S., Hoffman, Gary S., Auerbach, Robert, Fauci, Anthony S., and Kleinman, Hynda K.

Abstract

Angiogenesis is an important process in chronic inflammatory diseases. We observed that sera from patients with systemic vasculitis stimulated angiogenesis in an in vitro model using human umbilical vein endothelial cells cultured on a basement membrane (Matrigel) substrate. After 40% ammonium sulfate precipitation, angiogenic activity remained in the low molecular weight fraction and could be inactivated by heat. SDS-page of serum FPLC fractions exhibiting maximal angiogenic activity demonstrated two prominent species of 45 and 16-20 kD in patients' sera. These bands were much less apparent in sera obtained from control subjects. Amino-terminal sequencing of the 45-kD protein demonstrated that it was haptoglobin. Purified haptoglobin stimulated angiogenesis in a dose-dependent manner. The angiogenic activity of vasculitis patients' sera was partially inhibited by an antihaptoglobin antibody. Furthermore, serum haptoglobin levels in vasculitis patients correlated both with disease and angiogenic activity. Haptoglobin angiogenic activity was confirmed in two in vivo models using an implanted disc and a subcutaneous injection of basement membrane. Stimulation of angiogenesis is a newly recognized biological function of haptoglobin. The increased levels of haptoglobin found in chronic inflammatory conditions may play an important role in tissue repair. In systemic vasculitis, haptoglobin might also compensate for ischemia by promoting development of collateral vessels.

Published
2010

72. Far from full disclosure

Author

Auerbach, Robert D.

Subjects
United States. Federal Open Market Committee -- Records and correspondence, United States. Federal Reserve Board -- Management, Banking, finance and accounting industries, Business
Abstract

The management techniques enforced by the Federal Reserve Board are noted with specific focus on its adamant stance on disclosure to the public regarding records of their most important meetings. There is a rule that places a five-year delay on meetings of the Federal Open Market Committee and the release of transcripts. This practice in the industry is discussed along with its impact.

Published
1999

79. Report from the Society for Biological Therapy and Vascular Biology Faculty of the NCI Workshop on Angiogenesis Monitoring

Author

McDonald, Donald M., primary, Teicher, Beverly A., additional, Stetler-Stevenson, William, additional, Ng, Sylvia S. W., additional, Figg, William D., additional, Folkman, Judah, additional, Hanahan, Douglas, additional, Auerbach, Robert, additional, O’Reilly, Michael, additional, Herbst, Roy, additional, Cheresh, David, additional, Gordon, Michael, additional, Eggermont, Alexander, additional, and Libutti, Steven K., additional

Published
2004
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85. Vascular smooth muscle differentiation of murine stroma

Author

Remy-Martin, Jean-Paul, primary, Marandin, Aliette, additional, Challier, Bruno, additional, Bernard, Gabrielle, additional, Deschaseaux, Marie, additional, Herve, Patrick, additional, Wei, Yanzhang, additional, Tsuji, Takashi, additional, Auerbach, Robert, additional, Dennis, James E., additional, Moore, Kateri A., additional, Greenberger, Joel S., additional, and Charbord, Pierre, additional

Published
1999
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90. Cloning and characterization of developmental endothelial locus-1: An embryonic endothelial cell protein that binds the αvβ3 integrin receptor

Author

Hidai, Chiaki, primary, Zupancic, Thomas, additional, Penta, Kalyani, additional, Mikhail, Adel, additional, Kawana, Masatoshi, additional, Quertermous, Elena E., additional, Aoka, Yoshikazu, additional, Fukagawa, Masafumi, additional, Matsui, Yasuhisa, additional, Platika, Doros, additional, Auerbach, Robert, additional, Hogan, Brigid L.M., additional, Snodgrass, Ralph, additional, and Quertermous, Thomas, additional

Published
1998
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97. Endometrial Ablation: The Facts.

Author

Auerbach, Robert D., Duleba, Antoni I., and Whiteside, Donald C.

Abstract

The article discusses traits related to nonresectoscopic endometrial ablation, a popular treatment for patients suffering from heavy menstrual bleeding (HMB). A hypothermia phenomenon is also illustrated with different studies pertaining to the destruction of endometrium to the level of basal layer. Efficacy of endometrial ablation is also explained and it clarifies that endometrial ablation is a valuable device to treat some women with the symptom of HMB.

Published
2013

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