82 results on '"BORREGO, Luís Miguel"'
Search Results
52. A Revista Portuguesa da SPAIC
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Borrego, Luís Miguel and Couto, Mariana
- Published
- 2017
53. Tinnitus, hearing loss and inflammatory processes in an older Portuguese population.
- Author
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Haider, Haúla F., Ribeiro, Sara F., Martins, Catarina, Ribeiro, Diogo, Trigueiros, Nuno, Szczepek, Agnieszka J., Caria, Helena, Hoare, Derek J., Paço, João, and Borrego, Luís-Miguel
- Subjects
AUDIOMETRY ,STATISTICAL correlation ,FLOW cytometry ,INFLAMMATORY mediators ,INTERLEUKINS ,INTERVIEWING ,MATHEMATICAL statistics ,PSYCHOACOUSTICS ,RESEARCH ,TINNITUS ,TRANSFORMING growth factors-beta ,PARAMETERS (Statistics) ,DATA analysis software ,DESCRIPTIVE statistics ,MANN Whitney U Test ,KRUSKAL-Wallis Test ,ONE-way analysis of variance ,BLOOD ,OLD age - Abstract
Objective: Tinnitus is associated with various conditions such as presbycusis, infectious, autoimmune and many other diseases. Our study aims to identify an association between inflammatory markers and the presence of tinnitus or hearing loss (HL). Design: Exploratory study including a structured interview, complete ENT observation, audiological and inflammatory markers evaluation. Study Sample: Sixty women and 54 men (55 to 75 years) from the Portuguese population, with or without sensory presbycusis and/or tinnitus. Results: IL10 levels were significantly lower in participants with tinnitus than in those without tinnitus. Moreover, TGF-β was lower in older participants (p = 0.034), IL1α was higher in participants with tonal tinnitus (p = 0.033), and IL2 was lower in participants who reported partial or complete residual inhibition (p = 0.019). Additionally, we observed a negative correlation between tinnitus duration and IL10 levels (r= −.281), and between HSP70 levels and tinnitus loudness (r= −.377). TNF-α and HSP70 levels appears to be sensitive to the time when samples were collected (morning or afternoon). Conclusions: The results of our study showing fluctuations in inflammatory markers along the hearing loss process, reinforce the idea that inflammatory mechanisms are involved in hearing loss pathogenesis but also in tinnitus. IL10 levels appear significantly altered in tinnitus but not in hearing loss. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
54. Lower airway flow influences peak nasal inspiratory flow in school-aged children
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Pité, Helena, primary, Pimenta, Lara, additional, Henriques, Ana Cristina, additional, Marques, Inês, additional, Camarinha, Catarina, additional, Lourenço, Ana Verónica, additional, Almeida, Isabel, additional, Borrego, Luís Miguel, additional, and Morais-Almeida, Mário, additional
- Published
- 2018
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55. Immune cell and cytokine patterns in children with type 1 diabetes mellitus undergoing a remission phase: A longitudinal study
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Fitas, Ana Laura, primary, Martins, Catarina, additional, Borrego, Luís Miguel, additional, Lopes, Lurdes, additional, Jörns, Anne, additional, Lenzen, Sigurd, additional, and Limbert, Catarina, additional
- Published
- 2018
- Full Text
- View/download PDF
56. Cow's milk oral immunotherapy in real life: 8-year long-term follow-up study
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Mota, Inês, primary, Piedade, Susana, additional, Gaspar, Ângela, additional, Benito-Garcia, Filipe, additional, Sampaio, Graça, additional, Borrego, Luís Miguel, additional, and Morais-Almeida, Mário, additional
- Published
- 2018
- Full Text
- View/download PDF
57. Pregnancy alters the circulating B cell compartment in atopic asthmatic women, and transitional B cells are positively associated with the development of allergy manifestations in their progeny
- Author
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Martins, Catarina, primary, Lima, Jorge, additional, Nunes, Glória, additional, and Borrego, Luís Miguel, additional
- Published
- 2016
- Full Text
- View/download PDF
58. 6th International Symposium on Molecular Allergology (ISMA)
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Hilger, Christiane, primary, Swiontek, Kyra, additional, Fischer, Jörg, additional, Hentges, François, additional, Lehners, Christiane, additional, Morisset, Martine, additional, Eberlein, Bernadette, additional, Biedermann, Tilo, additional, Ollert, Markus, additional, Wildner, Sabrina, additional, Stemeseder, Teresa, additional, Freier, Regina, additional, Briza, Peter, additional, Lang, Roland, additional, Batanero, Eva, additional, Villalba, Mayte, additional, Lidholm, Jonas, additional, Hawranek, Thomas, additional, Ferreira, Fatima, additional, Brandstetter, Hans, additional, Gadermaier, Gabriele, additional, Moingeon, Philippe, additional, Groeme, Rachel, additional, Bouley, Julien, additional, Bordas, Véronique, additional, Le Mignon, Maxime, additional, Bussières, Laetitia, additional, Lautrette, Aurélie, additional, Mascarell, Laurent, additional, Lombardi, Vincent, additional, Baron-Bodo, Véronique, additional, Chabre, Henri, additional, Batard, Thierry, additional, Nony, Emmanuel, additional, De Amicis, Karine Marafigo, additional, Watanabe, Alexandra Sayuri, additional, Figo, Daniele Danella, additional, Dos Santos-Pinto, José Roberto Aparecido, additional, Palma, Mario Sergio, additional, Castro, Fabio Fernandes Morato, additional, Kalil, Jorge, additional, Wohlschlager, Therese, additional, Ferreira-Briza, Fatima, additional, Santos, Keity Souza, additional, Faber, Margaretha, additional, Van Gasse, Athina, additional, Sabato, Vito, additional, Hagendorens, Margo M., additional, Bridts, Chris H., additional, De Clerck, Luc S., additional, Perales, Araceli Diaz, additional, Ebo, Didier, additional, Zavadakova, Petra, additional, Buchwalder, Aurélie, additional, Rebeaud, Fabien, additional, Märki, Iwan, additional, Gepp, Barbara, additional, Lengger, Nina, additional, Möbs, Christian, additional, Pfützner, Wolfgang, additional, Radauer, Christian, additional, Bohle, Barbara, additional, Galvao, Clovis Eduardo, additional, Santos-Pinto, Jose Roberto Aparecido, additional, Schwager, Christian, additional, Kull, Skadi, additional, Schocker, Frauke, additional, Behrends, Jochen, additional, Becker, Wolf-Meinhard, additional, Jappe, Uta, additional, Mastrorilli, Carla, additional, Tripodi, Salvatore, additional, Caffarelli, Carlo, additional, Asero, Riccardo, additional, Dondi, Arianna, additional, Ricci, Giampaolo, additional, Dascola, Carlotta Povesi, additional, Calamelli, Elisabetta, additional, Di Rienzo Businco, Andrea, additional, Bianchi, Annamaria, additional, Frediani, Tullio, additional, Verga, Carmen, additional, Iacono, Iride Dello, additional, Peroni, Diego, additional, Pingitore, Giuseppe, additional, Bernardini, Roberto, additional, Matricardi, Paolo Maria, additional, Hofer, Heidi, additional, Asam, Claudia, additional, Hauser, Michael, additional, Himly, Martin, additional, Ebner, Christof, additional, Lemoine, Pierrick, additional, Jain, Karine, additional, Abiteboul, Kathy, additional, Arvidsson, Monica, additional, Rak, Sabina, additional, Mota, Inês, additional, Garcia, Filipe Benito, additional, Gaspar, Angela, additional, Arêde, Cristina, additional, Piedade, Susana, additional, Sampaio, Graça, additional, Pires, Graça, additional, Borrego, Luís Miguel, additional, Santa-Marta, Cristina, additional, Morais-Almeida, Mário, additional, Popescu, Florin-Dan, additional, Vieru, Mariana, additional, Secureanu, Florin-Adrian, additional, Fernandes, Rosa Anita Rodrigues, additional, Carrapatoso, Isabel, additional, Gomes, Raquel, additional, Pereira, Celso, additional, Todo-Bom, Ana, additional, De Basoa, María Cecilia Martín Fernández, additional, Regio, Javier Barrios, additional, De Castro Cordova, Juan, additional, Ferreiro, Antón Fernández, additional, Tsilochristou, Olympia, additional, Perna, Serena, additional, Schwarz, Alina, additional, Rohrbach, Alexander, additional, Cappella, Antonio, additional, Hatzler, Laura, additional, Bauer, Carl-Peter, additional, Hoffmann, Ute, additional, Forster, Johannes, additional, Zepp, Fred, additional, Schuster, Antje, additional, D’amelio, Raffael, additional, Wahn, Ulrich, additional, Keil, Thomas, additional, Lau, Susanne, additional, Apoil, Pol André, additional, Mailhol, Claire, additional, Broué-Chabbert, Anne, additional, Juchet, Agnès, additional, Didier, Alain, additional, Carrer, Elodie, additional, Lanot, Thomas, additional, Blancher, Antoine, additional, Kurtaj, Almedina, additional, Hillebrand, Christoph, additional, Fichtinger, Gerda, additional, Danzer, Martin, additional, Gabriel, Christian, additional, Thalhamer, Theresa, additional, Scheiblhofer, Sandra, additional, Thalhamer, Josef, additional, Weiss, Richard, additional, Wolf, Martin, additional, Pichler, Ulrike, additional, Twaroch, Teresa, additional, Yokoi, Hidenori, additional, Takai, Toshiro, additional, Didierlaurent, Alain, additional, Mari, Adriano, additional, Behrendt, Heidrun, additional, Neubauer, Angela, additional, Stolz, Frank, additional, Ferreira, Fátima, additional, Wallner, Michael, additional, Carvalho, Sara, additional, Lourenço, Tatiana, additional, Cosme, Joana, additional, Duarte, Fátima Cabral, additional, Santos, Amélia Spínola, additional, Costa, Ana Célia, additional, Barbosa, Manuel Pereira, additional, Klinglmayr, Eva, additional, Schweidler, Bettina, additional, Lueftenegger, Lisa, additional, Moser, Stephanie, additional, Doppler, Patrick, additional, Oostingh, Gertie J., additional, Bathke, Arne, additional, Zumbach, Joerg, additional, Panzner, Petr, additional, Vachova, Martina, additional, Vlas, Tomas, additional, Maly, Marek, additional, Posa, Daniela, additional, Hofmaier, Stephanie, additional, Stock, Philippe, additional, Grabenhenrich, Linus, additional, Chen, Kuan-Wei, additional, Resch, Yvonne, additional, Vrtala, Susanne, additional, Valenta, Rudolf, additional, Abramidze, Tamar, additional, Lomidze, Nino, additional, Gotua, Maia, additional, Dapkeviciute, Austeja, additional, Einikyte, Ruta, additional, Norkuniene, Jolita, additional, Skrickiene, Laima, additional, Miskiniene, Asta, additional, Kvedariene, Violeta, additional, Schiener, Maximilian, additional, Moreno-Aguilar, Carmen, additional, Pietsch, Gunilla, additional, Intyre, Mareike Mc, additional, Schwarze, Lea, additional, Rußkamp, Dennis, additional, Spillner, Edzard, additional, Darsow, Ulf, additional, Schmidt-Weber, Carsten, additional, Blank, Simon, additional, Longé, Cyril, additional, Brazdova, Andrea, additional, Brunet, Jean-Louis, additional, Schwartz, Claire, additional, Girodet, Bruno, additional, Lavaud, François, additional, Birnbaum, Joelle, additional, Thi, Nhân Pham, additional, Duchateau, Magalie, additional, Chamot-Rooke, Julia, additional, Guilloux, Laurence, additional, Selva, Marie-Ange, additional, Couderc, Rémy, additional, Sénéchal, Hélène, additional, Sutra, Jean-Pierre, additional, Poncet, Pascal, additional, Augustin, Steffen, additional, Pump, Linda, additional, Wald, Martin, additional, Eichhorn, Thomas, additional, Fischer, Frank, additional, Willers, Christoph, additional, Miehe, Michaela, additional, Plum, Melanie, additional, Wolf, Sara, additional, Jabs, Frederic, additional, Raiber, Tim, additional, Bantleon, Frank, additional, Seismann, Henning, additional, Jakob, Thilo, additional, Apostolovic, Danijela, additional, Tran, Anh Thu, additional, Sanchez-Vidaurre, Sara, additional, Velickovic, Tanja Cirkovic, additional, Starkhammar, Maria, additional, Hamsten, Carl, additional, Van Hage, Marianne, additional, Dubiela, Pawel, additional, Humeniuk, Piotr, additional, Pfeifer, Sabine, additional, Bublin, Merima, additional, Borowski, Tomasz, additional, Hoffmann-Sommergruber, Karin, additional, Verschuren, Martie C. M., additional, Bastiaan-Net, Shanna, additional, Depoortere, Defien, additional, Foetisch, Kay, additional, Scheurer, Stephan, additional, Wichers, Harry J, additional, Noij, Theo, additional, Van Uden, Nikki M.E., additional, Vandenberghe, Karel, additional, Wichers, Harry J., additional, Noij, Theo H. M., additional, Roulias, Anargyros, additional, Parigiani, Maria Alejandra, additional, Ahammer, Linda, additional, Grutsch, Sarina, additional, Tollinger, Martin, additional, Moya, Raquel, additional, López-Matas, Mª Angeles, additional, Reyes, Raquel, additional, Carnés, Jerónimo, additional, Larré, Colette, additional, Rogniaux, Hélène, additional, Lupi, Roberta, additional, Denery-Papini, Sandra, additional, Pablos, Isabel Maria, additional, Eichhorn, Stephanie, additional, Machado, Yoan, additional, Park, Jung-Won, additional, Arora, Naveen, additional, Vieths, Stefan, additional, Tanaka, Charlene, additional, Pineau, Florence, additional, Drouet, Martine, additional, Beaudouin, Etienne, additional, Altenbach, Susan, additional, Mameri, Hamza, additional, Brossard, Chantal, additional, Gaudin, Jean Charles, additional, Moneret-Vautrin, Denise Anne, additional, Paty, Evelyne, additional, Tranquet, Olivier, additional, Masci, Stefania, additional, Moneret-Vautrin, Denise-Anne, additional, Petersen, Arnd, additional, Böttger, Marisa, additional, Rennert, Sandra, additional, Krause, Susanne, additional, Ernst, Martin, additional, Gutsmann, Thomas, additional, Bauer, Johann, additional, Lindner, Buko, additional, Koppelman, Stef, additional, Jayasena, Shyamali, additional, Luykx, Dion, additional, Schepens, Erik, additional, De Jong, Govardus, additional, Isleib, Tom, additional, Nordlee, Julie, additional, Baumert, Joe, additional, Taylor, Steve, additional, Maleki, Soheila, additional, Palladino, Chiara, additional, Sirvent, Sofía, additional, Angelina, Alba, additional, Eiwegger, Thomas, additional, Palomares, Oscar, additional, Breiteneder, Heimo, additional, Claude, Mathilde, additional, Bouchaud, Grégory, additional, Bodinier, Marie, additional, Korte, Robin, additional, Bräcker, Julia, additional, Brockmeyer, Jens, additional, Satoh, Rie, additional, Teshima, Reiko, additional, Tscheppe, Angelika, additional, Palmberger, Dieter, additional, Grabherr, Reingard, additional, Raith, Marianne, additional, Sonnleitner, Linda, additional, Zach, Doris, additional, Woroszylo, Konrad, additional, Focke-Tejkl, Margit, additional, Wank, Herbert, additional, Graf, Thorsten, additional, Kuehn, Annette, additional, Swoboda, Ines, additional, Huber, Sara, additional, Gay-Crosier, Fabienne, additional, Polak, Dominika, additional, Nagl, Birgit, additional, Kitzmüller, Claudia, additional, Samadi, Nazanin, additional, Geyeregger, Rene, additional, Jahn-Schmid, Beatrice, additional, Gomez, Ariel, additional, Haka, Jaana, additional, Hattara, Liisa, additional, Heikkinen, Marika, additional, Niemi, Merja H, additional, Rouvinen, Juha, additional, Saviranta, Petri, additional, Mattila, Pekka, additional, Takkinen, Kristiina, additional, Laukkanen, Marja-Leena, additional, Pablos, Isabel, additional, Kastner, Bianca, additional, Silar, Mira, additional, Selb, Julij, additional, Kogovsek, Rok, additional, Kosnik, Mitja, additional, Korosec, Peter, additional, Pestana, Leticia, additional, Melo, Alcinda Campos, additional, Mendes, Ana, additional, Pedro, Maria Elisa, additional, Santos, Maria Conceição Pereira, additional, Bienvenu, Françoise, additional, Goursaud, Claire, additional, Garnier, Lorna, additional, Jacquenet, Sandrine, additional, Degaud, Michaël, additional, Viel, Sébastien, additional, Barre, Annick, additional, Rougé, Pierre, additional, Bienvenu, Jacques, additional, Vitte, Joana, additional, Bensalah, Amel, additional, Cleach, Isabelle, additional, Mousseau, Laurent, additional, Agabriel, Chantal, additional, Liabeuf, Valérie, additional, Birnbaum, Joëlle, additional, Mège, Jean-Louis, additional, Gardner, James, additional, Gandhi, Minal, additional, Kariyawasam, Harsha, additional, Rotiroti, Giuseppina, additional, Regateiro, Frederico, additional, Faria, Emília, additional, Schmid, Johannes Martin, additional, Dahl, Ronald, additional, Hoffmann, Hans Juergen, additional, Pestana, Letícia, additional, Silva, Diana, additional, Vieira, Teresa, additional, Pereira, Ana Maria, additional, Moreira, André, additional, Delgado, Luís, additional, Prates, Sara, additional, Alves, Cátia, additional, Finelli, Elena, additional, Pinto, Paula Leiria, additional, Cardoso, Bárbara Kong, additional, Cruz, Cíntia, additional, Semedo, Filipa, additional, Tomaz, Elza, additional, Inácio, Filipe, additional, Maity, Santanu, additional, Baricevic-Jones, Ivona, additional, Marsh, Justin T., additional, Johnson, Phil E., additional, Balasundaram, Anuradha, additional, Hope, Anya-May, additional, Taekema, Aafke, additional, Simpson, Angela, additional, Semic-Jusufagic, Aida, additional, Clare Mills, E. N., additional, Nelly, Gourdon Dubois, additional, Laetitia, Sellam, additional, Bruno, Pereira, additional, Elodie, Michaud, additional, Khaled, Messaoudi, additional, Bertrand, Evrard, additional, Jean-Luc, Fauquert, additional, Goodman, Richard E., additional, Plata, Elena Rodríguez, additional, Amaral, Luis, additional, Bartolomé, Borja, additional, Coimbra, Alice, additional, Placido, Jose L, additional, Ganea, Carmen Saviana, additional, Costello, Carol Ann, additional, Sorensen, Martin, additional, Mills, Clare, additional, Rogers, Adrian, additional, Otherhals, Aage, additional, Kalic, Tanja, additional, Ellinger, Isabella, additional, Waltl, Eva, additional, Niederberger-Leppin, Verena, additional, Szczepankiewicz, Dawid, additional, Pruszynska-Oszmalek, Ewa, additional, Skrzypski, Marek, additional, Nowak, Krzysztof W., additional, Szczepankiewicz, Aleksandra, additional, Jang, Gwang-Cheon, additional, Markovic, Iva, additional, Borowski, Andreas, additional, Vetter, Tina, additional, Wohlmann, Andreas, additional, Kuepper, Michael, additional, Friedrich, Karlheinz, additional, Gracia, Ibon Eguiluz, additional, Bosco, Anthony, additional, Dollner, Ralph, additional, Melum, Guro Reinholt, additional, Jones, Anya C, additional, Lexberg, Maria, additional, Holt, Patrick G, additional, Bækkevold, Espen Sønderaal, additional, Jahnsen, Frode Lars, additional, Sobkowiak, Paulina, additional, Rachel, Marta, additional, Narozna, Beata, additional, Jenerowicz, Dorota, additional, Swiatowy, Witold, additional, Breborowicz, Anna, additional, Nestelbacher, Reinhard, additional, and Fukui, Hiroyuki, additional
- Published
- 2016
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59. A dedução de perdas de sociedades sob regimes de recuperação como auxílio de Estado
- Author
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Borrego, Luís Miguel Perdigão and Dourado, Ana Paula
- Subjects
Benefícios fiscais ,Auxílio estatal ,União Europeia ,Harmonização fiscal ,Teses de mestrado - 2014 ,Recuperação de empresas ,Concorrência fiscal - Abstract
Submitted by Maria João Antunes (mariajoao@fd.ul.pt) on 2015-02-25T14:43:44Z No. of bitstreams: 1 ulfd128682_tese.pdf: 59011869 bytes, checksum: 249cc444e8592356cb7b3847b01e73b3 (MD5) Made available in DSpace on 2015-02-25T14:43:52Z (GMT). No. of bitstreams: 1 ulfd128682_tese.pdf: 59011869 bytes, checksum: 249cc444e8592356cb7b3847b01e73b3 (MD5) Previous issue date: 2014-12-18
- Published
- 2014
60. role of occupational Aspergillus exposure in the development of diseases.
- Author
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Sabino, Raquel, Veríssimo, Cristina, Viegas, Carla, Viegas, Susana, Brandão, João, Alves-Correia, Magna, Borrego, Luís-Miguel, Clemons, Karl V, Stevens, David A, and Richardson, Malcolm
- Abstract
Aspergillus spp. have a high nutritional versatility and good growth on a large variety of construction materials. They also colonize soil or food, but decaying vegetation is their primary ecological niche. Therefore, exposure to fungi may occur at home, during hospitalization, during specific leisure activities, or at the workplace. The development of Aspergillus infections depends on the interplay between host susceptibility and the organism. Environments with high counts of fungal elements (conidia, hyphal fragments and others), high levels of bioarerosols, and elevated concentrations of mycotoxins or other volatile organic compounds should be considered as potential hazards, since they may present a risk to the exposed person. Rural tasks as well as work related to wood and food industries, poultries, swineries, waste handling plants, and other occupational environments involving contaminated organic material are among the ones posing higher respiratory risks to the workers. This paper presents a review of several studies related to occupational and indoor exposure to Aspergillus, potential health effects related to that exposure, and associated exposure assessment procedures. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
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61. Over-The-Counter Products and Food Allergy in Children
- Author
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Borrego, Luís Miguel, primary
- Published
- 2016
- Full Text
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62. Characterization of B cells in healthy pregnant women from late pregnancy to post-partum: a prospective observational study
- Author
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Lima, Jorge, primary, Martins, Catarina, additional, Leandro, Maria J., additional, Nunes, Glória, additional, Sousa, Maria-José, additional, Branco, Jorge C., additional, and Borrego, Luís-Miguel, additional
- Published
- 2016
- Full Text
- View/download PDF
63. Avaliação da função respiratória: Comparação entre valores de referência percentuais fixos e o 5.º percentil para diagnóstico de obstrução das vias aéreas
- Author
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Borrego, Luís Miguel, Couto, Mariana, Almeida, Isabel, Pimenta, Lara, Matos, Sara, and Morais-Almeida, Mário
- Subjects
diagnostic tests ,função respiratória ,reference standards ,bronchial obstruction ,obstrução brônquica ,Asthma ,Asma ,testes diagnósticos ,valores de referência - Abstract
Introdução: Têm sido utilizados critérios fixos para avaliação funcional de doentes com patologia respiratória. É actualmente recomendado pelas orientações internacionais a utilização preferencial do limite inferior (LLN) ou superior da normalidade (inferior ou superior ao 5.º percentil). Objectivo: Comparar os resultados das provas de função respiratória (PFR), utilizando os valores percentuais fixos versus 5.º percentil (método de referência) como limites da normalidade, no diagnóstico funcional de obstrução das vias aéreas. Métodos: Análise retrospectiva dos registos de PFR (espirometria e pletismografia corporal) efectuados pelos autores em 2011. Foi avaliada a concordância entre os dois métodos na amostra global, sendo os doentes distribuídos por faixas etárias.Posteriormente foram seleccionadas as PFR com razão FEV1/VC (volume expiratório máximo no 1.º segundo/capacidade vital) < LLN. Nestas, foram analisados os parâmetros FEV1, FVC (capacidade vital forçada), TLC (capacidade pulmonar total) e RV (volume residual) quando considerados o 5.º percentil versus valores percentuais fixos. A análise estatística for realizada com SPSS 20.0, com recurso ao teste Kappa de Cohen. Resultados: Em 2011, 1358 indivíduos realizaram PFR. Foram excluídos 8 por dados incompletos. O grau de concordância entre os dois critérios foi Kappa = 0,655 ± 0,035. Entre os 124 doentes que apresentavam obstrução pelo LLN, 32 (26%) tiveram um teste normal pelo cut-off de 0,70, pelo que seriam erradamente subdiagnosticados. Este facto apenas se verificou nas faixas etárias mais jovens, enquanto nos grupos etários mais idosos se observou uma elevada taxa de sobrediagnóstico (51 indivíduos - 36%). Entre os doentes com obstrução, a concordância para os restantes parâmetros foi boa, excepto para a hiperinsuflação diagnosticada por TLC. Conclusão: A utilização de valores percentuais fixos para diagnóstico de obstrução resulta em elevada taxa de subdiagnóstico em idades jovens e sobrediagnóstico em idades avançadas. Introduction: Fixed criteria have been classically used in the functional characterization of patients with respiratory diseases. International guidelines actually recommend the preferential use of the lower (LNN) or upper limit of normality (below or above the 5th percentile). Objective: To compare the results of lung function (LF) obtained in clinical practice for diagnosis of airway obstruction, using fixed percentage values versus the 5th percentile (the reference standard) as normality limits. Methods: Retrospective analysis of LF (spirometry and body plethysmography) performed in 2011 by the authors. It has been evaluated the concordance of both methods in the global sample, and divided by age groups. Those with criteria for airway obstruction considering the FEV1/VC (forced expiratory volume in one second / vital capacity) ratio < LLN were selected and among these, we analyzed FEV1, FVC (forced vital capacity), TLC (total lung capacity) and RV (residual volume) considering the 5th percentile and the fixed percentage values. Statistical analysis was performed with SPSS 20.0, using Cohen’s Kappa test. Results: During 2011, 1358 subjects underwent LF; 8 were excluded due to incomplete data. Overall, the agreement between the two criteria was kappa = 0.655 ± 0.035. Among the 124 patients who had obstruction diagnosed by LLN, 32 (26%) had a normal test with the 0.70 cut -off, and would be wrongly underdiagnosed. This occurred only in younger age groups, while in older ones a high rate of overdiagnosis (51 subjects - 36%) was observed. Among patients with airway obstruction, the agreement of the 2 criteria for the remaining parameters was good, except for inflation diagnosed with TLC. Conclusion: Using fixed percentage criteria for the diagnosing airway obstruction leads to a high rate of underdiagnosis in younger and overdiagnosis in older ages.
- Published
- 2013
64. Segurança da imunoterapia específica em pauta ultrarápida utilizando extractos alergénicos modificados em idade pediátrica
- Author
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Arêde, Cristina, Sampaio, Graça, Borrego, Luís Miguel, and Morais-Almeida, Mário
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Aeroallergens ,paediatrics ,safety ,criança ,imunoterapia específica ,allergoids ,Aeroalergénios ,pauta ultrarápida ,segurança ,alergóides ,ultrarush ,specific immunotherapy - Abstract
Introdução: A indução da imunoterapia específica (IE) subcutânea (SC) com extractos alergénicos convencionais, para além da sua morosidade, pode associar-se à ocorrência de reacções adversas. Recentemente foi documentada a eficácia e a segurança dos extractos modificados, como os alergóides, com a indução efectuada em pautas aceleradas. No entanto, são escassos os estudos que avaliem a sua segurança em crianças. Objectivo: Avaliar o perfil de segurança, em idade pediátrica, da IE com extractos modificados, despigmentados, polimerizados com gluteraldeído, usando uma pauta ultrarápida de 30 minutos para alcançar a manutenção. Material e métodos: Foram incluídas todas as crianças submetidas a tratamento com IE SC com extractos alergénicos modificados de ácaros ou de pólenes, com fase de indução em pauta ultrarápida, durante os últimos 5 anos. Foram registados o tipo de reacções adversas e a sua abordagem. Resultados: Foram estudadas 100 crianças (57 do género masculino) com uma média etária de 11,6 anos (5 a 18 anos, desvio padrão de 3,3), todas com rinite alérgica persistente moderada a grave, com ou sem conjuntivite alérgica, asma e eczema atópico, sensibilizadas a ácaros e/ou a pólenes. À excepção de uma criança, todas alcançaram a dose de manutenção no dia da indução, sendo de 199 o número total de injecções SC durante a pauta ultrarápida. Ocorreram 21 reacções adversas locais em 11 doentes, 11 imediatas e 10 tardias; tiveram relevância clínica 1 imediata e 4 tardias. Foram registadas reacções sistémicas em 2 casos, ambas imediatas e ligeiras. Durante a fase de manutenção foi administrado um total de 1347 injecções, tendo ocorrido 4 reacções adversas em 4 doentes, 3 locais e 1 sistémica ligeira. Conclusões: A pauta ultrarápida, sem pré -medicação, prescrita e administrada por imunoalergologistas, é uma alternativa segura para ser usada em crianças alérgicas na fase de indução da IE usando alergóides polimerizados. Na fase de manutenção comprovou-se igualmente uma elevada segurança. Introduction: Conventional subcutaneous immunotherapy with allergenic extracts, besides its slowness, has been shown to be potentially associated with adverse reactions. In recent studies, it has been demonstrated that using modified extracts, namely allergoids, is safe and effective, particularly on accelerated schedules, such as ultrarush. However, studies assessing its safety in children are scarce. Objective: To evaluate the safety profile in a pediatric population, using standardized modified allergen extracts, depigmented, polymerized with glutaraldehyde, in an ultrarush protocol to reach the maintenance dose. Material and methods: We included in the present study all children undergoing treatment with subcutaneous immunotherapy modified allergen extract of mites or pollens, that made a ultrarush induction phase during the last five years. We recorded the type of adverse reactions and the clinical approach. Results: We studied 100 children (57 male) with a mean age of 11.6 years (5 to 18 years, standard deviation 3.3), all with persistent moderate to severe rhinitis with or without allergic conjunctivitis, asthma and atopic eczema, sensitized to mites and/or pollens. All reached the maintenance dose in the first day, except one child, and 199 was the total number of injections during ultrarush protocol. There were 21 local adverse reactions in 11 patients, 11 immediate and 10 delayed; have clinical relevance 1 immediate and 4 delayed. Systemic reactions were recorded in two cases, both immediate and mild. A total of 1347 subcutaneous injections were administered during maintenance phase. There were 4 adverse reactions in 4 patients, 3 local and 1 mild systemic. Conclusions: The ultrarush protocol, without premedication, prescribed by allergists, is a safe alternative for use in children in the induction phase of subcutaneous immunotherapy using allergoid polymerized extracts. During the maintenance phase the extract was also highly safe.
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- 2013
65. Management of childhood urticaria
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Pite, Helena, Wedi, Bettina, Borrego, Luís Miguel, Kapp, Alexander, Raap, Ulrike, and Centro de Estudos de Doenças Crónicas (CEDOC)
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Urticaria ,immune system diseases ,Pruritus ,Diagnosis ,Disease management ,Antihistamines ,Therapy ,Dermatology ,Children - Abstract
Urticaria, defined by the presence of wheals and/or angio edema, is a common condition in children, prompting parents to consult physicians. For its successful management, paediatric-specific features must be taken into account, regarding the identifcation of eliciting triggers and pharmacological therapy. This review systematically discusses the current best-available evidence on spontaneous acute and chronic urticaria as well as physical and other urticaria types in children. Potential underlying causes, namely infections, food and drug hypersensitivity, autoreactivity and autoimmune or other conditions, and eliciting stimuli are considered, with practical recommendations for specific diagnostic approaches. Second-generation antihistamines are the mainstay of pharmacological treatment aimed at relief of symptoms, which require dose adjustment for pae diatric use. Other therapeutic interventions are also discussed. In addition, unmet needs are highlighted, aiming to promote research into the paediatric population, ultimately aiming at the effective management of childhood urticaria. publishersversion published
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- 2013
66. Association between memory B-cells and clinical and immunological features of primary Sjögren’s syndrome and Sicca patients.
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Martins, Catarina, Nunes, Glória, Lopes, Teresa, Borrego, Luís-Miguel, Barcelos, Filipe, Branco, Jaime, Papoila, Ana, Geraldes, Carlos, Cardigos, Joana, Alves, Nuno, and Vaz-Patto, José
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SJOGREN'S syndrome ,FLOW cytometry ,B cells ,DIAGNOSIS ,AUTOIMMUNITY ,CLINICAL trials - Abstract
B-cells play a pivotal role in primary Sjögren’s syndrome (pSS) pathogenesis. We aim to (1) evaluate the distribution of B-lymphocyte subpopulations in pSS and Sicca patients, (2) establish cut-off points that discriminate pSS from controls, (3) evaluate the association between memory B-cells and phenotypic features in pSS. We included 57 pSS patients, 68 Sicca and 24 healthy controls. Circulating B-cells were characterized by flow cytometry as naïve and memory subsets and classified from Bm1 to Bm5. Compared to controls, pSS patients had lower percentages (29.5 vs 44.4%) and absolute numbers (47 vs 106 cells/µl) of memory B-cells. Through ROC curves, a cut-off of ≤ 58 total memory B-cells/µl yielded a specificity of 0.88 and a sensitivity of 0.60 for pSS, and was met by 59.6% of pSS patients, 38.8% of Sicca and 12.5% of controls. A cut-off of < 23.5 Switched-memory B-cells/µl yielded a specificity of 0.88 and a sensitivity of 0.54 and was met by 54.4% of pSS patients, 37.3% of Sicca and 12.5% of controls. In pSS, lower total memory B-cells count was associated with longer disease duration (14.3 vs 8.1 years, p = 0.006) and more active disease profile, as evaluated by the European League Against Rheumatism (EULAR) Sjögren’s Syndrome Disease Activity Index (ESSDAI) (3.1 vs 1.4, p = 0.043). Decreased numbers of memory B-cells clearly discriminated pSS from controls and can also have prognostic value. It remains to be clarified whether Sicca patients with decreased memory B-cells represent pSS and if B-cell profiling could help in the diagnosis of pSS. [ABSTRACT FROM AUTHOR]
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- 2018
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67. Translation and cultural adaptation to Portuguese of Food Allergy Quality of Life Questionnaire‐Parent Form (FAQLQ‐PF)
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Couto, Mariana, primary, Silva, Diana, additional, Piedade, Susana, additional, Dunn Galvin, Audrey, additional, Flokstra ‐ de Blok, Bertine, additional, Borrego, Luís Miguel, additional, and Morais‐Almeida, Mário, additional
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- 2015
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68. Crianças com sibilância recorrente: estudo de função respiratória, avaliação imunológica e polimorfismos genéticos
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Borrego, Luís Miguel Nabais and Caetano, Joaquim António Machado
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Imunologia ,Respiratory Insufficiency ,Infant ,Child ,Respiratory Tract Infections - Abstract
RESUMO Nos últimos anos têm sido identificados vários factores de risco para asma brônquica em crianças com sibilância recorrente, não se encontrando clara a importância da avaliação funcional respiratória nestas crianças. De igual modo, têm sido documentados resultados contraditórios na avaliação imunológica das populações de células reguladoras bem como na expressão de polimorfismos para a asma. O objectivo deste estudo consistiu na avaliação e comparação de parâmetros de avaliação funcional respiratória, imunológica e de polimorfismos genéticos em crianças entre 8 e 20 meses de idade, com três ou mais episódios de sibilância (n=50), sem qualquer terapêutica anti-inflamatória prévia, diagnosticados por um médico, com e sem factores de risco para asma brônquica (história de asma parental ou história pessoal de eczema ou pelo menos dois dos seguintes: história pessoal de rinite alérgica, sibilância fora do contexto infeccioso e contagem de eosinófilos no sangue periférico > 4%), comparados com um grupo controlo (n=30). Nestas crianças foram efectuadas provas de função respiratória em volume corrente e em volume aumentado através de técnicas de compressão torácica, avaliação de populações celulares por citometria de fluxo, expressão de citocinas por mARN em culturas de células estimuladas com PMA (leitura às 24 horas) e com extractos de ácaros do pó doméstico (leitura ao 7º dia) e expressão de polimorfismos para alguns genes associados a asma (ADAM 33, DPP10, GPRA). Na comparação entre as crianças com sibilância recorrente em relação ao grupo controlo foram observadas reduções significativas nos Z-scores para FVC (diferença média [95% IC]: -0,7 [-1,2; -0,1], p=0,01), FEV0.5 (-1,0 [-1,5; -0,5], p=0,0001), FEF75 (-0,6 [-1,0; -0,2], p=0,0001) e FEF25-75 (-0,8 [-1,2; -0,4], p=0,0001), bem como valores significativamente mais baixos para a quantificação do número absoluto de CD4+CD25forte (-47,9 [-89,6; -6,1], p=0,03), do número absoluto e percentual de CD4+CD25+CTLA-4 (p=0,0001) e da expressão de CTLA-4 (p=0,03) e IFN- (p=0,04) nas culturas com extractos de ácaros. As crianças sibilantes com alto risco para asma tinham, em relação ao grupo sem factores de risco, Z-scores significativamente mais baixos para FVC (-0,7 [-1,4; -0,04], p=0,04) e FEF25-75 (-0,6 [-1,2; -0,1], p=0,03),2 valores significativamente inferiores do número absoluto das populações CD4+CD25+ (-118,8 [-210,0; -27,5], p=0,01) e CD4+CD25forte (-56,2 [-109,9; -2,5], p=0,04) e ainda uma expressão diminuída de IFN- (p=0,03) em culturas de células estimuladas com extractos de ácaros. Foram encontradas diferenças na expressão de polimorfismos para os genes GPRA e ADAM 33, não sendo possível tecer extrapolações pelo reduzido número de crianças em estudo. As crianças com sibilância recorrente e alto risco de asma apresentavam alterações na avaliação funcional respiratória, bem como no número absoluto de populações celulares com função reguladora e na expressão de IFN- em culturas celulares estimuladas com extractos de ácaros. Estes resultados realçam a eventual importância da avaliação das provas de função respiratória e de parâmetros imunológicos, em crianças com sibilância recorrente e alto risco clínico para asma, nos primeiros dois anos de vida, apesar da sua controversa aplicabilidade individual. O seguimento prospectivo destas crianças poderá aferir o seu valor preditivo para asma em idade escolar.
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- 2008
69. Development process and cognitive testing of CARATkids - Control of Allergic Rhinitis and Asthma Test for children
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Borrego, Luís Miguel, primary, Fonseca, João Almeida, additional, Pereira, Ana Margarida, additional, Pinto, Vera Reimão, additional, Linhares, Daniela, additional, and Morais-Almeida, Mário, additional
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- 2014
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70. Lung function evaluation: comparing fixed percentage reference values vs. the 5th percentile in the diagnosis of airway obstruction
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Borrego, Luís Miguel, primary, Couto, Mariana, additional, Almeida, Isabel, additional, Pimenta, Lara, additional, Matos, Sara, additional, and Morais-Almeida, Mário, additional
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- 2013
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71. Monoclonal IgG Kappa gammopathy previous to hematopoietic stem cell transplantation in an infant with severe combined immunodeficiency
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Simão, Inês, primary, Cordeiro, Ana Isabel, additional, Borrego, Luís Miguel, additional, Martins, Catarina, additional, Neves, Conceição, additional, and Neves, João Farela, additional
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- 2012
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72. Células reguladoras
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Borrego, Luís Miguel, primary, Rosa, Sónia, additional, Algueró, Cármen, additional, Trindade, Hélder, additional, and Pinto, José Rosado, additional
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- 2007
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73. 4th Pediatric Allergy and Asthma Meeting (PAAM)
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Yavuz, S. Tolga, Koc, Ozan, Gungor, Ali, Gok, Faysal, Hawley, Jessica, O’Brien, Christopher, Thomas, Matthew, Brodlie, Malcolm, Michaelis, Louise, Mota, Inês, Gaspar, Ângela, Piedade, Susana, Sampaio, Graça, Dias, José Geraldo, Paiva, Miguel, Morais-Almeida, Mário, Madureira, Cristina, Lopes, Tânia, Lopes, Susana, Almeida, Filipa, Sequeira, Alexandra, Carvalho, Fernanda, Oliveira, José, Gay-Crosier, Fabienne, Nenciu, Ioana-Valentina, Nita, Andreia Florina, Ulmeanu, Alexandru, Oraseanu, Dumitru, Zapucioiu, Carmen, Machinena, Adrianna, Sánchez, Olga Domínguez, Lozano, Montserrat Alvaro, Feijoo, Rosa Jiménez, Blasco, Jaime Lozano, Gibert, Mònica Piquer, Muñoz, Mª Teresa Giner, da Costa, Marcia Dias, Martín, Ana Maria Plaza, Yilmaz, Ebru Arik, Cavkaytar, Özlem, Buyuktiryaki, Betul, Soyer, Ozge, Sackesen, Cansin, Netting, Merryn, El-Merhibi, Adaweyah, Gold, Michael, Quinn, Patrick, Penttila, Irmeli, Makrides, Maria, Giavi, Stavroula, Muraro, Antonella, Lauener, Roger, Mercenier, Annick, Bersuch, Eugen, Montagner, Isabella M., Passioti, Maria, Celegato, Nicolò, Summermatter, Selina, Nutten, Sophie, Bourdeau, Tristan, Vissers, Yvonne M., Papadopoulos, Nikolaos G., van der Kleij, Hanneke, Warmenhoven, Hans, van Ree, Ronald, Pieters, Raymond, Opstelten, Dirk Jan, van Schijndel, Hans, Smit, Joost, Fitzsimons, Roisin, Timms, Victoria, Du Toit, George, Kaya, Guven, Gulec, Mustafa, Saldir, Mehmet, Sener, Osman, Hassan, Nagwa, Shaaban, Hala, El-Hariri, Hazem, Mahfouz, Ahmed Kamel Inas E., Gabor, Papp, Gabor, Biro, Csaba, Kovacs, Chawes, Bo, Bønnelykke, Klaus, Stokholm, Jakob, Heickendorff, Lene, Brix, Susanne, Rasmussen, Morten, Bisgaard, Hans, Hallas, Henrik Wegener, Arianto, Lambang, Pincus, Maike, Keil, Thomas, Reich, Andreas, Wahn, Ulrich, Lau, Susanne, Grabenhenrich, Linus, Fagerstedt, Sara, Hesla, Helena Marell, Johansson, Emelie, Rosenlund, Helen, Mie, Axel, Scheynius, Annika, Alm, Johan, Esparza-Gordillo, Jorge, Matanovic, Anja, Marenholz, Ingo, Bauerfeind, Anja, Rohde, Klaus, Nemat, Katja, Lee-Kirsch, Min-Ae, Nordenskjöld, Magnus, Winge, Marten C.G., Krüger, Renate, Beyer, Kirsten, Kalb, Birgit, Niggemann, Bodo, Hübner, Norbert, Cordell, Heather J., Bradley, Maria, Lee, Young-Ae, Gough, Hannah, Schramm, Dirk, Beschorner, John, Schuster, Antje, Bauer, Carl-Peter, Forster, Johannes, Zepp, Fred, Bergmann, Renate, Bergmann, Karl, Garcia, Filipe Benito, Santos, Natacha, Pité, Helena, Papadopoulou, Athina, Mermiri, Despina, Xatziagorou, Elpida, Tsanakas, Ioannis, Lampidi, Stavroula, Priftis, Kostas, Fuertes, Elaine, Markevych, Iana, Bowatte, Gayan, Gruzieva, Olena, Gehring, Ulrike, Becker, Allan, Berdel, Dietrich, Brauer, Michael, Carlsten, Chris, Hoffmann, Barbara, Kozyrskyj, Anita, Lodge, Caroline, Pershagen, Göran, Wijga, Alet, Joachim, Heinrich, Zivkovic, Zorica, Djuric-Filipovic, Ivana, Jocić-Stevanovic, Jasmina, Zivanovic, Snežana, Taka, Styliani, Kokkinou, Dimitra, Papakonstantinou, Aliki, Stefanopoulou, Panagiota, Georgountzou, Anastasia, Maggina, Paraskevi, Stamataki, Sofia, Papaevanggelou, Vassiliki, Andreakos, Evangelos, Gibert, Monica Piquer, Spera, Adriana Machinena, Deliu, Matea, Belgrave, Danielle, Simpson, Angela, Custovic, Adnan, Marques, João Gaspar, Carreiro-Martins, Pedro, Belo, Joana, Serranho, Sara, Peralta, Isabel, Neuparth, Nuno, Leiria-Pinto, Paula, Vazquez-Ortiz, Marta, Pascal, Mariona, Plaza, Ana Maria, Juan, Manel, Paparo, Lorella, Nocerino, Rita, Aitoro, Rosita, Langella, Ilaria, Amoroso, Antonio, Amoroso, Alessia, Di Scala, Carmen, Berni Canani, Roberto, Maity, Santanu, Rotiroti, Giuseppina, Gandhi, Minal, Jonsson, Karin, Ljung, Annika, Hesselmar, Bill, Adlerbert, Ingegerd, Brekke, Hilde, Johansen, Susanne, Wold, Agnes, Sandberg, Ann-Sofie, Nordlund, Björn, Lundholm, Cecilia, Ullemar, Villhelmina, van Hage, Marianne, Örtqvist, Anne, Almqvist, Catarina, Selby, Anna, Grimshaw, Kate, Clausen, Michael, Dubakiene, Ruta, Fiocchi, Alessandro, Kowalski, Marek, Papadopoulos, Nikos, Reche, Marta, Sigurdardottir, Sigurveig, Sprikkleman, Aline, Xepapadaki, Paraskevi, Mills, Clare, Roberts, Graham, Neto, Herberto Jose Chong, Wandalsen, Gustavo Falbo, Bianca, Ana Carolina Dela, Aranda, Carolina, Rosário, Nelson Augusto, Solé, Dirceu, Mallol, Javier, Marcos, Luis García, Banic, Ivana, Rijavec, Matija, Plavec, Davor, Korosec, Peter, Turkalj, Mirjana, Bozicevic, Alen, De Mieri, Maria, Hamburger, Matthias, Holley, Simone, Morris, Ruth, Mitchell, Frances, Knibb, Rebecca, Latter, Susan, Liossi, Christina, Hassan, Mostafa M. M., Barman, Malin, Sandin, Anna, Posa, Daniela, Perna, Serena, Hoffmann, Ute, Chen, Kuan-Wei, Resch, Yvonne, Vrtala, Susanne, Valenta, Rudolf, Matricardi, Paolo Maria, Tsilochristou, Olympia, Rohrbach, Alexander, Cappella, Antonio, Hofmaier, Stephanie, Hatzler, Laura, D’Amelio, Raffaele, Björkander, Sophia, Johansson, Maria A., Lasaviciute, Gintare, Sverremark-Ekström, Eva, Rüschendorf, Franz, Strachan, David P., Spycher, Ben D., Baurecht, Hansjörg, Margaritte-Jeannin, Patricia, Sääf, Annika, Kerkhof, Marjan, Ege, Markus, Baltic, Svetlana, Matheson, Melanie C., Li, Jin, Michel, Sven, Ang, Wei Q., McArdle, Wendy, Arnold, Andreas, Homuth, Georg, Demenais, Florence, Bouzigon, Emmanuelle, Söderhäll, Cilla, de Jongste, Johan C., Postma, Dirkje S., Braun-Fahrländer, Charlotte, Horak, Elisabeth, Ogorodova, Ludmila M., Puzyrev, Valery P., Bragina, Elena Yu, Hudson, Thomas J., Morin, Charles, Duffy, David L., Marks, Guy B., Robertson, Colin F., Montgomery, Grant W., Musk, Bill, Thompson, Philip J., Martin, Nicholas G., James, Alan, Sleiman, Patrick, Toskala, Elina, Rodriguez, Elke, Fölster-Holst, Regina, Franke, Andre, Lieb, Wolfgang, Gieger, Christian, Heinzmann, Andrea, Rietschel, Ernst, Cichon, Sven, Nöthen, Markus M., Pennell, Craig E., Sly, Peter D., Schmidt, Carsten O., Schneider, Valentin, Heinig, Matthias, Holt, Patrick G., Kabesch, Michael, Weidinger, Stefan, Hakonarson, Hakon, Ferreira, Manuel AR, Laprise, Catherine, Freidin, Maxim B, Genuneit, Jon, Koppelman, Gerard H, Melén, Erik, Dizier, Marie-Hélène, John Henderson, A., Lee, Young Ae, González-Delgado, Purificacion, Caparrós, Esther, Clemente, Fernando, Cueva, Begoña, Moreno, Victoria M., Carretero, Jose Luis, Fernández, Javier, Swan, Kate, Gopi, Mudiyur, Smith, Tim, Ramesh, Edara, Sadasivam, Arun, Arêde, Cristina, Borrego, Luís Miguel, Pires, Graça, Santa-Marta, Cristina, Brand, Stephanie, Stein, Karina, Heine, Holger, Kauth, Marion, Rolfsjord, Leif Bjarte, Bakkeheim, Egil, Skjerven, Håvard Ove, Carlsen, Kai-Håkon, Hunderi, Jon Olav, Berents, Teresa Løvold, Mowinckel, Petter, Lødrup Carlsen, Karin C., Munzel, Ullrich, Berger, William, Valiente, Román, Vozmediano, Valvanera, Lukas, John C., Rodríguez, Mónica, Guarnaccia, Sebastiano, Vitale, Luigi, Pluda, Ada, D’Agata, Emanuele, Colombo, Denise, Felici, Stefano, Gretter, Valeria, Facchetti, Susanna, Pecorelli, Gaia, Quecchia, Cristina, Guibas, George, Spandou, Evangelia, Megremis, Spyridon, West, Peter, Papadopoulos, Nikolaos, Rufo, João Cavaleiro, Madureira, Joana, Paciência, Inês, Aguiar, Lívia, Padrão, Patrícia, Pinto, Mariana, Delgado, Luís, Moreira, Pedro, Teixeira, João Paulo, Fernandes, Eduardo Oliveira, Moreira, André, Dominguez, Adriana Izquierdo, Valero, Antonio, Mullol, Joaquim, Del Cuvillo, Alfonso, Montoro, Javier, Jauregui, Ignacio, Bartra, Joan, Davila, Ignacio, Ferrer, Marta, Sastre, Joaquin, Martins, Catarina, Lima, Jorge, Leandro, Maria José, Nunes, Glória, Branco, Jorge Cunha, Trindade, Hélder, Borrego, Luis Miguel, Conkar, Secil, Kilic, Mehtap, Aygun, Canan, Sancak, Recep, Tagalaki, Eleni, Banos, Lambros, Vlachou, Anna, Giannoula, Fotini, Pavlakou, Marina, Kryoni, Maria, Makris, Kostas, Lazova, Snezhina, Petrova, Guergana, Miteva, Dimitrinka, Perenovska, Penka, Klyucharova, Aliya, Skorohodkina, Olesya, Koumaki, Dimitra, Manousaki, Alkisti, Agrapidi, Maria, Iatridou, Lida, Eruk, Omima, Myridakis, Konstantinos, Manousakis, Emmanouil, Koumaki, Vasiliki, Dimou, Maria, Ingemansson, Maria, Hedlin, Gunilla, Pastor, Nitida, de Boissieu, Delphine, Vanderhoof, Jon, Moore, Nancy, Maditz, Kaitlin, Mehdi, Adeli, Elhassan, Shaza, Beck, Carolin, Al-Hammadi, Ahmed, Maris, Ioana, O’Sullivan, Ronan, Hourihane, Jonathan, Raptis, George, DunnGalvin, Audrey, Greenhawt, Matthew, Venter, Carina, O’Regan, Evelyn, Cronin, Duncan, O’Reilly, Anna, Abdelaziz, Foued, Khelifi-Touhami, Dounia, Selim, Nihad, Khelifi-Touhami, Tahar, Merida, Pablo, Plaza, Ana Mª, Castellanos, Juan Heber, Lozano, Jaime, Dominguez, Olga, Piquer, Monica, Jimenez, Rosa, Giner, Mª Teresa, Kakleas, Konstantinos, Joishy, Manohar, Maskele, Wendmu, Jenkins, Huw R., Escarrer, Mercedes, Madroñero, Agustín, Guerra, Maria Teresa, Julia, Juan Carlos, Cerda, Juan Carlos, Contreras, Javier, Tauler, Eulalia, Vidorreta, Maria Jesus, Rojo, Ana, Del Valle, Silvia, Flynn, Niamh, Foley, Gary, Harmon, Carol, Fitzsimons, John, Baynova, Krasimira, Del Robledo, Ávila Maria, Marina, Labella, Cortes, Aaron, Sciaraffia, Alicia, Castillo, Angela, Juel-Berg, Nanna, Hansen, Kirsten Skamstrup, Poulsen, Lars Kærgaard, Lazar, Adina, Aguiar, Rita, Lopes, Anabela, Paes, Maria J., Santos, Amélia S., Pereira-Barbosa, M. A., Eke Gungor, Hatice, Uytun, Salih, Sahiner, Umit Murat, Altuner Torun, Yasemin, Zivanovic, Mirjana, Atanasković-Marković, Marina, Vesel, Tina, Nahtigal, Mihaela, Obermayer-Temlin, Andreja, Križnik, Eva Šoster, Maslar, Mirjana, Bizjak, Ruben, Tomšič-Matic, Marjeta, Posega-Devetak, Sonja, Skerbinjek-Kavalar, Maja, Predalič, Mateja, Avčin, Tadej, Pouessel, Guillaume, Beaudouin, Etienne, Moneret-Vautrin, Anne M., Deschildre, Antoine, Viñas, Marta, Borja, Bartolomé, Hernández, Nora, Castillo, Mª José, Izquierdo, Adriana, Ibero, Marcel, Kocabas, Can Naci, Heming, Camille, Garrett, Emily, Blackstock, Adam, Chodhari, Rahul, Belohlavkova, Simona, Kopelentova, Eliska, Visek, Petr, Setinova, Ivana, Svarcova, Ivana, Sjölander, Sigrid, Nilsson, Nora, Berthold, Malin, Ekoff, Helena, Borres, Magnus, Nilsson, Caroline, González Domínguez, Loreto, Muñoz Archidona, Cristina, Moreira Jorge, Ana, Quevedo Teruel, Sergio, Bracamonte Bermejo, Teresa, Castillo Fernández, Miriam, Pineda de la Losa, Fernando, Echeverría Zudaire, Luis Ángel, Vrani, Olga, Mavroudi, Antigone, Fotoulaki, Maria, Emporiadou, Maria, Spiroglou, Kleomenis, Xinias, Ioannis, Sadreddini, Helyeh A., Warnes, Mia, Traves, Donna, Kostić, Gordana, Filipovic, Đorđe, Sittisomwong, Sawapon, Sittisomwong, Siripong, Podolec, Zygmunt, Hartel, Marcin, Panek, Daria, Podolec-Rubiś, Magdalena, Banasik, Tomasz, Abbasi, Elham, Moghtaderi, Mozhgan, Sanneerappa, Phani, Deliu, Alina, Kutty, Moosa, Ramesh, Nagabathula, Sherkat, Roya, Sabri, Mohammad Reza, Dehghan, Bahar, Bigdelian, Hamid, Raeesi, Nahid, Afshar, Mino, Rahimi, Hamid, Klein, Christoph, Al-Jebouri, Mohemid, Svitich, Oxana A., Zubacheva, Daria O., Potemkin, Dmitrii A., Gankovskaya, Ludmila V., Zverev, Vitalii V., OB Doyle, Elaine, Gallagher, Paul, Dewlett, Sherine, Man, Kin, Pocock, James, Gerrardhughes, Anna, Wasilewska, Jolanta, Kaczmarski, Maciej, Lebensztejn, Dariusz, Thuraisingham, Chandramani, Sinniah, Davendralingam, Chen, Yue, Mei, Xiaomei, Ozdogan, Sebnem, Karadeniz, Pinar, Ayyildiz-Emecen, Durdugul, Oncul, Ummuhan, Sari, Gizem, Cavdar, Sabanur, Farzan, Niloufar, Vijverberg, Susanne J., Palmer, Colin J., Tantisira, Kelan G., Maitland-van der Zee, Anke-Hilse, Yavuzyilmaz, Fatma, Urganci, Nafiye, Usta, Merve, Hoxha, Mehmet, Basho, Maksim, Wandalsen, Gustavo F., Monteiro, Fernanda, Lame, Blerta, Mesonjesi, Eris, Sherri, Arjeta, Ibranji, Alkerta, Gjati, Laert, Loloci, Gjustina, Bardhi, Ardii, Moghtaderi, Behnam, Farjadian, Shirin, Eghtedari, Dorna, Olaya, Manuela, Del Mar Vasquez, Laura, Ramirez, Luis Fernando, Serrano, Carlos Daniel, Usta Guc, Belgin, Asilsoy, Suna, Ozer, Fulya, Shopova, Sylvia, Papochieva, Vera, Loekmanwidjaja, Jessica, Mallozi, Márcia, Ratner, Paul, Soteres, Daniel, Novák, Zoltán, Yáñez, Anahí, Ildikó, Kiss, Kuna, Piotr, Tortajada, Miguel, Feuerhahn, Julia, Blome, Christine, Hadler, Meike, Karagiannis, Efstrathios, Langenbruch, Anna, Augustin, Matthias, Roux, Michel, Kakudo, Shinji, Zeldin, Robert K., Sokolova, Anna, Silva, Tiago Milheiro, Zivanovic, Snezana S., Cvetkovic, Vesna, Nikolic, Ivana, Zivanovic, Sonja J., Saranac, Ljiljana, Nesterenko, Zoia, Radic, Snezana, Milenkovic, Branislava, Smiljanic, Spomenka, Micic-Stanijevic, Milka, Calovic, Olivera, Hofbauer, Anne Marie Bro, Agertoft, Lone, Everson, Lucy, Kearney, Jessica, Coppel, Jonny, Braithwaite, Simon, Christiansen, Elisabeth S., Kjaer, Henrik Fomsgaard, Eller, Esben, Mørtz, Charlotte G., Halken, Susanne, Román India, Cristina, Jiménez Jiménez, Juana, Echeverría Zudaire, Luis, O’Connor, Cathal, Kanti, Varvara, Lünnemann, Lena, Malise, Günther, Ludriksone, Laine, Stroux, Andrea, Henrich, Wolfgang, Abu-Dakn, Michael, Blume-Peytavi, Ulrike, Garcia Bartels, Natalie, Schario, Marianne, Stanley, Thorsten, Brandenbarg, Nicolien, Boardman, Alia, McGreevy, Gary, Rodger, Emily, Knight, Katherine, Taylor, Trisha, Scanlan, Gemma, Christoph, Grüber, van Stuivenberg, Margriet, Mosca, Fabio, Moro, Guido, Chirico, Gaetano, Braegger, Christian P., Riedler, Joseph, Yavuz, Yalcin, Boehm, Günther, Arasi, Stefania, Crisafulli, Giuseppe, Caminiti, Lucia, Porcaro, Federica, Pajno, Giovanni Battista, Tanaka, Akane, Togawa, Yaei, Oida, Kumiko, Kambe, Naotomo, Arkwright, Peter, Amagai, Yosuke, Shimojo, Naoki, Sato, Yasunori, Mochizuki, Hiroyuki, Jang, Hyosun, Ishizaka, Saori, Matsuda, Hiroshi, Barlianto, Wisnu, Olivianto, Ery, Chandra Kusuma, H. M. S., Mollica, Mariapia, Trinchese, Giovanna, Alfano, Elena, Amato, Francesco, Pirozzi, Claudio, Calignano, Antonio, Meli, Rosaria, Rossberg, Siri, Gerhold, Kerstin, Zimmermann, Kurt, Zaino, Mohammad, Geske, Thomas, Hamelmann, Eckard, Bogovic, Sarah, van den Berg, Jochem, Janssen, Chantal, Claver, Angela, Martin-Muñoz, Mª Flor, Martorell, C., Belver, M. T., Alonso Lebrero, E., Zapatero, L., Fuentes, V., Piqué, M., Plaza, A., Muñoz, C., Blasco, Cristina, Villa, B., Gómez, C., Nevot, S., García, J. M., Echeverria, L., DeWitt, Brenda, Holloway, Judith, Hodge, Donald, Ludman, Sian, Jafari-Mamaghani, Merhdad, Ebling, Rosemary, Fox, Adam T., Lack, Gideon, Lovén Björkman, Sofia, Ballardini, Natalia, Basu, Supriyo, Hallet, Jenny, Srinivas, Jyothi, Stringer, Hazel, Jay, Nicola, Fonseca, Paula, Vieira, Clara, Mastrorilli, Carla, Caffarelli, Carlo, Asero, Riccardo, Tripodi, Salvatore, Dondi, Arianna, Ricci, Gianpaolo, Povesi Dascola, Carlotta, Calamelli, Elisabetta, Cipriani, Francesca, Di Rienzo Businco, Andrea, Bianchi, Annamaria, Candelotti, Paolo, Frediani, Tullio, Verga, Carmen, Korovessi, Paraskevi, Tiliakou, Skevi, Tavoulari, Evaggelia, Moraiti, Kalliopi-Maria, Tee, Wan Jean, Deiratany, Samir, Seedhoo, Raymond, McNamara, Roisin, Okafor, Ike, Khaleva, Ekaterina, Novic, Gennady, Bychkova, Natalia, Abd Al-Aziz, Amany, Fatouh, Amany, Motawie, Ayat, Bostany, Eman El, Ibrahim, Amr, Andonova, Sylvia, Savov, Alexey, Zoto, Maria, Kyriakakou, Marialena, Vassilopoulou, Mariza, Balaska, Athina, Kostaridou, Stavroula, Wartna, Jorien, Bohnen, Arthur M., Elshout, Gijs, Pols, David H. J., Bindels, Patrick J. E., Seys, Sven F., Dilissen, Ellen, Van der Eycken, Sarah, Schelpe, An-Sofie, Marijsse, Gudrun, Troosters, Thierry, Vanbelle, Vincent, Aertgeerts, Sven, Ceuppens, Jan L., Dupont, Lieven J., Peers, Koen, Bullens, Dominique M., Lokas, Sandra Bulat, Zivkovic, Jelena, Nogalo, Boro, Kobal, Iva Mrkic, Oliveira, Georgeta, Pike, Katharine, Melo, Alda, Amélia, Tomás, Cidrais Rodrigues, José Carlos, Serrano, Cristina, Lopes dos Santos, José Manuel, Lopes, Carla, Schauer, Uwe, Bergmann, Karl-Christian, Moral, Luis, Toral, Teresa, Marco, Nuria, Avilés, Beléns García, Fuentes, Mª Jesús, Garde, Jesús, Montahud, Cristina, Perona, Javier, Forniés, Mª José, Arroabarren, Esozia, Anda, Marta, Sanz, Maria Luisa, Lizaso, Maria Teresa, Arregui, Candida, May, Sara, Hartz, Martha, Joshi, Avni, Park, Miguel A., Posega Devetak, Sonja, Koren Jeverica, Anja, Castro, Leonor, Gouveia, Carolina, Marques, Ana Carvalho, Cabral, Antonio Jorge, Amaral, Luis, Carolino, Fabrícia, Castro, Eunice, Passos, Madalena, Cernadas, Josefina R., Amaral, Luís, Dias de Castro, Eunice, Pineda, Fernando, Gomes, Armanda, Brough, Helen, Röhmel, Jobst, Schwarz, Carsten, Mehl, Anne, Stock, Philippe, Staab, Doris, Seib, Christine, Critchlow, Anita, Barber, Alyson, Delavalle, Belen, Garriga, Teresa, Vilá, Blanca, Astolfi, Annalisa, Di Chiara, Costanza, Neri, Iria, Patrizi, Annalisa, Neskorodova, Katerina, Kudryavtseva, Asya, Alvarez, Jorge, Palacios, Miriam, Martinez-Merino, Marta, and Vaquero, Ibone
- Abstract
Table of contents WORKSHOP 4: Challenging clinical scenarios (CS01–CS06) CS01 Bullous lesions in two children: solitary mastocytoma S. Tolga Yavuz, Ozan Koc, Ali Gungor, Faysal Gok CS02 Multi-System Allergy (MSA) of cystic fibrosis: our institutional experience Jessica Hawley, Christopher O’Brien, Matthew Thomas, Malcolm Brodlie, Louise Michaelis CS03 Cold urticaria in pediatric age: an invisible cause for severe reactions Inês Mota, Ângela Gaspar, Susana Piedade, Graça Sampaio, José Geraldo Dias, Miguel Paiva, Mário Morais-Almeida CS04 Angioedema with C1 inhibitor deficiency in a girl: a challenge diagnosis Cristina Madureira, Tânia Lopes, Susana Lopes, Filipa Almeida, Alexandra Sequeira, Fernanda Carvalho, José Oliveira CS05 A child with unusual multiple organ allergy disease: what is the primer? Fabienne Gay-Crosier CS06 A case of uncontrolled asthma in a 6-year-old patient Ioana-Valentina Nenciu, Andreia Florina Nita, Alexandru Ulmeanu, Dumitru Oraseanu, Carmen Zapucioiu ORAL ABSTRACT SESSION 1: Food allergy (OP01–OP06) OP01 Food protein-induced enterocolitis syndrome: oral food challenge outcomes for tolerance evaluation in a Pediatric Hospital Adrianna Machinena, Olga Domínguez Sánchez, Montserrat Alvaro Lozano, Rosa Jimenez Feijoo, Jaime Lozano Blasco, Mònica Piquer Gibert, Mª Teresa Giner Muñoz, Marcia Dias da Costa, Ana Maria Plaza Martín OP02 Characteristics of infants with food protein-induced enterocolitis syndrome and allergic proctocolitis Ebru Arik Yilmaz, Özlem Cavkaytar, Betul Buyuktiryaki, Ozge Soyer, Cansin Sackesen OP03 The clinical and immunological outcomes after consumption of baked egg by 1–5 year old egg allergic children: results of a randomised controlled trial MerrynNetting, Adaweyah El-Merhibi, Michael Gold, PatrickQuinn, IrmeliPenttila, Maria Makrides OP04 Oral immunotherapy for treatment of egg allergy using low allergenic, hydrolysed egg Stavroula Giavi, Antonella Muraro, Roger Lauener, Annick Mercenier, Eugen Bersuch, Isabella M. Montagner, Maria Passioti, Nicolò Celegato, Selina Summermatter, Sophie Nutten, Tristan Bourdeau, Yvonne M. Vissers, Nikolaos G. Papadopoulos OP05 Chemical modification of a peanut extract results in an increased safety profile while maintaining efficacy Hanneke van der Kleij, Hans Warmenhoven, Ronald van Ree, Raymond Pieters, Dirk Jan Opstelten, Hans van Schijndel, Joost Smit OP06 Administration of the yellow fever vaccine in egg allergic children Roisin Fitzsimons, Victoria Timms, George Du Toit ORAL ABSTRACT SESSION 2: Asthma (OP07–OP12) OP07 Previous exacerbation is the most important risk factor for future exacerbations in school-age children with asthma S. Tolga Yavuz, Guven Kaya, Mustafa Gulec, Mehmet Saldir, Osman Sener, Faysal Gok OP08 Comparative study of degree of severity and laboratory changes between asthmatic children using different acupuncture modalities Nagwa Hassan, Hala Shaaban, Hazem El-Hariri, Ahmed Kamel Inas E. Mahfouz OP09 The concentration of exhaled carbon monoxide in asthmatic children with different controlled stadium Papp Gabor, Biro Gabor, Kovacs Csaba OP10 Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: a randomised clinical trial Bo Chawes, Klaus Bønnelykke, Jakob Stokholm, Lene Heickendorff, Susanne Brix, Morten Rasmussen, Hans Bisgaard OP11 Lung function development in childhood Henrik Wegener Hallas, Bo Chawes, Lambang Arianto, Hans Bisgaard OP12 Is the effect of maternal and paternal asthma different in female and male children before puberty? Maike Pincus, Thomas Keil, Andreas Reich, Ulrich Wahn, Susanne Lau, Linus Grabenhenrich ORAL ABSTRACT SESSION 3: Epidemiology—genetics (OP13–OP18) OP13 Lifestyle is associated with incidence and category of allergen sensitisation: the ALADDIN birth cohort Sara Fagerstedt, Helena Marell Hesla, Emelie Johansson, Helen Rosenlund, Axel Mie, Annika Scheynius, Johan Alm OP15 Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance Jorge Esparza-Gordillo, Anja Matanovic, Ingo Marenholz, Anja Bauerfeind, Klaus Rohde, Katja Nemat, Min-Ae Lee-Kirsch, Magnus Nordenskjöld, Marten C. G. Winge, Thomas Keil, Renate Krüger, Susanne Lau, Kirsten Beyer, Birgit Kalb, Bodo Niggemann, Norbert Hübner, Heather J. Cordell, Maria Bradley, Young-Ae Lee OP16 Allergic multimorbidity of asthma, rhinitis and eczema in the first 2 decades of the German MAS birth cohort Thomas Keil, Hannah Gough, Linus Grabenhenrich, Dirk Schramm, Andreas Reich, John Beschorner, Antje Schuster, Carl-Peter Bauer, Johannes Forster, Fred Zepp, Young-Ae Lee, Renate Bergmann, Karl Bergmann, Ulrich Wahn, Susanne Lau OP17 Childhood anaphylaxis: a growing concern Filipe Benito Garcia, Inês Mota, Susana Piedade, Ângela Gaspar, Natacha Santos, Helena Pité, Mário Morais-Almeida OP18 Indoor exposure to molds and dampness in infancy and its association to persistent atopic dermatitis in school age. Results from the Greek ISAAC II study Athina Papadopoulou, Despina Mermiri, Elpida Xatziagorou, Ioannis Tsanakas, Stavroula Lampidi, Kostas Priftis ORAL ABSTRACT SESSION 4: Pediatric rhinitis—immunotherapy (OP19–OP24) OP19 Associations between residential greenness and childhood allergic rhinitis and aeroallergen sensitisation in seven birth cohorts Elaine Fuertes, Iana Markevych, Gayan Bowatte, Olena Gruzieva, Ulrike Gehring, Allan Becker, Dietrich Berdel, Michael Brauer, Chris Carlsten, Barbara Hoffmann, Anita Kozyrskyj, Caroline Lodge, Göran Pershagen, Alet Wijga, Heinrich Joachim OP20 Full symptom control in pediatric patients with allergic rhinitis and asthma: results of a 2-year sublingual allergen immunotherapy study Zorica Zivkovic, Ivana Djuric-Filipovic, Jasmina Jocić-Stevanovic, Snežana Zivanovic OP21 Nasal epithelium of different ages of atopic subjects present increased levels of oxidative stress and increased cell cytotoxicity upon rhinovirus infection Styliani Taka, Dimitra Kokkinou, Aliki Papakonstantinou, Panagiota Stefanopoulou, Anastasia Georgountzou, Paraskevi Maggina, Sofia Stamataki, Vassiliki Papaevanggelou, Evangelos Andreakos, Nikolaos G. Papadopoulos OP22 Cluster subcutaneous immunotherapy schedule: tolerability profile in children Monica Piquer Gibert, Montserrat Alvaro Lozano, Jaime Lozano Blasco, Olga Domínguez Sánchez, Rosa Jiménez Feijoo, Marcia Dias da Costa, Mª Teresa Giner Muñoz, Adriana Machinena Spera, Ana Maria Plaza Martín OP23 Rhinitis as a risk factor for asthma severity in 11-year old children: population-based cohort study Matea Deliu, Danielle Belgrave, Angela Simpson, Adnan Custovic OP24 The Global Lung Function Initiative equations in airway obstruction evaluation of asthmatic children João Gaspar Marques, Pedro Carreiro-Martins, Joana Belo, Sara Serranho, Isabel Peralta, Nuno Neuparth, Paula Leiria-Pinto POSTER DISCUSSION SESSION 1: Food allergy (PD01–PD05) PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactions Marta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel Juan PD02 FoxP3 epigenetic features in children with cow milk allergy Lorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni Canani PD04 Combined milk and egg allergy in early childhood: let them eat cake? Santanu Maity, Giuseppina Rotiroti, Minal Gandhi PD05 Introduction of complementary foods in relation to allergy and gut microbiota in farm and non-farm children Karin Jonsson, Annika Ljung, Bill Hesselmar, Ingegerd Adlerbert, Hilde Brekke, Susanne Johansen, Agnes Wold, Ann-Sofie Sandberg POSTER DISCUSSION SESSION 2: Asthma and wheeze (PD06–PD16) PD06 The association between asthma and exhaled nitric oxide is influenced by genetics and sensitisation Björn Nordlund, Cecilia Lundholm, Villhelmina Ullemar, Marianne van Hage, Anne Örtqvist, Catarina Almqvist PD09 Prevalence patterns of infant wheeze across Europe Anna Selby, Kate Grimshaw, Thomas Keil, Linus Grabenhenrich, Michael Clausen, Ruta Dubakiene, Alessandro Fiocchi, Marek Kowalski, Nikos Papadopoulos, Marta Reche, Sigurveig Sigurdardottir, Aline Sprikkleman, Paraskevi Xepapadaki, Clare Mills, Kirsten Beyer, Graham Roberts PD10 Epidemiologic changes in recurrent wheezing infants Herberto Jose Chong Neto, Gustavo Falbo Wandalsen, Ana Carolina Dela Bianca, Carolina Aranda, Nelson Augusto Rosário, Dirceu Solé, Javier Mallol, Luis García Marcos PD13 A single nucleotide polymorphism in the GLCCI1 gene is associated with response to asthma treatment in children IvanaBanic, Matija Rijavec, Davor Plavec, Peter Korosec, Mirjana Turkalj PD14 Pollen induced asthma: Could small molecules in pollen exacerbate the protein-mediated allergic response? Alen Bozicevic, Maria De Mieri, Matthias Hamburger PD15 A qualitative study to understand how we can empower teenagers to better self-manage their asthma Simone Holley, Ruth Morris, Frances Mitchell, Rebecca Knibb, Susan Latter, Christina Liossi, Graham Roberts PD16 Polymorphism of endothelial nitric oxide synthase (eNOS) gene among Egyptian children with bronchial asthma Mostafa M. M. Hassan POSTER DISCUSSION SESSION 3: Mechanisms—Epidemiology (PD17–PD21) PD17 Pregnancy outcomes in relation to development of allergy in a Swedish birth cohort Malin Barman, Anna Sandin, Agnes Wold, Ann-Sofie Sandberg PD18 Evolution of the IgE response to house dust mite molecules in childhood Daniela Posa, Serena Perna, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Antje Schuster, Ulrich Wahn, Thomas Keil, Susanne Lau, Kuan-Wei Chen, Yvonne Resch, Susanne Vrtala, Rudolf Valenta, Paolo Maria Matricardi PD19 Antibody recognition of nsLTP-molecules as antigens but not as allergens in the German-MAS birth cohort Olympia Tsilochristou, Alexander Rohrbach, Antonio Cappella, Stephanie Hofmaier, Laura Hatzler, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Antje Schuster, RaffaeleD’Amelio, Ulrich Wahn, Thomas Keil, Susanne Lau, Paolo Maria Matricardi PD20 Early life colonization with Lactobacilli and Staphylococcus aureus oppositely associates with the maturation and activation of FOXP3+ CD4 T-cells Sophia Björkander, Maria A. Johansson, Gintare Lasaviciute, Eva Sverremark-Ekström PD21 Genome-wide meta-analysis identifies 7 susceptibility loci involved in the atopic march Ingo Marenholz, Jorge Esparza-Gordillo, Franz Rüschendorf, Anja Bauerfeind, David P. Strachan, Ben D. Spycher, Hansjörg Baurecht, Patricia Margaritte-Jeannin, Annika Sääf, Marjan Kerkhof, Markus Ege, Svetlana Baltic, Melanie C Matheson, Jin Li, Sven Michel, Wei Q. Ang, Wendy McArdle, Andreas Arnold, Georg Homuth, Florence Demenais, Emmanuelle Bouzigon, Cilla Söderhäll, Göran Pershagen, Johan C. de Jongste, Dirkje S Postma, Charlotte Braun-Fahrländer, Elisabeth Horak, Ludmila M. Ogorodova, Valery P. Puzyrev, Elena Yu Bragina, Thomas J Hudson, Charles Morin, David L Duffy, Guy B Marks, Colin F Robertson, Grant W Montgomery, Bill Musk, Philip J Thompson, Nicholas G. Martin, Alan James, Patrick Sleiman, Elina Toskala, Elke Rodriguez, Regina Fölster-Holst, Andre Franke, Wolfgang Lieb, Christian Gieger, Andrea Heinzmann, Ernst Rietschel, Thomas Keil, Sven Cichon, Markus M Nöthen, Craig E Pennell, Peter D Sly, Carsten O Schmidt, Anja Matanovic, Valentin Schneider, Matthias Heinig, Norbert Hübner, Patrick G. Holt, Susanne Lau, Michael Kabesch, Stefan Weidinger, Hakon Hakonarson, Manuel AR Ferreira, Catherine Laprise, Maxim B. Freidin, Jon Genuneit, Gerard H Koppelman, Erik Melén, Marie-Hélène Dizier, A. John Henderson, Young Ae Lee POSTER DISCUSSION SESSION 4: Food allergy—Anaphylaxis (PD22–PD26) PD22 Atopy patch test in food protein induced enterocolitis caused by solid food Purificacion González-Delgado, Esther Caparrós, Fernando Clemente, Begoña Cueva, Victoria M. Moreno, Jose Luis Carretero, Javier Fernández PD23 Watermelon allergy: a novel presentation Kate Swan, George Du Toit PD24 A pilot study evaluating the usefulness of a guideline template for managing milk allergy in primary care Mudiyur Gopi, Tim Smith, Edara Ramesh, Arun Sadasivam PD26 Efficacy and safety of cow’s milk oral immunotherapy protocol Inês Mota, Filipe Benito Garcia, Susana Piedade, Angela Gaspar, Graça Sampaio, Cristina Arêde, Luís Miguel Borrego, Graça Pires, Cristina Santa-Marta, Mário Morais-Almeida POSTER DISCUSSION SESSION 5: Prevention and treatment—Allergy (PD27–PD36) PD27 Allergy-protection by the lactic acid bacterium Lactococcus lactis G121: mode-of-action as revealed in a murine model of experimental allergy Stephanie Brand, Karina Stein, Holger Heine, Marion Kauth PD29 The relationship between quality of life and morning salivary cortisol after acute bronchiolitis in infancy Leif Bjarte Rolfsjord, Egil Bakkeheim, Johan Alm, Håvard Ove Skjerven, Kai-Håkon Carlsen, Jon Olav Hunderi, Teresa Løvold Berents, Petter Mowinckel, Karin C. Lødrup Carlsen PD30 Randomised trial of the efficacy of MP29-02* compared with fluticasone propionate nasal spray in children aged ≥6 years to <12 years with allergic rhinitis Ulrich Wahn, Ullrich Munzel, William Berger PD31 10 mg of oral bilastine in 2 to 11 years old children has similar exposure to the adult therapeutic dose (20 mg) Ulrich Wahn, Román Valiente, Valvanera Vozmediano, John C. Lukas, Mónica Rodríguez PD33 Daily symptoms, nocturnal symptoms, activity limitations and reliever therapies during the three steps of IOEASMA programme: a comparison Sebastiano Guarnaccia, Luigi Vitale, Ada Pluda, Emanuele D’Agata, Denise Colombo, Stefano Felici, Valeria Gretter, Susanna Facchetti, Gaia Pecorelli, Cristina Quecchia PD34 Sensitisation to an inert aeroallergen in weaning rats and longstanding disease, in a sensitisation-tolerant and easily tolerisable rodent strain George Guibas, Evangelia Spandou, Spyridon Megremis, Peter West, Nikolaos Papadopoulos PD35 Bacterial and fungi exposure in school and allergic sensitisation in children João Cavaleiro Rufo, Joana Madureira, Inês Paciência, Lívia Aguiar, Patrícia Padrão, Mariana Pinto, Luís Delgado, Pedro Moreira, João Paulo Teixeira, Eduardo Oliveira Fernandes, André Moreira PD36 Comparative study of allergy rhinitis between two populations: children vs. adults Adriana Izquierdo Dominguez, Antonio Valero, Joaquim Mullol, Alfonso Del Cuvillo, Javier Montoro, Ignacio Jauregui, Joan Bartra, Ignacio Davila, Marta Ferrer, Joaquin Sastre POSTER VIEWING SESSION 1: Inflammation—Genetics—Immunology—Dermatology (PP01–PP09) PP01 Immune profile in late pregnancy: immunological markers in atopic asthmaticwomen as risk factors for atopy in the progeny Catarina Martins, Jorge Lima, Maria José Leandro, Glória Nunes, Jorge Cunha Branco, Hélder Trindade, Luis Miguel Borrego PP02 The impact of neonatal sepsis on development of allergic diseases Secil Conkar, Mehtap Kilic, Canan Aygun, Recep Sancak PP03 Clinical overview of selective IgE deficiency in childhood Athina Papadopoulou, Eleni Tagalaki, Lambros Banos, Anna Vlachou, Fotini Giannoula, Despina Mermiri PP04 Inverse relationship between serum 25(ΟΗ) vitamin D3 and total IgE in children and adolescence Athina Papadopoulou, Stavroula Lampidi, Marina Pavlakou, Maria Kryoni, Kostas Makris PP05 PP06 PP07 Asthma control questionnaire and specific IgE in children Snezhina Lazova, Guergana Petrova, Dimitrinka Miteva, Penka Perenovska PP08 Features of chronic urticaria of adolescents Aliya Klyucharova, Olesya Skorohodkina PP09 Cutaneous mastocytosis in children: a clinical analysis of 8 cases in Greece Dimitra Koumaki, Alkisti Manousaki, Maria Agrapidi, Lida Iatridou, Omima Eruk, Konstantinos Myridakis, Emmanouil Manousakis, Vasiliki Koumaki POSTER VIEWING SESSION 2: Food allergy—Anaphylaxis (PP10–PP47) PP10 Prognostic factors in egg allergy Maria Dimou, Maria Ingemansson, Gunilla Hedlin PP11 Evaluation of the efficacy of an amino acid-based formula in infants who are intolerant to extensively hydrolysed protein formula Nitida Pastor, Delphine de Boissieu, Jon Vanderhoof, Nancy Moore, Kaitlin Maditz PP12 Anaphylaxis and epinephrine auto-injector use: a survey of pediatric trainees Adeli Mehdi, Shaza Elhassan, Carolin Beck, Ahmed Al-Hammadi PP13 Anaphylaxis in children: acute management in the Emergency Department Ioana Maris, Ronan O’Sullivan, Jonathan Hourihane, PP14 Understanding Cumbrian schools preparedness in managing children at risk of anaphylaxis in order to provide training and support which will create healthy and safe environments for children with allergies George Raptis, Louise Michaelis PP15 A new valid and reliable parent and child questionnaire to measure the impact of food protein enterocolitis syndrome on children: the FPIES Quality of Life Questionnaire (FPIESQL), Parent and Child Short Form Audrey DunnGalvin, Matthew Greenhawt, Carina Venter, Jonathan Hourihane PP16 An in-depth case study investigation of the experiences of teenagers and young adults in growing up and living with food allergy with emphasis on coping, management and risk, support, and social and self-identity Evelyn O’Regan, Duncan Cronin, Jonathan Hourihane, Anna O’Reilly, Audrey DunnGalvin PP17 Cow’s milk protein allergy in Constantine. A retrospective study of 62 cases between 1996 and 2013 Foued Abdelaziz, Dounia Khelifi-Touhami, Nihad Selim, Tahar Khelifi-Touhami PP18 PP19 Cow’s milk and egg oral immunotherapy in children older than 5 years Pablo Merida, Ana Mª Plaza, Juan Heber Castellanos, Adrianna Machinena, Montserrat Alvaro Lozano, Jaime Lozano, Olga Dominguez, Monica Piquer, Rosa Jimenez, Mª Teresa Giner PP20 Professionals’ awareness of management of Cow’s Milk Protein Allergy (CMPA) in North Wales Hospitals Konstantinos Kakleas, Manohar Joishy, Wendmu Maskele, Huw R. Jenkins PP21 PP22 Anaphylaxis: the great unknown for teachers. Presentation of a protocol for schools Mercedes Escarrer, Agustín Madroñero, Maria Teresa Guerra, Juan Carlos Julia, Juan Carlos Cerda, Javier Contreras, Eulalia Tauler, Maria Jesus Vidorreta, Ana Rojo, Silvia Del Valle PP23 Challenges facing children with food allergies and their parents in out of school activity sectors Niamh Flynn PP24 A review of food challenges at a Regional Irish Centre Gary Foley, Carol Harmon, John Fitzsimons PP25 The use of epinephrine in infants with anaphylaxis Krasimira Baynova, Ávila Maria Del Robledo, Labella Marina PP26 PP27 PP28 Mother’s psychological state predicts the expression of symptoms in food allergic children Aaron Cortes, Alicia Sciaraffia, Angela Castillo PP29 The correlation between sIgE towards tree nuts and birch pollen in a Danish Pediatric Allergy Clinic Nanna Juel-Berg, Kirsten Skamstrup Hansen, Lars Kærgaard Poulsen PP30 Food allergy in children: evaluation of parents’ use of online social media Andreia Florina Nita, Ioana Valentina Nenciu, Adina Lazar, Dumitru Oraseanu PP31 The impact of food allergy on quality of life: FAQLQ questionnaire Rita Aguiar, Anabela Lopes, Maria J. Paes, Amélia S. Santos, M. A. Pereira-Barbosa PP32 An unexpected cause of anaphylaxis: potato Hatice Eke Gungor, Salih Uytun, Umit Murat Sahiner, Yasemin Altuner Torun PP33 Is it clinical phenotype of allergic diseases determined by sensitisation to food? Mirjana Zivanovic, Marina Atanasković-Marković PP34 PP35 Prescribing adrenaline auto-injectors in children in 2014: the data from regional pediatricians Tina Vesel, Mihaela Nahtigal, Andreja Obermayer-Temlin, Eva Šoster Križnik, Mirjana Maslar, Ruben Bizjak, Marjeta Tomšič-Matic, Sonja Posega-Devetak, Maja Skerbinjek-Kavalar, Mateja Predalič, Tadej Avčin PP36 Who should have an adrenaline autoinjector? Adherence to the European and French guidelines among 121 allergists from the Allergy Vigilance Network Guillaume Pouessel, Etienne Beaudouin, Anne M. Moneret-Vautrin, Antoine Deschildre, Allergy Vigilance Network PP37 Anaphylaxis by Anacardium Occidentale Marta Viñas, Bartolomé Borja, Nora Hernández, Mª José Castillo, Adriana Izquierdo, Marcel Ibero PP38 Anaphylaxis with honey in a child S. Tolga Yavuz, Ali Gungor, Betul Buyuktiryaki, Ozan Koc, Can Naci Kocabas, Faysal Gok PP39 Evaluation of courses adopted to children on prevention, recognition and management of anaphylaxis Tina Vesel, Mihaela Nahtigal PP40 Symptomatic dust mites and shrimp allergy: three pediatric case reports Filipa Almeida, Susana Lopes, Cristina Madureira, Tânia Lopes, Fernanda Carvalho PP41 Poor identification rates of nuts by high risk individuals: a call for improved education and support for families Camille Heming, Emily Garrett, Adam Blackstock, Santanu Maity, Rahul Chodhari PP42 DAFALL: database of food allergies in the Czech Republic Simona Belohlavkova, Eliska Kopelentova, Petr Visek, Ivana Setinova, Ivana Svarcova PP43 Serological cross-reactivity between grass and wheat is not only caused by profilins and CCDs Sigrid Sjölander, Nora Nilsson, Malin Berthold, Helena Ekoff, Gunilla Hedlin, Magnus Borres, Caroline Nilsson PP44 Oil body associated proteins in children with nuts allergy. Allergens to consider in IgE-mediated nuts allergy Loreto González Domínguez, Cristina Muñoz Archidona, Ana Moreira Jorge, Sergio Quevedo Teruel, Teresa Bracamonte Bermejo, Miriam Castillo Fernández, Fernando Pineda de la Losa, Luis Ángel Echeverría Zudaire PP45 PP46 Protective effect of helicobacter pylori infection against food allergy in children Olga Vrani, Antigone Mavroudi, Maria Fotoulaki, Maria Emporiadou, Kleomenis Spiroglou, Ioannis Xinias PP47 Anaphylaxis pathway: A road tryp-tase to success? Helyeh A. Sadreddini, Mia Warnes, Donna Traves POSTER VIEWING SESSION 3: Miscellaneous (PP48–PP58) PP48 Surveillance study on safety of SLIT in pediatric population Ivana Djuric-Filipovic, Zorica Zivkovic, Snežana Zivanovic, Gordana Kostić, Đorđe Filipovic PP49 Efficacy and safety of mixed mite subcutaneous immunotherapy among allergic rhinitis patients in the Northeastern Thailand Sawapon Sittisomwong, Siripong Sittisomwong PP50 Effect of inhaled beclomethasone or placebo on brain stem activity in a patient chronically treated with steroids: preliminary report Zygmunt Podolec, Marcin Hartel, Daria Panek, Magdalena Podolec-Rubiś, Tomasz Banasik PP51 Sensitisation to aeroallergens in patients with allergic rhinitis, asthma and atopic dermatitis in Shiraz, Southwestern Iran Elham Abbasi, Mozhgan Moghtaderi PP52 Referring a child for allergy test: how appropriate are we? Phani Sanneerappa, Alina Deliu, Moosa Kutty, Nagabathula Ramesh PP53 EBV lymphoproliferative disease and cardiac lymphoma in a STK4 deficient patient Roya Sherkat, Mohammad Reza Sabri, Bahar Dehghan, Hamid Bigdelian, Nahid Raeesi, Mino Afshar, Hamid Rahimi, Christoph Klein PP54 A case study: the effect of massive honeybees attack on various body parameters atopic girl including allergy Mohemid Al-Jebouri PP55 The role of TLR9, NLRP3 and proIL-1β in activation of antiviral innate immunity Oxana A. Svitich, Daria O. Zubacheva, Dmitrii A. Potemkin, Ludmila V. Gankovskaya, Vitalii V. Zverev PP56 Overnight pulse oximetry, as a screening tool to diagnose obstructive sleep apnoea. How effective is it? Phani Sanneerappa, Elaine OB Doyle, Paul Gallagher, Nagabathula Ramesh PP57 The presentation and management of acute urticaria and allergic reactions in children in a multi-ethnic, inner city Emergency Department (ED) Sherine Dewlett, Kin Man, Minal Gandhi, James Pocock, Anna Gerrardhughes PP58 Food allergens responsible for delayed-type sensitisation in atopy patch test in children diagnosed with autism spectrum disorder Jolanta Wasilewska, Maciej Kaczmarski, Dariusz Lebensztejn POSTER VIEWING SESSION 4: Asthma—Rhinitis (PP59–PP87) PP59 Systematic review of incense as a trigger factor for asthma Chandramani Thuraisingham, Davendralingam Sinniah PP60 Increased risks of mood and anxiety disorders in children with asthma Yue Chen, Xiaomei Mei PP61 PP62 Asthma Control Test (ACT) and Pediatric Asthma Quality of Life Questionnaire (PAQLQ) association in children Sebnem Ozdogan, Pinar Karadeniz, Durdugul Ayyildiz-Emecen, Ummuhan Oncul PP63 Seasonal and gender variations in vitamin D levels in children with asthma and its association with pulmonary function tests Sebnem Ozdogan, Gizem Sari, Sabanur Cavdar PP64 Defining treatment response in childhood asthma: rationale and design of the Pharmacogenomics in the Childhood Asthma (PiCA) consortium Niloufar Farzan, Susanne J. Vijverberg, Colin J. Palmer, Kelan G. Tantisira, Anke-Hilseon Maitland-van der Zee behalf of the PiCA consortium PP65 Prevalence of asthma and allergic disease in patients with inflammatory disease compared to celiac disease Fatma Yavuzyilmaz, Sebnem Ozdogan, Nafiye Urganci, Merve Usta PP66 A severe case with cystic fibrosis (CF) asthma Mehmet Hoxha, Maksim Basho PP67 Severe asthma exacerbation complicated with pneumothorax in a child with uncontrolled asthma due to poor treatment compliance Ioana Valentina Nenciu, Andreia Florina Nita, Adina Lazar, Alexandru Ulmeanu, Carmen Zapucioiu, Dumitru Oraseanu PP68 Evaluation of the Pediatric Quality of Life inventory (PedsQL) asthma module among low income asthmatic children and adolescents in Sao Paolo, Brazil Gustavo F. Wandalsen, Fernanda Monteiro, Dirceu Solé PP69 Early initiation of specific immunotherapy in asthma patients leads to higher benefits Blerta Lame, Eris Mesonjesi, Arjeta Sherri PP70 Treatment resistant asthma and rhinosinusitis with recurrent pulmonary infections. Is it primary ciliary dyskinesia? Alkerta Ibranji, Laert Gjati, Gjustina Loloci, Ardii Bardhi PP71 The comparison of sensitisation to animal allergens in children- and adult- onset patients with asthma Behnam Moghtaderi, Shirin Farjadian, Dorna Eghtedari PP72 Characterisation of children less than five years with wheezing episodes in Cali, Colombia Manuela Olaya, Laura Del Mar Vasquez, Luis Fernando Ramirez, Carlos Daniel Serrano PP73 Evaluation of the patients with recurrent croup Belgin Usta Guc, Suna Asilsoy, Fulya Ozer PP74 Obesity in adolescence compromising the asthma control Guergana Petrova, Sylvia Shopova, Vera Papochieva, Snezhina Lazova, Dimitrinka Miteva, Penka Perenovska PP75 Sleep behavior in children with persistent allergic rhinitis Gustavo F. Wandalsen, Jessica Loekmanwidjaja, Márcia Mallozi, Dirceu Solé PP76 Randomised trial of the safety of MP29-02* compared with fluticasone propionate nasal spray in children aged ≥4 years to <12 years with allergic rhinitis William Berger, Ulrich Wahn, Paul Ratner, Daniel Soteres PP77 Safety and tolerability evaluation of bilastine 10 mg in children from 2 to 11 years of age with allergic rhinoconjunctivitis or urticaria Zoltán Novák, Anahí Yáñez, Kiss Ildikó, Piotr Kuna, Miguel Tortajada, Román Valiente, the Bilastine Pediatric Safety Study Group PP78 Sensitisation to Alternaria alternata: Is it a risk factor for severe rhinitis? Susana Lopes, Filipa Almeida, Tânia Lopes, Cristina Madureira, José Oliveira, Fernanda Carvalho PP79 Validation of the Patient Benefit Index (PBI) for the assessment of patient-related outcomes in allergic rhinitis in children Julia Feuerhahn, Christine Blome, Meike Hadler, Efstrathios Karagiannis, Anna Langenbruch, Matthias Augustin PP80 Efficacy of sublingual tablet of house dust mite allergen extracts in adolescents with house dust mite-associated allergic rhinitis Michel Roux, Shinji Kakudo, Efstrathios Karagiannis, Robert K. Zeldin PP81 Lung function improvement in a child treated with omalizumab for bronchial asthma Anna Sokolova, Tiago Milheiro Silva PP82 How to treat a child suffering from asthma, allergic rhinitis, allergy to peanuts and diabetes at the same time? Snezana S. Zivanovic, Vesna Cvetkovic, Ivana Nikolic, Sonja J. Zivanovic PP83 Nitric oxide in exhaled air in the relationship of the degree of sensitisation to aeroallergens Snezana S. Zivanovic, Ljiljana Saranac, Ivana Nikolic, Sonja J. Zivanovic, Zorica Zivkovic PP84 Clinical basis of diagnostic errors in pediatric asthma Zoia Nesterenko PP85 PP86 Childhood asthma control in Serbia and organised Asthma Educational Intervention (AEI) Snezana Radic, Branislava Milenkovic, Spomenka Smiljanic, Milka Micic-Stanijevic, Olivera Calovic PP87 Experience from a group of adolescents with severe allergic asthma treated with Omalizumab Anne Marie Bro Hofbauer, Lone Agertoft THEMATIC POSTER SESSION 1: Prevention and Treatment—Epidemiology (TP01–TP18) TP01 A cost effective primary school asthma education program: pilot study from inner London schools Lucy Everson, Jessica Kearney, Jonny Coppel, Simon Braithwaite, Rahul Chodhari TP02 The prevalence of allergic diseases among 14–15 years old adolescents in two Danish birth cohorts 14 years apart Elisabeth S. Christiansen, Henrik Fomsgaard Kjaer, Esben Eller, Charlotte G. Mørtz, Susanne Halken TP03 Does pattern of sensitisation to phleum pratense change with age? Is it different in children with allergic rhinitis or asthma? Cristina Román India, Ana Moreira Jorge, Loreto González Domínguez, Cristina Muñoz Archidona, Sergio Quevedo Teruel, Teresa Bracamonte Bermejo, Juana Jiménez Jiménez, Luis Echeverría Zudaire TP04 Practicalities of prevention of peanut allergy: modelling a national response to LEAP Cathal O’Connor, Jonathan Hourihane TP05 Comparison of the influence of sunflower seed oil and skin care lotion on the skin barrier function of newborns: a randomised controlled trial Varvara Kanti, Lena Lünnemann, Günther Malise, Laine Ludriksone, Andrea Stroux, Wolfgang Henrich, Michael Abu-Dakn, Ulrike Blume-Peytavi, Natalie Garcia Bartels TP06 The effect of daily skin care on skin barrier properties in infants with dry skin and risk for atopic dermatitis Varvara Kanti, Lena Lünnemann, Laine Ludriksone, Marianne Schario, Andrea Stroux, Ulrike Blume-Peytavi, Natalie Garcia Bartels TP07 Change in sum total aeroallergen skin prick test wheal diameters at 6 months predicts which children will respond to subcutaneous immunotherapy by three years Thorsten Stanley, Nicolien Brandenbarg TP08 Are mobile apps regarding adrenaline auto-injectors accessed by adolescents for support and education in the community? Alia Boardman, Gary McGreevy, Emily Rodger, Katherine Knight, Victoria Timms, Trisha Taylor, Gemma Scanlan, Roisin Fitzsimons TP09 TP10 Prevention of early atopic dermatitis among low-atopy-risk infants by immunoactive prebiotics is not sustained after the first year of life Grüber Christoph, Ulrich Wahn, Margriet van Stuivenberg, Fabio Mosca, Guido Moro, Gaetano Chirico, Christian P. Braegger, Joseph Riedler, Yalcin Yavuz, Günther Boehm TP11 TP12 TP13 Treatment with Omalizumab in a 16-year-old Caucasian girl with refractory solar urticaria Stefania Arasi, Giuseppe Crisafulli, Lucia Caminiti, Federica Porcaro, Giovanni Battista Pajno TP14 Ultra-pure soft water ameliorates skin conditions of adult and child patients with atopic dermatitis Akane Tanaka, Yaei Togawa, Kumiko Oida, Naotomo Kambe, Peter Arkwright, Yosuke Amagai, Naoki Shimojo, Yasunori Sato, Hiroyuki Mochizuki, Hyosun Jang, Saori Ishizaka, Hiroshi Matsuda TP15 Potential adjuvant effect of immunomodulator to improve specific immunotherapy in asthmatic child Wisnu Barlianto, Ery Olivianto, H. M. S. Chandra Kusuma TP16 How can Component Resolved Diagnosis (CRD) influence in Specific Immunotherapy (SIT) prescription, in a Spanish children population Ana Moreira Jorge, Cristina Román India, Loreto González Domínguez, Cristina Muñoz Archidona, Juana Jiménez Jiménez, Teresa Bracamonte Bermejo, Sergio Quevedo Teruel, Luis Echeverría Zudaire TP17 Mitochondrial dysfunction in food allergy: effects of L. rhamnosus GG in a mice model of peanut allergy Rosita Aitoro, Mariapia Mollica, Roberto Berni Canani, Giovanna Trinchese, Elena Alfano, Antonio Amoroso, Lorella Paparo, Francesco Amato, Claudio Pirozzi, Antonio Calignano, Rosaria Meli TP18 Prediction of atopic diseases in childhood: elevated blood eosinophils in infancy in a high risk birth cohort Siri Rossberg, Kerstin Gerhold, Kurt Zimmermann, Mohammad Zaino, Thomas Geske, Eckard Hamelmann, Susanne Lau THEMATIC POSTER SESSION 2: Food allergy—Anaphylaxis (TP19–TP38) TP19 TP20 TP21 Double-blind provocation tests in non-IgE mediated cow’s milk allergy and the occurrence of placebo reactions Sarah Bogovic, Jochem van den Berg, Chantal Janssen TP22 Gradual introduction of baked egg (BE) in egg allergic patients under 2 years old Angela Claver TP23 Randomised controlled trial of SOTI with raw hen’s egg in children with persistent egg allergy I: safety and efficacy of daily vs. weekly protocols of induction Mª Flor Martin-Muñoz, C. Martorell, M. T. Belver, E. Alonso Lebrero, L. Zapatero, V. Fuentes, M. Piqué, A. Plaza, C. Muñoz, A. Martorell, Cristina Blasco, B. Villa, C. Gómez, S. Nevot, J. M. García, L. Echeverria TP24 Randomised controlled trial of SOTI with raw hen’s egg in children with persistent egg allergy II: a randomised controlled trial to study a safer, more effective and easy to perform maintenance (daily vs. every two days) pattern of egg SOTI Mª Flor Martin-Muñoz, C. Martorell, M. T. Belver, E. Alonso Lebrero, L. Zapatero, V. Fuentes, M. Piqué, A. Plaza, C. Muñoz, A. Martorell, Cristina Blasco, B. Villa, C. Gómez, S. Nevot, J. M. García, L. Echeverria TP25 Determining the safety of baked egg home reintroduction for children with mild egg allergy Brenda DeWitt, Judith Holloway, Donald Hodge TP26 Demographics, investigations and patterns of sensitisation in children with oral allergy syndrome in a London Teaching Hospital Sian Ludman, Merhdad Jafari-Mamaghani, Rosemary Ebling, Adam T. Fox, Gideon Lack, George Du Toit TP27 Airborne peanut challenge in children: allergic reactions are rare Sofia Lovén Björkman, Caroline Nilsson, Natalia Ballardini TP28 The nutty question on Pediatric Wards: to be or “nut” to be? Supriyo Basu, Jenny Hallet, Jyothi Srinivas TP29 TP30 TP31 Allergy education in nursery schools Hazel Stringer, Nicola Jay TP32 Food allergy in the first year of life Tânia Lopes, Cristina Madureira, Filipa Almeida, Susana Lopes, Paula Fonseca, Clara Vieira, Fernanda Carvalho TP33 Prevalence and geographic distribution of oral allergy syndrome in Italian children: a multicenter study Carla Mastrorilli, Carlo Caffarelli, Riccardo Asero, Salvatore Tripodi, Arianna Dondi, Gianpaolo Ricci, Carlotta Povesi Dascola, Elisabetta Calamelli, Francesca Cipriani, Andrea Di Rienzo Businco, Annamaria Bianchi, Paolo Candelotti, Tullio Frediani, Carmen Verga, Paolo Maria Matricardi TP34 Are common standardised allergen extracts used in skin test enough in the diagnosis of nuts allergy? Cristina Muñoz Archidona, Loreto González Domínguez, Ana Moreira Jorge, Sergio Quevedo Teruel, Teresa Bracamonte Bermejo, Miriam Castillo Fernández, Fernando Pineda de la Losa, Luis Ángel Echeverría Zudaire TP35 Evaluation of IgE sensitisation in children with allergic proctocolitis and its relationship to atopic dermatitis Despina Mermiri, Paraskevi Korovessi, Skevi Tiliakou, Evaggelia Tavoulari, Kalliopi-Maria Moraiti, Fotini Giannoula, Athina Papadopoulou TP36 Food allergy in children: are we managing them appropriately in the Emergency Department? Wan Jean Tee, Samir Deiratany, Raymond Seedhoo, Roisin McNamara, Ike Okafor TP37 Importance of oil body associated allergenic proteins in nuts suspected allergy children Loreto González Domínguez, Ana Moreira Jorge, Cristina Muñoz Archidona, Teresa Bracamonte Bermejo, Sergio Quevedo Teruel, Fernando Pineda de la Losa, Miriam Castillo Fernández, Luis Ángel Echeverría Zudaire TP38 Practical application of basophil activation test in children with food allergy Ekaterina Khaleva, Gennady Novic, Natalia Bychkova THEMATIC POSTER SESSION 3: Asthma (TP39–TP57) TP39 Effect of corticosteroid therapy upon serum magnesium level in chronic asthmatic children Amany Abd Al-Aziz, Amany Fatouh, Ayat Motawie, Eman El Bostany, Amr Ibrahim TP40 ADAM33 in Bulgarian children with asthma Guergana Petrova, Dimitrinka Miteva, Snezhina Lazova, Penka Perenovska, Sylvia Andonova, Alexey Savov TP41 TP42 The impact of vitamin D serum levels in asthma and allergic rhinitis Maria Zoto, Marialena Kyriakakou, Paraskevi Xepapadaki, Nikolaos G. Papadopoulos TP43 Life-threatening, first reported, paradoxical bronchospasm after nebulised Salbutamol in a 10 year old child Paraskevi Korovessi, Mariza Vassilopoulou, Athina Balaska, Lambros Banos, Stavroula Kostaridou, Despina Mermiri TP44 TP45 Asthma symptoms in children with treatment for allergic rhinoconjunctivitis Jorien Wartna, Arthur M. Bohnen, Gijs Elshout, David H. J. Pols, Patrick J. E. Bindels Erasmus MC, Rotterdam, The Netherlands TP46 Atopy increased the risk of developing exercise-induced bronchoconstriction in young athletes Sven F. Seys; Ellen Dilissen, Sarah Van der Eycken, An-Sofie Schelpe, Gudrun Marijsse, Thierry Troosters, Vincent Vanbelle, Sven Aertgeerts, Jan L. Ceuppens, Lieven J. Dupont, Koen Peers, Dominique M. Bullens TP47 The effect of higher BMI on risk for asthma and treatment outcome in overweight and obese children Ivana Banic, Sandra Bulat Lokas, Jelena Zivkovic, Boro Nogalo, Iva Mrkic Kobal, Davor Plavec, Mirjana Turkalj TP48 TP49 TP50 TP51 TP52 The impact of a multidisciplinary project intended to change the culture of nebulisers towards pressurised metered dose inhalers Georgeta Oliveira, Katharine Pike, Alda Melo, Tomás Amélia, José Carlos Cidrais Rodrigues, Cristina Serrano, José Manuel Lopes dos Santos, Carla Lopes TP53 TP54 TP55 TP56 Increased asthma control in patients with severe persistent allergic asthma after 12 month of nightly temperature controlled laminar airflow (TLA) Eckard Hamelmann, Uwe Schauer, Karl-Christian Bergmann TP57 THEMATIC POSTER SESSION 4: Drug allergy—Dermatology (TP58–TP77) TP58 Should we proceed directly to provocation challenges to diagnose drug allergy? Our experience says yes Luis Moral, Teresa Toral, Nuria Marco, Beléns García Avilés, Mª Jesús Fuentes, Jesús Garde, Cristina Montahud, Javier Perona, Mª José Forniés TP59 Anaphylaxis to 13-valent pneumococcal vaccine Esozia Arroabarren, Marta Anda, Maria Luisa Sanz, Maria Teresa Lizaso, Candida Arregui TP60 Intrapartum antibiotic exposure for treatment of group B streptococcus was not associated with the development of penicillin allergy in children Sara May, Martha Hartz, Avni Joshi, Miguel A. Park TP61 Evaluation of suspected drug hypersensitivity reactions in 169 children referred to the General Hospital Sonja Posega Devetak, Tina Vesel, Anja Koren Jeverica, Tadej Avčin TP62 Drug provocation testing: experience of a tertiary hospital Leonor Castro, Carolina Gouveia, Ana Carvalho Marques, Antonio Jorge Cabral TP63 Perioperative anaphylaxis: a growing concern in pediatric population Luis Amaral, Fabrícia Carolino, Eunice Castro, Madalena Passos, Josefina R. Cernadas TP64 Raising awareness of hypersensitivity to non-steroidal anti-inflammatory drugs in the pediatric age Fabrícia Carolino, Luís Amaral, Eunice Dias de Castro, Josefina R. Cernadas TP65 Perioperative anaphylaxis in young children: how to confirm the suspicion Josefina R. Cernadas, Fabrícia Carolino, Luís Amaral, Fernando Pineda, Armanda Gomes TP66 A case study of a child suspected to be penicillin allergic-digging deeper Katherine Knight, Roisin Fitzsimons, Helen Brough TP67 Prevalence, characteristics and risk factors of hypersensitivity reactions to antibiotics in patients with cystic fibrosis Jobst Röhmel, Carsten Schwarz, Anne Mehl, Philippe Stock, Doris Staab TP68 Antibiotic drug hypersensitivity in cystic fibrosis: A pilot study using cellular allergy tests for diagnostics Jobst Röhmel, Carsten Schwarz, Christine Seib, Doris Staab, Philippe Stock TP69 Oral antibiotics challenges in children Anita Critchlow, Alyson Barber, Nicola Jay TP70 Hypersensitivity reaction to vancomycin: a new successful desensitization protocol Belen Delavalle, Teresa Garriga, Blanca Vilá, Cristina Blasco TP71 TP72 Clinical phenotypes according to FLG gene loss of function mutations in children with atopic dermatitis Francesca Cipriani, Annalisa Astolfi, Costanza Di Chiara, Elisabetta Calamelli, Iria Neri, Annalisa Patrizi, Gianpaolo Ricci TP73 TP74 Urticaria in children: clinical and epidemiological features Katerina Neskorodova, Asya Kudryavtseva TP75 TP76 Acute urticaria at the Pediatrics Emergency Department: is it allergy? Esozia Arroabarren, Jorge Alvarez, Marta Anda, Miriam Palacios, Marta Martinez-Merino, Ibone Vaquero TP77
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- 2016
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74. Os factores genéticos da asma
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Videira, Paula Alexandra, primary, Borrego, Luís Miguel, additional, and Trindade, Hélder, additional
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- 2006
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75. Management of Childhood Urticaria: Current Knowledge and Practical Recommendations.
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PITE, Helena, WEDI, Bettina, BORREGO, Luís Miguel, KAPP, Alexander, and RAAP, Ulrike
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URTICARIA ,ANGIONEUROTIC edema ,SKIN inflammation ,SKIN diseases ,PEDIATRIC dermatology - Abstract
Urticaria, defined by the presence of wheals and/or angioedema, is a common condition in children, prompting parents to consult physicians. For its successful management, paediatric-specific features must be taken into account, regarding the identification of eliciting triggers and pharmacological therapy. This review systematically discusses the current best-available evidence on spontaneous acute and chronic urticaria as well as physical and other urticaria types in children. Potential underlying causes, namely infections, food and drug hypersensitivity, autoreactivity and autoimmune or other conditions, and eliciting stimuli are considered, with practical recommendations for specific diagnostic approaches. Second-generation antihistamines are the mainstay of pharmacological treatment aimed at relief of symptoms, which require dose adjustment for paediatric use. Other therapeutic interventions are also discussed. In addition, unmet needs are highlighted, aiming to promote research into the paediatric population, ultimately aiming at the effective management of childhood urticaria. [ABSTRACT FROM AUTHOR]
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- 2013
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76. One-year survey of anaphylaxis at pediatric age in an Immunoallergy department
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Gaspar, Ângela, Natacha Santos, Piedade, Susana, Santa-Marta, Cristina, Pires, Graça, Sampaio, Graça, Borrego, Luís Miguel, Arêde, Cristina, and Morais-Almeida, Mário
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criança ,children ,registo anual ,annual survey ,Adrenalina ,etiology ,etiologia ,notificação ,notification ,epinephrine ,anafilaxia ,Anaphylaxis - Abstract
Introdução: Existe uma crescente incidência de anafilaxia, especialmente em idade pediátrica, sendo a caracterização desta entidade dificultada pelo subdiagnóstico e subnotificação. Objectivo: Determinar a frequência de anafilaxia no ambulatório de um centro de Imunoalergologia, permitindo aumentar o conhecimento sobre etiopatogenia, manifestações e abordagem clínica em crianças e adolescentes. Métodos: De 3646 doentes com menos de 18 anos observados durante o ano de 2011, incluímos aqueles com quadros de anafilaxia voluntariamente notificados pelo corpo clínico (“pelo menos um episódio de reacção sistémica grave”). Resultados: Foram notificadas 64 crianças com história de anafilaxia (prevalência de 1,8%), com idade média de 8,1±5,5 anos, dos quais 61% do género masculino. A maioria (91%) tinha antecedentes pessoais de doença alérgica, 44% com asma. A idade mediana da primeira reacção anafiláctica foi aos 3 anos (1 mês a 17 anos). Em 14 crianças o primeiro episódio ocorreu no primeiro ano de vida. A maioria teve anafilaxia induzida por alimentos (84%): leite (n=22), ovo (n=7), amendoim (n=6), frutos secos (n=6), frutos frescos (n=6), crustáceos (n=4), peixe (n=4) e trigo (n=2). Em 2 adolescentes foi reportada anafilaxia induzida por exercício dependente de alimentos. A anafilaxia induzida por fármacos ocorreu em 8%: anti-inflamatórios não esteróides (n=4) e amoxicilina (n=1). Três crianças tiveram anafilaxia induzida pelo frio, uma adolescente teve anafilaxia ao látex e síndrome látex-frutos, e uma criança teve anafilaxia com picada de insecto. A maioria (73%) não tinha diagnóstico etiológico prévio. Os sintomas mais frequentes foram mucocutâneos (94%) e respiratórios (84%), seguidos de gastrintestinais (44%) e cardiovasculares (25%); 86% tiveram início nos primeiros 30 minutos após exposição ao factor causal; 51 (80%) recorreram a serviço de urgência, sendo que apenas 33% receberam tratamento com adrenalina. Houve recorrência de anafilaxia em 26 doentes (≥3 episódios em 14 crianças). Conclusões: Na nossa população pediátrica, a principal causa de anafilaxia foi a alergia alimentar IgE mediada. A adrenalina foi subutilizada, tal como tem sido referido por outros autores. Frequentemente as crianças têm vários episódios de anafilaxia antes de serem avaliadas pelo imunoalergologista. Enfatizamos a importância de um sistema de notificação de anafilaxia e do desenvolvimento de programas educacionais de forma a melhorar as estratégias de prevenção e tratamento desta entidade potencialmente fatal. Background: Anaphylaxis incidence is increasing, especially in the pediatric age group, being the characterization of this entity hampered by underdiagnosis and underreporting. Aim: To determine the frequency of anaphylaxis in an Immunoallergy outpatient department, allowing to a better understanding regarding aetiology, clinical manifestations and management, in children and adolescents. Methods: From 3646 patients up to 18 years old observed in our Immunoallergy department during 2011, we included those with history of anaphylaxis voluntarily reported by the clinical staff (“at least one episode of severe systemic reaction”). Results: During the one year period, 64 children had history of anaphylaxis (prevalence of 1.8%). Mean age was 8.1±5.5 years, with 61% being male. The majority (91%) had personal history of allergic disease, and 44% had asthma as co‑morbidity. Median age of the first anaphylactic episode was 3 years (1 month to 17 years old). In 14 children the first anaphylactic reaction occurred in the first year of life. The majority of patients had food‑induced anaphylaxis (84%): milk (n=22), egg (n=7), peanut (n=6), tree nuts (n=6), fresh fruits (n=6), crustaceans (n=4), fish (n=4) and wheat (n=2). Food‑associated exercise‑induced anaphylaxis was reported in 2 adolescents. Drug‑induced anaphylaxis occurred in 8%: non‑steroidal anti‑inflammatory drugs (n=4) and amoxicillin (n=1). Three children had cold‑induced anaphylaxis, one adolescent had anaphylaxis to latex and latex‑fruit syndrome, and one child had anaphylaxis to insect sting. The majority (73%) had no previous diagnosis of the etiologic factor. Symptoms reported were mainly mucocutaneous (94%) and respiratory (84%), followed by gastrointestinal (42%) and cardiovascular (25%); 86% beginning in the first 30 minutes after exposure to trigger agent. Fifty‑one (80%) patients were admitted to emergency department, although only 33% were treated with epinephrine. Recurrence of anaphylaxis occurred in 26 patients (3 or more episodes in 14 children). Conclusions: In our pediatric population, the main triggering agent of anaphylaxis was IgE‑mediated food allergy. Epinephrine is clearly underused, as has been reported by others. Often, children have several episodes before being assessed by an allergist. We stress the importance of systematic notification of anaphylaxis and improvement of educational programmes in order to achieve a better preventive and therapeutic management of this life‑threatening entity.
77. Populações linfocitárias no diagnóstico da Síndrome de Sjögren
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Barcelos, Filipe Alexandre Duarte, Branco, Jorge da Cunha, Borrego, Luís Miguel Nabais, and Borrego, Luís M.
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Medicina ,Síndrome de Sjögren primária ,Ciências Médicas ,Investigação Clínica - Abstract
A Síndrome de Sjögren primária (SSP) é uma doença inflamatória crónica, de origem autoimune, que se carateriza pela infiltração linfocitária e lesão das glândulas exócrinas.O diagnóstico diferencial entre uma síndrome seca de origem autoimune (SSP) ou não-autoimune (complexo Sicca) é o principal desafio no diagnóstico da SSP, tendo extrema importância no prognóstico e na terapêutica.Atualmente, os principais elementos para confirmar o componente autoimune da SSP são a presença de anticorpos anti-SSA e anti-SSB e de infiltrados linfocitários focais na biópsia de glândula salivar minor(labial). São desejáveis novos biomarcadores que traduzam a disfunção imune presente na SSP, pois nem sempre é fácil confirmar o diagnóstico, sobretudo nas fases precoces da doençaA hiperatividade das células B, suportada por células T, é responsável por algumas das caraterísticas clínicas e imunológicas mais reconhecíveis da doença, sendo sugerido na literatura que a avaliação de perfisde linfócitos específicos podeconstituir um elemento auxiliar no diagnóstico da SSP.A partir destes pressupostos, este trabalho teve como objetivo principal explorar das subpopulações linfocitárias (caraterizadas por citometria de fluxo), e a sua utilização como biomarcadores auxiliares no diagnóstico e classificação da SSP. Explorámos também a distribuição das subpopulações linfocitárias com os seguintes objetivos secundários: avaliar a sua relação com o status serológico da infeção pelo vírus Epstein-Barr (EBV); avaliar a sua relação com o perfil serológico (anti-SSA) e eventual associação a caraterísticas fenotípicas da SSP; avaliar a relação da morfologia do plexo nervoso corneano sub-basal, quer com o perfil linfocitário, quer com a atividade da doença na SSP.Para este efeito, foram incluídos 57 doentes com SSP classificados de acordo com os critérios do American-European Consensus Group(AECG ) (Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM et al. 2002), 68 doentes com síndrome Sicca sem critérios de SSP, 20 doentes com Artrite Reumatoide (AR) e 24 indivíduos saudáveis, sem queixas secas.A citometria de fluxo foi a metodologia utilizada na avaliação imunofenotípica das populações celulares, considerando também os ensaios funcionais, utilizados para a avaliação da produção de citocinas. Na abordagem dos níveis séricos de anticorpos, em particular no contexto da infeção por EBV, recorreu-se a ensaios imunoenzimáticos clássicos.Resumidamente, a avaliação imunofenotípica implicou a incubação de sangue periférico com um painel pré-validado de anticorpos monoclonais, otimizado para a caraterização de células T (incluindo várias subpopulações dentro das células T CD4 e T CD8, tais como células reguladoras e células foliculares), e de células B (assegurando a caraterização de diferentes estadios desdeas células de transição a células de memória e plasmablastos, ou células reguladoras, através de estratégias distintas como a classificação Bm1-5, frequentemente aplicada neste contexto). Foi ainda estudada a capacidade de as células T secretarem citocinas como a IL-17 e a IL-21, após estimulação com PMA e ionomicina. O painel de anticorpos monoclonais incluiu os seguintes marcadores: CD3, CD4, CD8, CD19, CD24, CD25, CD27, CD38, CD45, CD45RA, CCR6, CCR7, CXCR3, CXCR5, anti-IgD, anti-IgM. Por fim, para a obtenção de contagens absolutas, utilizou-se uma estratégia de plataforma única, com a utilização de tubos TruCountTM, com esferas calibradas.A aquisição das amostras foi efetuada num citómetro BD FACS CaliburTM(BD Biosciences, San Jose, CA, EUA), equipado com dois lasers, permitindo a avaliação de quatro fluorescências distintas. O software de aquisição foi o MultiSetTM(BD Biosciences), e para efeitos de análise, foram usados ainda os softwares Cell Quest 3.3TM(BD Biosciences) e InfynicytTM(Cytognos, Salamanca, Espanha). A análise estatística utilizou o programa Graph Pad Prism (GraphPad Software, San Diego, CA, EUA).Em linha com a literatura, no nosso estudo, a classificação clássica IgD/CD27 verificou a existência de uma redução dos números absolutos e percentagens de células B de memória (sobretudo sem switch) e aumento das células B naïve em doentes com SSP. A avaliação das células B de acordo com a classificação Bm1-Bm5 confirmou também o aumento das subpopulações Bm2 e Bm2 ́, e a diminuição das eBm5 e Bm5. Na razão entre as células Bm2+Bm2' e as eBm5+Bm5 foi possível aplicar cut-offs na discriminação entre SSP e controlos, ainda que com menor sensibilidade e especificidade em relação aos anteriormente descritos.Ainda assim, doentes com SSP com valores mais baixos células B de memória apresentavam maior frequência de caraterísticas fenotípicas da doença, como FS≥1, anticorpos anti-SSA, anticorpos anti-SSB, ANA e FR, e aumento das imunoglobulinas. Estes resultados, que se associam a menores valores de células B de memória e à disfunção autoimune na SSP estão de acordo com a hipótese de que a diferenciação das células B periféricas que migram para as glândulas salivares favorecem a formação de plasmócitos e a consequente produção de autoanticorpos.Verificámos também que os doentes Sicca apresentaram percentagens de células B naïve e de memória semelhantes às de doentes com SSP, e distintas das dos controlos, enquanto que os valores absolutos destas populações foram superiores aos da SSP, mas inferiores aos controlos. Considerando o desafio diagnóstico dos doentes Sicca, o seu perfil linfocitário intermédio entre SSP e controlos, evidente nos doentes Sicca, sugere a presença de disfunção imunológica, podendo alguns deles corresponder a formas ligeiras ou precoces de SSP.As células T foliculares efectoras (Tfh) têm um importante papel na patogénese da SSP, onde foi descrito um aumento das células Tfh circulantes e uma expansão da sua diferenciação nas GS (Li et al. 2012; Szabo et al. 2013). Ora, a marcada expansão de células Tfh e a simultânea presença de células Tfc nas glândulas salivares na SSP pode relacionar-se com mecanismos de resposta a um agente infecioso sialotrópico, como o EBV. Neste estudo, apesar dos números absolutos de células T CXCR5+estarem diminuídos na SSP, encontrámos um aumento das células T produtoras de IL-21, quer CD4+(Tfh), quer CD8+(Tfc). Além disso, as células Tfc estavam aumentadas nos doentes com SSP com maior atividade da doença, tendo sido possível identificar uma correlação positiva entre os números absolutos de células T IL21+CD8+e o ESSDAI, sugerindo um papel destas células na patogénese da doença. Curiosamente, o aumento das células T produtoras de IL-21 lembra o perfil de uma infeção viral crónica, e de facto, em relação aos marcadores serológicos de EBV, os doentes com SSP apresentaram maior prevalência de anti-EBV EA-D IgG, em comparação com doentes com AR e controlos saudáveis.Reconhecendo este aumento de prevalência de anti-EBV EA-D IgG e uma prevalência importante de anti-EBNA IgG em SSP, subdividimos estesdoentes em 3 grupos de acordo com o padrão serológico para EBV. Doentes com serologia positiva para EBV apresentavam ESSDAI superior ao de doentes sem evidência de infeção (G3). Em doentes com perfil serológico de infeção recente/reativação de EBV, a frequência de doentes com PSS ativa era também tendencionalmente superior à dos doentes com infeção antiga. Do ponto de vista celular também se verificaram alterações, com os doentes com evidência de infeção por EBV, em especial infeção recente/reativação, a apresentarem maior representação das subpopulações T pro-inflamatórias Th1 e Tfh1, o que pode indicar a influência viral na diferenciação preferencial destas células. Adicionalmente, doentes com infeção por EBV recente/reativação apresentavam níveis superiores de células B de transição e de plasmablastos, o que pode indicar a influência do EBV na modulação das respostas imunes na SSP e na expressão clínica, conforme sugerido pela manifestação mais precoce da doença e maior frequência de doença ativa nestes indivíduos....
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- 2021
78. O doente drepanocítico: a modulação da resposta imune e a susceptibilidade para a síndrome torácica aguda
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Toader, Ionela Alexandra Filofteia, MARTINS, Catarina, and BORREGO, Luís Miguel
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Síndrome torácica aguda ,Microbiologia médica ,Perfil imune ,Drepanocitose ,Ciências Médicas [Domínio/Área Científica] ,Hidroxiureia ,Citometria de fluxo ,Biologia molecular - Abstract
A Drepanocitose, Doença das Células Falciformes (DCF), é uma hemoglobinopatia caracterizada pela mutação do gene da β hemoglobina, em que a molécula normal hemoglobina (HbA) sofre alteração para a forma de hemoglobina S (HbS). Estes doentes apresentam maior suscetibilidade a infeções, com alterações reportadas na imunidade inata e na imunidade adaptativa. Concretamente encontram-se nestes doentes, deficiências na secreção de IgM, diminuição as células B de memória IgM+, células T CD4 e T CD8, e aumento das células de T CD4 de Memória. Também os níveis séricos de MBL e CD40L se encontram alterados. No doente drepanocítico, a Síndrome Torácica Aguda (STA) é das principais causas de internamento, morbilidade e mortalidade, surgindo por causa infeciosa, mas também na sequência de crises vaso-oclusivas, características destes doentes. Do ponto de vista da terapêutica, a Hidroxiureia é um dos fármacos de eleição. O objetivo deste estudo foi a caracterização do perfil imune da população pediátrica com Drepanocitose do Hospital D. Estefânia – Centro Hospitalar de Lisboa Central (HDE), e a posterior avaliação deste perfil em função da ocorrência de STA e da instituição de Hidroxiureia. Assim, foram recolhidas amostras de sangue de 30 doentes diagnosticadas com Drepanocitose, analisadas no Laboratório de Imunologia da NMS|FCM. Foram avaliadas distintas populações celulares por Citometria de Fluxo, e em particular foi utilizado o tubo PIDOT, do consórcio Euroflow, com a respetiva base de dados. Foram também utilizadas técnicas imunoenzimáticas e imunofluorescentes para o doseamento dos mediadores solúveis MBL e CD40L. Para esta avaliação foram utilizados soros controlo do Laboratório de Imunologia, obtidos a partir de uma população pediátrica saudável acompanhada no HDE. O grupo de doentes foi posteriormente dividido de acordo com a história de STA e com a instituição ou não de Hidroxiureia. Na generalidade dos doentes, as subpopulações celulares apresentaram-se dentro dos valores de referência da Base de Dados EuroFlow, com as alterações observadas em alguns doentes a traduzir o descrito na literatura. Em relação à ocorrência de episódios de STA, apenas a população de células dendríticas plasmacitoides se apresentou diminuída nos doentes com história de STA, o que pode representar um possível elemento a considerar do ponto de vista de marcadores de risco. Em relação à terapêutica com Hidroxiureia, observou-se diminuição de células T CD4+ Memória Central e Efetoras, bem como de Monócitos e Basófilos nos doentes com terapêutica, que também evidenciaram valores mais elevados de células T TCRγδ. Estes elementos, devidamente confirmados poderão vir a ter aplicação futura na monitorização da terapêutica, do ponto de vista da resposta imune. Relativamente à avaliação dos marcadores séricos, observou-se diminuição de MBL e aumento de CD40L nos doentes, ao encontro do que tem sido descrito. Não houve alterações nas comparações de doentes com e sem STA, e com e sem terapêutica. Em conclusão, este estudo pioneiro na aplicação das estratégias EuroFlow ao doente com Drepanocitose, suporta a sua aplicabilidade no acompanhamento destes doentes, nomeadamente na avaliação potenciais fatores de risco para o desenvolvimento de STA e na avaliação da eficácia da terapêutica, a nível da resposta imune. Sickle Cell Disease (SCD) is an hemoglobinopathy characterized by the mutation of the β-hemoglobin gene, in which the normal hemoglobin (HbA) molecule changes to the hemoglobin S (HbS) form. These patients are more susceptible to infections, with reported changes in innate immunity and adaptive immunity. Specifically, in these patients there are deficiencies in IgM secretion, decrease in IgM+ memory B cells, CD4 and CD8 T cells, and increased Memory CD4 T cells. Also, the serum levels of MBL and CD40L are altered. In patients with sickle cell disease, Acute Chest Syndrome (ACS) is the main cause of hospitalization, morbidity and mortality, arising from infectious causes, but also from vaso-occlusive crises, which are characteristic of these patients. From the therapeutic point of view, Hydroxyurea is one of the drugs of choice. The aim of this study was to characterize the immune profile of the pediatric population with Drepanocytosis of the Hospital D. Estefânia - Centro Hospitalar de Lisboa Central (HDE), and the subsequent evaluation of this profile according to the occurrence of ACS and the use of Hydroxyurea. Blood samples were collected from 30 patients diagnosed with Drepanocytosis and were analyzed at the Immunology Laboratory of NMS | FCM. Distinct cell populations were evaluated by Flow Cytometry, and in particular the PIDOT tube from the EuroFlow consortium was used with its Database. Immunoenzymatic and immunofluorescent techniques were also used for the determination of the soluble mediators MBL and CD40L. For this evaluation control sera from the Immunology Laboratory were used, obtained from a healthy pediatric population followed at HDE. Patients were further divided according to the history of ACS and to the use Hydroxyurea. In most patients, cell subpopulation presented values within the reference values of the EuroFlow Database, with the alterations observed in some cases translating what has been reported in literature. As for the occurrence of ACS, only the population of plasmacytoid dendritic cells was decreased in patients with a history of ACS, which may represent a possible element to be considered as a risk marker for the occurrence of ACS. Regarding the use of Hydroxyurea, decreased Central and Effector Memory CD4+ T, as well as Monocytes and Basophils were observed in patients under therapy, which also presented increased TCRγδ T cells. These elements, properly confirmed, may have future application in monitoring the effect of therapy from the immune point of view. Regarding the evaluation of serum markers, a decrease in MBL serum levels and an increase in CD40L serum levels were observed, in accordance with data from previous reports. In brief, this study, using for the first time the EuroFlow strategies in patients with SCD, supports the application of these platforms in this disease, namely in the evaluation of potential risk markers for the development of ACS, and even in the evaluation of therapeutics efficacy from the immune point of view.
- Published
- 2019
79. Modelos de regressão para identificação de marcadores preditivos de asma na descendência de mulheres com atopia
- Author
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Domingues, Tiago Miguel Dias, Diamantino, Maria Fernanda Nunes, 1961, and Borrego, Luís Miguel Nabais, 1973
- Subjects
Parâmetros imunológicos ,Análise de regressão ,Gravidez ,Trabalhos de projecto de mestrado - 2016 ,Atopia ,Departamento de Estatística e Investigação Operacional - Abstract
Trabalho de projecto de mestrado, Bioestatística, Universidade de Lisboa, Faculdade de Ciências, 2016 Submitted by Teresa Boa (tdboa@fc.ul.pt) on 2016-06-23T14:59:17Z No. of bitstreams: 1 ulfc118311_tm_Tiago_Domingues.pdf: 1863772 bytes, checksum: 3c99242a9c23f9b797abb7180ec8247e (MD5) Made available in DSpace on 2016-06-23T14:59:30Z (GMT). No. of bitstreams: 1 ulfc118311_tm_Tiago_Domingues.pdf: 1863772 bytes, checksum: 3c99242a9c23f9b797abb7180ec8247e (MD5) Previous issue date: 2016
- Published
- 2016
80. Estudo de células T ativadas e células B reguladoras no último trimestre da gravidez
- Author
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Gomes, Joana Ferreira, Borrego, Luís Miguel, and Caniça, Manuela
- Subjects
Gravidez ,Células T ,Células B - Abstract
Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz Introdução: Um dos principais enigmas da biologia reprodutiva centra-se no facto de mulheres com sistema imunitário competente conseguirem completar uma gravidez semi-alogénica. Vários mecanismos têm sido envolvidos na tolerância imune materno-fetal. Contudo, nenhum consegue explicar este processo só por si. Assim, o presente estudo tenta completar a abordagem de parâmetros imunes, incorporando a avaliação dos componentes B e T. Material e métodos: Participaram no estudo 20 mulheres não grávidas, saudáveis e em idade fértil e 20 mulheres grávidas saudáveis no terceiro trimestre de gestação. Foram analisadas, por citometria de fluxo, amostras de sangue periférico de cada participante para determinação da expressão em linfócitos T de CD25 e HLA-DR e em linfócitos B de CD24, CD27, CD38 e produção de IL10. Resultados e discussão: Da comparação das grávidas com o grupo controlo não se observaram diferenças estatisticamente significativas nas populações CD25+. Observou-se diminuição estatisticamente significativa da população CD3+CD4+HLA-DR+. O grupo de grávidas foi analisado ainda dividido em dois subgrupos: grávidas de primeira gestação e grávidas com pelo menos 1 gestação anterior, verificando-se que a diminuição registada inicialmente se devia particularmente ao grupo de grávidas em primeira gravidez. Observou-se uma diminuição estatisticamente significativa das populações de linfócitos B CD19+CD24hiCD38hi, CD19+CD24hiCD27+ e CD19+CD24hiCD27hi. Não se observou variação estatisticamente significativa na produção de IL10. Estes resultados podem dever-se à diminuição da concentração de HCG no terceiro trimestre de gravidez, dado o seu papel na promoção da proliferação das Bregs. Conclusões: Durante a gravidez, verifica-se uma diminuição das subpopulações de células B. Verificou-se ainda, particularmente nas primíparas, uma diminuição da população CD3+CD4+HLA-DR+. O esclarecimento dos mecanismos de ativação e regulação envolvidos na tolerância imunológica, permitirão no futuro uma análise mais consistente e uma melhor compreensão da interface materno-fetal.
- Published
- 2014
81. Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity.
- Author
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Castela I, Morais J, Barreiros-Mota I, Silvestre MP, Marques C, Rodrigues C, Ismael S, Araújo JR, Ângelo-Dias M, Martins C, Borrego LM, Monteiro R, Coutinho SR, Calhau C, Martins C, Faria A, Pestana D, and Teixeira D
- Subjects
- Humans, Adiponectin metabolism, Reproducibility of Results, Obesity metabolism, Body Mass Index, Triglycerides, Leptin metabolism, Insulin Resistance physiology
- Abstract
Adipose tissue dysfunction is a key mechanism that leads to adiposity-based chronic disease. This study aimed to investigate the reliability of the adiponectin/leptin ratio (AdipoQ/Lep) as an adipose tissue and metabolic function biomarker in adults with obesity, without diabetes. Data were collected from a clinical trial conducted in 28 adults with obesity (mean body mass index: 35.4 ± 3.7 kg/m
2 ) (NCT02169778). With the use of a forward stepwise multiple linear regression model to explore the relationship between AdipoQ/Lep and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), it was observed that 48.6% of HOMA-IR variance was explained by triacylglycerols, AdipoQ/Lep, and waist-to-hip ratio ( P < 0.001), AdipoQ/Lep being the strongest independent predictor (Beta = -0.449, P < 0.001). A lower AdipoQ/Lep was correlated with higher body mass index ( Rs = -0.490, P < 0.001), body fat mass ( Rs = -0.486, P < 0.001), waist-to-height ratio ( Rs = -0.290, P = 0.037), and plasma resistin ( Rs = -0.365, P = 0.009). These data highlight the central role of adipocyte dysfunction in the pathogenesis of insulin resistance and emphasize that AdipoQ/Lep may be a promising early marker of insulin resistance development in adults with obesity. NEW & NOTEWORTHY Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context of obesity. This study provides evidence to support adipose tissue dysfunction as a central feature of the pathophysiology of obesity and insulin resistance. Early identification of individuals at higher risk of developing metabolic complications through adipose tissue dysfunction assessment and the staging of obesity and its transient phenotypes can contribute to improve therapeutic decision-making.- Published
- 2023
- Full Text
- View/download PDF
82. [Asthma genetic factors].
- Author
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Videira PA, Borrego LM, and Trindade H
- Subjects
- Genetic Predisposition to Disease, Humans, Pharmacogenetics, Asthma genetics
- Abstract
Asthma is a chronic inflammatory airways disease, with a rising prevalence, particularly in childhood, and is considered an important public health problem. Its familial transmission is recognised, while the description and identification of the genes implicated in this disease are a challenge. In this revision paper the authors give a comprehensive explanation of the associated genes as well as the laboratorial methods that allow their identification.
- Published
- 2006
- Full Text
- View/download PDF
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