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Protein therapeutics are in great demand due to their effectiveness towards hard-to-treat diseases. Despite their high demand, these bio-therapeutics are very susceptible to degradation via aggregation, fragmentation, oxidation, and reduction, all of which are very likely to affect the quality and efficacy of the product. Mechanisms and modelling of these degradation (aggregation and fragmentation) pathways is critical for gaining a deeper understanding of stability of these products. This review aims to provide a summary of major developments that have occurred towards unravelling the mechanisms of size-based protein degradation (particularly aggregation and fragmentation), modelling of these size-based degradation pathways, and their control. Major caveats that remain in our understanding and control of size-based protein degradation have also been presented and discussed.

Developing efficient adsorbents for the removal of AsH3 is of paramount importance. In this study, we employed density functional theory calculations to devise novel adsorbents capable of effectively capturing AsH3, thereby gaining comprehensive insights into the adsorption mechanism of AsH3 on silicon carbide (SiC). It is found that AsH3 molecules are chemically attached to the SiC with an adsorption energy of around -0.67 eV. Also, the process of adsorbing AsH3 molecules increased the electrical conductivity of the SiC nanosheet. According to our results, the charge transfers occur from SiC to AsH3, demonstrating the strong AsH3 interactions with SiC monolayers. Based on various structural and electronic features, one can understand that the reactivity of SiC for AsH3 adsorption is strong. The suggested method of AsH3 molecules being adsorbed onto SiC provides cutting-edge approaches for designing adsorbents to remove AsH3 on an industrial scale. [ABSTRACT FROM AUTHOR]

Byline: Rohit. Bansal, Kanwarjit. Dhillon, Gourav. Kaushal Laparoscopic splenectomy has become an established standard of care in managing surgical diseases of the normal-sized spleen. Natural orifice transluminal endoscopic surgery (NOTES) [...]

For marketers, the digital world offers a plethora of novel opportunities. Marketing in the modern day is all about relationships, involvement and relevancy. Digital marketing is the practice of marketers promoting goods and services through electronic media. The main objective of this study is to study the perception of customers towards digital marketing strategies implemented in the banking sector. Data were gathered from 535 banking customers by transmitting the questionnaire via Google Forms and handing out printed copies of the questionnaire. Results suggested that customers perceive digital marketing strategies as informative, interactive, entertaining and trustworthy but not offensive and personalised. Further, it was found that there is no significant difference among customers of different educational levels and occupations regarding customer perception towards digital marketing while a significant difference was found among customers based on age and income level. This analysis adds a great deal to the body of knowledge on marketing and has useful implications for marketing professionals as comprehending the perception of customers towards digital marketing may assist them in anticipating the usage of digital marketing. [ABSTRACT FROM AUTHOR]