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54. Geriatric Oncology as an Unmet Workforce Training Need in the United Kingdom—A Narrative Review by the British Oncology Network for Undergraduate Societies (BONUS) and the International Society of Geriatric Oncology (SIOG) UK Country Group

Author

Khoury, Emma G., primary, Nuamek, Thitikorn, additional, Heritage, Sophie, additional, Fulton-Ward, Taylor, additional, Kucharczak, Joanna, additional, Ng, Cassandra, additional, Kalsi, Tania, additional, Gomes, Fabio, additional, Lind, Michael J., additional, Battisti, Nicolò M. L., additional, Cheung, Kwok-Leung, additional, Parks, Ruth, additional, Pearce, Jessica, additional, and Baxter, Mark A., additional

Published
2023
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55. Hippocampal timestamp for goals

Author

Montagrin, Alison, primary, Croote, Denise E., additional, Preti, Maria Giulia, additional, Lerman, Liron, additional, Baxter, Mark G., additional, and Schiller, Daniela, additional

Published
2023
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64. Female Sex but Not Oestrogen Receptor Expression Predicts Survival in Advanced Gastroesophageal Adenocarcinoma—A Post-hoc Analysis of the GO2 Trial

Author

Baxter, Mark A., Spender, Lindsay C., Walsh, Shaun, Bray, Susan, Skinner, Gemma, King, Sharon, Hall, Peter S., Seymour, Matthew J., and Petty, Russell D.

Subjects
astroesophageal cance, prognosis, biomarkr, older adults, oestrogen receptor
Abstract

Gastroesophageal adenocarcinoma is a disease of older adults that is associated with a very poor prognosis. It is less common and has better outcomes in females. The reason for this is unknown but may relate to signalling via the main oestrogen receptors (ER) α and β. In this study, we sought to investigate this using the GO2 clinical trial patient cohort. GO2 recruited older and/or frail patients with advanced gastroesophageal cancer. Immunohistochemistry was performed on tumour samples from 194 patients. The median age of the population was 76 years (range 52–90), and 25.3% were female. Only one (0.5%) tumour sample was positive for ERα, compared to 70.6% for ERβ expression. There was no survival impact according to ERβ expression level. Female sex and younger age were associated with lower ERβ expression. Female sex was also associated with improved overall survival. To our knowledge, this is the largest study worldwide of ER expression in a cohort of patients with advanced gastroesophageal adenocarcinoma. It is also unique, given the age of the population. We have demonstrated that female sex is associated with better survival outcomes with palliative chemotherapy but that this does not appear to be related to ER IHC expression. The differing ER expression according to age supports the concept of a different disease biology with age.

Published
2023

65. Development of prefrontal corticostriatal connectivity in mice

Author

Mesías, Roxana E., primary, Zaki, Yosif, additional, Guevara, Christopher A., additional, Friedman, Lauren G., additional, Hussein, Ayan, additional, Therrien, Karen, additional, Magee, Alexandra R., additional, Tzavaras, Nikolaos, additional, Valle, Pamela Del, additional, Baxter, Mark G., additional, Huntley, George W., additional, and Benson, Deanna L., additional

Published
2023
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66. Temporary treatment cessation versus continuation of first-line tyrosine kinase inhibitor in patients with advanced clear cell renal cell carcinoma (STAR): an open-label, non-inferiority, randomised, controlled, phase 2/3 trial

Author

Brown, Janet E, primary, Royle, Kara-Louise, additional, Gregory, Walter, additional, Ralph, Christy, additional, Maraveyas, Anthony, additional, Din, Omar, additional, Eisen, Timothy, additional, Nathan, Paul, additional, Powles, Tom, additional, Griffiths, Richard, additional, Jones, Robert, additional, Vasudev, Naveen, additional, Wheater, Matthew, additional, Hamid, Abdel, additional, Waddell, Tom, additional, McMenemin, Rhona, additional, Patel, Poulam, additional, Larkin, James, additional, Faust, Guy, additional, Martin, Adam, additional, Swain, Jayne, additional, Bestall, Janine, additional, McCabe, Christopher, additional, Meads, David, additional, Goh, Vicky, additional, Min Wah, Tze, additional, Brown, Julia, additional, Hewison, Jenny, additional, Selby, Peter, additional, Collinson, Fiona, additional, Carser, Judith, additional, Srinivasan, Gopalakrishnan, additional, Thistlewaite, Fiona, additional, Azzabi, Ashraf, additional, Beresford, Mark, additional, Farrugia, David, additional, Decatris, Marios, additional, Thomas, Carys, additional, Gale, Joanna, additional, McAleer, James, additional, Clayton, Alison, additional, Boleti, Ekaterini, additional, Geldart, Thomas, additional, Sundar, Santhanam, additional, Lester, Jason, additional, Palaniappan, Nachi, additional, Hingorani, Mohan, additional, Rehman, Khaliq, additional, Khan, Mohammad, additional, Sarwar, Naveed, additional, Graham, Janine, additional, Thomson, Alastair, additional, Srihari, Narayanan, additional, Sheehan, Denise, additional, Srinivasan, Rajaguru, additional, Khan, Omar, additional, Jane Worlding, Andrew Stockdale, additional, Boussios, Stergios, additional, Stuart, Nicholas, additional, MacDonald-Smith, Carey, additional, Danwata, Falalu, additional, McLaren, Duncan, additional, Sundaramurthy, Aravindhan, additional, Lydon, Anna, additional, Beesley, Sharon, additional, Lees, Kathryn, additional, Varughese, Mohini, additional, Gray, Emma, additional, Scott, Angela, additional, Baxter, Mark, additional, Mullard, Anna, additional, Innominato, Pasquale, additional, Kapur, Gaurav, additional, Kumar, Anil, additional, Charnley, Natalie, additional, Manetta, Caroline, additional, Chakraborti, Prabir, additional, Das, Prantik, additional, Rudman, Sarah, additional, Taylor, Henry, additional, Mikropoulos, Christos, additional, Highley, Martin, additional, Muthukumar, Dakshinamoorthy, additional, Zarkar, Anjali, additional, Vergis, Roy, additional, Sriprasad, Seshadri, additional, Brulinski, Patryk, additional, Clarke, Amanda, additional, Osbourne, Richard, additional, Harvey, Melanie, additional, Dega, Renata, additional, Sparrow, Geoffrey, additional, Barthakur, Urmila, additional, Beaumont, Erica, additional, Michael, Agnieszka, additional, Porfiri, Emilio, additional, Azam, Faisal, additional, and Kodavtiganti, Ravi, additional

Published
2023
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67. Diagnosis, treatment, and outcome of patients with oesophagogastric cancer during the COVID-19 pandemic: national study

Author

Baxter, Mark A, primary, Khan, Khurram S, additional, Gall, Lewis S, additional, Samuelson, Catherine, additional, McCollum, Catherine, additional, Chuntamongkol, Rongkagorn, additional, Narramneni, Lakshmi R, additional, Al-Zuabi, Manaf, additional, Bryce, Gavin, additional, Shareef, Hala E J, additional, Forshaw, Matthew, additional, and Petty, Russell D, additional

Published
2023
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72. OGC P10 Stage Migration, Changed Treatment Profile and Survival Impact in Newly Diagnosed Oesophago-gastric Cancer in Scotland during the COVID-19 Pandemic – A National study

Author

Khan, Khurram, primary, Baxter, Mark, additional, Gall, Lewis, additional, Samuelson, Catherine, additional, Narramneni, Lakshmi, additional, Al-Zuabi, Manaf, additional, Bryce, Gavin, additional, Shareef, Hala, additional, Petty, Russell, additional, and Forshaw, Matthew, additional

Published
2022
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76. A national study of 23 major trauma centres to investigate the effect of frailty on clinical outcomes in older people admitted with serious injury in England (FiTR 1): a multicentre observational study

Author

Carter, Ben, primary, Short, Roxanna, additional, Bouamra, Omar, additional, Parry, Frances, additional, Shipway, David, additional, Thompson, Julian, additional, Baxter, Mark, additional, Lecky, Fiona, additional, and Braude, Philip, additional

Published
2022
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85. Flooring for Schools: Unsightly Walkways

Author

Baxter, Mark

Abstract

Many mattress manufacturers recommend that consumers rotate their mattresses at least twice a year to help prevent soft spots from developing and increase the product's life span. It's unfortunate that the same kind of treatment can't be applied to flooring for schools, such as carpeting, especially in hallways. Being able to flip or turn a carpet might delay or prevent what commonly is referred to as traffic-lane soiling, an unsightly problem that often afflicts carpeting in public facilities. This is when carpeting becomes dark and soiled, usually in the center of a major walkway, and especially when compared with its outer edges. In fact, it is not uncommon for the outer edges of carpeting in heavily trafficked areas to look virtually brand-new, while the center area may be dark, grimy, worn, spotted and even torn. This article discusses specific measures that can help facility managers prevent or delay school traffic-lane soiling.

Published
2011

86. Ensemble remodeling supports memory-updating

Author

Mau, William, primary, Morales-Rodriguez, Denisse, additional, Dong, Zhe, additional, Pennington, Zachary T., additional, Francisco, Taylor, additional, Baxter, Mark G., additional, Shuman, Tristan, additional, and Cai, Denise J., additional

Published
2022
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91. Perseverative Interference with Object-in-Place Scene Learning in Rhesus Monkeys with Bilateral Ablation of Ventrolateral Prefrontal Cortex

Author

Baxter, Mark G., Browning, Philip G. F., and Mitchell, Anna S.

Abstract

Surgical disconnection of the frontal cortex and inferotemporal cortex severely impairs many aspects of visual learning and memory, including learning of new object-in-place scene memory problems, a monkey model of episodic memory. As part of a study of specialization within prefrontal cortex in visual learning and memory, we tested monkeys with bilateral ablations of ventrolateral prefrontal cortex in object-in-place scene learning. These monkeys were mildly impaired in scene learning relative to their own preoperative performance, similar in severity to that of monkeys with bilateral ablation of orbital prefrontal cortex. An analysis of response types showed that the monkeys with lesions were specifically impaired in responding to negative feedback during learning: The post-operative increase in errors was limited to trials in which the first response to each new problem, made on the basis of trial and error, was incorrect. This perseverative pattern of deficit was not observed in the same analysis of response types in monkeys with bilateral ablations of the orbital prefrontal cortex, who were equally impaired on trials with correct and incorrect first responses. This may represent a specific signature of ventrolateral prefrontal involvement in episodic learning and memory.

Published
2008
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94. Mortality Among Adults With Cancer Undergoing Chemotherapy or Immunotherapy and Infected With COVID-19

Author

Várnai, Csilla, Palles, Claire, Arnold, Roland, Curley, Helen M., Purshouse, Karin, Cheng, Vinton W. T., Booth, Stephen, Campton, Naomi A., Collins, Graham P., Hughes, Daniel J., Kulasekararaj, Austin G., Lee, Alvin J. X., Olsson-brown, Anna C., Sharma-oates, Archana, Van Hemelrijck, Mieke, Lee, Lennard Y. W., Kerr, Rachel, Middleton, Gary, Cazier, Jean-baptiste, Pugh, Sian, Corrie, Pippa, Bedair, Ahmed, Hewish, Madeleine, Leonard, Pauline, Illingworth, Jack, Hibbs, Stephen, Diamantis, Nicolaos, Massalha, Samah, Fuller, Claire, Usbourne, Caroline, Gilbert, Duncan, Davies, Jennifer, Newsom-davis, Tom, Sharkey, Rachel, Lee, Rebecca, Tivey, Ann, Shotton, Rohan, Griffin, Clare, Horsley, Laura, Shamas, Simon, Sacco, Joseph J, Choudhury, Madbuba, Noble, Jillian, Shaw, Heather, Bolton, Rachel, Ferreira, Ana, Hall, Peter, Ramage, Paul, Bhosle, Jaishree, Massey, Alison, Hill, Michaela, Mukherjee, Leena, Ghaus, Aisha, Derby, Sarah, Brown, Sean, Lowndes, Sarah, Dolly, Saorise, Russell, Beth, Moss, Charlotte, Muller, Daniel, Pillai, Annet, Lowe, Shakeel, Cook, Lucy, Scrase, Christopher, Jyothirmayi, Rema, Board, Ruth, Cornthwaite, Stephanie, Parikh, Shefail, Cattell, Emma, Cox, Nicola, Gault, Abigail, Moody, Sam, Dobeson, Caroline, Baxter, Mark, Roques, Tom, Pawsey, Alexander, Oakes, Roderick, Melcher, Lucinda, Chan, Olivia, Ayers, Sarah, Bowyer, Helen, Althohami, Mohammed, Mittal, Sajjan, Feeney, Laura, Aujayeb, Avinash, Sheikh, Omar, Kathirgamakarthigeyan, Sangary, Woodcock, Victoria, Holt, Francesca, Wyatt, Simon, Topping, Oliver, Tilby, Michael, Bhattacharyya, Madhumita, Burke, Emma, Ellis, Shawn, Chacko, Joseph, Rabbi, Taslima, Rowe, Michael, Sargent, Rebecca, Thirlwell, Christina, Gibson, Jack, Goldstein, Robert, Fittall, Mathew, Gennatas, Spyridon, Okines, Alicia, Best, James, Tillett, Tania, Renninson, Emily, Grumett, Simon, Barrington, Craig, Pettengell, Ruth, Peng, Yingyying, Chackathayil, Julia, Akingboye, Akinfemi, Hollis, Helen, Shin Chin, Ik, Bisht, Vartika, Hartley, Simon, Middleton, Christopher P, Goel, Anshita, Protheroe, Emily, Naksukpaiboon, Paingfan, Anil, Iris, Michell, Joel, D'costa, Jamie, Wu, Anjui, Ottaviani, Diego, Soosaipillai, Gehan, Galazi, Myria, Chopra, Neha, Benafif, Sarah, Sng, Christopher Ct, Wong, Sophia Yn, Scott-brown, Martin, Copson, Ellen, Robinson, Timothy, Hudson, Zoe, Smith, Fiona, Abdulnabi Mohamed, Ali-abdulnabi, Angelakas, Angelos, Eastlake, Leoni, Poon-king, Ashley, Brunner, Clair, Kwan, Amy, Maynard, Alec, Boyce, Hayley, Spurrell, Emma, Peck, Rahul, and Kurec, Bartlomiej

Subjects
Aged, 80 and over, Male, Lung Neoplasms, SARS-CoV-2, COVID-19, General Medicine, Middle Aged, United Kingdom, Cohort Studies, Drug Therapy, Hematologic Neoplasms, Humans, Female, Immunotherapy, Prospective Studies, Registries, Aged
Abstract

Importance Large cohorts of patients with active cancers and COVID-19 infection are needed to provide evidence of the association of recent cancer treatment and cancer type with COVID-19 mortality.Objective To evaluate whether systemic anticancer treatments (SACTs), tumor subtypes, patient demographic characteristics (age and sex), and comorbidities are associated with COVID-19 mortality.Design, Setting, and Participants The UK Coronavirus Cancer Monitoring Project (UKCCMP) is a prospective cohort study conducted at 69 UK cancer hospitals among adult patients (≥18 years) with an active cancer and a clinical diagnosis of COVID-19. Patients registered from March 18 to August 1, 2020, were included in this analysis.Exposures SACT, tumor subtype, patient demographic characteristics (eg, age, sex, body mass index, race and ethnicity, smoking history), and comorbidities were investigated.Main Outcomes and Measures The primary end point was all-cause mortality within the primary hospitalization.Results Overall, 2515 of 2786 patients registered during the study period were included; 1464 (58%) were men; and the median (IQR) age was 72 (62-80) years. The mortality rate was 38% (966 patients). The data suggest an association between higher mortality in patients with hematological malignant neoplasms irrespective of recent SACT, particularly in those with acute leukemias or myelodysplastic syndrome (OR, 2.16; 95% CI, 1.30-3.60) and myeloma or plasmacytoma (OR, 1.53; 95% CI, 1.04-2.26). Lung cancer was also significantly associated with higher COVID-19–related mortality (OR, 1.58; 95% CI, 1.11-2.25). No association between higher mortality and receiving chemotherapy in the 4 weeks before COVID-19 diagnosis was observed after correcting for the crucial confounders of age, sex, and comorbidities. An association between lower mortality and receiving immunotherapy in the 4 weeks before COVID-19 diagnosis was observed (immunotherapy vs no cancer therapy: OR, 0.52; 95% CI, 0.31-0.86).Conclusions and Relevance The findings of this study of patients with active cancer suggest that recent SACT is not associated with inferior outcomes from COVID-19 infection. This has relevance for the care of patients with cancer requiring treatment, particularly in countries experiencing an increase in COVID-19 case numbers. Important differences in outcomes among patients with hematological and lung cancers were observed

Published
2022

97. Extensive Lesions of Cholinergic Basal Forebrain Neurons Do Not Impair Spatial Working Memory

Author

Vuckovich, Joseph A., Semel, Mara E., and Baxter, Mark G.

Abstract

A recent study suggests that lesions to all major areas of the cholinergic basal forebrain in the rat (medial septum, horizontal limb of the diagonal band of Broca, and nucleus basalis magnocellularis) impair a spatial working memory task. However, this experiment used a surgical technique that may have damaged cerebellar Purkinje cells. The present study tested rats with highly selective lesions of cholinergic neurons in all major areas of the basal forebrain on a spatial working memory task in the radial arm maze. In postoperative testing, there were no significant differences between lesion and control groups in working memory, even with a delay period of 8 h, with the exception of a transient impairment during the first 2 d of postoperative testing at shorter delays (0 or 2 h). This finding corroborates other results that indicate that the cholinergic basal forebrain does not play a significant role in spatial working memory. Furthermore, it underscores the presence of intact memory functions after cholinergic basal forebrain damage, despite attentional impairments that follow these lesions, demonstrated in other task paradigms. (Contains 1 table and 4 figures.)

Published
2004
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98. Septohippocampal Acetylcholine: Involved in but Not Necessary for Learning and Memory?

Author

Parent, Marise B. and Baxter, Mark G.

Abstract

The neurotransmitter acetylcholine (ACh) has been accorded an important role in supporting learning and memory processes in the hippocampus. Cholinergic activity in the hippocampus is correlated with memory, and restoration of ACh in the hippocampus after disruption of the septohippocampal pathway is sufficient to rescue memory. However, selective ablation of cholinergic septohippocampal projections is largely without effect on hippocampal-dependent learning and memory processes. We consider the evidence underlying each of these statements, and the contradictions they pose for understanding the functional role of hippocampal ACh in memory. We suggest that although hippocampal ACh is involved in memory in the intact brain, it is not necessary for many aspects of hippocampal memory function.

Published
2004

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