72 results on '"Beccaria, Kévin"'
Search Results
52. Blood-brain barrier disruption with low-intensity pulsed ultrasound for the treatment of pediatric brain tumors: a review and perspectives
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Beccaria, Kévin, primary, Canney, Michael, additional, Bouchoux, Guillaume, additional, Puget, Stéphanie, additional, Grill, Jacques, additional, and Carpentier, Alexandre, additional
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- 2020
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53. Brain abscess in children, a two-centre audit: outcomes and controversies
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Gilard, Vianney, primary, Beccaria, Kévin, additional, Hartley, John C, additional, Blanot, Stéphane, additional, Marqué, Sophie, additional, Bourgeois, Marie, additional, Puget, Stephanie, additional, Thompson, Dominic, additional, Zerah, Michel, additional, and Tisdall, Martin, additional
- Published
- 2019
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54. A malignant choroid plexus tumour with prevailing immature blastematous elements.
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Tauziède‐Espariat, Arnault, Pagès, Mélanie, Masliah‐Planchon, Julien, Bourdeaut, Franck, Doz, François, Beccaria, Kévin, Boddaert, Nathalie, Hasty, Lauren, Lechapt, Emmanuèle, Thomas, Christian, Paulus, Werner, Varlet, Pascale, and Hasselblatt, Martin
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CHOROID plexus ,TUMORS - Abstract
Keywords: blastematous; choroid plexus tumour; DNA methylation profiling; mesenchymal EN blastematous choroid plexus tumour DNA methylation profiling mesenchymal 1 3 3 02/03/22 20220215 NES 220215 INTRODUCTION Choroid plexus tumours are intraventricular neoplasms derived from the choroid plexus epithelium. (F) Black scale bars represent 500 m for panel (B) and 50 m for panels (C)-(E) gl DNA-methylation profiling (Illumina Methylation EPIC BeadChip) using the Heidelberg central nervous system (CNS) tumour classifier3 showed the case to be a "choroid plexus tumour, subclass paediatric B" (calibrated score 0.99), and the similarity with this molecular subgroup was further confirmed by t-SNE analysis (Figure 1F). The high similarity of the DNA methylation profile with choroid plexus tumours of the molecular subclass paediatric B is characteristic for malignant choroid plexus tumours and may suggest that the tumour secondarily acquired blastematous features. [Extracted from the article]
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- 2022
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55. Brain abscess in children, a two-centre audit: outcomes and controversies.
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Gilard, Vianney, Beccaria, Kévin, Hartley, John C., Blanot, Stéphane, Marqué, Sophie, Bourgeois, Marie, Puget, Stephanie, Thompson, Dominic, Zerah, Michel, and Tisdall, Martin
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BRAIN abscess ,SURGICAL drainage ,INFANTS ,MENINGITIS ,STREPTOCOCCAL disease diagnosis ,ANTIBIOTICS ,OTOLARYNGOLOGY diagnosis ,AUDITING ,RESEARCH ,RESEARCH methodology ,RETROSPECTIVE studies ,EVALUATION research ,MEDICAL cooperation ,TREATMENT effectiveness ,BACTERIAL meningitis ,STAPHYLOCOCCAL diseases ,COMPARATIVE studies ,QUESTIONNAIRES ,OTOLARYNGOLOGY ,DISEASE complications - Abstract
Objective: The aim of this study was to better characterise clinical presentation, management and outcome in infants and children with brain abscess.Methods: The authors conducted a retrospective, multicentre study in two national reference centres over a 25-year period (1992-2017). During this period, 116 children and 28 infants (age <1 year) with brain abscess were treated.Results: The median age at diagnosis was 101.5 (range: 13-213) months in children and 1 (0-11) month in infants. Significant differences were observed between children and infants. The most common predisposing factor was meningitis in infants (64% of cases vs 3% in children), while it was otolaryngology-related infection in children (31% of cases vs 3.6% in infants). Infants presented more frequently with fever and meningism compared with children. 115 patients were treated with aspiration and 11 with excision. Reoperation was required in 29 children vs 1 infant. The overall mortality rate was 4% (3.4% for children, 7.1% for infants). At 3-month follow-up, the outcome was favourable in 86% of children vs in 68% of infants.Conclusion: There is a clear difference between children and infants with brain abscess in terms of predisposing factors, causative organisms and outcome. Despite surgical drainage and directed antibiotic therapy, 25% of patients with brain abscess require reoperation. Mortality is improved compared with historical series; however, long-term morbidity is significant particularly in the infant population. [ABSTRACT FROM AUTHOR]- Published
- 2020
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56. Kyste de la fosse postérieure chez l’enfant : intérêt de l’évaluation posturographique et socio-émotionnelle
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Lebert, Angélique, Vergilino-Perez, Dorine, Cuny, Marie-Laure, Prodhomme, Julie, Puget, Stéphanie, Beccaria, Kevin, and Chaby, Laurence
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- 2019
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57. New in vivo avatars of diffuse intrinsic pontine gliomas (DIPG) from stereotactic biopsies performed at diagnosis
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Plessier, Alexandre, primary, Le Dret, Ludivine, additional, Varlet, Pascale, additional, Beccaria, Kévin, additional, Lacombe, Joëlle, additional, Mériaux, Sébastien, additional, Geffroy, Françoise, additional, Fiette, Laurence, additional, Flamant, Patricia, additional, Chrétien, Fabrice, additional, Blauwblomme, Thomas, additional, Puget, Stéphanie, additional, Grill, Jacques, additional, Debily, Marie-Anne, additional, and Castel, David, additional
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- 2017
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58. Interaction entre émotion et contrôle postural chez des enfants et des adolescents porteurs d’un kyste de la fosse postérieure
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Lebert, Angélique, Chaby, Laurence, Cuny, Marie-Laure, Puget, Stéphanie, Beccaria, Kevin, and Vergilino-Perez, Dorine
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- 2018
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59. HG-55DEVELOPMENT OF IN VIVO MODELS OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) FROM STEREOTACTIC BIOPSIES PERFORMED AT DIAGNOSIS
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Plessier, Alexandre, primary, Le Dret, Ludivine, additional, Fiette, Laurence, additional, Mériaux, Sébastien, additional, Beccaria, Kévin, additional, Varlet, Pascale, additional, Puget, Stéphanie, additional, Grill, Jacques, additional, Debily, Marie-Anne, additional, and Castel, David, additional
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- 2016
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60. Highlights of Children with Cancer UK’s Workshop on Drug Delivery in Paediatric Brain Tumours
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Nailor, Audrey, primary, Walker, David A, additional, Jacques, Thomas S, additional, Warren, Kathy E, additional, Brem, Henry, additional, Kearns, Pamela R, additional, Greenwood, John, additional, Penny, Jeffrey I, additional, Pilkington, Geoffrey J, additional, Carcaboso, Angel M, additional, Fleischhack, Gudrun, additional, Macarthur, Donald, additional, Slavc, Irene, additional, Meijer, Lisethe, additional, Gill, Steven, additional, Lowis, Stephen, additional, van Vuurden, Dannis G, additional, Pearl, Monica S, additional, Clifford, Steven C, additional, Morrissy, A Sorana, additional, Ivanov, Delyan P, additional, Beccaria, Kévin, additional, Gilbertson, Richard J, additional, Straathof, Karin, additional, Green, Jordan J, additional, Smith, Stuart, additional, Rahman, Ruman, additional, and Kilday, John-Paul, additional
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- 2016
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61. Les chordomes pédiatriques : à propos d'une série de 31 cas et revue de la littérature
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Beccaria, Kévin, Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), and Stéphanie Puget
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[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Pédiatrique ,Chordome ,[SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery ,Protonthérapie ,[SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery ,Base du crâne ,Rachis ,Tumeur ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Introduction : les chordomes sont des tumeurs malignes rares de la base du crâne et du rachis touchant les enfants dans moins de 5% des cas. Leur pronostic dépend surtout des récidives locales. Le traitement est basé sur l’exérèse chirurgicale maximale associée à une radiothérapie, idéalement aux protons. Matériels et méthodes : 31 patients âgés de moins de 18 ans traités pour un chordome à l’Hôpital Necker et à l’Hôpital Lariboisière entre 1966 et 2012 ont été inclus dans ce travail. Les données cliniques, radiologiques, anatomopathologiques, et thérapeutiques ont été recueillies. Elles ont été comparées aux données d’une revue de la littérature comprenant près de 250 cas de chordomes pédiatriques. Résultats : les chordomes intracrâniens et de la charnière crânio-cervicale étaient majoritaires dans notre série (26/31). Le taux d’exérèse complète était de 19.4%. Vingt-neuf enfants ont été irradiés et quatre ont reçu de la chimiothérapie. Lors du dernier contrôle, 25.8% et 37.8% des patients étaient en rémission complète ou en maladie stable. La survie sans progression et la survie globale étaient de 54.3% et 63% à 15 ans. Les facteurs de meilleur pronostic étaient l’exérèse complète, le type histologique classique, l’irradiation et la localisation au clivus. Les enfants de moins de 5 ans ont présenté des formes plus agressives de la maladie. Ces données sont concordantes avec les données de la littérature. Conclusion : la prise en charge des chordomes de l’enfant est pluridisciplinaire et doit être agressive pour obtenir des résultats satisfaisants. Elle repose sur la chirurgie et la protonthérapie ; la place des thérapies ciblées sera à réévaluer à l’avenir.
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- 2013
62. Liste des auteurs
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Adamsbaum, Catherine, Akkari, Samia, Arama, Emmanuel, Aschero, Audrey, Aubart, Mélodie, Avni, Fred E, Beccaria, Kevin, Bertrand, Margaux, Bessou, Pierre, Blondiaux, Éléonore, Blouet, Marie, Boddaert, Nathalie, Boumerzoug, Meriem, Boutry, Nathalie, Brisse, Hervé, Cardoen, Liesbeth, Chateil, Jean-François, Colavolpe, Nathalie, Dabadie, Alexia, Dangouloff-Ros, Volodia, Delmas, Jean, Desvignes, Catherine, le Pointe, Hubert Ducou, Durand, Chantal, El Fayoumi, Mohamed, Elmaleh-Bergès, Monique, Falip, Céline, Ferey, Solène, Fievet, Adèle, Franchi-Abella, Stéphanie, Garel, Catherine, Grangette, Ève, Grévent, David, Habre, Céline, Hassani, Adnan, Lahoche, Annie, Le Cam, Solène, Lérisson, Héloïse, Levy, Raphaël, Mathiot, Anne, Morel, Baptiste, Nicolas, Nayla, Ouerd, Linda, Petit, Philippe, Pico, Harmony, Priso, Réne-Hilaire, Rapilat, Daniela, Rocher, Laurence, Roux, Charles-Joris, Seiler, Charlotte, Taveau, Catherine Sembély, Suffee, Cécile, Perre, Saskia Vande, Verpillat, Pauline, and Vivier, Pierre-Hugues
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- 2022
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63. Les auteurs
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Roche, Pierre-Hugues, Proust, François, Emery, Évelyne, Vassal, François, Almairac, Fabien, Amelot, Aymeric, Anthérieu, Pierre, Barrey, Cédric, Beccaria, Kevin, Beuriat, Pierre-Aurélien, Boetto, Julien, Buffenoir, Kevin, Caire, François, Cebula, Hélène, Colnat-Coulbois, Sophie, Di Rocco, Federico, Gaberel, Thomas, Gilard, Vianney, Goutagny, Stéphane, Graillon, Thomas, Kleiber, Jean-Charles, Klein, Olivier, Magro, Elsa, Pallud, Johan, Rigoard, Philippe, de Saint-Denis, Timothée, Seizeur, Romuald, Simon, Émile, Tetard, Marie-Charlotte, Thines, Laurent, Todeschi, Julien, Troude, Lucas, Vignes, Jean-Rodolphe, and Zemmoura, Ilyess
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- 2022
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64. Paediatric Chordomas
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Beccaria, Kévin, primary, Sainte-Rose, Christian, additional, Zerah, Michel, additional, and Puget, Stéphanie, additional
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- 2015
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65. 5th International Symposium on Focused Ultrasound: North Bethesda, MD, USA. 28 August- 1 September 2016
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Zaaroor, Menashe, Sinai, Alon, Goldsher, Dorit, Eran, Ayelet, Nassar, Maria, Schlesinger, Ilana, Parker, Jonathon, Ravikumar, Vinod, Ghanouni, Pejman, Stein, Sherman, Halpern, Casey, Krishna, Vibhor, Hargrove, Amelia, Agrawal, Punit, Changizi, Barbara, Bourekas, Eric, Knopp, Michael, Rezai, Ali, Mead, Brian, Kim, Namho, Mastorakos, Panagiotis, Suk, Jung Soo, Miller, Wilson, Klibanov, Alexander, Hanes, Justin, Price, Richard, Wang, Shutao, Olumolade, Oluyemi, Kugelman, Tara, Jackson-Lewis, Vernice, Karakatsani, Maria Eleni (Marilena), Han, Yang, Przedborski, Serge, Konofagou, Elisa, Hynynen, Kullervo, Aubert, Isabelle, Leinenga, Gerhard, Nisbet, Rebecca, Hatch, Robert, Van der Jeugd, Anneke, Evans, Harrison, Götz, Jürgen, Van der Jeugd, Ann, Fishman, Paul, Yarowsky, Paul, Frenkel, Victor, Wei-Bin, Shen, Nguyen, Ben, Sanchez, Carlos Sierra, Acosta, Camilo, Chen, Cherry, Wu, Shih-Ying, Aryal, Muna, Papademetriou, Iason T., Zhang, Yong-Zhi, Power, Chanikarn, McDannold, Nathan, Porter, Tyrone, Kovacs, Zsofia, Kim, Saejeong, Jikaria, Neekita, Qureshi, Farhan, Bresler, Michele, Frank, Joseph, Odéen, Henrik, Chiou, George, Snell, John, Todd, Nick, Madore, Bruno, Parker, Dennis, Pauly, Kim Butts, Marx, Mike, Jonathan, Sumeeth, Grissom, William, Arvanitis, Costas, Clement, Gregory, de Bever, Joshua, Payne, Allison, Christensen, Douglas, Maimbourg, Guillaume, Santin, Mathieu David, Houdouin, Alexandre, Lehericy, Stéphane, Tanter, Mickael, Aubry, Jean Francois, Federau, Christian, Werner, Beat, Paeng, Dong-Guk, Xu, Zhiyuan, Quigg, Anders, Eames, Matt, Jin, Changzhu, Everstine, Ashli, Sheehan, Jason, Lopes, M. Beatriz, Kassell, Neal, Drake, James, Price, Karl, Lustgarten, Lior, Sin, Vivian, Mougenot, Charles, Donner, Elizabeth, Tam, Emily, Hodaie, Mojgan, Waspe, Adam, Looi, Thomas, Pichardo, Samuel, Lee, Wonhye, Chung, Yong An, Jung, Yujin, Song, In-Uk, Yoo, Seung-Schik, Kim, Hyun-Chul, Lee, Jong-Hwan, Caskey, Charles, Zinke, Wolf, Cosman, Josh, Shuman, Jillian, Schall, Jeffrey, Aurup, Christian, Chen, Hong, Kamimura, Hermes, Carneiro, Antonio, Sun, Tao, Nazai, Navid, Patz, Sam, Livingstone, Margaret, Mainprize, Todd, Huang, Yuexi, Alkins, Ryan, Chapman, Martin, Perry, James, Lipsman, Nir, Bethune, Allison, Sahgal, Arjun, Trudeau, Maureen, Liu, Hao-Li, Hsu, Po-Hung, Wei, Kuo-Chen, Sutton, Jonathan, Alexander, Phillip, Miller, Eric, Kobus, Thiele, Carpentier, Alexandre, Canney, Michael, Vignot, Alexandre, Beccaria, Kevin, Leclercq, Delphine, Lafon, Cyril, Chapelon, Jean Yves, Hoang-Xuan, Khe, Delattre, Jean-Yves, Idbaih, Ahmed, Moore, David, Xu, Alexis, Schmitt, Paul, Foley, Jessica, Sukovich, Jonathan, Cain, Charles, Pandey, Aditya, Chaudhary, Neeraj, Camelo-Piragua, Sandra, Allen, Steven, Cannata, Jon, Teofilovic, Dejan, Bertolina, Jim, Hall, Timothy, Xu, Zhen, Grondin, Julien, Ferrera, Vincent, ter Haar, Gail, Mouratidis, Petros, Repasky, Elizabeth, Timbie, Kelsie, Badr, Lena, Campbell, Benjamin, McMichael, John, Buckner, Andrew, Prince, Jessica, Stevens, Aaron, Bullock, Timothy, Skalina, Karin, Guha, Chandan, Orsi, Franco, Bonomo, Guido, Vigna, Paolo Della, Mauri, Giovanni, Varano, Gianluca, Schade, George, Wang, Yak-Nam, Pillarisetty, Venu, Hwang, Joo Ha, Khokhlova, Vera, Bailey, Michael, Khokhlova, Tatiana, Sinilshchikov, Ilya, Yuldashev, Petr, Andriyakhina, Yulia, Kreider, Wayne, Maxwell, Adam, Sapozhnikov, Oleg, Partanen, Ari, Lundt, Jonathan, Preusser, Tobias, Haase, Sabrina, Bezzi, Mario, Jenne, Jürgen, Langø, Thomas, Midiri, Massimo, Mueller, Michael, Sat, Giora, Tanner, Christine, Zangos, Stephan, Guenther, Matthias, Melzer, Andreas, Menciassi, Arianna, Tognarelli, Selene, Cafarelli, Andrea, Diodato, Alessandro, Ciuti, Gastone, Rothluebbers, Sven, Schwaab, Julia, Strehlow, Jan, Mihcin, Senay, Tretbar, Steffen, Payen, Thomas, Palermo, Carmine, Sastra, Steve, Olive, Kenneth, Adams, Matthew, Salgaonkar, Vasant, Scott, Serena, Sommer, Graham, Diederich, Chris, Vidal-Jove, Joan, Perich, Eloi, Ruiz, Antonio, Velat, Manuela, Melodelima, David, Dupre, Aurelien, Vincenot, Jeremy, Yao, Chen, Perol, David, Rivoire, Michel, Tucci, Samantha, Mahakian, Lisa, Fite, Brett, Ingham, Elizabeth, Tam, Sarah, Hwang, Chang-il, Tuveson, David, Ferrara, Katherine, Scionti, Stephen, Chen, Lili, Cvetkovic, Dusica, Chen, Xiaoming, Gupta, Roohi, Wang, Bin, Ma, Charlie, Bader, Kenneth, Haworth, Kevin, Holland, Christy, Sanghvi, Narendra, Carlson, Roy, Chen, Wohsing, Chaussy, Christian, Thueroff, Stefan, Cesana, Claudio, Bellorofonte, Carlo, Wang, Qingguo, Wang, Han, Wang, Shengping, Zhang, Junhai, Bazzocchi, Alberto, Napoli, Alessandro, Staruch, Robert, Bing, Chenchen, Shaikh, Sumbul, Nofiele, Joris, Szczepanski, Debra, Staruch, Michelle Wodzak, Williams, Noelle, Laetsch, Theodore, Chopra, Rajiv, Rosenberg, Jarrett, Bitton, Rachelle, LeBlang, Suzanne, Meyer, Joshua, Hurwitz, Mark, Yarmolenko, Pavel, Celik, Haydar, Eranki, Avinash, Beskin, Viktoriya, Santos, Domiciano, Patel, Janish, Oetgen, Matthew, Kim, AeRang, Kim, Peter, Sharma, Karun, Chisholm, Alexander, Aleman, Dionne, Scipione, Roberto, Temple, Michael, Amaral, Joao Guilherme, Endre, Ruby, Lamberti-Pasculli, Maria, de Ruiter, Joost, Campbell, Fiona, Stimec, Jennifer, Gupta, Samit, Singh, Manoj, Hopyan, Sevan, Czarnota, Gregory, Brenin, David, Rochman, Carrie, Kovatcheva, Roussanka, Vlahov, Jordan, Zaletel, Katja, Stoinov, Julian, Bucknor, Matthew, Rieke, Viola, Shim, Jenny, Koral, Korgun, Lang, Brian, Wong, Carlos, Lam, Heather, Shinkov, Alexander, Hu, Jim, Zhang, Xi, Macoskey, Jonathan, Ives, Kimberly, Owens, Gabe, Gurm, Hitinder, Shi, Jiaqi, Pizzuto, Matthew, Dillon, Christopher, Christofferson, Ivy, Hilas, Elaine, Shea, Jill, Greillier, Paul, Ankou, Bénédicte, Bessière, Francis, Zorgani, Ali, Pioche, Mathieu, Kwiecinski, Wojciech, Magat, Julie, Melot-Dusseau, Sandrine, Lacoste, Romain, Quesson, Bruno, Pernot, Mathieu, Catheline, Stefan, Chevalier, Philippe, Marquet, Fabrice, Bour, Pierre, Vaillant, Fanny, Amraoui, Sana, Dubois, Rémi, Ritter, Philippe, Haïssaguerre, Michel, Hocini, Mélèze, Bernus, Olivier, Tebebi, Pamela, Burks, Scott, Milo, Blerta, Gertner, Michael, Zhang, Jimin, Wong, Andrew, Liu, Yu, Kheirolomoom, Azadeh, Seo, Jai, Watson, Katherine, Zhang, Hua, Foiret, Josquin, Borowsky, Alexander, Xu, Doudou, Thanou, Maya, Centelles, Miguell, Wright, Mike, Amrahli, Maral, So, Po-Wah, Gedroyc, Wladyslaw, Kneepkens, Esther, Heijman, Edwin, Keupp, Jochen, Weiss, Steffen, Nicolay, Klaas, Grüll, Holger, Nagle, Matthew, Nikolaeva, Anastasia V., Terzi, Marina E., Tsysar, Sergey A., Cunitz, Bryan, Mourad, Pierre, Downs, Matthew, Yang, Georgiana, Wang, Qi, Chen, Johnny, Farry, Justin, Dixon, Adam, Du, Zhongmin, Dhanaliwala, Ali, Hossack, John, Ranjan, Ashish, Maples, Danny, Wardlow, Rachel, Malayer, Jerry, Ramachandran, Akhilesh, Namba, Hirofumi, Kawasaki, Motohiro, Izumi, Masashi, Kiyasu, Katsuhito, Takemasa, Ryuichi, Ikeuchi, Masahiko, Ushida, Takahiro, Crake, Calum, Kothapalli, Satya V. V. N., Leighton, Wan, Wang, Zhaorui, Gach, H. Michael, Straube, William, Altman, Michael, Kim, Young-sun, Lim, Hyo Keun, Rhim, Hyunchul, van Breugel, Johanna, Braat, Manon, Moonen, Chrit, van den Bosch, Maurice, Ries, Mario, Marrocchio, Cristina, Dababou, Susan, Lee, Jae Young, Chung, Hyun Hoon, Kang, Soo Yeon, Kang, Kook Jin, Son, Keon Ho, Zhang, Dandan, Plata, Juan, Jones, Peter, Pascal-Tenorio, Aurea, Bouley, Donna, Bond, Aaron, Dallapiazza, Robert, Huss, Diane, Warren, Amy, Sperling, Scott, Gwinn, Ryder, Shah, Binit, Elias, W. Jeff, Curley, Colleen, Zhang, Ying, Negron, Karina, Abounader, Roger, Samiotaki, Gesthimani, Tu, Tsang-Wei, Papadakis, Georgios, Hammoud, Dima, Silvestrini, Matthew, Wolfram, Frank, Güllmar, Daniel, Reichenbach, Juergen, Hofmann, Denis, Böttcher, Joachim, Schubert, Harald, Lesser, Thomas G., Almquist, Scott, Camarena, Francisco, Jiménez-Gambín, Sergio, Jiménez, Noé, Chang, Jin Woo, Chaplin, Vandiver, Griesenauer, Rebekah, Miga, Michael, Ellens, Nicholas, Airan, Raag, Quinones-Hinojosa, Alfredo, Farahani, Keyvan, Feng, Xue, Fielden, Samuel, Zhao, Li, Wintermark, Max, Meyer, Craig, Guo, Sijia, Lu, Xin, Zhuo, Jiachen, Xu, Su, Gullapalli, Rao, Gandhi, Dheeraj, Brokman, Omer, Baek, Hongchae, Kim, Hyungmin, Leung, Steven, Webb, Taylor, Vykhodtseva, Natalia, Nguyen, Thai-Son, Park, Chang Kyu, Park, Sang Man, Jung, Na Young, Kim, Min Soo, Chang, Won Seok, Jung, Hyun Ho, Plaksin, Michael, Weissler, Yoni, Shoham, Shy, Kimmel, Eitan, Rosnitskiy, Pavel B., Krupa, Steve, Hazan, Eilon, Naor, Omer, Levy, Yoav, Maimon, Noam, Brosh, Inbar, Kahn, Itamar, Cahill, Jessica, Colas, Elodie Constanciel, Wydra, Adrian, Maev, Roman, Aly, Amirah, Sesenoglu-Laird, Ozge, Padegimas, Linas, Cooper, Mark, Waszczak, Barbara, Tehrani, Seruz, Slingluff, Craig, Larner, James, Andarawewa, Kumari, Ozhinsky, Eugene, Shah, Rutwik, Krug, Roland, Deckers, Roel, Linn, Sabine, Suelmann, Britt, Witkamp, Arjen, Vaessen, Paul, van Diest, Paul, Bartels, Lambertus W., Bos, Clemens, Borys, Nicolas, Storm, Gert, Van der Wall, Elsken, Farr, Navid, Alnazeer, Moez, Katti, Prateek, Wood, Bradford, Farrer, Alexis, Ferrer, Cyril, de Senneville, Baudouin Denis, van Stralen, Marijn, Liu, Jingfei, Leach, J. Kent, Zidowitz, Stephan, Lee, Hsin-Lun, Hsu, Fang-Chi, Kuo, Chia-Chun, Jeng, Shiu-Chen, Chen, Tung-Ho, Yang, Nai-Yi, Chiou, Jeng-Fong, Kao, Yi-tzu, Pan, Chia-Hsin, Wu, Jing-Fu, Tsai, Yi-Chieh, Johnson, Sara, Li, Dawei, He, Ye, Karakitsios, Ioannis, Schwenke, Michael, Demedts, Daniel, Xiao, Xu, Cavin, Ian, Minalga, Emilee, Merrill, Robb, Hadley, Rock, Ramaekers, Pascal, de Greef, Martijn, Shahriari, Kian, Parvizi, Mohammad Hossein, Asadnia, Kiana, Chamanara, Marzieh, Kamrava, Seyed Kamran, Chabok, Hamid Reza, Stein, Ruben, Muller, Sébastien, Tan, Jeremy, Zachiu, Cornel, Erasmus, Hans-Peter, Van Arsdell, Glen, Benson, Lee, Jang, Kee W., Angstadt, Mary, Lewis, Bobbi, McLean, Hailey, Hoogenboom, Martijn, Eikelenboom, Dylan, den Brok, Martijn, Wesseling, Pieter, Heerschap, Arend, Fütterer, Jurgen, Adema, Gosse, Wang, Kevin, Zhong, Pei, Joy, Joyce, McLeod, Helen, Kim, Harry, Lewis, Matthew, Ozilgen, Arda, Zahos, Peter, Coughlin, Dezba, Tang, Xinyan, Lotz, Jeff, Jedruszczuk, Kathleen, Gulati, Amitabh, Solomon, Stephen, Kaye, Elena, Mugler, John, Barbato, Gaetano, Scoarughi, Gian Luca, Corso, Cristiano, Gorgone, Alessandro, Migliore, Ilaria Giuseppina, Larrabee, Zachary, Hananel, Arik, Aubry, Jean-Francois, Negussie, Ayele, Wilson, Emmanuel, Seifabadi, Reza, Moon, Hyungwon, Kang, Jeeun, Sim, Changbeom, Chang, Jin Ho, Kim, Hyuncheol, Lee, Hak Jong, Sasaki, Noboru, Takiguchi, Mitsuyoshi, Sebeke, Lukas, Luo, Xi, de Jager, Bram, Heemels, Maurice, Abraham, Christopher, Curiel, Laura, Berriet, Rémi, Janát-Amsbury, Margit, Corea, Joseph, Ye, Patrick Peiyong, Arias, Ana Clauda, Lustig, Micheal, and Svedin, Bryant
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- 2016
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66. Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours
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Nailor, Audrey, Walker, David A., Jacques, Thomas S., Warren, Kathy E., Brem, Henry, Kearns, Pamela R., Greenwood, John, Penny, Jeffrey I., Pilkington, Geoffrey J., Carcaboso, Angel M., Fleischhack, Gudrun, Macarthur, Donald, Slavc, Irene, Meijer, Lisethe, Gill, Steven, Lowis, Stephen, van Vuurden, Dannis G., Pearl, Monica S., Clifford, Steven C., Morrissy, A. Sorana, Ivanov, Delyan P., Beccaria, Kévin, Gilbertson, Richard J., Straathof, Karin, Green, Jordan J., Smith, Stuart, Rahman, Ruman, Kilday, John-Paul, Nailor, Audrey, Walker, David A., Jacques, Thomas S., Warren, Kathy E., Brem, Henry, Kearns, Pamela R., Greenwood, John, Penny, Jeffrey I., Pilkington, Geoffrey J., Carcaboso, Angel M., Fleischhack, Gudrun, Macarthur, Donald, Slavc, Irene, Meijer, Lisethe, Gill, Steven, Lowis, Stephen, van Vuurden, Dannis G., Pearl, Monica S., Clifford, Steven C., Morrissy, A. Sorana, Ivanov, Delyan P., Beccaria, Kévin, Gilbertson, Richard J., Straathof, Karin, Green, Jordan J., Smith, Stuart, Rahman, Ruman, and Kilday, John-Paul
- Abstract
The first Workshop on Drug Delivery in Paediatric Brain Tumours was hosted in London by the charity Children with Cancer UK. The goals of the workshop were to break down the barriers to treating central nervous system (CNS) tumours in children, leading to new collaborations and further innovations in this under-represented and emotive field. These barriers include the physical delivery challenges presented by the blood–brain barrier, the underpinning reasons for the intractability of CNS cancers, and the practical difficulties of delivering cancer treatment to the brains of children. Novel techniques for overcoming these problems were discussed, new models brought forth, and experiences compared.
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67. Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours
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Nailor, Audrey, Walker, David A., Jacques, Thomas S., Warren, Kathy E., Brem, Henry, Kearns, Pamela R., Greenwood, John, Penny, Jeffrey I., Pilkington, Geoffrey J., Carcaboso, Angel M., Fleischhack, Gudrun, Macarthur, Donald, Slavc, Irene, Meijer, Lisethe, Gill, Steven, Lowis, Stephen, van Vuurden, Dannis G., Pearl, Monica S., Clifford, Steven C., Morrissy, A. Sorana, Ivanov, Delyan P., Beccaria, Kévin, Gilbertson, Richard J., Straathof, Karin, Green, Jordan J., Smith, Stuart, Rahman, Ruman, Kilday, John-Paul, Nailor, Audrey, Walker, David A., Jacques, Thomas S., Warren, Kathy E., Brem, Henry, Kearns, Pamela R., Greenwood, John, Penny, Jeffrey I., Pilkington, Geoffrey J., Carcaboso, Angel M., Fleischhack, Gudrun, Macarthur, Donald, Slavc, Irene, Meijer, Lisethe, Gill, Steven, Lowis, Stephen, van Vuurden, Dannis G., Pearl, Monica S., Clifford, Steven C., Morrissy, A. Sorana, Ivanov, Delyan P., Beccaria, Kévin, Gilbertson, Richard J., Straathof, Karin, Green, Jordan J., Smith, Stuart, Rahman, Ruman, and Kilday, John-Paul
- Abstract
The first Workshop on Drug Delivery in Paediatric Brain Tumours was hosted in London by the charity Children with Cancer UK. The goals of the workshop were to break down the barriers to treating central nervous system (CNS) tumours in children, leading to new collaborations and further innovations in this under-represented and emotive field. These barriers include the physical delivery challenges presented by the blood–brain barrier, the underpinning reasons for the intractability of CNS cancers, and the practical difficulties of delivering cancer treatment to the brains of children. Novel techniques for overcoming these problems were discussed, new models brought forth, and experiences compared.
- Full Text
- View/download PDF
68. Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours
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Nailor, Audrey, Walker, David A., Jacques, Thomas S., Warren, Kathy E., Brem, Henry, Kearns, Pamela R., Greenwood, John, Penny, Jeffrey I., Pilkington, Geoffrey J., Carcaboso, Angel M., Fleischhack, Gudrun, Macarthur, Donald, Slavc, Irene, Meijer, Lisethe, Gill, Steven, Lowis, Stephen, van Vuurden, Dannis G., Pearl, Monica S., Clifford, Steven C., Morrissy, A. Sorana, Ivanov, Delyan P., Beccaria, Kévin, Gilbertson, Richard J., Straathof, Karin, Green, Jordan J., Smith, Stuart, Rahman, Ruman, Kilday, John-Paul, Nailor, Audrey, Walker, David A., Jacques, Thomas S., Warren, Kathy E., Brem, Henry, Kearns, Pamela R., Greenwood, John, Penny, Jeffrey I., Pilkington, Geoffrey J., Carcaboso, Angel M., Fleischhack, Gudrun, Macarthur, Donald, Slavc, Irene, Meijer, Lisethe, Gill, Steven, Lowis, Stephen, van Vuurden, Dannis G., Pearl, Monica S., Clifford, Steven C., Morrissy, A. Sorana, Ivanov, Delyan P., Beccaria, Kévin, Gilbertson, Richard J., Straathof, Karin, Green, Jordan J., Smith, Stuart, Rahman, Ruman, and Kilday, John-Paul
- Abstract
The first Workshop on Drug Delivery in Paediatric Brain Tumours was hosted in London by the charity Children with Cancer UK. The goals of the workshop were to break down the barriers to treating central nervous system (CNS) tumours in children, leading to new collaborations and further innovations in this under-represented and emotive field. These barriers include the physical delivery challenges presented by the blood–brain barrier, the underpinning reasons for the intractability of CNS cancers, and the practical difficulties of delivering cancer treatment to the brains of children. Novel techniques for overcoming these problems were discussed, new models brought forth, and experiences compared.
- Full Text
- View/download PDF
69. Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours
- Author
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Nailor, Audrey, Walker, David A., Jacques, Thomas S., Warren, Kathy E., Brem, Henry, Kearns, Pamela R., Greenwood, John, Penny, Jeffrey I., Pilkington, Geoffrey J., Carcaboso, Angel M., Fleischhack, Gudrun, Macarthur, Donald, Slavc, Irene, Meijer, Lisethe, Gill, Steven, Lowis, Stephen, van Vuurden, Dannis G., Pearl, Monica S., Clifford, Steven C., Morrissy, A. Sorana, Ivanov, Delyan P., Beccaria, Kévin, Gilbertson, Richard J., Straathof, Karin, Green, Jordan J., Smith, Stuart, Rahman, Ruman, Kilday, John-Paul, Nailor, Audrey, Walker, David A., Jacques, Thomas S., Warren, Kathy E., Brem, Henry, Kearns, Pamela R., Greenwood, John, Penny, Jeffrey I., Pilkington, Geoffrey J., Carcaboso, Angel M., Fleischhack, Gudrun, Macarthur, Donald, Slavc, Irene, Meijer, Lisethe, Gill, Steven, Lowis, Stephen, van Vuurden, Dannis G., Pearl, Monica S., Clifford, Steven C., Morrissy, A. Sorana, Ivanov, Delyan P., Beccaria, Kévin, Gilbertson, Richard J., Straathof, Karin, Green, Jordan J., Smith, Stuart, Rahman, Ruman, and Kilday, John-Paul
- Abstract
The first Workshop on Drug Delivery in Paediatric Brain Tumours was hosted in London by the charity Children with Cancer UK. The goals of the workshop were to break down the barriers to treating central nervous system (CNS) tumours in children, leading to new collaborations and further innovations in this under-represented and emotive field. These barriers include the physical delivery challenges presented by the blood–brain barrier, the underpinning reasons for the intractability of CNS cancers, and the practical difficulties of delivering cancer treatment to the brains of children. Novel techniques for overcoming these problems were discussed, new models brought forth, and experiences compared.
- Full Text
- View/download PDF
70. Post-zygotic mosaicism of SMARCB1 variants in patients with rhabdoid tumors: a not so rare condition exposing to successive tumors.
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Thomson G, Filser M, Guerrini-Rousseau L, Tauziede-Espariat A, Bourneix C, Gauthier-Villars M, Simaga F, Beccaria K, Faure-Conter C, Maureille A, Zattara-Cannoni H, Andre N, Entz-Werle N, Brugieres L, Mansuy L, Denizeau P, Julia S, Ingster O, Lejeune S, Brahimi A, Coupier I, Bonadona V, Delattre O, Masliah-Planchon J, and Bourdeaut F
- Abstract
Background: Rhabdoid tumors (RT) are aggressive, rare tumors predominantly affecting young children, characterized by bi-allelic SMARCB1 gene inactivation. While most SMARCB1 alterations are acquired de novo, a third of cases exhibit germline alterations, defining Rhabdoid Tumors Predisposition Syndrome (RTPS1). With increased sensitivity of next-generation sequencing (NGS), mosaicisms in genes linked to genetic diseases are more detectable. This study focuses on exploring SMARCB1 germline alterations, notably mosaicism in blood samples of children with RT and in parents, using a custom NGS panel., Methods: A cohort of 280 children and 140 parents with germline analysis was studied. Germline DNA from 111 children with RT and 32 parents were re-analyzed with a custom NGS panel with 1,500X average depth targeting the SMARCB1 gene to identify intragenic variants not detected with conventional low-sensitivity methods. Follow-up data was obtained for 77 patients., Results: Nine previously undetected mosaicism cases were identified, totaling 17/280 patients with a mosaic variant (6.1%) in the cohort, with variant allele frequencies between 0.9% and 33%, thus highlighting the prior underestimation of its prevalence. Follow-up data showed that 4 out of 7 survivors with mosaic variants developed distinct novel tumors, two sharing SMARCB1 alterations with the initial tumor, emphasizing the potential clinical impact of SMARCB1 mosaicism., Conclusions: The hitherto underestimated rate of SMARCB1 mosaicism in RT underscores the need for optimized genetic counseling and oncological monitoring. The findings have significant medical implications, considering the dire prognosis of RT., (© The Author(s) 2024. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
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- 2024
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71. An integrative histopathological and epigenetic characterization of primary intracranial mesenchymal tumors, FET:CREB-fused broadening the spectrum of tumor entities in comparison with their soft tissue counterparts.
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Tauziède-Espariat A, Sievers P, Larousserie F, Benzakoun J, Guillemot D, Pierron G, Duchesne M, Uro-Coste E, Roux A, Vasiljevic A, Fenouil T, Meyronet D, Mokhtari K, Polivka M, Rousseau A, Bost-Bezeaud F, Akoury S, Pallud J, Benevello C, Hasty L, Gareton A, Lechapt E, Chrétien F, Blauwblomme T, Beccaria K, Puget S, Sahm F, and Varlet P
- Subjects
- Epigenesis, Genetic, Gene Fusion, Humans, RNA-Binding Protein EWS genetics, Brain Neoplasms genetics, Brain Neoplasms pathology, Histiocytoma, Malignant Fibrous genetics
- Abstract
FET:CREB fusions have been described in a variety of tumors from various phenotypes. Recently, these fusion transcripts were reported in intracranial tumors, variably named intracranial mesenchymal myxoid tumors or angiomatoid fibrous histiocytomas. Controversy remains concerning the terminology for these tumors. Here, we report 11 cases of central nervous system mesenchymal tumors with proven FET:CREB fusion. Most DNA methylation profiles were not classifiable using the Heidelberg Brain Tumor or Sarcoma Classifier (v11b4/v12.2). However, by using unsupervised t-SNE and hierarchical clustering analyses, six of the cases constituted a distinct cluster. The remaining four tumors showed no obvious relation to any of the other referenced classes but were close to the clusters of extra-CNS angiomatoid fibrous histiocytomas (n = 1), clear cell sarcomas (n = 1), or solitary fibrous tumors (n = 2). Our findings confirm that intracranial FET:CREB-fused tumors do not represent a single molecular tumor entity, although most samples clustered close to each other, indicating the existence of a distinct epigenetic group that could potentially be partially masked by the low number of cases included. Further analyses are needed to characterize intracranial FET:CREB fused-defined tumors in more detail., (© 2021 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.)
- Published
- 2022
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72. Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions.
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Tauziède-Espariat A, Siegfried A, Nicaise Y, Kergrohen T, Sievers P, Vasiljevic A, Roux A, Dezamis E, Benevello C, Machet MC, Michalak S, Puiseux C, Llamas-Gutierrez F, Leblond P, Bourdeaut F, Grill J, Dufour C, Guerrini-Rousseau L, Abbou S, Dangouloff-Ros V, Boddaert N, Saffroy R, Hasty L, Wahler E, Pagès M, Andreiuolo F, Lechapt E, Chrétien F, Blauwblomme T, Beccaria K, Pallud J, Puget S, Uro-Coste E, and Varlet P
- Subjects
- Adolescent, Adult, Child, Child, Preschool, DNA Methylation genetics, Ependymoma classification, Ependymoma metabolism, Ependymoma pathology, Female, Gene Fusion genetics, Genotype, Glial Fibrillary Acidic Protein metabolism, Humans, Infant, Male, NF-kappa B metabolism, Neural Cell Adhesion Molecule L1 metabolism, Nuclear Receptor Coactivator 1 genetics, Nuclear Receptor Coactivator 2 genetics, Phenotype, Supratentorial Neoplasms classification, Supratentorial Neoplasms metabolism, Supratentorial Neoplasms pathology, Trans-Activators genetics, Transcription Factor RelA genetics, Tumor Suppressor Proteins genetics, Young Adult, Ependymoma genetics, Proteins genetics, Supratentorial Neoplasms genetics
- Abstract
The cIMPACT-NOW Update 7 has replaced the WHO nosology of "ependymoma, RELA fusion positive" by "Supratentorial-ependymoma, C11orf95-fusion positive". This modification reinforces the idea that supratentorial-ependymomas exhibiting fusion that implicates the C11orf95 (now called ZFTA) gene with or without the RELA gene, represent the same histomolecular entity. A hot off the press molecular study has identified distinct clusters of the DNA methylation class of ZFTA fusion-positive tumors. Interestingly, clusters 2 and 4 comprised tumors of different morphologies, with various ZFTA fusions without involvement of RELA. In this paper, we present a detailed series of thirteen cases of non-RELA ZFTA-fused supratentorial tumors with extensive clinical, radiological, histopathological, immunohistochemical, genetic and epigenetic (DNA methylation profiling) characterization. Contrary to the age of onset and MRI aspects similar to RELA fusion-positive EPN, we noted significant histopathological heterogeneity (pleomorphic xanthoastrocytoma-like, astroblastoma-like, ependymoma-like, and even sarcoma-like patterns) in this cohort. Immunophenotypically, these NFκB immunonegative tumors expressed GFAP variably, but EMA constantly and L1CAM frequently. Different gene partners were fused with ZFTA: NCOA1/2, MAML2 and for the first time MN1. These tumors had epigenetic homologies within the DNA methylation class of ependymomas-RELA and were classified as satellite clusters 2 and 4. Cluster 2 (n = 9) corresponded to tumors with classic ependymal histological features (n = 4) but also had astroblastic features (n = 5). Various types of ZFTA fusions were associated with cluster 2, but as in the original report, ZFTA:MAML2 fusion was frequent. Cluster 4 was enriched with sarcoma-like tumors. Moreover, we reported a novel anatomy of three ZFTA:NCOA1/2 fusions with only 1 ZFTA zinc finger domain in the putative fusion protein, whereas all previously reported non-RELA ZFTA fusions have 4 ZFTA zinc fingers. All three cases presented a sarcoma-like morphology. This genotype/phenotype association requires further studies for confirmation. Our series is the first to extensively characterize this new subset of supratentorial ZFTA-fused ependymomas and highlights the usefulness of ZFTA FISH analysis to confirm the existence of a rearrangement without RELA abnormality., (© 2021. The Author(s).)
- Published
- 2021
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