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51. ECMO for COVID-19 patients in Europe and Israel

Author

Lorusso, Roberto, Combes, Alain, Lo Coco, Valeria, De Piero, Maria Elena, Belohlavek, Jan, Delnoij, Thijs, and van der Horst, Iwan

Subjects
Medical colleges, Health care industry
Abstract

Author(s): Roberto Lorusso [sup.1] [sup.2], Alain Combes [sup.3], Valeria Lo Coco [sup.1], Maria Elena De Piero [sup.1], Jan Belohlavek [sup.4], Thijs Delnoij, Iwan van der Horst, Dinis Reis Miranda, Marcel [...]

Published
2021
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53. NT-proBNP Response to Sacubitril/Valsartan in Hospitalized Heart Failure Patients With Reduced Ejection Fraction: TRANSITION Study

Author

Gniot, Jacek, Mozheiko, Maria, Lelonek, Malgorzata, Dominguez, Antonio Reyes, Horacek, Thomas, Garcia del Rio, Enrique, Kobalava, Zhanna, Mueller, Christian Eugen, Cavusoglu, Yuksel, Straburzynska-Migaj, Ewa, Slanina, Miroslav, vom Dahl, Juergen, Senni, Michele, Ryding, Alisdair, Moriarty, Andrew, Robles, Manuel Beltran, Villota, Julio Nunez, Quintana, Antonio Garcia, Nitschke, Thorsten, Garcia Pinilla, Jose Manuel, Bonet, Luis Almenar, Chaaban, Said, Filali zaatari, Samia, Spinar, Jindrich, Musial, Wlodzimierz, Abdelbaki, Khaled, Belohlavek, Jan, Fehske, Wolfgang, Bott, Michael Carlos, Hoegalmen, Geir, Leiro, Marisa Crespo, Ozcan, Ismail Turkay, Mullens, Wilfried, Kryza, Radim, Al-Ani, Riadh, Loboz-Grudzien, Krystyna, Ermoshkina, Lyudmila, Hojerova, Silvia, Fernandez, Alberto Alfredo, Spinarova, Lenka, Lapp, Harald, Bulut, Efraim, Almeida, Filipa, Vishnevsky, Alexander, Belicova, Margita, Pascual, Domingo, Witte, Klaus, Wong, Kenneth, Droogne, Walter, Delforge, Marc, Peterka, Martin, Olbrich, Hans-Georg, Carugo, Stefano, Nessler, Jadwiga, McGill, Thao Huynh, Huegl, Burkhard, Akin, Ibrahim, Moreira, Ilidio, Baglikov, Andrey, Thambyrajah, Jeetendra, Hayes, Chris, Barrionuevo, Marcelo Raul, Yigit, Zerrin, Kaya, Hakki, Klimsa, Zdenek, Radvan, Martin, Kadel, Christoph, Landmesser, Ulf, Di Tano, Giuseppe, Lisik, Malgorzata Buksinska, Fonseca, Candida, Oliveira, Luis, Marques, Irene, Santos, Luis Miguel, Lenner, Egon, Letavay, Peter, Bueno, Manuel Gomez, Mota, Paula, Wong, Aaron, Bailey, Kristian, Foley, Paul, Hasbani, Eduardo, Virani, Sean, Massih, Tony Abdel, Al-Saif, Shukri, Taborsky, Milos, Kaislerova, Marta, Motovska, Zuzana, Cohen, Aron Ariel, Logeart, Damien, Endemann, Dierk, Ferreira, Daniel, Brito, Dulce, Kycina, Peter, Bollano, Entela, Basilio, Enrique Galve, Rubio, Lorenzo Facila, Aguado, Marcos Garcia, Schiavi, Lilia Beatriz, Zivano, Daniel Francisco, Lonn, Eva, El Sayed, Ali, Pouleur, Anne-Catherine, Heyse, Alex, Schee, Alexandr, Polasek, Rostislav, Houra, Marek, Tribouilloy, Christophe, Seronde, Marie France, Galinier, Michel, Noutsias, Michel, Schwimmbeck, Peter, Voigt, Ingo, Westermann, Dirk, Pulignano, Giovanni, Vegsundvaag, Johnny, Da Silva Antunes, Jose Alexandre, Monteiro, Pedro, Stevlik, Jan, Goncalvesova, Eva, Hulkoova, Beata, Castro Fernandez, Antonio Juan, Davies, Ceri, Squire, Iain, Meyer, Philippe, Sheppard, Richard, Sahin, Tayfun, Sochor, Karel, De Geeter, Guillaume, Wachter, Rolf, Schmeisser, Alexander, Weil, Joachim, Soares, Ana Oliveira, Vasilevna, Olga Bulashova, Oshurkov, Andrey, Sunderland, Shahid Junejo, Glover, Jason, Exequiel, Tomas, Decoulx, Eric, Meyer, Sven, Muenzel, Thomas, Frioes, Fernando, Arbolishvili, Georgy, Tokarcikova, Anna, Karlstrom, Patric, Trullas Vila, Joan Carles, Perez, Gonzalo Pena, Sankaranarayanan, Rajiv, Nageh, Thuraia, Alasia, Diego Cristian, Refaat, Marwan, Demirkan, Burcu, Al-Buraiki, Jehad, Karabsheh, Shadi, Pascual-Figal, Domingo, Bao, Weibin, Noè, Adele, Schwende, Heike, Butylin, Dmytro, and Prescott, Margaret F.

Published
2020
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54. Heart rate as an independent predictor of long term mortality of acute heart failure patients in sinus rhythm according to their ejection fraction: data from the AHEAD registry

Author

Jarkovsky, Jiri, Spinar, Jindrich, Tyl, Benoit, Fougerousse, Françoise, Vitovec, Jiri, Linhart, Ales, Widimsky, Petr, Miklik, Roman, Spinarova, Lenka, Belohlavek, Jan, Malek, Filip, Felsoci, Marian, Kettner, Jiri, Ostadal, Petr, Vaclavik, Jan, Dusek, Ladislav, Lokaj, Petr, Mebazaa, Alexandre, Cohen Solal, Alain, and Parenica, Jiri

Published
2020
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55. Monitoring MCS patients on the intensive care unit: integrating haemodynamic assessment, laboratory data, and imaging techniques for timely detection of deterioration and recovery

Author

Vandenbriele, Christophe, primary, Baldetti, Luca, additional, Beneduce, Alessandro, additional, Belohlavek, Jan, additional, Hassager, Christian, additional, Pieri, Marina, additional, Polzin, Amin, additional, Scandroglio, Anna Mara, additional, and Møller, Jacob Eifer, additional

Published
2023
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56. The importance of timing in postcardiotomy venoarterial extracorporeal membrane oxygenation: A descriptive multicenter observational study

Author

Mariani, Silvia, primary, Wang, I-wen, additional, van Bussel, Bas C.T., additional, Heuts, Samuel, additional, Wiedemann, Dominik, additional, Saeed, Diyar, additional, van der Horst, Iwan C.C., additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J.H., additional, Buscher, Hergen, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Herr, Daniel, additional, Matteucci, Sacha, additional, Sponga, Sandro, additional, Ramanathan, Kollengode, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Jung, Jae-Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Shekar, Kiran, additional, Whitman, Glenn, additional, Lorusso, Roberto, additional, Ravaux, Justine, additional, Schaefer, Ann-Kristin, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean-Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Miranda, Dinis Dos Reis, additional, Sriranjan, Kogulan, additional, Mazzeffi, Michael A., additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, MacLaren, Graeme, additional, Sorokin, Vitaly, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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59. Lifestyle Walking Intervention in Patients With Heart Failure With Reduced Ejection Fraction: The WATCHFUL Trial

Author

Vetrovsky, Tomas, primary, Siranec, Michal, additional, Frybova, Tereza, additional, Gant, Iulian, additional, Svobodova, Iveta, additional, Linhart, Ales, additional, Parenica, Jiri, additional, Miklikova, Marie, additional, Sujakova, Lenka, additional, Pospisil, David, additional, Pelouch, Radek, additional, Odrazkova, Daniela, additional, Parizek, Petr, additional, Precek, Jan, additional, Hutyra, Martin, additional, Taborsky, Milos, additional, Vesely, Jiri, additional, Griva, Martin, additional, Semerad, Miroslav, additional, Bunc, Vaclav, additional, Hrabcova, Karolina, additional, Vojkuvkova, Adela, additional, Svoboda, Michal, additional, and Belohlavek, Jan, additional

Published
2023
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60. 425 The PRINCESS 2 trial: A randomized study to asses the impact of ultrafast hypothermia on neurologic function in out-of-hospital cardiac arrest with initial shockable rhythm

Author

Dillenbeck, Emelie, primary, Hollenberg, Jacob, additional, Holzer, Michael, additional, Busch, Hans-Jörg, additional, Nichol, Graham, additional, Radsel, Peter, additional, Belohlavek, Jan, additional, Forsberg, Sune, additional, Annoni, Filippo, additional, Svensson, Leif, additional, Jonsson, Martin, additional, Backström, Denise, additional, Gellerfors, Mikael, additional, Awad, Akil, additional, Taccone, Fabio, additional, and Nordberg, Per, additional

Published
2023
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61. On-Support and Postweaning Mortality in Postcardiotomy Extracorporeal Membrane Oxygenation

Author

Mariani, Silvia, primary, Schaefer, Anne-Kristin, additional, van Bussel, Bas C.T., additional, Di Mauro, Michele, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, De Piero, Maria Elena, additional, Heuts, Samuel, additional, Ravaux, Justine, additional, van der Horst, Iwan C.C., additional, Saeed, Diyar, additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J.H., additional, Buscher, Hergen, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Herr, Daniel, additional, Matteucci, Sacha, additional, Sponga, Sandro, additional, MacLaren, Graeme, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Wang, I-wen, additional, Jung, Jae-Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Whitman, Glenn, additional, Shekar, Kiran, additional, Wiedemann, Dominik, additional, Lorusso, Roberto, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean-Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Dos Reis Miranda, Dinis, additional, Sriranjan, Kogulan, additional, Mazzeffi, Michael A., additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, Sorokin, Vitaly, additional, Ramanathan, Kollengode, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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62. Effects of Hypothermia vs Normothermia on Societal Participation and Cognitive Function at 6 Months in Survivors After Out-of-Hospital Cardiac Arrest

Author

Lilja, Gisela, primary, Ullén, Susann, additional, Dankiewicz, Josef, additional, Friberg, Hans, additional, Levin, Helena, additional, Nordström, Erik Blennow, additional, Heimburg, Katarina, additional, Jakobsen, Janus Christian, additional, Ahlqvist, Marita, additional, Bass, Frances, additional, Belohlavek, Jan, additional, Olsen, Roy Bjørkholt, additional, Cariou, Alain, additional, Eastwood, Glenn, additional, Fanebust, Hans Rune, additional, Grejs, Anders M., additional, Grimmer, Lisa, additional, Hammond, Naomi E., additional, Hovdenes, Jan, additional, Hrecko, Juraj, additional, Iten, Manuela, additional, Johansen, Henriette, additional, Keeble, Thomas R., additional, Kirkegaard, Hans, additional, Lascarrou, Jean-Baptiste, additional, Leithner, Christoph, additional, Lesona, Mildred Eden, additional, Levis, Anja, additional, Mion, Marco, additional, Moseby-Knappe, Marion, additional, Navarra, Leanlove, additional, Nordberg, Per, additional, Pelosi, Paolo, additional, Quayle, Rachael, additional, Rylander, Christian, additional, Sandberg, Helena, additional, Saxena, Manoj, additional, Schrag, Claudia, additional, Siranec, Michal, additional, Tiziano, Cassina, additional, Vignon, Philippe, additional, Wendel-Garcia, Pedro David, additional, Wise, Matt P., additional, Wright, Kim, additional, Nielsen, Niklas, additional, and Cronberg, Tobias, additional

Published
2023
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65. Bilateral Femoral Cannulation Is Associated With Reduced Severe Limb Ischemia-Related Complications Compared With Unilateral Femoral Cannulation in Adult Peripheral Venoarterial Extracorporeal Membrane Oxygenation: Results From the Extracorporeal Life Support Registry*

Author

Simons, Jorik, primary, Di Mauro, Michele, additional, Mariani, Silvia, additional, Ravaux, Justine, additional, van der Horst, Iwan C. C., additional, Driessen, Rob G. H., additional, Sels, Jan Willem, additional, Delnoij, Thijs, additional, Brodie, Daniel, additional, Abrams, Darryl, additional, Mueller, Thomas, additional, Taccone, Fabio Silvio, additional, Belliato, Mirko, additional, Broman, Mike Lars, additional, Malfertheiner, Maximilian V., additional, Boeken, Udo, additional, Fraser, John, additional, Wiedemann, Dominik, additional, Belohlavek, Jan, additional, Barrett, Nicholas A., additional, Tonna, Joseph E., additional, Pappalardo, Federico, additional, Barbaro, Ryan P., additional, Ramanathan, Kollengode, additional, MacLaren, Graeme, additional, van Mook, Walther N. K. A., additional, Mees, Barend, additional, and Lorusso, Roberto, additional

Published
2023
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70. Patient and Management Variables Associated With Survival After Postcardiotomy Extracorporeal Membrane Oxygenation in Adults: The PELS‐1 Multicenter Cohort Study

Author

Mariani, Silvia, primary, Heuts, Samuel, additional, van Bussel, Bas C. T., additional, Di Mauro, Michele, additional, Wiedemann, Dominik, additional, Saeed, Diyar, additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J. H., additional, Buscher, Hergen, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Herr, Daniel, additional, Matteucci, Marco L. Sacha, additional, Sponga, Sandro, additional, MacLaren, Graeme, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Wang, I‐wen, additional, Jung, Jae‐Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Shekar, Kiran, additional, Whitman, Glenn J. R., additional, Lorusso, Roberto, additional, Ravaux, Justine, additional, Schaefer, Anne‐Kristin, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean‐Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Miranda, Dinis Dos Reis, additional, Sriranjan, Kogulan, additional, Mazzeffi, Michael A., additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, Sorokin, Vitaly, additional, Ramanathan, Kollengode, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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71. The Relation Between Obesity and Mortality in Postcardiotomy Venoarterial Membrane Oxygenation

Author

Heuts, Samuel, primary, Mariani, Silvia, additional, van Bussel, Bas C.T., additional, Boeken, Udo, additional, Samalavicius, Robertas, additional, Bounader, Karl, additional, Hou, Xiaotong, additional, Bunge, Jeroen J.H., additional, Sriranjan, Kogulan, additional, Wiedemann, Dominik, additional, Saeed, Diyar, additional, Pozzi, Matteo, additional, Loforte, Antonio, additional, Salazar, Leonardo, additional, Meyns, Bart, additional, Mazzeffi, Michael A., additional, Matteucci, Sacha, additional, Sponga, Sandro, additional, Sorokin, Vitaly, additional, Russo, Claudio, additional, Formica, Francesco, additional, Sakiyalak, Pranya, additional, Fiore, Antonio, additional, Camboni, Daniele, additional, Raffa, Giuseppe Maria, additional, Diaz, Rodrigo, additional, Wang, I-wen, additional, Jung, Jae-Seung, additional, Belohlavek, Jan, additional, Pellegrino, Vin, additional, Bianchi, Giacomo, additional, Pettinari, Matteo, additional, Barbone, Alessandro, additional, Garcia, José P., additional, Shekar, Kiran, additional, Whitman, Glenn, additional, Lorusso, Roberto, additional, Ravaux, Justine, additional, di Mauro, Michele, additional, Schaefer, Ann-Kristin, additional, Conci, Luca, additional, Szalkiewicz, Philipp, additional, Khalil, Jawad, additional, Lehmann, Sven, additional, Obadia, Jean-Francois, additional, Kalampokas, Nikolaos, additional, Flecher, Erwan, additional, Reis Miranda, Dinis Dos, additional, Buscher, Hergen, additional, Herr, Daniel, additional, Vedadi, Nazli, additional, Di Eusanio, Marco, additional, Maclaren, Graeme, additional, Ramanathan, Ram, additional, Costetti, Alessandro, additional, Schmid, Chistof, additional, Castillo, Roberto, additional, Mikulenka, Vladimir, additional, and Solinas, Marco, additional

Published
2023
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74. Cardiac Arrest Centers: Joint statement of Czech Professional Societies: Czech Acute Cardiac Care Association of the Czech Society of Cardiology, Czech Resuscitation Council, Czech Society of Intensive Care Medicine ČLS JEP, Czech Society of Anesthesiology, Resuscitation and Intensive Care Medicine ČLS JEP, and Society for Emergency and Disaster Medicine ČLS JEP

Author

Ošťádal, Petr, Rokyta, Richard, Balík, Martin, Bělohlávek, Jan, Cvachovec, Karel, Černý, Vladimír, Dostál, Pavel, Janota, Tomáš, Kala, Petr, Matějovič, Martin, Pařenica, Jiří, Šeblová, Jana, Škulec, Roman, Šrámek, Vladimír, and Truhlář, Anatolij

Published
2017
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76. Corrigendum to “Expert consensus on training and accreditation for extracorporeal cardiopulmonary resuscitation an international, multidisciplinary modified Delphi Study” [Resuscitation 192 (2023) 109989]

Author

Kruit, Natalie, Burrell, Aidan, Tian, David, Barrett, Nicholas, Bělohlávek, Jan, Bernard, Stephen, Braude, Darren, Buscher, Hergen, Chen, Yih-Sharng, Donker, Dirk W., Finney, Simon, Forrest, Paul, Fowles, Jo-anne, Hifumi, Toru, Hodgson, Carol, Hutin, Alice, Inoue, Akihiko, Jung, Jae-Seung, Kruse, JM, Lamhaut, Lionel, Ming-Hui Lin, Richard, Reis Miranda, Dinis, Müller, Thomas, Bhagyalakshmi Nanjayya, Vinodh, Nickson, Christopher, Pellegrino, Vin, Plunkett, Brian, Richardson, Carla, Alexander Richardson, Sacha, Shekar, Kiran, Shinar, Zachary, Singer, Ben, Stub, Dion, Totaro, Richard J, Vuylsteke, Alain, Yannopoulos, Demetris, Zakhary, Bishoy, and Dennis, Mark

Published
2024
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78. Position paper for the organization of ECMO programs for cardiac failure in adults

Author

Abrams, Darryl, Garan, A. Reshad, Abdelbary, Akram, Bacchetta, Matthew, Bartlett, Robert H., Beck, James, and Belohlavek, Jan

Subjects
United States. National Library of Medicine, Medical research -- Usage, Medicine, Experimental -- Usage, Medical colleges -- Usage, Adults -- Usage, Heart -- Usage, Cardiac patients -- Care and treatment, Heart failure -- Care and treatment, Health care industry
Abstract

Extracorporeal membrane oxygenation (ECMO) has been used increasingly for both respiratory and cardiac failure in adult patients. Indications for ECMO use in cardiac failure include severe refractory cardiogenic shock, refractory ventricular arrhythmia, active cardiopulmonary resuscitation for cardiac arrest, and acute or decompensated right heart failure. Evidence is emerging to guide the use of this therapy for some of these indications, but there remains a need for additional evidence to guide best practices. As a result, the use of ECMO may vary widely across centers. The purpose of this document is to highlight key aspects of care delivery, with the goal of codifying the current use of this rapidly growing technology. A major challenge in this field is the need to emergently deploy ECMO for cardiac failure, often with limited time to assess the appropriateness of patients for the intervention. For this reason, we advocate for a multidisciplinary team of experts to guide institutional use of this therapy and the care of patients receiving it. Rigorous patient selection and careful attention to potential complications are key factors in optimizing patient outcomes. Seamless patient transport and clearly defined pathways for transition of care to centers capable of providing heart replacement therapies (e.g., durable ventricular assist device or heart transplantation) are essential to providing the highest level of care for those patients stabilized by ECMO but unable to be weaned from the device. Ultimately, concentration of the most complex care at high-volume centers with advanced cardiac capabilities may be a way to significantly improve the care of this patient population., Author(s): Darryl Abrams [sup.1], A. Reshad Garan [sup.2], Akram Abdelbary [sup.3], Matthew Bacchetta [sup.4], Robert H. Bartlett [sup.5], James Beck [sup.6], Jan Belohlavek [sup.7], Yih-Sharng Chen [sup.8], Eddy Fan [sup.9] [...]

Published
2018
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79. Propafenone versus Amiodarone for Supraventricular Arrhythmias in Septic Shock: A Randomised Controlled Trial

Author

Balik, Martin, primary, Maly, Michal, additional, Brozek, Tomas, additional, Rulisek, Jan, additional, Porizka, Michal, additional, Sachl, Robert, additional, Otahal, Michal, additional, Brestovansky, Petr, additional, Flaksa, Marek, additional, Horejsek, Jan, additional, Svobodova, Eva, additional, Stach, Zdenek, additional, Volny, Lukas, additional, Jurisinova, Ivana, additional, Novotny, Adam, additional, Trachta, Pavel, additional, Kunstyr, Jan, additional, Kopecky, Petr, additional, Tencer, Tomas, additional, Pazout, Jaroslav, additional, Belohlavek, Jan, additional, Duska, Frantisek, additional, Krajcova, Adela, additional, and Waldauf, Petr, additional

Published
2023
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82. GEOGRAPHICAL VARIATION IN PATIENT CHARACTERISTICS AND OUTCOMES IN HFPEF

Author

McMurray, John J.V., primary, Yang, Mingming, additional, Kondo, Toru, additional, Jhund, Pardeep, additional, Gamba, Marco Antonio Alcocer, additional, Belohlavek, Jan, additional, Borleffs, Jan Willem, additional, Chiang, Chern-En, additional, Colet, Josep Comin, additional, Desai, Akshay S., additional, Dobreanu, Dan, additional, Drozdz, Jaroslaw, additional, Han, Yaling, additional, Janssens, Stefan P., additional, Katova, Tzvetana M., additional, Kosiborod, Mikhail, additional, Lam, Carolyn S.P., additional, Langkilde, Anna Maria, additional, Merkely, Bela, additional, Pham, Vinh, additional, thierer, jorge, additional, Vaduganathan, Muthiah, additional, Verma, Subodh, additional, and Solomon, Scott D., additional

Published
2023
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83. Effects of Hypothermia vs Normothermia on Societal Participation and Cognitive Function at 6 Months in Survivors After Out-of-Hospital Cardiac Arrest : A Predefined Analysis of the TTM2 Randomized Clinical Trial.

Author

Lilja, Gisela, Ullén, Susann, Dankiewicz, Josef, Friberg, Hans, Levin, Helena, Nordström, Erik Blennow, Heimburg, Katarina, Jakobsen, Janus Christian, Ahlqvist, Marita, Bass, Frances, Belohlavek, Jan, Olsen, Roy Bjørkholt, Cariou, Alain, Eastwood, Glenn, Fanebust, Hans Rune, Grejs, Anders M, Grimmer, Lisa, Hammond, Naomi E, Hovdenes, Jan, Hrecko, Juraj, Iten, Manuela, Johansen, Henriette, Keeble, Thomas R, Kirkegaard, Hans, Lascarrou, Jean-Baptiste, Leithner, Christoph, Lesona, Mildred Eden, Levis, Anja, Mion, Marco, Moseby-Knappe, Marion, Navarra, Leanlove, Nordberg, Per, Pelosi, Paolo, Quayle, Rachael, Rylander, Christian, Sandberg, Helena, Saxena, Manoj, Schrag, Claudia, Siranec, Michal, Tiziano, Cassina, Vignon, Philippe, Wendel-Garcia, Pedro David, Wise, Matt P, Wright, Kim, Nielsen, Niklas, Cronberg, Tobias, Lilja, Gisela, Ullén, Susann, Dankiewicz, Josef, Friberg, Hans, Levin, Helena, Nordström, Erik Blennow, Heimburg, Katarina, Jakobsen, Janus Christian, Ahlqvist, Marita, Bass, Frances, Belohlavek, Jan, Olsen, Roy Bjørkholt, Cariou, Alain, Eastwood, Glenn, Fanebust, Hans Rune, Grejs, Anders M, Grimmer, Lisa, Hammond, Naomi E, Hovdenes, Jan, Hrecko, Juraj, Iten, Manuela, Johansen, Henriette, Keeble, Thomas R, Kirkegaard, Hans, Lascarrou, Jean-Baptiste, Leithner, Christoph, Lesona, Mildred Eden, Levis, Anja, Mion, Marco, Moseby-Knappe, Marion, Navarra, Leanlove, Nordberg, Per, Pelosi, Paolo, Quayle, Rachael, Rylander, Christian, Sandberg, Helena, Saxena, Manoj, Schrag, Claudia, Siranec, Michal, Tiziano, Cassina, Vignon, Philippe, Wendel-Garcia, Pedro David, Wise, Matt P, Wright, Kim, Nielsen, Niklas, and Cronberg, Tobias

Abstract

IMPORTANCE: The Targeted Hypothermia vs Targeted Normothermia After Out-of-Hospital Cardiac Arrest (TTM2) trial reported no difference in mortality or poor functional outcome at 6 months after out-of-hospital cardiac arrest (OHCA). This predefined exploratory analysis provides more detailed estimation of brain dysfunction for the comparison of the 2 intervention regimens. OBJECTIVES: To investigate the effects of targeted hypothermia vs targeted normothermia on functional outcome with focus on societal participation and cognitive function in survivors 6 months after OHCA. DESIGN, SETTING, AND PARTICIPANTS: This study is a predefined analysis of an international multicenter, randomized clinical trial that took place from November 2017 to January 2020 and included participants at 61 hospitals in 14 countries. A structured follow-up for survivors performed at 6 months was by masked outcome assessors. The last follow-up took place in October 2020. Participants included 1861 adult (older than 18 years) patients with OHCA who were comatose at hospital admission. At 6 months, 939 of 1861 were alive and invited to a follow-up, of which 103 of 939 declined or were missing. INTERVENTIONS: Randomization 1:1 to temperature control with targeted hypothermia at 33 °C or targeted normothermia and early treatment of fever (37.8 °C or higher). MAIN OUTCOMES AND MEASURES: Functional outcome focusing on societal participation assessed by the Glasgow Outcome Scale Extended ([GOSE] 1 to 8) and cognitive function assessed by the Montreal Cognitive Assessment ([MoCA] 0 to 30) and the Symbol Digit Modalities Test ([SDMT] z scores). Higher scores represent better outcomes. RESULTS: At 6 months, 836 of 939 survivors with a mean age of 60 (SD, 13) (range, 18 to 88) years (700 of 836 male [84%]) participated in the follow-up. There were no differences between the 2 intervention groups in functional outcome focusing on societal participation (GOSE score, odds ratio, 0.91; 95% CI, 0.71-1.17; P =

Published
2023
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84. Patient and Management Variables Associated With Survival After Postcardiotomy Extracorporeal Membrane Oxygenation in Adults:The PELS-1 Multicenter Cohort Study

Author

Mariani, Silvia, Heuts, Samuel, van Bussel, Bas C.T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Marco L.Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., Lorusso, Roberto, Mariani, Silvia, Heuts, Samuel, van Bussel, Bas C.T., Di Mauro, Michele, Wiedemann, Dominik, Saeed, Diyar, Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Marco L.Sacha, Sponga, Sandro, MacLaren, Graeme, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Wang, I. Wen, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn J.R., and Lorusso, Roberto

Abstract

Background Extracorporeal membrane oxygenation (ECMO) has been increasingly used for postcardiotomy cardiogenic shock, but without a concomitant reduction in observed in-hospital mortality. Long-term outcomes are unknown. This study describes patients' characteristics, in-hospital outcome, and 10-year survival after postcardiotomy ECMO. Variables associated with in-hospital and postdischarge mortality are investigated and reported. Methods and Results The retrospective international multicenter observational PELS-1 (Postcardiotomy Extracorporeal Life Support) study includes data on adults requiring ECMO for postcardiotomy cardiogenic shock between 2000 and 2020 from 34 centers. Variables associated with mortality were estimated preoperatively, intraoperatively, during ECMO, and after the occurrence of any complications, and then analyzed at different time points during a patient's clinical course, through mixed Cox proportional hazards models containing fixed and random effects. Follow-up was established by institutional chart review or contacting patients. This analysis included 2058 patients (59% were men; median [interquartile range] age, 65.0 [55.0-72.0] years). In-hospital mortality was 60.5%. Independent variables associated with in-hospital mortality were age (hazard ratio [HR], 1.02 [95% CI, 1.01-1.02]) and preoperative cardiac arrest (HR, 1.41 [95% CI, 1.15-1.73]). In the subgroup of hospital survivors, the overall 1-, 2-, 5-, and 10-year survival rates were 89.5% (95% CI, 87.0%-92.0%), 85.4% (95% CI, 82.5%-88.3%), 76.4% (95% CI, 72.5%-80.5%), and 65.9% (95% CI, 60.3%-72.0%), respectively. Variables associated with postdischarge mortality included older age, atrial fibrillation, emergency surgery, type of surgery, postoperative acute kidney injury, and postoperative septic shock. Conclusions In adults, in-hospital mortality after postcardiotomy ECMO remains high; however, two-thirds of those who are discharged from hospital survive up to 10 years. Patien

Published
2023

85. Serum lactate in refractory out-of-hospital cardiac arrest:Post-hoc analysis of the Prague OHCA study

Author

Dusik, Milan, Rob, Daniel, Smalcova, Jana, Havranek, Stepan, Karasek, Jiri, Smid, Ondrej, Brodska, Helena Lahoda, Kavalkova, Petra, Huptych, Michal, Bakker, Jan, Belohlavek, Jan, Dusik, Milan, Rob, Daniel, Smalcova, Jana, Havranek, Stepan, Karasek, Jiri, Smid, Ondrej, Brodska, Helena Lahoda, Kavalkova, Petra, Huptych, Michal, Bakker, Jan, and Belohlavek, Jan

Abstract

Background: The severity of tissue hypoxia is routinely assessed by serum lactate. We aimed to determine whether early lactate levels predict outcomes in refractory out-of-hospital cardiac arrest (OHCA) treated by conventional and extracorporeal cardiopulmonary resuscitation (ECPR). Methods: This study is a post-hoc analysis of a randomized Prague OHCA study (NCT01511666) assessing serum lactate levels in refractory OHCA treated by ECPR (the ECPR group) or conventional resuscitation with prehospital achieved return of spontaneous circulation (the ROSC group). Lactate concentrations measured on admission and every 4 hours (h) during the first 24 h were used to determine their relationship with the neurological outcome (the best Cerebral Performance Category score within 180 days post-cardiac arrest). Results:In the ECPR group (92 patients, median age 58.5 years, 83% male) 26% attained a favorable neurological outcome. In the ROSC group (82 patients, median age 55 years, 83% male) 59% achieved a favorable neurological outcome. In ECPR patients lactate concentrations could discriminate favorable outcome patients, but not consistently in the ROSC group. On admission, serum lactate >14.0 mmol/L for ECPR (specificity 87.5%, sensitivity 54.4%) and >10.8 mmol/L for the ROSC group (specificity 83%, sensitivity 41.2%) predicted an unfavorable outcome. Conclusion: In refractory OHCA serum lactate concentrations measured anytime during the first 24 h after admission to the hospital were found to correlate with the outcome in patients treated by ECPR but not in patients with prehospital ROSC. A single lactate measurement is not enough for a reliable outcome prediction and cannot be used alone to guide treatment.

Published
2023

86. The importance of timing in postcardiotomy venoarterial extracorporeal membrane oxygenation:A descriptive multicenter observational study

Author

Mariani, Silvia, Wang, I. wen, van Bussel, Bas C.T., Heuts, Samuel, Wiedemann, Dominik, Saeed, Diyar, van der Horst, Iwan C.C., Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, Lorusso, Roberto, Miranda, Dinis Dos Reis, Mariani, Silvia, Wang, I. wen, van Bussel, Bas C.T., Heuts, Samuel, Wiedemann, Dominik, Saeed, Diyar, van der Horst, Iwan C.C., Pozzi, Matteo, Loforte, Antonio, Boeken, Udo, Samalavicius, Robertas, Bounader, Karl, Hou, Xiaotong, Bunge, Jeroen J.H., Buscher, Hergen, Salazar, Leonardo, Meyns, Bart, Herr, Daniel, Matteucci, Sacha, Sponga, Sandro, Ramanathan, Kollengode, Russo, Claudio, Formica, Francesco, Sakiyalak, Pranya, Fiore, Antonio, Camboni, Daniele, Raffa, Giuseppe Maria, Diaz, Rodrigo, Jung, Jae Seung, Belohlavek, Jan, Pellegrino, Vin, Bianchi, Giacomo, Pettinari, Matteo, Barbone, Alessandro, Garcia, José P., Shekar, Kiran, Whitman, Glenn, Lorusso, Roberto, and Miranda, Dinis Dos Reis

Abstract

Objectives: Postcardiotomy extracorporeal membrane oxygenation (ECMO) can be initiated intraoperatively or postoperatively based on indications, settings, patient profile, and conditions. The topic of implantation timing only recently gained attention from the clinical community. We compare patient characteristics as well as in-hospital and long-term survival between intraoperative and postoperative ECMO.Methods: The retrospective, multicenter, observational Postcardiotomy Extracorporeal Life Support (PELS-1) study includes adults who required ECMO due to postcardiotomy shock between 2000 and 2020. We compared patients who received ECMO in the operating theater (intraoperative) with those in the intensive care unit (postoperative) on in-hospital and postdischarge outcomes. Results: We studied 2003 patients (women: 41.1%; median age: 65 years; interquartile range [IQR], 55.0-72.0). Intraoperative ECMO patients (n = 1287) compared with postoperative ECMO patients (n = 716) had worse preoperative risk profiles. Cardiogenic shock (45.3%), right ventricular failure (15.9%), and cardiac arrest (14.3%) were the main indications for postoperative ECMO initiation, with cannulation occurring after (median) 1 day (IQR, 1-3 days). Compared with intraoperative application, patients who received postoperative ECMO showed more complications, cardiac reoperations (intraoperative: 19.7%; postoperative: 24.8%, P = .011), percutaneous coronary interventions (intraoperative: 1.8%; postoperative: 3.6%, P = .026), and had greater in-hospital mortality (intraoperative: 57.5%; postoperative: 64.5%, P = .002). Among hospital survivors, ECMO duration was shorter after intraoperative ECMO (median, 104; IQR, 67.8-164.2 hours) compared with postoperative ECMO (median, 139.7; IQR, 95.8-192 hours, P < .001), whereas postdischarge long-term survival was similar between the 2 groups (P = .86). Conclusions: Intraopera

Published
2023

87. Effects of Hypothermia vs Normothermia on Societal Participation and Cognitive Function at 6 Months in Survivors After Out-of-Hospital Cardiac Arrest

Author

Lilja, Gisela, Ullén, Susann, Dankiewicz, Josef, Friberg, Hans, Levin, Helena, Nordström, Erik Blennow, Heimburg, Katarina, Jakobsen, Janus Christian, Ahlqvist, Marita, Bass, Frances, Belohlavek, Jan, Olsen, Roy Bjørkholt, Cariou, Alain, Eastwood, Glenn, Fanebust, Hans Rune, Grejs, Anders M, Grimmer, Lisa, Hammond, Naomi E, Hovdenes, Jan, Hrecko, Juraj, Iten, Manuela, Johansen, Henriette, Keeble, Thomas R, Kirkegaard, Hans, Lascarrou, Jean-Baptiste, Leithner, Christoph, Lesona, Mildred Eden, Levis, Anja, Mion, Marco, Moseby-Knappe, Marion, et al, Wendel-Garcia, Pedro David; https://orcid.org/0000-0001-7775-3279, Lilja, Gisela, Ullén, Susann, Dankiewicz, Josef, Friberg, Hans, Levin, Helena, Nordström, Erik Blennow, Heimburg, Katarina, Jakobsen, Janus Christian, Ahlqvist, Marita, Bass, Frances, Belohlavek, Jan, Olsen, Roy Bjørkholt, Cariou, Alain, Eastwood, Glenn, Fanebust, Hans Rune, Grejs, Anders M, Grimmer, Lisa, Hammond, Naomi E, Hovdenes, Jan, Hrecko, Juraj, Iten, Manuela, Johansen, Henriette, Keeble, Thomas R, Kirkegaard, Hans, Lascarrou, Jean-Baptiste, Leithner, Christoph, Lesona, Mildred Eden, Levis, Anja, Mion, Marco, Moseby-Knappe, Marion, et al, and Wendel-Garcia, Pedro David; https://orcid.org/0000-0001-7775-3279

Abstract

ImportanceThe Targeted Hypothermia vs Targeted Normothermia After Out-of-Hospital Cardiac Arrest (TTM2) trial reported no difference in mortality or poor functional outcome at 6 months after out-of-hospital cardiac arrest (OHCA). This predefined exploratory analysis provides more detailed estimation of brain dysfunction for the comparison of the 2 intervention regimens.ObjectivesTo investigate the effects of targeted hypothermia vs targeted normothermia on functional outcome with focus on societal participation and cognitive function in survivors 6 months after OHCA.Design, Setting, and ParticipantsThis study is a predefined analysis of an international multicenter, randomized clinical trial that took place from November 2017 to January 2020 and included participants at 61 hospitals in 14 countries. A structured follow-up for survivors performed at 6 months was by masked outcome assessors. The last follow-up took place in October 2020. Participants included 1861 adult (older than 18 years) patients with OHCA who were comatose at hospital admission. At 6 months, 939 of 1861 were alive and invited to a follow-up, of which 103 of 939 declined or were missing.InterventionsRandomization 1:1 to temperature control with targeted hypothermia at 33 °C or targeted normothermia and early treatment of fever (37.8 °C or higher).Main outcomes and measuresFunctional outcome focusing on societal participation assessed by the Glasgow Outcome Scale Extended ([GOSE] 1 to 8) and cognitive function assessed by the Montreal Cognitive Assessment ([MoCA] 0 to 30) and the Symbol Digit Modalities Test ([SDMT] z scores). Higher scores represent better outcomes.ResultsAt 6 months, 836 of 939 survivors with a mean age of 60 (SD, 13) (range, 18 to 88) years (700 of 836 male [84%]) participated in the follow-up. There were no differences between the 2 intervention groups in functional outcome focusing on societal participation (GOSE score, odds ratio, 0.91; 95% CI, 0.71-1.17; P = .46) or in cogni

Published
2023

89. AHEAD score — Long-term risk classification in acute heart failure

Author

Spinar, Jindrich, Jarkovsky, Jiri, Spinarova, Lenka, Mebazaa, Alexandre, Gayat, Etienne, Vitovec, Jiri, Linhart, Ales, Widimsky, Petr, Miklik, Roman, Zeman, Kamil, Belohlavek, Jan, Malek, Filip, Felsoci, Marian, Kettner, Jiri, Ostadal, Petr, Cihalik, Cestmir, Vaclavik, Jan, Taborsky, Miloš, Dusek, Ladislav, Littnerova, Simona, and Parenica, Jiri

Published
2016
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90. Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey

Author

Fleig, Marcel, primary, Müller, Thomas, additional, Antonini, Velia M, additional, Riera, Jordi, additional, Belliato, Mirko, additional, Broman, Lars Mikael, additional, Fowles, Jo-Anne, additional, Belohlavek, Jan, additional, Lorusso, Roberto, additional, Vercaemst, Leen, additional, Jones, Tim, additional, Roeleveld, Peter P, additional, Di Nardo, Matteo, additional, Barrett, Nicholas, additional, and Swol, Justyna, additional

Published
2023
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92. Supplemental Material - GEospatial aNalysis of ExtRacorporeal membrane oxygenATion in Europe (GENERATE)

Author

Gillon, Stuart, Zheng, Chunyu, Feng, Zhiqiang, Fleig, Marcel, Scquizzato, Tommaso, Belohlavek, Jan, Lorusso, Roberto, Lone, Nazir, and Swol, Justyna

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery
Abstract

Supplemental Material for GEospatial aNalysis of ExtRacorporeal membrane oxygenATion in Europe (GENERATE) by Stuart Gillon, Chunyu Zheng, Zhiqiang Feng, Marcelcel Fleig, Tommaso Scquizzato, Jan Belohlavek, Roberto Lorusso, Nazir Lone, and Justyna Swol in Perfusion

Published
2023
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94. Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: Results of the ECMO-CS Randomized Clinical Trial

Author

Ostadal, Petr, primary, Rokyta, Richard, additional, Karasek, Jiri, additional, Kruger, Andreas, additional, Vondrakova, Dagmar, additional, Janotka, Marek, additional, Naar, Jan, additional, Smalcova, Jana, additional, Hubatova, Marketa, additional, Hromadka, Milan, additional, Volovar, Stefan, additional, Seyfrydova, Miroslava, additional, Jarkovsky, Jiri, additional, Svoboda, Michal, additional, Linhart, Ales, additional, and Belohlavek, Jan, additional

Published
2022
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95. In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study

Author

Lorusso, Roberto, primary, De Piero, Maria Elena, additional, Mariani, Silvia, additional, Di Mauro, Michele, additional, Folliguet, Thierry, additional, Taccone, Fabio Silvio, additional, Camporota, Luigi, additional, Swol, Justyna, additional, Wiedemann, Dominik, additional, Belliato, Mirko, additional, Broman, Lars Mikael, additional, Vuylsteke, Alain, additional, Kassif, Yigal, additional, Scandroglio, Anna Mara, additional, Fanelli, Vito, additional, Gaudard, Philippe, additional, Ledot, Stephane, additional, Barker, Julian, additional, Boeken, Udo, additional, Maier, Sven, additional, Kersten, Alexander, additional, Meyns, Bart, additional, Pozzi, Matteo, additional, Pedersen, Finn M, additional, Schellongowski, Peter, additional, Kirali, Kaan, additional, Barrett, Nicholas, additional, Riera, Jordi, additional, Mueller, Thomas, additional, Belohlavek, Jan, additional, Lorusso, Roberto, additional, Lo Coco, Valeria, additional, Van der Horst, Iwan C C, additional, Van Bussel, Bas C T, additional, Schnabel, Ronny M, additional, Delnoij, Thijs, additional, Bolotin, Gil, additional, Lorini, Luca, additional, Schmiady, Martin O, additional, Schibilsky, David, additional, Kowalewski, Mariusz, additional, Pinto, Luis F, additional, Silva, Pedro E, additional, Kornilov, Igor, additional, Blandino Ortiz, Aaron, additional, Vercaemst, Leen, additional, Finney, Simon, additional, Roeleveld, Peter P, additional, Di Nardo, Matteo, additional, Hennig, Felix, additional, Antonini, Marta Velia, additional, Davidson, Mark, additional, Jones, Tim J, additional, Staudinger, Thomas, additional, Mair, Peter, additional, Kilo, Juliane, additional, Krapf, Christoph, additional, Erbert, Kathrin, additional, Peer, Andreas, additional, Bonaros, Nikolaos, additional, Kotheletner, Florian, additional, Krenner Mag, Niklas, additional, Shestakova, Liana, additional, Hermans, Greet, additional, Dauwe, Dieter, additional, Meersseman, Philippe, additional, Stockman, Bernard, additional, Nobile, Leda, additional, Lhereux, Olivier, additional, Nrasseurs, Alexandre, additional, Creuter, Jacques, additional, De Backer, Daniel, additional, Giglioli, Simone, additional, Michiels, Gregoire, additional, Foulon, Pierre, additional, Raes, Matthias, additional, Rodrigus, Inez, additional, Allegaert, Matthias, additional, Jorens, Philippe, additional, Debeucklare, Gerd, additional, Piagnarelli, Michael, additional, Biston, Patrick, additional, Peperstraete, Harlinde, additional, Vandewiele, Komeel, additional, Germay, Olivier, additional, Vandeweghe, Dimitri, additional, Havrin, Sven, additional, Bourgeois, Marc, additional, Lagny, Marc-Gilbert, additional, Alois, Genette, additional, Lavios, Nathalie, additional, Misset, Benoit, additional, Courcelle, Romain, additional, Timmermans, Philippe J, additional, Yilmaz, Alaaddin, additional, Vantomout, Michiel, additional, Lehaen, Jerone, additional, Jassen, Ame, additional, Guterman, Herbert, additional, Strauven, Maarten, additional, Lormans, Piet, additional, Verhamme, Bruno, additional, Vandewaeter, catherine, additional, Bonte, Frederik, additional, Vionne, Dominique, additional, Balik, Martin, additional, Blàha, Jan, additional, Lips, Michal, additional, Othal, Michal, additional, Bursa, Filip, additional, Spacek, Radim, additional, Christensen, Steffen, additional, Jorgensen, Vibeke, additional, Sorensen, Marc, additional, Madsen, Soren A, additional, Puss, Severin, additional, Beljantsev, Aleksandr, additional, Saiydoun, gabriel, additional, Fiore, Antonio, additional, Colson, Pascal, additional, Bazalgette, Florian, additional, Capdevila, Xavier, additional, Kollen, Sebastien, additional, Muller, Laurent, additional, Obadia, Jean-Francois, additional, Dubien, Pierre-Yves, additional, Ajrhourh, Lucrezia, additional, Guinot, Pierre G, additional, Zarka, Jonathan, additional, Besserve, Patricia, additional, Malfertheiner, Maximilian V, additional, Dreier, Esther, additional, Heinze, Birgit, additional, Akhyari, Payam, additional, Lichtenberg, Artur, additional, Aubin, Hug, additional, Assman, Alexander, additional, Saeed, Diyar, additional, Thiele, Holger, additional, Baumgaertel, Matthias, additional, Schmitto, Jan D, additional, Ruslan, Natanov, additional, Haverich, Axel, additional, Thielmann, Matthias, additional, Brenner, Thorsten, additional, Ruhpawar, Arjang, additional, Benk, Christoph, additional, Czerny, Martin, additional, Staudacher, Dawid L, additional, Beyersdorf, Fridhelm, additional, Kalbhenn, Johannes, additional, Henn, Philipp, additional, Popov, Aron-Frederik, additional, Iuliu, Torje, additional, Muellenbach, Ralf, additional, Reyher, Christian, additional, Rolfes, Caroline, additional, Lotz, Gosta, additional, Sonntagbauer, Michael, additional, Winkels, Helen, additional, Fichte, Julia, additional, Stohr, Robert, additional, Kalverkamp, Sebastian, additional, Karagiannidis, Christian, additional, Schafer, Simone, additional, Svetlitchny, Alexei, additional, Hopf, Hans-Bernd, additional, Jarczak, Dominik, additional, Groesdonk, Heinirich, additional, Rommer, Magdalena, additional, Hirsch, Jan, additional, Kaehny, Christian, additional, Soufleris, Dimitros, additional, Gavriilidis, Georgios, additional, Pontikis, Kostantinos, additional, Kyriakopoulou, Magdalini, additional, Kyriakoudi, Anna, additional, O'Brien, Serena, additional, Conrick-Martin, Ian, additional, Carton, Edmund, additional, Makhoul, Maged, additional, Ben-Ari, Josef, additional, Hadash, Amir, additional, Kogan, Alexander, additional, Kassif Lerner, Reut, additional, Abu-Shakra, Anas, additional, Matan, Moshe, additional, Balawona, Ahmad, additional, Kachel, Erez, additional, Altshuler, Roman, additional, Galante, Ori, additional, Fuchs, Lior, additional, Almog, Yaniv, additional, Ishay, Yaron S, additional, Lichter, Yael, additional, Gal-oz, Amir, additional, Carmi, Uri, additional, Nini, Asaph, additional, Soroksky, Arie, additional, Dekel, Hagi, additional, Rozman, Ziv, additional, Tayem, Emad, additional, Ilgiyaev, Eduard, additional, Hochman, Yuval, additional, Miltau, daniel, additional, Rapoport, Avigal, additional, Eden, Arieh, additional, Kompanietz, Dmitry, additional, Yousif, Michael, additional, Golos, Miri, additional, Grazioli, Lorenzo, additional, Ghitti, Davide, additional, Loforte, Antonio, additional, Di Luca, Daniela, additional, Baiocchi, Massimo, additional, Pacini, Davide, additional, Cappai, Antioco, additional, Meani, Paolo, additional, Mondino, Michele, additional, Russo, Claudio F, additional, Ranucci, Marco, additional, Fina, Dario, additional, Cotza, Marco, additional, Ballotta, Andrea, additional, Landoni, Giovanni, additional, Nardelli, Pasquale, additional, Fominski, Eygeny V, additional, Brazzi, Luca, additional, Montrucchio, Giorgia, additional, Sales, Gabriele, additional, Simonetti, Umberto, additional, Livigni, Sergio, additional, Silengo, Daniela, additional, Arena, Giulia, additional, Sovatzis, Stefania S, additional, Degani, Antonella, additional, Riccardi, Mariachiara, additional, Milanesi, Elisa, additional, Raffa, Giuseppe, additional, Martucci, Gennaro, additional, Arcadipane, Antonio, additional, Panarello, Giovanna, additional, Chiarini, Giovanni, additional, Cattaneo, Sergio, additional, Puglia, Carmine, additional, Benussi, Stefano, additional, Foti, Giuseppe, additional, Giani, Marco, additional, Bombino, Michela, additional, Costa, Maria Cristina, additional, Rona, Roberto, additional, Avalli, Leonello, additional, Donati, Abele, additional, Carozza, Roberto, additional, Gasparri, Francesco, additional, Carsetti, Andrea, additional, Picichè, Marco, additional, Marinello, Anna, additional, Danzi, Vinicio, additional, Zanin, Anita, additional, Condello, Ignazio, additional, Fiore, Flavio, additional, Moscarelli, Marco, additional, Nasso, Giuseppe, additional, Speziale, Giuseppe, additional, Sandrelli, Luca, additional, Montalto, Andrea, additional, Musumeci, Francesco, additional, Circelli, Alessandro, additional, Russo, Emanuele, additional, Agnoletti, Vanni, additional, Rociola, Ruggero, additional, Milano, Aldo D, additional, Pilato, Emanuele, additional, Comentale, Giuseppe, additional, Montisci, Andrea, additional, Alessandri, Francesco, additional, Tosi, Antonella, additional, Pugliese, Francesco, additional, Giordano, Giovanni, additional, Carelli, Simone, additional, Grieco, Domenico L, additional, Dell'Anna, Antonio M, additional, Antonelli, Massimo, additional, Ramoni, Enrico, additional, Zulueta, Josè, additional, Del Giglio, Mauro, additional, Petracca, Sebastiano, additional, Bertini, Pietro, additional, Guarracino, Fabio, additional, De Simone, Luigi, additional, Angeletti, Paolo M, additional, Forfori, Francesco, additional, Taraschi, Francesco, additional, Quintiliani, Veronica N, additional, Samalavicius, Robertas, additional, Jankuviene, Agne, additional, Scupakova, Nadezda, additional, Urbonas, Karolis, additional, Kapturauskas, Juozas, additional, Soerensen, Gro, additional, Suwalski, Piotr, additional, Linhares Santos, Luis, additional, Marques, Ana, additional, Miranda, Marisa, additional, Teixeira, Sonia, additional, Salgueiro, Andrea, additional, Pereira, Filipe, additional, Ketskalo, Michail, additional, Tsarenko, Sergey, additional, Shilova, Alexandra, additional, Afukov, Ivan, additional, Popugaev, Konstantin, additional, Minin, Sergei, additional, Shelukhin, Daniil, additional, Malceva, Olga, additional, Gleb, Moroz, additional, Skopets, Alexander, additional, Kornelyuk, Roman, additional, Kulikov, Alexandr, additional, Okhrimchuk, Vadim, additional, Turchaninov, Alexandr, additional, Petrushin, Maxim, additional, Sheck, Anastasia, additional, Mekulov, Akhmed, additional, Ciryateva, Svetlana, additional, Urusov, Dmitry, additional, Gorjup, Vojka, additional, Golicnik, Alenka, additional, Goslar, Tomaz, additional, Ferrer, Ricard, additional, Martinez-Martinez, Maria, additional, Argudo, Eduard, additional, Palmer, Neiser, additional, De Pablo Sanchez, Raul, additional, Juan Higuera, Lucas, additional, Arnau Blasco, Lucas, additional, Marquez, Josè A, additional, Sbraga, Fabrizio, additional, Fuset, Mari Paz, additional, De Gopegui, Pablo Ruiz, additional, Claraco, Luis M, additional, De Ayala, Josè A, additional, Peiro, Maranta, additional, Ricart, Pilar, additional, Martinez, Sergio, additional, Chavez, Fernando, additional, Fabra, Marc, additional, Sandoval, elena, additional, Toapanta, David, additional, Carraminana, Albert, additional, Tellez, Adrian, additional, Ososio, Jeysson, additional, Milan, Pablo, additional, Rodriguez, Jorge, additional, Andoni, Garcia, additional, Gutierrez, Carola, additional, Perez de la Sota, Enrique, additional, Eixeres-Esteve, Andrea, additional, Garcia-Maellas, Maria Teresa, additional, Gutierrez-Gutierrez, Judit, additional, Arboleda-Salazar, Rafael, additional, Santa Teresa, Patricia, additional, Jaspe, Alexis, additional, Garrido, Alberto, additional, Castaneda, Galo, additional, Alcantara, Sara, additional, Martinez, Nuria, additional, Perez, Marina, additional, Villanueva, Hector, additional, Vidal Gonzalez, Anxela, additional, Paez, Juan, additional, Santon, Arnoldo, additional, Perez, Cesar, additional, Lopez, Marta, additional, Rubio Lopez, Maria Isabel, additional, Gordillo, Antonio, additional, Naranjo-Izurieta, Jose, additional, Munoz, Javier, additional, Alcalde, Immaculada, additional, Onieva, Fernando, additional, Gimeno Costa, Ricardo, additional, Perez, Francisco, additional, Madrid, Isabel, additional, Gordon, Monica, additional, Albacete Moreno, Carlos L, additional, Perez, Daniel, additional, Lopez, Nayara, additional, Martinenz, Domingo, additional, Blanco-Schweizer, Pablo, additional, Diez, Cristina, additional, Perez, David, additional, Prieto, Ana, additional, Renedo, Gloria, additional, Bustamante, Elena, additional, Cicuendez, Ramon, additional, Citores, Rafael, additional, Boado, Victoria, additional, Garcia, Katherine, additional, Voces, Roberto, additional, Domezain, Monica, additional, Nunez Martinez, Jose Maria, additional, Vicente, Raimundo, additional, Martin, David, additional, Andreu, Antonio, additional, Gomez Casal, Vanesa, additional, Chico, Ignacio, additional, Menor, Eva Maria, additional, Vara, Sabela, additional, Gamacho, Jose, additional, Perez-Chomon, Helen, additional, Javier Gonzales, Francisco, additional, Barrero, Irene, additional, Martin-Villen, Luis, additional, Fernandez, Esperanza, additional, Mendoza, Maria, additional, Navarro, Joaquin, additional, Colomina Climent, Joaquin, additional, Gonzales-Perez, Alfredo, additional, Muniz-Albaceita, Guillermo, additional, Amado, Laura, additional, Rodriguez, Raquel, additional, Ruiz, Emilio, additional, Eiras, Maria, additional, Grins, Edgars, additional, Magnus, Rosen, additional, Kanetoft, Mikael, additional, Eidevald, Marcus, additional, Watson, Pia, additional, Vogt, Paul R, additional, Steiger, Peter, additional, Aigner, Tobias, additional, Weber, Alberto, additional, Grunefelder, Jurg, additional, Kunz, Martin, additional, Grapow, Martin, additional, Aymard, Thierry, additional, Reser, Diana, additional, Agus, Gianluca, additional, Consiglio, Jolanda, additional, Haenggi, Matthias, additional, Hansjoerg, Jenni, additional, Iten, Manuela, additional, Doeble, Thomas, additional, Zenklusen, Urs, additional, Bechtold, Xavier, additional, Faedda, Giovanni, additional, Iafrate, Manuel, additional, Rohjer, Amanda, additional, Bergamaschi, Layla, additional, Maessen, Jos, additional, Reis Miranda, Dinis, additional, Endeman, H, additional, Gommers, D, additional, Meuwese, C, additional, Maas, Jacinta, additional, Van Gijlswijk, MJ, additional, Van Berg, RN, additional, Candura, Dario, additional, Van der Linden, Marcel, additional, Kant, Merijin, additional, Van der Heijden, JJ, additional, Scholten, Eric, additional, Van Belle-van Haren, Nicole, additional, Lagrand, WK, additional, Vlaar, Alexander P, additional, De Jong, Syste, additional, Cander, Basar, additional, Sargin, Murat, additional, Ugur, Murat, additional, Kaygin, Mehmet A, additional, Daly, Kathleen, additional, Agnew, Nicola, additional, Head, Laura, additional, Kelly, Laura, additional, Anoma, Gunawardena, additional, Russell, Clare, additional, Aquino, Verna, additional, Scott, Ian, additional, Flemming, Lucy, additional, Gillon, Stuart, additional, Moore, Olivia, additional, Gelandt, Elton, additional, Auzinger, George, additional, Patel, Sameer, additional, and Loveridge, Robert, additional

Published
2022
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96. A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction

Author

Rao, Sunil V., primary, Kirsch, Bodo, additional, Bhatt, Deepak L., additional, Budaj, Andrzej, additional, Coppolecchia, Rosa, additional, Eikelboom, John, additional, James, Stefan K., additional, Jones, W. Schuyler, additional, Merkely, Bela, additional, Keller, Lars, additional, Hermanides, Renicus S., additional, Campo, Gianluca, additional, Ferreiro, José Luis, additional, Shibasaki, Taro, additional, Mundl, Hardi, additional, Alexander, John H., additional, Hengstenberg, Christian, additional, Steinwender, Clemens, additional, Alber, Hannes, additional, Steringer-Mascherbauer, Regina, additional, Schober, Andreas, additional, Auer, Johann, additional, Roithinger, Franz Xaver, additional, von Lewinski, Dirk, additional, Moertl, Deddo, additional, Huber, Kurt, additional, Coussement, Patrick, additional, Hoffer, Etienne, additional, Beauloye, Christophe, additional, Janssens, Luc, additional, Vranckx, Pascal, additional, De Raedt, Herbert, additional, Vanassche, Thomas, additional, Vrolix, Matthias, additional, Rokyta, Richard, additional, Parenica, Jiri, additional, Pelouch, Radek, additional, Motovska, Zuzanna, additional, Alan, David, additional, Kettner, Jiri, additional, Polasek, Rostislav, additional, Cermak, Ondrej, additional, Sedlon, Pavel, additional, Hanis, Jiri, additional, Novak, Martin, additional, Belohlavek, Jan, additional, Horacek, Thomas, additional, Leggewie, Stefan, additional, Wenzel, Philip, additional, vom Dahl, Juergen, additional, Sievers, Burkhard, additional, Pulz, Jan, additional, Schellong, Sebastian, additional, Clemmensen, Peter, additional, Muller-Hennessen, Matthias, additional, Rassaf, Tienush, additional, Falukozi, Jozsef, additional, Ruzsa, Zoltan, additional, Tomcsanyi, Janos, additional, Csanadi, Zoltan, additional, Herczeg, Bela, additional, Koszegi, Zsolt, additional, Vorobcsuk, Andras, additional, Kiss, Robert, additional, Baranyai, Csaba, additional, Dezsi, Csaba, additional, Lupkovics, Geza, additional, Rossini, Roberta, additional, Scherillo, Marino, additional, Sergio Saba, Pier, additional, Calogero Campo, Gianluca, additional, Calo, Leonardo, additional, Nassiacos, Daniele, additional, Quadri, Giorgio, additional, Sciahbasi, Alessandro, additional, Silvio Marenzi, Gian Carlo, additional, Reimers, Bernhard, additional, Perna, Gian Piero, additional, Sacca, Salvatore, additional, Fattore, Luciano, additional, Brunelli, Claudio, additional, Picchi, Andrea, additional, Kuramochi, Takehiko, additional, Kondo, Kazuhisa, additional, Aoyama, Takahiko, additional, Kudoh, Takashi, additional, Yamamoto, Tadashi, additional, Takaya, Tomofumi, additional, Mukai, Yasushi, additional, Fukui, Kazuki, additional, Morioka, Nobuyuki, additional, Ando, Kenji, additional, Yamamuro, Atsushi, additional, Morita, Yasuhiro, additional, Koga, Yasuaki, additional, Watanabe, Tetsuya, additional, Sakamoto, Tomohiro, additional, Maebuchi, Daisuke, additional, Takahashi, Akihiko, additional, Yonetsu, Taishi, additional, Kakuta, Tsunekazu, additional, Nishina, Hidetaka, additional, Oemrawsingh, Rohit, additional, Dorman, Reinhart, additional, Oude Ophius, Ton, additional, Prins, Paco, additional, al Windy, N.Y.Y., additional, Zoet-Nugteren, S.K., additional, Hermanides, Rik, additional, van Eck, Martijn, additional, Scherptong, Roderick, additional, Cornel, J.H., additional, Damman, Peter, additional, Bech, Gerhard, additional, Torquay, R., additional, Kietselaer, Bas, additional, Grzelakowski, Pawel, additional, Krzysztof, Dyrbus, additional, Miekus, Pawel, additional, Przybylski, Andrzej, additional, Zarebinski, Maciej, additional, Balsam, Pawel, additional, Szachniewicz, Joanna, additional, Gierlotka, Marek, additional, Tycinska, Agnieszka, additional, Iniguez Romo, Andres, additional, Fernandez Ortiz, Antonio, additional, Carrasquer Cucarella, Anna, additional, Sanmartin Fernandez, Marcelo, additional, Sionis, Alessandro, additional, Bueno Zamora, Hector, additional, Ferreiro Gutierrez, Jose Luis, additional, Almenar, Luis, additional, Ferreira Gonzalez, Ignacio, additional, Pascual Figal, Domingo A., additional, Almendro Delia, Manuel, additional, Jimenez Fernandez, Miriam, additional, Skeppholm, Mika, additional, Zedigh, Crister, additional, Angeras, Oskar, additional, Lauermann, Jorg, additional, Erlinge, David, additional, Gustafsson, Robin, additional, Mooe, Thomas, additional, Utreras, Alejandro, additional, James, Stefan, additional, Grimfjard, Per, additional, Pedrazzini, Giovanni, additional, Mach, Francois, additional, Fournier, Stephane, additional, Haegeli, Laurent, additional, Beer, Jurg H., additional, Leibundgut, Gregor, additional, Kobza, Richard, additional, Kaiser, Christoph, additional, Kunadian, Vijay, additional, Al-Lamee, Rasha, additional, Gorog, Diana, additional, Khan, Sohail, additional, Trevelyan, Jasper, additional, Toor, Iqbal, additional, Smith, James, additional, Purushottam, Bhaskar, additional, Treasure, Charles, additional, Arena, Frank, additional, Vedere, Amarnath, additional, Henderson, David, additional, Gilani, Syed, additional, Jones, Alonzo, additional, Carrillo-Jimenez, Rodolfo, additional, Gillespie, Eve, additional, Marhefka, Gregary, additional, Wang, David, additional, Olson, Charles, additional, Bloom, Stephen, additional, Iftikhar, Faizan, additional, Brabham, David, additional, McGinty, John, additional, Thompson, Charles, additional, Talano, James, additional, Ginete, Wilson, additional, Williams, Marcus, additional, Masud, Ali, additional, Ariani, Mehrdad, additional, Bitar, Fahed, additional, Wang, Thomas, additional, and Samuelson, Bradley, additional

Published
2022
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97. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction

Author

Solomon, Scott D., primary, McMurray, John J.V., additional, Claggett, Brian, additional, de Boer, Rudolf A., additional, DeMets, David, additional, Hernandez, Adrian F., additional, Inzucchi, Silvio E., additional, Kosiborod, Mikhail N., additional, Lam, Carolyn S.P., additional, Martinez, Felipe, additional, Shah, Sanjiv J., additional, Desai, Akshay S., additional, Jhund, Pardeep S., additional, Belohlavek, Jan, additional, Chiang, Chern-En, additional, Borleffs, C. Jan Willem, additional, Comin-Colet, Josep, additional, Dobreanu, Dan, additional, Drozdz, Jaroslaw, additional, Fang, James C., additional, Alcocer-Gamba, Marco Antonio, additional, Al Habeeb, Waleed, additional, Han, Yaling, additional, Cabrera Honorio, Jose Walter, additional, Janssens, Stefan P., additional, Katova, Tzvetana, additional, Kitakaze, Masafumi, additional, Merkely, Béla, additional, O’Meara, Eileen, additional, Saraiva, Jose Francisco Kerr, additional, Tereshchenko, Sergey N., additional, Thierer, Jorge, additional, Vaduganathan, Muthiah, additional, Vardeny, Orly, additional, Verma, Subodh, additional, Pham, Vinh Nguyen, additional, Wilderäng, Ulrica, additional, Zaozerska, Natalia, additional, Bachus, Erasmus, additional, Lindholm, Daniel, additional, Petersson, Magnus, additional, and Langkilde, Anna Maria, additional

Published
2022
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99. 468 Comparison of Subjects Enrolled in Large Animal Models and Human Clinical Trials Studying Post-Cardiac Arrest Interventions

Author

Jung, Woo Jin, Fumagalli, Francesca, Magliocca, Aurora, Persson, Olof, Vammen, Lauge, Szinovatz, Alexander, Tiba, Hakam, Weihs, Wolfgang, Mlcek, Mikulas, Hsu, Cindy, Sanderson, Thomas, Granfeldt, Asger, Belohlavek, Jan, Holzer, Michael, Tissier, Renaud, Ristagno, Guiseppe, Cha, Kyoung-Chul, Friberg, Hans, and Neumar, Robert

Published
2024
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