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53. A Case of Ralstonia pickettii Bloodstream Infection and the Growing Problem of Healthcare Associated Infections in Frail Older Adults

Author

Fiore, Francesca, primary, Cacciatore, Stefano, additional, Tupputi, Salvatore, additional, Agostino, Clara, additional, Montenero, Rossella, additional, Spaziani, Giovanni, additional, Elmi, Daniele, additional, Medei, Martina, additional, Antocicco, Manuela, additional, Mammarella, Federica, additional, Taddei, Eleonora, additional, Manes-Gravina, Ester, additional, Bernabei, Roberto, additional, and Landi, Francesco, additional

Published
2022
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54. Post-COVID-19 Psychiatric Symptoms in the Elderly: The Role of Gender and Resilience

Author

Janiri, Delfina, primary, Tosato, Matteo, additional, Simonetti, Alessio, additional, Montanari, Silvia, additional, Terenzi, Beatrice, additional, Catinari, Antonello, additional, De Mori, Lorenzo, additional, Ferrajoli, Gaspare Filippo, additional, Kotzalidis, Georgios D., additional, Landi, Francesco, additional, Bernabei, Roberto, additional, and Sani, Gabriele, additional

Published
2022
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55. The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: design and methods

Author

Landi, Francesco, Cesari, Matteo, Calvani, Riccardo, Cherubini, Antonio, Di Bari, Mauro, Bejuit, Raphael, Mshid, Jerome, Andrieu, Sandrine, Sinclair, Alan J., Sieber, Cornel C., Vellas, Bruno, Topinkova, Eva, Strandberg, Timo, Rodriguez-Manas, Leocadio, Lattanzio, Fabrizia, Pahor, Marco, Roubenoff, Ronenn, Cruz-Jentoft, Alfonso J., Bernabei, Roberto, Marzetti, Emanuele, and on behalf of the SPRINTT Consortium

Published
2017
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56. Sarcopenia: an overview

Author

Marzetti, Emanuele, Calvani, Riccardo, Tosato, Matteo, Cesari, Matteo, Di Bari, Mauro, Cherubini, Antonio, Collamati, Agnese, D’Angelo, Emanuela, Pahor, Marco, Bernabei, Roberto, Landi, Francesco, and on behalf of the SPRINTT Consortium

Published
2017
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57. Biomarkers for physical frailty and sarcopenia

Author

Calvani, Riccardo, Marini, Federico, Cesari, Matteo, Tosato, Matteo, Picca, Anna, Anker, Stefan D., von Haehling, Stephan, Miller, Ram R., Bernabei, Roberto, Landi, Francesco, Marzetti, Emanuele, and For the SPRINTT Consortium

Published
2017
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66. Neuropsychological Measures of Long COVID-19 Fog in Older Subjects

Author

Lauria, Alessandra, primary, Carfì, Angelo, additional, Benvenuto, Francesca, additional, Bramato, Giulia, additional, Ciciarello, Francesca, additional, Rocchi, Sara, additional, Rota, Elisabetta, additional, Salerno, Andrea, additional, Stella, Leonardo, additional, Tritto, Marcello, additional, Di Paola, Antonella, additional, Pais, Cristina, additional, Tosato, Matteo, additional, Janiri, Delfina, additional, Sani, Gabriele, additional, Pagano, Francesco Cosimo, additional, Fantoni, Massimo, additional, Bernabei, Roberto, additional, Landi, Francesco, additional, and Bizzarro, Alessandra, additional

Published
2022
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70. Relationship between frailty and drug use among nursing homes residents: results from the SHELTER study

Author

Villani, Emanuele Rocco, Vetrano, Davide Liborio, Liperoti, Rosa, Palmer, Katie, Denkinger, Michael, van der Roest, Henriëtte G, Bernabei, Roberto, Onder, Graziano, Liperoti, Rosa (ORCID:0000-0003-3740-1687), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Onder, Graziano (ORCID:0000-0003-3400-4491), Villani, Emanuele Rocco, Vetrano, Davide Liborio, Liperoti, Rosa, Palmer, Katie, Denkinger, Michael, van der Roest, Henriëtte G, Bernabei, Roberto, Onder, Graziano, Liperoti, Rosa (ORCID:0000-0003-3740-1687), Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Onder, Graziano (ORCID:0000-0003-3400-4491)

Abstract

Background 1.5-8% of older adults live in nursing homes (NHs), presenting a high prevalence of frailty and polypharmacy. Aims To investigate the association of frailty with polypharmacy and drug prescription patterns in a sample of European Nursing Home (NH) residents. Methods Cross-sectional study based on the data from the Services and Health for Elderly in Long TERm care (SHELTER) study. 4121 NH residents in Europe and Israel. Residents' clinical, cognitive, social, and physical status were evaluated with the InterRAI LTCF tool, which allows comprehensive, standardized evaluation of persons living in NH. Polypharmacy and hyperpolypharmacy were defined as the concurrent use of >= 5 and >= 10 medications. Frailty was defined according to the FRAIL-NH scale. Results Of 4121 participants, 46.6% were frail (mean age 84.6 +/- 9.2 years; 76.4% female). Polypharmacy and hyperpolypharmacy were associated with a lower likelihood of frailty (Odds Ratio = 0.72; 95% CI = 0.59-0.87 and OR = 0.75; 95% CI = 0.60-0.94, respectively). Patterns of drug prescriptions were different between frail and non-frail residents. Symptomatic drugs (laxatives, paracetamol, and opioids) were more frequently prescribed among frail residents, while preventive drugs (bisphosphonates, vitamin D, and acetylsalicylic acid) were more frequently prescribed among non-frail residents. Conclusions Frailty is associated with less polypharmacy and with higher prevalence of symptomatic drugs use among NH residents. Further studies are needed to define appropriateness of drug prescription in frail individuals.

Published
2021

71. Predictive Factors for a New Positive Nasopharyngeal Swab Among Patients Recovered From COVID-19

Author

Landi, Francesco, Carfì, Angelo, Benvenuto, Francesca, Brandi, Vincenzo, Ciciarello, Francesca, Lo Monaco, Maria Rita, Martone, Anna Maria, Napolitano, Carmen, Pagano, Francesco Cosimo, Paglionico, Annamaria, Petricca, Luca, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea Maria, Tritto, Marcello, Gremese, Elisa, Bernabei, Roberto, Landi, Francesco (ORCID:0000-0002-3472-1389), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Pagano, Francesco, Salerno, Andrea, Gremese, Elisa (ORCID:0000-0002-2248-1058), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Landi, Francesco, Carfì, Angelo, Benvenuto, Francesca, Brandi, Vincenzo, Ciciarello, Francesca, Lo Monaco, Maria Rita, Martone, Anna Maria, Napolitano, Carmen, Pagano, Francesco Cosimo, Paglionico, Annamaria, Petricca, Luca, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea Maria, Tritto, Marcello, Gremese, Elisa, Bernabei, Roberto, Landi, Francesco (ORCID:0000-0002-3472-1389), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Pagano, Francesco, Salerno, Andrea, Gremese, Elisa (ORCID:0000-0002-2248-1058), and Bernabei, Roberto (ORCID:0000-0002-9197-004X)

Abstract

Introduction: As an emerging infectious disease, the clinical and virologic course of COVID-19 requires better investigation. The aim of this study is to identify the potential risk factors associated with persistent positive nasopharyngeal swab real-time reverse transcription-polymerase chain reaction tests in a large sample of patients who recovered from COVID-19.Methods: After the acute phase of SARS-CoV-2 epidemic infection, the Fondazione Policlinico A. Gemelli IRCSS of Rome established a post-acute care service for patients discharged from the hospital and recovered from COVID-19. Between April 21 and May 21, 2020, a total of 137 individuals who officially recovered from COVID-19 were enrolled in this study. All patients were tested for the SARS-CoV-2 virus with nucleic acid RT-PCR tests. Analysis was conducted in June 2020.Results: Of the 131 patients who repeated the nasopharyngeal swab, 22 patients (16.7%) tested positive again. Some symptoms such as fatigue (51%), dyspnea (44%), and coughing (17%) were still present in a significant percentage of the patients, with no difference between patients with a negative test and those who tested positive. The likelihood of testing positive for SARS-CoV-2 infection was significantly higher among participants with persistent sore throat (prevalence ratio=6.50, 95% CI=1.38, 30.6) and symptoms of rhinitis (prevalence ratio=3.72, 95% CI=1.10, 12.5).Conclusions: This study is the first to provide a given rate of patients (16.7%) who test positive on RT-PCR test for SARS-CoV-2 nucleic acid after recovering from COVID-19. These findings suggest that a significant proportion of patients who have recovered from COVID-19 still could be potential carriers of the virus. In particular, if patients continue to have symptoms related to COVID-19, such as sore throat and rhinitis, it is reasonable to be cautious by avoiding close contact, wearing a face mask, and possibly repeating a nasopharyngeal swab. (C) 2020 American Journal of

Published
2021

72. Association between frailty and ischemic heart disease: a systematic review and meta-analysis

Author

Liperoti, Rosa, Vetrano, Davide L, Palmer, Katie, Targowski, Tomasz, Cipriani, Maria Camilla, Lo Monaco, Maria Rita, Giovannini, Silvia, Acampora, Nicola, Villani, Emanuele Rocco, Bernabei, Roberto, Onder, Graziano, Liperoti, Rosa (ORCID:0000-0003-3740-1687), Cipriani, Maria C, Lo Monaco, Maria R (ORCID:0000-0002-1457-7981), Giovannini, Silvia (ORCID:0000-0001-9125-752X), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Onder, Graziano (ORCID:0000-0003-3400-4491), Liperoti, Rosa, Vetrano, Davide L, Palmer, Katie, Targowski, Tomasz, Cipriani, Maria Camilla, Lo Monaco, Maria Rita, Giovannini, Silvia, Acampora, Nicola, Villani, Emanuele Rocco, Bernabei, Roberto, Onder, Graziano, Liperoti, Rosa (ORCID:0000-0003-3740-1687), Cipriani, Maria C, Lo Monaco, Maria R (ORCID:0000-0002-1457-7981), Giovannini, Silvia (ORCID:0000-0001-9125-752X), Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Onder, Graziano (ORCID:0000-0003-3400-4491)

Abstract

Background Frailty is increasingly reported among older adults with cardiovascular diseases and it has been demonstrated to increase negative health outcomes and mortality. To date, no systematic review of the evidence is available regarding the association between frailty and ischemic heart disease (IHD). We performed a systematic review of literature and a meta-analysis to assess the association between frailty and IHD. Methods We selected all the studies that provided information on the association between frailty and IHD, regardless of the study setting, study design, or definition of IHD and frailty. PubMed, Web of Science and Embase were searched for relevant papers. Studies that adopted the Fried definition for frailty were included in the meta-analyses. For each measure of interest (proportions and estimates of associations), a meta-analysis was performed if at least three studies used the same definition of frailty. Pooled estimates were obtained through random effect models and Mantel-Haenszel weighting. Results Thirty-seven studies were included. Of these, 22 adopted the Fried criteria to define frailty and provided estimates of prevalence and therefore they were included in meta-analyses. The pooled prevalence of IHD in frail individuals was 17% (95% Confidence Interval [95%CI] 11-23%) and the pooled prevalence of frailty in individuals with IHD was 19% (95% CI 15-24%). The prevalence of frailty among IHD patients ranged from 4 to 61%. Insufficient data were found to assess longitudinal association between frailty and IHD. Conclusions Frailty is quite common in older persons with IHD. The identification of frailty among older adults with IHD should be considered relevant to provide individualized strategies of cardiovascular prevention and care. Further research should specifically explore the association between frailty and IHD and investigate the potential common biological ground.

Published
2021

73. A machine-learning parsimonious multivariable predictive model of mortality risk in patients with Covid-19

Author

Murri, Rita, Lenkowicz, Jacopo, Masciocchi, Carlotta, Iacomini, Chiara, Fantoni, Massimo, Damiani, Andrea, Marchetti, Antonio, Sergi, Paolo Domenico Angelo, Arcuri, Giovanni, Cesario, Alfredo, Patarnello, Stefano, Antonelli, Massimo, Bellantone, Rocco Domenico Alfonso, Bernabei, Roberto, Boccia, Stefania, Calabresi, Paolo, Cambieri, Andrea, Cauda, Roberto, Colosimo, Cesare, Crea, Filippo, De Maria Marchiano, Ruggero, De Stefano, Valerio, Franceschi, Francesco, Gasbarrini, Antonio, Parolini, Ornella, Richeldi, Luca, Sanguinetti, Maurizio, Urbani, Andrea, Zega, Maurizio, Scambia, Giovanni, Valentini, Vincenzo, Armuzzi, Alessandro, Barba, Marta, Baroni, Silvia, Bellesi, Silvia, Bentivoglio, Annarita, Biasucci, Luigi Marzio, Biscetti, Federico, Candelli, Marcello, Capalbo, Gennaro, Cattani Franchi, Paola, Chiusolo, Patrizia, Cingolani, Antonella, Corbo, Giuseppe Maria, Covino, Marcello, Cozzolino, Angela Maria, D’Alfonso, Marilena, De Angelis, Giulia, De Pascale, Gennaro, Frisullo, Giovanni, Gabrielli, Maurizio, Gambassi, Giovanni, Garcovich, Matteo, Gremese, Elisa, Grieco, Domenico Luca, Iaconelli, Amerigo, Iorio, Raffaele, Landi, Francesco, Larici, Annarita, Liuzzo, Giovanna, Maviglia, Riccardo, Miele, Luca, Montalto, Massimo, Natale, Luigi, Nicolotti, Nicola, Ojetti, Veronica, Pompili, Maurizio, Posteraro, Brunella, Rapaccini, Gianni, Rinaldi, Riccardo, Rossi, Elena, Santoliquido, Angelo, Sica, Simona, Tamburrini, Enrica, Teofili, Luciana, Testa, Antonia Carla, Tosoni, Alberto, Trani, Carlo, Varone, Francesco, Zileri Dal Verme, Lorenzo, Null, Null, Murri, Rita (ORCID:0000-0003-4263-7854), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Cesario, Alfredo (ORCID:0000-0003-4687-0709), Antonelli, Massimo (ORCID:0000-0003-3007-1670), Bellantone, Rocco (ORCID:0000-0002-0844-3469), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Boccia, Stefania (ORCID:0000-0002-1864-749X), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Cauda, Roberto (ORCID:0000-0002-1498-4229), Colosimo, Cesare (ORCID:0000-0003-3800-3648), Crea, Filippo (ORCID:0000-0001-9404-8846), De Maria, Ruggero (ORCID:0000-0003-2255-0583), De Stefano, Valerio (ORCID:0000-0002-5178-5827), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Parolini, Ornella (ORCID:0000-0002-5211-6430), Richeldi, Luca (ORCID:0000-0001-8594-1448), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Zega, Maurizio (ORCID:0000-0002-7821-2615), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), Barba, Marta (ORCID:0000-0001-6084-7666), Baroni, Silvia (ORCID:0000-0002-3410-2617), Biasucci, Luigi Marzio (ORCID:0000-0002-6921-6497), Biscetti, Federico (ORCID:0000-0001-7449-657X), Candelli, Marcello (ORCID:0000-0001-8443-7880), Cattani, Paola (ORCID:0000-0003-4678-4763), Chiusolo, Patrizia (ORCID:0000-0002-1355-1587), Cingolani, Antonella (ORCID:0000-0002-3793-2755), Corbo, Giuseppe (ORCID:0000-0002-8104-4659), Covino, Marcello (ORCID:0000-0002-6709-2531), De Angelis, Giulia (ORCID:0000-0002-7087-7399), De Pascale, Gennaro (ORCID:0000-0002-8255-0676), Gambassi, Giovanni (ORCID:0000-0002-7030-9359), Gremese, Elisa (ORCID:0000-0002-2248-1058), Grieco, Domenico Luca (ORCID:0000-0002-4557-6308), Iorio, Raffaele (ORCID:0000-0002-6270-0956), Landi, Francesco (ORCID:0000-0002-3472-1389), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Miele, Luca (ORCID:0000-0003-3464-0068), Montalto, Massimo (ORCID:0000-0001-8819-3684), Natale, Luigi (ORCID:0000-0002-7949-5119), Ojetti, Veronica (ORCID:0000-0002-8953-0707), Pompili, Maurizio (ORCID:0000-0001-6699-7980), Posteraro, Brunella (ORCID:0000-0002-1663-7546), Rossi, Elena (ORCID:0000-0002-7572-9379), Santoliquido, Angelo (ORCID:0000-0003-1539-4017), Tamburrini, Enrica (ORCID:0000-0003-4930-426X), Teofili, Luciana (ORCID:0000-0002-7214-1561), Testa, Antonia (ORCID:0000-0003-2217-8726), Trani, Carlo (ORCID:0000-0001-9777-013X), Verme, Lorenzo Zileri Dal, Murri, Rita, Lenkowicz, Jacopo, Masciocchi, Carlotta, Iacomini, Chiara, Fantoni, Massimo, Damiani, Andrea, Marchetti, Antonio, Sergi, Paolo Domenico Angelo, Arcuri, Giovanni, Cesario, Alfredo, Patarnello, Stefano, Antonelli, Massimo, Bellantone, Rocco Domenico Alfonso, Bernabei, Roberto, Boccia, Stefania, Calabresi, Paolo, Cambieri, Andrea, Cauda, Roberto, Colosimo, Cesare, Crea, Filippo, De Maria Marchiano, Ruggero, De Stefano, Valerio, Franceschi, Francesco, Gasbarrini, Antonio, Parolini, Ornella, Richeldi, Luca, Sanguinetti, Maurizio, Urbani, Andrea, Zega, Maurizio, Scambia, Giovanni, Valentini, Vincenzo, Armuzzi, Alessandro, Barba, Marta, Baroni, Silvia, Bellesi, Silvia, Bentivoglio, Annarita, Biasucci, Luigi Marzio, Biscetti, Federico, Candelli, Marcello, Capalbo, Gennaro, Cattani Franchi, Paola, Chiusolo, Patrizia, Cingolani, Antonella, Corbo, Giuseppe Maria, Covino, Marcello, Cozzolino, Angela Maria, D’Alfonso, Marilena, De Angelis, Giulia, De Pascale, Gennaro, Frisullo, Giovanni, Gabrielli, Maurizio, Gambassi, Giovanni, Garcovich, Matteo, Gremese, Elisa, Grieco, Domenico Luca, Iaconelli, Amerigo, Iorio, Raffaele, Landi, Francesco, Larici, Annarita, Liuzzo, Giovanna, Maviglia, Riccardo, Miele, Luca, Montalto, Massimo, Natale, Luigi, Nicolotti, Nicola, Ojetti, Veronica, Pompili, Maurizio, Posteraro, Brunella, Rapaccini, Gianni, Rinaldi, Riccardo, Rossi, Elena, Santoliquido, Angelo, Sica, Simona, Tamburrini, Enrica, Teofili, Luciana, Testa, Antonia Carla, Tosoni, Alberto, Trani, Carlo, Varone, Francesco, Zileri Dal Verme, Lorenzo, Null, Null, Murri, Rita (ORCID:0000-0003-4263-7854), Fantoni, Massimo (ORCID:0000-0001-6913-8460), Cesario, Alfredo (ORCID:0000-0003-4687-0709), Antonelli, Massimo (ORCID:0000-0003-3007-1670), Bellantone, Rocco (ORCID:0000-0002-0844-3469), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Boccia, Stefania (ORCID:0000-0002-1864-749X), Calabresi, Paolo (ORCID:0000-0003-0326-5509), Cauda, Roberto (ORCID:0000-0002-1498-4229), Colosimo, Cesare (ORCID:0000-0003-3800-3648), Crea, Filippo (ORCID:0000-0001-9404-8846), De Maria, Ruggero (ORCID:0000-0003-2255-0583), De Stefano, Valerio (ORCID:0000-0002-5178-5827), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Parolini, Ornella (ORCID:0000-0002-5211-6430), Richeldi, Luca (ORCID:0000-0001-8594-1448), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Zega, Maurizio (ORCID:0000-0002-7821-2615), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Valentini, Vincenzo (ORCID:0000-0003-4637-6487), Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), Barba, Marta (ORCID:0000-0001-6084-7666), Baroni, Silvia (ORCID:0000-0002-3410-2617), Biasucci, Luigi Marzio (ORCID:0000-0002-6921-6497), Biscetti, Federico (ORCID:0000-0001-7449-657X), Candelli, Marcello (ORCID:0000-0001-8443-7880), Cattani, Paola (ORCID:0000-0003-4678-4763), Chiusolo, Patrizia (ORCID:0000-0002-1355-1587), Cingolani, Antonella (ORCID:0000-0002-3793-2755), Corbo, Giuseppe (ORCID:0000-0002-8104-4659), Covino, Marcello (ORCID:0000-0002-6709-2531), De Angelis, Giulia (ORCID:0000-0002-7087-7399), De Pascale, Gennaro (ORCID:0000-0002-8255-0676), Gambassi, Giovanni (ORCID:0000-0002-7030-9359), Gremese, Elisa (ORCID:0000-0002-2248-1058), Grieco, Domenico Luca (ORCID:0000-0002-4557-6308), Iorio, Raffaele (ORCID:0000-0002-6270-0956), Landi, Francesco (ORCID:0000-0002-3472-1389), Liuzzo, Giovanna (ORCID:0000-0002-5714-0907), Miele, Luca (ORCID:0000-0003-3464-0068), Montalto, Massimo (ORCID:0000-0001-8819-3684), Natale, Luigi (ORCID:0000-0002-7949-5119), Ojetti, Veronica (ORCID:0000-0002-8953-0707), Pompili, Maurizio (ORCID:0000-0001-6699-7980), Posteraro, Brunella (ORCID:0000-0002-1663-7546), Rossi, Elena (ORCID:0000-0002-7572-9379), Santoliquido, Angelo (ORCID:0000-0003-1539-4017), Tamburrini, Enrica (ORCID:0000-0003-4930-426X), Teofili, Luciana (ORCID:0000-0002-7214-1561), Testa, Antonia (ORCID:0000-0003-2217-8726), Trani, Carlo (ORCID:0000-0001-9777-013X), and Verme, Lorenzo Zileri Dal

Abstract

The COVID-19 pandemic is impressively challenging the healthcare system. Several prognostic models have been validated but few of them are implemented in daily practice. The objective of the study was to validate a machine-learning risk prediction model using easy-to-obtain parameters to help to identify patients with COVID-19 who are at higher risk of death. The training cohort included all patients admitted to Fondazione Policlinico Gemelli with COVID-19 from March 5, 2020, to November 5, 2020. Afterward, the model was tested on all patients admitted to the same hospital with COVID-19 from November 6, 2020, to February 5, 2021. The primary outcome was in-hospital case-fatality risk. The out-of-sample performance of the model was estimated from the training set in terms of Area under the Receiving Operator Curve (AUROC) and classification matrix statistics by averaging the results of fivefold cross validation repeated 3-times and comparing the results with those obtained on the test set. An explanation analysis of the model, based on the SHapley Additive exPlanations (SHAP), is also presented. To assess the subsequent time evolution, the change in paO2/FiO2 (P/F) at 48 h after the baseline measurement was plotted against its baseline value. Among the 921 patients included in the training cohort, 120 died (13%). Variables selected for the model were age, platelet count, SpO2, blood urea nitrogen (BUN), hemoglobin, C-reactive protein, neutrophil count, and sodium. The results of the fivefold cross-validation repeated 3-times gave AUROC of 0.87, and statistics of the classification matrix to the Youden index as follows: sensitivity 0.840, specificity 0.774, negative predictive value 0.971. Then, the model was tested on a new population (n=1463) in which the case-fatality rate was 22.6%. The test model showed AUROC 0.818, sensitivity 0.813, specificity 0.650, negative predictive value 0.922. Considering the first quartile of the predicted risk score (low-risk score gro

Published
2021

76. Neuropsychological measures of post-COVID-19 cognitive status.

Author

Lauria, Alessandra, Carfì, Angelo, Benvenuto, Francesca, Bramato, Giulia, Ciciarello, Francesca, Rocchi, Sara, Rota, Elisabetta, Salerno, Andrea, Stella, Leonardo, Tritto, Marcello, Di Paola, Antonella, Pais, Cristina, Tosato, Matteo, Janiri, Delfina, Sani, Gabriele, Monaco, Rita Lo, Pagano, Francesco C., Fantoni, Massimo, Bernabei, Roberto, and Landi, Francesco

Subjects
TRAIL Making Test, COVID-19 pandemic, NEUROPSYCHOLOGICAL tests, MEMORY span, PSYCHOLOGICAL stress, MINI-Mental State Examination
Abstract

Background: COVID-19 may result in persistent symptoms in the post-acute phase, including cognitive and neurological ones. The aim of this study is to investigate the cognitive and neurological features of patients with a confirmed diagnosis of COVID-19 evaluated in the post-acute phase through a direct neuropsychological evaluation. Methods: Individuals recovering from COVID-19 were assessed in an out-patient practice with a complete neurological evaluation and neuropsychological tests (Mini-Mental State Examination; Rey Auditory Verbal Test, Multiple Feature Target Cancellation Test, Trial Making Test, Digit Span Forward and Backward, and Frontal Assessment Battery). Pre- and post-COVID-19 global and mental health status was assessed along with the history of the acute phase of infection. Post-COVID-19 cognitive status was modeled by combining persistent self-reported COVID-related cognitive symptoms and pathologic neuropsychological tests. Results: A total of 406 individuals (average age 54.5 ± 15.1 years, 45.1% women) were assessed on average at 97.8 ± 48.0 days since symptom onset. Persistent self-reported neurological symptoms were found in the areas of sleep (32%), attention (31%), and memory (22%). The MMSE mean score was 28.6. In total, 84 subjects (20.7%) achieved pathologic neuropsychological test results. A high prevalence of failed tests was found in digit span backward (18.7%), trail making (26.6%), and frontal assessment battery (10.9%). Cognitive status was associated with a number of factors including cardiovascular disease history, persistent fatigue, female sex, age, anxiety, and mental health stress. Conclusion: COVID-19 is capable of eliciting persistent measurable neurocognitive alterations particularly relevant in the areas of attention and working memory. These neurocognitive disorders have been associated with some potentially treatable factors and others thatmay stratify risk at an early stage. [ABSTRACT FROM AUTHOR]

Published
2023
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81. Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project)

Author

Bernabei, Roberto, primary, Landi, Francesco, additional, Calvani, Riccardo, additional, Cesari, Matteo, additional, Del Signore, Susanna, additional, Anker, Stefan D, additional, Bejuit, Raphael, additional, Bordes, Philippe, additional, Cherubini, Antonio, additional, Cruz-Jentoft, Alfonso J, additional, Di Bari, Mauro, additional, Friede, Tim, additional, Gorostiaga Ayestarán, Carmen, additional, Goyeau, Harmonie, additional, Jónsson, Pálmi V, additional, Kashiwa, Makoto, additional, Lattanzio, Fabrizia, additional, Maggio, Marcello, additional, Mariotti, Luca, additional, Miller, Ram R, additional, Rodriguez-Mañas, Leocadio, additional, Roller-Wirnsberger, Regina, additional, Rýznarová, Ingrid, additional, Scholpp, Joachim, additional, Schols, Annemie M W J, additional, Sieber, Cornel C, additional, Sinclair, Alan J, additional, Skalska, Anna, additional, Strandberg, Timo, additional, Tchalla, Achille, additional, Topinková, Eva, additional, Tosato, Matteo, additional, Vellas, Bruno, additional, von Haehling, Stephan, additional, Pahor, Marco, additional, Roubenoff, Ronenn, additional, and Marzetti, Emanuele, additional

Published
2022
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84. Positive RT-PCR nasopharyngeal swab in patients recovered from COVID-19 disease: When does quarantine really end?

Author

Landi, Francesco, Gremese, Elisa, Rota, Elisabetta, Carfi', Angelo, Benvenuto, Francesca, Ciciarello, Francesca, Lo Monaco, Maria Rita, Martone, Anna Maria, Pagano, Francesco Cosimo, Paglionico, Annamaria, Petricca, Luca, Rocchi, Sara, Tritto, Marcello, Sanguinetti, Maurizio, Bernabei, Roberto, Landi, Francesco (ORCID:0000-0002-3472-1389), Gremese, Elisa (ORCID:0000-0002-2248-1058), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Pagano, Francesco, Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Landi, Francesco, Gremese, Elisa, Rota, Elisabetta, Carfi', Angelo, Benvenuto, Francesca, Ciciarello, Francesca, Lo Monaco, Maria Rita, Martone, Anna Maria, Pagano, Francesco Cosimo, Paglionico, Annamaria, Petricca, Luca, Rocchi, Sara, Tritto, Marcello, Sanguinetti, Maurizio, Bernabei, Roberto, Landi, Francesco (ORCID:0000-0002-3472-1389), Gremese, Elisa (ORCID:0000-0002-2248-1058), Lo Monaco, Maria Rita (ORCID:0000-0002-1457-7981), Pagano, Francesco, Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), and Bernabei, Roberto (ORCID:0000-0002-9197-004X)

Abstract

No abstract available

Published
2020

85. Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson's Disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) Study

Author

Picca, Anna, Guerra, Flora, Calvani, Riccardo, Marini, Federico, Biancolillo, Alessandra, Landi, Giovanni, Beli, Raffaella, Landi, Francesco, Bernabei, Roberto, Bentivoglio, Anna Rita, Lo Monaco, Maria Rita, Bucci, Cecilia, Marzetti, Emanuele, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Landi, Francesco (ORCID:0000-0002-3472-1389), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Monaco, Maria Rita Lo (ORCID:0000-0002-1457-7981), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Picca, Anna, Guerra, Flora, Calvani, Riccardo, Marini, Federico, Biancolillo, Alessandra, Landi, Giovanni, Beli, Raffaella, Landi, Francesco, Bernabei, Roberto, Bentivoglio, Anna Rita, Lo Monaco, Maria Rita, Bucci, Cecilia, Marzetti, Emanuele, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Landi, Francesco (ORCID:0000-0002-3472-1389), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Bentivoglio, Anna Rita (ORCID:0000-0002-9663-095X), Monaco, Maria Rita Lo (ORCID:0000-0002-1457-7981), and Marzetti, Emanuele (ORCID:0000-0001-9567-6983)

Abstract

Systemic inflammation and mitochondrial dysfunction are involved in neurodegeneration in Parkinson's disease (PD). Extracellular vesicle (EV) trafficking may link inflammation and mitochondrial dysfunction. In the present study, circulating small EVs (sEVs) from 16 older adults with PD and 12 non-PD controls were purified and characterized. A panel of serum inflammatory biomolecules was measured by multiplex immunoassay. Protein levels of three tetraspanins (CD9, CD63, and CD81) and selected mitochondrial markers (adenosine triphosphate 5A (ATP5A), mitochondrial cytochrome C oxidase subunit I (MTCOI), nicotinamide adenine dinucleotide reduced form (NADH):ubiquinone oxidoreductase subunit B8 (NDUFB8), NADH:ubiquinone oxidoreductase subunit S3 (NDUFS3), succinate dehydrogenase complex iron sulfur subunit B (SDHB), and ubiquinol-cytochrome C reductase core protein 2 (UQCRC2)) were quantified in purified sEVs by immunoblotting. Relative to controls, PD participants showed a greater amount of circulating sEVs. Levels of CD9 and CD63 were lower in the sEV fraction of PD participants, whereas those of CD81 were similar between groups. Lower levels of ATP5A, NDUFS3, and SDHB were detected in sEVs from PD participants. No signal was retrieved for UQCRC2, MTCOI, or NDUFB8 in either participant group. To identify a molecular signature in circulating sEVs in relationship to systemic inflammation, a low level-fused (multi-platform) partial least squares discriminant analysis was applied. The model correctly classified 94.2% +/- 6.1% PD participants and 66.7% +/- 5.4% controls, and identified seven biomolecules as relevant (CD9, NDUFS3, C-reactive protein, fibroblast growth factor 21, interleukin 9, macrophage inflammatory protein 1 beta, and tumor necrosis factor alpha). In conclusion, a mitochondrial signature was identified in circulating sEVs from older adults with PD, in association with a specific inflammatory profile. In-depth characterization of sEV trafficking may allow

Published
2020

86. Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease

Author

Picca, Anna, Guerra, Flora, Calvani, Riccardo, Coelho-Junior, Hélio José, Bossola, Maurizio, Landi, Francesco, Bernabei, Roberto, Bucci, Cecilia, Marzetti, Emanuele, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Bossola, Maurizio (ORCID:0000-0003-1627-0235), Landi, Francesco (ORCID:0000-0002-3472-1389), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Picca, Anna, Guerra, Flora, Calvani, Riccardo, Coelho-Junior, Hélio José, Bossola, Maurizio, Landi, Francesco, Bernabei, Roberto, Bucci, Cecilia, Marzetti, Emanuele, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Bossola, Maurizio (ORCID:0000-0003-1627-0235), Landi, Francesco (ORCID:0000-0002-3472-1389), Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Marzetti, Emanuele (ORCID:0000-0001-9567-6983)

Abstract

Mitochondria are intracellular organelles involved in a myriad of activities. To safeguard their vital functions, mitochondrial quality control (MQC) systems are in place to support organelle plasticity as well as physical and functional connections with other cellular compartments. In particular, mitochondrial interactions with the endosomal compartment support the shuttle of ions and metabolites across organelles, while those with lysosomes ensure the recycling of obsolete materials. The extrusion of mitochondrial components via the generation and release of mitochondrial-derived vesicles (MDVs) has recently been described. MDV trafficking is now included among MQC pathways, possibly operating via mitochondrial-lysosomal contacts. Since mitochondrial dysfunction is acknowledged as a hallmark of aging and a major pathogenic factor of multiple age-associated conditions, the analysis of MDVs and, more generally, of extracellular vesicles (EVs) is recognized as a valuable research tool. The dissection of EV trafficking may help unravel new pathophysiological pathways of aging and diseases as well as novel biomarkers to be used in research and clinical settings. Here, we discuss (1) MQC pathways with a focus on mitophagy and MDV generation; (2) changes of MQC pathways during aging and their contribution to inflamm-aging and progeroid conditions; and (3) the relevance of MQC failure to several disorders, including neurodegenerative conditions (i.e., Parkinson's disease, Alzheimer's disease) and cardiovascular disease.

Published
2020

87. Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults

Author

Picca, Anna, Saini, Sunil K, Mankowski, Robert T, Kamenov, George, Anton, Stephen D, Manini, Todd M, Buford, Thomas W, Wohlgemuth, Stephanie E, Xiao, Rui, Calvani, Riccardo, Coelho-Júnior, Hélio José, Landi, Francesco, Bernabei, Roberto, Hood, David A, Marzetti, Emanuele, Leeuwenburgh, Christiaan, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Landi, Francesco (ORCID:0000-0002-3472-1389), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Picca, Anna, Saini, Sunil K, Mankowski, Robert T, Kamenov, George, Anton, Stephen D, Manini, Todd M, Buford, Thomas W, Wohlgemuth, Stephanie E, Xiao, Rui, Calvani, Riccardo, Coelho-Júnior, Hélio José, Landi, Francesco, Bernabei, Roberto, Hood, David A, Marzetti, Emanuele, Leeuwenburgh, Christiaan, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Landi, Francesco (ORCID:0000-0002-3472-1389), Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Marzetti, Emanuele (ORCID:0000-0001-9567-6983)

Abstract

Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial-iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle biopsies obtained from young and older adults. The expression of key proteins of mitochondrial quality control (MQC) and the abundance of the mitochondrial DNA common deletion (mtDNA4977) were also assessed. An inverse association was found between total Fe and the heavier Fe isotope (56Fe), indicating an increase in labile Fe abundance in cells with greater Fe content. The highest levels of labile Fe were detected in old participants with a Short Physical Performance Battery (SPPB) score ≤ 7 (low-functioning, LF). Protein levels of mitoferrin and frataxin were, respectively, higher and lower in the LF group relative to young participants and older adults with SPPB scores ≥ 11 (high-functioning, HF). The mtDNA4977 relative abundance was greater in old than in young participants, regardless of SPPB category. Higher protein levels of Pink1 were detected in LF participants compared with young and HF groups. Finally, the ratio between lipidated and non-lipidated microtubule-associated protein 1A/1B-light chain 3 (i.e., LC3B II/I), as well as p62 protein expression was lower in old participants regardless of SPPB scores. Our findings indicate that cellular and mitochondrial Fe homeostasis is perturbed in the aged muscle (especially in LF older adults), as reflected by altered levels of mitoferrin and frataxin, which, together with MQC derangements, might contribute to loss of mtDNA stability.

Published
2020

88. Inter-Organelle Membrane Contact Sites and Mitochondrial Quality Control during Aging: A Geroscience View

Author

Picca, Anna, Calvani, Riccardo, Coelho-Junior, Hélio José, Landi, Francesco, Bernabei, Roberto, Marzetti, Emanuele, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Landi, Francesco (ORCID:0000-0002-3472-1389), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Picca, Anna, Calvani, Riccardo, Coelho-Junior, Hélio José, Landi, Francesco, Bernabei, Roberto, Marzetti, Emanuele, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Landi, Francesco (ORCID:0000-0002-3472-1389), Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Marzetti, Emanuele (ORCID:0000-0001-9567-6983)

Abstract

Mitochondrial dysfunction and failing mitochondrial quality control (MQC) are major determinants of aging. Far from being standalone organelles, mitochondria are intricately related with cellular other compartments, including lysosomes. The intimate relationship between mitochondria and lysosomes is reflected by the fact that lysosomal degradation of dysfunctional mitochondria is the final step of mitophagy. Inter-organelle membrane contact sites also allow bidirectional communication between mitochondria and lysosomes as part of nondegradative pathways. This interaction establishes a functional unit that regulates metabolic signaling, mitochondrial dynamics, and, hence, MQC. Contacts of mitochondria with the endoplasmic reticulum (ER) have also been described. ER-mitochondrial interactions are relevant to Ca2+ homeostasis, transfer of phospholipid precursors to mitochondria, and integration of apoptotic signaling. Many proteins involved in mitochondrial contact sites with other organelles also participate to degradative MQC pathways. Hence, a comprehensive assessment of mitochondrial dysfunction during aging requires a thorough evaluation of degradative and nondegradative inter-organelle pathways. Here, we present a geroscience overview on (1) degradative MQC pathways, (2) nondegradative processes involving inter-organelle tethering, (3) age-related changes in inter-organelle degradative and nondegradative pathways, and (4) relevance of MQC failure to inflammaging and age-related conditions, with a focus on Parkinson's disease as a prototypical geroscience condition.

Published
2020

89. Protein-Related Dietary Parameters and Frailty Status in Older Community-Dwellers across Different Frailty Instruments

Author

Coelho-Júnior, Hélio J, Calvani, Riccardo, Picca, Anna, Gonçalves, Ivan O, Landi, Francesco, Bernabei, Roberto, Cesari, Matteo, Uchida, Marco C, Marzetti, Emanuele, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Landi, Francesco (ORCID:0000-0002-3472-1389), Bernabei, Roberto (ORCID:0000-0002-9197-004X), Marzetti, Emanuele (ORCID:0000-0001-9567-6983), Coelho-Júnior, Hélio J, Calvani, Riccardo, Picca, Anna, Gonçalves, Ivan O, Landi, Francesco, Bernabei, Roberto, Cesari, Matteo, Uchida, Marco C, Marzetti, Emanuele, Calvani, Riccardo (ORCID:0000-0001-5472-2365), Landi, Francesco (ORCID:0000-0002-3472-1389), Bernabei, Roberto (ORCID:0000-0002-9197-004X), and Marzetti, Emanuele (ORCID:0000-0001-9567-6983)

Abstract

The present study investigated the associations between frailty status and (a) daily protein intake, (b) daily body weight-adjusted protein intake, (c) branched-chain amino acid (BCAA) consumption, (d) evenness of protein distribution across main meals, (e) number of daily meals providing at least 30 g of protein, and (f) number of daily meals providing at least 0.4 g protein/kg of body weight in community-dwelling older adults. The relationship between frailty status and protein-related dietary parameters was explored across different frailty assessment tools. Two hundred older adults were enrolled in the study. Participant frailty status was determined according to a modified Fried's frailty phenotype (mFP), the FRAIL scale, and the Study of Osteoporotic Fracture (SOF) index. Diet was assessed by 24-h dietary recall, while diet composition was estimated using a nutritional software. A frailty instrument-dependent relationship was observed between frailty status and protein-related dietary parameters. Protein consumption was associated with frailty status only in participants identified as frail according to the mFP. In addition, protein and BCAA intake was found to be greater in robust and pre-frail participants relative to their frail counterparts. Our findings suggest that the association between frailty and protein-related dietary parameters is tool dependent. Specifically, protein and BCAA consumption appears to be lower only in older adults identified as frail by the mFP.

Published
2020

92. Fatigue in Covid-19 survivors: The potential impact of a nutritional supplement on muscle strength and function

Author

Galluzzo, Vincenzo, Zazzara, Maria Beatrice, Ciciarello, Francesca, Savera, Giulia, Pais, C., Calvani, Riccardo, Picca, A., Marzetti, Emanuele, Landi, Francesco, Tosato, Matteo, Steering, Committee, Gremese, Elisa, Coordination, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Field, Investigator, Gastroenterology, Team, Porcari, Serena, Settanni, Carlo Romano, Geriatric, Team, Benvenuto, F., Bramato, Giulia, Brandi, Vincenzo, Carfi, A., Fabrizi, Sofia, Lo Monaco, Maria Rita, Martone, Anna Maria, Napolitano, C., Pagano, Francesco Cosimo, Rocchi, Sara, Rota, E., Salerno, Andrea Maria, Tritto, M., Catalano, Lucio, Damiano, Francesco Paolo, Rocconi, Alessandra, Galliani, Alessandro, Spaziani, G., Tupputi, Salvatore, Cocchi, Camilla, Pirone, Flavia, D'Ignazio, F., Cacciatore, Stefano, Infectious disease, Team, Cauda, Roberto, Tamburrini, Enrica, Borghetti, Alberto, Di Gianbenedetto, S., Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, E., Moschese, D., Ciccullo, A., Dusina, A., Internal Medicine, Team, Stella, L., Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Geltrude, Zocco, Maria Assunta, Microbiology, Team, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, M., Neurology, Team, Bizzarro, Alessandra, Lauria, Alessandra, Ophthalmology, Team, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Cozzupoli, G. M., Culiersi, Carola, Otolaryngology, Team, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, F., Di Cintio, G., Longobardi, Ylenia, Tricarico, Laura, Santantonio, M., Pediatric, Team, Buonsenso, Danilo, Valentini, Piero, Pata, D., Sinatti, Dario, De Rose, Cristina, Pneumology, Team, Richeldi, Luca, Lombardi, F., Calabrese, Anna Chiara, Leone, Paolo Maria, Calvello, M. R., Intini, Enrica, Montemurro, G., Psychiatric, Team, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Giuseppin, G., Molinaro, M., Odica, M., Radiology, Team, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Rheumatology, Team, Paglionico, A., Petricca, Luca, Gigante, Lavinia, Natalello, G., Fedele, Anna Laura, Lizzio, Marco Maria, Tolusso, Barbara, Di Mario, Clara, Alivernini, Stefano, Vascular, Team, Santoliquido, Angelo, Santoro, L., Di Giorgio, A., Nesci, A., Popolla, Valentina, Galluzzo V., Zazzara M. B., Ciciarello F., Savera G., Calvani R. (ORCID:0000-0001-5472-2365), Marzetti E. (ORCID:0000-0001-9567-6983), Landi F. (ORCID:0000-0002-3472-1389), Tosato M., Gremese E. (ORCID:0000-0002-2248-1058), Bernabei R. (ORCID:0000-0002-9197-004X), Fantoni M. (ORCID:0000-0001-6913-8460), Gasbarrini A. (ORCID:0000-0002-7278-4823), Porcari S., Settanni C. R., Bramato G., Brandi V., Fabrizi S., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Martone A. M., Pagano F. C., Rocchi S., Salerno A., Catalano L., Damiano F. P., Rocconi A., Galliani A., Tupputi S., Cocchi C., Pirone F., Cacciatore S., Cauda R. (ORCID:0000-0002-1498-4229), Tamburrini E. (ORCID:0000-0003-4930-426X), Borghetti A., Murri R. (ORCID:0000-0003-4263-7854), Cingolani A. (ORCID:0000-0002-3793-2755), Ventura G. (ORCID:0000-0002-0304-7264), Addolorato G. (ORCID:0000-0002-1522-9946), Franceschi F. (ORCID:0000-0001-6266-445X), Mingrone G. (ORCID:0000-0003-2021-528X), Zocco M. A. (ORCID:0000-0002-0814-9542), Sanguinetti M. (ORCID:0000-0002-9780-7059), Cattani P. (ORCID:0000-0003-4678-4763), Marchetti S., Posteraro B. (ORCID:0000-0002-1663-7546), Bizzarro A., Lauria A., Rizzo S. (ORCID:0000-0001-6302-063X), Savastano M. C. (ORCID:0000-0003-1397-4333), Gambini G., Culiersi C., Passali G. C. (ORCID:0000-0002-8176-0962), Paludetti G. (ORCID:0000-0003-2480-1243), Galli J. (ORCID:0000-0001-6353-6249), Longobardi Y., Tricarico L., Buonsenso D., Valentini P. (ORCID:0000-0001-6095-9510), Sinatti D., De Rose C., Richeldi L. (ORCID:0000-0001-8594-1448), Calabrese A., Leone P. M., Intini E., Sani G. (ORCID:0000-0002-9767-8752), Janiri D., Simonetti A., Natale L. (ORCID:0000-0002-7949-5119), Larici A. R. (ORCID:0000-0002-1882-6244), Marano R. (ORCID:0000-0003-2710-2093), Petricca L., Gigante L., Fedele A. L., Lizzio M. M., Tolusso B. (ORCID:0000-0002-9108-6609), Di Mario C., Alivernini S. (ORCID:0000-0002-7383-4212), Santoliquido A. (ORCID:0000-0003-1539-4017), Popolla V., Galluzzo, Vincenzo, Zazzara, Maria Beatrice, Ciciarello, Francesca, Savera, Giulia, Pais, C., Calvani, Riccardo, Picca, A., Marzetti, Emanuele, Landi, Francesco, Tosato, Matteo, Steering, Committee, Gremese, Elisa, Coordination, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Field, Investigator, Gastroenterology, Team, Porcari, Serena, Settanni, Carlo Romano, Geriatric, Team, Benvenuto, F., Bramato, Giulia, Brandi, Vincenzo, Carfi, A., Fabrizi, Sofia, Lo Monaco, Maria Rita, Martone, Anna Maria, Napolitano, C., Pagano, Francesco Cosimo, Rocchi, Sara, Rota, E., Salerno, Andrea Maria, Tritto, M., Catalano, Lucio, Damiano, Francesco Paolo, Rocconi, Alessandra, Galliani, Alessandro, Spaziani, G., Tupputi, Salvatore, Cocchi, Camilla, Pirone, Flavia, D'Ignazio, F., Cacciatore, Stefano, Infectious disease, Team, Cauda, Roberto, Tamburrini, Enrica, Borghetti, Alberto, Di Gianbenedetto, S., Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, E., Moschese, D., Ciccullo, A., Dusina, A., Internal Medicine, Team, Stella, L., Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Geltrude, Zocco, Maria Assunta, Microbiology, Team, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, M., Neurology, Team, Bizzarro, Alessandra, Lauria, Alessandra, Ophthalmology, Team, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Cozzupoli, G. M., Culiersi, Carola, Otolaryngology, Team, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, F., Di Cintio, G., Longobardi, Ylenia, Tricarico, Laura, Santantonio, M., Pediatric, Team, Buonsenso, Danilo, Valentini, Piero, Pata, D., Sinatti, Dario, De Rose, Cristina, Pneumology, Team, Richeldi, Luca, Lombardi, F., Calabrese, Anna Chiara, Leone, Paolo Maria, Calvello, M. R., Intini, Enrica, Montemurro, G., Psychiatric, Team, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Giuseppin, G., Molinaro, M., Odica, M., Radiology, Team, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Rheumatology, Team, Paglionico, A., Petricca, Luca, Gigante, Lavinia, Natalello, G., Fedele, Anna Laura, Lizzio, Marco Maria, Tolusso, Barbara, Di Mario, Clara, Alivernini, Stefano, Vascular, Team, Santoliquido, Angelo, Santoro, L., Di Giorgio, A., Nesci, A., Popolla, Valentina, Galluzzo V., Zazzara M. B., Ciciarello F., Savera G., Calvani R. (ORCID:0000-0001-5472-2365), Marzetti E. (ORCID:0000-0001-9567-6983), Landi F. (ORCID:0000-0002-3472-1389), Tosato M., Gremese E. (ORCID:0000-0002-2248-1058), Bernabei R. (ORCID:0000-0002-9197-004X), Fantoni M. (ORCID:0000-0001-6913-8460), Gasbarrini A. (ORCID:0000-0002-7278-4823), Porcari S., Settanni C. R., Bramato G., Brandi V., Fabrizi S., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Martone A. M., Pagano F. C., Rocchi S., Salerno A., Catalano L., Damiano F. P., Rocconi A., Galliani A., Tupputi S., Cocchi C., Pirone F., Cacciatore S., Cauda R. (ORCID:0000-0002-1498-4229), Tamburrini E. (ORCID:0000-0003-4930-426X), Borghetti A., Murri R. (ORCID:0000-0003-4263-7854), Cingolani A. (ORCID:0000-0002-3793-2755), Ventura G. (ORCID:0000-0002-0304-7264), Addolorato G. (ORCID:0000-0002-1522-9946), Franceschi F. (ORCID:0000-0001-6266-445X), Mingrone G. (ORCID:0000-0003-2021-528X), Zocco M. A. (ORCID:0000-0002-0814-9542), Sanguinetti M. (ORCID:0000-0002-9780-7059), Cattani P. (ORCID:0000-0003-4678-4763), Marchetti S., Posteraro B. (ORCID:0000-0002-1663-7546), Bizzarro A., Lauria A., Rizzo S. (ORCID:0000-0001-6302-063X), Savastano M. C. (ORCID:0000-0003-1397-4333), Gambini G., Culiersi C., Passali G. C. (ORCID:0000-0002-8176-0962), Paludetti G. (ORCID:0000-0003-2480-1243), Galli J. (ORCID:0000-0001-6353-6249), Longobardi Y., Tricarico L., Buonsenso D., Valentini P. (ORCID:0000-0001-6095-9510), Sinatti D., De Rose C., Richeldi L. (ORCID:0000-0001-8594-1448), Calabrese A., Leone P. M., Intini E., Sani G. (ORCID:0000-0002-9767-8752), Janiri D., Simonetti A., Natale L. (ORCID:0000-0002-7949-5119), Larici A. R. (ORCID:0000-0002-1882-6244), Marano R. (ORCID:0000-0003-2710-2093), Petricca L., Gigante L., Fedele A. L., Lizzio M. M., Tolusso B. (ORCID:0000-0002-9108-6609), Di Mario C., Alivernini S. (ORCID:0000-0002-7383-4212), Santoliquido A. (ORCID:0000-0003-1539-4017), and Popolla V.

Abstract

Background: Fatigue with reduced tolerance to exercise is a common persistent long-lasting feature amongst COVID-19 survivors. The assessment of muscle function in this category of patients is often neglected.Aim.: To evaluate the potential impact of a daily supplementation based on amino acids, minerals, vi-tamins, and plant extracts (Apportal (R)) on muscle function, body composition, laboratory parameters and self-rated health in a small group of COVID-19 survivors affected by fatigue.Methods: Thirty participants were enrolled among patients affected by physical fatigue during or after acute COVID-19 and admitted to the post-COVID-19 outpatient service at Fondazione Policlinico Gemelli in Rome between 1st March 2021 and 30th April 2021. All participants were evaluated at first visit (t0) and at control visit (t1), after taking a daily sachet of Apportal (R) for 28 days. Muscle function was analyzed using hand grip strength test, exhaustion strength time and the number of repetitions at one -minute chair stand test. Body composition was assessed with bioelectrical impedance analysis (BIA). Laboratory parameters, including standard blood biochemistry and ferritin levels, were evaluated at the first visit and during the control visit. A quick evaluation of self-rated health, before COVID-19, at t0 and t1, was obtained through a visual analogue scale (VAS). Results: Participants aged 60 years and older were 13 (43%). Females represented the 70% of the study sample. Participants hospitalized for COVID-19 with low -flow oxygen supplementation represented the 43.3% of the study sample while 3.3% received noninvasive ventilation (NIV) or invasive ventilation. Hand grip strength improved from 26.3 Kg to 28.9 Kg (p < 0.05) at t1 as compared to t0. The mean time of strength exhaustion increased from 31.7 s (sec) at t0 to 47.5 s at t1 (p < 0.05). Participants performed a higher number of repetitions (28.3 vs. 22.0; p < 0.05) during the one-minute chair stand test at

Published
2022

93. Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project)

Author

Bernabei, Roberto, Landi, Francesco, Calvani, Riccardo, Cesari, M., Del Signore, S., Anker, S. D., Bejuit, R., Bordes, P., Cherubini, A., Cruz-Jentoft, A. J., Di Bari, M., Friede, T., Ayestaran, C. G., Goyeau, H., Jonsson, P. V., Kashiwa, M., Lattanzio, F., Maggio, M., Mariotti, L., Miller, R. R., Rodriguez-Manas, L., Roller-Wirnsberger, R., Ryznarova, I., Scholpp, J., Schols, A. M. W. J., Sieber, C. C., Sinclair, A. J., Skalska, A., Strandberg, T., Tchalla, A., Topinkova, E., Tosato, Matteo, Vellas, B., Von Haehling, S., Pahor, M., Roubenoff, R., Marzetti, Emanuele, Bernabei R. (ORCID:0000-0002-9197-004X), Landi F. (ORCID:0000-0002-3472-1389), Calvani R. (ORCID:0000-0001-5472-2365), Tosato M., Marzetti E. (ORCID:0000-0001-9567-6983), Bernabei, Roberto, Landi, Francesco, Calvani, Riccardo, Cesari, M., Del Signore, S., Anker, S. D., Bejuit, R., Bordes, P., Cherubini, A., Cruz-Jentoft, A. J., Di Bari, M., Friede, T., Ayestaran, C. G., Goyeau, H., Jonsson, P. V., Kashiwa, M., Lattanzio, F., Maggio, M., Mariotti, L., Miller, R. R., Rodriguez-Manas, L., Roller-Wirnsberger, R., Ryznarova, I., Scholpp, J., Schols, A. M. W. J., Sieber, C. C., Sinclair, A. J., Skalska, A., Strandberg, T., Tchalla, A., Topinkova, E., Tosato, Matteo, Vellas, B., Von Haehling, S., Pahor, M., Roubenoff, R., Marzetti, Emanuele, Bernabei R. (ORCID:0000-0002-9197-004X), Landi F. (ORCID:0000-0002-3472-1389), Calvani R. (ORCID:0000-0001-5472-2365), Tosato M., and Marzetti E. (ORCID:0000-0001-9567-6983)

Abstract

Objective To determine whether a multicomponent intervention based on physical activity with technological support and nutritional counselling prevents mobility disability in older adults with physical frailty and sarcopenia. Design Evaluator blinded, randomised controlled trial. Setting 16 clinical sites across 11 European countries, January 2016 to 31 October 2019. Participants 1519 community dwelling men and women aged 70 years or older with physical frailty and sarcopenia, operationalised as the co-occurrence of low functional status, defined as a short physical performance battery (SPPB) score of 3 to 9, low appendicular lean mass, and ability to independently walk 400 m. 760 participants were randomised to a multicomponent intervention and 759 received education on healthy ageing (controls). Interventions The multicomponent intervention comprised moderate intensity physical activity twice weekly at a centre and up to four times weekly at home. Actimetry data were used to tailor the intervention. Participants also received personalised nutritional counselling. Control participants received education on healthy ageing once a month. Interventions and follow-up lasted for up to 36 months. Main outcome measures The primary outcome was mobility disability (inability to independently walk 400 m in <15 minutes). Persistent mobility disability (inability to walk 400 m on two consecutive occasions) and changes from baseline to 24 and 36 months in physical performance, muscle strength, and appendicular lean mass were analysed as pre-planned secondary outcomes. Primary comparisons were conducted in participants with baseline SPPB scores of 3-7 (n=1205). Those with SPPB scores of 8 or 9 (n=314) were analysed separately for exploratory purposes. Results Mean age of the 1519 participants (1088 women) was 78.9 (standard deviation 5.8) years. The average follow-up was 26.4 (SD 9.5) months. Among participants with SPPB scores of 3-7, mobility disability occurred in 283/605 (

Published
2022

94. Gait characteristics in community-dwelling older persons with low skeletal muscle mass and low physical performance

Author

Longobucco, Y., Krumpoch, S., Lauretani, F., Angileri, V., Sieber, C., Marzetti, Emanuele, Calvani, Riccardo, Cherubini, A., Landi, Francesco, Bernabei, Roberto, Freiberger, E., Maggio, M., Marzetti E. (ORCID:0000-0001-9567-6983), Calvani R. (ORCID:0000-0001-5472-2365), Landi F. (ORCID:0000-0002-3472-1389), Bernabei R. (ORCID:0000-0002-9197-004X), Longobucco, Y., Krumpoch, S., Lauretani, F., Angileri, V., Sieber, C., Marzetti, Emanuele, Calvani, Riccardo, Cherubini, A., Landi, Francesco, Bernabei, Roberto, Freiberger, E., Maggio, M., Marzetti E. (ORCID:0000-0001-9567-6983), Calvani R. (ORCID:0000-0001-5472-2365), Landi F. (ORCID:0000-0002-3472-1389), and Bernabei R. (ORCID:0000-0002-9197-004X)

Abstract

Background: Demographic changes in the western world entail new clinical approaches and challenges in older persons. Low skeletal muscle mass and low physical performance in older persons are both predisposing conditions for disability and obtaining knowledge in this cohort is essential. Aim: The primary aim of the study was to analyze a broader spectrum of gait characteristics within this specific population and differentiate them across different test conditions. Methods: Two centers participating at the SPRINTT project with hi-tech gait analysis available conducted a cross-sectional descriptive study on N = 115 community-dwelling older persons with low muscle mass and physical performance. Reference values of 13 gait parameters were collected across different conditions: usual gait speed, fast gait speed, and usual gait speed while simultaneously naming animals. Results and discussion: This study shows the first spatio-temporal reference values in a community-dwelling older population composed of individuals with low skeletal muscle mass and low physical performance. In comparison to the normative spatio-temporal gait parameters in older persons reported in the literature, this population showed some differences. The mean gait speed was lower than 1 m/s, considered as a cutoff for vulnerable community-dwelling individuals, which corresponds to a greater risk of falls, hospitalization, and mortality. The stride length variability was higher, exposing to a greater risk of falling, and was also associated with a higher risk of developing cognitive decline. Conclusion: This study represents the first step in the development of quantitative reference values in community-dwelling older persons with low physical performance and low skeletal muscle mass.

Published
2022

96. Assessing and Measuring Chronic Multimorbidity in the Older Population: A Proposal for Its Operationalization

Author

Calderón-Larrañaga, Amaia, Vetrano, Davide L, Onder, Graziano, Gimeno-Feliu, Luis A, Coscollar-Santaliestra, Carlos, Carfí, Angelo, Pisciotta, Maria S, Angleman, Sara, Melis, René J F, Santoni, Giola, Mangialasche, Francesca, Rizzuto, Debora, Welmer, Anna-Karin, Bernabei, Roberto, Prados-Torres, Alexandra, Marengoni, Alessandra, and Fratiglioni, Laura

Published
2017
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