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51. Publisher Correction: Mendelian randomisation study of the relationship between vitamin D and risk of glioma

Author

Takahashi, Hannah, Cornish, Alex J., Sud, Amit, Law, Philip J., Kinnersley, Ben, Ostrom, Quinn T., Labreche, Karim, Eckel-Passow, Jeanette E., Armstrong, Georgina N., Claus, Elizabeth B., Il’yasova, Dora, Schildkraut, Joellen, Barnholtz-Sloan, Jill S., Olson, Sara H., Bernstein, Jonine L., Lai, Rose K., Schoemaker, Minouk J., Simon, Matthias, Hoffmann, Per, Nöthen, Markus M., Jöckel, Karl-Heinz, Chanock, Stephen, Rajaraman, Preetha, Johansen, Christoffer, Jenkins, Robert B., Melin, Beatrice S., Wrensch, Margaret R., Sanson, Marc, Bondy, Melissa L., Turnbull, Clare, and Houlston, Richard S.

Published
2019
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52. Association of Common Genetic Variants With Contralateral Breast Cancer Risk in the WECARE Study

Author

Robson, Mark E., Reiner, Anne S., Brooks, Jennifer D., Concannon, Patrick J., John, Esther M., Mellemkjaer, Lene, Bernstein, Leslie, Malone, Kathleen E., Knight, Julia A., Lynch, Charles F., Woods, Meghan, Liang, Xiaolin, Haile, Robert W., Duggan, David J., Shore, Roy E., Smith, Susan A., Thomas, Duncan C., Stram, Daniel O., and Bernstein, Jonine L.

Published
2017
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54. The predictive ability of the 313 variant–based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant

Author

Lakeman, Inge M. M., Van Den Broek, Alexandra J., Vos, Juliën A. M., Barnes, Daniel R., Adlard, Julian, Andrulis, Irene L., Arason, Adalgeir, Arnold, Norbert, Arun, Banu K., Balmaña, Judith, Barrowdale, Daniel, Giraud, Sophie, Golmard, Lisa, Hake, Christopher R., Houdayer, Claude, Risch, Harvey A., Lasset, Christine, Laurent, Maïté, Spurdle, Amanda B., Hooning, Maartje J., Hopper, John L., Kets, Carolien M., Leroux, Dominique, Longy, Michel, Mari, Véronique, Mazoyer, Sylvie, Mebirouk, Noura, Mortemousque, Isabelle, Blok, Marinus J., Prieur, Fabienne, Hamann, Ute, Pujol, Pascal, Konstantopoulou, Irene, Heemskerk Gerritsen, Bernadette A. M., Isaacs, Claudine, Saule, Claire, Piedmonte, Marion, Schuster, Helene, Sevenet, Nicolas, Sobol, Hagay, Sokolowska, Johanna, Gómez Garcia, Encarna B., Venat Bouvet, Laurence, Claes, Kathleen B. M., Ahmed, Munaza, Teixeira, Manuel R., Barwell, Julian, Brady, Angela, Izatt, Louise, Hogervorst, Frans B. L., Brennan, Paul, Harrington, Patricia A., Henderson, Alex, Hodgson, Shirley, Kwong, Ava, Borg, Ake, Kennedy, M. John, Porteous, Mary E., Rogers, Mark T., Side, Lucy E., Snape, Katie, Walker, Lisa, Collée, J. Margriet, Jakubowska, Anna, Couch, Fergus J., Hahnen, Eric, Daly, Mary B., Dennis, Joe, Teo, Soo Hwang, Jensen, Uffe Birk, Rantala, Johanna, Dhawan, Mallika, Benitez, Javier, Domchek, Susan M., Eeles, Ros, Engel, Christoph, Legrand, Clémentine, Evans, D. Gareth, James, Paul A., Feliubadaló i Elorza, Maria Lídia, Teulé-Vega, Àlex, Foretova, Lenka, Castera, Laurent, Friedman, Eitan, Frost, Debra, Rennert, Gad, Ganz, Patricia A., Leslie, Goska, Garber, Judy, Hulick, Peter J., Imyanitov, Evgeny N., Glendon, Gord, Thomassen, Mads, Janavicius, Ramunas, Mulligan, Anna Marie, Hollestelle, Antoinette, Jager, Agnes, Koppert, Linetta B., Cook, Jackie, Koudijs, Marco, Kriege, Mieke, Meijers Heijboer, Hanne E. J., Schmutzler, Rita K., Mensenkamp, Arjen R., Dunning, Alison M., Mooij, Thea M., Oosterwijk, Jan C., Caux Moncoutier, Virginie, Singer, Christian F., Berthet, Pascaline, Caldés, Trinidad, Van den Ouweland, Ans M. W., Van der Baan, Frederieke H., Van der Hout, Annemieke H., Van der Kolk, Lizet E., Van der Luijt, Rob B., Thull, Darcy L., Van Deurzen, Carolien H. M., Sharma, Priyanka, Van Doorn, Helena C., Bignon, Yves Jean, Colas, Chrystelle, Van Engelen, Klaartje, Brewer, Carole, Van Hest, Liselotte P., Van Os, Theo A. M., Caligo, Maria A., Verhoef, Senno, Tischkowitz, Marc, Vogel, Maartje J., Wijnen, Juul T., Lalloo, Fiona, Beesley, Jonathan, Fox, Stephen, Collonge Rame, Marie Agnès, Simard, Jacques, Holland, Helene, Jiao, Yue, John, Esther M., Joseph, Vijai, Gerdes, Anne Marie, Karlan, Beth Y., Lesueur, Fabienne, Loud, Jennifer T., Lubiński, Jan, Manoukian, Siranoush, Mcguffog, Lesley, Miller, Austin, Coupier, Isabelle, Gomes, Denise Molina, Barouk Simonet, Emmanuelle, Montagna, Marco, Miller, Clare, Elan, Camille, Davidson, Rosemarie, Mouret Fourme, Emmanuelle, Gayther, Simon A., Nathanson, Katherine L., Neuhausen, Susan L., Nevanlinna, Heli, Yie, Joanne Ngeow Yuen, Pauw, Antoine de, Olah, Edith, Morrison, Patrick J., Olopade, Olufunmilayo I., Van Asperen, Christi J., Park, Sue K., Parsons, Michael T., Donaldson, Alan, Belotti, Muriel, Peterlongo, Paolo, Stadler, Zsofia, Stoppa Lyonnet, Dominique, Sutter, Christian, Ong, Kai Ren, Delnatte, Capucine, Tan, Yen Yen, Toland, Amanda E., Tung, Nadine, Van Rensburg, Elizabeth J., Vega, Ana, Wappenschmidt, Barbara, Devilee, Peter, Eason, Jacqueline, Chung, Wendy K., Bernstein, Jonine L., Offit, Kenneth, Aalfs, Cora M., Hanson, Helen, Godwin, Andrew K., Easton, Douglas F., Bonadona, Valérie, Rookus, Matti A., Chenevix-Trench, Georgia, Antoniou, Antonis C., O’shaughnessy Kirwan, Aoife, Robson, Mark, Eccles, Diana M., Schmidt, Marjanka K., Adank, Muriel A., Gemo Study Collaborators, Phillips, Kelly Anne, Embrace Collaborators, Ocgn Investigators, Goldgar, David E., Hebon Investigators, Perkins, Jo, Kconfab Investigators, Bressac de Paillerets, Brigitte, Buecher, Bruno, Caputo, Sandrine, Ausems, Margreet G. E. M., Gregory, Helen, Caron, Olivier, Faivre, Laurence, Fert Ferrer, Sandra, Gauthier Villars, Marion, Radice, Paolo, Gesta, Paul, Clinical Genetics, Medical Oncology, Surgery, Pathology, Gynecological Oncology, Schmidt, Marjanka K. [0000-0002-2228-429X], Apollo - University of Cambridge Repository, Targeted Gynaecologic Oncology (TARGON), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Schmidt, Marjanka K [0000-0002-2228-429X], HUS Gynecology and Obstetrics, Department of Obstetrics and Gynecology, Institut Català de la Salut, [Lakeman IMM] Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. [van den Broek AJ, Vos JAM] Division of Molecular Pathology, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. [Barnes DR] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [Adlard J] Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK. [Andrulis IL] Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. [Balmaña J] Hereditary cancer Genetics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Pediatric surgery, Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, CCA - Cancer biology and immunology, Epidemiology and Data Science, Human Genetics, ARD - Amsterdam Reproduction and Development, APH - Personalized Medicine, APH - Quality of Care, Chapel Allerton Hospital, University of Leeds, Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto-Cancer Care Ontario, Reykjavík University, Division of Oncology, Department of Gynaecology and Obstetrics, University Hospital Schleswig–Holstein, The University of Texas M.D. Anderson Cancer Center [Houston], Unitat d'Alt Risc i Prevenció del Càncer, Vall d'Hebron University Hospital [Barcelona], University of Cambridge [UK] (CAM), Group of Human Genetics, Human Cancer Genetics Programme, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Department of Oncology, Clinical Sciences, Lund University [Lund]-Skåne University Hospital, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Section of Genetic Oncology, University of Pisa - Università di Pisa, Columbia University [New York], Ghent University Hospital, Department of Clinical Genetics, Erasmus University Medical Center [Rotterdam] (Erasmus MC)-Family Cancer Clinic, Department of Laboratory Medicine and Pathology, Mayo Clinic, Division of Population Science, Fox Chase Cancer Center, Institut Curie [Paris], Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL), CHU Grenoble, CHI Poissy-Saint-Germain, Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: DA KG Lab Centraal Lab (9), MUMC+: DA KG Polikliniek (9), and Klinische Genetica

Subjects
0301 basic medicine, Percentile, Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease [DISEASES], Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES], SUSCEPTIBILITY ALLELES, Diàtesi, FAMILIES, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], MESH: BRCA2 Protein, Breast cancer, 0302 clinical medicine, MESH: Risk Factors, Risk Factors, Other subheadings::/diagnosis [Other subheadings], Medicine and Health Sciences, Medicine, Mama - Càncer - Diagnòstic, Family history, skin and connective tissue diseases, Genetics (clinical), MESH: Heterozygote, neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES], Factors de risc en les malalties, BRCA1 Protein, Hazard ratio, MESH: Genetic Predisposition to Disease, 1184 Genetics, developmental biology, physiology, article, OVARIAN, BRCA2 Protein/genetics, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], 3. Good health, 030220 oncology & carcinogenesis, Female, Malalties congènites, Adult, Heterozygote, medicine.medical_specialty, MESH: Mutation, Risk factors in diseases, Otros calificadores::/diagnóstico [Otros calificadores], Breast Neoplasms, Context (language use), MUTATION CARRIERS, Càncer de mama, afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::susceptibilidad a enfermedades::predisposición genética a la enfermedad [ENFERMEDADES], 03 medical and health sciences, SDG 3 - Good Health and Well-being, Internal medicine, Humans, Genetic Predisposition to Disease, MESH: BRCA1 Protein, Retrospective Studies, BRCA2 Protein, MESH: Humans, business.industry, Proportional hazards model, CONSORTIUM, Breast Neoplasms/diagnosis, MESH: Adult, MESH: Retrospective Studies, Retrospective cohort study, medicine.disease, Confidence interval, 030104 developmental biology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Mutation, BRCA1 Protein/genetics, 3111 Biomedicine, business, MESH: Female, MESH: Breast Neoplasms
Abstract

Predicció de risc de càncer de mama; Dones europees; Variant patògena heterozigota Predicción del riesgo de cáncer de mama; Mujeres europeas; Variante patógena heterocigota Breast cancer risk prediction; European women; Heterozygous pathogenic variant Purpose To evaluate the association between a previously published 313 variant–based breast cancer (BC) polygenic risk score (PRS313) and contralateral breast cancer (CBC) risk, in BRCA1 and BRCA2 pathogenic variant heterozygotes. Methods We included women of European ancestry with a prevalent first primary invasive BC (BRCA1 = 6,591 with 1,402 prevalent CBC cases; BRCA2 = 4,208 with 647 prevalent CBC cases) from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA), a large international retrospective series. Cox regression analysis was performed to assess the association between overall and ER-specific PRS313 and CBC risk. Results For BRCA1 heterozygotes the estrogen receptor (ER)-negative PRS313 showed the largest association with CBC risk, hazard ratio (HR) per SD = 1.12, 95% confidence interval (CI) (1.06–1.18), C-index = 0.53; for BRCA2 heterozygotes, this was the ER-positive PRS313, HR = 1.15, 95% CI (1.07–1.25), C-index = 0.57. Adjusting for family history, age at diagnosis, treatment, or pathological characteristics for the first BC did not change association effect sizes. For women developing first BC

Published
2021

57. Contralateral breast cancers: Independent cancers or metastases?

Author

Begg, Colin B., Ostrovnaya, Irina, Geyer, Felipe C., Papanastasiou, Anastasios D., Ng, Charlotte K.Y., Sakr, Rita A., Bernstein, Jonine L., Burke, Kathleen A., King, Tari A., Piscuoglio, Salvatore, Mauguen, Audrey, Orlow, Irene, Weigelt, Britta, Seshan, Venkatraman E., Morrow, Monica, and Reis‐Filho, Jorge S.

Published
2018
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59. Impact of atopy on risk of glioma: a Mendelian randomisation study

Author

Disney-Hogg, Linden, Cornish, Alex J., Sud, Amit, Law, Philip J., Kinnersley, Ben, Jacobs, Daniel I., Ostrom, Quinn T., Labreche, Karim, Eckel-Passow, Jeanette E., Armstrong, Georgina N., Claus, Elizabeth B., Il’yasova, Dora, Schildkraut, Joellen, Barnholtz-Sloan, Jill S., Olson, Sara H., Bernstein, Jonine L., Lai, Rose K., Schoemaker, Minouk J., Simon, Matthias, Hoffmann, Per, Nöthen, Markus M., Jöckel, Karl-Heinz, Chanock, Stephen, Rajaraman, Preetha, Johansen, Christoffer, Jenkins, Robert B., Melin, Beatrice S., Wrensch, Margaret R., Sanson, Marc, Bondy, Melissa L., and Houlston, Richard S.

Published
2018
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62. Association of contralateral breast cancer risk with mammographic density defined at higher‐than‐conventional intensity thresholds

Author

Watt, Gordon P., primary, Knight, Julia A., additional, Nguyen, Tuong L., additional, Reiner, Anne S., additional, Malone, Kathleen E., additional, John, Esther M., additional, Lynch, Charles F., additional, Brooks, Jennifer D., additional, Woods, Meghan, additional, Liang, Xiaolin, additional, Bernstein, Leslie, additional, Pike, Malcolm C., additional, Hopper, John L., additional, and Bernstein, Jonine L., additional

Published
2022
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63. Common variants in genes coding for chemotherapy metabolizing enzymes, transporters, and targets: a case–control study of contralateral breast cancer risk in the WECARE Study

Author

The WECARE Study Collaborative Group, Brooks, Jennifer D., Teraoka, Sharon N., Bernstein, Leslie, Mellemkjær, Lene, Malone, Kathleen E., Lynch, Charles F., Haile, Robert W., Concannon, Patrick, Reiner, Anne S., Duggan, David J., Schiermeyer, Katherine, Bernstein, Jonine L., and Figueiredo, Jane C.

Published
2013

66. Radiation disasters – long term consequences: reflections and summary of a recent symposium.

Author

Burtt, Julie J., Akiba, Suminori, Bazyka, Dimitry, Coleman, C. Norman, Hatch, Maureen, and Bernstein, Jonine L.

Subjects
THYROID cancer, THYROID diseases, RADIATION, NUCLEAR power plant accidents, SENDAI Earthquake, Japan, 2011, MEDICAL sciences
Abstract

A cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: thyroid cancer in Ukraine detected during first screening. A significant excess of multiple myeloma incidence [standardized incidence rate (SIR) 1.61; 95% confidence interval (CI) 1.01-2.21], thyroid cancer (SIR 4.18, 95% CI 3.76-4.59), female breast cancer (SIR1.57 CI 1.40-1.73), and all cancers combined (SIR 1.07; 95% CI 1.05-1.09) was registered (Bazyka et al. [8]). Thoughts and substantial progress of the radiation research field regarding the Fukushima nuc... The knowledge from the field of radiation epidemiology has a critical impact on cancer management, industry regulations and energy policy. Keywords: Nuclear disasters; long-term consequences of radiation exposure; emergency response EN Nuclear disasters long-term consequences of radiation exposure emergency response 561 568 8 02/28/23 20230301 NES 230301 Introduction One of the most compelling challenges in radiation epidemiology is the scientific evaluation of the long-term health consequences following nuclear radiation disasters. [Extracted from the article]

Published
2023
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70. Germline Mutations in Shelterin Complex Genes Are Associated With Familial Glioma

Author

Bainbridge, Matthew N., Armstrong, Georgina N., Gramatges, M. Monica, Bertuch, Alison A., Jhangiani, Shalini N., Doddapaneni, Harsha, Lewis, Lora, Tombrello, Joseph, Tsavachidis, Spyros, Liu, Yanhong, Jalali, Ali, Plon, Sharon E., Lau, Ching C., Parsons, Donald W., Claus, Elizabeth B., Barnholtz-Sloan, Jill, Il’yasova, Dora, Schildkraut, Joellen, Ali-Osman, Francis, Sadetzki, Siegal, Johansen, Christoffer, Houlston, Richard S., Jenkins, Robert B., Lachance, Daniel, Olson, Sara H., Bernstein, Jonine L., Merrell, Ryan T., Wrensch, Margaret R., Walsh, Kyle M., Davis, Faith G., Lai, Rose, Shete, Sanjay, Aldape, Kenneth, Amos, Christopher I., Thompson, Patricia A., Muzny, Donna M., Gibbs, Richard A., Melin, Beatrice S., and Bondy, Melissa L.

Published
2015
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71. The Emergence of Networks in Human Genome Epidemiology: "Challenges and Opportunities"

Author

Seminara, Daniela, Khoury, Muin J., O'Brien, Thomas R., Manolio, Teri, Gwinn, Marta L., Little, Julian, Higgins, Julian P. T., Bernstein, Jonine L., Boffetta, Paolo, Bondy, Melissa, Bray, Molly S., Brenchley, Paul E., Buffler, Patricia A., Casas, Juan Pablo, Chokkalingam, Anand P., Danesh, John, Smith, George Davey, Dolan, Siobhan, Duncan, Ross, Gruis, Nelleke A., Hashibe, Mia, Hunter, David, Jarvelin, Marjo-Riitta, Malmer, Beatrice, Maraganore, Demetrius M., Newton-Bishop, Julia A., Riboli, Elio, Salanti, Georgia, Taioli, Emanuela, Timpson, Nic, Uitterlinden, André G., Vineis, Paolo, Wareham, Nick, Winn, Deborah M., Zimmern, Ron, and Ioannidis, John P. A.

Published
2007
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72. Supplement to: Breast-cancer risk in families with mutations in PALB2.

Author

Antoniou, Antonis C., Casadei, Silvia, Heikkinen, Tuomas, Barrowdale, Daniel, Pylkäs, Katri, Roberts, Jonathan, Lee, Andrew, Subramanian, Deepak, De Leeneer, Kim, Fostira, Florentia, Tomiak, Eva, Neuhausen, Susan L., Teo, Zhi L., Khan, Sofia, Aittomäki, Kristiina, Moilanen, Jukka S., Turnbull, Clare, Seal, Sheila, Mannermaa, Arto, Kallioniemi, Anne, Lindeman, Geoffrey J., Buys, Saundra S., Andrulis, Irene, Radice, Paolo, Tondini, Carlo, Manoukian, Siranoush, Toland, Amanda E., Miron, Penelope, kConFab, Weitzel, Jeffery N., Domchek, Susan, Poppe, Bruce, Claes, Katheen B.M., Yannoukakos, Drakoulis, Concannon, Patrick, Bernstein, Jonine L., James, Paul A., Easton, Douglas, Goldgar, David E., Hopper, John L., Rahman, Nazneen, Peterlongo, Paolo, Nevanlinna, Heli, King, Mary-Claire, Couch, Fergus J, Southey, Melissa C., Winqvist, Robert, Foulkes, William D., and Tischkowitz, Marc

Published
2014

73. First international workshop of the ATM and cancer risk group (4-5 December 2019)

Author

Lesueur, Fabienne, Easton, Douglas F, Renault, Anne-Laure, Tavtigian, Sean V, Bernstein, Jonine L, Kote-Jarai, Zsofia, Eeles, Rosalind A, Plaseska-Karanfia, Dijana, Feliubadaló, Lidia, Spanish ATM Working Group, Arun, Banu, Herold, Natalie, Versmold, Beatrix, Schmutzler, Rita Katharina, GC-HBOC, Nguyen-Dumont, Tú, Southey, Melissa C, Dorling, Leila, Dunning, Alison M, Ghiorzo, Paola, Dalmasso, Bruna Samia, Cavaciuti, Eve, Le Gal, Dorothée, Roberts, Nicholas J, Dominguez-Valentin, Mev, Rookus, Matti, Taylor, Alexander MR, Goldstein, Alisa M, Goldgar, David E, CARRIERS And Ambry Groups, Stoppa-Lyonnet, Dominique, Andrieu, Nadine, Andrieu, Nadine [0000-0001-8820-5550], and Apollo - University of Cambridge Repository

Subjects
Heterozygote, Variants classification, Tumor profiles, Breast Neoplasms, Ataxia Telangiectasia Mutated Proteins, Cancer spectrum, Cancer risk, Ataxia Telangiectasia, ATM, Neoplasms, Humans, Female, Genetic Predisposition to Disease, France
Abstract

The first International Workshop of the ATM and Cancer Risk group focusing on the role of Ataxia-Telangiectasia Mutated (ATM) gene in cancer was held on December 4 and 5, 2019 at Institut Curie in Paris, France. It was motivated by the fact that germline ATM pathogenic variants have been found to be associated with different cancer types. However, due to the lack of precise age-, sex-, and site-specific risk estimates, no consensus on management guidelines for variant carriers exists, and the clinical utility of ATM variant testing is uncertain. The meeting brought together epidemiologists, geneticists, biologists and clinicians to review current knowledge and on-going challenges related to ATM and cancer risk. This report summarizes the meeting sessions content that covered the latest results in family-based and population-based studies, the importance of accurate variant classification, the effect of radiation exposures for ATM variant carriers, and the characteristics of ATM-deficient tumors. The report concludes that ATM variant carriers outside of the context of Ataxia-Telangiectasia may benefit from effective cancer risk management and therapeutic strategies and that efforts to set up large-scale studies in the international framework to achieve this goal are necessary.

Published
2021
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74. Coronary Artery Disease in Young Women After Radiation Therapy for Breast Cancer

Author

Carlson, Lauren E., primary, Watt, Gordon P., additional, Tonorezos, Emily S., additional, Chow, Eric J., additional, Yu, Anthony F., additional, Woods, Meghan, additional, Lynch, Charles F., additional, John, Esther M., additional, Mellemkjӕr, Lene, additional, Brooks, Jennifer D., additional, Knight, Julia A., additional, Reiner, Anne S., additional, Liang, Xiaolin, additional, Smith, Susan A., additional, Bernstein, Leslie, additional, Dauer, Lawrence T., additional, Cerviño, Laura I., additional, Howell, Rebecca M., additional, Shore, Roy E., additional, Boice, John D., additional, Bernstein, Jonine L., additional, Capanu, Marinela, additional, Orlow, Irene, additional, Robson, Mark, additional, Olsen, Jørgen H., additional, Malone, Kathleen E., additional, Stovall, Marilyn, additional, Blackmore, Kristina, additional, Harris, Irene, additional, Langballe, Rikke, additional, O’Brien, Cecilia, additional, Weathers, Rita, additional, West, Michele, additional, Hunter, Lisa, additional, Goldstein, Judy, additional, and Ramos, Elaine, additional

Published
2021
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75. Searching for causal relationships of glioma:a phenome-wide Mendelian randomisation study

Author

Saunders, Charlie N., Cornish, Alex J., Kinnersley, Ben, Law, Philip J., Houlston, Richard S., Claus, Elizabeth B., Il’yasova, Dora, Schildkraut, Joellen, Barnholtz-Sloan, Jill S., Olson, Sara H., Bernstein, Jonine L., Lai, Rose K., Chanock, Stephen, Rajaraman, Preetha, Johansen, Christoffer, Jenkins, Robert B., Melin, Beatrice S., Wrensch, Margaret R., Sanson, Marc, and Bondy, Melissa L.

Subjects
Oncology, 0303 health sciences, Cancer Research, medicine.medical_specialty, business.industry, Genome-wide association study, Odds ratio, Phenome, medicine.disease, Phenotype, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, 030220 oncology & carcinogenesis, Glioma, Internal medicine, medicine, Etiology, Mendelian inheritance, symbols, business, 030304 developmental biology, Genetic association
Abstract

Background The aetiology of glioma is poorly understood. Summary data from genome-wide association studies (GWAS) can be used in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to search for glioma risk factors. Methods We performed an MR-PheWAS analysing 316 phenotypes, proxied by 8387 genetic variants, and summary genetic data from a GWAS of 12,488 glioma cases and 18,169 controls. Causal effects were estimated under a random-effects inverse-variance-weighted (IVW-RE) model, with robust adjusted profile score (MR-RAPS), weighted median and mode-based estimates computed to assess the robustness of findings. Odds ratios per one standard deviation increase in each phenotype were calculated for all glioma, glioblastoma (GBM) and non-GBM tumours. Results No significant associations (P −4) were observed between phenotypes and glioma under the IVW-RE model. Suggestive associations (1.58 × 10−4 P SD = 3.91, P = 9.24 × 10−3) and GBM (ORSD = 4.86, P = 3.23 × 10−2), but the association was primarily driven by the TERT variant rs2736100. Serum low-density lipoprotein cholesterol and plasma HbA1C showed suggestive associations with glioma (ORSD = 1.11, P = 1.39 × 10−2 and ORSD = 1.28, P = 1.73 × 10−2, respectively), both associations being reliant on single genetic variants. Conclusions Our study provides further insight into the aetiological basis of glioma for which published data have been mixed.

Published
2021

76. Common variants in genes coding for chemotherapy metabolizing enzymes, transporters, and targets: a case–control study of contralateral breast cancer risk in the WECARE Study

Author

Brooks, Jennifer D., Teraoka, Sharon N., Bernstein, Leslie, Mellemkjær, Lene, Malone, Kathleen E., Lynch, Charles F., Haile, Robert W., Concannon, Patrick, Reiner, Anne S., Duggan, David J., Schiermeyer, Katherine, Bernstein, Jonine L., Figueiredo, Jane C., and The WECARE Study Collaborative Group

Published
2013
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78. Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study

Author

Reiner, Anne S, Sisti, Julia, John, Esther M, Lynch, Charles F, Brooks, Jennifer D, Mellemkjær, Lene, Boice, John D, Knight, Julia A, Concannon, Patrick, Capanu, Marinela, Tischkowitz, Marc, Robson, Mark, Liang, Xiaolin, Woods, Meghan, Conti, David V, Duggan, David, Shore, Roy, Stram, Daniel O, Thomas, Duncan C, Malone, Kathleen E, Bernstein, Leslie, WECARE Study Collaborative Group, Bernstein, Jonine L, Tischkowitz, Marc [0000-0002-7880-0628], and Apollo - University of Cambridge Repository

Subjects
Adult, BRCA2 Protein, Canada, Adolescent, Genotype, BRCA1 Protein, Denmark, Age Factors, Breast Neoplasms, Middle Aged, Polymorphism, Single Nucleotide, United States, Checkpoint Kinase 2, Risk Factors, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Neoplasm Invasiveness, skin and connective tissue diseases, Fanconi Anemia Complementation Group N Protein
Abstract

Purpose The Women's Environmental Cancer and Radiation Epidemiology (WECARE) study demonstrated the importance of breast cancer family history on contralateral breast cancer (CBC) risk, even for noncarriers of deleterious BRCA1/2 mutations. With the completion of WECARE II, updated risk estimates are reported. Additional analyses that exclude women negative for deleterious mutations in ATM, CHEK2*1100delC, and PALB2 were performed. Patients and Methods The WECARE Study is a population-based case-control study that compared 1,521 CBC cases with 2,212 individually matched unilateral breast cancer (UBC) controls. Participants were younger than age 55 years when diagnosed with a first invasive breast cancer between 1985 and 2008. Women were interviewed about breast cancer risk factors, including family history. A subset of women was screened for deleterious mutations in BRCA1/2, ATM, CHEK2*1100delC, and PALB2. Rate ratios (RRs) were estimated using multivariable conditional logistic regression. Cumulative absolute risks (ARs) were estimated by combining RRs from the WECARE Study and population-based SEER*Stat cancer incidence data. Results Women with any first-degree relative with breast cancer had a 10-year AR of 8.1% for CBC (95% CI, 6.7% to 9.8%). Risks also were increased if the relative was diagnosed at an age younger than 40 years (10-year AR, 13.5%; 95% CI, 8.8% to 20.8%) or with CBC (10-year AR, 14.1%; 95% CI, 9.5% to 20.7%). These risks are comparable with those seen in BRCA1/2 deleterious mutation carriers (10-year AR, 18.4%; 95% CI, 16.0% to 21.3%). In the subset of women who tested negative for deleterious mutations in BRCA1/2, ATM, CHEK2*1100delC, and PALB2, estimates were unchanged. Adjustment for known breast cancer single-nucleotide polymorphisms did not affect estimates. Conclusion Breast cancer family history confers a high CBC risk, even after excluding women with deleterious mutations. Clinicians are urged to use detailed family histories to guide treatment and future screening decisions for young women with breast cancer.

Published
2020
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80. Risk of contralateral breast cancer associated with common variants in BRCA1 and BRCA2: potential modifying effect of BRCA1/BRCA2 mutation carrier status

Author

Figueiredo, Jane C., Brooks, Jennifer D., Conti, David V., Poynter, Jenny N., Teraoka, Sharon N., Malone, Kathleen E., Bernstein, Leslie, Lee, Won D., Duggan, David J., Siniard, Ashley, Concannon, Patrick, Capanu, Marinela, Lynch, Charles F., Olsen, Jørgen H., Haile, Robert W., and Bernstein, Jonine L.

Published
2011
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81. Survey of familial glioma and role of germline p16 INK4A /p14 ARF and p53 mutation

Author

Robertson, Lindsay B., Armstrong, Georgina N., Olver, Bianca D., Lloyd, Amy L., Shete, Sanjay, Lau, Ching, Claus, Elizabeth B., Barnholtz-Sloan, Jill, Lai, Rose, Il’yasova, Dora, Schildkraut, Joellen, Bernstein, Jonine L., Olson, Sara H., Jenkins, Robert B., Yang, Ping, Rynerason, Amanda L., Wrensch, Margaret, McCoy, Lucie, Wienkce, John K., McCarthy, Bridget, Davis, Faith, Vick, Nicholas A., Johansen, Christoffer, Bødtcher, Hanne, Sadetzki, Siegal, Bruchim, Revital Bar-Sade, Yechezkel, Galit Hirsh, Andersson, Ulrika, Melin, Beatrice S., Bondy, Melissa L., and Houlston, Richard S.

Published
2010
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82. Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study

Author

Figueiredo, Jane C., Haile, Robert W., Bernstein, Leslie, Malone, Kathleen E., Largent, Joan, Langholz, Bryan, Lynch, Charles F., Bertelsen, Lisbeth, Capanu, Marinela, Concannon, Patrick, Borg, Ake, Børresen-Dale, Anne-Lise, Diep, Anh, Teraoka, Sharon, Torngren, Therese, Xue, Shanyan, and Bernstein, Jonine L.

Published
2010
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83. Breast-Cancer Risk in Families with Mutations in PALB2

Author

Antoniou, Antonis C., Casadei, Silvia, Heikkinen, Tuomas, Barrowdale, Daniel, Pylkäs, Katri, Roberts, Jonathan, Lee, Andrew, Subramanian, Deepak, De Leeneer, Kim, Fostira, Florentia, Tomiak, Eva, Neuhausen, Susan L., Teo, Zhi L., Khan, Sofia, Aittomäki, Kristiina, Moilanen, Jukka S., Turnbull, Clare, Seal, Sheila, Mannermaa, Arto, Kallioniemi, Anne, Lindeman, Geoffrey J., Buys, Saundra S., Andrulis, Irene L., Radice, Paolo, Tondini, Carlo, Manoukian, Siranoush, Toland, Amanda E., Miron, Penelope, Weitzel, Jeffrey N., Domchek, Susan M., Poppe, Bruce, Claes, Kathleen B.M., Yannoukakos, Drakoulis, Concannon, Patrick, Bernstein, Jonine L., James, Paul A., Easton, Douglas F., Goldgar, David E., Hopper, John L., Rahman, Nazneen, Peterlongo, Paolo, Nevanlinna, Heli, King, Mary-Claire, Couch, Fergus J., Southey, Melissa C., Winqvist, Robert, Foulkes, William D., and Tischkowitz, Marc

Published
2014
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85. Smoking, Radiation Therapy, and Contralateral Breast Cancer Risk in Young Women.

Author

Reiner, Anne S, Watt, Gordon P, John, Esther M, Lynch, Charles F, Brooks, Jennifer D, Mellemkjær, Lene, Boice, John D, Knight, Julia A, Concannon, Patrick, Smith, Susan A, Liang, Xiaolin, Woods, Meghan, Shore, Roy, Malone, Kathleen E, Bernstein, Leslie, Group, The WECARE Study Collaborative, Bernstein, Jonine L, and WECARE Study Collaborative Group

Subjects
RESEARCH, RESEARCH methodology, CASE-control method, EVALUATION research, COMPARATIVE studies, SECONDARY primary cancer, BREAST, RESEARCH funding, SMOKING, BREAST tumors
Abstract

Evidence is mounting that cigarette smoking contributes to second primary contralateral breast cancer (CBC) risk. Whether radiation therapy (RT) interacts with smoking to modify this risk is unknown. In this multicenter, individually matched, case-control study, we examined the association between RT, smoking, and CBC risk. The study included 1521 CBC cases and 2212 controls with unilateral breast cancer, all diagnosed with first invasive breast cancer between 1985 and 2008 aged younger than 55 years. Absorbed radiation doses to contralateral breast regions were estimated with thermoluminescent dosimeters in tissue-equivalent anthropomorphic phantoms, and smoking history was collected by interview. Rate ratios (RRs) and 95% confidence intervals (CIs) for CBC risk were estimated by multivariable conditional logistic regression. There was no interaction between any measure of smoking with RT to increase CBC risk (eg, the interaction of continuous RT dose with smoking at first breast cancer diagnosis [ever/never]: RR = 1.00, 95% CI = 0.89 to 1.14; continuous RT dose with years smoked: RR = 1.00, 95% CI = 0.99 to 1.01; and continuous RT dose with lifetime pack-years: RR = 1.00, 95% CI = 0.99 to 1.01). There was no evidence that RT further increased CBC risk in young women with first primary breast cancer who were current smokers or had smoking history. [ABSTRACT FROM AUTHOR]

Published
2022
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86. Cohort profile – MSK radiation workers: a feasibility study to establish a deceased worker sub-cohort as part of a multicenter medical radiation worker component in the million person study of low-dose radiation health effects.

Author

Dauer, Lawrence T., Woods, Meghan, Miodownik, Daniel, Serencsits, Brian, Quinn, Brian, Bellamy, Michael, Yoder, Craig, Liang, Xiaolin, Boice Jr., John D., and Bernstein, Jonine

Subjects
MEDICAL personnel, RADIATION dosimetry, RADIATION protection, RADIATION, RADIATION exposure
Abstract

The National Council on Radiation Protection and Measurements (NCRP) is coordinating an expansive epidemiologic effort entitled the Million Person Study of Low-Dose Radiation Health Effects (MPS). Medical workers constitute the largest occupational radiation-exposed group whose doses are typically received gradually over time. A unique opportunity exists to establish an Institutional Review Board/Privacy Board (IRB/PB) approved, retrospective feasibility sub-cohort of diseased Memorial Sloan Kettering Cancer Center (MSK) medical radiation workers to reconstruct occupational/work history, estimate organ-specific radiation absorbed doses, and review existing publicly available records for mortality from cancer (including leukemia) and other diseases. Special emphasis will be placed on dose reconstruction approaches as a means to provide valid organ dose estimates that are as accurate and precise as possible based on the available data, and to allow proper evaluation of accompanying uncertainties. Such a study that includes validated dose measurements and information on radiation exposure conditions would significantly reduce dose uncertainties and provided greatly improved information on chronic low-dose risks. The feasibility sub-cohort will include deceased radiation workers from MSK who worked during the nearly seventy-year timeframe from 1946 through 2010 and were provided individual personal radiation dosimetry monitors. A feasibility assessment focused on obtaining records for about 25–30,000 workers, with over 124,000 annual doses, including personnel/work histories, specific dosimetry data, and appropriate information for epidemiologic mortality tracing will be conducted. MSK radiation dosimetry measurements have followed stringent protocols complying with strict worker protection standards in order to provide accurate dose information for radiation workers that include detailed records of work practices (including specific task exposure conditions, radiation type, energy, geometry, personal protective equipment usage, badge position, and missed doses), as well as recorded measurements. These dose measurements have been ascertained through a variety of techniques that have evolved over the years, from film badges to thermoluminescent dosimetry technology to optically stimulated luminescent methodologies. It is expected that individual total doses for the sub-cohort will have a broad range from <10 mSv to > =1000 mSv. MSK has pioneered the use of novel radiation diagnostic and therapeutic approaches over time (including initial work with x-rays, radium, and radon), with workplace safety in mind, resulting in a variety of radiation worker exposure scenarios. The results of this feasibility sub-cohort of deceased radiation workers, and associated lessons learned may potentially be applied to an expanded multicenter study of about 170,000 medical radiation worker component of the MPS. [ABSTRACT FROM AUTHOR]

Published
2022
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88. Variation of breast cancer risk among BRCA1/2 carriers

Author

Begg, Colin B., Haile, Robert W., Borg, Ake, Malone, Kathleen E., Cocannon, Patrick, Thomas, Duncan C., Langholz, Bryan, Bernstein, Leslie, Olsen, Jorgen H., Lynch, Charles F., Anton-Culver, Hoda, Capanu, Marinela, Xiaolin, Liang, Hummer, Amanda J., Sima, Cami, and Bernstein, Jonine L.

Subjects
Breast cancer -- Risk factors, Breast cancer -- Genetic aspects, Mutation (Biology) -- Research, Population genetics -- Research
Abstract

A study to examine the degree of breast cancer risk among individuals who were carriers of the BRC1 and BRC 2 mutated genes is conducted. Results show that definite variations existed in the incidence of carriers developing unilateral or contralateral breast cancer when carrying the mentioned genes.

Published
2008

90. List of Contributors

Author

Abusief, Mary E., primary, Acevedo-Garcia, Dolores, additional, Albert, Christine, additional, Lee Alekel, D., additional, Alemany, Laia, additional, Allen, Kelli D., additional, Anderson, Lauren M., additional, Apelberg, Benjamin J., additional, Atrash, Hani K., additional, Baird, Donna Day, additional, Merz, Noel Bairey C., additional, Baldwin, Carol M., additional, Barbieri, Robert L., additional, Baron, Shirley R., additional, Bassuk, Shari S., additional, Bates, Lisa M., additional, Beasley, Jeannette M., additional, Bell, Iris R., additional, Bergeman, C.S., additional, Berkman, Lisa F., additional, Bernstein, Jonine L., additional, Bernstein, Leslie, additional, Bertone-Johnson, Elizabeth R., additional, Beth Thomeer, Mieke, additional, Bisconti, Toni L., additional, Blair, Janet, additional, Bonifas, Robin P., additional, Bosch, Xavier F., additional, Bradford, Judith, additional, Bray, Freddie, additional, Brooks, Jennifer D., additional, Bromberger, Joyce, additional, Brown, Joelle M., additional, Bruni, Laia, additional, Bulik, Cynthia M., additional, Burkman, Ronald T., additional, Burstein, Marcy, additional, Bushnell, Cheryl, additional, Buss, Mary K., additional, Cauley, Jane A., additional, Celum, Connie L., additional, Chen, Xinhua, additional, Chevarie-Davis, Myriam, additional, Chiuve, Stephanie, additional, Chocano-Bedoya, Patricia O., additional, Chowdhary, Harjinder, additional, Christiani, David C., additional, Chung, Nadia T., additional, Clancy, Carolyn M., additional, Clark, Cari Jo, additional, Conen, David, additional, Costenbader, K.H., additional, Devlin, Amy, additional, Diaz, Mireia, additional, Douwes, Jeroen, additional, Drangsholt, Mark, additional, Driscoll, Ira, additional, DuBeau, Catherine E., additional, Edwards, Emmeline, additional, Ehrenstein, Vera, additional, Escalante, Agustín, additional, Espeland, Mark A., additional, Fitzgerald, Kathryn C., additional, Foxman, Betsy, additional, Franco, Eduardo, additional, Fraser, William D., additional, Fredriksen-Goldsen, Karen I., additional, Freeman, Ellen E., additional, Friesen, Melissa C., additional, Gadermann, Anne M., additional, Gaudet, Mia M., additional, Gavrilidis, Emmy, additional, Gaydos, Charlotte A, additional, Geronimo, Kimberly, additional, Geronimus, Arline T., additional, Gillespie, Robin Mary, additional, Giovannucci, Edward, additional, Glanz, Karen, additional, Glynn, Robert J., additional, Gold, Ellen, additional, Goldfarb, Shari, additional, Goldman, Marlene B., additional, Gower, Emily W., additional, Grainger, David A., additional, Green, Adèle C., additional, Haggerty, Catherine L., additional, Hardy, Rebecca, additional, Harlow, Bernard L., additional, Harlow, Siobán D., additional, Hartge, Patricia, additional, Haskin, Christine, additional, Herbert, Robin, additional, Holt, Victoria L., additional, Hoover, Robert N., additional, Houtchens, Maria K., additional, Husten, Corinne G., additional, Hwang, Loris Y., additional, Hynes, Noreen A., additional, James, Peter, additional, Jewell, Elizabeth, additional, Johnson, Susan K., additional, Joshi, Pamela, additional, Joshu, Corinne E., additional, Kamb, Mary L., additional, Karvonen-Gutierrez, Carrie, additional, Kessler, Ronald C., additional, Khandker, Maheruh, additional, Khoury, Samia J., additional, Klein, Autumn M., additional, Koloski, Natasha A., additional, Kuh, Diana, additional, Kulkarni, Jayashri, additional, Kuller, Lewis H., additional, Lacey, James V., additional, LaCroix, Andrea Z., additional, Laden, Francine, additional, Lash, Timothy L., additional, Laughlin-Tommaso, Shannon K., additional, Lee, Cathy C., additional, Lee, Ji Youn, additional, Lee, Stephanie L., additional, LeResche, Linda, additional, Leveille, Suzanne G., additional, Lewis, Jannet F., additional, Lin, Frank R., additional, Tessler Lindau, Stacy, additional, Lindbohm, Marja-Liisa, additional, Liu, Simin, additional, Lloyd-Jones, Donald M., additional, Lortet-Tieulent, Joannie, additional, Lucas, Andrea, additional, Mackey, Rachel H., additional, Mager Stellman, Jeanne, additional, Malarcher, Ann Marie, additional, Manson, JoAnn E., additional, Margesson, Lynette J., additional, Maria Glymour, M., additional, Marrazzo, Jeanne M., additional, Matthews, Karen, additional, Mazzeo, Suzanne E., additional, McCarthy, Ellen P., additional, McCormack, Valerie, additional, McElrath, Thomas F., additional, McMaster, Romy-Leigh, additional, McTigue, Kathleen M., additional, Merikangas, Kathleen Ries, additional, Merz, C. Noel Bairey, additional, Messing, Karen, additional, Miller, Anthony B., additional, Mishell, Daniel R., additional, Missmer, Stacey A., additional, Mobley, Connie, additional, Moscicki, Anna-Barbara, additional, Muffly, Tyler, additional, Muzny, Christina A., additional, Nelson, Amanda E., additional, Nelson, Toben F., additional, O’Dell, Katharine K., additional, Olsen, Catherine M., additional, Olson, Sara H., additional, Osypuk, Theresa L., additional, Palmer, Julie R., additional, Paramsothy, Pangaja, additional, Parke, Ann L., additional, Patrick, Heather, additional, Paulus, Jessica K., additional, Paxton, Lynn, additional, Pearce, Neil, additional, Perti, Tara, additional, Pitzer, Lindsay, additional, Platz, Elizabeth A., additional, Potischman, Nancy, additional, Punnett, Laura, additional, Ramsey-Goldman, Rosalind, additional, Ranji, Usha, additional, Rastogi, Radhai M., additional, Reckelhoff, Jane F., additional, Resnick, Barbara, additional, Rexrode, Kathryn M., additional, Rigterink, Ellen S., additional, Rillamas-Sun, Eileen, additional, Robinson, Cara A., additional, Robinson, Jennifer G., additional, Robson, Mark E., additional, Rompalo, Anne M., additional, Saftlas, Audrey F., additional, Salganicoff, Alina, additional, Sallmén, Markku, additional, Sanjosé, Silvia de, additional, Sarto, Gloria E., additional, Sass, Samantha, additional, Savage, Sharon A., additional, Schildkraut, Joellen, additional, Schmaling, Karen, additional, Schmitz, Anja, additional, Scholl, Theresa O., additional, Schwebke, Jane R., additional, Scott, Stacey B., additional, Seedat, Soraya, additional, Seeman, Mary V., additional, Seow, Adeline, additional, Shah, Rashmee U., additional, Collins Sharp, Beth A., additional, Shin, Hai-Rim, additional, Shoupe, Donna, additional, Silverman, Debra T., additional, Snow, Rachel C., additional, Sophia, Eglacy C., additional, Sowers, MaryFran R., additional, Spaderna, Heike, additional, Stahre, Mandy, additional, Stewart, Elizabeth G., additional, Stuenkel, Cynthia A., additional, Stussman, Barbara, additional, Suliman, Sharain, additional, Talley, Nicholas J., additional, Taskinen, Helena, additional, Tatpati, Laura L., additional, Thomeer, Mieke Beth, additional, Titus, Linda J., additional, Tjaden, Bruce L., additional, Trabert, Britton, additional, Trace, Sara E., additional, Traverse, William, additional, Troisi, Rebecca, additional, Troped, Philip J., additional, Umberson, Debra, additional, Upson, Kristen, additional, Wagenen, Aimee Van, additional, Wald, Anna, additional, Wang, James K.C., additional, Ward, Mary H., additional, Wei, Shu-Qin, additional, Weidner, Gerdi, additional, Wentzensen, Nicolas, additional, Whiteside, James L., additional, Williams, Kristi, additional, Windham, Gayle C., additional, Wiringa, Ann E., additional, Wise, Lauren A., additional, Wofford, Marion, additional, Wu, Anna H., additional, Yaffe, Kristine, additional, Yang, Frances M., additional, Yunus, Muhammad B., additional, Zahm, Shelia Hoar, additional, Zera, Chloe A., additional, and Zilberman, Monica L., additional

Published
2013
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91. A case-control study of the joint effect of reproductive factors and radiation treatment for first breast cancer and risk of contralateral breast cancer in the WECARE study

Author

Brooks, Jennifer D., primary, Boice, John D., additional, Shore, Roy E., additional, Reiner, Anne S., additional, Smith, Susan A., additional, Bernstein, Leslie, additional, Knight, Julia A., additional, Lynch, Charles F., additional, John, Esther M., additional, Malone, Kathleen E., additional, Mellemkjaer, Lene, additional, Langballe, Rikke, additional, Liang, Xiaolin, additional, Woods, Meghan, additional, Tischkowitz, Marc, additional, Concannon, Patrick, additional, Stram, Daniel O., additional, and Bernstein, Jonine L., additional

Published
2020
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93. The emergence of networks in human genome epidemiology: challenges and opportunities

Author

Seminara, Daniela, primary, Khoury, Muin J., additional, O’Brien, Thomas R., additional, Manolio, Teri, additional, Gwinn, Marta, additional, Little, Julian, additional, Higgins, Julian P. T., additional, Bernstein, Jonine L., additional, Boffetta, Paolo, additional, Bondy, Melissa L., additional, Bray, Molly S., additional, Brenchley, Paul E., additional, Buffler, Patricia A., additional, Casas, Juan Pablo, additional, Chokkalingam, Anand P., additional, Danesh, John, additional, Smith, George Davey, additional, Dolan, Siobhan M., additional, Duncan, Ross, additional, Gruis, Nelleke A., additional, Hashibe, Mia, additional, Hunter, David J., additional, Jarvelin, Marjo-Riitta, additional, Malmer, Beatrice, additional, Maraganore, Demetrius M., additional, Newton-Bishop, Julia A., additional, Riboli, Elio, additional, Salanti, Georgia, additional, Taioli, Emanuela, additional, Timpson, Nic, additional, Uitterlinden, André G., additional, Vineis, Paolo, additional, Wareham, Nick, additional, Winn, Deborah M., additional, Zimmern, Ron, additional, and Ioannidis, John P. A., additional

Published
2009
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94. Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases

Author

Khoury, Muin J., primary, Bertram, Lars, additional, Boffetta, Paolo, additional, Butterworth, Adam S., additional, Chanock, Stephen J., additional, Dolan, Siobhan M., additional, Fortier, Isabel, additional, Garcia-Closas, Montserrat, additional, Gwinn, Marta, additional, Higgins, Julian P. T., additional, Janssens, A. Cecile J. W., additional, Ostell, James M., additional, Owen, Ryan P., additional, Pagon, Roberta A., additional, Rebbeck, Timothy R., additional, Rothman, Nathaniel, additional, Bernstein, Jonine L., additional, Burton, Paul R., additional, Campbell, Harry, additional, Chokkalingam, Anand P., additional, Furberg, Helena, additional, Little, Julian, additional, O’Brien, Thomas R., additional, Seminara, Daniela, additional, Vineis, Paolo, additional, Winn, Deborah M., additional, Yu, Wei, additional, and Ioannidis, John P. A., additional

Published
2009
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97. Variants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE study

Author

Brooks, Jennifer D., Teraoka, Sharon N., Reiner, Anne S., Satagopan, Jaya M., Bernstein, Leslie, Thomas, Duncan C., Capanu, Marinela, Stovall, Marilyn, Smith, Susan A., Wei, Shan, Shore, Roy E., Boice, John D., Jr., Lynch, Charles F., Mellemkjær, Lene, Malone, Kathleen E., Liang, Xiaolin, Haile, Robert W., Concannon, Patrick, and Bernstein, Jonine L.

Published
2012
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98. Pathogenic ATM Mutations in Cancer and a Genetic Basis for Radiotherapeutic Efficacy

Author

Pitter, Kenneth L, primary, Casey, Dana L, additional, Lu, Yue C, additional, Hannum, Margaret, additional, Zhang, Zhigang, additional, Song, Xinmao, additional, Pecorari, Isabella, additional, McMillan, Biko, additional, Ma, Jennifer, additional, Samstein, Robert M, additional, Pei, Isaac X, additional, Khan, Atif J, additional, Braunstein, Lior Z, additional, Morris, Luc G T, additional, Barker, Christopher A, additional, Rimner, Andreas, additional, Alektiar, Kaled M, additional, Romesser, Paul B, additional, Crane, Christopher H, additional, Yahalom, Joachim, additional, Zelefsky, Michael J, additional, Scher, Howard I, additional, Bernstein, Jonine L, additional, Mandelker, Diana L, additional, Weigelt, Britta, additional, Reis-Filho, Jorge S, additional, Lee, Nancy Y, additional, Powell, Simon N, additional, Chan, Timothy A, additional, Riaz, Nadeem, additional, and Setton, Jeremy, additional

Published
2020
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100. Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families

Author

Yang, Xin, primary, Leslie, Goska, additional, Doroszuk, Alicja, additional, Schneider, Sandra, additional, Allen, Jamie, additional, Decker, Brennan, additional, Dunning, Alison M., additional, Redman, James, additional, Scarth, James, additional, Plaskocinska, Inga, additional, Luccarini, Craig, additional, Shah, Mitul, additional, Pooley, Karen, additional, Dorling, Leila, additional, Lee, Andrew, additional, Adank, Muriel A., additional, Adlard, Julian, additional, Aittomäki, Kristiina, additional, Andrulis, Irene L., additional, Ang, Peter, additional, Barwell, Julian, additional, Bernstein, Jonine L., additional, Bobolis, Kristie, additional, Borg, Åke, additional, Blomqvist, Carl, additional, Claes, Kathleen B.M., additional, Concannon, Patrick, additional, Cuggia, Adeline, additional, Culver, Julie O., additional, Damiola, Francesca, additional, de Pauw, Antoine, additional, Diez, Orland, additional, Dolinsky, Jill S., additional, Domchek, Susan M., additional, Engel, Christoph, additional, Evans, D. Gareth, additional, Fostira, Florentia, additional, Garber, Judy, additional, Golmard, Lisa, additional, Goode, Ellen L., additional, Gruber, Stephen B., additional, Hahnen, Eric, additional, Hake, Christopher, additional, Heikkinen, Tuomas, additional, Hurley, Judith E., additional, Janavicius, Ramunas, additional, Kleibl, Zdenek, additional, Kleiblova, Petra, additional, Konstantopoulou, Irene, additional, Kvist, Anders, additional, Laduca, Holly, additional, Lee, Ann S.G., additional, Lesueur, Fabienne, additional, Maher, Eamonn R., additional, Mannermaa, Arto, additional, Manoukian, Siranoush, additional, McFarland, Rachel, additional, McKinnon, Wendy, additional, Meindl, Alfons, additional, Metcalfe, Kelly, additional, Mohd Taib, Nur Aishah, additional, Moilanen, Jukka, additional, Nathanson, Katherine L., additional, Neuhausen, Susan, additional, Ng, Pei Sze, additional, Nguyen-Dumont, Tu, additional, Nielsen, Sarah M., additional, Obermair, Florian, additional, Offit, Kenneth, additional, Olopade, Olufunmilayo I., additional, Ottini, Laura, additional, Penkert, Judith, additional, Pylkäs, Katri, additional, Radice, Paolo, additional, Ramus, Susan J., additional, Rudaitis, Vilius, additional, Side, Lucy, additional, Silva-Smith, Rachel, additional, Silvestri, Valentina, additional, Skytte, Anne-Bine, additional, Slavin, Thomas, additional, Soukupova, Jana, additional, Tondini, Carlo, additional, Trainer, Alison H., additional, Unzeitig, Gary, additional, Usha, Lydia, additional, van Overeem Hansen, Thomas, additional, Whitworth, James, additional, Wood, Marie, additional, Yip, Cheng Har, additional, Yoon, Sook-Yee, additional, Yussuf, Amal, additional, Zogopoulos, George, additional, Goldgar, David, additional, Hopper, John L., additional, Chenevix-Trench, Georgia, additional, Pharoah, Paul, additional, George, Sophia H.L., additional, Balmaña, Judith, additional, Houdayer, Claude, additional, James, Paul, additional, El-Haffaf, Zaki, additional, Ehrencrona, Hans, additional, Janatova, Marketa, additional, Peterlongo, Paolo, additional, Nevanlinna, Heli, additional, Schmutzler, Rita, additional, Teo, Soo-Hwang, additional, Robson, Mark, additional, Pal, Tuya, additional, Couch, Fergus, additional, Weitzel, Jeffrey N., additional, Elliott, Aaron, additional, Southey, Melissa, additional, Winqvist, Robert, additional, Easton, Douglas F., additional, Foulkes, William D., additional, Antoniou, Antonis C., additional, and Tischkowitz, Marc, additional

Published
2020
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