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52. Treatment of Oligometastatic Non-Small Cell Lung Cancer: An ASTRO/ESTRO Clinical Practice Guideline

Author

Iyengar, Puneeth, All, Sean, Berry, Mark F., Boike, Thomas P., Bradfield, Lisa, Dingemans, Anne-Marie C., Feldman, Jill, Gomez, Daniel R., Hesketh, Paul J., Jabbour, Salma K., Jeter, Melenda, Josipovic, Mirjana, Lievens, Yolande, McDonald, Fiona, Perez, Bradford A., Ricardi, Umberto, Ruffini, Enrico, De Ruysscher, Dirk, Saeed, Hina, Schneider, Bryan J., Senan, Suresh, Widder, Joachim, and Guckenberger, Matthias

Published
2023
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56. KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition

Author

Binkley, Michael S, Jeon, Young-Jun, Nesselbush, Monica, Moding, Everett J, Nabet, Barzin Y, Almanza, Diego, Kunder, Christian, Stehr, Henning, Yoo, Christopher H, Rhee, Siyeon, Xiang, Michael, Chabon, Jacob J, Hamilton, Emily, Kurtz, David M, Gojenola, Linda, Owen, Susie Grant, Ko, Ryan B, Shin, June Ho, Maxim, Peter G, Lui, Natalie S, Backhus, Leah M, Berry, Mark F, Shrager, Joseph B, Ramchandran, Kavitha J, Padda, Sukhmani K, Das, Millie, Neal, Joel W, Wakelee, Heather A, Alizadeh, Ash A, Loo, Billy W, and Diehn, Maximilian

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Lung, Cancer, Clinical Research, Lung Cancer, Biomarkers, Glutaminase, Humans, Kelch-Like ECH-Associated Protein 1, Lung Neoplasms, Mutation, NF-E2-Related Factor 2, Radiation Tolerance, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Tumor genotyping is not routinely performed in localized non-small cell lung cancer (NSCLC) due to lack of associations of mutations with outcome. Here, we analyze 232 consecutive patients with localized NSCLC and demonstrate that KEAP1 and NFE2L2 mutations are predictive of high rates of local recurrence (LR) after radiotherapy but not surgery. Half of LRs occurred in tumors with KEAP1/NFE2L2 mutations, indicating that they are major molecular drivers of clinical radioresistance. Next, we functionally evaluate KEAP1/NFE2L2 mutations in our radiotherapy cohort and demonstrate that only pathogenic mutations are associated with radioresistance. Furthermore, expression of NFE2L2 target genes does not predict LR, underscoring the utility of tumor genotyping. Finally, we show that glutaminase inhibition preferentially radiosensitizes KEAP1-mutant cells via depletion of glutathione and increased radiation-induced DNA damage. Our findings suggest that genotyping for KEAP1/NFE2L2 mutations could facilitate treatment personalization and provide a potential strategy for overcoming radioresistance conferred by these mutations. SIGNIFICANCE: This study shows that mutations in KEAP1 and NFE2L2 predict for LR after radiotherapy but not surgery in patients with NSCLC. Approximately half of all LRs are associated with these mutations and glutaminase inhibition may allow personalized radiosensitization of KEAP1/NFE2L2-mutant tumors.This article is highlighted in the In This Issue feature, p. 1775.

Published
2020

59. Organised crime in Red City : an ethnographic study of drugs, vice and violence

Author

Berry, Mark

Subjects
364.1, H Social Sciences (General)
Abstract

Illegal drug trafficking and retail drug sales constitute the most common activity of organised crime groups in the UK and draw the largest share of resources from the police and prison services, whilst also generating considerable social costs. There are few contemporary studies in the UK on the supply of drugs, its organisation, culture and risk management practices, and even fewer on active dealers themselves. There remains limited ethnographic research into the drug trade, missing important insights that can be gained from observing distributors in a natural setting. A key absence in criminological literature is the voice of offenders who commit serious crimes and how they perceive and mitigate problems related to their activities. This research aims to fill gaps in the knowledge base by investigating the nature of the drug market, the crime risk management practices of drug dealers, and possible reasons for their involvement and patterns of activity. The study examines the criminal careers of offenders who operate in one of Britain’s largest cities, termed here anonymously as Red City. The participants in this study distribute and manufacture a range of illicit substances, both offline and online. They distribute drugs on local, national and international levels (retail, wholesale, import and export). To complement the fieldwork, interviews were conducted with official actors from the criminal justice system, the private sector and the third sector. The thesis seeks to provide a more nuanced and grounded picture of illicit drug dealing and ‘organised crime’, that provides an account that corrects popular stereotypes. The chapters proceed as follows: Outline of the thesis: Chapter one provides the introduction to the thesis. It identifies the research problem, sets the contexts of the study and explains how the thesis contributes to the field. Chapter two outlines the theoretical framework for the thesis; it combines life course criminology with perspectives taken from research on organised crime. It examines organised crime in terms of markets, networks, and organisations. Chapter three describes the methodological approach employed in this study and considers the ethical and practical challenges of researching illegal activity. Chapter four addresses the ‘start’ of the criminal career when actors first become drug dealers. It follows the lives of the ‘lads’, who make up a core of the participants in the study. Chapter five examines how drug dealing is conducted in the city streets. It draws upon ethnographic data from two parallel drug markets that sit at opposite ends of the spectrum in terms of their harms and ‘legitimacy’. Chapter six provides a sociohistorical analysis of organised crime in the nightclub scene to the present day. It draws upon insights from bouncers and drug dealers working in the field. Chapter seven addresses the effects of emergent technology in the drug trade. It examines how offenders employ digital technologies, both offline and online. Chapter eight addresses the desistance phase in the life-course. It discusses the factors that facilitate and inhibit desistance for individuals and groups of offenders. Chapter nine outlines and evaluates the key findings in the thesis. It makes policy recommendations to mitigate problems related to drugs and organised crime in the future. Throughout all chapters of the analysis, comparisons are made between offenders working in different drug markets and settings, to assess the relationship between their activities and the characteristics of the marketplace in question. The study finds that drug markets that are closest to ‘legitimacy’, in terms of their legal status and the public perception of the drugs, can have less risks for distributors. In light of this, they may be sold more openly and accrue lower levels of exploitation in the trade. Overall, this thesis demonstrates how serious offenders operate in rapidly evolving criminal markets, providing a significant contribution to the knowledge base.

Published
2020

64. Greater ipsilateral rectus muscle atrophy after robotic thoracic surgery compared to open and Video-assisted thoracoscopic surgery approaches

Author

Wang, Yoyo, primary, Randle, Ryan J., additional, Bhandari, Prasha, additional, He, Hao, additional, Trope, Winston L., additional, Guenthart, Brandon A., additional, Guo, Haiwei H., additional, Liou, Douglas Z., additional, Backhus, Leah M., additional, Berry, Mark F., additional, Shrager, Joseph B., additional, and Lui, Natalie S., additional

Published
2024
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75. Population-Based Analysis of Local Therapies for Large (>7 cm) Non-Small Cell Lung Cancer Tumors.

Author

Patel, Deven C., Hao He, Liou, Douglas Z., Speicher, Paul J., and Berry, Mark F.

Subjects
PUBLIC health surveillance, PEARSON correlation (Statistics), SECONDARY analysis, T-test (Statistics), LOGISTIC regression analysis, FISHER exact test, RETROSPECTIVE studies, DESCRIPTIVE statistics, MULTIVARIATE analysis, KAPLAN-Meier estimator, STATISTICS, LUNG cancer, SURVIVAL analysis (Biometry), DATA analysis software, PROPORTIONAL hazards models
Abstract

OBJECTIVE: This study evaluated the impact of local treatment modalities in the management of large non-small cell lung cancer (NSCLC) tumors using a nationwide population-based dataset. MATERIAL AND METHODS: Patients with NSCLC tumors >7 cm that were cN0-1M0 in the Surveillance, Epidemiology, and End Results (SEER) registry from 2010 to 2015 were stratified by local management strategy (surgery, radiation therapy, no local treatment) and evaluated using Kaplan–Meier survival analyses, Cox proportional-hazard methods, and propensity-matched analysis. RESULTS: A total of 3156 patients were identified, of which 1580 (50.1%) underwent surgical resection, 920 (29.2%) received radiation only, 655 (20.7%) received no local treatment. Overall, the 5-year survival of patients undergoing surgical resection was 40.7%, compared to 14.7% and 5.3% for the radiation only and no local treatment groups, respectively (P < .001). Surgery with or without radiation continued to have an independent association with improved survival in multivariable analysis (HR 0.23, P < .0001). Other factors associated with improved survival included younger age, negative nodal disease, and chemotherapy use. In propensity-matched sub-analyses, 5-year survival remained significantly better after surgery alone compared to radiation alone (38.5% vs. 13.6%, P < .001), while survival after radiation alone was better than no local treatment, though both were largely poor (12.4% vs. 7.5%, P < .001). CONCLUSIONS: Survival of patients with large NSCLC managed non-surgically is very poor. Despite the significant long-term survival benefit with surgical intervention, nearly half of the study cohort did not undergo surgery. Patients and clinicians can use these results to estimate specific potential benefits when considering possible treatment strategies for large NSCLC tumors. [ABSTRACT FROM AUTHOR]

Published
2024
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88. Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation

Author

Miller, Marissa A., Taddei-Peters, Wendy C., Buxton, Dennis, Caulder, Ron, Geller, Nancy L., Gordon, David, Jeffries, Neal O., Lee, Albert, Moy, Claudia S., Gombos, Ilana Kogan, Ralph, Jennifer, Weisel, Richard D., Gardner, Timothy J., O’Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Chang, Helena, Chase, Melissa, Foo, James, Chen, Yingchun, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Dobrev, Edlira, Levitan, Ron, O’Sullivan, Karen, Overbey, Jessica, Santos, Milerva, Williams, Deborah, Weglinski, Michael, Williams, Paula, Wood, Carrie, Ye, Xia, Nielsen, Sten Lyager, Wiggers, Henrik, Malgaard, Henning, Mack, Michael, Adame, Tracine, Settele, Natalie, Adams, Jenny, Ryan, William, Smith, Robert L., Grayburn, Paul, Chen, Frederick Y., Nohria, Anju, Cohn, Lawrence, Shekar, Prem, Aranki, Sary, Couper, Gregory, Davidson, Michael, Bolman, R. Morton, III, Burgess, Anne, Conboy, Debra, Lawrence, Rita, Noiseux, Nicolas, Stevens, Louis-Mathieu, Prieto, Ignacio, Basile, Fadi, Dionne, Joannie, Fecteau, Julie, Blackstone, Eugene H., Gillinov, A. Marc, Lackner, Pamela, Berroteran, Leoma, Dolney, Diana, Fleming, Suzanne, Palumbo, Roberta, Whitman, Christine, Sankovic, Kathy, Sweeney, Denise Kosty, Geither, Carrie, Doud, Kristen, Pattakos, Gregory, Clarke, Pamela A., Argenziano, Michael, Williams, Mathew, Goldsmith, Lyn, Smith, Craig R., Naka, Yoshifumi, Stewart, Allan, Schwartz, Allan, Bell, Daniel, Van Patten, Danielle, Sreekanth, Sowmya, Smith, Peter K., Alexander, John H., Milano, Carmelo A., Glower, Donald D., Mathew, Joseph P., Harrison, J. Kevin, Welsh, Stacey, Berry, Mark F., Parsa, Cyrus J., Tong, Betty C., Williams, Judson B., Ferguson, T. Bruce, Kypson, Alan P., Rodriguez, Evelio, Harris, Malissa, Akers, Brenda, O'Neal, Allison, Puskas, John D., Thourani, Vinod H., Guyton, Robert, Baer, Jefferson, Baio, Kim, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, O’Connor, Kim, Dussault, Gladys, Ballivian, Tatiana, Keilani, Suzanne, Speir, Alan M., Magee, Patrick, Ad, Niv, Keyte, Sally, Dang, Minh, Slaughter, Mark, Headlee, Marsha, Moody, Heather, Solankhi, Naresh, Birks, Emma, Groh, Mark A., Shell, Leslie E., Shepard, Stephanie A., Trichon, Benjamin H., Nanney, Tracy, Hampton, Lynne C., Mangusan, Ralph, Michler, Robert E., D'Alessandro, David A., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo, Jakobleff, William, Garcia, Mario, Taub, Cynthia, Spevak, Daniel, Swayze, Roger, Sookraj, Nadia, Perrault, Louis P., Basmadjian, Arsène-Joseph, Bouchard, Denis, Carrier, Michel, Cartier, Raymond, Pellerin, Michel, Tanguay, Jean François, El-Hamamsy, Ismail, Denault, André, Demers, Philippe, Jonathan Lacharité, Sophie Robichaud, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Sai-Sudhakar, Chittoor, Hasan, Ayseha, McDavid, Asia, Kinn, Bradley, Pagé, Pierre, Sirois, Carole, Latter, David, Leong-Poi, Howard, Bonneau, Daniel, Errett, Lee, Peterson, Mark D., Verma, Subodh, Feder-Elituv, Randi, Cohen, Gideon, Joyner, Campbell, Fremes, Stephen E., Moussa, Fuad, Christakis, George, Karkhanis, Reena, Yau, Terry, Farkouh, Michael, Woo, Anna, Cusimano, Robert James, David, Tirone, Feindel, Christopher, Garrard, Lisa, Fredericks, Suzanne, Mociornita, Amelia, Mullen, John C., Choy, Jonathan, Meyer, Steven, Kuurstra, Emily, Gammie, James S., Young, Cindi A., Beach, Dana, Villanueva, Robert, Acker, Michael A., Atluri, Pavan, Woo, Y. Joseph, Mayer, Mary Lou, Bowdish, Michael, Starnes, Vaughn A., Shavalle, David, Matthews, Ray, Javadifar, Shadi, Romar, Linda, Kron, Irving L., Ailawadi, Gorav, Johnston, Karen, Dent, John M., Kern, John, Keim, Jessica, Burks, Sandra, Gahring, Kim, Bull, David A., Desvigne-Nickens, Patrice, Dixon, Dennis O., Haigney, Mark, Holubkov, Richard, Jacobs, Alice, Miller, Frank, Murkin, John M., Spertus, John, Wechsler, Andrew S., Sellke, Frank, McDonald, Cheryl L., Byington, Robert, Dickert, Neal, Ikonomidis, John S., Williams, David O., Yancy, Clyde W., Fang, James C., Giannetti, Nadia, Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Pinney, Sean, Roberts, William C., Walsh, Mary N., Hung, Judy, Zeng, Xin, Kilcullen, Niamh, Hung, David, Keteyian, Stephen J., Brawner, Clinton A., Aldred, Heather, Browndyke, Jeffrey, Toulgoat-Dubois, Yanne, Bertrand, Philippe B., Overbey, Jessica R., Levine, Robert A., Mack, Michael J., Giustino, Gennaro, and Bowdish, Michael E.

Published
2021
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92. ACR Appropriateness Criteria® Blunt Chest Trauma-Suspected Cardiac Injury

Author

Stojanovska, Jadranka, Hurwitz Koweek, Lynne M., Chung, Jonathan H., Ghoshhajra, Brian B., Walker, Christopher M., Beache, Garth M., Berry, Mark F., Colletti, Patrick M., Davis, Andrew M., Hsu, Joe Y., Khosa, Faisal, Kicska, Gregory A., Kligerman, Seth J., Litmanovich, Diana, Maroules, Christopher D., Meyersohn, Nandini, Syed, Mushabbar A., Tong, Betty C., Villines, Todd C., Wann, Samuel, Wolf, Stephen J., Kanne, Jeffrey P., and Abbara, Suhny

Published
2020
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94. Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation

Author

Miller, Marissa A., Taddei-Peters, Wendy C., Buxton, Dennis, Caulder, Ron, Geller, Nancy L., Gordon, David, Jeffries, Neal O., Lee, Albert, Moy, Claudia S., Gombos, Ilana Kogan, Ralph, Jennifer, Weisel, Richard, Gardner, Timothy J., O'Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Chang, Helena, Chase, Melissa, Chen, Yingchun, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Dobrev, Edlira, Levitan, Ron, O'Sullivan, Karen, Overbey, Jessica, Santos, Milerva, Weglinski, Michael, Williams, Paula, Wood, Carrie, Ye, Xia, Nielsen, Sten Lyager, Wiggers, Henrik, Malgaard, Henning, Mack, Michael, Adame, Tracine, Settele, Natalie, Adams, Jenny, Ryan, William, Smith, Robert L., Grayburn, Paul, Chen, Frederick Y., Nohria, Anju, Cohn, Lawrence, Shekar, Prem, Aranki, Sary, Couper, Gregory, Davidson, Michael, Bolman, R. Morton, III, Burgess, Anne, Conboy, Debra, Noiseux, Nicolas, Stevens, Louis-Mathieu, Prieto, Ignacio, Basile, Fadi, Dionne, Joannie, Fecteau, Julie, Blackstone, Eugene H., Gillinov, A. Marc, Lackner, Pamela, Berroteran, Leoma, Dolney, Diana, Fleming, Suzanne, Palumbo, Roberta, Whitman, Christine, Sankovic, Kathy, Sweeney, Denise Kosty, Pattakos, Gregory, Clarke, Pamela A., Argenziano, Michael, Williams, Mathew, Goldsmith, Lyn, Smith, Craig R., Naka, Yoshifumi, Stewart, Allan, Schwartz, Allan, Bell, Daniel, Van Patten, Danielle, Sreekanth, Sowmya, Smith, Peter K., Alexander, John H., Milano, Carmelo A., Glower, Donald D., Mathew, Joseph P., Harrison, J. Kevin, Welsh, Stacey, Berry, Mark F., Parsa, Cyrus J., Tong, Betty C., Williams, Judson B., Ferguson, T. Bruce, Kypson, Alan P., Rodriguez, Evelio, Harris, Malissa, Akers, Brenda, O'Neal, Allison, Puskas, John D., Thourani, Vinod H., Guyton, Robert, Baer, Jefferson, Baio, Kim, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, O'Connor, Kim, Dussault, Gladys, Ballivian, Tatiana, Keilani, Suzanne, Speir, Alan M., Magee, Patrick, Ad, Niv, Keyte, Sally, Dang, Minh, Slaughter, Mark, Headlee, Marsha, Moody, Heather, Solankhi, Naresh, Birks, Emma, Groh, Mark A., Shell, Leslie E., Shepard, Stephanie A., Trichon, Benjamin H., Nanney, Tracy, Hampton, Lynne C., Michler, Robert E., D'Alessandro, David A., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo, Jakobleff, William, Garcia, Mario, Taub, Cynthia, Spevak, Daniel, Swayze, Roger, Perrault, Louis P., Basmadjian, Arsène-Joseph, Bouchard, Denis, Carrier, Michel, Cartier, Raymond, Pellerin, Michel, Tanguay, Jean François, El-Hamamsy, Ismail, Denault, André, Demers, Philippe, Robichaud, Sophie, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Sai-Sudhakar, Chittoor, Hasan, Ayseha, McDavid, Asia, Kinn, Bradley, Pagé, Pierre, Sirois, Carole, Latter, David, Leong-Poi, Howard, Bonneau, Daniel, Errett, Lee, Peterson, Mark D., Verma, Subodh, Feder-Elituv, Randi, Cohen, Gideon, Joyner, Campbell, Fremes, Stephen E., Moussa, Fuad, Christakis, George, Karkhanis, Reena, Yau, Terry, Farkouh, Michael, Woo, Anna, Cusimano, Robert James, David, Tirone, Feindel, Christopher, Garrard, Lisa, Fredericks, Suzanne, Mociornita, Amelia, Mullen, John C., Choy, Jonathan, Meyer, Steven, Kuurstra, Emily, Gammie, James S., Young, Cindi A., Beach, Dana, Acker, Michael A., Atluri, Pavan, Woo, Y. Joseph, Mayer, Mary Lou, Bowdish, Michael, Starnes, Vaughn A., Shavalle, David, Matthews, Ray, Javadifar, Shadi, Romar, Linda, Kron, Irving L., Ailawadi, Gorav, Johnston, Karen, Dent, John M., Kern, John, Keim, Jessica, Burks, Sandra, Gahring, Kim, Bull, David A., Desvigne-Nickens, Patrice, Dixon, Dennis O., Haigney, Mark, Holubkov, Richard, Jacobs, Alice, Miller, Frank, Murkin, John M., Spertus, John, Wechsler, Andrew S., Sellke, Frank, McDonald, Cheryl L., Byington, Robert, Dickert, Neal, Ikonomidis, John S., Williams, David O., Yancy, Clyde W., Fang, James C., Giannetti, Nadia, Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Pinney, Sean, Roberts, William C., Walsh, Mary N., Keteyian, Stephen J., Brawner, Clinton A., Aldred, Heather, Hung, Judy, Zeng, Xin, Browndyke, Jeffrey, Toulgoat-Dubois, Yanne, Ferket, Bart S., Hohmann, Samuel F., Chang, Helena L., Mick, Stephanie L., Hung, Judy W., Overbey, Jessica R., and Lala, Anuradha

Published
2020
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95. ACR Appropriateness Criteria® Hemoptysis

Author

Olsen, Kathryn M., Manouchehr-pour, Shawdi, Donnelly, Edwin F., Henry, Travis S., Berry, Mark F., Boiselle, Phillip M., Colletti, Patrick M., Harrison, Nicholas E., Kuzniewski, Christopher T., Laroia, Archana T., Maldonado, Fabien, Pinchot, Jason W., Raptis, Constantine A., Shim, Kyungran, Tong, Betty C., Wu, Carol C., and Kanne, Jeffrey P.

Published
2020
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96. ACR Appropriateness Criteria® Occupational Lung Diseases

Author

Cox, Christian W., Chung, Jonathan H., Ackman, Jeanne B., Berry, Mark F., Carter, Brett W., de Groot, Patricia M., Hobbs, Stephen B., Johnson, Geoffrey B., Maldonado, Fabien, McComb, Barbara L., Tong, Betty C., Walker, Christopher M., and Kanne, Jeffrey P.

Published
2020
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99. Deep learning-based denoising streamed from mobile phones improves speech-in-noise understanding for hearing aid users

Author

Diehl, Peter Udo, primary, Zilly, Hannes, additional, Sattler, Felix, additional, Singer, Yosef, additional, Kepp, Kevin, additional, Berry, Mark, additional, Hasemann, Henning, additional, Zippel, Marlene, additional, Kaya, Müge, additional, Meyer-Rachner, Paul, additional, Pudszuhn, Annett, additional, Hofmann, Veit M., additional, Vormann, Matthias, additional, and Sprengel, Elias, additional

Published
2023
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