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51. Internet use by older adults with bipolar disorder:international survey results

Author

Bauer, Rita, Glenn, Tasha, Strejilevich, Sergio, Conell, Jörn, Alda, Martin, Ardau, Raffaella, Baune, Bernhard T., Berk, Michael, Bersudsky, Yuly, Bilderbeck, Amy, Bocchetta, Alberto, Castro, Angela M.Paredes, Cheung, Eric Y.W., Chillotti, Caterina, Choppin, Sabine, Cuomo, Alessandro, Del Zompo, Maria, Dias, Rodrigo, Dodd, Seetal, Duffy, Anne, Etain, Bruno, Fagiolini, Andrea, Fernández Hernandez, Miryam, Garnham, Julie, Geddes, John, Gildebro, Jonas, Gitlin, Michael J., Gonzalez-Pinto, Ana, Goodwin, Guy M., Grof, Paul, Harima, Hirohiko, Hassel, Stefanie, Henry, Chantal, Hidalgo-Mazzei, Diego, Lund, Anne Hvenegaard, Kapur, Vaisnvy, Kunigiri, Girish, Lafer, Beny, Larsen, Erik R., Lewitzka, Ute, Licht, Rasmus W., Misiak, Blazej, Piotrowski, Patryk, Miranda-Scippa, Ângela, Monteith, Scott, Munoz, Rodrigo, Nakanotani, Takako, Nielsen, René E., O’Donovan, Claire, Okamura, Yasushi, Osher, Yamima, Reif, Andreas, Ritter, Philipp, Rybakowski, Janusz K., Sagduyu, Kemal, Sawchuk, Brett, Schwartz, Elon, Slaney, Claire, Sulaiman, Ahmad H., Suominen, Kirsi, Suwalska, Aleksandra, Tam, Peter, Tatebayashi, Yoshitaka, Tondo, Leonardo, Veeh, Julia, Vieta, Eduard, Vinberg, Maj, Viswanath, Biju, Zetin, Mark, Whybrow, Peter C., Bauer, Michael, Bauer, Rita, Glenn, Tasha, Strejilevich, Sergio, Conell, Jörn, Alda, Martin, Ardau, Raffaella, Baune, Bernhard T., Berk, Michael, Bersudsky, Yuly, Bilderbeck, Amy, Bocchetta, Alberto, Castro, Angela M.Paredes, Cheung, Eric Y.W., Chillotti, Caterina, Choppin, Sabine, Cuomo, Alessandro, Del Zompo, Maria, Dias, Rodrigo, Dodd, Seetal, Duffy, Anne, Etain, Bruno, Fagiolini, Andrea, Fernández Hernandez, Miryam, Garnham, Julie, Geddes, John, Gildebro, Jonas, Gitlin, Michael J., Gonzalez-Pinto, Ana, Goodwin, Guy M., Grof, Paul, Harima, Hirohiko, Hassel, Stefanie, Henry, Chantal, Hidalgo-Mazzei, Diego, Lund, Anne Hvenegaard, Kapur, Vaisnvy, Kunigiri, Girish, Lafer, Beny, Larsen, Erik R., Lewitzka, Ute, Licht, Rasmus W., Misiak, Blazej, Piotrowski, Patryk, Miranda-Scippa, Ângela, Monteith, Scott, Munoz, Rodrigo, Nakanotani, Takako, Nielsen, René E., O’Donovan, Claire, Okamura, Yasushi, Osher, Yamima, Reif, Andreas, Ritter, Philipp, Rybakowski, Janusz K., Sagduyu, Kemal, Sawchuk, Brett, Schwartz, Elon, Slaney, Claire, Sulaiman, Ahmad H., Suominen, Kirsi, Suwalska, Aleksandra, Tam, Peter, Tatebayashi, Yoshitaka, Tondo, Leonardo, Veeh, Julia, Vieta, Eduard, Vinberg, Maj, Viswanath, Biju, Zetin, Mark, Whybrow, Peter C., and Bauer, Michael

Abstract

Background: The world population is aging and the number of older adults with bipolar disorder is increasing. Digital technologies are viewed as a framework to improve care of older adults with bipolar disorder. This analysis quantifies Internet use by older adults with bipolar disorder as part of a larger survey project about information seeking. Methods: A paper-based survey about information seeking by patients with bipolar disorder was developed and translated into 12 languages. The survey was anonymous and completed between March 2014 and January 2016 by 1222 patients in 17 countries. All patients were diagnosed by a psychiatrist. General estimating equations were used to account for correlated data. Results: Overall, 47% of older adults (age 60 years or older) used the Internet versus 87% of younger adults (less than 60 years). More education and having symptoms that interfered with regular activities increased the odds of using the Internet, while being age 60 years or older decreased the odds. Data from 187 older adults and 1021 younger adults were included in the analysis excluding missing values. Conclusions: Older adults with bipolar disorder use the Internet much less frequently than younger adults. Many older adults do not use the Internet, and technology tools are suitable for some but not all older adults. As more health services are only available online, and more digital tools are developed, there is concern about growing health disparities based on age. Mental health experts should participate in determining the appropriate role for digital tools for older adults with bipolar disorder.

Published
2018

53. International multi-site survey on the use of online support groups in bipolar disorder

Author

Bauer, Rita, primary, Conell, Jörn, additional, Glenn, Tasha, additional, Alda, Martin, additional, Ardau, Raffaella, additional, Baune, Bernhard T., additional, Berk, Michael, additional, Bersudsky, Yuly, additional, Bilderbeck, Amy, additional, Bocchetta, Alberto, additional, Bossini, Letizia, additional, Castro, Angela M. Paredes, additional, Cheung, Eric Y. W., additional, Chillotti, Caterina, additional, Choppin, Sabine, additional, Zompo, Maria Del, additional, Dias, Rodrigo, additional, Dodd, Seetal, additional, Duffy, Anne, additional, Etain, Bruno, additional, Fagiolini, Andrea, additional, Hernandez, Miryam Fernández, additional, Garnham, Julie, additional, Geddes, John, additional, Gildebro, Jonas, additional, Gonzalez-Pinto, Ana, additional, Goodwin, Guy M., additional, Grof, Paul, additional, Harima, Hirohiko, additional, Hassel, Stefanie, additional, Henry, Chantal, additional, Hidalgo-Mazzei, Diego, additional, Kapur, Vaisnvy, additional, Kunigiri, Girish, additional, Lafer, Beny, additional, Larsen, Erik R., additional, Lewitzka, Ute, additional, Licht, Rasmus W., additional, Hvenegaard Lund, Anne, additional, Misiak, Blazej, additional, Piotrowski, Patryk, additional, Monteith, Scott, additional, Munoz, Rodrigo, additional, Nakanotani, Takako, additional, Nielsen, René E, additional, O’donovan, Claire, additional, Okamura, Yasushi, additional, Osher, Yamima, additional, Reif, Andreas, additional, Ritter, Philipp, additional, Rybakowski, Janusz K., additional, Sagduyu, Kemal, additional, Sawchuk, Brett, additional, Schwartz, Elon, additional, Scippa, Ângela M, additional, Slaney, Claire, additional, Sulaiman, Ahmad H., additional, Suominen, Kirsi, additional, Suwalska, Aleksandra, additional, Tam, Peter, additional, Tatebayashi, Yoshitaka, additional, Tondo, Leonardo, additional, Vieta, Eduard, additional, Vinberg, Maj, additional, Viswanath, Biju, additional, Volkert, Julia, additional, Zetin, Mark, additional, Whybrow, Peter C., additional, and Bauer, Michael, additional

Published
2017
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55. International multi-site survey on the use of online support groups in bipolar disorder

Author

Bauer, Rita, Conell, Jörn, Glenn, Tasha, Alda, Martin, Ardau, Raffaella, Baune, Bernhard T., Berk, Michael, Bersudsky, Yuly, Bilderbeck, Amy, Bocchetta, Alberto, Bossini, Letizia, Paredes Castro, Angela M., Cheung, Eric Y.W., Chillotti, Caterina, Choppin, Sabine, Zompo, Maria Del, Dias, Rodrigo, Dodd, Seetal, Duffy, Anne, Etain, Bruno, Fagiolini, Andrea, Fernández Hernandez, Miryam, Garnham, Julie, Geddes, John, Gildebro, Jonas, Gonzalez-Pinto, Ana, Goodwin, Guy M., Grof, Paul, Harima, Hirohiko, Hassel, Stefanie, Henry, Chantal, Hidalgo-Mazzei, Diego, Kapur, Vaisnvy, Kunigiri, Girish, Lafer, Beny, Larsen, Erik R., Lewitzka, Ute, Licht, Rasmus W., Hvenegaard Lund, Anne, Misiak, Blazej, Piotrowski, Patryk, Monteith, Scott, Munoz, Rodrigo, Nakanotani, Takako, Nielsen, René E., O’Donovan, Claire, Okamura, Yasushi, Osher, Yamima, Reif, Andreas, Ritter, Philipp, Rybakowski, Janusz K., Sagduyu, Kemal, Sawchuk, Brett, Schwartz, Elon, Scippa, Ângela M., Slaney, Claire, Sulaiman, Ahmad H., Suominen, Kirsi, Suwalska, Aleksandra, Tam, Peter, Tatebayashi, Yoshitaka, Tondo, Leonardo, Vieta, Eduard, Vinberg, Maj, Viswanath, Biju, Volkert, Julia, Zetin, Mark, Whybrow, Peter C., Bauer, Michael, Bauer, Rita, Conell, Jörn, Glenn, Tasha, Alda, Martin, Ardau, Raffaella, Baune, Bernhard T., Berk, Michael, Bersudsky, Yuly, Bilderbeck, Amy, Bocchetta, Alberto, Bossini, Letizia, Paredes Castro, Angela M., Cheung, Eric Y.W., Chillotti, Caterina, Choppin, Sabine, Zompo, Maria Del, Dias, Rodrigo, Dodd, Seetal, Duffy, Anne, Etain, Bruno, Fagiolini, Andrea, Fernández Hernandez, Miryam, Garnham, Julie, Geddes, John, Gildebro, Jonas, Gonzalez-Pinto, Ana, Goodwin, Guy M., Grof, Paul, Harima, Hirohiko, Hassel, Stefanie, Henry, Chantal, Hidalgo-Mazzei, Diego, Kapur, Vaisnvy, Kunigiri, Girish, Lafer, Beny, Larsen, Erik R., Lewitzka, Ute, Licht, Rasmus W., Hvenegaard Lund, Anne, Misiak, Blazej, Piotrowski, Patryk, Monteith, Scott, Munoz, Rodrigo, Nakanotani, Takako, Nielsen, René E., O’Donovan, Claire, Okamura, Yasushi, Osher, Yamima, Reif, Andreas, Ritter, Philipp, Rybakowski, Janusz K., Sagduyu, Kemal, Sawchuk, Brett, Schwartz, Elon, Scippa, Ângela M., Slaney, Claire, Sulaiman, Ahmad H., Suominen, Kirsi, Suwalska, Aleksandra, Tam, Peter, Tatebayashi, Yoshitaka, Tondo, Leonardo, Vieta, Eduard, Vinberg, Maj, Viswanath, Biju, Volkert, Julia, Zetin, Mark, Whybrow, Peter C., and Bauer, Michael

Abstract

Background: Peer support is an established component of recovery from bipolar disorder, and online support groups may offer opportunities to expand the use of peer support at the patient’s convenience. Prior research in bipolar disorder has reported value from online support groups. Aims: To understand the use of online support groups by patients with bipolar disorder as part of a larger project about information seeking. Methods: The results are based on a one-time, paper-based anonymous survey about information seeking by patients with bipolar disorder, which was translated into 12 languages. The survey was completed between March 2014 and January 2016 and included questions on the use of online support groups. All patients were diagnosed by a psychiatrist. Analysis included descriptive statistics and general estimating equations to account for correlated data. Results and conclusions: The survey was completed by 1222 patients in 17 countries. The patients used the Internet at a percentage similar to the general public. Of the Internet users who looked online for information about bipolar disorder, only 21.0% read or participated in support groups, chats, or forums for bipolar disorder (12.8% of the total sample). Given the benefits reported in prior research, clarification of the role of online support groups in bipolar disorder is needed. With only a minority of patients using online support groups, there are analytical challenges for future studies.

Published
2017

56. Influence of light exposure during early life on the age of onset of bipolar disorder

Author

Bauer, Michael Glenn, Tasha Alda, Martin Andreassen, Ole A. and Angelopoulos, Elias Ardau, Raffaella Baethge, Christopher and Bauer, Rita Baune, Bernhard T. Bellivier, Frank and Belmaker, Robert H. Berk, Michael Bjella, Thomas D. Bossini, Letizia Bersudsky, Yuly Cheung, Eric Yat Wo Conell, Joern and Del Zompo, Maria Dodd, Seetal Etain, Bruno Fagiolini, Andrea Frye, Mark A. Fountoulakis, Kostas N. and Garneau-Fournier, Jade Gonzalez-Pinto, Ana Gottlieb, John F. and Harima, Hirohiko Hassel, Stefanie Henry, Chantal Iacovides, Apostolos Isometsa, Erkki T. Kapczinski, Flavio Kliwicki, Sebastian Koenig, Barbara Krogh, Rikke Kunz, Mauricio and Lafer, Beny Larsen, Erik R. Lewitzka, Ute Lopez-Jaramillo, Carlos MacQueen, Glenda Manchia, Mirko Marsh, Wendy and Martinez-Cengotitabengo, Monica Melle, Ingrid Monteith, Scott and Morken, Gunnar Munoz, Rodrigo Nery, Fabiano G. and O'Donovan, Claire Osher, Yamima Pfennig, Andrea Quiroz, Danilo Ramesar, Raj Rasgon, Natalie Reif, Andreas and Ritter, Philipp Rybakowski, Janusz K. Sagduyu, Kemal and Miranda-Scippa, Angela Severus, Emanuel Simhandl, Christian and Stein, Dan J. Strejilevich, Sergio Sulaiman, Ahmad Hatim and Suominen, Kirsi Tagata, Hiromi Tatebayashi, Yoshitaka and Torrent, Carla Vieta, Eduard Viswanath, Biju Wanchoo, Mihir J. Zetin, Mark Whybrow, Peter C.

Abstract

Background: Environmental conditions early in life may imprint the circadian system and influence response to environmental signals later in life. We previously determined that a large springtime increase in solar insolation at the onset location was associated with a younger age of onset of bipolar disorder, especially with a family history of mood disorders. This study investigated whether the hours of daylight at the birth location affected this association. Methods: Data collected previously at 36 collection sites from 23 countries were available for 3896 patients with bipolar I disorder, born between latitudes of 1.4 N and 70.7 N, and 1.2 S and 413 S. Hours of daylight variables for the birth location were added to a base model to assess. the relation between the age of onset and solar insolation. Results: More hours of daylight at the birth location during early life was associated with an older age of onset, suggesting reduced vulnerability to the future circadian challenge of the springtime increase in solar insolation at the onset location. Addition of the minimum of the average monthly hours of daylight during the first 3 months of life improved the base model, with a significant positive relationship to age of onset. Coefficients for all other variables remained stable, significant and consistent with the base model. Conclusions: Light exposure during early life may have important consequences for those who are susceptible to bipolar disorder, especially at latitudes with little natural light in winter. This study indirectly supports the concept that early life exposure to light may affect the long term adaptability to respond to a circadian challenge later in life. (C) 2015 Elsevier Ltd. All rights reserved.

Published
2015

57. Online information seeking by patients with bipolar disorder:results from an international multisite survey

Author

Conell, Jörn, Bauer, Rita, Glenn, Tasha, Alda, Martin, Ardau, Raffaella, Baune, Bernhard T., Berk, Michael, Bersudsky, Yuly, Bilderbeck, Amy, Bocchetta, Alberto, Bossini, Letizia, Paredes Castro, Angela Marianne, Cheung, Eric Yat Wo, Chillotti, Caterina, Choppin, Sabine, del Zompo, Maria, Dias, Rodrigo, Dodd, Seetal, Duffy, Anne, Etain, Bruno, Fagiolini, Andrea, Garnham, Julie, Geddes, John, Gildebro, Jonas, González-Pinto, Ana, Goodwin, Guy M., Grof, Paul, Harima, Hirohiko, Hassel, Stefanie, Henry, Chantal, Hidalgo-Mazzei, Diego, Kapur, Vaisnvy, Kunigiri, Girish, Lafer, Beny, Lam, Chun, Larsen, Erik Roj, Lewitzka, Ute, Licht, Rasmus, Lund, Anne Hvenegaard, Misiak, Blazej, Piotrowski, Patryk, Monteith, Scott, Munoz, Rodrigo, Nakanotani, Takako, Nielsen, René E., O’Donovan, Claire, Okamura, Yasushi, Osher, Yamima, Reif, Andreas, Ritter, Philipp, Rybakowski, Janusz K., Sagduyu, Kemal, Sawchuk, Brett, Schwartz, Elon, Scippa, Ângela Miranda, Slaney, Claire, Hatim Sulaiman, Ahmad, Suominen, Kirsi, Suwalska, Aleksandra, Tam, Peter, Tatebayashi, Yoshitaka, Tondo, Leonardo, Vieta, Eduard, Vinberg, Maj, Viswanath, Biju, Volkert, Julia, Zetin, Mark, Zorrilla, Iñaki, Whybrow, Peter C., Bauer, Michael, Conell, Jörn, Bauer, Rita, Glenn, Tasha, Alda, Martin, Ardau, Raffaella, Baune, Bernhard T., Berk, Michael, Bersudsky, Yuly, Bilderbeck, Amy, Bocchetta, Alberto, Bossini, Letizia, Paredes Castro, Angela Marianne, Cheung, Eric Yat Wo, Chillotti, Caterina, Choppin, Sabine, del Zompo, Maria, Dias, Rodrigo, Dodd, Seetal, Duffy, Anne, Etain, Bruno, Fagiolini, Andrea, Garnham, Julie, Geddes, John, Gildebro, Jonas, González-Pinto, Ana, Goodwin, Guy M., Grof, Paul, Harima, Hirohiko, Hassel, Stefanie, Henry, Chantal, Hidalgo-Mazzei, Diego, Kapur, Vaisnvy, Kunigiri, Girish, Lafer, Beny, Lam, Chun, Larsen, Erik Roj, Lewitzka, Ute, Licht, Rasmus, Lund, Anne Hvenegaard, Misiak, Blazej, Piotrowski, Patryk, Monteith, Scott, Munoz, Rodrigo, Nakanotani, Takako, Nielsen, René E., O’Donovan, Claire, Okamura, Yasushi, Osher, Yamima, Reif, Andreas, Ritter, Philipp, Rybakowski, Janusz K., Sagduyu, Kemal, Sawchuk, Brett, Schwartz, Elon, Scippa, Ângela Miranda, Slaney, Claire, Hatim Sulaiman, Ahmad, Suominen, Kirsi, Suwalska, Aleksandra, Tam, Peter, Tatebayashi, Yoshitaka, Tondo, Leonardo, Vieta, Eduard, Vinberg, Maj, Viswanath, Biju, Volkert, Julia, Zetin, Mark, Zorrilla, Iñaki, Whybrow, Peter C., and Bauer, Michael

Abstract

Background: Information seeking is an important coping mechanism for dealing with chronic illness. Despite a growing number of mental health websites, there is little understanding of how patients with bipolar disorder use the Internet to seek information. Methods: A 39 question, paper-based, anonymous survey, translated into 12 languages, was completed by 1222 patients in 17 countries as a convenience sample between March 2014 and January 2016. All patients had a diagnosis of bipolar disorder from a psychiatrist. Data were analyzed using descriptive statistics and generalized estimating equations to account for correlated data. Results: 976 (81 % of 1212 valid responses) of the patients used the Internet, and of these 750 (77 %) looked for information on bipolar disorder. When looking online for information, 89 % used a computer rather than a smartphone, and 79 % started with a general search engine. The primary reasons for searching were drug side effects (51 %), to learn anonymously (43 %), and for help coping (39 %). About 1/3 rated their search skills as expert, and 2/3 as basic or intermediate. 59 % preferred a website on mental illness and 33 % preferred Wikipedia. Only 20 % read or participated in online support groups. Most patients (62 %) searched a couple times a year. Online information seeking helped about 2/3 to cope (41 % of the entire sample). About 2/3 did not discuss Internet findings with their doctor. Conclusion: Online information seeking helps many patients to cope although alternative information sources remain important. Most patients do not discuss Internet findings with their doctor, and concern remains about the quality of online information especially related to prescription drugs. Patients may not rate search skills accurately, and may not understand limitations of online privacy. More patient education about online information searching is needed and physicians should recommend a few high quality websites.

Published
2016

58. Internet use by patients with bipolar disorder:results from an international multisite survey

Author

Bauer, Rita, Conell, Jörn, Glenn, Tasha, Alda, Martin, Ardau, Raffaella, Baune, Bernhard T., Berk, Michael, Bersudsky, Yuly, Bilderbeck, Amy, Bocchetta, Alberto, Bossini, Letizia, Paredes Castro, Angela M., Cheung, Eric YW., Chillotti, Caterina, Choppin, Sabine, del Zompo, Maria, Dias, Rodrigo, Dodd, Seetal, Duffy, Anne, Etain, Bruno, Fagiolini, Andrea, Fernández Hernandez, Miryam, Garnham, Julie, Geddes, John, Gildebro, Jonas, González-Pinto, Ana, Goodwin, Guy M., Grof, Paul, Harima, Hirohiko, Hassel, Stefanie, Henry, Chantal, Hidalgo-Mazzei, Diego, Kapur, Vaisnvy, Kunigiri, Girish, Lafer, Beny, Larsen, Erik R., Lewitzka, Ute, Licht, Rasmus W., Lund, Anne Hvenegaard, Misiak, Blazej, Monteith, Scott, Munoz, Rodrigo, Nakanotani, Takako, Nielsen, René E., O'Donovan, Claire, Okamura, Yasushi, Osher, Yamima, Piotrowski, Patryk, Reif, Andreas, Ritter, Philipp, Rybakowski, Janusz K., Sagduyu, Kemal, Sawchuk, Brett, Schwartz, Elon, Scippa, Ângela M., Slaney, Claire, Sulaiman, Ahmad H., Suominen, Kirsi, Suwalska, Aleksandra, Tam, Peter, Tatebayashi, Yoshitaka, Tondo, Leonardo, Vieta, Eduard, Vinberg, Maj, Viswanath, Biju, Volkert, Julia, Zetin, Mark, Whybrow, Peter C., Bauer, Michael, Bauer, Rita, Conell, Jörn, Glenn, Tasha, Alda, Martin, Ardau, Raffaella, Baune, Bernhard T., Berk, Michael, Bersudsky, Yuly, Bilderbeck, Amy, Bocchetta, Alberto, Bossini, Letizia, Paredes Castro, Angela M., Cheung, Eric YW., Chillotti, Caterina, Choppin, Sabine, del Zompo, Maria, Dias, Rodrigo, Dodd, Seetal, Duffy, Anne, Etain, Bruno, Fagiolini, Andrea, Fernández Hernandez, Miryam, Garnham, Julie, Geddes, John, Gildebro, Jonas, González-Pinto, Ana, Goodwin, Guy M., Grof, Paul, Harima, Hirohiko, Hassel, Stefanie, Henry, Chantal, Hidalgo-Mazzei, Diego, Kapur, Vaisnvy, Kunigiri, Girish, Lafer, Beny, Larsen, Erik R., Lewitzka, Ute, Licht, Rasmus W., Lund, Anne Hvenegaard, Misiak, Blazej, Monteith, Scott, Munoz, Rodrigo, Nakanotani, Takako, Nielsen, René E., O'Donovan, Claire, Okamura, Yasushi, Osher, Yamima, Piotrowski, Patryk, Reif, Andreas, Ritter, Philipp, Rybakowski, Janusz K., Sagduyu, Kemal, Sawchuk, Brett, Schwartz, Elon, Scippa, Ângela M., Slaney, Claire, Sulaiman, Ahmad H., Suominen, Kirsi, Suwalska, Aleksandra, Tam, Peter, Tatebayashi, Yoshitaka, Tondo, Leonardo, Vieta, Eduard, Vinberg, Maj, Viswanath, Biju, Volkert, Julia, Zetin, Mark, Whybrow, Peter C., and Bauer, Michael

Abstract

There is considerable international interest in online education of patients with bipolar disorder, yet little understanding of how patients use the Internet and other sources to seek information. 1171 patients with bipolar disorder diagnosis in 17 countries completed a paper-based, anonymous survey. 81% of the patients used the Internet, a percentage similar to the general public. Older age, less education, and challenges in country telecommunications infrastructure and demographics decreased the odds of using the Internet. About 78% of the Internet users looked online for information on bipolar disorder or 63% of the total sample. More years of education in relation to the country mean, and feeling very confident about managing life decreased the odds of seeking information on bipolar disorder online, while having attended support groups increased the odds. Patients who looked online for information on bipolar disorder consulted medical professionals plus a mean of 2.3 other information sources such as books, physician handouts, and others with bipolar disorder. Patients not using the Internet consulted medical professionals plus a mean of 1.6 other information sources. The percentage of patients with bipolar disorder who use the Internet is about the same as the general public. Other information sources remain important.

Published
2016

60. Relationship between sunlight and the age of onset of bipolar disorder: An international multisite study

Author

Bauer, Michael Glenn, Tasha Alda, Martin Andreassen, Ole A. and Angelopoulos, Elias Ardau, Raffaella Baethge, Christopher and Bauer, Rita Bellivier, Frank Belmaker, Robert H. Berk, Michael Bjella, Thomas D. Bossini, Letizia Bersudsky, Yuly and Cheung, Eric Yat Wo Conell, Jorn Del Zompo, Maria Dodd, Seetal Etain, Bruno Fagiolini, Andrea Frye, Mark A. and Fountoulakis, Kostas N. Garneau-Fournier, Jade Gonzalez-Pinto, Ana Harima, Hirohiko Hassel, Stefanie Henry, Chantal and Iacovides, Apostolos Isometsa, Erkki T. Kapczinski, Flavio and Kliwicki, Sebastian Koenig, Barbara Krogh, Rikke Kunz, Mauricio Lafer, Beny Larsen, Erik R. Lewitzka, Ute and Lopez-Jaramillo, Carlos MacQueen, Glenda Manchia, Mirko and Marsh, Wendy Martinez-Cengotitabengoa, Monica Melle, Ingrid and Monteith, Scott Morken, Gunnar Munoz, Rodrigo Nery, Fabiano G. O'Donovan, Claire Osher, Yamima Pfennig, Andrea and Quiroz, Danilo Ramesar, Raj Rasgon, Natalie Reif, Andreas and Ritter, Philipp Rybakowski, Janusz K. Sagduyu, Kemal and Scippa, Angela M. Severus, Emanuel Simhandl, Christian and Stein, Dan J. Strejilevich, Sergio Sulaiman, Ahmad Hatim and Suominen, Kirsi Tagata, Hiromi Tatebayashi, Yoshitaka and Torrent, Carla Vieta, Eduard Viswanath, Biju Wanchoo, Mihir J. Zetin, Mark Whybrow, Peter C.

Abstract

Background: The onset of bipolar disorder is influenced by the interaction of genetic and environmental factors. We previously found that a large increase in sunlight in springtime was associated with a lower age of onset. This study extends this analysis with more collection sites at diverse locations, and includes family history and polarity of first episode. Methods: Data from 4037 patients with bipolar I disorder were collected at 36 collection sites in 23 countries at latitudes spanning 3.2 north (N) to 63.4 N and 38.2 south (S) of the equator. The age of onset of the first episode, onset location, family history of mood disorders, and polarity of first episode were obtained retrospectively, from patient records and/or direct interview. Solar insolation data were obtained for the onset locations. Results: There was a large, significant inverse relationship between maximum monthly increase in solar insolation and age of onset, controlling for the country median age and the birth cohort. The effect was reduced by half if there was no family history. The maximum monthly increase in solar insolation occurred in springtime. The effect was one-third smaller for initial episodes of mania than depression. The largest maximum monthly increase in solar insolation occurred in northern latitudes such as Oslo, Norway, and warm and dry areas such as Los Angeles, California. Limitations: Recall bias for onset and family history data. Conclusions: A large springtime increase in sunlight may have an important influence on the onset of bipolar disorder, especially in those with a family history of mood disorders. (C) 2014 Elsevier B.V. All rights reserved.

Published
2014

61. Corrigendum to “Inhibition of inositol monophosphatase (IMPase) at the calbindin-D28k binding site: Molecular and behavioural aspects” [Eur. Neuropsychopharmacol. 23 (2013) 1806–1815]

Author

Levi, Itzhak, primary, Eskira, Yael, additional, Eisenstein, Miriam, additional, Gilon, Chaim, additional, Hoffman, Amnon, additional, Tal-Gan, Yftah, additional, Fanous, Joseph, additional, Bersudsky, Yuly, additional, Belmaker, RH, additional, Agam, Galila, additional, and Almog, Orna, additional

Published
2015
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64. Curcumin as an Add-On to Antidepressive Treatment

Author

Bergman, Joseph, primary, Miodownik, Chanoch, additional, Bersudsky, Yuly, additional, Sokolik, Shmuel, additional, Lerner, Paul P., additional, Kreinin, Anatoly, additional, Polakiewicz, Jacob, additional, and Lerner, Vladimir, additional

Published
2013
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66. Normobaric Hyperoxia Treatment of Schizophrenia

Author

Bloch, Yehudit, primary, Applebaum, Julia, additional, Osher, Yamima, additional, Amar, Shirly, additional, Azab, Abed N., additional, Agam, Galila, additional, Belmaker, R. H., additional, and Bersudsky, Yuly, additional

Published
2012
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78. IMPA1 is Essential for Embryonic Development and Lithium-Like Pilocarpine Sensitivity

Author

Cryns, Kim, primary, Shamir, Alon, additional, Van Acker, Nathalie, additional, Levi, Itzhak, additional, Daneels, Guy, additional, Goris, Ilse, additional, Bouwknecht, J Adriaan, additional, Andries, Luc, additional, Kass, Stefan, additional, Agam, Galila, additional, Belmaker, Haim, additional, Bersudsky, Yuly, additional, Steckler, Thomas, additional, and Moechars, Dieder, additional

Published
2007
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91. Inositol-Related Gene Knockouts Mimic Lithium's Effect on Mitochondrial Function.

Author

Toker, Lilach, Bersudsky, Yuly, Plaschkes, Inbar, Chalifa-Caspi, Vered, Berry, Gerard T, Buccafusca, Roberto, Moechars, Dieder, Belmaker, R H, and Agam, Galila

Subjects
*INOSITOL, *LITHIUM, *MITOCHONDRIA, *PHOSPHATIDYLINOSITOL 3-kinases, *LABORATORY mice
Abstract

The inositol-depletion hypothesis proposes that lithium attenuates phosphatidylinositol signaling. Knockout (KO) mice of two genes (IMPA1 or Slc5a3), each encoding for a protein related to inositol metabolism, were studied in comparison with lithium-treated mice. Since we previously demonstrated that these KO mice exhibit a lithium-like neurochemical and behavioral phenotype, here we searched for pathways that may mediate lithium's/the KO effects. We performed a DNA-microarray study searching for pathways affected both by chronic lithium treatment and by the KO of each of the genes. The data were analyzed using three different bioinformatics approaches. We found upregulation of mitochondria-related genes in frontal cortex of lithium-treated, IMPA1 and Slc5a3 KO mice. Three out of seven genes differentially expressed in all three models, Cox5a, Ndufs7, and Ndufab, all members of the mitochondrial electron transfer chain, have previously been associated with bipolar disorder and/or lithium treatment. Upregulation of the expression of these genes was verified by real-time PCR. To further support the link between mitochondrial function and lithium's effect on behavior, we determined the capacity of chronic low-dose rotenone, a mitochondrial respiratory chain complex I inhibitor, to alter lithium-induced behavior as measured by the forced-swim and the amphetamine-induced hyperlocomotion paradigms. Rontenone treatment counteracted lithium's effect on behavior, supporting the proposition suggested by the bioinformatics analysis for a mitochondrial function involvement in behavioral effects of lithium mediated by inositol metabolism alterations.The results provide support for the notion that mitochondrial dysfunction is linked to bipolar disorder and can be ameliorated by lithium. The phenotypic similarities between lithium-treated wild-type mice and the two KO models suggest that lithium may affect behavior by altering inositol metabolism. [ABSTRACT FROM AUTHOR]

Published
2014
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94. IMPA1 is Essential for Embryonic Development and Lithium-Like Pilocarpine Sensitivity.

Author

Cryns, Kim, Shamir, Alon, Van Acker, Nathalie, Levi, Itzhak, Daneels, Guy, Goris, Ilse, Bouwknecht, J. Adriaan, Andries, Luc, Kass, Stefan, Agam, Galila, Belmaker, Haim, Bersudsky, Yuly, Steckler, Thomas, and Moechars, Dieder

Subjects
BIPOLAR disorder, EMBRYOLOGY, LITHIUM, MICE, PHYSIOLOGICAL control systems, GENOTYPE-environment interaction
Abstract

Lithium has been the standard pharmacological treatment for bipolar disorder over the last 50 years; however, the molecular targets through which lithium exerts its therapeutic effects are still not defined. We characterized the phenotype of mice with a dysfunctional IMPA1 gene (IMPA1−/−) to study the in vivo physiological functions of IMPA1, in general, and more specifically its potential role as a molecular target in mediating lithium-dependent physiological effects. Homozygote IMPA1−/− mice died in utero between days 9.5 and 10.5 post coitum (p.c.) demonstrating the importance of IMPA1 in early embryonic development. Intriguingly, the embryonic lethality could be reversed by myo-inositol supplementation via the pregnant mothers. In brains of adult IMPA1−/− mice, IMPase activity levels were found to be reduced (up to 65% in hippocampus); however, inositol levels were not found to be altered. Behavioral analysis of the IMPA1−/− mice indicated an increased motor activity in both the open-field test and the forced-swim test as well as a strongly increased sensitivity to pilocarpine-induced seizures, the latter supporting the idea that IMPA1 represents a physiologically relevant target for lithium. In conclusion the IMPA1−/− mouse represents a novel model to study inositol homeostasis, and indicates that genetic inactivation of IMPA1 can mimic some actions of lithium.Neuropsychopharmacology (2008) 33, 674–684; doi:10.1038/sj.npp.1301431; published online 25 April 2007 [ABSTRACT FROM AUTHOR]

Published
2008
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95. Electroconvulsive therapy in the elderly.

Author

Dwodlatzky, Tzvi and Bersudsky, Yuly

Subjects
ELECTROCONVULSIVE therapy, ELECTROTHERAPEUTICS, SHOCK therapy, PSYCHOTHERAPY, MENTAL illness treatment
Abstract

Electroconvulsive therapy (ECT) involves the induction of a generalized tonic-clonic seizure by means of an electric current applied to the head of the patient. The procedure is performed under general anesthesia with the use of muscle relaxants. The efficacy and safety of ECT has been controversial since the introduction of this treatment in the 1930s. Today, ECT is considered to be a safe and effective therapeutic option in treating a number of psychiatric illnesses. With recent technical advances, ECT has fewer adverse results, is safer even in the very old and is effective for a wider range of indications. Nevertheless, many physicians remain hesitant to refer their patients for ECT because of the mistaken belief that this form of treatment is primitive and barbaric. In this article, we review the use of ECT in the elderly. [ABSTRACT FROM AUTHOR]

Published
2008
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98. HOW DOES LITHIUM WORK ON MANIC DEPRESSION? Clinical and Psychological Correlates of the Inositol Theory.

Author

Belmaker, R. H., Bersudsky, Yuly, Agam, Galila, Levine, Joseph, and Kofman, Ora

Subjects
*THERAPEUTIC use of lithium, *INOSITOL phosphates
Abstract

Discusses the clinical significance of lithium. Biological effects of lithium; Impact of lithium on inositol monophosphatase; Problems associated with lithium treatment in humans; Difficulties with the inositol theory of lithium action.

Published
1996
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100. Bayesian approach to bipolar guidelines.

Author

Belmaker, R.H., Bersudsky, Yuly, and Lichtenberg, Pesach

Subjects
*LETTERS to the editor, *BIPOLAR disorder
Abstract

A letter to the editor is presented in response to an article about the World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders.

Published
2010
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