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Workplace stress or professional stress is a specific type of stress that is highly prevalent among police officers. Police officers are exposed to high levels of stress and its negative impact ontheir physical and mental health, as well as their social lives. The aim of this research is to determine the attitudes regarding the connection between physical fitness and stress prevention among police officers. The sample consists of 516 employees from police departments in the Central Bosnia Canton. The sample is structured with 312 male participants and 204 female participants. Both descriptive and analytical methods were applied in this research, as the descriptive method was used to describe the distribution of the studied phenomenon, while the analytical part followed the logic of the research. Analyzing all the results, it can be concluded that there is a high level of satisfaction with the management of work processes among police officers and with stress reduction in the workplace. The conclusion arises about the necessity of increasing the number of hours of police training, primarily for basic and investigative police work, in stress prevention among police officers. The results of comparative analysis indicate that there is no statistically significant difference among participants based on gender. The results show that the age of the participants significantly influences their attitudes towards overall satisfaction with management quality. Theresults suggest that participants who have been employed the longest and make the most use of the existing infrastructure express more positive attitudes

The study of hydrogen peroxide reduction in an alkaline aqueous medium on a composite of palladium particles dispersed in an amorphous carbon matrix (Pd@AC) was performed. Scanning Electron Microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FTIR), and X-ray Powder Diffraction (XRD) were used to examine morphology, composition, and crystalline structure. The crystalline structure and size of palladium were analyzed using XRD. The reduction of hydrogen peroxide was studied through cyclic and square-wave voltammetry in an alkaline solution in the absence and presence of dissolved oxygen. The overall electrocatalytic effect of Pd@AC toward hydrogen peroxide reduction strongly depends on the presence of oxygen and the hydrogen peroxide disproportionation reaction in the three-phase system of amorphous carbon, palladium particles, and electrolyte solution.

Textile dyes discharged into aquatic systems can have significant environmental impacts, causing water pollution and toxicity to aquatic life, and constituting a human health risk. To manage these effects, the sorption ability of wood biowaste chemically modified by Bi2O3 for textile dye removal was investigated. Sorbent characterization was performed using scanning electron microscopy, and elemental analysis by energy dispersive X-ray spectroscopy (SEM-EDX), X-ray diffraction (XRD), the Brunauer–Emmett–Teller (BET) method for the specific surface area, and Fourier transform infrared spectroscopy–attenuated total reflectance (FTIR-ATR). The optimization of the sorption process was carried out, and optimal parameters, such as contact time, pH, the dose of sorbent, the concentration of dye, and temperature, were defined. Also, desorption studies were conducted. Kinetics and isotherms studies were carried out, and the data fits to a pseudo-second order model (r2 ≥ 0.99) and Langmuir model (r2 ≥ 0.99), indicating that the process occurs in the monolayer form and the dye sorption depends on the active sites of the sorbent surface. The maximal sorption capacity of the sorbent was 434.75 mg/g. [ABSTRACT FROM AUTHOR]

Spondyloepiphysal dysplasia congenita (SEDc) is a rare autosomal dominant genetic disorder. Femoral head ossification delay and the proximal femur varus deformity i.e. coxa vara (CV) are the major features of SEDc. The accepted treatment is a valgus femoral osteotomy. The data on hip surgery in SEDc are scarce. In our database from 2006 to 2020, there were 6 SEDc patients. Four patients had surgery on 8 hips. Surgical treatment was indicated due to progressive CV deformity i.e. a decreasing neck-shaft angle (NSA), pain, limited hip abduction, and gait disturbances. In three patients, a novel surgical treatment was applied – a greater trochanter apo-physiodesis using “Eight-plate”. The patients were evaluated clinically and radiologically. The median age at first surgery was 6.3 years (range, 3.2 to 9.5 y) and the median follow-up period was 7 years (range, 5.6 to 14 y). The postoperative NSA was significantly improved with a mean increase of 13 degrees (P

Aim. The retrospective observational study aimed to determine whether there is a defined syndrome after intensive care after less than 14 days of stay in the intensive care unit. Material and methods. Patients who stayed in the intensive care unit of the Clinical Hospital Center “Dr. Dragiša Mišović – Dedinje” in Belgrade during the May 2022 were examined. Data from the health information system and therapeutic lists were used, and the questionnaire on quality of life was filled out during telephone conversations with patients. In the end, the data were statistically processed. Results. Of 16 patients, the average stay in the intensive care unit was 4.7 days (from 2 to 10). In eight of them, a certain level of change in the general state of health was shown in the last year (which includes the period of hospitalization), and in two of them this change was significant. The general health was significantly impaired in four of them, primarily related to male sex, age and ASA status. In these four patients, the length of stay in the intensive care unit was eight days at maximum. Conclusion. The results of this pilot study indicate the occurrence of the syndrome after intensive treatment in our sample of patients. As the sample is small, more extensive studies are needed to confirm or refute the claim that even a stay shorter than 14 days in intensive care units can lead to a significant change in health status and the emergence of post-intensive care syndrome in critically ill patients.

This study aims to describe the clinical characteristics, radiological and laboratory results, therapy and outcome of pregnancies complicated by COVID-19 infection. Methodology. A retrospective descriptive study included all pregnant women with COVID-19 who gave birth in our hospital from April 2020 to January 2022. Exclusion criteria were: incomplete or unclear medical documentation, suspected COVID-19 infection without confirmation by PCR or rapid Ag test, previously diagnosed autoimmune diseases, positive history of malignant diseases, and started oxygen support in another institution before admission to our hospital. Results. Our study included 186 pregnant women who gave birth at KBC “Dr. Dragiša Mišović – Dedinje” in the mentioned period. Of these, 69 had no symptoms of COVID-19 infection, and 67 developed a milder clinical picture. In comparison, 41 pregnant women were diagnosed with bilateral pneumonia. A total of 38 pregnant women were admitted to the intensive care unit, of which 32 pregnant women needed oxygen support, 20 pregnant women were on an oxygen mask, 2 of them on a high-flow nasal canal, four pregnant women on non-invasive mechanical ventilation and six pregnant women on invasive mechanical ventilation. Of the total number of patients, 111 had a natural vaginal delivery, while 75 underwent cesarean section. Of 111 pregnant women who had a vaginal delivery, 92 (83%) received epidural analgesia, while 19 (17%) did not. Among pregnant women undergoing cesarean section, nine pregnant women (12%) received epidural anesthesia, 51 of them (68) received spinal anesthesia, while a cesarean section in 15 pregnant women (20%) was performed under general balanced anesthesia. Of 186 hospitalized and delivered pregnant women, 183 (98.4%) were discharged home in good general condition, while three (1.6%) had a fatal outcome. Conclusion. The clinical manifestations of pregnant women suffering from COVID-19 infection corresponded to the symptoms of the general population to the greatest extent. In contrast, the excessive use of antibiotics, even for asymptomatic patients, is very worrying.

Introduction Acute postoperative pain can lead to various complications, affecting cardiovascular, respiratory , gastrointestinal, and renal systems, increases the costs of treatment and affects patient satisfaction. The pain prediction contributes to optimization of acute pain treatment with pain threshold and tolerance serving as key predictors of pain. Pain threshold measures the intensity of a stimulus causing pain, while pain tolerance is the maximum pain a person can endure. Objective/Aim This review aims to investigate whether pain threshold and pain tolerance can predict the intensity of acute postoperative pain. Methods We assessed published data on pain threshold, tolerance and acute postoperative pain from the past 10 years. Five relevant studies were included after screening 26 papers. Various study types were considered, including systematic reviews, prospective observational and randomized control studies. Results Patients with higher preoperative pain tolerance reported higher pain scores postoperatively. Another investigation found that patients with a higher threshold for pressure pain before surgery experienced less pain after surgery. Preoperative pain tolerance strongly predicts intensity of acute postoperative pain. Pain threshold derived from EEG has predictive accuracy for acute postoperative pain. Research on postoperative pain demonstrated that transcutaneous electrical nerve stimulation increased pain thresholds. A systematic review concluded that lower preoperative heat pain thresholds were associated with higher postoperative pain after various surgeries. Conclusion Pain threshold and pain tolerance could serve as good predic-tors of acute postoperative pain. While these tests show promise, challenges include time consumption and resource demands. Further research is needed to develop cost-effective and time-efficient tests for timely identification of patients at risk for acute postoperative pain.

The present paper focuses on teacher’s role in social justice and explores how teachers perceive and react upon diversity and inequality in their classrooms. Through a literature review, we aimed to answer three research questions: 1) what are diversity awareness and critical consciousness in education; 2) why are diversity awareness and critical consciousness important; and 3) how can diversity awareness and critical consciousness be supported in teachers. The literature review has revealed that most papers on teachers’ diversity awareness and critical consciousness have been published within the last few years and that the importance of the two concepts has been recognized for a wide range of educators. There seems to be a growing interest in this topic due to the increase of the diversity in classrooms and the recognition of the teachers’ role in addressing diversity and inequality. However, large-scale studies would be a needed contribution to the field, as most of the existing studies are small-scale. Based on this review, we argue that both diversity awareness and critical consciousness need to be supported through preservice and in-service teacher professional development programs, if we are to make education systems more inclusive for all.

Background/Aim: Clinical research nursing is a well-known concept in Europe and other countries. The purpose of this study was to investigate the nurses' knowledge and attitudes towards clinical research and their opinions and self-evaluation about clinical research nursing and factors affecting them. Methods: A cross sectional study was conducted at the University Clinical Centre of the Republic of Srpska (UCCRS). A questionnaire included 50 questions/ statements was created in order to address the aims of the research and afterwards distributed to 120 nurses from 6 departments. Results: Response rate was 91.6 %. Most of the respondents showed a low level of knowledge, but positive attitude related to clinical research. Nurses who participated in clinical research were confident in their competencies according to their self-evaluation. Conclusion: Systematic approach to the additional nurses education could have a significant impact on a success of clinical research.

In recent years, online dating websites, applications, and social media have become increasingly popular tools for finding romantic and/or sexual partners. Individual differences in personality traits predict the use of online dating websites and applications and also influence the motives for their use. Previous work regarding mating strategies in the context of online dating has focused on the Dark Tetrad concept of malevolent personality while ignoring the Light Triad concept of beneficent personality. Light and dark personality traits are not seen as polar opposites as they supplement each other. Thus, the current study aimed to explore the utility of both light (i.e., Faith in Humanity, Humanism, and Kantianism) and dark (i.e., Machiavellianism, narcissism, psychopathy, and sadism) personality traits in predicting mating strategies in the online context. A total of 216 participants, ages 20 to 56, which used online dating sites, apps, and social media for finding partners in the past year, completed an online questionnaire assessing Dark Tetrad traits, Light Triad traits, and mating orientations. Narcissism, psychopathy, and sadism positively correlated, while Faith in Humanity and Kantianism negatively correlated with short-term mating. However, only Faith in Humanity was a significant predictor of short-term mating. As for long-term mating, the results have shown that it is negatively related to psychopathy and sadism, while it is positively related to all Light Triad traits. Faith in Humanity, Humanism, and Kantianism were significant predictors of long-term mating. These findings highlight the utility of the Dark Tetrad and Light Triad traits in mating orientation research.

A quantitative analysis was conducted on the tweets of 20 leading Serbian mass media outlets and their followers during the three months from January 1 to March 30, 2021. The analysis, that encompassed more than 1 million tweets, was conducted using (a) Twitter API, (b) the Serbian version of LIWC linguistic dictionary, and (c) additional statistical analyses. Analyses revealed that words related to affective processes (negative emotions), social processes (family and friends), perceptual processes (feel and hear), and personal concerns (work and religion) expressed in tweets of mass media were predictors of the same words in not necessarily related tweets of their followers. The research has shown that spread of psychological and linguistic patterns by media and social networking sites is not limited to negative emotions solely. This research highlights the significance of recommender systems, as they help to determine the content that social media users encounter on a personal level. The findings also indicate how we can address emerging and pressing issues that affect individuals' well-being and democratic capacity, such as echo chambers and polarization. The obtained findings are in line with the communication accommodation theory, emotional contagion theory and negativity bias. Limitations of the present research, future directions, and implications are discussed.

Assessment of the functional significance of coronary artery stenosis using invasive measurement of fractional flow reserve (FFR) or non-hyperemic indices has been shown to be safe and effective in making clinical decisions on whether to perform percutaneous coronary intervention (PCI). Despite strong evidence from clinical trials, utilization of these techniques is still relatively low worldwide. This may be to some extent attributed to factors that are inherent to invasive measurements like prolongation of the procedure, side effects of drugs that induce hyperemia, additional steps that the operator should perform, the possibility to damage the vessel with the wire, and additional costs. During the last few years, there was a growing interest in the non-invasive assessment of coronary artery lesions, which may provide interventionalist with important physiological information regarding lesion severity and overcome some of the limitations. Several dedicated software solutions are available on the market that could provide an estimation of FFR using 3D reconstruction of the interrogated vessel derived from two separated angiographic projections taken during diagnostic coronary angiography. Furthermore, some of them use data about aortic pressure and frame count to more accurately calculate pressure drop (and FFR). The ideal non-invasive system should be integrated into the workflow of the cath lab and performed online (during the diagnostic procedure), thereby not prolonging procedural time significantly, and giving the operator additional information like vessel size, lesion length, and possible post-PCI FFR value. Following the development of these technologies, they were all evaluated in clinical trials where good correlation and agreement with invasive FFR (considered the gold standard) were demonstrated. Currently, only one trial (FAVOR III China) with clinical outcomes was completed and demonstrated that QFR-guided PCI may provide better results at 1-year follow-up as compared to the angiography-guided approach. We are awaiting the results of a few other trials with clinical outcomes that test the performance of these indices in guiding PCI against either FFR or angiography-based approach, in various clinical settings. Herein we will present an overview of the currently available data, a critical review of the major clinical trials, and further directions of development for the five most widely available non-invasive indices: QFR, vFFR, FFRangio, caFFR, and AccuFFRangio.

Intensive shipping activity in port areas is considered one of the leading problems in the maritime sector, which has a negative effect on climate change and local air quality. The compilation of detailed inventories of combustion gases released by ships should therefore provide a more accurate overview of emission levels, which can serve as a basis for analysing impacts on the port community and lead to the establishment of better environmental measures. Thus, the aim of this study was to develop an adaptable and relevant analytical model capable of integrating a comprehensive methodology with large databases of ship movements and technical details to provide clear ship-related emission estimates in large port areas. Considering the lack of research in Croatia that includes the mentioned approach and the insufficient monitoring of air pollutants in ports, the model was used to produce an initial overall emissions inventory for the Port of Split, the busiest passenger port in Croatia. In the model, bottom-up logic with an energy-based method was applied to detailed technical and near-real-time shipping data from AIS, creating the first high-density spatial and temporal overview of shipping emissions in the City port basin. The results showed strong seasonal fluctuations and large discrepancies in the quantities emitted between different ship types and operating modes. The analysis therefore raised the question of the need for the future development and implementation of a scalable system that would provide a more transparent and efficient overview of the important characteristics of air pollution from ships and port areas.

Successful pregnancy establishment requires highly synchronized cross talk between the invasive trophoblast cells and the receptive maternal endometrium. Any disturbances in this tightly regulated process may lead to pregnancy complications. Local factors such as nutrients, hormones, cytokines and reactive oxygen species modulate the invasion of extravillous trophoblasts through critical signaling cascades. Epidemiological studies strongly indicate that a Mediterranean diet can significantly impact molecular pathways during placentation. Therefore, the aim of the current study was to examine whether oleuropein (OLE), one of the main compounds of the Mediterranean diet, may influence trophoblast cell adhesion and migration, as well as the expression of invasion-associated molecular markers and inflammatory pathways fostering these processes. HTR-8/SVneo cells were incubated with OLE at selected concentrations of 10 and 100 µM for 24 h. Results showed that OLE did not affect trophoblast cell viability, proliferation and adhesion after 24 h in in vitro treatment. The mRNA expression of integrin subunits α1, α5 and β1, as well as matrix-degrading enzymes MMP-2 and -9, was significantly increased after treatment with 10 µM OLE. Furthermore, OLE at a concentration of 10 µM significantly increased the protein expression of integrin subunits α1 and β1. Also, OLE inhibited the activation of JNK and reduced the protein expression of COX-2. Finally, a lower concentration of OLE 10 µM significantly stimulated migration of HTR-8/SVneo cells. In conclusion, the obtained results demonstrate the effects of OLE on the function of trophoblast cells by promoting cell migration and stimulating the expression of invasion markers. As suggested from results, these effects may be mediated via inhibition of the JNK signaling pathway.

Patients suffering from cholelithiasis have an increased risk of developing cardiovascular complications, particularly ischemic myocardial disease. Ursodeoxycholic acid (UDCA), already used in clinical practice for the treatment of cholelithiasis and related conditions, has proven antioxidative, anti-inflammatory, and cytoprotective effects. Therefore, the aim of this study was to investigate the cardioprotective effect of UDCA pre-treatment on isoprenaline-induced myocardial injury in rats. Male Wistar albino rats were randomized into four groups. Animals were pre-treated for 10 days with propylene glycol + saline on days 9 and 10 (control), 10 days with propylene glycol + isoprenaline on days 9 and 10 (I group), 10 days with UDCA + saline on days 9 and 10 (UDCA group), and 10 days with UDCA + isoprenaline on days 9 and 10 (UDCA + I group). UDCA pre-treatment significantly reduced values of high-sensitivity troponin I (hsTnI) and aspartate aminotransferase (AST) cardiac markers (p < 0.001 and p < 0.01, respectively). The value of thiobarbituric acid reactive substances (TBARS) was also decreased in the UDCA + I group compared to the I group (p < 0.001). UDCA also significantly increased glutathione (GSH) levels, while showing a tendency to increase levels of superoxide dismutase (SOD) and catalase (CAT). The level of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) expression, a key regulatory gene of inflammation, was diminished when UDCA was administered. A reduction of cardiac damage was also observed in the UDCA pre-treated group. In conclusion, UDCA pre-treatment showed a cardioprotective effect on isoprenaline-induced myocardial injury in rats, primarily by reducing oxidative stress and inflammation. [ABSTRACT FROM AUTHOR]

Background and Objectives: Left ventricular aneurysm (LVA) is associated with a decline in cardiac function, evidenced by a lower ejection fraction (EF), due to the reduction in the proportion of functional myocardium. The left ventricular end-diastolic volume (LVEDV), the left ventricular aneurysm volume (LVAV), and the LVAV/LVEDV ratio show a strong correlation with the EF. The aim of this study was to determine LVA characteristics post-myocardial infarction (basal vs. apical) and to evaluate the impact of aneurysm volume in diastole (LVAVd), aneurysm area in diastole (LVAAd), and their respective ratios with LVEDV and area (LVEDA) on the EF, in order to identify the most critical predictive factors for assessing and managing the negative impact of aneurysms on cardiac function. Materials and Methods: This observational study included post-infarction LVA patients at the "Dedinje" Cardiovascular Institute in Belgrade, Serbia, undergoing routine transthoracic echocardiography. Echocardiography assessed volumes (LVEDV, LVESV, LVAVd, LVAVs) and areas (LVAAd, LVAAs, LVEDA, LVESA) using the area–length method. The ratios (LVAVd/LVEDV, LVAVs/LVESV, LVAAd/LVEDA, LVAAs/LVESA) were derived from these measures. The left ventricular EF was calculated using Simpson's method. Results: Basal aneurysms showed a significantly smaller LVAVd (p = 0.016), LVAAd (p = 0.003), and LVAAs (p = 0.029) compared to apical aneurysms, indicating that basal aneurysms are smaller in size. However, there was no significant difference in the EF and overall LV volumes between the groups, although the basal aneurysm group had a slightly higher EF and end-diastolic volume, with a slightly lower end-systolic volume. Furthermore, when comparing the correlation between the EF and the LVAVd, the LVEDV, and the LVAVd/LVEDV ratio, the results indicate that the LVAVd had the greatest impact on the EF (−0.695), followed by the LVAVd/LVEDV ratio (−0.637), and the lowest correlation is between the EF and LVEDV. A similar relationship is observed when comparing the EF with the LVESV, the LVAVs, and the LVAVs/LVESV ratio. Conclusions: Basal aneurysms are significantly smaller than apical ones, yet EF and LV volumes remain similar between the groups, with the EF being slightly higher in the basal group. In cases of LVA, LVAVd shows the strongest negative correlation with the EF, indicating its significant impact on systolic function, followed by the LVAVd/LVEDV ratio, with the weakest correlation seen between the EF and LVEDV. [ABSTRACT FROM AUTHOR]

Galectins are a class of lectins that are extensively expressed in all organisms. Galectins are involved in a range of functions, including early development, tissue regeneration, cancer and inflammation. It has been shown that galectin-8 is expressed in the villous and extravillous trophoblast (EVT) cells of the human placenta; however, its physiological role in pregnancy establishment has not been elucidated. Taking these factors into account, we investigated the functional role of galectin-8 in HTR-8/SVneo cells—a human EVT cell line—and human primary cytotrophoblast cells isolated from a first-trimester placenta. We analyzed the effects of recombinant human galectin-8 (rh galectin-8) on the adhesion, migration and invasion of HTR-8/SVneo cells. We used qPCR, cell-based ELISA (cELISA) and gelatin zymography to study the effects of galectin-8 on mediators of these processes, such as integrin subunits alpha-1 and beta-1 and matrix metalloproteinases (MMPs)-2 and -9, on the mRNA and protein levels. Further, we studied the effects of galectin-8 on primary cytotrophoblast cells' invasion. Galectin-8 stimulated the adhesion, migration and invasion of HTR-8/SVneo cells, as well as the invasion of primary cytotrophoblasts. In addition, the MMP-2 and -9 levels were increased, while the expression of integrins alpha-1 and beta-1 was not affected. Galectin-8 has the ability to positively affect EVTs' invasion, so it can be considered a significant factor in the trophoblast cell invasion process. [ABSTRACT FROM AUTHOR]

Acute mesenteric ischaemia (AMI) is a serious disease with mortality between 50 and 80 %. Oxidative stress plays a major role in the pathophysiology of AMI. AMI should be considered for any acute abdominal pain that requires analgesia with morphine and for which no other obvious aetiology is found. CT is the main diagnostic procedure to confirm the diagnosis of AMI. There is no specific diagnostic biomarker for AMI that can be used in routine practice. AMI is an urgent diagnostic and therapeutic situation. Treatment of AMI includes a protocol combining digestive rest, curative anticoagulant, antiplatelet, antibiotic therapy, arterial revascularisation to salvage viable bowel and resection of necrotic digestive segments. The strategy of revascularisation depends on the mechanism of arterial occlusion, the morphological appearance of the lesions and the indications for exploratory laparotomy. Endovascular and open surgical techniques can be combined and complemented. Open surgical revascularisation is indicated in case of failure or impossibility of endovascular revascularisation and in case of need for laparotomy. Early diagnosis and timely surgical intervention are the cornerstones of modern treatment to reduce the high mortality of AMI. The emergence of endovascular approaches and modern imaging techniques is developing and providing new treatment options. A multidisciplinary approach based on early diagnosis and treatment is necessary. [ABSTRACT FROM AUTHOR]

Background and Objectives: The saphenous vein graft (SVG) remains the most frequently used conduit worldwide, despite its common disadvantage of early graft failure. To solve the problem and reduce the SVG damage, Souza implemented a new technique where a vein is harvested with surrounding fascia and fat tissue (the so-called no-touch technique). Materials and Methods. A prospective study conducted from February 2019 to June 2024 included 23 patients who underwent myocardial revascularization using a no-touch vein, with follow-up control examinations using computed tomographic angiography to detect graft stenosis or occlusion. Results. Of the entire patient group, 17 (73.9%) were male, with a mean age of 67.39 ± 7.71 years. The mean follow-up period was 25 months. There were no major adverse cardiovascular or cerebrovascular events (MACCEs) during hospitalization, although one patient died in the hospital. Another patient died due to malignancy, but no MACCEs occurred during the follow-up period. According to multi-slice CT coronary angiography, the results were impeccable, with an astonishing 100% patency observed in all 20 IMA grafts and 58 no-touch SVGs examined. Conclusions. The excellent patency rate during the early follow-up period confirmed that the no-touch technique is a good option for surgical revascularization. [ABSTRACT FROM AUTHOR]

Antiphospholipid syndrome (APS) is a complex thrombo-inflammatory autoimmune disease characterized by the presence of antiphospholipid antibodies (aPL). Women with APS are at high risk of recurrent early pregnancy loss as well as late obstetrical complications—premature birth due to placental insufficiency or severe preeclampsia. Accumulating evidence implies that vascular thrombosis is not the only pathogenic mechanism in obstetric APS, and that the direct negative effect of aPL on the placental cells, trophoblast, plays a major role. In this review, we summarize the current findings regarding the potential mechanisms involved in aPL-induced trophoblast dysfunction. Introduction on the APS and aPL is followed by an overview of the effects of aPL on trophoblast—survival, cell function and aPL internalization. Finally, the implication of several non-coding RNAs in pathogenesis of obstetric APS is discussed, with special emphasis of their possible role in trophoblast dysfunction and the associated mechanisms.

In the era of digitalization, boosted by Covid-19 pandemic, there is a constant need to measure the success of digital education, compare and reappraise its positive and negative outcomes, which are mainly dependent on the technical conditions available, as well as on the extent to which the previous knowledge of teachers has been adapted to practical and technical challenges. The aim of this paper is to present an analysis of the advantages and disadvantages of digitized education as perceived by students in a qualitative survey, conducted in 2021/22. The starting point were two hypotheses related to positive aspects and two hypotheses related to negative aspects of online learning. An in-depth interview was conducted among 20 high school and 20 university students. By analyzing the results obtained, and juxtaposing them with the data taken from a quantitative survey administered prior to the qualitative one, in 2020/21, it is possible to compare the changes that took place and gain a better insight into the entire process, which has undergone certain improvements, but which also leaves room for further enhancement, particularly in terms of students' and teachers' motivation to actively engage and interact. This would help students overcome their distrust of online education.

Out of many civil law topics that Mihailo Konstantinović dealt with, the author analyzes the institute of ownership, i.e., the issue of legal guarantees of ownership. Namely, Konstantinović wrote about the notion of the ownership, pointing out that in different times ownership was defined differently and that property owners throughout history did not always have the same scope of authority. In this way, Konstantinović opened the issue of the limitation of ownership and problematized the idea of its inviolability. This paper, inspired by Konstantinović's lines on the "ownership issue", analyzes the concept of legal guarantees of ownership. The paper also offers criteria for distinguishing the term ownership limitation from related terms, considering that precise terminology is the basis of the system that forms the backbone of property law. Thus, the key part of property law could be systematized through three units: ownership, limitations, and deprivation of ownership.

Both tech companies and AI algorithms exercise immense power in today's globally interconnected world, which is based on big data and digital footprints of online users. This paper analyses the transfer of power from societies to tech companies and algorithms with the aim of examining whether recommender algorithms can be considered a public good. Deployed methods include content analysis and literature reviews. The study has found that control exercised over public opinion, decisions and moods of online users is unprecedented to such a high degree in human history. The above-mentioned control is based on the impact of both tech companies and algorithms. The limitation of this research is the lack of quantitative analysis. Future research should concentrate on defining recommender algorithms as a public good and analyzing how different media content, including virtual reality, affects citizens' psychology.

The aim of this paper is to clarify specific aspects of the impact of the brain-machine interface on our understanding of subjectivity. The brain-machine interface is presented as a phase of cyborgization of humans. Some projects in the field of brain-machine interface are aimed at enabling consensual telepathy - communication without symbolic mediation. Consensual telepathy refers to one of potential ways of transmission of information within singularity. Therefore, consensual telepathy is an important aspect of singularity. Singularity or human-machine symbiosis shows some similarities with child-mother unity. Therefore, the psychodynamic perspective might be considered useful in thinking about human-machine symbiosis. Knowledge from developmental psychodynamic psychology combined with insights by Slavoj Žižek and Jean Baudrillard provides an additional perspective looking at human-machine symbiosis. The paper claims that if consensual telepathy becomes another way of communication, it will have the potential to annihilate subjectivity making it schizophrenic. At the same time, we look at the possibility of an escape from our inner world through the prism of addictions.

U ovom radu donosimo kratak prikaz posljednje reforme portugalskoga pravopisa formulirane 1990. i obvezujuće od 2015. u Portugalu i 2016. godine u Brazilu, a čiji je cilj bio jednim normativnim dokumentom ujediniti dosadašnja dva pravopisa, od kojih je jedan vrijedio za Brazil, a drugi za Portugal i ostale luzofone zemlje. Novi pravopisni sporazum pritom samo djelomično unificira dosadašnja dva pravopisa jer taj novi službeni pravopis dopušta varijantnost u određenom broju slučajeva koja odražava neke razlike u izgovoru pojedinih glasova. Osim pregleda glavnih pravopisnih inovacija, osvrćemo se na najistaknutije prosudbe o pravopisnoj reformi zabilježene u medijima i stručnim tekstovima tijekom javne rasprave koja traje i danas.

One way of testing a malware detection tool is to expose it to a large number of diverse malware samples and verify its detection accuracy. During these tests, the host system must not be harmed by malware and yet be able to analyze its harmful behavior. An additional challenge is to run a large number of executables in the shortest amount of time. Advanced malware can even stop its execution when detecting a simulation. This paper presents a framework for automated malware analysis on Linux. The proposed solution addresses these problems with parallel realistic simulations. Existing malware analysis methods are discussed, as well as technical details behind reliable execution simulations.