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60 results on '"Bonaiuto, Emanuela"'

53. Magnetic Purification of Curcumin from Curcuma longa Rhizome by Novel Naked Maghemite Nanoparticles

Author

Magro, Massimiliano, primary, Campos, Rene, additional, Baratella, Davide, additional, Ferreira, Maria Izabela, additional, Bonaiuto, Emanuela, additional, Corraducci, Vittorino, additional, Uliana, Maíra Rodrigues, additional, Lima, Giuseppina Pace Pereira, additional, Santagata, Silvia, additional, Sambo, Paolo, additional, and Vianello, Fabio, additional

Published
2015
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55. Colloidal Surface Active Maghemite Nanoparticles for Biologically Safe CrVI Remediation: from Core-Shell Nanostructures to Pilot Plant Development.

Author

Magro, Massimiliano, Domeneghetti, Stefania, Baratella, Davide, Jakubec, Petr, Salviulo, Gabriella, Bonaiuto, Emanuela, Venier, Paola, Malina, Ondřej, Tuček, Jiří, Ranc, Václav, Zoppellaro, Giorgio, Zbořil, Radek, and Vianello, Fabio

Subjects
TOXICOLOGY of chromium, MAGHEMITE, SURFACE active agents, SALMONELLA typhimurium, CHROMIUM in water, OXYANIONS, THERAPEUTICS
Abstract

The present study is aimed at the exploration of achievable improvements for CrVI ex situ and in situ water remediation by using novel naked colloidal maghemite (γ-Fe2O3) nanoparticles (surface active maghemite nanoparticles, SAMNs). The reliability of SAMNs for CrVI binding and removal was demonstrated, and SAMN@CrVI complex was characterized, as well as the covalent nature of the absorption was unequivocally proved. SAMNs were structurally and magnetically well conserved after CrVI binding. Thus, in consideration of their affinity for CrVI, SAMNs were exploited in a biological model system, mimicking a real in situ application. The assay evidenced a progressive reduction of revertant colonies of Salmonella typhimurium TA100 strain, as maghemite nanoparticles concentration increased, till the complete suppression of CrVI mutagen effect. Finally, an automatic modular pilot system for continuous magnetic removal and recovery of CrVI from water is proposed. SAMNs, thanks to their colloidal, binding, and catalytic properties, represent a promising tool as a reliable nanomaterial for water remediation by CrVI. [ABSTRACT FROM AUTHOR]

Published
2016
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56. Ternary Hybrid γ-Fe2O3/CrVI/Amine Oxidase Nanostructure for Electrochemical Sensing: Application for Polyamine Detection in Tumor Tissue.

Author

Bonaiuto, Emanuela, Magro, Massimiliano, Baratella, Davide, Jakubec, Petr, Sconcerle, Elisabetta, Terzo, Milo, Miotto, Giovanni, Macone, Alberto, Agostinelli, Enzo, Fasolato, Silvano, Venerando, Rina, Salviulo, Gabriella, Malina, Ondrej, Zboril, Radek, and Vianello, Fabio

Subjects
*AMINE oxidase, *NANOSTRUCTURES, *BIOMACROMOLECULES, *MAGHEMITE, *HYDROGEN peroxide, *ELECTROCHEMICAL sensors
Abstract

Dichromate binds to surface-active maghemite nanoparticles (SAMNs) to form a stable core-shell nanostructures (SAMN@CrVI). The hybrid was characterized by Mössbauer spectroscopy, high-angle annular dark-field imaging, electron energy-loss spectroscopy, and electrochemical techniques, which revealed a strong interaction of dichromate with the nanoparticle surface. Electrochemical characterization showed lower charge-transfer resistance, better electrochemical performance, and more reversible electrochemical behavior with respect to naked SAMNs. Moreover, SAMN@CrVI is an excellent electrocatalyst for hydrogen peroxide reduction. Furthermore, an enzyme, namely, bovine serum amine oxidase (BSAO: EC 1.4.3.6), was immobilized on SAMN@CrVI by self-assembly to give a ternary hybrid nanostructured catalyst for polyamine oxidation (SAMN@CrVI-BSAO). SAMN@CrVI-BSAO was applied for the development of a reagentless, fast, inexpensive, and interference-free polyamine biosensor, which was successfully exploited for the discrimination of tumorous tissue from healthy tissue in human crude liver extracts. [ABSTRACT FROM AUTHOR]

Published
2016
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57. Protein corona for proteome fingerprinting

Author

Fabio Vianello, Magro, Massimiliano, Davide Baratella, Bonaiuto, Emanuela, GIORGIO COZZA, Giovanni Miotto, and Zboril, Radek

Subjects
protein corona, Magnetic nanoparticles, biomarker, Magnetic nanoparticles, protein corona, biomarker, mass spectrometry, mass spectrometry

58. Iron oxide-chromate core-shell nanostructure for the electrochemical biosensing of polyamines in liver cancer tissues

Author

Magro, Massimiliano, Bonaiuto, Emanuela, Davide Baratella, Jakubec, Petr, Sconcerle, Elisabetta, Terzo, Milo, Giovanni Miotto, Macone, Alberto, Agostinelli, Enzo, Fasolato, Silvano, Tucek, Jiří, Zboril, Radek, and Fabio Vianello

Subjects
hybrid nanomaterial, Maghemite, polyamine biosensor, chromium, hepatocellular carcinoma, Maghemite, hybrid nanomaterial, chromium, bovine serum amine oxidase, polyamine biosensor, hepatocellular carcinoma, bovine serum amine oxidase

59. Enlightening mineral iron sensing in Pseudomonas fluorescens by surface active maghemite nanoparticles: Involvement of the OprF porin

Author

Magro, Massimiliano, Fasolato, Luca, Bonaiuto, Emanuela, Andreani, Nadia, Baratella, Davide, Corraducci, Vittorino, Miotto, Giovanni, Cardazzo, Barbara, Vianello, Fabio, Magro, Massimiliano, Fasolato, Luca, Bonaiuto, Emanuela, Andreani, Nadia, Baratella, Davide, Corraducci, Vittorino, Miotto, Giovanni, Cardazzo, Barbara, and Vianello, Fabio

Abstract

Background: Mineral iron(III) recognition by bacteria is considered a matter of debate. The peculiar surface chemistry of novel naked magnetic nanoparticles, called SAMNs (surface active maghemite nanoparticles) characterized by solvent exposed Fe3+ sites on their surface, was exploited for studying mineral iron sensing in Pseudomonas fluorescens. Methods: SAMNs were applied for mimicking Fe3+ ions in solution, acting as magnetically drivable probes to evaluate putative Fe3+ recognition sites on the microorganism surface. Culture broths and nano-bio-conjugates were characterized by UV–Vis spectroscopy and mass spectrometry. Results: The whole heritage of a membrane porin (OprF) of P. fluorescens Ps_22 cells was recognized and firmly bound by SAMNs. The binding of nanoparticles to OprF porin was correlated to a drastic inhibition of a siderophore (pyoverdine) biosynthesis and to the stimulation of the production and rate of formation of a secondary siderophore. The analysis of metabolic pathways, based on P. fluorescens Ps_22 genomic information, evidenced that this putative secondary siderophore does not belong to a selection of the most common siderophores. Conclusions: In the scenario of an adhesion mechanism, it is plausible to consider OprF as the biological component deputed to the mineral iron sensing in P. fluorescens Ps_22, as well as one key of siderophore regulation. General significance: The present work sheds light on mineral iron sensing in microorganisms. Peculiar colloidal naked iron oxide nanoparticles offer a useful approach for probing the adhesion of bacterial surface on mineral iron for the identification of the specific recognition site for this iron uptake regulation in microorganisms.

60. Primary biliary cholangitis: perception and expectation of illness

Author

Annarosa Floreani, Michela Scaffidi, Barbara Coco, Edoardo Giovanni Giannini, Sara Labanca, Emanuela Bonaiuto, Sara De Martin, Pietro Invernizzi, Marco Carbone, Domenico Alvaro, Maria Consiglia Bragazzi, Vincenza Calvaruso, Valentina Cossiga, Nora Cazzagon, Floreani, Annarosa, Scaffidi, Michela, Coco, Barbara, Giannini, Edoardo Giovanni, Labanca, Sara, Bonaiuto, Emanuela, De Martin, Sara, Invernizzi, Pietro, Carbone, Marco, Alvaro, Domenico, Bragazzi, Maria Consiglia, Calvaruso, Vincenza, Cossiga, Valentina, and Cazzagon, Nora

Subjects
Quality of life, Motivation, Hepatology, Cholangitis, Liver Cirrhosis, Biliary, Gastroenterology, Illness perception, Humans, Perception, PBC, Questionnaire, Fatigue
Abstract

Unlabelled: An important tool to explore personal experience of symptoms, treatment and clinical outcome is stratification of illness perception in patients affected by PBC. Aim: To assess the perception of illness in a cohort of Italian patients with PBC. Methods: Between June and December 2019, a specific questionnaire was administered to a pool of 210 patients from 7 tertiary Italian centers, in order to identify and assess the patient's past history, symptoms and their impact on the quality of life, follow-up, treatment and perceived satisfaction of patients toward the provided care. Results: Fatigue, pruritus, and abdominal discomfort and sicca syndrome were present in 50.4%, 45%, 30.4% and 28.5% of patients, fatigue having the most impacting the daily-life. After a consultation with a specialist, the diagnosis of PBC was met within 18 months for 143 patients. Patients were mostly concerned about possible health problems that occur and in 25% of cases, symptoms had a negative impact on their life. Eighty percent of patients said they were satisfied with efficacy and tolerability of treatment, while 26% requested an improvement in the relationship with the specialist. Conclusions: The results highlight the importance of both promoting timely referral to the specialist and facilitating communication between healthcare professionals and patients.

Published
2022

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