51. Laser processing of polymer constructs from poly(3-hydroxybutyrate).
- Author
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Volova TG, Tarasevich AA, Golubev AI, Boyandin AN, Shumilova AA, Nikolaeva ED, and Shishatskaya EI
- Subjects
- Animals, Bone Marrow Cells ultrastructure, Cell Adhesion, Cell Survival, Cells, Cultured, Cupriavidus necator metabolism, Elastic Modulus, Humans, Hydroxybutyrates metabolism, Lasers, Gas, Mesenchymal Stem Cells ultrastructure, Mice, NIH 3T3 Cells, Polyesters metabolism, Polymers metabolism, Polymers radiation effects, Porosity, Rats, Wistar, Surface Properties, Tensile Strength, Bone Marrow Cells cytology, Hydroxybutyrates chemistry, Membranes, Artificial, Mesenchymal Stem Cells cytology, Polyesters chemistry, Polymers chemistry, Tissue Scaffolds chemistry
- Abstract
CO2 laser radiation was used to process poly(3-hydroxybutyrate) constructs - films and 3D pressed plates. Laser processing increased the biocompatibility of unperforated films treated with moderate uniform radiation, as estimated by the number and degree of adhesion of NIH 3T3 mouse fibroblast cells. The biocompatibility of perforated films modified in the pulsed mode did not change significantly. At the same time, pulsed laser processing of the 3D plates produced perforated scaffolds with improved mechanical properties and high biocompatibility with bone marrow-derived multipotent, mesenchymal stem cells, which show great promise for bone regeneration.
- Published
- 2015
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