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54. Differential Transcriptome Response to Proton (PT) Versus X-ray Radiation Identify PPARgamma as a Candidate Target for Combinatorial PT Therapy in Lymphoma

Author

Sertorio, M.G.B., primary, Nowrouzi, A., additional, Akbarpour, M., additional, Chetal, K., additional, Salomonis, N., additional, Brons, S., additional, Mascia, A.E., additional, McCauley, S., additional, Köthe, A., additional, Debus, J., additional, Perentesis, J.P., additional, Abdollahi, A., additional, Zheng, Y., additional, and Wells, S.I., additional

Published
2020
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60. Design and realization of an optimal current sensitive CCC

Author

Sese, Javier, Rietveld, Gert, Camon, Agustin, Rillo, Conrado, Vargas, Laura, Christian G., Brons, S., Hiddink, G.H., Flokstra, Jaap, Rogala, Horst, Jaszczuk, Wieslaw, and Altenburg, Horst

Subjects
Comparator circuits -- Design and construction, Electric measurements -- Research, Superconducting quantum interference devices -- Research, Electric transformers -- Research
Published
1999

61. Infants with and without orofacial clefts: how their faces grow in 3D

Author

Brons, S., Kuijpers-Jagtman, A.M., Berge, S.J., Maal, T.J.J., and Radboud University Nijmegen

Subjects
Radboud Institute for Health Sciences, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Reconstructive and regenerative medicine [Radboudumc 10]
Abstract

Contains fulltext : 210165.pdf (Publisher’s version ) (Open Access) Radboud University, 03 december 2019 Promotores : Kuijpers-Jagtman, A.M., Berge, S.J., Maal, T.J.J.

Published
2019

62. Measurement of the polarization of $$\Lambda ^0 , \overline \Lambda ^0 , \Sigma ^ + $$ and Ξ− produced in a Σ− beam of 330 GeV/c

Author

Adamovich, M. I., Albertson, E., Alexandrov, Yu. A., Barberis, D., Bérat, C., Beusch, W., Brenzinger, K. H., Brons, S., Bruckner, W., Brunengo, A., Buénerd, M., Charignon, F., Chauvin, J., Chudakov, E. A., Dameri, M., Dropmann, F., Engelfried, J., Faller, F., French, B. R., Gerassimov, S. G., Godbersen, M., Grafström, P., Hostachy, J. Y., Hurst, R. B., Kallakowsky, Th., Kluth, S., Lauber, H. M., Lennert, P., Ljungfelt, S., Martens, K., Martin, Ph., Michaels, R., Müller, U., Newsom, C., Osculati, B., Paul, S., Povh, B., Rey-Campagnolle, M., Rieseberg, H., Rohrich, K., Rosner, G., Rossi, L., Rudolph, H., Scheel, C., Schmitt, L., Siebert, H. -W., Simon, A., Trombini, A., Touillon, R., Volkemer, B., Walcher, Th., Wälder, G., Wenzel, A., and Zavertyaev, M. V.

Published
1995
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63. Soft photon production in 450 GeV/cp-Be collisions

Author

Antos, J., Beker, H., Brons, S., Bussmann, K., Dagan, S., Drees, A., Erd, C., Esten, M. J., Fabjan, C. W., Glässel, P., Goerlach, U., Hedberg, V., Lissauer, D., Mazzoni, M. A., McCubbin, N. A., Neubert, M., Nevski, P., Olsen, L., Pfeiffer, A., Ray, A., Schukraft, J., Shapira, D., Soltani, J., Specht, H. J., Stumer, I., Thompson, J., Veenhof, R. J., Willis, W. J., and Woody, C.

Published
1993
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64. Three-dimensional facial development of children with unilateral cleft lip and palate during the first year of life in comparison with normative average faces

Author

Brons, S., Meulstee, J.W., Loonen, T.G.J., Nada, R.M., Kuijpers, M.A.R., Bronkhorst, E.M., Berge, S.J., Maal, T.J.J., Kuijpers-Jagtman, A.M., Brons, S., Meulstee, J.W., Loonen, T.G.J., Nada, R.M., Kuijpers, M.A.R., Bronkhorst, E.M., Berge, S.J., Maal, T.J.J., and Kuijpers-Jagtman, A.M.

Abstract

Contains fulltext : 206749.pdf (publisher's version ) (Open Access)

Published
2019

65. Influence of involuntary facial expressions on reproducibility of 3D stereophotogrammetry in children with and without complete unilateral cleft lip and palate from 3 to 18 months of age

Author

Brons, S., Darroudi, Amir, Nada, Rania, Bronkhorst, E.M., Vreeken, R.D., Berge, S.J., Maal, T., Kuijpers-Jagtman, A.M., Brons, S., Darroudi, Amir, Nada, Rania, Bronkhorst, E.M., Vreeken, R.D., Berge, S.J., Maal, T., and Kuijpers-Jagtman, A.M.

Abstract

Contains fulltext : 204008.pdf (publisher's version ) (Open Access)

Published
2019

66. Infants with and without orofacial clefts: how their faces grow in 3D

Author

Kuijpers-Jagtman, A.M., Berge, S.J., Maal, T.J.J., Brons, S., Kuijpers-Jagtman, A.M., Berge, S.J., Maal, T.J.J., and Brons, S.

Abstract

Radboud University, 3 december 2019, Promotores : Kuijpers-Jagtman, A.M., Berge, S.J., Maal, T.J.J., Contains fulltext : 210165.pdf (publisher's version ) (Open Access)

Published
2019

69. Observation of a resonance in the KSp decay channel at a mass of 1765 MeV/c2

Author

Adamovich, M.I., Alexandrov, Y.A., Baranov, S.P., Barberis, D., Beck, M., Bérat, C., Beusch, W., Boss, M., Brons, S., Brückner, W., Buénerd, M., Busch, C., Büscher, C., Charignon, F., Chauvin, J., Chudakov, E.A., Dersch, U., Dropmann, F., Engelfried, J., Faller, F., Fournier, A., Gerassimov, S.G., Godbersen, M., Grafström, P., Haller, T., Heidrich, M., Hubbard, E., Hurst, R.B., Königsmann, K., Konorov, I., Keller, N., Martens, K., Martin, P., Masciocchi, S., Michaels, R., Müller, U., Neeb, H., Newbold, D., Newsom, C., Paul, S., Pochodzalla, J., Potashnikova, I., Povh, B., Ren, Z., Rey-Campagnolle, M., Rosner, G., Rossi, L., Rudolph, H., Scheel, C., Schmitt, L., Siebert, H.-W., Simon, A., Smith, V., Thilmann, O., Trombini, A., Vesin, E., Volkemer, B., Vorwalter, K., Walcher, T., Wälder, G., Werding, R., Wittmann, E., and Zavertyaev, M.V.

Published
2007
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73. A follow-up of the FOM fusion FEM for 1 MW, 1 s

Author

Verhoeven, A.G.A, Bongers, W.A, Bratman, V.L, Brons, S, Denisov, G.G, van der Geer, C.A.J, van der Geer, S.B, Kruijt, O.G, de Loos, M.J, Manintveld, P, Poelman, A.J, Plomp, J, Savilov, A.V, Smeets, P.H.M, and Urbanus, W.H

Published
2001
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74. Atrioventricular node ablation in langendorff-perfused porcine hearts using carbon ion particle therapy

Author

Lehmann H. I., Richter D., Prokesch H., Graeff C., Prall M., Simoniello P., Fournier C., Bauer J., Kaderka R., Weymann A., Szabo G., Sonnenberg K., Constantinescu A. M., Johnson S. B., Misiri J., Takami M., Miller R. C., Herman M. G., Asirvatham S. J., Brons S., Jakel O., Haberer T., Debus J., Durante M., Bert C., Packer D. L., Lehmann, H. I., Richter, D., Prokesch, H., Graeff, C., Prall, M., Simoniello, P., Fournier, C., Bauer, J., Kaderka, R., Weymann, A., Szabo, G., Sonnenberg, K., Constantinescu, A. M., Johnson, S. B., Misiri, J., Takami, M., Miller, R. C., Herman, M. G., Asirvatham, S. J., Brons, S., Jakel, O., Haberer, T., Debus, J., Durante, M., Bert, C., and Packer, D. L.

Subjects
carbon particle therapy, atrioventricular node, catheter-free ablation, Atrial fibrillation, tachycardia, ventricular
Abstract

Particle therapy, with heavy ions such as carbon-12 (12 C), delivered to arrhythmogenic locations of the heart could be a promising new means for catheter-free ablation. As a first investigation, we tested the feasibility of in vivo atrioventricular node ablation, in Langendorff-perfused porcine hearts, using a scanned 12C beam. Methods and Results-Intact hearts were explanted from 4 (30-40 kg) pigs and were perfused in a Langendorff organ bath. Computed tomgraphic scans (1 mm voxel and slice spacing) were acquired and 12 C ion beam treatment planning (optimal accelerator energies, beam positions, and particle numbers) for atrioventricular node ablation was conducted. Orthogonal X-rays with matching of 4 implanted clips were used for positioning. Ten Gray treatment plans were repeatedly administered, using pencil beam scanning. After delivery, positron emission tomography-computed tomgraphic scans for detection of β + (11 C) activity were obtained. A 12 C beam with a full width at half maximum of 10 mm was delivered to the atrioventricular node. Delivery of 130 Gy caused disturbance of atrioventricular conduction with transition into complete heart block after 160 Gy. Positron emission computed tomgraphy demonstrated dose delivery into the intended area. Application did not induce arrhythmias. Macroscopic inspection did not reveal damage to myocardium. Immunostaining revealed strong γH2AX signals in the target region, whereas no γH2AX signals were detected in the unirradiated control heart. Conclusions-This is the first report of the application of a 12 C beam for ablation of cardiac tissue to treat arrhythmias. Catheter-free ablation using 12C beams is feasible and merits exploration in intact animal studies as an energy source for arrhythmia elimination.

Published
2015

76. Ion recombination correction factor in scanned light-ion beams for absolute dose measurement using plane-parallel ionisation chambers

Author

UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service de radiothérapie oncologique, UCL - (SLuc) Centre du cancer, Rossomme, S, Horn, J, Brons, S, Jäkel, O, Mairani, A, Ciocca, M, Floquet, V, Romano, F, Rodriguez Garcia, D, Vynckier, S, Palmans, H, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service de radiothérapie oncologique, UCL - (SLuc) Centre du cancer, Rossomme, S, Horn, J, Brons, S, Jäkel, O, Mairani, A, Ciocca, M, Floquet, V, Romano, F, Rodriguez Garcia, D, Vynckier, S, and Palmans, H

Abstract

Based on international reference dosimetry protocols for light-ion beams, a correction factor (k s) has to be applied to the response of a plane-parallel ionisation chamber, to account for recombination of negative and positive charges in its air cavity before these charges can be collected on the electrodes. In this work, k s for IBA PPC40 Roos-type chambers is investigated in four scanned light-ion beams (proton, helium, carbon and oxygen). To take into account the high dose-rates used with scanned beams and LET-values, experimental results are compared to a model combining two theories. One theory, developed by Jaffé, describes the variation of k s with the ionization density within the ion track (initial recombination) and the other theory, developed by Boag, describes the variation of k s with the dose rate (volume recombination). Excellent agreement is found between experimental and theoretical k s-values. All results confirm that k s cannot be neglected. The solution to minimise k s is to use the ionisation chamber at high voltage. However, one must be aware that charge multiplication may complicate the interpretation of the measurement. For the chamber tested, it was found that a voltage of 300 V can be used without further complication. As the initial recombination has a logarithmic variation as a function of 1/V, the two-voltage method is not applicable to these scanned beams.

Published
2017

77. Optimization of carbon ion treatment plans by integrating tissue specific α/β-values for patients with non-resectable pancreatic cancer

Author

Dreher, C., Scholz, C., Pommer, M., Brons, S., Prokesch, H., Ecker, S., Debus, J., Jäkel, O., Combs, S.E., and Habermehl, D.

Abstract

Background: The aim of the thesis is to improve treatment plans of carbon ion irradiation by integrating the tissues' specific α/β-values for patients with locally advanced pancreatic cancer (LAPC). Material and Methods: Five patients with LAPC were included in this study. By the use of the treatment planning system Syngo RT Planning (Siemens, Erlangen, Germany) treatment plans with carbon ion beams have been created. Dose calculation was based on α/β-values for both organs at risk (OAR) and the tumor. Twenty-five treatment plans and thirty-five forward calculations were created. With reference to the anatomy five field configurations were included. Single Beam Optimization (SBO) and Intensity Modulated Particle Therapy (IMPT) were used for optimization. The plans were analyzed with respect to both dose distributions and individual anatomy. The plans were evaluated using a customized index. Results: With regard to the target, a field setup with one single posterior field achieves the highest score in our index. Field setups made up of three fields achieve good results in OAR sparing. Nevertheless, the field setup with one field is superior in complex topographic conditions. But, allocating an α/β-value of 2 Gy to the spinal cord leads to critical high maximum doses in the spinal cord. The evaluation of dose profiles showed significant dose peaks at borders of the α/β-gradient, especially in case of a single posterior field. Conclusion: Optimization with specific α/β-values allows a more accurate view on dose distribution than previously. A field setup with one single posterior field achieves good results in case of difficult topographic conditions, but leads to high maximum doses to the spinal cord. So, field setups with multiple fields seem to be more adequate in case of LAPC, being surrounded by highly radiosensitive normal tissues.

Published
2016

89. Fragmentation of 120 and 200 MeV u−14He ions in water and PMMA targets

Author

Rovituso, M, primary, Schuy, C, additional, Weber, U, additional, Brons, S, additional, Cortés-Giraldo, M A, additional, La Tessa, C, additional, Piasetzky, E, additional, Izraeli, D, additional, Schardt, D, additional, Toppi, M, additional, Scifoni, E, additional, Krämer, M, additional, and Durante, M, additional

Published
2017
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92. Proton Interaction Vertex Imaging for carbon therapy quality control

Author

Rescigno, R., Jerome Baudot, Brons, S., Dauvergne, D., Finck, C., Juliani, D., Krimmer, J., Parodi, K., Ray, C., Reithinger, V., Rinaldi, I., Marc Rousseau, Testa, E., Winter, M., Rayet, Béatrice, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Heidelberg Ion Beam Therapy Center - HIT, Heidelberg University Clinic, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Radiation Therapy and Radiation Oncology, and University clinic Heidelberg

Abstract

International audience; Purpose: In the framework of the 12C based hadrontherapy, the monitoring of the ion range is a crucial issue for the quality control of the treatments. An emerging method to perform a real-time monitoring exploits secondary charged particle radiation. Simulations have shown that the number of emerging protons is enough to perform ion-range monitoring in homogeneous targets on a pencil-beam basis operating in active mode. The variation of vertex distributions have been recently confirmed by an experiment performed with clinical beam and a PMMA target. The present study aims at comparing simulations and measurements obtained with homogeneous and heterogeneous target.

Published
2014

94. Charge asymmetries for D, ${\rm D_s}$ and $\Lambda_{\rm c}$ production in $\sigma^-$ -nucleus interactions at 340 GeV/c

Author

Adamovich, M.I., Alexandrov, Y.A., Barberis, D., Beck, M., Berat, C., Beusch, W., Boss, M., Brons, S., Bruckner, W., Buenerd, M., Busch, C., Buscher, C., Charignon, F., Chauvin, J., Chudakov, E.A., Dersch, U., Dropmann, F., Engelfried, J., Faller, F., Fournier, A., Gerassimov, S.G., Godbersen, M., Grafstrom, P., Haller, T., Heidrich, M., Hubbard, E., Hurst, R.B., Konigsmann, Kay, Konorov, I., Keller, N., Martens, K., Martin, P., Masciocchi, S., Michaels, R., Muller, U., Neeb, H., Newbold, D., Newsom, C., Paul, S., Pochodzalla, J., Potashnikova, I., Povh, B., Ransome, R., Ren, Z., Rey-Campagnolle, M., Rosner, G., Rossi, L., Rudolph, H., Scheel, C., Schmitt, L., Siebert, H.W., Simon, A., Smith, V.J., Thilmann, O., Trombini, A., Vesin, E., Volkemer, B., Vorwalter, K., Walcher, T., Walder, G., Werding, R., Wittmann, E., and Zavertyaev, M.V.

Subjects
Quark, Physics, Particle physics, Large Hadron Collider, Physics and Astronomy (miscellaneous), High Energy Physics::Lattice, High Energy Physics::Phenomenology, FOS: Physical sciences, Sigma, Charge (physics), Lambda, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), medicine.anatomical_structure, medicine, Physics::Accelerator Physics, High Energy Physics::Experiment, Production (computer science), Nuclear Experiment, Engineering (miscellaneous), Nucleus, Particle Physics - Experiment, Beam (structure)
Abstract

CERN experiment WA89 has studied charmed particles produced by a Sigma^- beam at 340 GeV/c on nuclear targets. Production of particles which have light quarks in common with the beam is compared to production of those which do not. Considerable production asymmetries between D^- and D^p, D_s^ and D_s^+ and Lambda_c and Antilambda_c are observed. The results are compared with pion beam data and with theoretical calculations., LaTeX ; 16 pages including 4 ps figures

Published
1999
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