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482 results on '"Caccamo, Daniela"'

51. Is Melatonin the Cornucopia of the 21st Century?

Author

Ferlazzo, Nadia, primary, Andolina, Giulia, additional, Cannata, Attilio, additional, Costanzo, Maria Giovanna, additional, Rizzo, Valentina, additional, Currò, Monica, additional, Ientile, Riccardo, additional, and Caccamo, Daniela, additional

Published
2020
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54. Intracellular Fate and Impact on Gene Expression of Doxorubicin/Cyclodextrin-Graphene Nanomaterials at Sub-Toxic Concentration

Author

Caccamo, Daniela, primary, Currò, Monica, additional, Ientile, Riccardo, additional, Verderio, Elisabetta AM, additional, Scala, Angela, additional, Mazzaglia, Antonino, additional, Pennisi, Rosamaria, additional, Musarra-Pizzo, Maria, additional, Zagami, Roberto, additional, Neri, Giulia, additional, Rosmini, Consolato, additional, Potara, Monica, additional, Focsan, Monica, additional, Astilean, Simion, additional, Piperno, Anna, additional, and Sciortino, Maria Teresa, additional

Published
2020
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62. Search for Novel Diagnostic Biomarkers of Prostate Inflammation-Related Disorders: Role of Transglutaminase Isoforms as Potential Candidates

Author

Savoca, Maria Pia, Inferrera, Antonino, Verderio, Elisabetta A. M., and Caccamo, Daniela

Subjects
Article Subject
Abstract

Investigations on prostate inflammation-related disorders, including acute and chronic prostatitis, chronic pelvic pain syndrome, benign prostate hyperplasia (BPH), and prostate cancer (PCa), are still ongoing to find new, accurate, and noninvasive biomarkers for a differential diagnosis of those pathological conditions sharing some common macroscopic features. Moreover, an ideal biomarker should be useful for risk assessment of prostate inflammation progression to more severe disorders, like BPH or PCa, as well as for monitoring of treatment response and prognosis establishment in carcinoma cases. Recent literature evidence highlighted that changes in the expression of transglutaminases, enzymes that catalyze transamidation reactions leading to posttranslational modifications of soluble proteins, occur in prostate inflammation-related disorders. This review focuses on the role specifically played by transglutaminases 4 (TG4) and 2 (TG2) and suggests that both isoenzymes hold a potential to be included in the list of candidates as novel diagnostic biomarkers for the above-cited prostate pathological conditions.

Published
2019
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64. Correction: D'Amico et al. Consumption of Cashew (Anacardium occidentale L.) Nuts Counteracts Oxidative Stress and Tissue Inflammation in Mild Hyperhomocysteinemia in Rats. Nutrients 2022, 14 , 1474.

Author

D'Amico, Ramona, Cordaro, Marika, Fusco, Roberta, Peritore, Alessio Filippo, Genovese, Tiziana, Gugliandolo, Enrico, Crupi, Rosalia, Mandalari, Giuseppina, Caccamo, Daniela, Cuzzocrea, Salvatore, Di Paola, Rosanna, Siracusa, Rosalba, and Impellizzeri, Daniela

Abstract

A correction is presented to the article the original publication, addressing a misunderstanding in Figure 5, where the authors replaced Figure 5 panel D to rectify the error in antibody incubation on consecutive sections from the same sample, with the clarification that the scientific conclusions.

Published
2024
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67. Association of Higher Advanced Oxidation Protein Products (AOPPs) Levels in Patients with Diabetic and Hypertensive Nephropathy

Author

Conti, Giovanni, primary, Caccamo, Daniela, additional, Siligato, Rossella, additional, Gembillo, Guido, additional, Satta, Ersilia, additional, Pazzano, Dario, additional, Carucci, Nicolina, additional, Carella, Antonio, additional, Del Campo, Giuliana, additional, Salvo, Antonino, additional, and Santoro, Domenico, additional

Published
2019
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69. Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation

Author

Russo, Tiziana, primary, Currò, Monica, additional, Ferlazzo, Nadia, additional, Caccamo, Daniela, additional, Perrone, Patrizia, additional, Arena, Salvatore, additional, Antonelli, Enrica, additional, Antonuccio, Pietro, additional, Ientile, Riccardo, additional, Romeo, Carmelo, additional, and Impellizzeri, Pietro, additional

Published
2019
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70. NF-kappaB activation is associated with homocysteine-induced injury in Neuro2a cells

Author

Ientile Riccardo, Parisi Giulia, Currò Monica, Condello Salvatore, Ferlazzo Nadia, and Caccamo Daniela

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Abstract Background Perinatal exposure to hyperhomocysteinemia might disturb neurogenesis during brain development and growth. Also, high levels of homocysteine trigger neurodegeneration in several experimental models. However, the putative mechanisms of homocysteine-induced toxicity in the developing nervous system have poorly been elucidated. This study was aimed to investigate homocysteine effects in undifferentiated neuroblastoma cells, Neuro2a. Results A 4 h exposure to homocysteine in a concentration range of 10–100 μM did not affect cell viability and ROS production in Neuro2a cell cultures. Instead, ROS levels were increased by two-three folds in cells treated with 250 μM and 500 μM homocysteine, respectively, in comparison with control cells. Also, the highest homocysteine dose significantly reduced the viable cell number by 40%. Notably, the treatment with homocysteine (250 μM–500 μM) in the presence of antioxidants, such as N-acetylcysteine and IRFI 016, a synthetic α-tocopherol analogue, recovered cell viability and significantly reduced homocysteine-evoked increases in ROS production. Moreover, antioxidants, particularly IRFI 016, were able to counteract NF-κB activation induced by 250 μM homocysteine. Cell treatment with 250 μM homocysteine also triggered the onset of apoptosis, as demonstrated by the increased expression of early apoptotic markers such as Bax, caspase-3 and p53. In contrast, Bcl2 expression was not affected by homocysteine exposure. Interestingly, the specific inhibition of NF-κB nuclear translocation by the synthetic peptide SN50 was able to almost completely suppress the homocysteine-evoked rises in pro-apoptotic protein expression as well as in caspase-3 activity. Further, also IRFI 016 and N-acetylcysteine were able to significantly reduce caspase-3 activation induced by homocysteine treatment. Conclusion These observations suggest an involvement of redox state alterations and activated NF-κB in apoptosis onset triggered by homocysteine in neuroblastoma cells Neuro2a. However, further investigations are needed to characterize molecular events involved in the NF-κB activation induced by homocysteine.

Published
2008
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71. CO2 Pneumoperitoneum Effects on Molecular Markers of Tumor Invasiveness in SH-SY5Y Neuroblastoma Cells.

Author

Montalto, Angela Simona, Currò, Monica, Russo, Tiziana, Ferlazzo, Nadia, Caccamo, Daniela, Ientile, Riccardo, Romeo, Carmelo, and Impellizzeri, Pietro

Subjects
NEUROBLASTOMA, CANCER invasiveness, TUMOR markers, MESSENGER RNA, VASCULAR endothelial growth factors, PNEUMOPERITONEUM, ENDOSCOPIC surgery, PROTEOLYTIC enzymes, CELL physiology, RNA, CELLULAR signal transduction, CARBON dioxide, CELL lines
Abstract

Introduction:  CO2 pneumoperitoneum can influence the biological behavior of neuroblastoma (NB). Angiogenesis and genetic features are responsible for malignant phenotype of this tumor. We examined the CO2 effects on N-Myc, vascular endothelial growth factor (VEGF), and matrix metalloproteinase-2 (MMP-2) expression as critical biomarkers of tumor invasiveness, in NB cells without N-Myc amplification.Materials and Methods:  SH-SY5Y cells were exposed to CO2 (100%) at 15 mm Hg pressure for 4 hours and then moved to normal condition for 24 hours. Control cells were incubated with 5% CO2 for the same time. In control and CO2-exposed cells, the messenger ribonucleic acid (mRNA) levels of hypoxia-inducible factor (HIF)-1α, HIF-2α, VEGF-A, and MMP-2 were quantified by real-time polymerase chain reaction. N-Myc expression was evaluated by Western blot analysis.Results:  The exposure to 15 mm Hg CO2 (100%) for 4 hours induced an increase in HIF-1α, but not in HIF-2α, mRNA levels. No differences were observed in N-Myc expression between exposed and control cells at each incubation time. Similarly, no significant differences were found for VEGF-A and MMP-2 transcript levels. In CO2 exposed cells, we observed only a slight increase in both VEGF-A and MMP-2 mRNA levels after 4 and 24 hours in comparison to controls.Conclusion:  In our study, the hypoxic environment induced by CO2 exposure does not affect the expression of critical biomarkers of NB aggressiveness, such as N-Myc, VEGF, and MMP-2, in human SH-SY5Y NB cells without N-Myc amplification. These data suggest that CO2 pneumoperitoneum might not adversely impact NB cell invasiveness; however, it is necessary to evaluate these effects in others in vitro and in vivo models. [ABSTRACT FROM AUTHOR]

Published
2020
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77. Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans

Author

Currò, Monica, primary, Russo, Tiziana, additional, Ferlazzo, Nadia, additional, Caccamo, Daniela, additional, Antonuccio, Pietro, additional, Arena, Salvatore, additional, Parisi, Saveria, additional, Perrone, Patrizia, additional, Ientile, Riccardo, additional, Romeo, Carmelo, additional, and Impellizzeri, Pietro, additional

Published
2018
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81. Neuroprotective effects of phloretin and its glycosylated derivative on rotenone-induced toxicity in human SH-SY5Y neuronal-like cells

Author

Barreca, Davide, primary, Currò, Monica, additional, Bellocco, Ersilia, additional, Ficarra, Silvana, additional, Laganà, Giuseppina, additional, Tellone, Ester, additional, Laura Giunta, Maria, additional, Visalli, Giuseppa, additional, Caccamo, Daniela, additional, Galtieri, Antonio, additional, and Ientile, Riccardo, additional

Published
2017
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85. Monitoring of cardiovascular risk factors in competitive athletes

Author

DI MAURO, Debora, Curro', Monica, D’Amico, F., Vecchio, M., Caccamo, Daniela, Ientile, Riccardo, Buda, Diego, Bruschetta, Daniele, and Trimarchi, Fabio

Subjects
cardiovascular risk factors, physical activity, homocysteine, cardiovascular risk factors, homocysteine, physical activity, Homocysteine, competitive athletes
Abstract

It is well known that physical activity can improve cardiovascular risk factors, but it is also true that strenuous activity may result detrimental for the athlete health. Among the emerging markers of cardiovascular risk, plasma homocysteine (Hcy) plays a prominent role, since it has been shown its significant increase in competitive athletes. Some research has concluded that Hcy levels may be influenced by the duration, intensity and type of exercise, whereas other studies have identified lifestyle factors, such as smoking, eating habits, alcohol consumption, age, elevated blood pressure and genetic factors, as factors that contribute to increased plasma concentrations of Hcy. Polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) (677C/T, 1298A/C) are reported to modulate homocysteine levels. The aim of this work was to identify a genetic profile of risk for cardiovascular disease in two populations of competitive athletes, football players (n = 19) and those engaged in athletics (n=37). The distribution of MTHFR A1298C and C677T polymorphisms was examined by Real-time PCR allelic discrimination on genomic DNA isolated from lymphocytes of whole peripheral blood. The serum levels of Hcy were determined by HPLC method, while vitamin B12 and folate by RIA technique. The data showed that 50% of the subjects in both groups are carrier of MTHFR C677T polymorphism either in heterozygous or homozygous state. In addition, all subjects had mild hyperhomocysteinemia (13-27 micromol/L). The highest mean levels of Hcy were recorded in the football players, and the differences compared to those engaged in athletics were very significant (21.8 ± 11.6 vs. 13.5 ± 6.6, p, Italian Journal of Anatomy and Embryology, Vol 119, No 1 (Supplement) 2014

Published
2015
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87. Resveratrol protects against homocysteine-induced cell damage via cell stress response in neuroblastoma cells

Author

Curro', Monica, Angela, Trovato Salinaro, Gugliandolo, Agnese, Guido, Koverech, Francesca, Lodato, Caccamo, Daniela, Vittorio, Calabrese, and Ientile, Riccardo

Subjects
Analysis of Variance, Microscopy, Confocal, Cell Death, Hsp70, cell stress response, neuroprotection, resveratrol, sirtuin 1, Gene Expression Regulation, Neoplastic, Neuroblastoma, Oxidative Stress, Neuroprotective Agents, Sirtuin 1, Resveratrol, Cell Line, Tumor, Stilbenes, Humans, HSP70 Heat-Shock Proteins, Reactive Oxygen Species, Homocysteine, DNA Damage
Abstract

Recent findings underscore that some natural compounds are responsible for specific biochemical effects, i.e., the activation of redox-sensitive intracellular pathways and modulation of different stress proteins, such as heat shock proteins and sirtuins. Resveratrol, a natural polyphenol widely present in plants, has been shown to display various beneficial effects, including neuroprotection, in several pathological conditions. In the present study, by using differentiated SH-SY5Y neuroblastoma cells, we investigated the potential protective effects of resveratrol against homocysteine-induced neurotoxicity. We observed that homocysteine (100 µM) decreased cell viability while at the same time significantly increasing intracellular reactive oxygen species and DNA fragmentation. Cell pretreatment with resveratrol concentrations ranging from 1 to 5 µM elicited protective effects through the reduction of oxidative stress and genotoxic damage. In addition, we observed that resveratrol produced significant changes in the expression of both Hsp70 and sirtuin 1 (SIRT1). After homocysteine treatment in the presence of resveratrol, SIRT1 protein was found abundantly not only in the cytosol but also in the nucleus, as demonstrated by confocal laser scanning microscopy. The results of this study suggest that resveratrol is a potential protective agent against homocysteine-induced neurotoxicity and that beneficial effects are accompanied by changes in cell stress response. Taken together, these features contribute to our knowledge of underlying mechanisms involved in resveratrol-induced cell survival.

Published
2014

90. Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans

Author

Russo, Tiziana, primary, Currò, Monica, additional, Barbera, Anna, additional, Caccamo, Daniela, additional, Antonuccio, Pietro, additional, Arena, Salvatore, additional, Montalto, Angela, additional, Parisi, Saveria, additional, Marseglia, Lucia, additional, Gitto, Eloisa, additional, Ientile, Riccardo, additional, Impellizzeri, Pietro, additional, and Romeo, Carmelo, additional

Published
2016
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93. MP463FGF23 KINETICS AND REMOVAL ON HAEMODIAFILTRATION

Author

Cernaro, Valeria, primary, Lucisano, Silvia, additional, Canale, Valeria, additional, Bruzzese, Annamaria, additional, Caccamo, Daniela, additional, Costantino, Giuseppe, additional, Buemi, Michele, additional, and Santoro, Domenico, additional

Published
2016
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94. Oxidative Stress and Advanced Glycation End Products in Hashimoto's Thyroiditis

Author

Ruggeri, Rosaria M., primary, Vicchio, Teresa M., additional, Cristani, Mariateresa, additional, Certo, Rosaria, additional, Caccamo, Daniela, additional, Alibrandi, Angela, additional, Giovinazzo, Salvatore, additional, Saija, Antonina, additional, Campennì, Alfredo, additional, Trimarchi, Francesco, additional, and Gangemi, Sebastiano, additional

Published
2016
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96. The rs237887 single nucleotide polymorphism in oxytocin receptor gene and the risk for mood disorders in Italian population: A case-control study

Author

Bruno, Antonio, primary, Gangemi, Chiara, additional, Gugliandolo, Agnese, additional, Crucitti, Manuela, additional, Currò, Monica, additional, Cedro, Clemente, additional, Pandolfo, Gianluca, additional, Caccamo, Daniela, additional, A. Zoccali, Rocco, additional, and R.A. Muscatello, Maria, additional

Published
2016
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