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51. Additional file 1 of Outcome of haploidentical versus matched sibling donors in hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Nagler, Arnon, Labopin, Myriam, Houhou, Mohamed, Aljurf, Mahmoud, Ashrafsadat Mousavi, Rose-Marie Hamladji, Zahrani, Mohsen Al, Bondarenko, Sergey, Arat, Mutlu, Angelucci, Emanuele, Koc, Yener, Gülbas, Zafer, Sica, Simona, Bourhis, Jean Henri, Canaani, Jonathan, Eolia Brissot, Giebel, Sebastian, and Mohty, Mohamad

Abstract

Additional file 1: Appendix.

Published
2021
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52. Venetoclax combinations induce high response rates in newly diagnosed acute myeloid leukemia patients ineligible for intensive chemotherapy in routine practice

Author

Apel, Arie, primary, Moshe, Yakir, additional, Ofran, Yishai, additional, Gural, Alexander, additional, Wolach, Ofir, additional, Ganzel, Chezi, additional, Canaani, Jonathan, additional, Zektser, Miri, additional, Duek, Adrian, additional, Stemer, Galia, additional, Hellman, Ilana, additional, Basood, May, additional, Frisch, Avraham, additional, Leibovitch, Chiya, additional, and Koren‐Michowitz, Maya, additional

Published
2021
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54. Outcome of T‐cell–replete haploidentical stem cell transplantation improves with time in adults with acute lymphoblastic leukemia: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Nagler, Arnon, primary, Labopin, Myriam, additional, Koc, Yener, additional, Angelucci, Emanuele, additional, Tischer, Johanna, additional, Arat, Mutlu, additional, Pioltelli, Pietro, additional, Bernasconi, Paolo, additional, Chiusolo, Patrizia, additional, Diez‐Martin, J. L., additional, Sanz, Jamie, additional, Ciceri, Fabio, additional, Peric, Zinaida, additional, Giebel, Sebastian, additional, Canaani, Jonathan, additional, and Mohty, Mohamad, additional

Published
2021
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55. The Role of Cytogenetic Risk Stratification in FLT3 Mutated NPM1 Negative AML Patients Undergoing Allogeneic Stem Cell Transplantation (alloSCT) in Remission: A Study on Behalf of the ALWP of the EBMT

Author

Nagler, Arnon, primary, Labopin, Myriam, additional, Craddock, Charles, additional, Socié, Gerard, additional, Yakoub-Agha, Ibrahim, additional, Gedde-Dahl, Tobias, additional, Niittyvuopio, Riitta, additional, Byrne, J., additional, Cornelissen, Jan, additional, Labussière-Wallet, Hélène, additional, Arcese, William, additional, Milpied, Noel, additional, Canaani, Jonathan, additional, Esteve, Jordi, additional, and Mohty, Mohamad, additional

Published
2021
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56. Non T–Cell Depleted Haploidentical Versus Matched Sibling Donor Hematopoietic Stem Cell Transplantation in Adult Patients with Acute Lymphoblastic Leukemia in Remission: A Study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Nagler, Arnon, primary, Labopin, Myriam, additional, Houhou, Mohamed, additional, Aljurf, Mahmoud Deeb, additional, Mousavi, Ashrafsadat, additional, Hamladji, Rose-Marie, additional, Alzahrani, Mohsen, additional, Bondarenko, Sergey N., additional, Arat, Mutlu, additional, Angelucci, Emanuele, additional, Koc, Yener, additional, Gülbas, Zafer, additional, Sica, Simona, additional, Bourhis, Jean Henri, additional, Canaani, Jonathan, additional, Brissot, Eolia, additional, Giebel, Sebastian, additional, and Mohty, Mohamad, additional

Published
2021
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57. Comparison of Haploidentical Bone Marrow versus Matched Unrelated Donor Peripheral Blood Stem Cell Transplantation with Posttransplant Cyclophosphamide in Patients with Acute Leukemia

Author

Nagler, Arnon, primary, Labopin, Myriam, additional, Dholaria, Bhagirathbhai, additional, Angelucci, Emanuele, additional, Afanasyev, Boris, additional, Cornelissen, Jan J., additional, Sica, Simona, additional, Meijer, Ellen, additional, Ciceri, Fabio, additional, Van Gorkom, Gwendolyn, additional, Kröger, Nicolaus, additional, Martin, Hans, additional, Pioltelli, Pietro, additional, Risitano, Antonio, additional, Canaani, Jonathan, additional, Savani, Bipin N., additional, Sanz, Jaime, additional, and Mohty, Mohamad, additional

Published
2021
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60. First Results from a Nationwide Prospective Non-Interventional Study of Venetoclax-Based 1st Line Therapies in Patients with Acute Myeloid Leukemia (AML) - Revive Study

Author

Wolach, Ofir, primary, Levi, Itai, additional, Canaani, Jonathan, additional, Tadmor, Tamar, additional, Tavor, Sigal, additional, Hellmann, Ilana, additional, Zuckerman, Tsila, additional, Lavie, David, additional, Stemer, Galia, additional, Cohen, Raanan, additional, Afik, Ran, additional, Ofek, Keren, additional, Banayan, Hilla, additional, Kan, Inna, additional, Grunspan, Moshe, additional, Ofran, Yishai, additional, and Moshe, Yakir, additional

Published
2020
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64. Cytogenetic risk score maintains its prognostic significance in AML patients with detectable measurable residual disease undergoing transplantation in remission: On behalf of the acute leukemia working party of the European society for blood and marrow transplantation

Author

Nagler, Arnon, primary, Labopin, Myriam, additional, Canaani, Jonathan, additional, Niittyvuopio, Riitta, additional, Socié, Gerard, additional, Kröger, Nicolaus, additional, Itäla‐Remes, Maija, additional, Yakoub‐Agha, Ibrahim, additional, Labussière‐Wallet, Hélène, additional, Gallego‐Hernanz, Maria P., additional, Deconinck, Eric, additional, Chevallier, Patrice, additional, Finke, Jürgen, additional, Esteve, Jordi, additional, and Mohty, Mohamad, additional

Published
2020
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65. Reassessing the role of high dose cytarabine and mitoxantrone in relapsed/refractory acute myeloid leukemia

Author

Canaani, Jonathan, primary, Nagar, Meital, additional, Heering, Gabriel, additional, Gefen, Chen, additional, Yerushalmi, Ronit, additional, Shem-Tov, Noga, additional, Volchek, Yulia, additional, Merkel, Drorit, additional, Avigdor, Abraham, additional, Shimoni, Avichai, additional, Amariglio, Ninette, additional, Rechavi, Gidi, additional, and Nagler, Arnon, additional

Published
2020
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66. Two‐dimensional speckle‐tracking strain detects subclinical cardiotoxicity in older patients treated for acute myeloid leukemia

Author

Cascino, Gregory J., primary, Voss, Woo Bin, additional, Canaani, Jonathan, additional, Furiasse, Nicholas, additional, Rademaker, Alfred, additional, Ky, Bonnie, additional, Luger, Selina, additional, Altman, Jessica K., additional, Foran, James M., additional, Litzow, Mark R., additional, Tallman, Martin S., additional, Rigolin, Vera, additional, and Akhter, Nausheen, additional

Published
2019
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67. The mTOR inhibitor everolimus overcomes CXCR4-mediated resistance to histone deacetylase inhibitor panobinostat through inhibition of p21 and mitotic regulators

Author

Beider, Katia, primary, Bitner, Hanna, additional, Voevoda-Dimenshtein, Valeria, additional, Rosenberg, Evgenia, additional, Sirovsky, Yaarit, additional, Magen, Hila, additional, Canaani, Jonathan, additional, Ostrovsky, Olga, additional, Shilo, Noya, additional, Shimoni, Avichai, additional, Abraham, Michal, additional, Weiss, Lola, additional, Milyavsky, Michael, additional, Peled, Amnon, additional, and Nagler, Arnon, additional

Published
2019
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70. T-cell replete haploidentical stem cell transplantation attenuates the prognostic impact of FLT3-ITD in acute myeloid leukemia. A report from the Acute Leukemia Working Party of the EBMT

Author

Canaani, Jonathan, Labopin, Myriam, Huang, Xiao-Jun, Arcese, William, Ciceri, Fabio, Blaise, Didier, Irrera, Giuseppe, Lopez Corral, Lucia, Bruno, Benedetto, Santarone, Stella, Van Lint, Maria Teresa, Vitek, Antonin, Esteve, Jordi, Mohty, Mohamad, and Nagler, Arnon

Subjects
Acute myeloid leukemia, FLT3-ITD, haploidentical hematopoietic stem cell transplantation
Published
2018

72. Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia

Author

McMahon, Christine M., primary, Ferng, Timothy, additional, Canaani, Jonathan, additional, Wang, Eunice S., additional, Morrissette, Jennifer J.D., additional, Eastburn, Dennis J., additional, Pellegrino, Maurizio, additional, Durruthy-Durruthy, Robert, additional, Watt, Christopher D., additional, Asthana, Saurabh, additional, Lasater, Elisabeth A., additional, DeFilippis, RosaAnna, additional, Peretz, Cheryl A.C., additional, McGary, Lisa H.F., additional, Deihimi, Safoora, additional, Logan, Aaron C., additional, Luger, Selina M., additional, Shah, Neil P., additional, Carroll, Martin, additional, Smith, Catherine C., additional, and Perl, Alexander E., additional

Published
2019
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74. Defining the Prognostic Implications of Recurring Cytogenetic Aberrations and FLT3-ITD in Acute Myeloid Leukemia Patients Undergoing Allogeneic Stem Cell Transplantation: On Behalf of the ALWP of the EBMT

Author

Canaani, Jonathan, primary, Labopin, Myriam, additional, Itälä-Remes, Maija, additional, Blaise, Didier, additional, Socié, Gerard, additional, Forcade, Edouard, additional, Maertens, Johan A., additional, Wu, Depei, additional, Malladi, Ram, additional, Cornelissen, Jan, additional, Huynh, Anne, additional, Bourhis, Jean Henri, additional, Esteve, Jordi, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2019
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76. A phase II study of bisantrene in patients with relapsed/refractory acute myeloid leukemia.

Author

Canaani, Jonathan, Danylesko, Ivetta, Shemtov, Noga, Zlotnick, Maya, Lozinsky, Kira, Benjamini, Ohad, Yerushalmi, Ronit, Nagar, Meital, Dor, Chen, Shimoni, Avichai, Avigdor, Abraham, and Nagler, Arnon

Subjects
*ACUTE myeloid leukemia, *STEM cell transplantation, *INTRAVENOUS therapy, *BONE marrow, *NUCLEOTIDE sequencing
Abstract

Objectives: To determine the current role of bisantrene, an anthracene with anthracycline‐like activity which was shown in earlier studies to be effective therapy in relapsed/refractory acute myeloid leukemia with no discernible cardiotoxicity, in the treatment of patients with R/R AML. Methods: This phase 2, single‐center study (NCT03820908) enrolled adult R/R AML to receive bisantrene (250 mg/m2 daily for 7 days) which was administered via an intravenous infusion over 2 hours on days 1‐7. Disease assessment included routine blood work and bone marrow studies. Results: In all, 10 patients were enrolled with a median of 3 lines of prior therapy including seven patients who had relapsed following allogeneic stem cell transplantation. The most frequently reported grade ≥3 treatment‐attributed hematologic AE was thrombocytopenia, whereas the most frequently reported grade ≥3 treatment‐attributed non‐hematologic AE was mucositis. Of the 10 patients, one (10%) achieved a complete remission and three patients achieved a partial remission resulting in an overall response rate of 40%. Next‐generation sequencing of patient samples identified a wide array of mutations associated with activated signaling, splicing, and epigenetic modification. Conclusions: In view of the observed low toxicity, a follow‐up study combining bisantrene with complementary anti‐leukemic therapy is planned. [ABSTRACT FROM AUTHOR]

Published
2021
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77. 58 - The Role of Cytogenetic Risk Stratification in FLT3 Mutated NPM1 Negative AML Patients Undergoing Allogeneic Stem Cell Transplantation (alloSCT) in Remission: A Study on Behalf of the ALWP of the EBMT

Author

Nagler, Arnon, Labopin, Myriam, Craddock, Charles, Socié, Gerard, Yakoub-Agha, Ibrahim, Gedde-Dahl, Tobias, Niittyvuopio, Riitta, Byrne, J., Cornelissen, Jan, Labussière-Wallet, Hélène, Arcese, William, Milpied, Noel, Canaani, Jonathan, Esteve, Jordi, and Mohty, Mohamad

Published
2021
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78. Minimal residual disease status predicts outcome of acute myeloid leukaemia patients undergoing T-cell replete haploidentical transplantation. An analysis from the Acute Leukaemia Working Party (ALWP) of the European Society for Blood and Marrow Transplan

Author

Canaani, Jonathan, primary, Labopin, Myriam, additional, Huang, Xiao J., additional, Ciceri, Fabio, additional, Van Lint, Maria T., additional, Bruno, Benedetto, additional, Santarone, Stella, additional, Diez-Martin, José L., additional, Blaise, Didier, additional, Chiusolo, Patrizia, additional, Wu, Depei, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2018
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79. Comparison of FLAMSA-based reduced intensity conditioning with treosulfan/fludarabine conditioning for patients with acute myeloid leukemia: an ALWP/EBMT analysis

Author

Sheth, Vipul, primary, Labopin, Myriam, additional, Canaani, Jonathan, additional, Volin, Liisa, additional, Brecht, Arne, additional, Ganser, Arnold, additional, Mayer, Jiri, additional, Labussière-Wallet, Hélène, additional, Bittenbring, Jörg, additional, Shouval, Roni, additional, Savani, Bipin, additional, Mohty, Mohammad, additional, and Nagler, Arnon, additional

Published
2018
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80. T‐cell replete haploidentical stem cell transplantation attenuates the prognostic impact of FLT3‐ITD in acute myeloid leukemia: A report from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Canaani, Jonathan, primary, Labopin, Myriam, additional, Huang, Xiao‐Jun, additional, Arcese, William, additional, Ciceri, Fabio, additional, Blaise, Didier, additional, Irrera, Giuseppe, additional, Corral, Lucia Lopez, additional, Bruno, Benedetto, additional, Santarone, Stella, additional, Van Lint, Maria Teresa, additional, Vitek, Antonin, additional, Esteve, Jordi, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2018
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81. Minimal Residual Disease Status in Acute Myeloid Leukemia Patients Undergoing T-Cell Replete Haploidentical Transplantation. an Analysis From the Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (Ebmt)

Author

Canaani, Jonathan, primary, Labopin, Myriam, additional, Huang, Xiao Jun, additional, Ciceri, Fabio, additional, Van Lint, Maria Teresa, additional, Bruno, Benedetto, additional, Santarone, Stella, additional, Diez-Martin, José Luis, additional, Blaise, Didier, additional, Sica, Simona, additional, Wu, Depei, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2018
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82. Outcome of Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Acute Myeloid Leukemia over 70 Years of Age: On Behalf of the Acute Leukemia Working Party of the EBMT

Author

Ringden, Olle, primary, Boumendil, Ariane, additional, Labopin, Myriam, additional, Canaani, Jonathan, additional, Sadeghi, Behnam, additional, Beelen, Dietrich W., additional, Ehninger, Gerhard, additional, Niederwieser, Dietger, additional, Finke, Jürgen, additional, Stelljes, Matthias, additional, Arnold, Renate, additional, Ganser, Arnold, additional, Kroger, Nicolaus, additional, Kanz, Lothar, additional, Brecht, Arne, additional, Savani, Bipin N., additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2018
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83. Donor Age Determines Outcome in Acute Leukemia Patients Undergoing Haploidentical Hematopoietic Cell Transplantation

Author

Canaani, Jonathan, primary, Savani, Bipin N., additional, Labopin, Myriam, additional, Huang, Xiao Jun, additional, Ciceri, Fabio, additional, Arcese, William, additional, Koc, Yener, additional, Tischer, Johanna, additional, Blaise, Didier, additional, Gulbas, Zafer, additional, Van Lint, Maria Teresa, additional, Bruno, Benedetto, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2017
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84. Donor age determines outcome in acute leukemia patients over 40 undergoing haploidentical hematopoietic cell transplantation

Author

Canaani, Jonathan, primary, Savani, Bipin N., additional, Labopin, Myriam, additional, Huang, Xiao‐Jun, additional, Ciceri, Fabio, additional, Arcese, William, additional, Koc, Yener, additional, Tischer, Johanna, additional, Blaise, Didier, additional, Gülbas, Zafer, additional, Van Lint, Maria Teresa, additional, Bruno, Benedetto, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2017
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85. Allogeneic stem cell transplantation in acute lymphoblastic leukemia patients older than 60 years: a survey from the acute leukemia working party of EBMT

Author

Roth-Guepin, Gabrielle, primary, Canaani, Jonathan, additional, Ruggeri, Annalisa, additional, Labopin, Myriam, additional, Finke, Juergen, additional, Cornelissen, Jan J., additional, Delage, Jeremy, additional, Stuhler, Gernot, additional, Rovira, Monserrat, additional, Potter, Mike, additional, Stadler, Michael, additional, Veelken, Hendrik, additional, Cahn, Jean Yves, additional, Collin, Matthew, additional, Beguin, Yves, additional, Giebel, Sebastian, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2017
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86. Dissecting the mechanisms involved in anti-human T-lymphocyte immunoglobulin (ATG)-induced tolerance in the setting of allogeneic stem cell transplantation - potential implications for graft versus host disease

Author

Beider, Katia, primary, Naor, David, additional, Voevoda, Valeria, additional, Ostrovsky, Olga, additional, Bitner, Hanna, additional, Rosenberg, Evgenia, additional, Varda-Bloom, Nira, additional, Marcu-Malina, Victoria, additional, Canaani, Jonathan, additional, Danilesko, Ivetta, additional, Shimoni, Avichai, additional, and Nagler, Arnon, additional

Published
2017
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87. Serum AChE Activities Predict Exercise Heart Rate Parameters of Asymptomatic Individuals

Author

Yakobi Reut, Soreq Hermona, Weiskopf Nir, Ben Assayag Einor, Shenhar-Tsarfaty Shani, Canaani Jonathan, and Berliner Shlomo

Subjects
medicine.medical_specialty, Future studies, Aché, business.industry, Treadmill exercise, Routine practice, Asymptomatic, Acetylcholinesterase, language.human_language, Peripheral, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, Heart rate, medicine, Cardiology, language, medicine.symptom, business
Abstract

Background specific heart rate parameters notably associate with variable risks of cardiovascular disease and mortality, however, to date there are no readily available blood tests associated with these parameters. Because of the established parasympathetic contributions towards cardiac regulation, we challenged the working hypothesis that serum acetylcholinesterase (AChE) activity is involved. Methods A total of 403 Healthy men and women were included in the study and underwent treadmill exercise testing. Prior to exercise testing the subject’s serum AChE activity levels were assessed by measuring rates of acetylthiocholine hydrolysis. Results In male subjects AChE activity was positively correlated to resting heart rate (r = 0.210, p = 0.001). Complementing this observation, AChE activity was negatively correlated to the exercise-induced heart rate increase (r = –0.181, p = 0.005) and to heart rate recovery at 1, 2 and 5 minutes following cessation of exercise (r = –0.150, p = 0.022; r = –0.157, p = 0.016; r = –0.176, p = 0.008 respectively). This indicated that lower than average AChE activities, which presumably reflect increased peripheral ACh levels, might be correlated to favorable heart rate parameters. Similar observations were made in female subjects, except for lack of correlation to their resting heart rate. Additionally, we observed that we were able to stratify subjects into two groups of significantly different AChE activity (p = 0.001) based on a cut point of heart rate recovery below 20 beats one minute after cessation of exercise. Conclusion In asymptomatic individuals lower than average AChE activity is associated with favorable indices of exercise-inducible heart rate increase as well as heart rate recovery. Future studies will be needed to evaluate the added prognostic significance gained by implementing this marker into routine practice.

Published
2010

88. ABO incompatibility in mismatched unrelated donor allogeneic hematopoietic cell transplantation for acute myeloid leukemia: A report from the acute leukemia working party of the EBMT

Author

Canaani, Jonathan, primary, Savani, Bipin N., additional, Labopin, Myriam, additional, Michallet, Mauricette, additional, Craddock, Charles, additional, Socié, Gerard, additional, Volin, Lisa, additional, Maertens, Johan A., additional, Crawley, Charles, additional, Blaise, Didier, additional, Ljungman, Per T., additional, Cornelissen, Jan, additional, Russell, Nigel, additional, Baron, Frédéric, additional, Gorin, Norbert, additional, Esteve, Jordi, additional, Ciceri, Fabio, additional, Schmid, Christoph, additional, Giebel, Sebastian, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2017
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89. Long term impact of hyperleukocytosis in newly diagnosed acute myeloid leukemia patients undergoing allogeneic stem cell transplantation: An analysis from the acute leukemia working party of the EBMT

Author

Canaani, Jonathan, primary, Labopin, Myriam, additional, Socié, Gerard, additional, Nihtinen, Anne, additional, Huynh, Anne, additional, Cornelissen, Jan, additional, Deconinck, Eric, additional, Gedde-Dahl, Tobias, additional, Forcade, Edouard, additional, Chevallier, Patrice, additional, Bourhis, Jean H., additional, Blaise, Didier, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2017
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90. Impact of ABO incompatibility on patients’ outcome after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia - a report from the Acute Leukemia Working Party of the EBMT

Author

Canaani, Jonathan, primary, Savani, Bipin N, additional, Labopin, Myriam, additional, Huang, Xiao-jun, additional, Ciceri, Fabio, additional, Arcese, William, additional, Tischer, Johanna, additional, Koc, Yener, additional, Bruno, Benedetto, additional, Gülbas, Zafer, additional, Blaise, Didier, additional, Maertens, Johan, additional, Ehninger, Gerhard, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2017
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91. ABO Mismatching and Haploidentical Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia—a Report from the ALWP of the EBMT

Author

Savani, Bipin N., primary, Labopin, Myriam, additional, Canaani, Jonathan, additional, Huang, Xiao-Jun, additional, Arcese, William, additional, Tischer, Johanna, additional, Koc, Yener, additional, Bruno, Benedetto, additional, Gulbas, Zafer, additional, Blaise, Didier, additional, Maertens, Johan A., additional, Ehninger, Gerhard, additional, Baron, Frédéric, additional, Gorin, Norbert, additional, Esteve, Jordi, additional, Schmid, Christoph, additional, Giebel, Sebastian, additional, Ciceri, Fabio, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2017
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92. Impact of ABO-Mismatching Following HLA- Mismatched Unrelated Donor Hematopoietic Stem Cell Transplantation for AML—a Report From the ALWP of the EBMT

Author

Savani, Bipin N., primary, Labopin, Myriam, additional, Canaani, Jonathan, additional, Michallet, Mauricette, additional, Craddock, Charles, additional, Socié, Gerard, additional, Volin, Liisa, additional, Maertens, Johan A., additional, Crawley, Charles, additional, Blaise, Didier, additional, Ljungman, Per T., additional, Cornelissen, Jan, additional, Russell, Nigel, additional, Baron, Frédéric, additional, Gorin, Norbert, additional, Esteve, Jordi, additional, Ciceri, Fabio, additional, Schmid, Christoph, additional, Giebel, Sebastian, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2017
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93. Impact of FAB classification on predicting outcome in acute myeloid leukemia, not otherwise specified, patients undergoing allogeneic stem cell transplantation in CR1: An analysis of 1690 patients from the acute leukemia working party of EBMT

Author

Canaani, Jonathan, primary, Beohou, Eric, additional, Labopin, Myriam, additional, Socié, Gerard, additional, Huynh, Anne, additional, Volin, Liisa, additional, Cornelissen, Jan, additional, Milpied, Noel, additional, Gedde-Dahl, Tobias, additional, Deconinck, Eric, additional, Fegueux, Nathalie, additional, Blaise, Didier, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2017
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94. Impact of FAB Classification on Predicting Outcome in Acute Myeloid Leukemia, Not Otherwise Specified, Patients Undergoing Allogeneic Stem Cell Transplantation in CR1: An Analysis of 1690 Patients from the Acute Leukemia Working Party of EBMT

Author

Canaani, Jonathan, primary, Beohou, Eric, additional, Labopin, Myriam, additional, Socie, Gerard, additional, Huynh, Anne, additional, Volin, Liisa, additional, Cornelissen, Jan J., additional, Milpied, Noel, additional, Gedde-Dahl, Tobias, additional, Deconinck, Eric, additional, Delage, Jeremy, additional, Blaise, Didier, additional, Mohty, Mohamad, additional, and Nagler, Arnon, additional

Published
2016
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95. Gilteritinib and Venetoclax for Relapsed/Refractory FLT3-Mutated Acute Myeloid Leukemia - a Real-World Multicenter Retrospective Study

Author

Kugler, Eitan, Cohen, Inbar, Ram, Ron, Canaani, Jonathan, Amitai, Irina, Shargian, Liat, Nachmias, Boaz, Krayem, Baher, Frisch, Avraham, Levi, Itay, Akria, Luiza, Raanani, Pia, Wolach, Ofir, and Kugler, Eitan

Abstract

Introduction:Relapsed/Refractory (R/R) FLT3-mutated AML is a challenging clinical scenario with a dismal outcome. Gilteritinib, a selective and potent oral FLT3 tyrosine kinase inhibitor (TKI), is approved for treatment of FLT3 mutated R/R AML, and was shown to improve response rates and overall survival (OS) as compared to standard chemotherapy (Perl et al, NEJM 2019). However, remission rates and long-term survival with gilteritinib monotherapy are still unsatisfactory, highlighting the need for new therapies to improve patient outcomes.

Published
2023
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96. Cytomegalovirus infection and thrombosis: coincidence or connection?

Author

Atzmony, Lihi, Mashav, Nao, Saar, Nili, Canaani, Jonathan, Kliuk-Ben-Bassat, Orit, Halutz, Ora, Paran, Yael, Steinvil, Arie, and Justo, Dan

Subjects
Cross infection -- Risk factors, Cross infection -- Research, Nosocomial infections -- Risk factors, Nosocomial infections -- Research, Blood clot -- Risk factors, Blood clot -- Diagnosis, Blood clot -- Drug therapy, Blood clot -- Research, Thrombosis -- Risk factors, Thrombosis -- Diagnosis, Thrombosis -- Drug therapy, Thrombosis -- Research, Ganciclovir -- Health aspects, Ganciclovir -- Usage, Cytomegalovirus infections -- Risk factors, Cytomegalovirus infections -- Drug therapy, Cytomegalovirus infections -- Research, Immunocompromised host -- Diseases, Immunocompromised host -- Medical examination, Health
Abstract

Introduction:Sporadic cases of concomitant acute cytomegalovirus (CMV) infection and thrombosis have been reported several times in the past. However,the incidence of thrombosis among patients with acute CMV infection has never been studied. Moreover, since acute CMV infection is common, it might be diagnosed in patients suffering from thrombosis without actually triggering it.Aim: To study the incidence of thrombosis among patients with acute CMV infection hospitalized in a tertiary medical center. Among these patients, we compare the incidence of CMV-induced thrombosis with that of CMV-accompanied thrombosis.Methods: Medical charts and imaging study reports of all patients diagnosed with acute CMV infection during the years 2005-2006 were reviewed for the presence of thrombosis and for its acquired as well as inherited predisposition.Results: Overall 160 patients were diagnosed with acute CMV infection during the years 2005-2006. Six (3.8%) of these patients were diagnosed concomitantly with thrombosis. Of these patients, four were immunocompromised. Either the acute CMV infection or the thrombosis was diagnosed incidentally in all of these patients. Acquired predispositions for thrombosis, other than acute CMV infection, were present in four of them. Hence, the incidence of CMV-induced thrombosis and CMV-accompanied thrombosis was 1.3% and 2.5%, respectively. Conclusions: Though thrombosis among patients with acute CMV infection is not rare, it is unclear whether CMV actually triggered thrombosis in most of these cases. A case controlled study is needed to confirm the association between acute CMV infection and thrombosis. Keywords: Cytomegalovirus | Ganciclovir | Thrombosis, Introduction Concomitant acute cytomegalovirus (CMV) infection and thrombosis has been reported several times in medical literature. Though mainly seen in immunocompromised patients, it has been reported in immunocompetent patients as [...]

Published
2009

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