353 results on '"Carpentier C"'
Search Results
52. P06.19 TERT promoter mutation is an independent prognostic factor in 1p/19q co-deleted oligodendrogliomas: a POLA network study
- Author
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Alentorn, A., primary, Carpentier, C., additional, Labreche, K., additional, Ducray, F., additional, Dehais, C., additional, Mokhtari, K., additional, Uro-Coste, E., additional, Figarella-Branger, D., additional, Delattre, J., additional, and Idbaih, A., additional
- Published
- 2016
- Full Text
- View/download PDF
53. The Hellenistic-Nabataean Crypt in Tower Tomb 303 at Ath-Thughrah in Petra. Results of the Archaeological and Multi-Disciplinary Studies
- Author
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Sachet, I., Delhopital, N., Bouchaud, C., Tomé Carpentier, C., Archéozoologie, archéobotanique : sociétés, pratiques et environnements (AASPE), and Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)
- Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2013
54. Integration of rehabilitation technologies impact into river basin management - Collaborative management tool REACHER
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van Griensven, A., Broeckx, S., Haest, P.J., Kwast van Der, J., Dinkneh, A., Getahun, S., Yunqing, X., Hoang, L., Carpentier, C., Jesenska, S., Blaha, L., Boucard, Pierre, Slobodnik, Jaroslav, Bastiaens, L., Seuntjens, P., Flemish Institute for Technological Research (VITO), Research Centre for Toxic Compounds in the Environment, Masaryk University [Brno] (MUNI), Environmental Institute, Institut National de l'Environnement Industriel et des Risques (INERIS), and Civs, Gestionnaire
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[SDE] Environmental Sciences ,REMEDIATION ,GROUNDWATER ,WATER MANAGEMENT ,[SDE]Environmental Sciences ,REACTIVE IRON PARTICLES ,VIPARIAN ZONES - Published
- 2012
55. Mis-splicing of Tau exon 10 in myotonic dystrophy type I is reproduced by overexpression of CELF2 but not by MBNL1 silencing
- Author
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Dhaenens, C.M., Tran, H., Frandemiche, M.-L., Carpentier, C., Schraen-Maschke, S., Sistiaga, A., Goicoechea, M., Eddarkaoui, S., Van Brussels, E., Obriot, H., Labudeck, A., Gevaert, M.H., Fernandez-Gomez, F., Charlet-Berguerand, N., Deramecourt, V., Maurage, C.A., Buée, Luc, De Munain, A. Lopez, Sablonnière, B., Caillet-Boudin, M.L., Sergeant, Nicolas, Peer, Hal, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Experimental Unit, Donostia Hospital, Neurological Unit, Département de neurologie [Lille], Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Etude des mécanismes moléculaires à la base des dystrophies myotoniques, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Département de neurologie[Lille], and Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)
- Subjects
musculoskeletal diseases ,congenital, hereditary, and neonatal diseases and abnormalities ,Neurofibrillary degeneration ,Microtubule-associated protein Tau ,CELF splicing factor family ,Myotonic dystrophy ,[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology ,Triplet expansion disease ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,Splicing ,MBNL1 - Abstract
International audience; Tau is the proteinaceous component of intraneuronal aggregates common to neurodegenerative diseases called Tauopathies, including myotonic dystrophy type I (DM1). In DM1, the presence of microtubule-associated protein Tau aggregates is associated with a mis-splicing of Tau. A toxic gain-of-function at the RNA level is a major etiological factor responsible for the mis-splicing of several transcripts in DM1. These are probably the consequence of a loss of MBNL1 function or gain of CELF1 splicing function. Whether these two dysfunctions occur together or separately, and whether all mis-splicing events in DM1 brain result from one or both of these dysfunctions remains unknown. Here, we analyzed the splicing of Tau exons 2 and 10 in the brain of DM1 patients. Two DM1 patients showed a mis-splicing of exon 10 whereas exon 2-inclusion was reduced in all DM1 patients. In order to determine the potential factors responsible for exon 10 mis-splicing, we studied the effect of the splicing factors MBNL1, CELF1, CELF2 and CELF4 or a dominant-negative CELF factor on Tau exon 10 splicing by ectopic expression or siRNA. Interestingly, the inclusion of Tau exon 10 is reduced by CELF2 whereas it is insensitive to the loss-of-function of MBNL1, CELF1 gain-of-function or a dominant-negative of CELF factor. Moreover, we observed an increased expression of CELF2 only in the brain of DM1 patients with a mis-splicing of exon 10. Taken together, our results indicate the occurrence of a mis-splicing event in DM1 that is neither induced by a loss of MBNL1 function nor a gain of CELF1 function, but is rather associated to CELF2 gain-of-function.
- Published
- 2011
56. Intravitreal bevacizumab (Avastin®) for diabetic retinopathy at 24-months: The 2008 Juan Verdaguer-planas lecture
- Author
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Arevalo J.F., Sanchez J.G., Lasave A.F., Wu L., Maia M., Bonafonte S., Brito M., Alezzandrini A.A., Restrepo N., Berrocal M.H., Saravia M., Farah M.E., Fromow-Guerra J., Morales-Canton V., Espinoza J.V., Aggio F.B., Quiroz-Mercado H., Guerrero-Naranjo J.L., Rodriguez F.J., Infante R., Medina D., Cruz-Villegas V., Graue-Wiechers F., Lozano-Rechy D., Robledo V., Rodriguez-Loaiza J.L., Roca J.A., Reategui G., Saravia M.J., Martinez-Cartier M., Avila M., Cardillo J., Costa R.A., Verdaguer J., Carpentier C., Verdaguer J.I., Filsecker D.L., Sepúlveda G., Sanchez F., Marini C., Garcia B., and Pan-American Collaborative Retina Study Group (PACORES)
- Subjects
Male ,optical coherence ,endocrine system diseases ,genetic structures ,Tractional retinal detachment ,Diabetic macular edema ,Diabetic retinopathy ,Proliferative diabetic retinopathy ,Treatment outcome ,Evaluation ,Middle aged ,Tomography ,Cell proliferation ,Priority journal ,Intravitreal injections ,Bevacizumab ,Retrospective study ,Macular thickness ,Panretinal photocoagulation ,Female ,Retina macula edema ,Human ,Monoclonal antibody ,Adult ,Retina detachment ,Visual acuity ,Angiogenesis inhibitors ,monoclonal ,Angiogenesis inhibitor ,Follow-up studies ,Article ,Antibodies ,Time ,Animals ,Humans ,Disease severity ,Aged ,Macular edema ,Optical coherence tomography ,Animal ,Time factors ,Diffuse diabetic macular edema ,Follow up ,Laser coagulation ,eye diseases ,Drug effect ,Retrospective studies ,Intravitreal drug administration ,sense organs ,Vascular endothelial growth factor ,Intravitreal bevacizumab - Abstract
Diabetic retinopathy (DR) remains the major threat to sight in the working age population. Diabetic macular edema (DME) is a manifestation of DR that produces loss of central vision. Proliferative diabetic retinopathy (PDR) is a major cause of visual loss in diabetic patients. In PDR, the growth of new vessels is thought to occur as a result of vascular endothelial growth factor (VEGF) release into the vitreous cavity as a response to ischemia. Furthermore, VEGF increases vessel permeability leading to deposition of proteins in the interstitium that facilitate the process of angiogenesis and macular edema. This review demonstrates multiple benefits of intravitreal bevacizumab (IVB) on DR including DME and PDR at 24 months of follow up. The results indicate that IVB injections may have a beneficial effect on macular thickness and visual acuity (VA) in diffuse diabetic macular edema. Therefore, in the future this new therapy could replace or complement focal/grid laser photocoagulation in DME. In PDR, this new option could be an adjuvant agent to pan-retina photocoagulation so that more selective therapy may be applied. In addition, we report a series of patients in which tractional retinal detachment developed or progressed after adjuvant preoperative IVB in severe PDR. © 2010 Bentham Science Publishers Ltd.
- Published
- 2010
57. Clinical value of chromosome arms 19q and 11p losses in low-grade gliomas
- Author
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Alentorn, A., Thuijl, H.F. van, Marie, Y., Alshehhi, H., Carpentier, C., Boisselier, B., Laigle-Donadey, F., Mokhtari, K., Scheinin, I., Wesseling, P., Ylstra, B., Capelle, L., Hoang-Xuan, K., Sanson, M., Delattre, J.Y., Reijneveld, J.C., Idbaih, A., Alentorn, A., Thuijl, H.F. van, Marie, Y., Alshehhi, H., Carpentier, C., Boisselier, B., Laigle-Donadey, F., Mokhtari, K., Scheinin, I., Wesseling, P., Ylstra, B., Capelle, L., Hoang-Xuan, K., Sanson, M., Delattre, J.Y., Reijneveld, J.C., and Idbaih, A.
- Abstract
Item does not contain fulltext, BACKGROUND: Diffuse low-grade gliomas (LGGs) form a heterogeneous subgroup of gliomas in adults. Chromosome (chr) arms 1p/19q codeletion and IDH mutation have been shown to be closely associated with oligodendroglial phenotype and better prognosis. We sought to identify relevant biomarkers in non 1p/19q codeleted LGGs. METHODS: We characterized a retrospective series of 126 LGGs using genomic arrays, microsatellite analysis, IDH sequencing, MGMT promoter methylation assay, and p53 expression analysis. RESULTS: Our study confirms that 1p/19q codeletion, mutually exclusive with p53 overexpression, was associated with: (i) better prognosis, (ii) oligodendroglial phenotype, (iii) MGMT promoter methylation, and (iv) IDH mutation. Interestingly, 1p/19q codeleted tumors occur in older patients at diagnosis. Our study shows that non 1p/19q codeleted LGGs can be divided in 5 main genomic subgroups: (i) 11p loss, (ii) 19q loss (iii) 7 gain, (iv) 19 gain, and (v) unclassified. In non 1p/19q codeleted LGGs, we demonstrated that (i) 11p loss is associated with astrocytoma phenotype and has an independent negative prognostic value, and (ii) 19q loss diminished the favorable prognostic value of IDH mutation. Our findings were validated in an independent cohort of 98 LGGs. CONCLUSION: Novel genomic entities and biomarkers have been identified in non 1p/19q codeleted LGGs. Our findings may help to stratify non 1p/19q codeleted LGGs, facilitating future individualization of treatment. Further prospective studies are warranted to support our findings.
- Published
- 2014
58. Assessing Uncertainty in Stratigraphic Correlation: A Stochastic Method Based on Dynamic Time Warping
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Edwards, J., primary, Lallier, F., additional, Caumon, G., additional, and Carpentier, C., additional
- Published
- 2014
- Full Text
- View/download PDF
59. The INRA AGENAE program and the Agenae trout EST collections: first results applied to fish physiology research
- Author
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Sandrine Aegerter, Daniel Baron, Carpentier, C., François Chauvigné, Christelle Dantec, Audrey Estampes, Anne-Sophie Goupil, Audrey Jumel, Ingrid Jutel, David Mazurais, Melaine, N., Jérôme Montfort, Julien Bobe, Patrick Chardon, Claude Chevalet, Benoit Fauconneau, Alexis Fostier, Marina Govoroun, Aurélie Le Cam, Florence Le Gac, Christophe Klopp, Stéphane Panserat, Francois PIUMI, Cécile Ralliere, Pierre-Yves Rescan, Yann Guiguen, Station commune de Recherches en Ichtyophysiologie, Biodiversité et Environnement (SCRIBE), Institut National de la Recherche Agronomique (INRA), Unité de Biométrie et Intelligence Artificielle (UBIA), Laboratoire de radiobiologie et d'étude du génome (LREG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Recherche Agronomique (INRA), Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Nutrition, Aquaculture et Génomique (NUAGE), Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Unité de Biométrie et Intelligence Artificielle (ancêtre de MIAT) (UBIA), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), and Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)
- Subjects
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,ComputingMilieux_MISCELLANEOUS ,GENOMIQUE ,SALMONIDE - Abstract
International audience
- Published
- 2004
60. Dramatic response of a BRAF V600E-mutated primary CNS histiocytic sarcoma to vemurafenib
- Author
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Idbaih, A., primary, Mokhtari, K., additional, Emile, J.-F., additional, Galanaud, D., additional, Belaid, H., additional, de Bernard, S., additional, Benameur, N., additional, Barlog, V.-C., additional, Psimaras, D., additional, Donadieu, J., additional, Carpentier, C., additional, Martin-Duverneuil, N., additional, Haroche, J., additional, Feuvret, L., additional, Zahr, N., additional, Delattre, J.-Y., additional, and Hoang-Xuan, K., additional
- Published
- 2014
- Full Text
- View/download PDF
61. O10.02 * MITOTIC INDEX, MICROVASCULAR PROLIFERATION AND NECROSIS DEFINE THREE GROUPS OF 1P/19Q CO-DELETED ANAPLASTIC OLIGODENDROGLIOMAS ASSOCIATED WITH DIFFERENT GENOMIC ALTERATIONS
- Author
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Figarella-Branger, D., primary, Mokhtari, K., additional, Dehais, C., additional, Jouvet, A., additional, Uro-Coste, E., additional, Colin, C., additional, Carpentier, C., additional, Ducray, F., additional, Idbaih, A., additional, and Network, F. P., additional
- Published
- 2014
- Full Text
- View/download PDF
62. P17.01 * CHROMOSOME ARM 9P LOSS OF HETEROZYGOSITY IS A MARKER OF SHORTER SURVIVAL IN 1P/19Q CO-DELETED ANAPLASTIC OLIGODENDROGLIOMA. A POLA NETWORK STUDY
- Author
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Alentorn, A., primary, Dehais, C., additional, Carpentier, C., additional, Mokhtari, K., additional, Ducray, F., additional, Figarella-Branger, D., additional, Delattre, J., additional, Idbaih, A., additional, and (POLA)", P. N. P. e. c. d. O. A., additional
- Published
- 2014
- Full Text
- View/download PDF
63. P14.30: The impact of low-dose aspirin on utero-placental circulation: a systematic review
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Roberge, S., primary, Carpentier, C., additional, Demers, S., additional, Tapp, S., additional, and Bujold, E., additional
- Published
- 2014
- Full Text
- View/download PDF
64. Single-cell gene expression signatures reveal melanoma cell heterogeneity
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Ennen, M, primary, Keime, C, additional, Kobi, D, additional, Mengus, G, additional, Lipsker, D, additional, Thibault-Carpentier, C, additional, and Davidson, I, additional
- Published
- 2014
- Full Text
- View/download PDF
65. Tau exon 2 responsive elements deregulated in myotonic dystrophy type I are proximal to exon 2 and synergistically regulated by MBNL1 and MBNL2
- Author
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Carpentier, C., primary, Ghanem, D., additional, Fernandez-Gomez, F.J., additional, Jumeau, F., additional, Philippe, J.V., additional, Freyermuth, F., additional, Labudeck, A., additional, Eddarkaoui, S., additional, Dhaenens, C.M., additional, Holt, I., additional, Behm-Ansmant, I., additional, Marmier-Gourrier, N., additional, Branlant, C., additional, Charlet-Berguerand, N., additional, Marie, J., additional, Schraen-Maschke, S., additional, Buée, L., additional, Sergeant, N., additional, and Caillet-Boudin, M.L., additional
- Published
- 2014
- Full Text
- View/download PDF
66. OMICS AND PROGNSTIC MARKERS
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Adachi, K., primary, Sasaki, H., additional, Nagahisa, S., additional, Yoshida, K., additional, Hattori, N., additional, Nishiyama, Y., additional, Kawase, T., additional, Hasegawa, M., additional, Abe, M., additional, Hirose, Y., additional, Alentorn, A., additional, Marie, Y., additional, Poggioli, S., additional, Alshehhi, H., additional, Boisselier, B., additional, Carpentier, C., additional, Mokhtari, K., additional, Capelle, L., additional, Figarella-Branger, D., additional, Hoang-Xuan, K., additional, Sanson, M., additional, Delattre, J.-Y., additional, Idbaih, A., additional, Yust-Katz, S., additional, Anderson, M., additional, Olar, A., additional, Eterovic, A., additional, Ezzeddine, N., additional, Chen, K., additional, Zhao, H., additional, Fuller, G., additional, Aldape, K., additional, de Groot, J., additional, Andor, N., additional, Harness, J., additional, Lopez, S. G., additional, Fung, T. L., additional, Mewes, H. W., additional, Petritsch, C., additional, Arivazhagan, A., additional, Somasundaram, K., additional, Thennarasu, K., additional, Pandey, P., additional, Anandh, B., additional, Santosh, V., additional, Chandramouli, B., additional, Hegde, A., additional, Kondaiah, P., additional, Rao, M., additional, Bell, R., additional, Kang, R., additional, Hong, C., additional, Song, J., additional, Costello, J., additional, Nagarajan, R., additional, Zhang, B., additional, Diaz, A., additional, Wang, T., additional, Bie, L., additional, Li, Y., additional, Liu, H., additional, Luyo, W. F. C., additional, Carnero, M. H., additional, Iruegas, M. E. P., additional, Morell, A. R., additional, Figueiras, M. C., additional, Lopez, R. L., additional, Valverde, C. F., additional, Chan, A. K.-Y., additional, Pang, J. C.-S., additional, Chung, N. Y.-F., additional, Li, K. K.-W., additional, Poon, W. S., additional, Chan, D. T.-M., additional, Wang, Y., additional, Ng, H.-a. K., additional, Chaumeil, M., additional, Larson, P., additional, Yoshihara, H., additional, Vigneron, D., additional, Nelson, S., additional, Pieper, R., additional, Phillips, J., additional, Ronen, S., additional, Clark, V., additional, Omay, Z. E., additional, Serin, A., additional, Gunel, J., additional, Omay, B., additional, Grady, C., additional, Youngblood, M., additional, Bilguvar, K., additional, Baehring, J., additional, Piepmeier, J., additional, Gutin, P., additional, Vortmeyer, A., additional, Brennan, C., additional, Pamir, M. N., additional, Kilic, T., additional, Krischek, B., additional, Simon, M., additional, Yasuno, K., additional, Gunel, M., additional, Cohen, A. L., additional, Sato, M., additional, Aldape, K. D., additional, Mason, C., additional, Diefes, K., additional, Heathcock, L., additional, Abegglen, L., additional, Shrieve, D., additional, Couldwell, W., additional, Schiffman, J. D., additional, Colman, H., additional, D'Alessandris, Q. G., additional, Cenci, T., additional, Martini, M., additional, Ricci-Vitiani, L., additional, De Maria, R., additional, Larocca, L. M., additional, Pallini, R., additional, Theeler, B., additional, Lang, F., additional, Rao, G., additional, Gilbert, M., additional, Sulman, E., additional, Luthra, R., additional, Eterovic, K., additional, Routbort, M., additional, Verhaak, R., additional, Mills, G., additional, Mendelsohn, J., additional, Meric-Bernstam, F., additional, Yung, A., additional, MacArthur, K., additional, Hahn, S., additional, Kao, G., additional, Lustig, R., additional, Alonso-Basanta, M., additional, Chandrasekaran, S., additional, Wileyto, E. P., additional, Reyes, E., additional, Dorsey, J., additional, Fujii, K., additional, Kurozumi, K., additional, Ichikawa, T., additional, Onishi, M., additional, Ishida, J., additional, Shimazu, Y., additional, Kaur, B., additional, Chiocca, E. A., additional, Date, I., additional, Geisenberger, C., additional, Mock, A., additional, Warta, R., additional, Schwager, C., additional, Hartmann, C., additional, von Deimling, A., additional, Abdollahi, A., additional, Herold-Mende, C., additional, Gevaert, O., additional, Achrol, A., additional, Gholamin, S., additional, Mitra, S., additional, Westbroek, E., additional, Loya, J., additional, Mitchell, L., additional, Chang, S., additional, Steinberg, G., additional, Plevritis, S., additional, Cheshier, S., additional, Xu, J., additional, Napel, S., additional, Zaharchuk, G., additional, Harsh, G., additional, Gutman, D., additional, Holder, C., additional, Colen, R., additional, Dunn, W., additional, Jain, R., additional, Cooper, L., additional, Hwang, S., additional, Flanders, A., additional, Brat, D., additional, Hayes, J., additional, Droop, A., additional, Thygesen, H., additional, Boissinot, M., additional, Westhead, D., additional, Short, S., additional, Lawler, S., additional, Bady, P., additional, Kurscheid, S., additional, Delorenzi, M., additional, Hegi, M. E., additional, Crosby, C., additional, Faulkner, C., additional, Smye-Rumsby, T., additional, Kurian, K., additional, Williams, M., additional, Hopkins, K., additional, Palmer, A., additional, Williams, H., additional, Wragg, C., additional, Haynes, H. R., additional, Kurian, K. M., additional, White, P., additional, Oka, T., additional, Jalbert, L., additional, Elkhaled, A., additional, Jensen, R., additional, Salzman, K., additional, Schabel, M., additional, Gillespie, D., additional, Mumert, M., additional, Johnson, B., additional, Mazor, T., additional, Barnes, M., additional, Yamamoto, S., additional, Ueda, H., additional, Tatsuno, K., additional, Aihara, K., additional, Bollen, A., additional, Hirst, M., additional, Marra, M., additional, Mukasa, A., additional, Saito, N., additional, Aburatani, H., additional, Berger, M., additional, Taylor, B., additional, Popov, S., additional, Mackay, A., additional, Ingram, W., additional, Burford, A., additional, Jury, A., additional, Vinci, M., additional, Jones, C., additional, Jones, D. T. W., additional, Hovestadt, V., additional, Picelli, S., additional, Wang, W., additional, Northcott, P. A., additional, Kool, M., additional, Reifenberger, G., additional, Pietsch, T., additional, Sultan, M., additional, Lehrach, H., additional, Yaspo, M.-L., additional, Borkhardt, A., additional, Landgraf, P., additional, Eils, R., additional, Korshunov, A., additional, Zapatka, M., additional, Radlwimmer, B., additional, Pfister, S. M., additional, Lichter, P., additional, Joy, A., additional, Smirnov, I., additional, Reiser, M., additional, Shapiro, W., additional, Kim, S., additional, Feuerstein, B., additional, Jungk, C., additional, Friauf, S., additional, Unterberg, A., additional, Juratli, T. A., additional, McElroy, J., additional, Meng, W., additional, Huebner, A., additional, Geiger, K. D., additional, Krex, D., additional, Schackert, G., additional, Chakravarti, A., additional, Lautenschlaeger, T., additional, Kim, B. Y., additional, Jiang, W., additional, Beiko, J., additional, Prabhu, S., additional, DeMonte, F., additional, Sawaya, R., additional, Cahill, D., additional, McCutcheon, I., additional, Lau, C., additional, Wang, L., additional, Terashima, K., additional, Yamaguchi, S., additional, Burstein, M., additional, Sun, J., additional, Suzuki, T., additional, Nishikawa, R., additional, Nakamura, H., additional, Natsume, A., additional, Terasaka, S., additional, Ng, H.-K., additional, Muzny, D., additional, Gibbs, R., additional, Wheeler, D., additional, Zhang, X.-q., additional, Sun, S., additional, Lam, K.-f., additional, Kiang, K. M. Y., additional, Pu, J. K. S., additional, Ho, A. S. W., additional, Leung, G. K. K., additional, Loebel, F., additional, Curry, W. T., additional, Barker, F. G., additional, Lelic, N., additional, Chi, A. S., additional, Cahill, D. P., additional, Lu, D., additional, Yin, J., additional, Teo, C., additional, McDonald, K., additional, Madhankumar, A., additional, Weston, C., additional, Slagle-Webb, B., additional, Sheehan, J., additional, Patel, A., additional, Glantz, M., additional, Connor, J., additional, Maire, C., additional, Francis, J., additional, Zhang, C.-Z., additional, Jung, J., additional, Manzo, V., additional, Adalsteinsson, V., additional, Homer, H., additional, Blumenstiel, B., additional, Pedamallu, C. S., additional, Nickerson, E., additional, Ligon, A., additional, Love, C., additional, Meyerson, M., additional, Ligon, K., additional, Jalbert, L. E., additional, Nelson, S. J., additional, Bollen, A. W., additional, Smirnov, I. V., additional, Song, J. S., additional, Olshen, A. B., additional, Berger, M. S., additional, Chang, S. M., additional, Taylor, B. S., additional, Costello, J. F., additional, Mehta, S., additional, Armstrong, B., additional, Peng, S., additional, Bapat, A., additional, Berens, M., additional, Melendez, B., additional, Mollejo, M., additional, Mur, P., additional, Hernandez-Iglesias, T., additional, Fiano, C., additional, Ruiz, J., additional, Rey, J. A., additional, Stadler, V., additional, Schulte, A., additional, Lamszus, K., additional, Schichor, C., additional, Westphal, M., additional, Tonn, J.-C., additional, Morozova, O., additional, Katzman, S., additional, Grifford, M., additional, Salama, S., additional, Haussler, D., additional, Olshen, A., additional, Fouse, S., additional, Nakamizo, S., additional, Sasayama, T., additional, Tanaka, H., additional, Tanaka, K., additional, Mizukawa, K., additional, Yoshida, M., additional, Kohmura, E., additional, Northcott, P., additional, Jones, D., additional, Pfister, S., additional, Otani, R., additional, Takayanagi, S., additional, Saito, K., additional, Tanaka, S., additional, Shin, M., additional, Ozawa, T., additional, Riester, M., additional, Cheng, Y.-K., additional, Huse, J., additional, Helmy, K., additional, Charles, N., additional, Squatrito, M., additional, Michor, F., additional, Holland, E., additional, Perrech, M., additional, Dreher, L., additional, Rohn, G., additional, Goldbrunner, R., additional, Timmer, M., additional, Pollo, B., additional, Palumbo, V., additional, Calatozzolo, C., additional, Patane, M., additional, Nunziata, R., additional, Farinotti, M., additional, Silvani, A., additional, Lodrini, S., additional, Finocchiaro, G., additional, Lopez, E., additional, Rioscovian, A., additional, Ruiz, R., additional, Siordia, G., additional, de Leon, A. P., additional, Rostomily, C., additional, Rostomily, R., additional, Silbergeld, D., additional, Kolstoe, D., additional, Chamberlain, M., additional, Silber, J., additional, Roth, P., additional, Keller, A., additional, Hoheisel, J., additional, Codo, P., additional, Bauer, A., additional, Backes, C., additional, Leidinger, P., additional, Meese, E., additional, Thiel, E., additional, Korfel, A., additional, Weller, M., additional, Nagae, G., additional, Nagane, M., additional, Sanborn, J. Z., additional, Mikkelsen, T., additional, Jhanwar, S., additional, Chin, L., additional, Nishihara, M., additional, Schliesser, M., additional, Grimm, C., additional, Weiss, E., additional, Claus, R., additional, Weichenhan, D., additional, Weiler, M., additional, Hielscher, T., additional, Sahm, F., additional, Wiestler, B., additional, Klein, A.-C., additional, Blaes, J., additional, Plass, C., additional, Wick, W., additional, Stragliotto, G., additional, Rahbar, A., additional, Soderberg-Naucler, C., additional, Won, M., additional, Ezhilarasan, R., additional, Sun, P., additional, Blumenthal, D., additional, Vogelbaum, M., additional, Jenkins, R., additional, Jeraj, R., additional, Brown, P., additional, Jaeckle, K., additional, Schiff, D., additional, Dignam, J., additional, Atkins, J., additional, Brachman, D., additional, Werner-Wasik, M., additional, Mehta, M., additional, Shen, J., additional, Luan, J., additional, Yu, A., additional, Matsutani, M., additional, Liang, Y., additional, Man, T.-K., additional, Trister, A., additional, Tokita, M., additional, Mikheeva, S., additional, Mikheev, A., additional, Friend, S., additional, van den Bent, M., additional, Erdem, L., additional, Gorlia, T., additional, Taphoorn, M., additional, Kros, J., additional, Wesseling, P., additional, Dubbink, H., additional, Ibdaih, A., additional, French, P., additional, van Thuijl, H., additional, Heimans, J., additional, Ylstra, B., additional, Reijneveld, J., additional, Prabowo, A., additional, Scheinin, I., additional, van Essen, H., additional, Spliet, W., additional, Ferrier, C., additional, van Rijen, P., additional, Veersema, T., additional, Thom, M., additional, Meeteren, A. S.-v., additional, Aronica, E., additional, Kim, H., additional, Zheng, S., additional, Brat, D. J., additional, Virk, S., additional, Amini, S., additional, Sougnez, C., additional, Barnholtz-Sloan, J., additional, Verhaak, R. G. W., additional, Watts, C., additional, Sottoriva, A., additional, Spiteri, I., additional, Piccirillo, S., additional, Touloumis, A., additional, Collins, P., additional, Marioni, J., additional, Curtis, C., additional, Tavare, S., additional, Tews, B., additional, Yeung, T. P. C., additional, Al-Khazraji, B., additional, Morrison, L., additional, Hoffman, L., additional, Jackson, D., additional, Lee, T.-Y., additional, Yartsev, S., additional, Bauman, G., additional, Fu, J., additional, Vegesna, R., additional, Mao, Y., additional, Heathcock, L. E., additional, Torres-Garcia, W., additional, Wang, S., additional, McKenna, A., additional, Brennan, C. W., additional, Yung, W. K. A., additional, Weinstein, J. N., additional, Sulman, E. P., additional, and Koul, D., additional
- Published
- 2013
- Full Text
- View/download PDF
67. Agricultural intensification by smallholders in the Western Brazilian Amazon: From deforestation to sustainable land use
- Author
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Vosti, S. A., Witcover, Julie, Carpentier, C. L., and Sustainable Agriculture and Natural Resource Management (SANREM) Knowledgebase
- Subjects
Sustainability ,Agricultural intensification ,Land use management ,Deforestation ,Ecosystem Farm/Enterprise Scale Field Scale ,Pasture management ,Poverty ,Amazon ,Economic growth ,Brazil - Abstract
Metadata only record This report presents trade-offs among a "critical triangle" of development objectives- environmental sustainability, economic growth, and poverty alleviation- associated with different uses of the forest in two settlement projects in the western Brazilian Amazon. It finds that settlers continue to deforest, primarily for pasture, despite strengthening legal prohibitions, improved market links to the broader economy, and rising regional incomes and welfare. A supplement to approaches that look at deforestation from a macroeconomic viewpoint, this report focuses on smallholders decision making - important because Brazilian migration policies designed to alleviate poverty have made this group a pivotal force in both deforestation and economic growth in the Amazon.
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- 2002
68. Retour d'expérience sur les PPR Inondation : la prise en compte des enjeux dans l'élaboration des PPRI
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Gendreau, N., Grelot, F., Carpentier, C., Kassouk, Z., Moreau, B., and Irstea Publications, Migration
- Subjects
[SDE] Environmental Sciences ,CEMAGREF ,HHLY ,HHLYHYD ,HHLYGER - Abstract
The notion of vulnerability remains very vague in the legislative texts. Even il the method of evaluation of this vulnerability exist, the services instructors of the Plan of Prevention of the Risks Flood (PPRI) does not use, genrally, these methods to elaborate the mandatory maps. Indeed, the PPRI objective, which is the reduction of the damages in the possessions and in the persons, does not demand socio-economic analyses of the stakes. In the rare cases where such studies are led, their purpose is to serve as a basis for discussion between the States and local governments, to reconcile the imperatives of protection and the projexts of development. Problems remain in the PPRI (method), notably the lack measures to reduce vulnerability., La notion de vulnérabilité face au phénomène inondation reste floue dans les textes législatifs. Même si des méthodes d'évaluation de cette vulnérabilité existent, les services instructeurs des Plans de Prévention des Risques d'Inondation (PPRI) n'utilisent pas, en général, ces méthodes pour élaborer la cartographie réglementaire. En effet, l'objectif affiché du PPR, la réduction des dommages aux biens et aux personnes, n'exigent pas d'analyse socio-économiques des enjeux. Dans les rares cas où de telles études sont ménées, leur finalité est de servir de base de discussion entre l'Etat et les collectivités locales, pour concilier les impératifs de protection et les projets de développement. Des problèmes subsistent dans la démarches PPR, notamment un manque de méthodologie pour prendre des mesures de réduction de la vulnéranilité.
- Published
- 2001
69. Genomic aberrations associated with outcome in anaplastic oligodendroglial tumors treated within the EORTC phase III trial 26951.
- Author
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Idbaih, A., Dalmasso, C., Kouwenhoven, M., Jeuken, J.W.M., Carpentier, C., Gorlia, T., Kros, J.M., French, P., Teepen, J., Broet, P., Delattre, O., Mokhtari, K., Sanson, M., Delattre, J.Y., Bent, M. van den, Hoang-Xuan, K., Idbaih, A., Dalmasso, C., Kouwenhoven, M., Jeuken, J.W.M., Carpentier, C., Gorlia, T., Kros, J.M., French, P., Teepen, J., Broet, P., Delattre, O., Mokhtari, K., Sanson, M., Delattre, J.Y., Bent, M. van den, and Hoang-Xuan, K.
- Abstract
1 juni 2011, Item does not contain fulltext, Despite similar morphological aspects, anaplastic oligodendroglial tumors (AOTs) form a heterogeneous clinical subgroup of gliomas. The chromosome arms 1p/19q codeletion has been shown to be a relevant biomarker in AOTs and to be perfectly exclusive from EGFR amplification in gliomas. To identify new genomic regions associated with prognosis, 60 AOTs from the EORTC trial 26951 were analyzed retrospectively using BAC-array-based comparative genomic hybridization. The data were processed using a binary tree method. Thirty-three BACs with prognostic value were identified distinguishing four genomic subgroups of AOTs with different prognosis (p < 0.0001). Type I tumors (25%) were characterized by: (1) an EGFR amplification, (2) a poor prognosis, (3) a higher rate of necrosis, and (4) an older age of patients. Type II tumors (21.7%) had: (1) loss of prognostic BACs located on 1p tightly associated with 19q deletion, (2) a longer survival, (3) an oligodendroglioma phenotype, and (4) a frontal location in brain. Type III AOTs (11.7%) exhibited: (1) a deletion of prognostic BACs located on 21q, and (2) a short survival. Finally, type IV tumors (41.7%) had different genomic patterns and prognosis than type I, II and III AOTs. Multivariate analysis showed that genomic type provides additional prognostic data to clinical, imaging and pathological features. Similar results were obtained in the cohort of 45 centrally reviewed-validated cases of AOTs. Whole genome analysis appears useful to screen the numerous genomic abnormalities observed in AOTs and to propose new biomarkers particularly in the non-1p/19q codeleted AOTs.
- Published
- 2011
70. Genomic aberrations associated with outcome in anaplastic oligodendroglial tumors treated within the EORTC phase III trial 26951
- Author
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Idbaih, A. (Ahmed), Dalmasso, C. (Cyril), Kouwenhoven, M.C.M. (Mathilde), Jeuken, J. (Judith), Carpentier, C. (Catherine), Gorlia, T.S. (Thierry), Kros, J.M. (Johan), French, P.J. (Pim), Teepen, J.L.J.M., Broët, P. (Philippe), Delattre, O. (Olivier), Mokhtari, K. (Karima), Sanson, M. (Marc), Bent, M.J. (Martin) van den, Hoang-Xuan, K. (Khe), Idbaih, A. (Ahmed), Dalmasso, C. (Cyril), Kouwenhoven, M.C.M. (Mathilde), Jeuken, J. (Judith), Carpentier, C. (Catherine), Gorlia, T.S. (Thierry), Kros, J.M. (Johan), French, P.J. (Pim), Teepen, J.L.J.M., Broët, P. (Philippe), Delattre, O. (Olivier), Mokhtari, K. (Karima), Sanson, M. (Marc), Bent, M.J. (Martin) van den, and Hoang-Xuan, K. (Khe)
- Abstract
Despite similar morphological aspects, anaplastic oligodendroglial tumors (AOTs) form a heterogeneous clinical subgroup of gliomas. The chromosome arms 1p/19q codeletion has been shown to be a relevant biomarker in AOTs and to be perfectly exclusive from EGFR amplification in gliomas. To identify new genomic regions associated with prognosis, 60 AOTs from the EORTC trial 26951 were analyzed retrospectively using BAC-array-based comparative genomic hybridization. The data were processed using a binary tree method. Thirty-three BACs with prognostic value were identified distinguishing four genomic subgroups of AOTs with different prognosis (p < 0.0001). Type I tumors (25%) were characterized by: (1) an EGFR amplification, (2) a poor prognosis, (3) a higher rate of necrosis, and (4) an older age of patients. Type II tumors (21.7%) had: (1) loss of prognostic BACs located on 1p tightly associated with 19q deletion, (2) a longer survival, (3) an oligodendroglioma phenotype, and (4) a frontal location in brain. Type III AOTs (11.7%) exhibited: (1) a deletion of prognostic BACs located on 21q, and (2) a short survival. Finally, type IV tumors (41.7%) had different genomic patterns and prognosis than type I, II and III AOTs. Multivariate analysis showed that genomic type provides additional prognostic data to clinical, imaging and pathological features. Similar results were obtained in the cohort of 45 centrally reviewed-validated cases of AOTs. Whole genome analysis appears useful to screen the numerous genomic abnormalities observed in AOTs and to propose new biomarkers particularly in the non-1p/19q codeleted AOTs.
- Published
- 2011
- Full Text
- View/download PDF
71. Genomic aberrations associated with outcome in anaplastic oligodendroglial tumors treated within the EORTC phase III trial 26951
- Author
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Idbaih, A, Dalmasso, C, Kouwenhoven, Mathilde, Jeuken, J, Carpentier, C, Gorlia, T, Kros, J.M., French, Pim, Teepen, J, Broet, P, Delattre, O, Mokhtari, K, Sanson, M, Delattre, JY, van den Bent, Martin, Hoang-Xuan, K, Idbaih, A, Dalmasso, C, Kouwenhoven, Mathilde, Jeuken, J, Carpentier, C, Gorlia, T, Kros, J.M., French, Pim, Teepen, J, Broet, P, Delattre, O, Mokhtari, K, Sanson, M, Delattre, JY, van den Bent, Martin, and Hoang-Xuan, K
- Abstract
Despite similar morphological aspects, anaplastic oligodendroglial tumors (AOTs) form a heterogeneous clinical subgroup of gliomas. The chromosome arms 1p/19q codeletion has been shown to be a relevant biomarker in AOTs and to be perfectly exclusive from EGFR amplification in gliomas. To identify new genomic regions associated with prognosis, 60 AOTs from the EORTC trial 26951 were analyzed retrospectively using BAC-array-based comparative genomic hybridization. The data were processed using a binary tree method. Thirty-three BACs with prognostic value were identified distinguishing four genomic subgroups of AOTs with different prognosis (p < 0.0001). Type I tumors (25%) were characterized by: (1) an EGFR amplification, (2) a poor prognosis, (3) a higher rate of necrosis, and (4) an older age of patients. Type II tumors (21.7%) had: (1) loss of prognostic BACs located on 1p tightly associated with 19q deletion, (2) a longer survival, (3) an oligodendroglioma phenotype, and (4) a frontal location in brain. Type III AOTs (11.7%) exhibited: (1) a deletion of prognostic BACs located on 21q, and (2) a short survival. Finally, type IV tumors (41.7%) had different genomic patterns and prognosis than type I, II and III AOTs. Multivariate analysis showed that genomic type provides additional prognostic data to clinical, imaging and pathological features. Similar results were obtained in the cohort of 45 centrally reviewed-validated cases of AOTs. Whole genome analysis appears useful to screen the numerous genomic abnormalities observed in AOTs and to propose new biomarkers particularly in the non-1p/19q codeleted AOTs.
- Published
- 2011
72. Genetic risk profiles identify different molecular etiologies for glioma
- Author
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Simon, M, Hosking, FJ, Marie, Y, Gousias, K, Boisselier, B, Carpentier, C, Schramm, J, Mokhtari, K, Hoang-Xuan, KH, Idbaih, A, Delattre, JY, Lathrop, M, Robertson, LB, Houlston, RS, Sanson, M, Simon, M, Hosking, FJ, Marie, Y, Gousias, K, Boisselier, B, Carpentier, C, Schramm, J, Mokhtari, K, Hoang-Xuan, KH, Idbaih, A, Delattre, JY, Lathrop, M, Robertson, LB, Houlston, RS, and Sanson, M
- Published
- 2010
73. Chromosome 1p loss evaluation in anaplastic oligodendrogliomas.
- Author
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Idbaih, A., Kouwenhoven, M., Jeuken, J.W.M., Carpentier, C., Gorlia, T., Kros, J.M., French, P., Teepen, J.L., Delattre, O., Delattre, J.Y., Bent, M. van den, Hoang-Xuan, K., Idbaih, A., Kouwenhoven, M., Jeuken, J.W.M., Carpentier, C., Gorlia, T., Kros, J.M., French, P., Teepen, J.L., Delattre, O., Delattre, J.Y., Bent, M. van den, and Hoang-Xuan, K.
- Abstract
Contains fulltext : 69651.pdf (publisher's version ) (Closed access), The chromosome (chr) 1p deletion is a favorable biomarker in oligodendroglial tumors and is even more powerful a marker when combined with chr 19q loss. As a result, the 1p deletion is taken into account more and more in clinical trials and the management of patients. However, the laboratory technique implemented for detection of this biomarker has been a topic of debate. To illustrate the usefulness of evaluating multiple loci, we here report two anaplastic oligodendrogliomas that were investigated using fluorescent in situ hybridization (FISH) and bacterial artificial chromosome (BAC)-array-based comparative genomic hybridization (aCGH). Indeed, segmental analysis using FISH, limited to chr 1p36 was unable to discriminate between complete and partial deletions of chrs 1p. However, complete and partial deletions of 1p are reported to have distinct clinical outcomes. Our results illustrate that aCGH (or other multiple loci technologies) provide complementary information to single locus technologies such as FISH because multiple loci technologies can evaluate the extent of the chr 1p deletion.
- Published
- 2008
74. Assessing species richness and diversity at the community level : methodological background
- Author
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Houllier, François and Gimaret Carpentier, C.
- Subjects
Méthode statistique ,U10 - Informatique, mathématiques et statistiques ,Inventaire forestier ,F70 - Taxonomie végétale et phytogéographie ,K10 - Production forestière ,Forêt ,Évaluation ,Échantillonnage ,Biodiversité ,Communauté végétale - Abstract
Most difficulties in biodiversity assessment arise from the very fact that it is essentially a matter of measuring a variability and not an average : counting the number of species which are different from each other rather than the average number of stems per ha. As a consequence : the usual sampling strategies which aim at estimating an average and its precision are not necessarily adapted; much more than for other resources, assessing biodiversity is scale- and level-dependent. Another important methodological point for regional studies and across-ecosystems studies is that the assessment of species diversity and richness of ecosystems is the dual viewpoint of the study of the ecological niche and geographic distribution of species. In this context, this lecture reviews the following topics : - General statistical background : sampling design and estimators; accuracy and precision; random, systematic, stratified and cluster sampling. - Assessment of species richness : number of observed species and species list; why the natural estimator obtained as the number of observed species is biased (it always underestimates the true richness); the cumulative species-area and species-individual curves and the correction method designed by Sanders and Hurlbert to compare samples of different size; the relative efficiency of various sampling designs and estimators : random, systematic and stratified sampling, fixed-area vs. fixed-number of individual plots, non parametric estimators. - Assessment of species diversity : diversity as a combination of species richness and evenness and the role of rare species; statistical properties of the usual estimators of Simpson's and Shannon's indexes of diversity : accuracy and precision.
- Published
- 1998
75. The ATLAS semiconductor tracker end-cap module
- Author
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Abdesselam, A., Adkin, P. J., Allport, P. P., Alonso, J., Andricek, L., Anghinolfi, F., Antonov, A. A., Apsimon, R. J., Atkinson, T., Batchelor, L. E., Bates, R. L., Beck, G., Becker, H., Bell, P., Bell, W., Benes, P., Bernabeu, J., Bethke, S., Bizzell, J. P., Blocki, J., Broklova, Z., Broz, J., Bohm, J., Booker, P., Bright, G., Brodbeck, T. J., Bruckman, P., Buttari, C. M., Butterworth, J. M., Campabadal, F., Campbell, D., Carpentier, C., Carroll, J. L., Carter, A. A., Carter, J. R., Casse, G. L., Cermak, P., Chamizo, M., Charlton, D. G., Cheplakov, A., Chesi, E., Chilingarov, A., Chouridou, S., Chren, D., Christinet, A., Chu, M. L., Cindro, V., Clocio, A., Civera, J. V., Clark, A., Colijn, A. P., Cooke, P. A., Costa, M. J., Costanzo, D., Dabrowski, W., Danielsen, K. M., Davies, V. R., Dawson, I., de Jong, P., Dervan, P., Doherty, F., Dolezal, Z., Donega, M., D'Onofrio, M., Dorholt, O., Drasal, Z., Dowell, J. D., Duerdoth, I. P., Duxfield, R., Dwuznik, M., Easton, J. M., Eckert, S., Eklund, L., Escobar, C., Fadeyev, V., Fasching, D., Feld, L., Ferguson, D. P. S., Ferrari, P., Ferrere, D., Fleta, C., Fortin, R., Foster, J. M., Fowler, C., Fox, H., Freestone, J., French, R. S., Fuster, J., Gadomski, S., Gallop, B. J., Garcia, C., Garcia-Navarro, J. E., Gibson, S., Gilchriese, M. G. D., Gonzalez, F., Gonzalez-Sevilla, S., Goodrick, M. J., Gorisek, A., Gornicki, E., Greenall, A., Greenfield, D., Gregory, S., Grigorieva, I. G., Grillo, A. A., Grosse-Knetter, J., Gryska, C., Guipet, A., Haber, C., Hara, K., Hartjes, F. G., Hauff, D., Haywood, S. J., Hegeman, S. J., Heinzinger, K., Hessey, N. P., Heusch, C., Hicheur, A., Hill, J. C., Hodgkinson, M., Hodgson, P., Horazdovsky, T., Hollins, T. I., Hou, L. S., Hou, S., Hughes, G., Huse, T., Ibbotson, M., Iglesias, M., Ikegami, Y., Ilyashenko, I., Issever, C., Jackson, J. N., Jakobs, K., Jared, R. C., Jarron, P., Johansson, P., Jones, R. W. L., Jones, T. J., Joos, D., Joseph, J., Jovanovic, P., Jusko, O., Jusko, V., Kaplon, J., Kazi, S., Ketterer, Ch., Kholodenko, A. G., King, B. T., Kodys, P., Koffeman, E., Kohout, Z., Kohriki, T., Kondo, T., Koperny, S., Koukol, H., Kral, V., Kramberger, G., Kubik, P., Kudlaty, J., Lacasta, C., Lagouri, T., Lee, S. C., Leney, K., Lenz, S., Lester, C. G., Liebicher, K., Limper, M., Lindsay, S., Linhart, V., Llosa, G., Loebinger, F. K., Lozano, M., Ludwig, I., Ludwig, J., Lutz, G., Lys, J., Maassen, M., Macina, D., Macpherson, A., MacWaters, C., Magrath, C. A., Malecki, P., Mandic, I., Mangin-Brinet, M., Marti-Garcia, S., Matheson, J. P., Matson, R. M., McMahon, S. J., McMahon, T. J., Meinhardt, J., Mellado, B., Melone, J. J., Mercer, I. J., Messmer, I., Mikulec, B., Mikuz, M., Minano, M., Mitsouak, V. A., Modesto, P., Moed, S., Mohn, B., Moncrieff, S., Moorhead, G., Morris, F. S., Morris, J., Morrissey, M., Moser, H. G., Moszczynski, A., Muijs, A. J. M., Murray, W. J., Muskett, D., Nacher, J., Nagai, K., Nakano, I., Nickerson, R. B., Nisius, R., Oye, O. K., O'Shea, V., Paganis, E., Parker, M. A., Parzefall, U., Pater, J. R., Peeters, S. J. M., Pellegrini, G., Pelleriti, G., Pernegger, H., Perrin, E., Phillips, P. W., Pilavova, L. V., Poltorak, K., Pospisil, S., Postranecky, M., Pritchard, T., Prokofiev, K., Rafi, J. M., Raine, C., Ratoff, P. N., Reznicek, P., Riadovikov, V. N., Richter, R. H., Robichaud-Veronneau, A., Robinson, D., Rodriguez-Oliete, R., Roe, S., Rudge, A., Runge, K., Saavedra, A., Sadrozinski, H. F. W., Sanchez, F. J., Sandaker, H., Saxon, D. H., Scheirich, D., Schieck, J., Seiden, A., Sfyrla, A., Slavicek, T., Smith, K. M., Smith, N. A., Snow, S. W., Solar, M., Sopko, B., Sopko, V., Sospedra, L., Spencer, E., Stanecka, E., Stapnes, S., Stastny, J., Strachko, V., Stradling, A., Stugu, B., Su, D. S., Sutcliffe, P., Szczygiel, R., Tanaka, R., Taylor, G., Teng, P. K., Terada, S., Thompson, R. J., Titov, M., Toczek, B., Tovey, D. R., Tratzl, G., Troitsky, V. L., Tseng, J., Turala, M., Turner, P. R., Tyndel, M., Ullan, M., Unno, Y., Vickey, T., Van der Kraaij, E., Viehhauser, G., Villani, E. G., Vitek, T., Anh, T. Vu, Vorobiev, A. P., Vossebeld, J. H., Wachler, M., Wallny, R., Ward, C. P., Warren, M. R. M., Webel, M., Weber, M., Weidberg, A. R., Weilhammer, P., Wells, P. S., Wetzel, P., Whitley, M., Wiesmann, M., Wilhelm, I., Willenbrock, M., Wilmut, I., Wilson, J. A., Winton, J., Wolter, M., Wormald, M. P., Wu, S. L., Wu, X., Zhu, H., Bingefors, Nils, Brenner, Richard, Ekelöf, Tord, Abdesselam, A., Adkin, P. J., Allport, P. P., Alonso, J., Andricek, L., Anghinolfi, F., Antonov, A. A., Apsimon, R. J., Atkinson, T., Batchelor, L. E., Bates, R. L., Beck, G., Becker, H., Bell, P., Bell, W., Benes, P., Bernabeu, J., Bethke, S., Bizzell, J. P., Blocki, J., Broklova, Z., Broz, J., Bohm, J., Booker, P., Bright, G., Brodbeck, T. J., Bruckman, P., Buttari, C. M., Butterworth, J. M., Campabadal, F., Campbell, D., Carpentier, C., Carroll, J. L., Carter, A. A., Carter, J. R., Casse, G. L., Cermak, P., Chamizo, M., Charlton, D. G., Cheplakov, A., Chesi, E., Chilingarov, A., Chouridou, S., Chren, D., Christinet, A., Chu, M. L., Cindro, V., Clocio, A., Civera, J. V., Clark, A., Colijn, A. P., Cooke, P. A., Costa, M. J., Costanzo, D., Dabrowski, W., Danielsen, K. M., Davies, V. R., Dawson, I., de Jong, P., Dervan, P., Doherty, F., Dolezal, Z., Donega, M., D'Onofrio, M., Dorholt, O., Drasal, Z., Dowell, J. D., Duerdoth, I. P., Duxfield, R., Dwuznik, M., Easton, J. M., Eckert, S., Eklund, L., Escobar, C., Fadeyev, V., Fasching, D., Feld, L., Ferguson, D. P. S., Ferrari, P., Ferrere, D., Fleta, C., Fortin, R., Foster, J. M., Fowler, C., Fox, H., Freestone, J., French, R. S., Fuster, J., Gadomski, S., Gallop, B. J., Garcia, C., Garcia-Navarro, J. E., Gibson, S., Gilchriese, M. G. D., Gonzalez, F., Gonzalez-Sevilla, S., Goodrick, M. J., Gorisek, A., Gornicki, E., Greenall, A., Greenfield, D., Gregory, S., Grigorieva, I. G., Grillo, A. A., Grosse-Knetter, J., Gryska, C., Guipet, A., Haber, C., Hara, K., Hartjes, F. G., Hauff, D., Haywood, S. J., Hegeman, S. J., Heinzinger, K., Hessey, N. P., Heusch, C., Hicheur, A., Hill, J. C., Hodgkinson, M., Hodgson, P., Horazdovsky, T., Hollins, T. I., Hou, L. S., Hou, S., Hughes, G., Huse, T., Ibbotson, M., Iglesias, M., Ikegami, Y., Ilyashenko, I., Issever, C., Jackson, J. N., Jakobs, K., Jared, R. C., Jarron, P., Johansson, P., Jones, R. W. L., Jones, T. J., Joos, D., Joseph, J., Jovanovic, P., Jusko, O., Jusko, V., Kaplon, J., Kazi, S., Ketterer, Ch., Kholodenko, A. G., King, B. T., Kodys, P., Koffeman, E., Kohout, Z., Kohriki, T., Kondo, T., Koperny, S., Koukol, H., Kral, V., Kramberger, G., Kubik, P., Kudlaty, J., Lacasta, C., Lagouri, T., Lee, S. C., Leney, K., Lenz, S., Lester, C. G., Liebicher, K., Limper, M., Lindsay, S., Linhart, V., Llosa, G., Loebinger, F. K., Lozano, M., Ludwig, I., Ludwig, J., Lutz, G., Lys, J., Maassen, M., Macina, D., Macpherson, A., MacWaters, C., Magrath, C. A., Malecki, P., Mandic, I., Mangin-Brinet, M., Marti-Garcia, S., Matheson, J. P., Matson, R. M., McMahon, S. J., McMahon, T. J., Meinhardt, J., Mellado, B., Melone, J. J., Mercer, I. J., Messmer, I., Mikulec, B., Mikuz, M., Minano, M., Mitsouak, V. A., Modesto, P., Moed, S., Mohn, B., Moncrieff, S., Moorhead, G., Morris, F. S., Morris, J., Morrissey, M., Moser, H. G., Moszczynski, A., Muijs, A. J. M., Murray, W. J., Muskett, D., Nacher, J., Nagai, K., Nakano, I., Nickerson, R. B., Nisius, R., Oye, O. K., O'Shea, V., Paganis, E., Parker, M. A., Parzefall, U., Pater, J. R., Peeters, S. J. M., Pellegrini, G., Pelleriti, G., Pernegger, H., Perrin, E., Phillips, P. W., Pilavova, L. V., Poltorak, K., Pospisil, S., Postranecky, M., Pritchard, T., Prokofiev, K., Rafi, J. M., Raine, C., Ratoff, P. N., Reznicek, P., Riadovikov, V. N., Richter, R. H., Robichaud-Veronneau, A., Robinson, D., Rodriguez-Oliete, R., Roe, S., Rudge, A., Runge, K., Saavedra, A., Sadrozinski, H. F. W., Sanchez, F. J., Sandaker, H., Saxon, D. H., Scheirich, D., Schieck, J., Seiden, A., Sfyrla, A., Slavicek, T., Smith, K. M., Smith, N. A., Snow, S. W., Solar, M., Sopko, B., Sopko, V., Sospedra, L., Spencer, E., Stanecka, E., Stapnes, S., Stastny, J., Strachko, V., Stradling, A., Stugu, B., Su, D. S., Sutcliffe, P., Szczygiel, R., Tanaka, R., Taylor, G., Teng, P. K., Terada, S., Thompson, R. J., Titov, M., Toczek, B., Tovey, D. R., Tratzl, G., Troitsky, V. L., Tseng, J., Turala, M., Turner, P. R., Tyndel, M., Ullan, M., Unno, Y., Vickey, T., Van der Kraaij, E., Viehhauser, G., Villani, E. G., Vitek, T., Anh, T. Vu, Vorobiev, A. P., Vossebeld, J. H., Wachler, M., Wallny, R., Ward, C. P., Warren, M. R. M., Webel, M., Weber, M., Weidberg, A. R., Weilhammer, P., Wells, P. S., Wetzel, P., Whitley, M., Wiesmann, M., Wilhelm, I., Willenbrock, M., Wilmut, I., Wilson, J. A., Winton, J., Wolter, M., Wormald, M. P., Wu, S. L., Wu, X., Zhu, H., Bingefors, Nils, Brenner, Richard, and Ekelöf, Tord
- Abstract
The challenges for the tracking detector systems at the LHC are unprecedented in terms of the number of channels, the required read-out speed and the expected radiation levels. The ATLAS Semiconductor Tracker. (SCT) end-caps have a total of about 3 million electronics channels each reading out every 25 ns into its own on-chip 3.3 mu s buffer. The highest anticipated dose after 10 years operation is 1.4x10(14) cm(-2) in units of 1 MeV neutron equivalent (assuming the damage factors scale with the non-ionising energy loss). The forward tracker has 1976 double-sided modules, mostly of area similar to 70 cm(2), each having 2 x 768 strips read out by six ASICs per side. The requirement to achieve an average perpendicular radiation length of 1.5% X-0, while coping with up to 7 W dissipation per module (after irradiation), leads to stringent constraints on the thermal design. The additional requirement of 1500e(-) equivalent noise charge (ENC) rising to only 1800e(-) ENC after irradiation, provides stringent design constraints on both the high-density Cu/Polyimide flex read-out circuit and the ABCD3TA read-out ASICs. Finally, the accuracy of module assembly must not compromise the 16 mu m (r phi) resolution perpendicular to the strip directions or 580 mu m radial resolution coming from the 40 mrad front-back stereo angle. A total of 2210 modules were built to the tight tolerances and specifications required for the SCT. This was 234 more than the 1976 required and represents a yield of 93%. The component flow was at times tight, but the module production rate of 40-50 per week was maintained despite this. The distributed production was not found to be a major logistical problem and it allowed additional flexibility to take advantage of where the effort was available, including any spare capacity, for building the end-cap modules. The collaboration that produced the ATLAS SCT end-cap modules kept in close contact at all times so that the effects of shortages or stoppages at
- Published
- 2007
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76. Prevalence, clinico-pathological value, and co-occurrence of PDGFRA abnormalities in diffuse gliomas
- Author
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Alentorn, A., primary, Marie, Y., additional, Carpentier, C., additional, Boisselier, B., additional, Giry, M., additional, Labussiere, M., additional, Mokhtari, K., additional, Hoang-Xuan, K., additional, Sanson, M., additional, Delattre, J.-Y., additional, and Idbaih, A., additional
- Published
- 2012
- Full Text
- View/download PDF
77. Mis-splicing of Tau exon 10 in myotonic dystrophy type 1 is reproduced by overexpression of CELF2 but not by MBNL1 silencing
- Author
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Dhaenens, C.M., primary, Tran, H., additional, Frandemiche, M.-L., additional, Carpentier, C., additional, Schraen-Maschke, S., additional, Sistiaga, A., additional, Goicoechea, M., additional, Eddarkaoui, S., additional, Van Brussels, E., additional, Obriot, H., additional, Labudeck, A., additional, Gevaert, M.H., additional, Fernandez-Gomez, F., additional, Charlet-Berguerand, N., additional, Deramecourt, V., additional, Maurage, C.A., additional, Buée, L., additional, de Munain, A. Lopez, additional, Sablonnière, B., additional, Caillet-Boudin, M.L., additional, and Sergeant, N., additional
- Published
- 2011
- Full Text
- View/download PDF
78. FINITE ELEMENT ANALYSIS OF ULTRASONIC PHASED ARRAY INSPECTIONS ON ANISOTROPIC WELDS
- Author
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Harvey, G., primary, Tweedie, A., additional, Carpentier, C., additional, Reynolds, P., additional, Thompson, Donald O., additional, and Chimenti, Dale E., additional
- Published
- 2011
- Full Text
- View/download PDF
79. All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2
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Labussière, M., primary, Idbaih, A., additional, Wang, X.-W., additional, Marie, Y., additional, Boisselier, B., additional, Falet, C., additional, Paris, S., additional, Laffaire, J., additional, Carpentier, C., additional, Crinière, E., additional, Ducray, F., additional, El Hallani, S., additional, Mokhtari, K., additional, Hoang-Xuan, K., additional, Delattre, J.-Y., additional, and Sanson, M., additional
- Published
- 2010
- Full Text
- View/download PDF
80. Mosselen en algen als poortwachters [Thema: Waterproductiebedrijf Heel]
- Author
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Hoogh-Carpentier, C. de, Diepenbeek, P. van, Engels, P., Noij, T., Hoogh-Carpentier, C. de, Diepenbeek, P. van, Engels, P., and Noij, T.
- Abstract
Op drinkwaterproductiebedrijf Heel wordt de kwaliteit van het ingenomen Maaswater bewaakt door een fysisch-chemisch meetprogramma in combinatie met een biologisch early warning system (BEWS). Het BEWS bestaat uit een mosselmonitor en een algentoximeter. Uitleg over de principes en werking van deze monitoren, de gehanteerde criteria voor de keuze van een BEWS (monitoringsstrategie), en de implementatie van beide systemen. Na het vaststellen van de basisinstellingen en condities waarbij de monitor routinematig moet kunnen functioneren is d.m.v. spike-testen de reactie van de monitor op voor het stroomgebied relevante verontreinigingen onderzocht ( vooral stoffen afkomstig van landbouw, verkeer, bedrijfsmatige activiteiten en industrieel afvalwater)
- Published
- 2002
81. Microstructural quantification, modelling and array ultrasonics to improve the inspection of austenitic welds
- Author
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Nageswaran, C, primary, Carpentier, C, additional, and Tse, Y Y, additional
- Published
- 2009
- Full Text
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82. Chromosome 9p and 10q losses predict unfavorable outcome in low-grade gliomas
- Author
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Houillier, C., primary, Mokhtari, K., additional, Carpentier, C., additional, Criniere, E., additional, Marie, Y., additional, Rousseau, A., additional, Kaloshi, G., additional, Dehais, C., additional, Laffaire, J., additional, Laigle-Donadey, F., additional, Hoang-Xuan, K., additional, Sanson, M., additional, and Delattre, J.-Y., additional
- Published
- 2009
- Full Text
- View/download PDF
83. Bevacizumab and irinotecan for recurrent oligodendroglial tumors
- Author
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Taillibert, S., primary, Vincent, L. A., additional, Granger, B., additional, Marie, Y., additional, Carpentier, C., additional, Guillevin, R., additional, Bellanger, A., additional, Psimaras, D., additional, Sanson, M., additional, and Delattre, J., additional
- Published
- 2009
- Full Text
- View/download PDF
84. 217 Imagerie et chirurgie maculaire
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Carpentier, C., primary
- Published
- 2008
- Full Text
- View/download PDF
85. Microtox kan zinvolle aanvulling op monitoring zijn : seminar over het 'integraal meten' van de waterkwaliteit
- Author
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Denneman, W.D., Carpentier, C., Denneman, W.D., and Carpentier, C.
- Abstract
Verslag van een symposium over integrale waterkwaliteitsmonitoring (chemisch, biologisch en toxicologisch) van oppervlakte-, afval- en drinkwater. Speciale aandacht voor het Microtox-OS Test System, waarmee via bioassay de toxiciteit van een waterstroom on-line wordt gemeten, en de HPLC-fingerprint/toxprint, een methode waarbij chemische en toxicologische technieken gelijktijdig worden toegepast
- Published
- 2000
86. Polymorphism in Sp1 recognition site of the EGF receptor gene promoter and risk of glioblastoma
- Author
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Carpentier, C., primary, Laigle-Donadey, F., additional, Marie, Y., additional, Auger, N., additional, Benouaich-Amiel, A., additional, Lejeune, J., additional, Kaloshi, G., additional, Delattre, J. -Y., additional, Thillet, J., additional, and Sanson, M., additional
- Published
- 2006
- Full Text
- View/download PDF
87. TO19 - Réalisation des injections de toxine botulique sous analgésie par MEOPA
- Author
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Marque, P.H., primary, Rives, B., additional, Bourg, V., additional, Carpentier, C., additional, and Suc, A., additional
- Published
- 2005
- Full Text
- View/download PDF
88. TO48 - Mise en place d’un outil d’évaluation de la douleur adapté au sujet âgé non communiquant en unités de soins gériatriques
- Author
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Carles, M., primary, Guillermin, A., additional, Rolland, Y., additional, Cantagrel, N., additional, Suc, A., additional, Carpentier, C., additional, and Vellas, B., additional
- Published
- 2005
- Full Text
- View/download PDF
89. Coral-microbialite reefs in pure carbonate versus mixed carbonate-siliciclastic depositional environments: the example of the Pagny-sur-Meuse section (Upper Jurassic, northeastern France)
- Author
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Olivier, Nicolas, primary, Carpentier, C�dric, additional, Martin-Garin, Bertrand, additional, Lathuili�re, Bernard, additional, Gaillard, Christian, additional, Ferry, Serge, additional, Hantzpergue, Pierre, additional, and Geister, J�rn, additional
- Published
- 2004
- Full Text
- View/download PDF
90. Le MEOPA est-il une alternative a l’anesthésie générale pour les soins dentaires chez l’enfant ?
- Author
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Fabre, S, primary, Vaysse, F, additional, Carpentier, C, additional, Kern, D, additional, and Fourcade, O, additional
- Published
- 2004
- Full Text
- View/download PDF
91. FINITE ELEMENT ANALYSIS OF ULTRASONIC PHASED ARRAY INSPECTIONS ON ANISOTROPIC WELDS.
- Author
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Harvey, G., Tweedie, A., Carpentier, C., and Reynolds, P.
- Subjects
FINITE element method ,ULTRASONIC testing ,ANTENNA arrays ,ANISOTROPY ,ELECTRIC welding ,SIMULATION methods & models ,TIME reversal - Abstract
This paper describes a theoretical investigation into the behaviour of anisotropic welds under phased array inspection procedures using a 128 element linear array. Two advanced inspection techniques are simulated, and their suitability compared. A finite element (FE) model, configured in PZFlex, is used to represent both the variations in crystal orientation found in a typical anisotropic weld, and also the linear array configuration. Firstly, through transmission spectra of the weld are used to determine the optimum operating frequency and configuration of the array in order to detect a 3 mm SDH in the weld. Next, the Full Matrix Capture (FMC) technique is simulated, and an image of the weld constructed using the Total Focussing Method (TFM). This is accomplished by transmitting on each element sequentially, while receiving on the remaining 127 elements. This approach provides spatial averaging over the weld area, reducing the distortion caused by the anisotropic media. Finally, Time Reversal Acoustic (TRA) methods were employed to coherently focus the array at the defect and compensate for the elemental timing variations caused by the complex medium. Results illustrate the potential for inspecting anisotropic welds when using correctly designed arrays and implementing novel inspection procedures. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
92. The End of Helicobacter Pylori As A Hypothetic Cause of Sids
- Author
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Dubos, F, primary, Gottrand, F, additional, Devisme, L, additional, and Carpentier, C, additional
- Published
- 2003
- Full Text
- View/download PDF
93. PHP3: MACRO-ECONOMIC ANALYSIS OF HEROIN MARKETS IN THE EU AND THE IMPACT OF SUBSTITUTION TREATMENT
- Author
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Annemans, LJ, primary, Vanoverbeke, N, additional, Tecco, J, additional, Hariga, F, additional, and Carpentier, C, additional
- Published
- 2001
- Full Text
- View/download PDF
94. Rapid and versatile routine measurements of plankton biovolumes with BACCHUS
- Author
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Carpentier, C, primary
- Published
- 1999
- Full Text
- View/download PDF
95. Reflux gastroœsophagien et troubles de la motricité œsophagienne chez des nourrissons porteurs d'une hyper-réflectivité vagale ayant présenté un malaise grave
- Author
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Michaud, L, primary, Lamblin, MD, additional, Carpentier, C, additional, Engles, MC, additional, Gottrand, F, additional, Piotte, M, additional, Guieu, JD, additional, Lequien, P, additional, and Turck, D, additional
- Published
- 1997
- Full Text
- View/download PDF
96. Hypoparathyroidie et myopathie association fortuite ?
- Author
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Carpentier, C., primary, Pouille, O., additional, Schoepfer, C., additional, Palcoux, J.B., additional, and Malpuech, G., additional
- Published
- 1997
- Full Text
- View/download PDF
97. Modelling of a thermo-viscoelastic coupling for large deformations through finite element analysis
- Author
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Bérardi, G., primary, Jaeger, M., additional, Martin, R., additional, and Carpentier, C., additional
- Published
- 1996
- Full Text
- View/download PDF
98. Hypertonie vagale et hypertonie du sphincter infŕieur de l'œsophage (SIO): au cors des malaises graves du nourrisson: évolution sous diphémanil
- Author
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Michaud, L., primary, Lamblin, M.D., additional, Carpentier, C., additional, Gottrand, F., additional, Ategbo, S., additional, Lequien, P., additional, and Turck, D., additional
- Published
- 1996
- Full Text
- View/download PDF
99. Hypertonie vagale et anomalies de la motricite oesophagienne au cours des malaises graves du nourrisson évolution sous diphémanil
- Author
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Michaud, L, primary, Lamblin, MD, additional, Carpentier, C, additional, Gottrand, F, additional, Lequien, P, additional, and Turck, D, additional
- Published
- 1996
- Full Text
- View/download PDF
100. Analysis of heart rate variability in infants and children
- Author
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Laurent Storme, P.S. Ganga-Zandzou, M.O. Jaffre, Carpentier C, and Lequien P
- Subjects
medicine.medical_specialty ,business.industry ,Internal medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Cardiology ,Heart rate variability ,business - Published
- 1998
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