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324 results on '"Carrabba, Giorgio"'

51. A Deep Learning Model for Preoperative Differentiation of Glioblastoma, Brain Metastasis and Primary Central Nervous System Lymphoma: A Pilot Study

Author

Tariciotti, Leonardo, primary, Caccavella, Valerio M., additional, Fiore, Giorgio, additional, Schisano, Luigi, additional, Carrabba, Giorgio, additional, Borsa, Stefano, additional, Giordano, Martina, additional, Palmisciano, Paolo, additional, Remoli, Giulia, additional, Remore, Luigi Gianmaria, additional, Pluderi, Mauro, additional, Caroli, Manuela, additional, Conte, Giorgio, additional, Triulzi, Fabio, additional, Locatelli, Marco, additional, and Bertani, Giulio, additional

Published
2022
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52. Occipital Intradiploic Pseudomeningocele – A Rare Complication of Pediatric Posterior Cranial Fossa Surgery: Case Report and Review of the Literature

Author

Bonomo, Giulio, primary, Rubiu, Emanuele, additional, Iess, Guglielmo, additional, Bonomo, Roberta, additional, Amato, Alessia, additional, Restelli, Francesco, additional, Falco, Jacopo, additional, Mazzapicchi, Elio, additional, Locatelli, Marco, additional, Rampini, Paolo, additional, and Carrabba, Giorgio G., additional

Published
2022
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55. Does COVID-19 Affect Survival and Functional Outcome in Emergency and Urgent Neurosurgical Procedures? A Single-Center Prospective Experience During the Pandemic

Author

Fiore, Giorgio, primary, Remore, Luigi Gianmaria, additional, Tariciotti, Leonardo, additional, Carrabba, Giorgio Giovanni, additional, Schisano, Luigi, additional, Pluderi, Mauro, additional, Bertani, Giulio Andrea, additional, Borsa, Stefano, additional, and Locatelli, Marco, additional

Published
2021
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57. Diffusion tensor imaging, intraoperative neurophysiological monitoring and small craniotomy: Results in a consecutive series of 103 gliomas.

Author

Carrabba, Giorgio, Fiore, Giorgio, Di Cristofori, Andrea, Bana, Cristina, Borellini, Linda, Zarino, Barbara, Conte, Giorgio, Triulzi, Fabio, Rocca, Alessandra, Giussani, Carlo, Caroli, Manuela, Locatelli, Marco, and Bertani, Giulio

Subjects
DIFFUSION tensor imaging, CRANIOTOMY, NEUROPHYSIOLOGIC monitoring, INTRAOPERATIVE monitoring, GLIOMAS, EVOKED potentials (Electrophysiology), TUMOR surgery
Abstract

Diffusion tensor imaging (DTI) allows visualization of the main white matter tracts while intraoperative neurophysiological monitoring (IONM) represents the gold standard for surgical resection of gliomas. In recent years, the use of small craniotomies has gained popularity thanks to neuronavigation and to the low morbidity rates associated with shorter surgical procedures. The aim of this study was to review a series of patients operated for glioma using DTI, IONM, and tumor-targeted craniotomies. The retrospective analysis included patients with supratentorial glioma who met the following inclusion criteria: preoperative DTI, intraoperative IONM, tumor-targeted craniotomy, pre- and postoperative MRI, and complete clinical charts. The DTI was performed on a 3T scanner. The IONM included electroencephalography (EEG), transcranial (TC) and/or cortical motor-evoked potentials (MEP), electrocorticography (ECoG), and direct electrical stimulation (DES). Outcomes included postoperative neurological deficits, volumetric extent of resection (EOR), and overall survival (OS). One hundred and three patients (61 men, 42 women; mean age 54 ± 14 years) were included and presented the following WHO histologies: 65 grade IV, 19 grade III, and 19 grade II gliomas. After 3 months, only three patients had new neurological deficits. The median postoperative volume was 0cc (IQR 3). The median OS for grade IV gliomas was 15 months, while for low-grade gliomas it was not reached. In our experience, a small craniotomy and a tumor resection supported by IONM and DTI permitted to achieve satisfactory results in terms of neurological outcomes, EOR, and OS for glioma patients. [ABSTRACT FROM AUTHOR]

Published
2022
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59. Insular lobe surgery and cognitive impairment in gliomas operated with intraoperative neurophysiological monitoring

Author

Zarino, B, Sirtori, M, Meschini, T, Bertani, G, Caroli, M, Bana, C, Borellini, L, Locatelli, M, Carrabba, G, Zarino, Barbara, Sirtori, Martina Andrea, Meschini, Tommaso, Bertani, Giulio Andrea, Caroli, Manuela, Bana, Cristina, Borellini, Linda, Locatelli, Marco, Carrabba, Giorgio, Zarino, B, Sirtori, M, Meschini, T, Bertani, G, Caroli, M, Bana, C, Borellini, L, Locatelli, M, Carrabba, G, Zarino, Barbara, Sirtori, Martina Andrea, Meschini, Tommaso, Bertani, Giulio Andrea, Caroli, Manuela, Bana, Cristina, Borellini, Linda, Locatelli, Marco, and Carrabba, Giorgio

Abstract

Background: For a long time, surgery of insular gliomas was considered at high risk for postoperative cognitive deficits, but recent studies highlighted the feasibility of the surgical approach. The aims of our study were to investigate the presence of language impairment before and after surgery and the relationship between language impairment and tumor volume preoperatively and extent of resection (EOR) 3 months after surgery. Methods: Thirty-five patients with insular gliomas underwent an extensive language assessment before and few days after surgery, and after 3 months. Intraoperative neurophysiological monitoring (IOM) and brain mapping with direct electrical stimulation (DES) were used in all the cases; 8 patients underwent awake craniotomy. Statistical analysis was performed on the language tests administered. Results: Patients with pure left insular lesion showed language impairment before and after surgery. Overall, patients with a left lesion showed a drop of performance after surgery followed by a partial recovery. Moreover, when the tumor involved the insula and adjacent networks, we observed a more severe deficit. No correlations were found between tumor volume, EOR, and language impairment. Conclusions: Left insular lobe is an important hub in language networks; its involvement determines pre- and postsurgical deficits, together with the involvement of white matter connections. Tumor volume and EOR are not risk factors per se directly related to language functioning. Surgery of insular gliomas is possible with a pre- and intraoperative extensive study of the patient with IOM and awake surgery, and encouraged by the trend of cognitive recovery highlighted.

Published
2021

61. Tumor-educated platelets and angiogenesis in glioblastoma : another brick in the wall for novel prognostic and targetable biomarkers, changing the vision from a localized tumor to a systemic pathology

Author

Campanella, R, Guarnaccia, L, Cordiglieri, C, Trombetta, E, Caroli, M, Carrabba, G, La Verde, N, Rampini, P, Gaudino, C, Costa, A, Luzzi, S, Mantovani, G, Locatelli, M, Riboni, L, Navone, S, Marfia, G, Campanella, Rolando, Guarnaccia, Laura, Cordiglieri, Chiara, Trombetta, Elena, Caroli, Manuela, Carrabba, Giorgio, La Verde, Nicla, Rampini, Paolo, Gaudino, Chiara, Costa, Antonella, Luzzi, Sabino, Mantovani, Giovanna, Locatelli, Marco, Riboni, Laura, Navone, Stefania Elena, Marfia, Giovanni, Campanella, R, Guarnaccia, L, Cordiglieri, C, Trombetta, E, Caroli, M, Carrabba, G, La Verde, N, Rampini, P, Gaudino, C, Costa, A, Luzzi, S, Mantovani, G, Locatelli, M, Riboni, L, Navone, S, Marfia, G, Campanella, Rolando, Guarnaccia, Laura, Cordiglieri, Chiara, Trombetta, Elena, Caroli, Manuela, Carrabba, Giorgio, La Verde, Nicla, Rampini, Paolo, Gaudino, Chiara, Costa, Antonella, Luzzi, Sabino, Mantovani, Giovanna, Locatelli, Marco, Riboni, Laura, Navone, Stefania Elena, and Marfia, Giovanni

Abstract

Circulating platelets (PLTs) are able to affect glioblastoma (GBM) microenvironment by supplying oncopromoter and pro-angiogenic factors. Among these mediators, sphingosine-1-phophate (S1P) has emerged as a potent bioactive lipid enhancing cell proliferation and survival. Here, we investigated the effect of “tumor education”, characterizing PLTs from GBM patients in terms of activation state, protein content, and pro-angiogenic potential. PLTs from healthy donors (HD-PLTs) and GBM patients (GBM-PLTs) were collected, activated, and analyzed by flow cytometry, immunofluorescence, and Western blotting. To assess the pro-angiogenic contribution of GBM-PLTs, a functional cord formation assay was performed on GBM endothelial cells (GECs) with PLT-releasate. GBM-PLTs expressed higher positivity for P-selectin compared to HD-PLTs, both in basal conditions and after stimulation with adenosine triphosphate (ADP) and thrombin receptor activating peptide (TRAP). PLTs showed higher expression of VEGFR-1, VEGFR-2, VWF, S1P, S1PR1, SphK1, and SPNS. Interestingly, increased concentrations of VEGF and its receptors VEGFR1 and VEGFR2, VWF, and S1P were found in GBM-PLT-releasate with respect to HD-PLTs. Finally, GBM-PLT-releasate showed a pro-angiogenic effect on GECs, increasing the vascular network’s complexity. Overall, our results demonstrated the contribution of PLTs to GBM angiogenesis and aggressiveness, advancing the potential of an anti-PLT therapy and the usefulness of PLT cargo as predictive and monitoring biomarkers.

Published
2020

62. Pre- and Post-Zygotic TP53 De Novo Mutations in SHH-Medulloblastoma

Author

Azzollini, J, Schiavello, E, Buttarelli, F, Clerici, C, Tizzoni, L, Vecchi, G, Capra, F, Pisati, F, Biassoni, V, Runza, L, Carrabba, G, Giangaspero, F, Massimino, M, Pensotti, V, Manoukian, S, Azzollini, Jacopo, Schiavello, Elisabetta, Buttarelli, Francesca Romana, Clerici, Carlo Alfredo, Tizzoni, Laura, Vecchi, Giovanna De, Capra, Fabio, Pisati, Federica, Biassoni, Veronica, Runza, Letterio, Carrabba, Giorgio, Giangaspero, Felice, Massimino, Maura, Pensotti, Valeria, Manoukian, Siranoush, Azzollini, J, Schiavello, E, Buttarelli, F, Clerici, C, Tizzoni, L, Vecchi, G, Capra, F, Pisati, F, Biassoni, V, Runza, L, Carrabba, G, Giangaspero, F, Massimino, M, Pensotti, V, Manoukian, S, Azzollini, Jacopo, Schiavello, Elisabetta, Buttarelli, Francesca Romana, Clerici, Carlo Alfredo, Tizzoni, Laura, Vecchi, Giovanna De, Capra, Fabio, Pisati, Federica, Biassoni, Veronica, Runza, Letterio, Carrabba, Giorgio, Giangaspero, Felice, Massimino, Maura, Pensotti, Valeria, and Manoukian, Siranoush

Abstract

Li-Fraumeni syndrome (LFS) is an autosomal dominant disorder caused by mutations in the TP53 gene, predisposing to a wide spectrum of early-onset cancers, including brain tumors. In medulloblastoma patients, the role of TP53 has been extensively investigated, though the prevalence of de novo mutations has not been addressed. We characterized TP53 mutations in a monocentric cohort of consecutive Sonic Hedgehog (SHH)-activated medulloblastoma patients. Germline testing was offered based on tumor p53 immunostaining positivity. Among 24 patients, three (12.5%) showed tumor p53 overexpression, of whom two consented to undergo germline testing and resulted as carriers of TP53 mutations. In the first case, family history was uneventful and the mutation was not found in either of the parents. The second patient, with a family history suggestive of LFS, unexpectedly resulted as a carrier of the mosaic mutation c.742=/C>T p.(Arg248=/Trp). The allele frequency was 26% in normal tissues and 42–77% in tumor specimens. Loss of heterozygosity (LOH) in the tumor was also confirmed. Notably, the mosaic case has been in complete remission for more than one year, while the first patient, as most TP53-mutated medulloblastoma cases from other cohorts, showed a severe and rapidly progressive disease. Our study reported the first TP53 mosaic mutation in medulloblastoma patients and confirmed the importance of germline testing in p53 overexpressed SHH-medulloblastoma, regardless of family history.

Published
2020

65. Contributors

Author

Adler, John R., primary, Aglio, Linda S., additional, Akalan, Nejat, additional, Albayrak, Serdar Baki, additional, Al-Mefty, Ossama, additional, Alvernia, Jorge E., additional, Baleriaux, Danielle, additional, Baltacioğlu, Feyyaz, additional, Basiouni, Hiriam, additional, Belirgen, Muhittin, additional, Bello, Jacqueline A., additional, Bhaganagare, Amaresh S., additional, Black, Peter M., additional, Börcek, Alp Özgün, additional, Borchers, John, additional, Brada, Michael, additional, Brotchi, Jacques, additional, Bruneau, Michael, additional, Calvocoressi, Lisa, additional, Carrabba, Giorgio, additional, Carroll, Rona S., additional, Claus, Elizabeth B., additional, Collins, V. Peter, additional, Coppens, Jeroen R., additional, Couldwell, William T., additional, Couser, Chris, additional, de Paiva Neto, Manoel A., additional, Desai, Ketan I., additional, Dinçer, Alp, additional, Doglietto, Francesco, additional, Dusick, Joshua R., additional, Erzen, Canan, additional, Fahlbusch, Rudolf, additional, Farinhas, Joaquim M., additional, Fatemi, Nasrin, additional, Fraifeld, Shifra, additional, Gentili, Fred, additional, Gerganov, Venelin M., additional, Goel, Atul, additional, Golby, Alexandra J., additional, Gold, Menachem M., additional, Gormley, William B., additional, Governale, Lance S., additional, Guha, Abhijit, additional, Hara, Wendy, additional, Hasegawa, Toshinori, additional, Hassler, Werner, additional, Hoang, Stanley, additional, Hofmann, Bernd M., additional, Holzemer, Liz L., additional, Hornyak, Mark, additional, Jayne, John A., additional, Kalamarides, Michel, additional, Kano, Hideyuki, additional, Kansu, Tulay, additional, Kawase, Takeshi, additional, Kaya, Dilaver, additional, Kaye, Andrew H., additional, Kelly, Daniel F., additional, Kikinis, Ron, additional, Kiliç, Türker, additional, King, James A.J., additional, Kohan, Saeed, additional, Kondziolka, Douglas, additional, Konukoglu, Ender, additional, Konya, Deniz, additional, Krayenbühl, Niklaus, additional, Kubo, Osami, additional, Laws, Edward R., additional, Li, Gordon, additional, Loeffler, Jay S., additional, Lunsford, L. Dade, additional, Malkasian, Dennis, additional, Martins, Carolina, additional, Mathiesen, Tiit, additional, Minniti, Giuseppe, additional, Mukhopadhyay, Debabrata, additional, Niranjan, Ajay, additional, Norden, Andrew D., additional, Ono, Y., additional, Özduman, Koray, additional, Özek, M. Memet, additional, Özgen, Serdar, additional, Özgen, Tuncalp, additional, Pamir, M. Necmettin, additional, Patil, Chirag G., additional, Peker, Selçuk, additional, Pham, Annette M., additional, Piepmeier, Joseph M., additional, Pohl, Killian M., additional, Radovanovic, Ivan, additional, Ramakrishna, Naren Raj, additional, Rhoton, Albert L., additional, Rosenthal, Guy, additional, Rutka, James T., additional, Rutka, John A., additional, Sadetzki, Siegal, additional, Sakamoto, Gordon T., additional, Sakata, Katsumi, additional, Samii, Madjid, additional, Sav, Aydin, additional, Scheithauer, Bernd, additional, Schick, Uta, additional, Schramm, Johannes, additional, Schweder, Patrick, additional, Seifert, Volker, additional, Seker, Askin, additional, Shifteh, Keivan, additional, Shih, Helen A., additional, Shoshan, Yigal, additional, Simon, Matthias, additional, Simons, Robert L., additional, Sindou, Marc P., additional, Spektor, Sergey, additional, Takakura, K., additional, Tariq, Farzana, additional, Teramoto, A., additional, Umansky, Felix, additional, Us, Onder, additional, Ware, Marcus L., additional, Weber, Damien C., additional, Wen, Patrick Y., additional, Wollmann, Guido, additional, Yamamoto, Isao, additional, Yoshida, Jun, additional, and Zauberman, Jacob, additional

Published
2010
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66. Cervicomedullary Gliomas in Pediatric Age: A Systematic Review of the Literature and Tertiary Care Center Experience.

Author

Trezza, Andrea, de Laurentis, Camilla, Biassoni, Veronica, Carrabba, Giorgio G., Schiavello, Elisabetta, Canonico, Francesco, Remida, Paolo, Moretto, Alessandra, Massimino, Maura, and Giussani, Carlo

Subjects
CENTRAL nervous system tumors, GLIOMAS, TERTIARY care, PEDIATRIC therapy, MOLECULAR diagnosis
Abstract

Introduction: Cervicomedullary gliomas (CMGs) are usually low-grade tumors often found in the pediatric age. Histological findings, treatments, and classification have been much the same for 40 years, although histological and molecular classifications have largely been developed for other pediatric CNS tumors. The management and treatment of pediatric CMG are still conducted by many authors according to their anatomical location and characteristics, independently from histology. Methods: We conducted a literature review in PubMed (Medline) to identify relevant contributions about pediatric CMG published until December 31, 2021. We also analyzed a series of 10 patients with CMG treated from 2006 to 2021 at IRCCS Istituto Nazionale dei Tumori. The aim of the present review was to see whether and how the diagnosis, treatment, and classification of CMGs in children have developed over time, especially in the context of molecular advancements, and to analyze our single-center experience in the last 15 years. Results: Thirty articles have been included in the review. Articles have been divided into two historical periods (1981–2000 and 2001–2021) and data from different series were analyzed to see how much the management and treatment of pediatric CMG have changed during years. Analysis of our series of 10 patients affected by CMG was also performed to compare it with the literature. Discussion: Management and classification of CMG in children have not dramatically changed during years. However, new insight from molecular diagnostics and target therapies and the development of radiological, neurophysiological, and radiotherapy techniques have updated treatment modalities in the last 20 years. Treatment modalities and their innovations have been reviewed and discussed. Further studies are needed to standardize and customize treatment protocols for these tumors. [ABSTRACT FROM AUTHOR]

Published
2022
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71. Pre- and Post-Zygotic TP53 De Novo Mutations in SHH-Medulloblastoma

Author

Azzollini, Jacopo, primary, Schiavello, Elisabetta, additional, Buttarelli, Francesca Romana, additional, Clerici, Carlo Alfredo, additional, Tizzoni, Laura, additional, Vecchi, Giovanna De, additional, Capra, Fabio, additional, Pisati, Federica, additional, Biassoni, Veronica, additional, Runza, Letterio, additional, Carrabba, Giorgio, additional, Giangaspero, Felice, additional, Massimino, Maura, additional, Pensotti, Valeria, additional, and Manoukian, Siranoush, additional

Published
2020
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73. microRNAs and Markers of Neutrophil Activation as Predictors of Early Incidental Post-Surgical Pulmonary Embolism in Patients with Intracranial Tumors

Author

Oto, Julia, primary, Plana, Emma, additional, Solmoirago, María José, additional, Fernández-Pardo, Álvaro, additional, Hervás, David, additional, Cana, Fernando, additional, España, Francisco, additional, Artoni, Andrea, additional, Bucciarelli, Paolo, additional, Carrabba, Giorgio, additional, Navarro, Silvia, additional, Merati, Giuliana, additional, and Medina, Pilar, additional

Published
2020
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75. Tumor-Educated Platelets and Angiogenesis in Glioblastoma: Another Brick in the Wall for Novel Prognostic and Targetable Biomarkers, Changing the Vision from a Localized Tumor to a Systemic Pathology

Author

Campanella, Rolando, primary, Guarnaccia, Laura, additional, Cordiglieri, Chiara, additional, Trombetta, Elena, additional, Caroli, Manuela, additional, Carrabba, Giorgio, additional, La Verde, Nicla, additional, Rampini, Paolo, additional, Gaudino, Chiara, additional, Costa, Antonella, additional, Luzzi, Sabino, additional, Mantovani, Giovanna, additional, Locatelli, Marco, additional, Riboni, Laura, additional, Navone, Stefania Elena, additional, and Marfia, Giovanni, additional

Published
2020
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78. Cushing’s disease: a prospective case-control study of health-related quality of life and cognitive status before and after surgery

Author

Zarino, Barbara, primary, Verrua, Elisa, additional, Ferrante, Emanuele, additional, Sala, Elisa, additional, Carosi, Giulia, additional, Giavoli, Claudia, additional, Serban, Andreea L., additional, Del Sindaco, Giulia, additional, Sirtori, Martina A., additional, Bertani, Giulio A., additional, Rampini, Paolo, additional, Carrabba, Giorgio G., additional, Arosio, Maura, additional, Spada, Anna, additional, Locatelli, Marco, additional, and Mantovani, Giovanna, additional

Published
2019
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79. Minimally invasive fetal surgery for myelomeningocele: preliminary report from a single center

Author

Carrabba, Giorgio, primary, Macchini, Francesco, additional, Fabietti, Isabella, additional, Schisano, Luigi, additional, Meccariello, Giulia, additional, Campanella, Rolando, additional, Bertani, Giulio, additional, Locatelli, Marco, additional, Boito, Simona, additional, Porro, Giuliana A., additional, Gabetta, Lorenzo, additional, Picciolini, Odoardo, additional, Cinnante, Claudia, additional, Triulzi, Fabio, additional, Ciralli, Fabrizio, additional, Mosca, Fabio, additional, Lapa, Denise A., additional, Leva, Ernesto, additional, Rampini, Paolo, additional, and Persico, Nicola, additional

Published
2019
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80. Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease?

Author

Arighi, Andrea, primary, Di Cristofori, Andrea, additional, Fenoglio, Chiara, additional, Borsa, Stefano, additional, D’Anca, Marianna, additional, Fumagalli, Giorgio Giulio, additional, Locatelli, Marco, additional, Carrabba, Giorgio, additional, Pietroboni, Anna Margherita, additional, Ghezzi, Laura, additional, Carandini, Tiziana, additional, Colombi, Annalisa, additional, Scarioni, Marta, additional, De Riz, Milena Alessandra, additional, Serpente, Maria, additional, Rampini, Paolo Maria, additional, Scarpini, Elio, additional, and Galimberti, Daniela, additional

Published
2019
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81. Therapeutic effect of Anakinra in the relapsing chronic phase of febrile infection–related epilepsy syndrome

Author

Dilena, Robertino, primary, Mauri, Eleonora, additional, Aronica, Eleonora, additional, Bernasconi, Pia, additional, Bana, Cristina, additional, Cappelletti, Cristina, additional, Carrabba, Giorgio, additional, Ferrero, Stefano, additional, Giorda, Roberto, additional, Guez, Sophie, additional, Scalia Catenacci, Stefano, additional, Triulzi, Fabio, additional, Barbieri, Sergio, additional, Calderini, Edoardo, additional, and Vezzani, Annamaria, additional

Published
2019
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84. Rathke's cleft cyst associated with pituitary granulomatosis with polyangiitis : an unusual combination of hypothalamus-pituitary region pathologies

Author

Draghi, R, Mantovani, G, Runza, L, Carrabba, G, Fusco, N, Rampini, P, Costa, A, Locatelli, M, Draghi, Riccardo, Mantovani, Giovanna, Runza, Letterio, Carrabba, Giorgio, Fusco, Nicola, Rampini, Paolo, Costa, Antonella, Locatelli, Marco, Draghi, R, Mantovani, G, Runza, L, Carrabba, G, Fusco, N, Rampini, P, Costa, A, Locatelli, M, Draghi, Riccardo, Mantovani, Giovanna, Runza, Letterio, Carrabba, Giorgio, Fusco, Nicola, Rampini, Paolo, Costa, Antonella, and Locatelli, Marco

Abstract

The authors present an unusual case of a patient suffering from visual deficit due to pituitary granulomatosis with polyangiitis (GPA) associated with Rathke's cleft cyst (RCC). The patient was referred to our Neurosurgery Department presenting right eye amaurosis, third cranial nerve palsy, and left temporal hemianopsia. Magnetic resonance imaging documented a sellar or suprasellar lesion with solid and cystic components. The dura mater of the skull base was also strongly enhanced. The patient underwent surgery. Histologic examination revealed RCC associated with pituitary GPA. To our knowledge, this is the first reported case of concomitant pituitary GPA and RCC. Pituitary involvement in GPA is rare, usually diagnosed in hormonal dysfunctions. The patient in case first presented optic chiasm compression, probably due to inflammation of both the pituitary gland and the previously asymptomatic RCC. We focus on the symptoms that led us to diagnose GPA pituitary involvement and on the peculiar and unusual Magnetic resonance imaging of the case presented.

Published
2018

85. Surgery in elderly patients with intracranial meningioma : neuropsychological functioning during a long term follow-up

Author

Di Cristofori, A, Zarino, B, Bertani, G, Locatelli, M, Rampini, P, Carrabba, G, Caroli, M, Di Cristofori, Andrea, Zarino, Barbara, Bertani, Giulio, Locatelli, Marco, Rampini, Paolo, Carrabba, Giorgio, Caroli, Manuela, Di Cristofori, A, Zarino, B, Bertani, G, Locatelli, M, Rampini, P, Carrabba, G, Caroli, M, Di Cristofori, Andrea, Zarino, Barbara, Bertani, Giulio, Locatelli, Marco, Rampini, Paolo, Carrabba, Giorgio, and Caroli, Manuela

Abstract

Surgical treatment of elderly patients with meningioma is has proved to be safe, especially when patients are selected using dedicated surgical scores. These scores take into account tumor size, edema, location and patient’s co-morbidities. Neuropsychological functioning (NPF) of this kind of patients has been poorly studied in literature and it is not taken into account by these scores. Aim of our study was to describe the long-term outcome in terms of NPF of elderly patients undergoing surgery. Patients older than 70 years of age affected by intracranial meningioma and selected with the Clinical-Radiological Grading Score were included in our study. Neuropsychological testing was performed using a dedicated battery of tests before surgery, 3 and 12 months after surgery. Clinical, neurological and radiological outcomes were studied as well. Forty-one patients with a median age of 74 years were included in this study. Preoperatively only 1/41 patients showed a normal NPF with all tests scoring normally. Four out of 39 patients showed a complete neuropsychological recovery after 3 months; while 10/37 patients had a complete recovery after 12 months. NPF showed a trend of progressive improvement after surgery. Our study is the first experience reported in literature describing a long term follow-up in elderly patients after surgery for intracranial meningioma. In our series, surgery determined an improvement of NPF over time; especially with a low complication rate related to the selection of patients obtained through the CRGS. Further studies need to be performed in order to understand how brain edema, tumor size, volume and tumor location affect NPF in both short and long term.

Published
2018

89. Globus pallidus internus deep brain stimulation in PINK-1 related Parkinson's disease: A case report

Author

Borellini, L, Cogiamanian, F, Carrabba, G, Locatelli, M, Rampini, P, Di Fonzo, A, Bana, C, Barbieri, S, Ardolino, G, Borellini, Linda, Cogiamanian, Filippo, Carrabba, Giorgio, Locatelli, Marco, Rampini, Paolo, Di Fonzo, Alessio, Bana, Cristina, Barbieri, Sergio, Ardolino, Gianluca, Borellini, L, Cogiamanian, F, Carrabba, G, Locatelli, M, Rampini, P, Di Fonzo, A, Bana, C, Barbieri, S, Ardolino, G, Borellini, Linda, Cogiamanian, Filippo, Carrabba, Giorgio, Locatelli, Marco, Rampini, Paolo, Di Fonzo, Alessio, Bana, Cristina, Barbieri, Sergio, and Ardolino, Gianluca

Published
2017

92. Diabetic ketoacidosis with central nervous system involvement: Conventional and advanced magnetic resonance neuroimaging findings

Author

Caschera, Luca, Fiore, Giorgio, Nava, Simone, Criscuolo, Stefania, Lo Russo, Francesco M, Casale, Silvia, Conte, Giorgio, Platania, Giulia, Costa, Antonella, Carrabba, Giorgio, Locatelli, Marco, and Triulzi, Fabio Maria

Abstract

Diabetic ketoacidosis (DKA) is a serious complication in children with diabetes mellitus type 1 (DM1). In rare and severe cases DKA may be complicated by cerebral edema, central brain herniation and cerebral infarctions. We present the magnetic resonance imaging findings in a child with DKA and central nervous system involvement; diffusion tensor imaging (DTI) and functional MRI (fMRI) were performed to assess the white matter integrity of sensory pathways and cortical sensory processing. Conventional imaging showed bilateral uncal herniation, effacement of the perimesencephalic cisterns, wide ischemic lesions in the posterior cerebral artery (PCA) territories, sagging brainstem and Duret’s hemorrhage consistent with signs of central brain herniation and intracranial hypertension. Advanced MRI showed a possible left-sided cortical reorganization for sensory function, with underlying left cortico-talamic and cortico-spinal pathways less severely impaired. Knowledge of the full framework in these conditions is of vital importance for timely patient management; advanced neuroimaging techniques may be considered as prognostic indicators in those cases with extensive involvement of eloquent brain areas.

Published
2024
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97. Bilateral Parkinsonism: when to image?

Author

Levi, Vincenzo, primary, Bertani, Giulio Andrea, additional, Carrabba, Giorgio, additional, Locatelli, Marco, additional, Cogiamanian, Filippo, additional, and Rampini, Paolo, additional

Published
2015
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98. Analysis of factors influencing the access to concomitant chemo-radiotherapy in elderly patients with high grade gliomas: role of MMSE, age and tumor volume.

Author

Cristofori, Andrea, Zarino, Barbara, Fanizzi, Claudia, Fornara, Giorgia, Bertani, Giulio, Rampini, Paolo, Carrabba, Giorgio, and Caroli, Manuela

Abstract

High grade gliomas (HGG) are tumors with a rapidly progressive course and the standard of care consists of surgery and chemo-radiotherapy. Elderly patients with HGG usually have a worse prognosis due to their comorbidities and difficulties in accessing or completing adjuvant treatments. The purpose of our study was to assess the influence of pre-operative factors (MMSE, age, sex, KPS, tumor volume) on the post-operative access to chemo-radiotherapy in the elderly population. In addition, the influence of the access to adjuvant therapies on overall survival (OS) was assessed. We retrospectively reviewed our consecutive case series of 117 elderly patients (≥65 years) with HGG treated in our Institution. All the clinical records regarding age, sex, tumor location, MMSE, KPS, access to adjuvant treatments and OS were analyzed. 72 males and 45 females with a median age of 71 years were analyzed. Adjuvant therapies were considered; concomitant chemo-radiotherapy with standard radiotherapy or hypofractionated radiation regimen. 84 patients had access to adjuvant therapies. Access to therapies was associated with a median age of 71(range 66-80) years, a median MMSE of 26(range 5-30), and a median tumor volume of 24 cm(range 1-140). The median OS was 13 months for patients who had access to adjuvant therapies and 5 months for patients who did not. In the elderly patients with HGG, the MMSE, age and tumor volume were predictive of post-surgery access to adjuvant treatments. OS was significantly longer in elderly patients with HGG who had access to post-surgery chemo-radiotherapy. [ABSTRACT FROM AUTHOR]

Published
2017
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