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61. Irish Society of Gastroenterology — Winter Meeting Held at Freeman Auditorium, Mater Misericordiae Hospital, Dublin on Friday, 20th and Saturday, 21st November, 1987

Author

Brown, J. S., Humphreys, W. W., Parks, T. G., Dolan, C., O’Farrelly, C., Weiser, H., Whelan, A., Weir, D. G., Feighery, C., Mackle, E. J., Parks, T. G., Pender, D., Moghissi, K., Geraghty, J. G., Anderson, W. J., Carter, D. C., Cuddihy, A., Jenkins, D., Whelton, M. J., Gilligan, D., Cafferkey, M., Keane, C., O’Morain, C., MacMathuna, P., O’Connor, M. K., O’Connor, M. P., Freyne, P., Keeling, P. W. N., Deasy, J. M., Lavelle, J. P., Clery, A. P., Mackle, E. J., Sawhney, B. B., Mills, J. O. M., Parks, T. G., O’Connor, H. J., Ellis, W. R., Manning, A. P., Lintott, D. L., McMahon, M. J., Axon, A. T. B., Stuart, R., Byrne, P., Keeling, P., Connolly, J., Keane, R. M., Hennessy, T. P. J., Courtney, M. G., McDonald, G. S. A., Hourihane, D. O’B., Weir, D. G., McGibney, Carol, Darzi, A., Monson, J. R. T., Morrison, P., Tanner, W. A., Keane, F. B., Tobin, A., Gilligan, D., Hutchinson, L., Casey, E., McKenna, D., Keane, C. T., Sweeney, E. A., O’Morain, C. A., MacMathuna, P., Foley, B., O’Reilly, T., Chua, A., Feely, J., Keeling, P. W. N., Kelly, C. P., Dolan, C., Feighery, C., Weir, D. G., Darzi, A., Monson, J. R. T., Kay, E., Hurley, C. D., Tanner, W. A., Keane, F. B. V., Deasy, J. M., Carr, J., Clery, A. P., O’Donoghue, D. P., Duffy, M. J., Afdhal, N. H., Creagh, T., Broe, P., Bouchier-Hayes, D., Moran, B. J., Busch, I., Singleton, J. McL, Johnston, P., O’Brien, M., Dervan, P., Crowe, J., Lennon, J., Carney, D. N., Bourke, S., Murphy, B., Maher, K., Stafford, F., O’Morain, C., Daly, C. A., Gorey, T. F., Lavelle, J., Coakley, J. B., Bouchier-Hayes, D., Peng, S. Y., Parks, T. G., Maxwell, W. J., Keating, J., Hogan, F. P., McDonald, G. S. A., Keeling, P. W. N., Coyle, D., Gorey, T. F., Leahy, A. L., Fitzpatrick, P., Bouchier-Hayes, D., O’Donoghue, D. P., Duffy, M. J., Afdhal, N. H., Waldron, D. J., Gill, R. C., Bowes, K. L., Gallagher, R. B., Cervi, P., Dolan, C., Kelly, J., Weir, D. G., Feighery, C., Lavelle, E. M., Stevens, F. M., Duffy, B. S., Coghlan, J. G., Gilligan, D., Humphries, H., McKenna, D., Sweeney, E., Keane, C., O’Morain, C., Murray, D., O’Mahony, S., Buchanan, K., and Whelton, M.

Published
1988
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65. Cell cycle arrest and induction of apoptosis in pancreatic cancer cells exposed to eicosapentaenoic acid in vitro

Author

Lai, P B, Ross, J A, Fearon, K C, Anderson, J D, and Carter, D C

Subjects
endocrine system diseases
Abstract

Eicosapentaenoic acid (EPA) has been shown to have an inhibitory effect on the growth of several pancreatic cancer cell lines in vitro. This study investigates the mechanism of growth inhibition and cytotoxicity of EPA on the pancreatic cancer cell line MIA PaCa-2. Cells were analysed for cell count, viability, cell cycle distribution and ultrastructural changes. There was a time- and dose-dependent decrease in cell count and viability in cultures of pancreatic cancer cells supplemented with EPA. Flow cytometric DNA analysis of MIA PaCa-2 cells incubated with EPA demonstrated the presence of sub G1 populations corresponding to the presence of apoptotic cells and the blockade of cell cycle progression in S-phase and G2/M-phase. The presence of apoptosis in EPA-supplemented cultures was further confirmed by DNA fragmentation and ultrastructural changes associated with apoptosis. Therefore, we conclude that EPA mediates its effect on the pancreatic cancer cell line MIA PaCa-2, at least in part, via cell cycle arrest and the induction of apoptosis.

Published
1996

67. Effect of eicosapentaenoic acid and other fatty acids on the growth in vitro of human pancreatic cancer cell lines

Author

Falconer, J S, Ross, J A, Fearon, K C, Hawkins, R A, O'Riordain, M G, and Carter, D C

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

A number of polyunsaturated fatty acids have been shown to inhibit the growth of malignant cells in vitro. To investigate whether fatty acids modify the growth of human pancreatic cancer, lauric, stearic, palmitic, oleic, linoleic, alpha-linolenic, gamma-linolenic, arachidonic, docosahexaenoic and eicosapentaenoic (EPA) acids were each incubated with the cells lines MIA PaCa-2, PANC-1 and CFPAC at concentrations ranging from 1.25 microM to 50 microM and the effect of each fatty acid on cell growth was examined. All the polyunsaturated fatty acids tested had an inhibitory effect, with EPA being the most potent (ID50 2.5-5 microM). Monounsaturated or saturated fatty acids were not inhibitory. The action of EPA could be reversed with the anti-oxidant vitamin E acetate or with oleic acid. The cyclo-oxygenase inhibitors indomethacin and piroxicam had no effect on the action of EPA. The action of EPA appeared to be associated with the generation of lipid peroxides, although the level of lipid peroxidation did not always appear to correlate directly with the extent of cell death. The ability of certain fatty acids to inhibit significantly the growth of three human pancreatic cancer cell lines in vitro at concentrations which could be achieved in vivo suggests that administration of such fatty acids may be of therapeutic benefit in patients with pancreatic cancer.

Published
1994

69. Erosive Gastritis and Portal Hypertension

Author

Geraghty, J. G., Angerson, W. J., and Carter, D. C.

Subjects
Article Subject
Abstract

There is conflicting evidence concerning the effects of portal hypertension on the gastric mucosa. This paper summarises the histological and haemodynamic alterations which are present in both human and experimental portal hypertension. Despite the fact that histological studies suggests that the gastric mucosa is an oedematous plethoric structure in portal hypertension, haemodynamic studies show that gastric mucosal blood glow is at least maintained if not increased in portal hypertension. The term “active” rather than “passive” congestion is a more appropriate description of the basic change present in the gastric mucosa in portal hypertension.

Published
1992
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70. A Comparison of Sms 201-995 and Oesophageal Tamponade in the Control of Acute Variceal Haemorrhage

Author

Mckee, Ruth F., Garden, O. J., Anderson, J. R., and Carter, D. C.

Subjects
Article Subject
Abstract

Forty endoscopically proven active variceal bleeds were entered in a prospective trial comparing oesophageal tamponade with SMS 201-995 infusion.Oesophageal tamponade controlled 19 of 20 bleeds over the first four hours and 14 of 18 bleeds over 48 hours. SMS 201-995 infusion controlled 18 of 20 bleeds over the first four hours and 10 of 20 bleeds over 48 hours (p = 0.15). No significant differences between the groups were seen in time to control of bleeding, amount of blood transfused or number of patients crossed over to the opposite treatment. Complications in the oesophageal tamponade group were discomfort due to the tube (17 patients) and chest infection (10 patients), while in the SMS 201-995 group 7 chest infections and one episode of hyperglycaemia occurred, with no symptomatic complaints. The patient survived the admission in 15 of the oesophageal tamponade bleeds and all of the SMS 201-995 bleeds (p = 0.047).An intravenous infusion of SMS 201-995 appears to have comparable efficacy to oesophageal tamponade in variceal bleeding.

Published
1992
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91. Irish thoracic society

Author

Chan, K. H., primary, Singh, H. P., additional, Aherne, T., additional, Carabine, U., additional, Gilliland, H., additional, Johnston, J. R., additional, Lowry, K. G., additional, McGuigan, J., additional, Cosgrove, J., additional, Veerasingham, D., additional, McCarthy, J., additional, Hurley, J., additional, Wood, A. E., additional, Gilliland, R., additional, McGuigan, J. A., additional, McManus, K. G., additional, Wilkinson, P., additional, Johnston, L. C., additional, MacMahon, J., additional, Wilson, D., additional, Austin, C., additional, Anikin, V., additional, McManus, K., additional, Gibbons, J. R. P., additional, Sharkey, R., additional, Long, M., additional, Maree, A., additional, O’Neill, S., additional, Maguire, C. P., additional, Hayes, J. P., additional, Masterson, J., additional, Fitzgerald, M. X., additional, Hayes, M., additional, Quigley, C., additional, Mofidi, A., additional, Mofidi, R., additional, O’Neill, M., additional, Watson, J. B. G., additional, O’Halloran, E. T., additional, Shortt, C., additional, Taylor, M., additional, Holland, C., additional, O’Lorcain, P., additional, Pathmakanthan, S., additional, Sreenan, S., additional, Power, C. K., additional, Poulter, L. W., additional, Burke, C. M., additional, Reilly, D., additional, Doyle, S., additional, Power, C., additional, Goggin, A., additional, Debenham, P., additional, Southey, A., additional, O’Connor, C. M., additional, Bourke, W. J., additional, McDonnell, T. J., additional, Buck, J. B., additional, Magee, T. R. A., additional, Lowry, R. C., additional, Graham, A. N. J., additional, Owens, W. A., additional, Kelly, S. B., additional, Costelloe, R. W., additional, Ryan, J., additional, Collins, J., additional, Guerin, D., additional, Rooney, D., additional, Long, E., additional, O’Donnell, M., additional, Cotter, T. P., additional, Bredin, C. P., additional, Buick, J. B., additional, MacMahon, J. J., additional, Finlay, G., additional, Concannon, D., additional, Reid, P. T., additional, Alderdice, J., additional, Carson, J., additional, Sinnamon, D. G., additional, Murphy, S., additional, Scott, T., additional, Keane, C. T., additional, Walsh, J. B., additional, Coakley, D., additional, McKeown, D., additional, Kelly, P., additional, Clancy, L., additional, Kiely, J. L., additional, Cryan, B., additional, Killeen, P., additional, Farrell, S., additional, O’Riordan, D. M., additional, Sheehan, S., additional, Curtain, J., additional, Hogan, J., additional, Malone, A., additional, Ahmed, S., additional, Murphy, M., additional, Fennell, W., additional, Keohane, C., additional, Gleeson, C. M., additional, Ritchie, A. J., additional, Russell, S. E. H., additional, Molloy, E., additional, Keane, M., additional, Coakley, R., additional, Costello, R., additional, Condron, C., additional, Watson, R. G. W., additional, Kelly, C., additional, Redmond, H., additional, Watson, W., additional, Burke, P., additional, Bouchier-Hayes, D., additional, Donnelly, S. C., additional, Haslett, C., additional, Dransfield, I., additional, Robertson, C. E., additional, Carter, D. C., additional, Ross, J. A., additional, Grant, I. S., additional, Tedder, T. F., additional, Heaney, L. G., additional, Cross, L. J. M., additional, Stanford, C. F., additional, Ennis, Madeleine, additional, Gergely, L., additional, Deng, N., additional, Rose, R. M., additional, Hennessy, T., additional, Hickey, L., additional, Thornton, L., additional, Collum, C., additional, Durity, M., additional, Power, J., additional, Johnson, H., additional, Lee, B., additional, Doherty, E., additional, Kelly, E., additional, McDonnell, T., additional, Varghese, G., additional, Gibbons, J., additional, Gower, N. H., additional, and Rudd, R. M., additional

Published
1994
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