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53. Eosinopenia as Predictor of Poor Outcome in Hospitalized COVID-19 Adult Patients from Waves 1 and 2 of 2020 Pandemic

Author

Raphael Cauchois, Lea Pietri, Jean-Baptiste Dalmas, Marie Koubi, Thibaut Capron, Nadim Cassir, Nicola Potere, Ildo Polidoro, Rodolphe Jean, Pierre-André Jarrot, Baptiste Andre, Veronique Veit, Julien Carvelli, Vanessa Pauly, Pascal Chanez, Laurent Papazian, and Gilles Kaplanski

Subjects
eosinopenia, COVID-19, prognosis, biomarker, Biology (General), QH301-705.5
Abstract

During SARS-CoV-2 infection, eosinopenia may reflect a hyperactive immune response. In this study of hospitalized COVID-19 patients, we aimed to better understand the prognostic value of severe eosinopenia (absolute eosinophil count = 0 G/L) and decipher its underlying mechanisms. We retrospectively analyzed the records of COVID-19 patients hospitalized from March to June 2020 in three university hospitals in Marseille, France. We assessed the association between severe eosinopenia and a composite poor outcome in these patients, including the need for oxygen supplementation at >6 L/min, ICU admission, and in-hospital death. Among the 551 COVID-19 patients included in this study, severe eosinopenia was found in 228 (51%) of them on admission to hospital and was associated with a composite poor outcome using multivariate analysis (OR = 2.58; CI95 [1.77–3.75]; p < 0.0001). We found a significant association between the presence of severe eosinopenia on admission and the elevation in C-reactive protein, ferritin, IP-10, and suPAR. The histological findings in a series of 37 autopsies from patients who died from severe COVID-19 and presented with severe eosinopenia showed no pulmonary eosinophil trapping. Severe eosinopenia can be a reliable biomarker associated with a composite poor outcome in hospitalized COVID-19 adult patients. It may reflect the magnitude of immune hyperactivation during severe-to-critical COVID-19.

Published
2022
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60. Wharton’s jelly mesenchymal stromal cells inhibit T-cell proliferation by synergistic IDO and mitochondrial transfer mechanisms

Author

Pochon, Cécile, primary, Perouf, Romain, additional, Bertrand, Allan, additional, Notarantonio, Anne-Béatrice, additional, Charif, Naceur, additional, Bittencourt, M. De Carvalho, additional, Fouquet, Guillemette, additional, Cauchois, Ghislaine, additional, Voisin, Charlotte, additional, Bensoussan, Danièle, additional, Emond, Patrick, additional, Sartelet, Hervé, additional, Moulin, David, additional, de Isla, Natalia, additional, D'Aveni, Maud, additional, and Rubio, Marie-Thérèse, additional

Published
2023
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67. Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation

Author

Léonore Avercenc-Léger, Philippe Guerci, Jean-Marc Virion, Ghislaine Cauchois, Sébastien Hupont, Rachid Rahouadj, Jacques Magdalou, Jean-François Stoltz, Danièle Bensoussan, Céline Huselstein, and Loïc Reppel

Subjects
Chondrogenic differentiation, Mesenchymal stromal cells, Obstetric factors, Proliferation, Umbilical cord, Wharton’s jelly, Medicine (General), R5-920, Biochemistry, QD415-436
Abstract

Abstract Background The umbilical cord is becoming a notable alternative to bone marrow (BM) as a source of mesenchymal stromal cells (MSC). Although age-dependent variations in BM-MSC are well described, less data are available for MSC isolated from Wharton’s jelly (WJ-MSC). We initiated a study to identify whether obstetric factors influenced MSC properties. We aimed to evaluate the correlation between a large number of obstetric factors collected during pregnancy and until peripartum (related to the mother, the labor and delivery, and the newborn) with WJ-MSC proliferation and chondrogenic differentiation parameters. Methods Correlations were made between 27 obstetric factors and 8 biological indicators including doubling time at passage (P)1 and P2, the percentage of proteoglycans and collagens, and the relative transcriptional expression of Sox-9, aggrecans, and total type 2 collagen (Coll2T). Results Amongst the obstetric factors considered, birth weight, the number of amenorrhea weeks, placental weight, normal pregnancy, and the absence of preeclampsia were identified as relevant factors for cell expansion, using multivariate linear regression analysis. Since all the above parameters are related to term, we concluded that WJ-MSC from healthy, full-term infants exhibit greater proliferation capacity. As for chondrogenesis, we also observed that obstetric factors influencing proliferation seemed beneficial, with no negative impact on MSC differentiation. Conclusions Awareness of obstetric factors influencing the proliferation and/or differentiation of WJ-MSC will make it possible to define criteria for collecting optimal umbilical cords with the aim of decreasing the variability of WJ-MSC batches produced for clinical use in cell and tissue engineering.

Published
2017
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68. Neutron irradiation and electrical characterisation of the first 8” silicon pad sensor prototypes for the CMS calorimeter endcap upgrade

Author

Acar, B., primary, Adamov, G., additional, Adloff, C., additional, Afanasiev, S., additional, Akchurin, N., additional, Akgün, B., additional, Alhusseini, M., additional, Alison, J., additional, Figueiredo de sa Sousa de Almeida, J.P., additional, Dias de Almeida, P.G., additional, Alpana, A., additional, Alyari, M., additional, Andreev, I., additional, Aras, U., additional, Aspell, P., additional, Atakisi, I.O., additional, Bach, O., additional, Baden, A., additional, Bakas, G., additional, Bakshi, A., additional, Banerjee, S., additional, DeBarbaro, P., additional, Bargassa, P., additional, Barney, D., additional, Beaudette, F., additional, Beaujean, F., additional, Becheva, E., additional, Becker, A., additional, Behera, P., additional, Belloni, A., additional, Bergauer, T., additional, El Berni, M., additional, Besancon, M., additional, Bhattacharya, S., additional, Bhowmik, D., additional, Bilki, B., additional, Blekman, F., additional, Bloch, P., additional, Bodek, A., additional, Bonanomi, M., additional, Bonnemaison, A., additional, Bonomally, S., additional, Borg, J., additional, Bouyjou, F., additional, Bower, N., additional, Braga, D., additional, Brennan, L., additional, Brondolin, E., additional, Bryant, P., additional, Butler-Nalin, A., additional, Bychkova, O., additional, Callier, S., additional, Calvet, D., additional, Canderan, K., additional, Cankocak, K., additional, Cao, X., additional, Cappati, A., additional, Caraway, B., additional, Caregari, S., additional, Carty, C., additional, Cauchois, A., additional, Ceard, L., additional, Sunar Cerci, D., additional, Cerci, S., additional, Cerminara, G., additional, Chadeeva, M., additional, Charitonidis, N., additional, Chatterjee, R., additional, Chen, J.A., additional, Chen, Y.M., additional, Cheng, H.J., additional, Cheng, K.Y., additional, Cheung, H., additional, Chokheli, D., additional, Cipriani, M., additional, Čoko, D., additional, Couderc, F., additional, Cuba, E., additional, Danilov, M., additional, Dannheim, D., additional, Daoud, W., additional, Das, I., additional, Dauncey, P., additional, Davies, G., additional, Davignon, O., additional, Day, E., additional, Debbins, P., additional, Defranchis, M.M., additional, Delagnes, E., additional, Demiragli, Z., additional, Demirbas, U., additional, Derylo, G., additional, Diaz, D., additional, Diehl, L., additional, Dinaucourt, P., additional, Dincer, G.G., additional, Dittmann, J., additional, Dragicevic, M., additional, Dugad, S., additional, Dulucq, F., additional, Dumanoglu, I., additional, Dünser, M., additional, Dutta, S., additional, Dutta, V., additional, Edberg, T.K., additional, Elias, F., additional, Eno, S.C., additional, Ershov, Yu., additional, Extier, S., additional, Fahim, F., additional, Fallon, C., additional, Fedi, G., additional, Ferragina, L., additional, Forthomme, L., additional, Frahm, E., additional, Franzoni, G., additional, Freeman, J., additional, French, T., additional, Gandhi, P., additional, Ganjour, S., additional, Gao, X., additional, Ramos Garcia, M.T., additional, Garcia-Bellido, A., additional, Gastaldi, F., additional, Gastler, D., additional, Gecse, Z., additional, Germer, A., additional, Gerwig, H., additional, Gevin, O., additional, Ghosh, S., additional, Gilbert, A., additional, Gilbert, W., additional, Gill, K., additional, Gingu, C., additional, Gninenko, S., additional, Golunov, A., additional, Golutvin, I., additional, Gonultas, B., additional, Gorbounov, N., additional, Gouskos, L., additional, Gray, A.B., additional, Grieco, C., additional, Grönroos, S., additional, Gu, Y., additional, Guilloux, F., additional, Gurpinar Guler, E., additional, Guler, Y., additional, Gülmez, E., additional, Guo, J., additional, Gutti, H., additional, Hakimi, A., additional, Hammer, M., additional, Hassanshahi, H.M., additional, Hatakeyama, K., additional, Hazen, E., additional, Heering, A., additional, Hegde, V., additional, Heintz, U., additional, Hinton, N., additional, Hirschauer, J., additional, Hoff, J., additional, Hou, W.-S., additional, Hou, X., additional, Hua, H., additional, Hussain, A., additional, Incandela, J., additional, Irshad, A., additional, Isik, C., additional, Jain, S., additional, Jaroslavceva, J., additional, Jheng, H.R., additional, Joshi, U., additional, Kaadze, K., additional, Kachanov, V., additional, Kalipoliti, L., additional, Kaminskiy, A., additional, Kanuganti, A.R., additional, Kao, Y.-W., additional, Kapoor, A., additional, Kara, O., additional, Karneyeu, A., additional, Kałuzińska, O., additional, Kaya, M., additional, Kaya, O., additional, Kazhykharim, Y., additional, Khan, F.A., additional, Khukhunaishvili, A., additional, Kieseler, J., additional, Kilpatrick, M., additional, Kim, S., additional, Koetz, K., additional, Kolberg, T., additional, Komm, M., additional, Köseyan, O.K., additional, Kraus, V., additional, Krawczyk, M., additional, Kristiansen, K., additional, Kristić, A., additional, Krohn, M., additional, Kronheim, B., additional, Krüger, K., additional, Kulis, S., additional, Kumar, M., additional, Kunori, S., additional, Kuo, C.M., additional, Kuryatkov, V., additional, Kyre, S., additional, Lai, Y., additional, Lamichhane, K., additional, Landsberg, G., additional, Lange, C., additional, Langford, J., additional, Lee, M.Y., additional, Lee, S.-W., additional, Stahl Leiton, A.G., additional, Levin, A., additional, Li, A., additional, Li, J.H., additional, Li, Y.Y., additional, Liang, Z., additional, Liao, H., additional, Lin, Z., additional, Lincoln, D., additional, Linssen, L., additional, Lipton, R., additional, Liu, G., additional, Liu, Y., additional, Lobanov, A., additional, Lohezic, V., additional, Lomidze, D., additional, Lu, R.-S., additional, Lupi, M., additional, Lysova, I., additional, Magnan, A.-M., additional, Magniette, F., additional, Mahjoub, A., additional, Meier, B., additional, Malakhov, A., additional, Mallios, S., additional, Mandjavize, I., additional, Mannelli, M., additional, Mans, J., additional, Marchioro, A., additional, Martelli, A., additional, Martinez, G., additional, Masterson, P., additional, Matthewman, M., additional, Mayekar, S.N., additional, David, A., additional, Coco Mendez, S., additional, Meng, B., additional, Menkel, A.., additional, Mestvirishvili, A., additional, Milella, G., additional, Mirza, I., additional, Moccia, S., additional, Mohanty, G.B., additional, Monti, F., additional, Moortgat, F.W., additional, Morrissey, I., additional, Motta, J., additional, Murthy, S., additional, Musić, J., additional, Musienko, Y., additional, Nabili, S., additional, Nguyen, M., additional, Nikitenko, A., additional, Noonan, D., additional, Noy, M., additional, Nurdan, K., additional, Wulansatiti Nursanto, M., additional, Ochando, C., additional, Odell, N., additional, Okawa, H., additional, Onel, Y., additional, Ortez, W., additional, Ozegović, J., additional, Ozkorucuklu, S., additional, Paganis, E., additional, Palmer, C.A., additional, Pandey, S., additional, Pantaleo, F., additional, Papageorgakis, C., additional, Papakrivopoulos, I., additional, Paranjpe, M., additional, Parshook, J., additional, Pastika, N., additional, Paulini, M., additional, Peltola, T., additional, Peng, N., additional, Buchot Perraguin, A., additional, Petiot, P., additional, Pierre-Emile, T., additional, Vicente Barreto Pinto, M., additional, Popova, E., additional, Prosper, H., additional, Prvan, M., additional, Puljak, I., additional, Qasim, S.R., additional, Qu, H., additional, Quast, T., additional, Quinn, R., additional, Quinnan, M., additional, Rao, K.K., additional, Rapacz, K., additional, Raux, L., additional, Redjeb, W., additional, Reinecke, M., additional, Revering, M., additional, Roberts, A., additional, Sanchez Rodriguez, A.M., additional, Rohlf, J., additional, Romanteau, T., additional, Rosado, M., additional, Rose, A., additional, Rovere, M., additional, Roy, A., additional, Rubinov, P., additional, Rusack, R., additional, Rusinov, V., additional, Ryjov, V., additional, Sahin, O.M., additional, Salerno, R., additional, Saradhy, R., additional, Sarbandi, K., additional, Sarkar, T., additional, Sarkisla, M.A., additional, Sauvan, J.B., additional, Schmidt, I., additional, Schmitt, M., additional, Scott, E., additional, Seez, C., additional, Sefkow, F., additional, Selivanova, D., additional, Sharma, S., additional, Shelake, M., additional, Shenai, A., additional, Shukla, R., additional, Sicking, E., additional, De Silva, M., additional, Silva, P., additional, Simkina, P., additional, Simsek, A.E., additional, Sirois, Y., additional, Smirnov, V., additional, Sobering, T.J., additional, Spencer, E., additional, Srimanobhas, N., additional, Steen, A., additional, Strait, J., additional, Strobbe, N., additional, Su, X.F., additional, Mantilla Suarez, C., additional, Sukhov, E., additional, Sulak, L., additional, Sun, L., additional, Suryadevara, P., additional, Syal, C., additional, de La Taille, C., additional, Tali, B., additional, Tan, C.L., additional, Tao, J., additional, Tarabini, A., additional, Tatli, T., additional, Thaus, R., additional, Taylor, R.D., additional, Tekten, S., additional, Thienpont, D., additional, Tiley, C., additional, Tiras, E., additional, Titov, M., additional, Tlisov, D., additional, Tok, U.G., additional, Kayis Topaksu, A., additional, Troska, J., additional, Tsai, L.-S., additional, Tsamalaidze, Z., additional, Tsipolitis, G., additional, Tsirou, A., additional, Undleeb, S., additional, Urbanski, D., additional, Uslan, E., additional, Ustinov, V., additional, Uzunian, A., additional, Varela, J., additional, Velasco, M., additional, Vernazza, E., additional, Viazlo, O., additional, Vichoudis, P., additional, Virdee, T., additional, Voirin, E., additional, Vojinoviç, M., additional, Vojinovic, M., additional, Wade, A., additional, Wang, C., additional, Wang, C.C., additional, Wang, D., additional, Wang, F., additional, Wang, X., additional, Wang, Z., additional, Wayne, M., additional, Webb, S.N., additional, Whitbeck, A., additional, Wickwire, R., additional, Wilson, J.S., additional, Wu, H.Y., additional, Wu, L., additional, Xiao, M., additional, Yang, J., additional, Yeh, C.H., additional, Yohay, R., additional, Yu, D., additional, Yu, S.S., additional, Yuan, C., additional, Miao, Y., additional, Yumiceva, F., additional, Yusuff, I., additional, Zabi, A., additional, Zacharopoulou, A., additional, Zamiatin, N., additional, Zarubin, A., additional, Zehetner, P., additional, Zhang, H., additional, Zhang, J., additional, Zhang, Y., additional, Zhang, Z., additional, and Zhao, X., additional

Published
2023
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69. Performance of the CMS High Granularity Calorimeter prototype to charged pion beams of 20–300 GeV/c

Author

Acar, B., primary, Adamov, G., additional, Adloff, C., additional, Afanasiev, S., additional, Akchurin, N., additional, Akgün, B., additional, Alhusseini, M., additional, Alison, J., additional, Figueiredo de sa Sousa de Almeida, J.P., additional, Dias de Almeida, P.G., additional, Alpana, A., additional, Alyari, M., additional, Andreev, I., additional, Aras, U., additional, Aspell, P., additional, Atakisi, I.O., additional, Bach, O., additional, Baden, A., additional, Bakas, G., additional, Bakshi, A., additional, Banerjee, S., additional, De Barbaro, P., additional, Bargassa, P., additional, Barney, D., additional, Beaudette, F., additional, Beaujean, F., additional, Becheva, E., additional, Becker, A., additional, Behera, P., additional, Belloni, A., additional, Bergauer, T., additional, El Berni, M., additional, Besancon, M., additional, Bhattacharya, S., additional, Bhowmik, D., additional, Bilki, B., additional, Bilokin, S., additional, Blazey, G.C., additional, Blekman, F., additional, Bloch, P., additional, Bodek, A., additional, Bonanomi, M., additional, Bonis, J., additional, Bonnemaison, A., additional, Bonomally, S., additional, Borg, J., additional, Bouyjou, F., additional, Bower, N., additional, Braga, D., additional, Brennan, L., additional, Brianne, E., additional, Brondolin, E., additional, Bryant, P., additional, Buhmann, E., additional, Buhmann, P., additional, Butler-Nalin, A., additional, Bychkova, O., additional, Callier, S., additional, Calvet, D., additional, Canderan, K., additional, Cankocak, K., additional, Cao, X., additional, Cappati, A., additional, Caraway, B., additional, Caregari, S., additional, Carty, C., additional, Cauchois, A., additional, Ceard, L., additional, Cerci, S., additional, Sunar Cerci, D., additional, Cerminara, G., additional, Chadeeva, M., additional, Charitonidis, N., additional, Chatterjee, R., additional, Chen, Y.M., additional, Chen, J.A., additional, Cheng, K.Y., additional, Cheng, H.J., additional, Cheung, H., additional, Chokheli, D., additional, Cipriani, M., additional, Čoko, D., additional, Couderc, F., additional, Cuba, E., additional, Danilov, M., additional, Dannheim, D., additional, Daoud, W., additional, Das, I., additional, Dauncey, P., additional, David, A., additional, Davies, G., additional, Davignon, O., additional, Day, E., additional, Debbins, P., additional, Defranchis, M.M., additional, Delagnes, E., additional, Demiragli, Z., additional, Demirbas, U., additional, Derylo, G., additional, Diaz, D., additional, Diehl, L., additional, Dinaucourt, P., additional, Dincer, G.G., additional, Dittmann, J., additional, Dragicevic, M., additional, Dugad, S., additional, Dulucq, F., additional, Dumanoglu, I., additional, Dünser, M., additional, Dutta, S., additional, Dutta, V., additional, Edberg, T.K., additional, Elias, F., additional, Emberger, L., additional, Eno, S.C., additional, Ershov, Yu., additional, Extier, S., additional, Fahim, F., additional, Fallon, C., additional, Sarbandi Fard, K., additional, Fedi, G., additional, Ferragina, L., additional, Forthomme, L., additional, Frahm, E., additional, Franzoni, G., additional, Freeman, J., additional, French, T., additional, Gadow, K., additional, Gandhi, P., additional, Ganjour, S., additional, Gao, X., additional, Ramos Garcia, M.T., additional, Garcia-Bellido, A., additional, Garutti, E., additional, Gastaldi, F., additional, Gastler, D., additional, Gecse, Z., additional, Germer, A., additional, Gerwig, H., additional, Gevin, O., additional, Ghosh, S., additional, Gilbert, W., additional, Gilbert, A., additional, Gill, K., additional, Gingu, C., additional, Gninenko, S., additional, Golunov, A., additional, Golutvin, I., additional, Gonultas, B., additional, Gorbounov, N., additional, Göttlicher, P., additional, Gouskos, L., additional, Graf, C., additional, Gray, A.B., additional, Grieco, C., additional, Grönroos, S., additional, Gu, Y., additional, Guilloux, F., additional, Guler, Y., additional, Gurpinar Guler, E., additional, Gülmez, E., additional, Guo, J., additional, Gutti, H., additional, Hakimi, A., additional, Hammer, M., additional, Hartbrich, O., additional, Hassanshahi, H.M., additional, Hatakeyama, K., additional, Hazen, E., additional, Heering, A., additional, Hegde, V., additional, Heintz, U., additional, Heuchel, D., additional, Hinton, N., additional, Hirschauer, J., additional, Hoff, J., additional, Hou, X., additional, Hou, W.-S., additional, Hua, H., additional, Huck, S., additional, Hussain, A., additional, Incandela, J., additional, Irles, A., additional, Irshad, A., additional, Isik, C., additional, Jain, S., additional, Jaroslavceva, J., additional, Jheng, H.R., additional, Joshi, U., additional, Kaadze, K., additional, Kachanov, V., additional, Kałuzińska, O., additional, Kalipoliti, L., additional, Kaminskiy, A., additional, Kanuganti, A.R., additional, Kao, Y.-W., additional, Kapoor, A., additional, Kara, O., additional, Karneyeu, A., additional, Kaya, M., additional, Kaya, O., additional, Kazhykharim, Y., additional, Khan, F.A., additional, Khukhunaishvili, A., additional, Kieseler, J., additional, Kilpatrick, M., additional, Kim, S., additional, Koetz, K., additional, Kolberg, T., additional, Komm, M., additional, Köseyan, O.K., additional, Kraus, V., additional, Krawczyk, M., additional, Kristiansen, K., additional, Kristić, A., additional, Krohn, M., additional, Kronheim, B., additional, Krüger, K., additional, Kulis, S., additional, Kumar, M., additional, Kunori, S., additional, Kuo, C.M., additional, Kuryatkov, V., additional, Kvasnicka, J., additional, Kyre, S., additional, Lai, Y., additional, Lamichhane, K., additional, Landsberg, G., additional, Lange, C., additional, Langford, J., additional, Laurien, S., additional, Lee, M.Y., additional, Lee, S.-W., additional, Stahl Leiton, A.G., additional, Levin, A., additional, Li, J.H., additional, Li, Y.Y., additional, Li, A., additional, Liang, Z., additional, Liao, H., additional, Lin, Z., additional, Lincoln, D., additional, Linssen, L., additional, Lipton, R., additional, Liu, Y., additional, Liu, G., additional, Lobanov, A., additional, Lohezic, V., additional, Lomidze, D., additional, Lu, S., additional, Lu, R.-S., additional, Lupi, M., additional, Lysova, I., additional, Magnan, A.-M., additional, Magniette, F., additional, Mahjoub, A., additional, Malakhov, A., additional, Mallios, S., additional, Mandjavize, I., additional, Mannelli, M., additional, Mans, J., additional, Marchioro, A., additional, Martelli, A., additional, Martens, S., additional, Martinez, G., additional, Masterson, P., additional, Matthewman, M., additional, Matysek, M., additional, Mayekar, S.N., additional, Meier, B., additional, Coco Mendez, S., additional, Meng, B., additional, Menkel, A., additional, Mestvirishvili, A., additional, Miao, Y., additional, Milella, G., additional, Mirza, I., additional, Moccia, S., additional, Mohanty, G.B., additional, Monti, F., additional, Moortgat, F.W., additional, Morrissey, I., additional, Motta, J., additional, Murthy, S., additional, Musić, J., additional, Musienko, Y., additional, Nabili, S., additional, Nguyen, M., additional, Nikitenko, A., additional, Noonan, D., additional, Noy, M., additional, Nurdan, K., additional, Wulansatiti Nursanto, M., additional, Ochando, C., additional, Odell, N., additional, Okawa, H., additional, Onel, Y., additional, Ortez, W., additional, Ozegović, J., additional, Ozkorucuklu, S., additional, Paganis, E., additional, Palmer, C.A., additional, Pandey, S., additional, Pantaleo, F., additional, Papageorgakis, C., additional, Papakrivopoulos, I., additional, Paranjpe, M., additional, Parshook, J., additional, Pastika, N., additional, Paulini, M., additional, Peitzmann, T., additional, Peltola, T., additional, Peng, N., additional, Buchot Perraguin, A., additional, Petiot, P., additional, Pierre-Emile, T., additional, Vicente Barreto Pinto, M., additional, Popova, E., additional, Pöschl, R., additional, Prosper, H., additional, Prvan, M., additional, Puljak, I., additional, Qasim, S.R., additional, Qu, H., additional, Quast, T., additional, Quinn, R., additional, Quinnan, M., additional, Rane, A., additional, Rao, K.K., additional, Rapacz, K., additional, Raux, L., additional, Redjeb, W., additional, Reinecke, M., additional, Revering, M., additional, Richard, F., additional, Roberts, A., additional, Sanchez Rodriguez, A.M., additional, Rohlf, J., additional, Rolph, J., additional, Romanteau, T., additional, Rosado, M., additional, Rose, A., additional, Rovere, M., additional, Roy, A., additional, Rubinov, P., additional, Rusack, R., additional, Rusinov, V., additional, Ryjov, V., additional, Sahin, O.M., additional, Salerno, R., additional, Saradhy, R., additional, Sarkar, T., additional, Sarkisla, M.A., additional, Sauvan, J.B., additional, Schmidt, I., additional, Schmitt, M., additional, Schuwalow, S., additional, Scott, E., additional, Seez, C., additional, Sefkow, F., additional, Selivanova, D., additional, Sharma, S., additional, Shelake, M., additional, Shenai, A., additional, Shukla, R., additional, Sicking, E., additional, De Silva, M., additional, Silva, P., additional, Simkina, P., additional, Simon, F., additional, Simsek, A.E., additional, Sirois, Y., additional, Smirnov, V., additional, Sobering, T.J., additional, Spencer, E., additional, Srimanobhas, N., additional, Steen, A., additional, Strait, J., additional, Strobbe, N., additional, Su, X.F., additional, Mantilla Suarez, C., additional, Sudo, Y., additional, Sukhov, E., additional, Sulak, L., additional, Sun, L., additional, Suryadevara, P., additional, Syal, C., additional, de La Taille, C., additional, Tali, B., additional, Tan, C.L., additional, Tao, J., additional, Tarabini, A., additional, Tatli, T., additional, Taylor, R.D., additional, Tekten, S., additional, Thaus, R., additional, Thiebault, A., additional, Thienpont, D., additional, Tiley, C., additional, Tiras, E., additional, Titov, M., additional, Tlisov, D., additional, Tok, U.G., additional, Kayis Topaksu, A., additional, Troska, J., additional, Tsai, L.-S., additional, Tsamalaidze, Z., additional, Tsipolitis, G., additional, Tsirou, A., additional, Undleeb, S., additional, Urbanski, D., additional, Uslan, E., additional, Ustinov, V., additional, Uzunian, A., additional, Varela, J., additional, Velasco, M., additional, Vernazza, E., additional, Viazlo, O., additional, Vichoudis, P., additional, Virdee, T., additional, Voirin, E., additional, Vojinoviç, M., additional, Vojinovic, M., additional, Wade, A., additional, Wang, C., additional, Wang, C.C., additional, Wang, D., additional, Wang, F., additional, Wang, X., additional, Wang, Z., additional, Wayne, M., additional, Webb, S.N., additional, Whitbeck, A., additional, Wickwire, R., additional, Wilson, J.S., additional, Wu, L., additional, Wu, H.Y., additional, Xiao, M., additional, Yang, J., additional, H Yeh, C., additional, Yohay, R., additional, Yu, D., additional, Yu, S.S., additional, Yuan, C., additional, Yumiceva, F., additional, Yusuff, I., additional, Zabi, A., additional, Zacharopoulou, A., additional, Zamiatin, N., additional, Zarubin, A., additional, Zehetner, P., additional, Zerwas, D., additional, Zhang, J., additional, Zhang, Y., additional, Zhang, H., additional, Zhang, Z., additional, and Zhao, X., additional

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2023
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72. Response of a CMS HGCAL silicon-pad electromagnetic calorimeter prototype to 20-300 GeV positrons

Author

Acar, B, Adamov, G, Adloff, C, Afanasiev, S, Akchurin, N, Akgun, B, Khan, F, Alhusseini, M, Alison, J, Alpana, A, Altopp, G, Alyari, M, An, S, Anagul, S, Andreev, I, Aspell, P, Atakisi, I, Bach, O, Baden, A, Bakas, G, Bakshi, A, Bannerjee, S, Bargassa, P, Barney, D, Beaudette, F, Beaujean, F, Becheva, E, Becker, A, Behera, P, Belloni, A, Bergauer, T, Besancon, M, Bhattacharya, S, Bhowmik, D, Bilki, B, Bloch, P, Bodek, A, Bonanomi, M, Bonnemaison, A, Bonomally, S, Borg, J, Bouyjou, F, Bower, N, Braga, D, Brashear, J, Brondolin, E, Bryant, P, Buchot Perraguin, A, Bueghly, J, Burkle, B, Butler-Nalin, A, Bychkova, O, Callier, S, Calvet, D, Cao, X, Cappati, A, Caraway, B, Caregari, S, Cauchois, A, Ceard, L, Cekmecelioglu, Y, Cerci, S, Cerminara, G, Chadeeva, M, Charitonidis, N, Chatterjee, R, Chen, Y, Chen, Z, Cheng, H, Cheng, K, Chernichenko, S, Cheung, H, Chien, C, Choudhury, S, Coko, D, Collura, G, Couderc, F, Danilov, M, Dannheim, D, Daoud, W, Dauncey, P, David, A, Davies, G, Davignon, O, Day, E, Debarbaro, P, De Guio, F, De La Taille, C, De Silva, M, Debbins, P, Defranchis, M, Delagnes, E, Deltoro Berrio, J, Derylo, G, Dias De Almeida, P, Diaz, D, Dinaucourt, P, Dittmann, J, Dragicevic, M, Dugad, S, Dulucq, F, Dumanoglu, I, Dutta, V, Dutta, S, Dunser, M, Eckdahl, J, Edberg, T, El Berni, M, Elias, F, Eno, S, Ershov, Y, Everaerts, P, Extier, S, Fahim, F, Fallon, C, Fedi, G, Fontana Santos Alves, B, Frahm, E, Franzoni, G, Freeman, J, French, T, Gandhi, P, Ganjour, S, Gao, X, Garcia-Bellido, A, Gastaldi, F, Gecse, Z, Geerebaert, Y, Gerwig, H, Gevin, O, Ghosh, S, Gilbert, A, Gilbert, W, Gill, K, Gingu, C, Gninenko, S, Golunov, A, Golutvin, I, Gonzalez, T, Gorbounov, N, Gouskos, L, Gray, A, Gu, Y, Guilloux, F, Guler, Y, Gulmez, E, Guo, J, Gurpinar Guler, E, Hammer, M, Hassanshahi, H, Hatakeyama, K, Heering, A, Hegde, V, Heintz, U, Hinton, N, Hirschauer, J, Hoff, J, Hou, W, Hou, X, Hua, H, Incandela, J, Irshad, A, Isik, C, Jain, S, Jheng, H, Joshi, U, Kachanov, V, Kalinin, A, Kalipoliti, L, Kaminskiy, A, Kapoor, A, Kara, O, Karneyeu, A, Kaya, M, Kaya, O, Kayis Topaksu, A, Khukhunaishvili, A, Kiesler, J, Kilpatrick, M, Kim, S, Koetz, K, Kolberg, T, Koseyan, O, Kristic, A, Krohn, M, Kruger, K, Kulagin, N, Kulis, S, Kunori, S, Kuo, C, Kuryatkov, V, Kyre, S, Lai, Y, Lamichhane, K, Landsberg, G, Lange, C, Langford, J, Lee, M, Levin, A, Li, A, Li, B, Li, J, Li, Y, Liao, H, Lincoln, D, Linssen, L, Lipton, R, Liu, Y, Lobanov, A, Lu, R, Lupi, M, Lysova, I, Magnan, A, Magniette, F, Mahjoub, A, Maier, A, Malakhov, A, Mallios, S, Mandjavize, I, Mannelli, M, Mans, J, Marchioro, A, Martelli, A, Martinez, G, Masterson, P, Meng, B, Mengke, T, Mestvirishvili, A, Mirza, I, Moccia, S, Mohanty, G, Monti, F, Morrissey, I, Murthy, S, Music, J, Musienko, Y, Nabili, S, Nagar, A, Nguyen, M, Nikitenko, A, Noonan, D, Noy, M, Nurdan, K, Ochando, C, Odegard, B, Odell, N, Okawa, H, Onel, Y, Ortez, W, Ozegovic, J, Ozkorucuklu, S, Paganis, E, Pagenkopf, D, Palladino, V, Pandey, S, Pantaleo, F, Papageorgakis, C, Papakrivopoulos, I, Parshook, J, Pastika, N, Paulini, M, Paulitsch, P, Peltola, T, Pereira Gomes, R, Perkins, H, Petiot, P, Pierre-Emile, T, Pitters, F, Popova, E, Prosper, H, Prvan, M, Puljak, I, Qu, H, Quast, T, Quinn, R, Quinnan, M, Ramos Garcia, M, Rao, K, Rapacz, K, Raux, L, Reichenbach, G, Reinecke, M, Revering, M, Roberts, A, Romanteau, T, Rose, A, Rovere, M, Roy, A, Rubinov, P, Rusack, R, Rusinov, V, Ryjov, V, Sahin, O, Salerno, R, Sanchez Rodriguez, A, Saradhy, R, Sarkar, T, Sarkisla, M, Sauvan, J, Schmidt, I, Schmitt, M, Scott, E, Seez, C, Sefkow, F, Sharma, S, Shein, I, Shenai, A, Shukla, R, Sicking, E, Sieberer, P, Silva, P, Simsek, A, Sirois, Y, Smirnov, V, Sozbilir, U, Spencer, E, Steen, A, Strait, J, Strobbe, N, Su, J, Sukhov, E, Sun, L, Sunar Cerci, D, Syal, C, Tali, B, Tan, C, Tao, J, Tastan, I, Tatli, T, Thaus, R, Tekten, S, Thienpont, D, Tiras, E, Titov, M, Tlisov, D, Tok, U, Troska, J, Tsai, L, Tsamalaidze, Z, Tsipolitis, G, Tsirou, A, Tyurin, N, Undleeb, S, Urbanski, D, Ustinov, V, Uzunian, A, Van De Klundert, M, Varela, J, Velasco, M, Viazlo, O, Barreto Pinto, M, Vichoudis, P, Virdee, T, Vizinho De Oliveira, R, Voelker, J, Voirin, E, Vojinovic, M, Wade, A, Wang, C, Wang, F, Wang, X, Wang, Z, Wayne, M, Webb, S, Whitbeck, A, White, D, Wickwire, R, Wilson, J, Winter, D, Wu, H, Wu, L, Wulansatiti Nursanto, M, Yeh, C, Yohay, R, Yu, D, Yu, G, Yu, S, Yuan, C, Yumiceva, F, Yusuff, I, Zacharopoulou, A, Zamiatin, N, Zarubin, A, Zenz, S, Zghiche, A, Zhang, H, Zhang, J, Zhang, Y, Zhang, Z, Acar B., Adamov G., Adloff C., Afanasiev S., Akchurin N., Akgun B., Khan F. A., Alhusseini M., Alison J., Alpana A., Altopp G., Alyari M., An S., Anagul S., Andreev I., Aspell P., Atakisi I. O., Bach O., Baden A., Bakas G., Bakshi A., Bannerjee S., Bargassa P., Barney D., Beaudette F., Beaujean F., Becheva E., Becker A., Behera P., Belloni A., Bergauer T., Besancon M., Bhattacharya S., Bhowmik D., Bilki B., Bloch P., Bodek A., Bonanomi M., Bonnemaison A., Bonomally S., Borg J., Bouyjou F., Bower N., Braga D., Brashear J., Brondolin E., Bryant P., Buchot Perraguin A., Bueghly J., Burkle B., Butler-Nalin A., Bychkova O., Callier S., Calvet D., Cao X., Cappati A., Caraway B., Caregari S., Cauchois A., Ceard L., Cekmecelioglu Y. C., Cerci S., Cerminara G., Chadeeva M., Charitonidis N., Chatterjee R., Chen Y. M., Chen Z., Cheng H. J., Cheng K. Y., Chernichenko S., Cheung H., Chien C. 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M., Hatakeyama K., Heering A., Hegde V., Heintz U., Hinton N., Hirschauer J., Hoff J., Hou W. -S., Hou X., Hua H., Incandela J., Irshad A., Isik C., Jain S., Jheng H. R., Joshi U., Kachanov V., Kalinin A., Kalipoliti L., Kaminskiy A., Kapoor A., Kara O., Karneyeu A., Kaya M., Kaya O., Kayis Topaksu A., Khukhunaishvili A., Kiesler J., Kilpatrick M., Kim S., Koetz K., Kolberg T., Koseyan O. K., Kristic A., Krohn M., Kruger K., Kulagin N., Kulis S., Kunori S., Kuo C. M., Kuryatkov V., Kyre S., Lai Y., Lamichhane K., Landsberg G., Lange C., Langford J., Lee M. Y., Levin A., Li A., Li B., Li J. H., Li Y. Y., Liao H., Lincoln D., Linssen L., Lipton R., Liu Y., Lobanov A., Lu R. -S., Lupi M., Lysova I., Magnan A. -M., Magniette F., Mahjoub A., Maier A. A., Malakhov A., Mallios S., Mandjavize I., Mannelli M., Mans J., Marchioro A., Martelli A., Martinez G., Masterson P., Meng B., Mengke T., Mestvirishvili A., Mirza I., Moccia S., Mohanty G. 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S., Yuan C., Yumiceva F., Yusuff I., Zacharopoulou A., Zamiatin N., Zarubin A., Zenz S., Zghiche A., Zhang H., Zhang J., Zhang Y., Zhang Z., Acar, B, Adamov, G, Adloff, C, Afanasiev, S, Akchurin, N, Akgun, B, Khan, F, Alhusseini, M, Alison, J, Alpana, A, Altopp, G, Alyari, M, An, S, Anagul, S, Andreev, I, Aspell, P, Atakisi, I, Bach, O, Baden, A, Bakas, G, Bakshi, A, Bannerjee, S, Bargassa, P, Barney, D, Beaudette, F, Beaujean, F, Becheva, E, Becker, A, Behera, P, Belloni, A, Bergauer, T, Besancon, M, Bhattacharya, S, Bhowmik, D, Bilki, B, Bloch, P, Bodek, A, Bonanomi, M, Bonnemaison, A, Bonomally, S, Borg, J, Bouyjou, F, Bower, N, Braga, D, Brashear, J, Brondolin, E, Bryant, P, Buchot Perraguin, A, Bueghly, J, Burkle, B, Butler-Nalin, A, Bychkova, O, Callier, S, Calvet, D, Cao, X, Cappati, A, Caraway, B, Caregari, S, Cauchois, A, Ceard, L, Cekmecelioglu, Y, Cerci, S, Cerminara, G, Chadeeva, M, Charitonidis, N, Chatterjee, R, Chen, Y, Chen, Z, Cheng, H, Cheng, K, Chernichenko, S, Cheung, H, Chien, C, Choudhury, S, Coko, D, Collura, G, Couderc, F, Danilov, M, Dannheim, D, Daoud, W, Dauncey, P, David, A, Davies, G, Davignon, O, Day, E, Debarbaro, P, De Guio, F, De La Taille, C, De Silva, M, Debbins, P, Defranchis, M, Delagnes, E, Deltoro Berrio, J, Derylo, G, Dias De Almeida, P, Diaz, D, Dinaucourt, P, Dittmann, J, Dragicevic, M, Dugad, S, Dulucq, F, Dumanoglu, I, Dutta, V, Dutta, S, Dunser, M, Eckdahl, J, Edberg, T, El Berni, M, Elias, F, Eno, S, Ershov, Y, Everaerts, P, Extier, S, Fahim, F, Fallon, C, Fedi, G, Fontana Santos Alves, B, Frahm, E, Franzoni, G, Freeman, J, French, T, Gandhi, P, Ganjour, S, Gao, X, Garcia-Bellido, A, Gastaldi, F, Gecse, Z, Geerebaert, Y, Gerwig, H, Gevin, O, Ghosh, S, Gilbert, A, Gilbert, W, Gill, K, Gingu, C, Gninenko, S, Golunov, A, Golutvin, I, Gonzalez, T, Gorbounov, N, Gouskos, L, Gray, A, Gu, Y, Guilloux, F, Guler, Y, Gulmez, E, Guo, J, Gurpinar Guler, E, Hammer, M, Hassanshahi, H, Hatakeyama, K, Heering, A, Hegde, V, Heintz, U, Hinton, N, Hirschauer, J, Hoff, J, Hou, W, Hou, X, Hua, H, Incandela, J, Irshad, A, Isik, C, Jain, S, Jheng, H, Joshi, U, Kachanov, V, Kalinin, A, Kalipoliti, L, Kaminskiy, A, Kapoor, A, Kara, O, Karneyeu, A, Kaya, M, Kaya, O, Kayis Topaksu, A, Khukhunaishvili, A, Kiesler, J, Kilpatrick, M, Kim, S, Koetz, K, Kolberg, T, Koseyan, O, Kristic, A, Krohn, M, Kruger, K, Kulagin, N, Kulis, S, Kunori, S, Kuo, C, Kuryatkov, V, Kyre, S, Lai, Y, Lamichhane, K, Landsberg, G, Lange, C, Langford, J, Lee, M, Levin, A, Li, A, Li, B, Li, J, Li, Y, Liao, H, Lincoln, D, Linssen, L, Lipton, R, Liu, Y, Lobanov, A, Lu, R, Lupi, M, Lysova, I, Magnan, A, Magniette, F, Mahjoub, A, Maier, A, Malakhov, A, Mallios, S, Mandjavize, I, Mannelli, M, Mans, J, Marchioro, A, Martelli, A, Martinez, G, Masterson, P, Meng, B, Mengke, T, Mestvirishvili, A, Mirza, I, Moccia, S, Mohanty, G, Monti, F, Morrissey, I, Murthy, S, Music, J, Musienko, Y, Nabili, S, Nagar, A, Nguyen, M, Nikitenko, A, Noonan, D, Noy, M, Nurdan, K, Ochando, C, Odegard, B, Odell, N, Okawa, H, Onel, Y, Ortez, W, Ozegovic, J, Ozkorucuklu, S, Paganis, E, Pagenkopf, D, Palladino, V, Pandey, S, Pantaleo, F, Papageorgakis, C, Papakrivopoulos, I, Parshook, J, Pastika, N, Paulini, M, Paulitsch, P, Peltola, T, Pereira Gomes, R, Perkins, H, Petiot, P, Pierre-Emile, T, Pitters, F, Popova, E, Prosper, H, Prvan, M, Puljak, I, Qu, H, Quast, T, Quinn, R, Quinnan, M, Ramos Garcia, M, Rao, K, Rapacz, K, Raux, L, Reichenbach, G, Reinecke, M, Revering, M, Roberts, A, Romanteau, T, Rose, A, Rovere, M, Roy, A, Rubinov, P, Rusack, R, Rusinov, V, Ryjov, V, Sahin, O, Salerno, R, Sanchez Rodriguez, A, Saradhy, R, Sarkar, T, Sarkisla, M, Sauvan, J, Schmidt, I, Schmitt, M, Scott, E, Seez, C, Sefkow, F, Sharma, S, Shein, I, Shenai, A, Shukla, R, Sicking, E, Sieberer, P, Silva, P, Simsek, A, Sirois, Y, Smirnov, V, Sozbilir, U, Spencer, E, Steen, A, Strait, J, Strobbe, N, Su, J, Sukhov, E, Sun, L, Sunar Cerci, D, Syal, C, Tali, B, Tan, C, Tao, J, Tastan, I, Tatli, T, Thaus, R, Tekten, S, Thienpont, D, Tiras, E, Titov, M, Tlisov, D, Tok, U, Troska, J, Tsai, L, Tsamalaidze, Z, Tsipolitis, G, Tsirou, A, Tyurin, N, Undleeb, S, Urbanski, D, Ustinov, V, Uzunian, A, Van De Klundert, M, Varela, J, Velasco, M, Viazlo, O, Barreto Pinto, M, Vichoudis, P, Virdee, T, Vizinho De Oliveira, R, Voelker, J, Voirin, E, Vojinovic, M, Wade, A, Wang, C, Wang, F, Wang, X, Wang, Z, Wayne, M, Webb, S, Whitbeck, A, White, D, Wickwire, R, Wilson, J, Winter, D, Wu, H, Wu, L, Wulansatiti Nursanto, M, Yeh, C, Yohay, R, Yu, D, Yu, G, Yu, S, Yuan, C, Yumiceva, F, Yusuff, I, Zacharopoulou, A, Zamiatin, N, Zarubin, A, Zenz, S, Zghiche, A, Zhang, H, Zhang, J, Zhang, Y, Zhang, Z, Acar B., Adamov G., Adloff C., Afanasiev S., Akchurin N., Akgun B., Khan F. 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H., Choudhury S., Coko D., Collura G., Couderc F., Danilov M., Dannheim D., Daoud W., Dauncey P., David A., Davies G., Davignon O., Day E., Debarbaro P., De Guio F., De La Taille C., De Silva M., Debbins P., Defranchis M. M., Delagnes E., Deltoro Berrio J. M., Derylo G., Dias De Almeida P. G., Diaz D., Dinaucourt P., Dittmann J., Dragicevic M., Dugad S., Dulucq F., Dumanoglu I., Dutta V., Dutta S., Dunser M., Eckdahl J., Edberg T. K., El Berni M., Elias F., Eno S. C., Ershov Y., Everaerts P., Extier S., Fahim F., Fallon C., Fedi G., Fontana Santos Alves B. A., Frahm E., Franzoni G., Freeman J., French T., Gandhi P., Ganjour S., Gao X., Garcia-Bellido A., Gastaldi F., Gecse Z., Geerebaert Y., Gerwig H., Gevin O., Ghosh S., Gilbert A., Gilbert W., Gill K., Gingu C., Gninenko S., Golunov A., Golutvin I., Gonzalez T., Gorbounov N., Gouskos L., Gray A. B., Gu Y., Guilloux F., Guler Y., Gulmez E., Guo J., Gurpinar Guler E., Hammer M., Hassanshahi H. M., Hatakeyama K., Heering A., Hegde V., Heintz U., Hinton N., Hirschauer J., Hoff J., Hou W. -S., Hou X., Hua H., Incandela J., Irshad A., Isik C., Jain S., Jheng H. R., Joshi U., Kachanov V., Kalinin A., Kalipoliti L., Kaminskiy A., Kapoor A., Kara O., Karneyeu A., Kaya M., Kaya O., Kayis Topaksu A., Khukhunaishvili A., Kiesler J., Kilpatrick M., Kim S., Koetz K., Kolberg T., Koseyan O. K., Kristic A., Krohn M., Kruger K., Kulagin N., Kulis S., Kunori S., Kuo C. M., Kuryatkov V., Kyre S., Lai Y., Lamichhane K., Landsberg G., Lange C., Langford J., Lee M. Y., Levin A., Li A., Li B., Li J. H., Li Y. Y., Liao H., Lincoln D., Linssen L., Lipton R., Liu Y., Lobanov A., Lu R. -S., Lupi M., Lysova I., Magnan A. -M., Magniette F., Mahjoub A., Maier A. A., Malakhov A., Mallios S., Mandjavize I., Mannelli M., Mans J., Marchioro A., Martelli A., Martinez G., Masterson P., Meng B., Mengke T., Mestvirishvili A., Mirza I., Moccia S., Mohanty G. B., Monti F., Morrissey I., Murthy S., Music J., Musienko Y., Nabili S., Nagar A., Nguyen M., Nikitenko A., Noonan D., Noy M., Nurdan K., Ochando C., Odegard B., Odell N., Okawa H., Onel Y., Ortez W., Ozegovic J., Ozkorucuklu S., Paganis E., Pagenkopf D., Palladino V., Pandey S., Pantaleo F., Papageorgakis C., Papakrivopoulos I., Parshook J., Pastika N., Paulini M., Paulitsch P., Peltola T., Pereira Gomes R., Perkins H., Petiot P., Pierre-Emile T., Pitters F., Popova E., Prosper H., Prvan M., Puljak I., Qu H., Quast T., Quinn R., Quinnan M., Ramos Garcia M. T., Rao K. K., Rapacz K., Raux L., Reichenbach G., Reinecke M., Revering M., Roberts A., Romanteau T., Rose A., Rovere M., Roy A., Rubinov P., Rusack R., Rusinov V., Ryjov V., Sahin O. M., Salerno R., Sanchez Rodriguez A. M., Saradhy R., Sarkar T., Sarkisla M. A., Sauvan J. B., Schmidt I., Schmitt M., Scott E., Seez C., Sefkow F., Sharma S., Shein I., Shenai A., Shukla R., Sicking E., Sieberer P., Silva P., Simsek A. E., Sirois Y., Smirnov V., Sozbilir U., Spencer E., Steen A., Strait J., Strobbe N., Su J. W., Sukhov E., Sun L., Sunar Cerci D., Syal C., Tali B., Tan C. L., Tao J., Tastan I., Tatli T., Thaus R., Tekten S., Thienpont D., Tiras E., Titov M., Tlisov D., Tok U. G., Troska J., Tsai L. -S., Tsamalaidze Z., Tsipolitis G., Tsirou A., Tyurin N., Undleeb S., Urbanski D., Ustinov V., Uzunian A., Van De Klundert M., Varela J., Velasco M., Viazlo O., Barreto Pinto M. V., Vichoudis P., Virdee T., Vizinho De Oliveira R., Voelker J., Voirin E., Vojinovic M., Wade A., Wang C., Wang F., Wang X., Wang Z., Wayne M., Webb S. N., Whitbeck A., White D., Wickwire R., Wilson J. S., Winter D., Wu H. Y., Wu L., Wulansatiti Nursanto M., Yeh C. H., Yohay R., Yu D., Yu G. B., Yu S. S., Yuan C., Yumiceva F., Yusuff I., Zacharopoulou A., Zamiatin N., Zarubin A., Zenz S., Zghiche A., Zhang H., Zhang J., Zhang Y., and Zhang Z.

Abstract

The Compact Muon Solenoid collaboration is designing a new high-granularity endcap calorimeter, HGCAL, to be installed later this decade. As part of this development work, a prototype system was built, with an electromagnetic section consisting of 14 double-sided structures, providing 28 sampling layers. Each sampling layer has an hexagonal module, where a multipad large-area silicon sensor is glued between an electronics circuit board and a metal baseplate. The sensor pads of approximately 1.1 cm2 are wire-bonded to the circuit board and are readout by custom integrated circuits. The prototype was extensively tested with beams at CERN's Super Proton Synchrotron in 2018. Based on the data collected with beams of positrons, with energies ranging from 20 to 300 GeV, measurements of the energy resolution and linearity, the position and angular resolutions, and the shower shapes are presented and compared to a detailed Geant4 simulation.

Published
2022

75. Induction or consolidation chemotherapy for unresectable stage III non-small-cell lung cancer patients treated with concurrent chemoradiation: a randomised phase II trial GFPC – IFCT 02-01

Author

Fournel, P., Talabard, J.N., Vergnenégre, A., Melloni, B., Decroisette, C., Clavére, P., Robinet, G., Bayle, S., Labat, J.P., Léna, H., Belleguic, C., Benchalal, M., Gervais, R., Rivière, A., Lerouge, D., Souquet, P.J., Gérinière, L., D'Hombres, A., Mornex, F., Le Caer, H., Tessier, E., Ramos, H., Chavaillon, J.M., Chouaid, C., Touboul, E., Bota, S., Thiberville, L., Gallocher, O., Quoix, E., Mennecier, B., Jung, G.M., Falchero, L., Paillotin, D., Schouabe, S., Jonveaux, E., Bout, J.C., Martin, P., Perol, M., Arpin, D., Martel-Lafay, I., Letreut, J., Poirier, R., Benyoub, A., Vernejoux, J.M., Trouette, R., Dansin, E., Berard, H., Pietra, J.C., Zalcman, G., Thomas, P., Zribi, A., Milleron, B., Lavolé, A., Coetmeur, D., Lamezec, B., Bonnamour, C., Grangeon, V., Suchaud, J.P., Créquit, J., Ramdane, S., Barre, P., Zawadi, M.A., Gimenez, C., Barlesi, F., Pignon, T., Grivaux, M., Blanchon, F., Mandet, J., Perdu, D., Cauchois, A., Delhoume, J.Y., Kin, B., Merle, P., Janicot, H., Verrelle, P., Auliac, J.B., Coscas, Y., Ducolone, A., Herman, D., Roquette, A., Fournel, Pierre, Vergnenégre, Alain, Robinet, Gilles, Léna, Hervé, Gervais, Radj, Le Caer, Hervé, Souquet, Pierre-Jean, Chavaillon, Jean-Michel, Bozonnat, Marie-Cécile, Daurès, Jean-Pierre, Chouaid, Christos, and Martel-Lafay, Isabelle

Published
2016
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77. Direct construction of quasi-involutory recursive-like MDS matrices from 2-cyclic codes

Author

Victor Cauchois, Pierre Loidreau, and Nabil Merkiche

Subjects
diffusion layers, MDS matrices, involutions, cyclic codes, Computer engineering. Computer hardware, TK7885-7895
Abstract

A good linear diffusion layer is a prerequisite in the design of block ciphers. Usually it is obtained by combining matrices with optimal diffusion property over the Sbox alphabet. These matrices are constructed either directly using some algebraic properties or by enumerating a search space, testing the optimal diffusion property for every element. For implementation purposes, two types of structures are considered: Structures where all the rows derive from the first row and recursive structures built from powers of companion matrices. In this paper, we propose a direct construction for new recursive-like MDS matrices. We show they are quasi-involutory in the sense that the matrix-vector product with the matrix or with its inverse can be implemented by clocking a same LFSR-like architecture. As a direct construction, performances do not outperform the best constructions found with exhaustive search. However, as a new type of construction, it offers alternatives for MDS matrices design.

Published
2017
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78. Tocilizumab versus anakinra in COVID-19: results from propensity score matching

Author

Arcani, Robin, primary, Correard, Florian, additional, Suchon, Pierre, additional, Kaplanski, Gilles, additional, Jean, Rodolphe, additional, Cauchois, Raphael, additional, Leprince, Marine, additional, Arcani, Vincent, additional, Seguier, Julie, additional, De Sainte Marie, Benjamin, additional, Andre, Baptiste, additional, Koubi, Marie, additional, Rossi, Pascal, additional, Gayet, Stéphane, additional, Gobin, Nirvina, additional, Garrido, Victoria, additional, Weiland, Joris, additional, Jouve, Elisabeth, additional, Couderc, Anne-Laure, additional, Villani, Patrick, additional, and Daumas, Aurélie, additional

Published
2023
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80. Modeling of the driver transverse profile for laser wakefield electron acceleration at APOLLON research facility

Author

Moulanier, I., primary, Dickson, L. T., additional, Ballage, C., additional, Vasilovici, O., additional, Gremaud, A., additional, Dobosz Dufrénoy, S., additional, Delerue, N., additional, Bernardi, L., additional, Mahjoub, A., additional, Cauchois, A., additional, Specka, A., additional, Massimo, F., additional, Maynard, G., additional, and Cros, B., additional

Published
2023
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81. Data from A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota

Author

Messaoudene, Meriem, primary, Pidgeon, Reilly, primary, Richard, Corentin, primary, Ponce, Mayra, primary, Diop, Khoudia, primary, Benlaifaoui, Myriam, primary, Nolin-Lapalme, Alexis, primary, Cauchois, Florent, primary, Malo, Julie, primary, Belkaid, Wiam, primary, Isnard, Stephane, primary, Fradet, Yves, primary, Dridi, Lharbi, primary, Velin, Dominique, primary, Oster, Paul, primary, Raoult, Didier, primary, Ghiringhelli, François, primary, Boidot, Romain, primary, Chevrier, Sandy, primary, Kysela, David T., primary, Brun, Yves V., primary, Falcone, Emilia Liana, primary, Pilon, Geneviève, primary, Oñate, Florian Plaza, primary, Gitton-Quent, Oscar, primary, Le Chatelier, Emmanuelle, primary, Durand, Sylvere, primary, Kroemer, Guido, primary, Elkrief, Arielle, primary, Marette, André, primary, Castagner, Bastien, primary, and Routy, Bertrand, primary

Published
2023
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82. Supplementary Figure from A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota

Author

Messaoudene, Meriem, primary, Pidgeon, Reilly, primary, Richard, Corentin, primary, Ponce, Mayra, primary, Diop, Khoudia, primary, Benlaifaoui, Myriam, primary, Nolin-Lapalme, Alexis, primary, Cauchois, Florent, primary, Malo, Julie, primary, Belkaid, Wiam, primary, Isnard, Stephane, primary, Fradet, Yves, primary, Dridi, Lharbi, primary, Velin, Dominique, primary, Oster, Paul, primary, Raoult, Didier, primary, Ghiringhelli, François, primary, Boidot, Romain, primary, Chevrier, Sandy, primary, Kysela, David T., primary, Brun, Yves V., primary, Falcone, Emilia Liana, primary, Pilon, Geneviève, primary, Oñate, Florian Plaza, primary, Gitton-Quent, Oscar, primary, Le Chatelier, Emmanuelle, primary, Durand, Sylvere, primary, Kroemer, Guido, primary, Elkrief, Arielle, primary, Marette, André, primary, Castagner, Bastien, primary, and Routy, Bertrand, primary

Published
2023
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83. Supplementary Data, Figure 1 from Serum CD95L Level Correlates with Tumor Immune Infiltration and Is a Positive Prognostic Marker for Advanced High-Grade Serous Ovarian Cancer

Author

De La Motte Rouge, Thibault, primary, Corné, Julien, primary, Cauchois, Aurélie, primary, Le Boulch, Marie, primary, Poupon, Clotilde, primary, Henno, Sébastien, primary, Rioux-Leclercq, Nathalie, primary, Le Pabic, Estelle, primary, Laviolle, Bruno, primary, Catros, Véronique, primary, Levêque, Jean, primary, Fautrel, Alain, primary, Le Gallo, Matthieu, primary, Legembre, Patrick, primary, and Lavoué, Vincent, primary

Published
2023
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84. Data from Serum CD95L Level Correlates with Tumor Immune Infiltration and Is a Positive Prognostic Marker for Advanced High-Grade Serous Ovarian Cancer

Author

De La Motte Rouge, Thibault, primary, Corné, Julien, primary, Cauchois, Aurélie, primary, Le Boulch, Marie, primary, Poupon, Clotilde, primary, Henno, Sébastien, primary, Rioux-Leclercq, Nathalie, primary, Le Pabic, Estelle, primary, Laviolle, Bruno, primary, Catros, Véronique, primary, Levêque, Jean, primary, Fautrel, Alain, primary, Le Gallo, Matthieu, primary, Legembre, Patrick, primary, and Lavoué, Vincent, primary

Published
2023
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85. Supplementary Table 1 from Serum CD95L Level Correlates with Tumor Immune Infiltration and Is a Positive Prognostic Marker for Advanced High-Grade Serous Ovarian Cancer

Author

De La Motte Rouge, Thibault, primary, Corné, Julien, primary, Cauchois, Aurélie, primary, Le Boulch, Marie, primary, Poupon, Clotilde, primary, Henno, Sébastien, primary, Rioux-Leclercq, Nathalie, primary, Le Pabic, Estelle, primary, Laviolle, Bruno, primary, Catros, Véronique, primary, Levêque, Jean, primary, Fautrel, Alain, primary, Le Gallo, Matthieu, primary, Legembre, Patrick, primary, and Lavoué, Vincent, primary

Published
2023
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87. Fetal Description of the Pancreatic Agenesis and Holoprosencephaly Syndrome Associated to a Specific CNOT1 Variant

Author

Auriane Cospain, Marie Faoucher, Aurélie Cauchois, Wilfrid Carre, Chloé Quelin, Christèle Dubourg, CHU Pontchaillou [Rennes], Centre de référence Maladies Rares CLAD-Ouest [Rennes], Institut de Génétique et Développement de Rennes (IGDR), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
musculoskeletal diseases, hypoplasia, [SDV.GEN]Life Sciences [q-bio]/Genetics, holoprosencephaly, fetal autopsy, congenital malformation, Pediatrics, Perinatology and Child Health, CNOT1, General Medicine, pancreas agenesis, post-mortem examination, Pathology and Forensic Medicine
Abstract

International audience; Holoprosencephaly (HPE) is a clinically and genetically heterogeneous disease, which can be associated with various prenatal comorbidities not always detectable on prenatal ultrasound. We report on the case of a foetus carrying a semi-lobar HPE diagnosed at ultrasound, for which a fetal autopsy and a whole exome sequencing were performed following a medical termination of pregnancy. Neuropathological examination confirmed the semi-lobar HPE and general autopsy disclosed a total pancreas agenesis. Whole exome sequencing found the CNOT1 missense c.1603C>T, p.(Arg535Cys), occurring de novo in the foetus. The same variant was previously reported in 5 unrelated children. All individuals had HPE, and 4 out of 5 presented endo- and exocrine pancreatic insufficiency or total pancreas agenesis. CNOT1 encodes a subunit of the CCRN4-NOT complex, expressed at the early stage of embryonic development. This report is the first fetal description of the phenotype associating HPE and pancreatic agenesis linked to the recurrent CNOT1 missense c.1603C>T, p.(Arg535Cys). This finding strengthens the hypothesis of a specific recurrent variant associated with a particular phenotype of HPE and pancreas agenesis. The fetal autopsy that revealed the pancreas agenesis was crucial in guiding the genetic diagnosis and enabling accurate genetic counselling.

Published
2022
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88. Tocilizumab versus anakinra in COVID-19: results from propensity score matching

Author

Robin Arcani, Florian Correard, Pierre Suchon, Gilles Kaplanski, Rodolphe Jean, Raphael Cauchois, Marine Leprince, Vincent Arcani, Julie Seguier, Benjamin De Sainte Marie, Baptiste Andre, Marie Koubi, Pascal Rossi, Stéphane Gayet, Nirvina Gobin, Victoria Garrido, Joris Weiland, Elisabeth Jouve, Anne-Laure Couderc, Patrick Villani, and Aurélie Daumas

Subjects
Immunology, Immunology and Allergy
Abstract

BackgroundTocilizumab and anakinra are anti-interleukin drugs to treat severe coronavirus disease 2019 (COVID-19) refractory to corticosteroids. However, no studies compared the efficacy of tocilizumab versus anakinra to guide the choice of the therapy in clinical practice. We aimed to compare the outcomes of COVID-19 patients treated with tocilizumab or anakinra.MethodsOur retrospective study was conducted in three French university hospitals between February 2021 and February 2022 and included all the consecutive hospitalized patients with a laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection assessed by RT-PCR who were treated with tocilizumab or anakinra. A propensity score matching was performed to minimize confounding effects due to the non-random allocation.ResultsAmong 235 patients (mean age, 72 years; 60.9% of male patients), the 28-day mortality (29.4% vs. 31.2%, p = 0.76), the in-hospital mortality (31.7% vs. 33.0%, p = 0.83), the high-flow oxygen requirement (17.5% vs. 18.3%, p = 0.86), the intensive care unit admission rate (30.8% vs. 22.2%, p = 0.30), and the mechanical ventilation rate (15.4% vs. 11.1%, p = 0.50) were similar in patients receiving tocilizumab and those receiving anakinra. After propensity score matching, the 28-day mortality (29.1% vs. 30.4%, p = 1) and the rate of high-flow oxygen requirement (10.1% vs. 21.5%, p = 0.081) did not differ between patients receiving tocilizumab or anakinra. Secondary infection rates were similar between the tocilizumab and anakinra groups (6.3% vs. 9.2%, p = 0.44).ConclusionOur study showed comparable efficacy and safety profiles of tocilizumab and anakinra to treat severe COVID-19.

Published
2023
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89. Ambulatory electrocardiographic longitudinal monitoring in dystrophin-deficient dogs identifies decreased Very Low Frequency power as a hallmark of impaired Heart Rate Variability in Duchenne Muscular Dystrophy

Author

Inès Barthélémy, Jin Bo Su, Xavier Cauchois, Frédéric Relaix, Bijan Ghaleh, and Stéphane Blot

Abstract

BackgroundDuchenne muscular dystrophy (DMD) patients exhibit a late left ventricular systolic dysfunction preceded by an occult phase, during which myocardial fibrosis progresses and some early functional impairments can be detected. These latter include electrocardiographic (ECG) and heart rate variability (HRV) abnormalities.MethodsA longitudinal study aiming at describing the sequence of ECG and HRV abnormalities, relative to cardiac function degradation, using Holter ECG, was performed in the GRMD (Golden retriever muscular dystrophy) dog model, known to develop a DMD-like disease, including cardiomyopathy.ResultsMost of the known ECG and HRV abnormalities described in DMD patients were also found in GRMD dogs, and several of them could be detected months before the decrease of fractional shortening. One of the earliest evidenced abnormalities was a decrease in the very low frequency (VLF) component of the power spectrum, and this decrease was correlated with the further reduction of fractional shortening. Such decreased VLF probably reflects impaired autonomic function and abnormal vasomotor tone.ConclusionThis study provides new insights into the knowledge of the GRMD dog model and DMD cardiomyopathy and emphasizes the interest to monitor the VLF power in DMD patients, still unexplored in this disease, whilst it is highly predictive of deleterious clinical events in many other pathological conditions.AbbreviationscTpnICardiac Troponin IDMDDuchenne Muscular DystrophyECGElectrocardiogramGRMDGolden Retriever Muscular DystrophyHFHigh FrequencyHRHeart RateHRVHeart Rate VariabilityLFLow FrequencyLGELate Gadolinium EnhancementLTVLong-Term VariabilityLVEFLeft Ventricular Ejection FractionNT-proBNPN-Terminal part of the pro-Brain Natriuretic PeptidepNN50percentage of interval differences of successive RR intervals of more than 50 mspNN10 %(meanRR)percentage of interval differences of successive RR intervals of more than 10% of the mean RRQTccorrected QT intervalRMSSDsquare root of the mean squared differences of successive RR intervalsSDNNStandard Deviation of the RR intervalsLVFSLeft Ventricular Fractional ShorteningSTVShort-Term VariabilityVLFVery Low FrequencyPVBPremature Ventricular BeatVTVentricular Tachycardia.

Published
2023
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90. Modeling of the driver transverse profile for laser wakefield electron acceleration at APOLLON research facility

Author

I. Moulanier, L. T. Dickson, C. Ballage, O. Vasilovici, A. Gremaud, S. Dobosz Dufrénoy, N. Delerue, L. Bernardi, A. Mahjoub, A. Cauchois, A. Specka, F. Massimo, G. Maynard, B. Cros, Laboratoire de physique des gaz et des plasmas (LPGP), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interactions, Dynamiques et Lasers (ex SPAM) (LIDyl), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), and ANR-10-EQPX-0025,CILEX,Centre Interdisciplinaire Lumière Extrême(2010)

Subjects
[PHYS]Physics [physics], Plasma Physics (physics.plasm-ph), Accelerator Physics (physics.acc-ph), particle in cell simulations, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], FOS: Physical sciences, Laser wakefield acceleration, Physics - Accelerator Physics, Condensed Matter Physics, High intensity laser-plasma interactions, Physics - Plasma Physics
Abstract

International audience; The quality of electron bunches accelerated by laser wakefields is highly dependant on the temporal and spatial features of the laser driver. Analysis of experiments performed at APOLLON PW-class laser facility shows that spatial instabilities of the focal spot, such as shot-to-shot pointing fluctuations or asymmetry of the transverse fluence, lead to charge and energy degradation of the accelerated electron bunch. It is shown that PIC simulations can reproduce experimental results with a significantly higher accuracy when the measured laser asymmetries are included in the simulated laser's transverse profile, compared to simulations with ideal, symmetric laser profile. A method based on a modified Gerchberg-Saxton iterative algorithm is used to retrieve the laser electric field from fluence measurements in vacuum in the focal volume, and accurately reproduce experimental results using PIC simulations, leading to simulated electron spectra in close agreement with experimental results, for the accelerated charge, energy distribution and pointing of the electron beam at the exit of the plasma.

Published
2023
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91. Supplementary Figure from A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota

Author

Bertrand Routy, Bastien Castagner, André Marette, Arielle Elkrief, Guido Kroemer, Sylvere Durand, Emmanuelle Le Chatelier, Oscar Gitton-Quent, Florian Plaza Oñate, Geneviève Pilon, Emilia Liana Falcone, Yves V. Brun, David T. Kysela, Sandy Chevrier, Romain Boidot, François Ghiringhelli, Didier Raoult, Paul Oster, Dominique Velin, Lharbi Dridi, Yves Fradet, Stephane Isnard, Wiam Belkaid, Julie Malo, Florent Cauchois, Alexis Nolin-Lapalme, Myriam Benlaifaoui, Khoudia Diop, Mayra Ponce, Corentin Richard, Reilly Pidgeon, and Meriem Messaoudene

Abstract

Supplementary Figure from A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota

Published
2023
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92. Data from A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota

Author

Bertrand Routy, Bastien Castagner, André Marette, Arielle Elkrief, Guido Kroemer, Sylvere Durand, Emmanuelle Le Chatelier, Oscar Gitton-Quent, Florian Plaza Oñate, Geneviève Pilon, Emilia Liana Falcone, Yves V. Brun, David T. Kysela, Sandy Chevrier, Romain Boidot, François Ghiringhelli, Didier Raoult, Paul Oster, Dominique Velin, Lharbi Dridi, Yves Fradet, Stephane Isnard, Wiam Belkaid, Julie Malo, Florent Cauchois, Alexis Nolin-Lapalme, Myriam Benlaifaoui, Khoudia Diop, Mayra Ponce, Corentin Richard, Reilly Pidgeon, and Meriem Messaoudene

Abstract

Several approaches to manipulate the gut microbiome for improving the activity of cancer immune-checkpoint inhibitors (ICI) are currently under evaluation. Here, we show that oral supplementation with the polyphenol-rich berry camu-camu (CC; Myrciaria dubia) in mice shifted gut microbial composition, which translated into antitumor activity and a stronger anti–PD-1 response. We identified castalagin, an ellagitannin, as the active compound in CC. Oral administration of castalagin enriched for bacteria associated with efficient immunotherapeutic responses (Ruminococcaceae and Alistipes) and improved the CD8+/FOXP3+CD4+ ratio within the tumor microenvironment. Moreover, castalagin induced metabolic changes, resulting in an increase in taurine-conjugated bile acids. Oral supplementation of castalagin following fecal microbiota transplantation from ICI-refractory patients into mice supported anti–PD-1 activity. Finally, we found that castalagin binds to Ruminococcus bromii and promoted an anticancer response. Altogether, our results identify castalagin as a polyphenol that acts as a prebiotic to circumvent anti–PD-1 resistance.Significance:The polyphenol castalagin isolated from a berry has an antitumor effect through direct interactions with commensal bacteria, thus reprogramming the tumor microenvironment. In addition, in preclinical ICI-resistant models, castalagin reestablishes the efficacy of anti–PD-1. Together, these results provide a strong biological rationale to test castalagin as part of a clinical trial.This article is highlighted in the In This Issue feature, p. 873

Published
2023
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93. Data from Serum CD95L Level Correlates with Tumor Immune Infiltration and Is a Positive Prognostic Marker for Advanced High-Grade Serous Ovarian Cancer

Author

Vincent Lavoué, Patrick Legembre, Matthieu Le Gallo, Alain Fautrel, Jean Levêque, Véronique Catros, Bruno Laviolle, Estelle Le Pabic, Nathalie Rioux-Leclercq, Sébastien Henno, Clotilde Poupon, Marie Le Boulch, Aurélie Cauchois, Julien Corné, and Thibault De La Motte Rouge

Abstract

Soluble CD95L (s-CD95L) is a chemoattractant for certain lymphocyte subpopulations. We examined whether this ligand is a prognostic marker for high-grade serous ovarian cancer (HGSOC) and whether it is associated with accumulation of immune cells in the tumor. Serum s-CD95L levels in 51 patients with advanced ovarian cancer were tested by ELISA. IHC staining of CD3, CD4, CD8, CD20, CD163, CD31, FoxP3, CCR6, IL-17, Granzyme B, PD-L1, and membrane CD95L was used to assess tumor-infiltrating immune cells. Although the intensity of CD3, CD8, CD4, CD20, and CD163 in tumor tissues remained constant regardless of membrane CD95L expression, tumors in patients with HGSOC with s-CD95L levels ≥516 pg/mL showed increased infiltration by CD3+ T cells (P = 0.001), comprising both cytotoxic CD8+ (P = 0.01) and CD4+ (P = 0.0062) cells including FoxP3+ regulatory T cells (P = 0.0044). Also, the number of tumor-infiltrating CD20+ B cells (P = 0.0094) increased in these patients. Multivariate analyses revealed that low s-CD95L concentrations [+ (Granzyme B+) cells (HR, 2.63; 95% CI, 1.16–5.95) were independent poor prognostic factors for recurrence, whereas >6,000 CD3+ cells (HR, 0.34; 95% CI, 0.15–0.79) was a good prognostic factor. Thus, low levels of s-CD95L (+ and CD8+, and also CD4 and FoxP3 T cells) in advanced HGSOC and are a poor prognostic marker.Implications:Serum s-CD95L is correlated with a number of tumor-infiltrating immune cells in HGSOC and could be used as a noninvasive marker of tumor immune infiltration to select patients referred for immunotherapy trials that evaluate checkpoint inhibitor treatment.

Published
2023
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94. Supplementary Table 1 from Serum CD95L Level Correlates with Tumor Immune Infiltration and Is a Positive Prognostic Marker for Advanced High-Grade Serous Ovarian Cancer

Author

Vincent Lavoué, Patrick Legembre, Matthieu Le Gallo, Alain Fautrel, Jean Levêque, Véronique Catros, Bruno Laviolle, Estelle Le Pabic, Nathalie Rioux-Leclercq, Sébastien Henno, Clotilde Poupon, Marie Le Boulch, Aurélie Cauchois, Julien Corné, and Thibault De La Motte Rouge

Abstract

Table S1. Clinical characteristics of the patients

Published
2023
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95. Supplementary Data, Figure 1 from Serum CD95L Level Correlates with Tumor Immune Infiltration and Is a Positive Prognostic Marker for Advanced High-Grade Serous Ovarian Cancer

Author

Vincent Lavoué, Patrick Legembre, Matthieu Le Gallo, Alain Fautrel, Jean Levêque, Véronique Catros, Bruno Laviolle, Estelle Le Pabic, Nathalie Rioux-Leclercq, Sébastien Henno, Clotilde Poupon, Marie Le Boulch, Aurélie Cauchois, Julien Corné, and Thibault De La Motte Rouge

Abstract

Figure 1A: Membranous CD95 expression on ovarian cancer cell lines and primary cancer cells by cytometry Figure 1B: Evaluation of epithelial mesenchymal transition expression (EMT) profile using vimentin and E-cadherin expression on ovarian cancer cell line and primary cancer cells by Western Blot (A). Vimentin and E-cadherin expression ratio mean on ovarian cancer cells based on 3 experiments (B). Figure 1C: ALDH1 activity with or without s-CD95L (100 ng/mL) evaluated by cytometry. Figure 1D: Proliferation of OVCAR3 cell lines using cytometry and G1, G2 and S phase markers E: Proliferation of O170 primary cell lines using cytometry and G1, G2 and S phase markers F: Proliferation of various ovarian cancer cell lines or primary cell lines with or without s-CD95L (100 ng/mL) in medium using cytometry and G1, G2 and S phase markers

Published
2023
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99. Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

Author

Evdoxia Kyriazopoulou, Thomas Huet, Giulio Cavalli, Andrea Gori, Miltiades Kyprianou, Peter Pickkers, Jesper Eugen-Olsen, Mario Clerici, Francisco Veas, Gilles Chatellier, Gilles Kaplanski, Mihai G Netea, Emanuele Pontali, Marco Gattorno, Raphael Cauchois, Emma Kooistra, Matthijs Kox, Alessandra Bandera, Hélène Beaussier, Davide Mangioni, Lorenzo Dagna, Jos W M van der Meer, Evangelos J Giamarellos-Bourboulis, Gilles Hayem, Mihai G. Netea, Jos W.M. van der Meer, Evangelos J. Giamarellos-Bourboulis, Stefano Volpi, Maria Pia Sormani, Alessio Signori, Giorgio Bozzi, Francesca Minoia, Stefano Aliberti, Giacomo Grasselli, Laura Alagna, Andrea Lombardi, Riccardo Ungaro, Carlo Agostoni, Francesco Blasi, Giorgio Costantino, Anna Ludovica Fracanzani, Nicola Montano, Flora Peyvandi, Marcello Sottocorno, Antonio Muscatello, Giovanni Filocamo, Antonios Papadopoulos, Maria Mouktaroudi, Eleni Karakike, Maria Saridaki, Theologia Gkavogianni, Konstantina Katrini, Nikolaos Vechlidis, Christina Avgoustou, Stamatios Chalvatzis, Theodoros Marantos, Christina Damoulari, Georgia Damoraki, Sofia Ktena, Maria Tsilika, Panagiotis Koufargyris, Athanasios Karageorgos, Dionysia-Irene Droggiti, Aikaterini Koliakou, Garyfallia Poulakou, Konstantinos Tsiakos, Dimitra-Melia Myrodia, Areti Gravvani, Ioannis P. Trontzas, Konstantinos Syrigos, Ioannis Kalomenidis, Eleftheria Kranidioti, Periklis Panagopoulos, Vasileios Petrakis, Simeon Metallidis, Georgia Loli, Olga Tsachouridou, George N. Dalekos, Nikolaos Gatselis, Aggelos Stefos, Sarah Georgiadou, Vassiliki Lygoura, Haralampos Milionis, Maria Kosmidou, Ilias C. Papanikolaou, Karolina Akinosoglou, Efthymia Giannitsioti, Georgios Chrysos, Panagiotis Mavroudis, Chrysanthi Sidiropoulou, Georgios Adamis, Archontoula Fragkou, Aggeliki Rapti, Zoi Alexiou, Styliani Symbardi, Aikaterini Masgala, Konstantina Kostaki, Evangelos Kostis, Michael Samarkos, Petros Bakakos, Vassiliki Tzavara, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Vasileios Kotsis, George Tsoukalas, Ioannis Bliziotis, Michael Doumas, Aikaterini Argyraki, Ilias Kainis, Massimo Fantoni, Antonella Cingolani, Andrea Angheben, Chiara Simona Cardellino, Francesco Castelli, Francesco Saverio Serino, Emanuele Nicastri, Giuseppe Ippolito, Matteo Bassetti, Carlo Selmi, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Kyriazopoulou, E., Huet, T., Cavalli, Giulio., Gori, A., Kyprianou, M., Pickkers, P., Eugen-Olsen, J., Clerici, M., Veas, F., Chatellier, G., Kaplanski, G., Netea, M. G., Pontali, E., Gattorno, M., Cauchois, R., Kooistra, E., Kox, M., Bandera, A., Beaussier, H., Mangioni, D., Dagna, L., van der Meer, J. W. M., Giamarellos-Bourboulis, E. J., Hayem, G., Volpi, S., Sormani, M. P., Signori, A., Bozzi, G., Minoia, F., Aliberti, S., Grasselli, G., Alagna, L., Lombardi, A., Ungaro, R., Agostoni, C., Blasi, F., Costantino, G., Fracanzani, A. L., Montano, N., Peyvandi, F., Sottocorno, M., Muscatello, A., Filocamo, G., Papadopoulos, A., Mouktaroudi, M., Karakike, E., Saridaki, M., Gkavogianni, T., Katrini, K., Vechlidis, N., Avgoustou, C., Chalvatzis, S., Marantos, T., Damoulari, C., Damoraki, G., Ktena, S., Tsilika, M., Koufargyris, P., Karageorgos, A., Droggiti, D. -I., Koliakou, A., Poulakou, G., Tsiakos, K., Myrodia, D. -M., Gravvani, A., Trontzas, I. P., Syrigos, K., Kalomenidis, I., Kranidioti, E., Panagopoulos, P., Petrakis, V., Metallidis, S., Loli, G., Tsachouridou, O., Dalekos, G. N., Gatselis, N., Stefos, A., Georgiadou, S., Lygoura, V., Milionis, H., Kosmidou, M., Papanikolaou, I. C., Akinosoglou, K., Giannitsioti, E., Chrysos, G., Mavroudis, P., Sidiropoulou, C., Adamis, G., Fragkou, A., Rapti, A., Alexiou, Z., Symbardi, S., Masgala, A., Kostaki, K., Kostis, E., Samarkos, M., Bakakos, P., Tzavara, V., Dimakou, K., Tzatzagou, G., Chini, M., Kotsis, V., Tsoukalas, G., Bliziotis, I., Doumas, M., Argyraki, A., Kainis, I., Fantoni, M., Cingolani, A., Angheben, A., Cardellino, C. S., Castelli, F., Serino, F. S., Nicastri, E., Ippolito, G., Bassetti, M., and Selmi, C.

Subjects
medicine.medical_specialty, Anakinra, business.industry, Secondary infection, [SDV]Life Sciences [q-bio], Immunology, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Odds ratio, Articles, Placebo, law.invention, Rheumatology, Randomized controlled trial, law, Meta-analysis, Fraction of inspired oxygen, Internal medicine, Clinical endpoint, Immunology and Allergy, Medicine, business, ComputingMilieux_MISCELLANEOUS, medicine.drug
Abstract

Contains fulltext : 237989.pdf (Publisher’s version ) (Closed access) BACKGROUND: Anakinra might improve the prognosis of patients with moderate to severe COVID-19 (ie, patients requiring oxygen supplementation but not yet receiving organ support). We aimed to assess the effect of anakinra treatment on mortality in patients admitted to hospital with COVID-19. METHODS: For this systematic review and individual patient-level meta-analysis, a systematic literature search was done on Dec 28, 2020, in Medline (PubMed), Cochrane, medRxiv, bioRxiv, and the ClinicalTrials.gov databases for randomised trials, comparative studies, and observational studies of patients admitted to hospital with COVID-19, comparing administration of anakinra with standard of care, or placebo, or both. The search was repeated on Jan 22, 2021. Individual patient-level data were requested from investigators and corresponding authors of eligible studies; if individual patient-level data were not available, published data were extracted from the original reports. The primary endpoint was mortality after 28 days and the secondary endpoint was safety (eg, the risk of secondary infections). This study is registered on PROSPERO (CRD42020221491). FINDINGS: 209 articles were identified, of which 178 full-text articles fulfilled screening criteria and were assessed. Aggregate data on 1185 patients from nine studies were analysed, and individual patient-level data on 895 patients were provided from six of these studies. Eight studies were observational and one was a randomised controlled trial. Most studies used historical controls. In the individual patient-level meta-analysis, after adjusting for age, comorbidities, baseline ratio of the arterial partial oxygen pressure divided by the fraction of inspired oxygen (PaO(2)/FiO(2)), C-reactive protein (CRP) concentrations, and lymphopenia, mortality was significantly lower in patients treated with anakinra (38 [11%] of 342) than in those receiving standard of care with or without placebo (137 [25%] of 553; adjusted odds ratio [OR] 0·32 [95% CI 0·20-0·51]). The mortality benefit was similar across subgroups regardless of comorbidities (ie, diabetes), ferritin concentrations, or the baseline PaO(2)/FiO(2). In a subgroup analysis, anakinra was more effective in lowering mortality in patients with CRP concentrations higher than 100 mg/L (OR 0·28 [95% CI 0·17-0·47]). Anakinra showed a significant survival benefit when given without dexamethasone (OR 0·23 [95% CI 0·12-0·43]), but not with dexamethasone co-administration (0·72 [95% CI 0·37-1·41]). Anakinra was not associated with a significantly increased risk of secondary infections when compared with standard of care (OR 1·35 [95% CI 0·59-3·10]). INTERPRETATION: Anakinra could be a safe, anti-inflammatory treatment option to reduce the mortality risk in patients admitted to hospital with moderate to severe COVID-19 pneumonia, especially in the presence of signs of hyperinflammation such as CRP concentrations higher than 100 mg/L. FUNDING: Sobi.

Published
2021
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