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51. ELECTROCARDIOGRAPHIC FINDINGS IN PATIENTS WITH DEMENTIA

Author

Sabrina Realmuto, Antonino Tuttolomondo, Cupidi, C., Serio, A., Valentina Arnao, Sta, L., Cerami, C., Lo Re, V., Navarra, V., Antonio Pinto, Licata, G., Piccoli, F., Tommaso Piccoli, S REALMUTO, A TUTTOLOMONDO, C CUPIDI, A SERIO, V ARNAO, STA LAMANCA, C CERAMI, V LO RE, V NAVARRA, A PINTO, G LICATA, PICCOLI F, and T PICCOLI

Subjects
ECG AD
Published
2008

52. Evaluation of an optimized [18F]fluoro-deoxy-glucose positron emission tomography voxel-wise method to early support differential diagnosis in atypical Parkinsonian disorders.

Author

Caminiti, S. P., Alongi, P., Majno, L., Volontè, M. A., Cerami, C., Gianolli, L., Comi, G., and Perani, D.

Subjects
PARKINSON'S disease diagnosis, POSITRON emission tomography, DIFFERENTIAL diagnosis, DEMENTIA, LEWY body dementia
Abstract

Background and purpose Atypical Parkinsonian disorders ( APD) frequently overlap in clinical presentations, making the differential diagnosis challenging in the early stages. The present study aimed to evaluate the accuracy of the [18F]fluoro-deoxy-glucose positron emission tomography Statistical Parametric Mapping ( SPM) optimized procedure in supporting the early and differential diagnosis of APD. Methods Seventy patients with possible APD were retrospectively included from a large clinical cohort. The included patients underwent [18F]fluoro-deoxy-glucose positron emission tomography within 3 months of the first clinical assessment and a diagnostic follow-up. An optimized SPM voxel-wise procedure was used to produce t-maps of brain hypometabolism in single subjects, which were classified by experts blinded to any clinical information. We compared the accuracy of both the first clinical diagnosis and the SPM t-map classifications with the diagnosis at follow-up as the reference standard. Results At first diagnosis , 60% of patients were classified as possible APD (progressive supranuclear palsy, corticobasal degeneration, dementia with Lewy bodies, multiple system atrophy) and about 40% as APD with uncertain diagnosis, providing 52% sensitivity, 97% specificity and 86% accuracy with respect to the reference standard. SPM t-map classification showed 98% sensitivity, 99% specificity and 99% accuracy, and a significant agreement with the diagnosis at follow-up ( P < 0.001). Conclusions The SPM t-map classification at entry predicted the second diagnosis at follow-up. This indicates its significantly superior role for an early identification of APD subtypes, particularly in cases of uncertain diagnosis. The use of a metabolic biomarker at entry in the instrumental work-up of APD may shorten the diagnostic time, producing benefits for treatment options and support to the patients. [ABSTRACT FROM AUTHOR]

Published
2017
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53. A Standardized [18F]-FDG-PET Template for Spatial Normalization in Statistical Parametric Mapping of Dementia

Author

Della Rosa, P, Cerami, C, Gallivanone, F, Prestia, A, Caroli, A, Castiglioni, I, Gilardi, M, Frisoni, G, Friston, K, Ashburner, J, Perani, D, Perani, D., GILARDI, MARIA CARLA, Della Rosa, P, Cerami, C, Gallivanone, F, Prestia, A, Caroli, A, Castiglioni, I, Gilardi, M, Frisoni, G, Friston, K, Ashburner, J, Perani, D, Perani, D., and GILARDI, MARIA CARLA

Abstract

[18F]-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) is a widely used diagnostic tool that can detect and quantify pathophysiology, as assessed through changes in cerebral glucose metabolism. [18F]-FDG PET scans can be analyzed using voxel-based statistical methods such as Statistical Parametric Mapping (SPM) that provide statistical maps of brain abnormalities in single patients. In order to perform SPM, a “spatial normalization” of an individual’s PET scan is required to match a reference PET template. The PET template currently used for SPM normalization is based on [15O]-H2O images and does not resemble either the specific metabolic features of [18F]-FDG brain scans or the specific morphological characteristics of individual brains affected by neurodegeneration. Thus, our aim was to create a new [18F]-FDG PET aging and dementia-specific template for spatial normalization, based on images derived from both age-matched controls and patients. We hypothesized that this template would increase spatial normalization accuracy and thereby preserve crucial information for research and diagnostic purposes. We investigated the statistical sensitivity and registration accuracy of normalization procedures based on the standard and new template—at the single-subject and group level—independently for subjects with Mild Cognitive Impairment (MCI), probable Alzheimer’s Disease (AD), Frontotemporal lobar degeneration (FTLD) and dementia with Lewy bodies (DLB). We found a significant statistical effect of the population-specific FDG template-based normalisation in key anatomical regions for each dementia subtype, suggesting that spatial normalization with the new template provides more accurate estimates of metabolic abnormalities for single-subject and group analysis, and therefore, a more effective diagnostic measure.

Published
2014

55. In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease

Author

Iannaccone, S, Cerami, C, Alessio, M, Garibotto, V, Panzacchi, A, Olivieri, S, Gelsomino, G, Moresco, R, Perani, D, Perani, D., MORESCO, ROSA MARIA, Iannaccone, S, Cerami, C, Alessio, M, Garibotto, V, Panzacchi, A, Olivieri, S, Gelsomino, G, Moresco, R, Perani, D, Perani, D., and MORESCO, ROSA MARIA

Abstract

BACKGROUND: Reactive microgliosis, hallmark of neuroinflammation, may contribute to neuronal degeneration, as shown in several neurodegenerative diseases. We in vivo evaluated microglia activation in early dementia with Lewy bodies, still not reported, and compared with early Parkinson's disease, to assess possible differential pathological patterns. METHODS: We measured the [(11)C]-PK11195 binding potentials with Positron Emission Tomography, using a simplified reference tissue model, as marker of microglia activation, and cerebral spinal fluid protein carbonylation levels, as marker of oxidative stress. Six dementia with Lewy bodies and 6 Parkinson's disease patients within a year from the onset, and eleven healthy controls were included. Clinical diagnosis was confirmed at a 4-year follow-up. RESULTS: In dementia with Lewy bodies as well as in Parkinson's disease, we found significant (p < 0.001) [(11)C]-PK11195 binding potential increases in the substantia nigra and putamen. Patients with Lewy bodies dementia had extensive additional microglia activation in several associative cortices. This was evident also at a single subject level. Significant increase of Cerebral Spinal Fluid protein carbonylation was shown in both patients' groups. CONCLUSIONS: [(11)C]-PK11195 Positron Emission Tomography imaging revealed neuroinflammation in dementia with Lewy bodies and Parkinson's disease, mirroring, even at a single subject level, the common and the different topographical distribution of neuropathological changes, yet in the earliest stages of the disease process. Focusing on those events that characterize parkinsonisms and Parkinson's disease may be the key to further advancing the understanding of pathogenesis and to taking these mechanisms forward as a means of defining targets for neuroprotection.

Published
2013

56. Autosomal dominant frontotemporal lobar degeneration due to the C9ORF72 hexanucleotide repeat expansion: late-onset psychotic clinical presentation

Author

Galimberti, D, Fenoglio, C, Serpente, M, Villa, C, Bonsi, R, Arighi, A, Fumagalli, G, Del Bo, R, Bruni, A, Anfossi, M, Clodomiro, A, Cupidi, C, Nacmias, B, Sorbi, S, Piaceri, I, Bagnoli, S, Bessi, V, Marcone, A, Cerami, C, Cappa, S, Filippi, M, Agosta, F, Magnani, G, Comi, G, Franceschi, M, Rainero, I, Giordana, M, Rubino, E, Ferrero, P, Rogaeva, E, Xi, Z, Confaloni, A, Piscopo, P, Bruno, G, Talarico, G, Cagnin, A, Clerici, F, Dell'Osso, B, Altamura, A, Mariani, C, Scarpini, E, Fumagalli, GG, Bruni, AC, Cappa, SF, Giordana, MT, Comi, GP, Altamura, AC, Scarpini, E., VILLA, CHIARA, Galimberti, D, Fenoglio, C, Serpente, M, Villa, C, Bonsi, R, Arighi, A, Fumagalli, G, Del Bo, R, Bruni, A, Anfossi, M, Clodomiro, A, Cupidi, C, Nacmias, B, Sorbi, S, Piaceri, I, Bagnoli, S, Bessi, V, Marcone, A, Cerami, C, Cappa, S, Filippi, M, Agosta, F, Magnani, G, Comi, G, Franceschi, M, Rainero, I, Giordana, M, Rubino, E, Ferrero, P, Rogaeva, E, Xi, Z, Confaloni, A, Piscopo, P, Bruno, G, Talarico, G, Cagnin, A, Clerici, F, Dell'Osso, B, Altamura, A, Mariani, C, Scarpini, E, Fumagalli, GG, Bruni, AC, Cappa, SF, Giordana, MT, Comi, GP, Altamura, AC, Scarpini, E., and VILLA, CHIARA

Abstract

Background: A hexanucleotide repeat expansion in the first intron of C9ORF72 has been shown to be responsible for a high number of familial cases of amyotrophic lateral sclerosis or frontotemporal lobar degeneration (FTLD). Atypical presentations have been described, particularly psychosis. Methods: We determined the frequency of the hexanucleotide repeat expansions in a population of 651 FTLD patients and compared the clinical characteristics of carriers and noncarriers. In addition, we genotyped 21 patients with corticobasal syndrome, 31 patients with progressive supranuclear palsy, and 222 control subjects. Results: The pathogenic repeat expansion was detected in 39 (6%) patients with FTLD (17 male and 22 female subjects); however, it was not detected in any corticobasal syndrome and progressive supranuclear palsy patients or controls. Twenty-four of 39 carriers had positive family history for dementia and/or amyotrophic lateral sclerosis (61.5%), whereas only 145 of 612 noncarriers had positive family history (23.7%; p<.000001). Clinical phenotypes of carriers included 29 patients with the behavioral variant frontotemporal dementia (bvFTD; 5.2% of all bvFTD cases), 8 with bvFTD/motor neuron disease (32% bvFTD/motor neuron disease cases), 2 with semantic dementia (5.9% of patients with semantic dementia), and none with progressive nonfluent aphasia. The presentation with late-onset psychosis (median age = 63 years) was more frequent in carriers than noncarriers (10/33 vs. 3/37, p =.029), as well as the presence of cognitive impairment at onset (15/33 vs. 5/37; p =.0039). Conclusions: The repeat expansion in C9ORF72 is a common cause of FTLD and often presents with late-onset psychosis or memory impairment. © 2013 Society of Biological Psychiatry.

Published
2013

57. Novel missense progranulin gene mutation associated with the semantic variant of primary progressive aphasia

Author

Cerami, C, Marcone, A, Galimberti, D, Villa, C, Fenoglio, C, Scarpini, E, Cappa, S, VILLA, CHIARA, Cappa, SF, Cerami, C, Marcone, A, Galimberti, D, Villa, C, Fenoglio, C, Scarpini, E, Cappa, S, VILLA, CHIARA, and Cappa, SF

Abstract

Progranulin (GRN) mutations are typically associated with the behavioral variant of frontotemporal dementia and the non-fluent variant of primary progressive aphasia phenotypes. Hereby, we describe a patient affected by semantic variant of primary progressive aphasia (svPPA) with a highly positive family history of dementia, carrying a novel GRN missense variation in exon 11 [g.2897 C > T (p.Thr409Met)], predicted in silico to be damaging to protein structure and function. The variant was absent in 175 frontotemporal lobar degeneration (FTLD) patients and in 38 healthy subjects. This case confirms that GRN represents one of the most frequent FTLD genetic causes, suggesting that a screening is indicated in the case of svPPA presentation. © 2013 - IOS Press and the authors. All rights reserved.

Published
2013

58. Genetics and expression analysis of the specificity protein 4 gene (SP4) in patients with Alzheimer's disease and frontotemporal lobar degeneration

Author

Villa, C, Ghezzi, L, Fenoglio, C, Clerici, F, Marcone, A, Benussi, L, Ghidoni, R, Gallone, S, Serpente, M, Cantoni, C, Ridolfi, E, Bonsi, R, Cerami, C, Cappa, S, Binetti, G, Franceschi, M, Rainero, I, Mariani, C, Bresolin, N, Scarpini, E, Galimberti, D, VILLA, CHIARA, Galimberti, D., Villa, C, Ghezzi, L, Fenoglio, C, Clerici, F, Marcone, A, Benussi, L, Ghidoni, R, Gallone, S, Serpente, M, Cantoni, C, Ridolfi, E, Bonsi, R, Cerami, C, Cappa, S, Binetti, G, Franceschi, M, Rainero, I, Mariani, C, Bresolin, N, Scarpini, E, Galimberti, D, VILLA, CHIARA, and Galimberti, D.

Abstract

Transcription factor Sp4 (Specificity protein 4) levels are increased in the brain of patients with Alzheimer's disease (AD), and Sp4 colocalizes with neurofibrillary tangles. Moreover, SP4 is a susceptibility gene for bipolar disorder and schizophrenia, which share many clinical features with frontotemporal lobar degeneration (FTLD). The distribution of three tagging single nucleotide polymorphisms (SNPs)-rs9639379, rs10272006, and rs6461569-has been determined in a population of 352 patients diagnosed clinically with AD, 290 patients with FTLD, and 341 age-matched controls. Expression analysis of SP4 was performed in peripheral blood mononuclear cells (PBMC). No significant differences in either allelic or genotypic frequency of the three SNPs were found (p > 0.05), even stratifying according to gender and to the apolipoprotein E status. Significantly increased SP4 relative expression levels were observed in PBMC from patients with AD as compared with controls (7.132 +/- 1.301 versus 3.396 +/- 0.829, p < 0.050) and a similar trend was shown in patients with FTLD compared with controls (6.525 +/- 1.500 versus 3.396 +/- 0.829, p = 0.073). According to these results, SP4 gene does not act as a susceptibility factor either for AD or FTLD. However, Sp4 mRNA levels are upregulated in patients, possibly resulting in an aberrant expression of downstream target genes involved in the pathogenesis of both diseases

Published
2012

59. Epidural premotor cortical stimulation in primary focal dystonia: clinical and 18F-fluoro deoxyglucose positron emission tomography open study

Author

Lalli, S, Piacentini, Sylvie, Franzini, Angelo Amato, Panzacchi, A, Cerami, C, Messina, G, Ferré, F, Perani, D, Albanese, Alberto, Albanese, Alberto (ORCID:0000-0002-5864-0006), Lalli, S, Piacentini, Sylvie, Franzini, Angelo Amato, Panzacchi, A, Cerami, C, Messina, G, Ferré, F, Perani, D, Albanese, Alberto, and Albanese, Alberto (ORCID:0000-0002-5864-0006)

Abstract

The aim of this study was to evaluate the efficacy and safety of epidural premotor stimulation in patients with primary focal dystonia. Seven patients were selected: 6 had cervical dystonia and 1 had right upper limb dystonia. In 2 patients, sustained muscle contractions led to a prevalently fixed head posture. Patients with cervical dystonia received a bilateral implant, whereas the patient with hand dystonia received a unilateral implant. Neurological and neuropsychological evaluations were performed before surgery (baseline), and 1, 3, 6, and 12 months afterward. The Burke-Fahn-Marsden scale (BFMS) and the Toronto Western spasmodic torticollis rating scale (TWSTRS) were administered at the same time points. Patients underwent resting (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) scans, before and 12 months after surgery. No adverse events occurred. An overall improvement was observed on the BFMS and TWSTRS after surgery. Patients with prevalently fixed cervical dystonia had a reduced benefit. Presurgical neuroimaging revealed a significant bilateral metabolic increase in the sensorimotor areas, which was reduced after surgery.

Published
2012

60. From genotype to phenotype: two cases of genetic frontotemporal lobar degeneration with premorbid bipolar disorder

Author

Cerami, C, Marcone, A, Galimberti, D, Villa, C, Scarpini, E, Cappa, S, Cappa, SF, VILLA, CHIARA, Cerami, C, Marcone, A, Galimberti, D, Villa, C, Scarpini, E, Cappa, S, Cappa, SF, and VILLA, CHIARA

Abstract

Frontotemporal lobar degeneration (FTLD) is a common early-onset dementia, which shows highly heterogeneous phenotypic presentations. Although an autosomal dominant transmission can be found only in about 10% cases, familial aggregation is frequently observed in FTLD. Recently, the progranulin gene (GRN) was reported to be involved in the disease pathogenesis. We describe two clinically different, apparently sporadic FTLD cases, sharing the previously described GRN mutation g.11019-11022delCACT (relative to nt1, NCBI NG-007886.1), alias Thr272fs, with a premorbid psychiatric history. Both patients are males and were in their sixties when diagnosed clinically with, respectively, the behavioral variant of frontotemporal dementia (bvFTD) and progressive nonfluent aphasia (PNFA). In both cases, the medical history revealed the presence of bipolar spectrum disorders. Mutations in GRN are considered to be a major cause of FTLD. However, the phenotypes associated with these mutations are highly variable. Our description of two novel FTLD genetic cases confirms the high frequency of the g.11019-11022delCACT mutation in Northern Italy. On this basis, we recommend to consider the presence of this mutation as a possible cause of the disease, particularly in patients with premorbid psychiatric symptoms. © 2011-IOS Press and the authors. All rights reserved.

Published
2011

69. Epidural premotor cortical stimulation in primary focal dystonia: clinical and 18F-fluoro deoxyglucose positron emission tomography open study.

Author

Lalli S, Piacentini S, Franzini A, Panzacchi A, Cerami C, Messina G, Ferré F, Perani D, Albanese A, Lalli, Stefania, Piacentini, Sylvie, Franzini, Angelo, Panzacchi, Andrea, Cerami, Chiara, Messina, Giuseppe, Ferré, Francesca, Perani, Daniela, and Albanese, Alberto

Abstract

The aim of this study was to evaluate the efficacy and safety of epidural premotor stimulation in patients with primary focal dystonia. Seven patients were selected: 6 had cervical dystonia and 1 had right upper limb dystonia. In 2 patients, sustained muscle contractions led to a prevalently fixed head posture. Patients with cervical dystonia received a bilateral implant, whereas the patient with hand dystonia received a unilateral implant. Neurological and neuropsychological evaluations were performed before surgery (baseline), and 1, 3, 6, and 12 months afterward. The Burke-Fahn-Marsden scale (BFMS) and the Toronto Western spasmodic torticollis rating scale (TWSTRS) were administered at the same time points. Patients underwent resting (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) scans, before and 12 months after surgery. No adverse events occurred. An overall improvement was observed on the BFMS and TWSTRS after surgery. Patients with prevalently fixed cervical dystonia had a reduced benefit. Presurgical neuroimaging revealed a significant bilateral metabolic increase in the sensorimotor areas, which was reduced after surgery. [ABSTRACT FROM AUTHOR]

Published
2012
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72. Advanced glycosylation endproducts on erythrocyte cell surface induce receptor-mediated phagocytosis by macrophages. A model for turnover of aging cells.

Author

Vlassara, H, Valinsky, J, Brownlee, M, Cerami, C, Nishimoto, S, and Cerami, A

Abstract

Glucose can react nonenzymatically with amino groups of proteins to form covalent Amadori products. With time these adducts undergo further rearrangements to form irreversible advanced glycosylation endproducts (AGE), which accumulate with protein age. A specific AGE, 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole (FFI), has been identified on proteins in vivo. We have recently shown that a macrophage receptor specifically recognizes and internalizes proteins modified by AGE such as FFI, thus preferentially degrading senescent macromolecules. Reasoning that cellular turnover may be mediated by macrophage recognition of AGE-membrane proteins, we prepared human RBCs with FFI attached chemically. Human monocytes were incubated with either FFI-RBCs, IgG-opsonized RBCs, or PBS-treated RBCs. Erythrophagocytosis of FFI-RBCs was significantly higher than that of PBS-RBCs (55 vs. 4%; p less than 0.0025) and almost as high as that of IgG-RBCs (70%), and was competitively inhibited by AGE-BSA. AGE-RBCs were also prepared by incubating RBCs with various sugars. Human monocytes showed a 15% ingestion of glucose-RBCs, and a 26% ingestion of glucose-6-phosphate-RBCs, compared to 6% for PBS-RBCs. Similarly, diabetic mouse RBCs were phagocytosed by nearly three times more cells (21%) than normal mouse RBCs when exposed to syngeneic mouse macrophages. This phagocytosis was competitively inhibited (70%) by addition of excess AGE-BSA. The in vivo half-life of 51Cr-labeled mouse FFI-RBCs injected into syngeneic mice was reduced to 7 d, as compared to a half-life of 20 d for the controls. These data suggest that the macrophage receptor for the removal of glucose-modified proteins may also mediate the endocytosis of RBCs with AGE formed on their surface, and thus be responsible in part for the removal of some populations of aging cells.

Published
1987
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74. Genetics and expression analysis of the transcription factor Sp4 in patients with Alzheimer's disease and frontotemporal lobar degeneration

Author

Galimberti, D., Villa, C., Fenoglio, C., Maria Serpente, Ghidoni, R., Benussi, L., Marcone, A., Cappa, S., Clerici, F., Franceschi, M., Rainero, I., Gallone, S., Ridolfi, E., Ghezzi, L., Bonsi, R., Cerami, C., Binetti, G., Mariani, C., Bresolin, N., and Scarpini, E.

Subjects
frontotemporal lobar degeneration, transcription factor Sp4, Alzheimer's disease

75. Iron and infection : neonatal iron transition

Author

Cross, J. H., Cerami, C., and Prentice, A. M.

Subjects
618.92
Abstract

Neonates, particularly those born preterm (PTB) and low birthweight (LBW), are especially susceptible to bacterial infections that cause an estimated 225,000 deaths annually. Iron is a vital substrate for the most common organisms causing septicaemia. Full-term babies elicit an immediate post-natal hypoferremia assumed to have evolved as an innate defence. This thesis aimed to test whether preterm and low birthweight newborns are capable of a similar response. A longitudinal observational study was conducted in 430 hospital-delivered Gambian babies. Demographic, anthropometric and haematological data were collected from 152 babies who were either PTB (between ≥32- < 37 weeks gestational age) and/or LBW (< 2500g) (PTB/LBW) and 278 full-term, normal-weight babies (FTB/NBW). Blood was sampled from the umbilical cord and matched venous blood samples from all neonates between 6-24 hours after delivery. An additional matched venous blood sample was taken from all full-term, normal birth weight newborns between 24-192 hours of life. In both FTB/NBW and PTB/LBW neonates, serum iron decreased 3-fold compared to umbilical blood concentrations within 12h of delivery (23·3±0·35 vs 7·5±0·22 ng/ml, P < 0.001, n=425). Hepcidin levels doubled (27·0±0·96 vs 52·9±1·63 ng/ml, P < 0·001, n=425). In FTB/NBW neonates, a steady increase in serum iron and TSAT follows (to 16.5±3.9μmol/L and 36.7±9.2% respectively by 136-192hrs postdelivery), even in the presence of relatively high serum hepcidin levels (45.2±19.1ng/ml) suggestive of hepcidin resistance possibly caused by iron saturation of macrophages. Our findings confirm that a very rapid hypoferremia occurs in the early hours of post-natal life with evidence that it is mediated by an increase in hepcidin. The strength and consistency of this effect in all neonates indicates that it may have evolved as an innate immune response designed to protect newborns from bacterial septicaemia.

Published
2020
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76. Biomarker-based stability in limbic-predominant amnestic mild cognitive impairment

Author

Roberto Santangelo, Giuseppe Magnani, C Cerami, Daniela Perani, Massimo Filippi, Alzheimer’s Disease Neuroimaging Initiative, Sandro Iannaccone, Luca Presotto, Giacomo Tondo, Giulia Carli, Maria Vittoria Mattoli, Tondo, G., Carli, G., Santangelo, R., Mattoli, M. V., Presotto, L., Filippi, M., Magnani, G., Iannaccone, S., Cerami, C., Perani, D., Tondo, G, Carli, G, Santangelo, R, Mattoli, M, Presotto, L, Filippi, M, Magnani, G, Iannaccone, S, Cerami, C, and Perani, D

Subjects
Oncology, medicine.medical_specialty, behavioral disciplines and activities, cerebrospinal fluid, 03 medical and health sciences, 0302 clinical medicine, mild cognitive impairment, Alzheimer Disease, Fluorodeoxyglucose F18, Internal medicine, mental disorders, medicine, Dementia, Humans, Cognitive Dysfunction, 030212 general & internal medicine, limbic-predominant, Retrospective Studies, Fluorodeoxyglucose, business.industry, tauopathy, Area under the curve, Brain, F]FDG-PET, Retrospective cohort study, medicine.disease, Clinical trial, Neurology, Positron-Emission Tomography, Cohort, Biomarker (medicine), Neurology (clinical), Tauopathy, business, [, 030217 neurology & neurosurgery, Biomarkers, medicine.drug
Abstract

Background: The amnestic presentation of mild cognitive impairment (aMCI) represents the most common prodromal stage of Alzheimer's disease (AD) dementia. There is, however, some evidence of aMCI with typical amnestic syndrome but showing long-term clinical stability. The ability to predict stability or progression to dementia in the aMCI condition is important, particularly for the selection of candidates in clinical trials. We aimed to establish the role of in vivo biomarkers, as assessed by cerebrospinal fluid (CSF) measures and [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging, in predicting prognosis in a large aMCI cohort. Methods: We conducted a retrospective study, including 142 aMCI subjects who had a long follow-up (4–19years), baseline CSF data and [18F]FDG-PET scans individually assessed by validated voxel-based procedures, classifying subjects into either limbic-predominant or AD-like hypometabolism patterns. Results: The two aMCI cohorts were clinically comparable at baseline. At follow-up, the aMCI group with a limbic-predominant [18F]FDG-PET pattern showed clinical stability over a very long follow-up (8.20±3.30years), no decline in Mini-Mental State Examination score, and only 7% conversion to dementia. Conversely, the aMCI group with an AD-like [18F]FDG-PET pattern had a high rate of dementia progression (86%) over a shorter follow-up (6.47±2.07years). Individual [18F]FDG-PET hypometabolism patterns predicted stability or conversion with high accuracy (area under the curve=0.89), sensitivity (0.90) and specificity (0.89). In the limbic-predominant aMCI cohort, CSF biomarkers showed large variability and no prognostic value. Conclusions: In a large series of clinically comparable subjects with aMCI at baseline, the specific [18F]FDG-PET limbic-predominant hypometabolism pattern was associated with clinical stability, making progression to AD very unlikely. The identification of a biomarker-based benign course in aMCI subjects has important implications for prognosis and in planning clinical trials.

Published
2021

79. Social and moral psychology of COVID-19 across 69 countries

Author

Flavio Azevedo, Tomislav Pavlović, Gabriel G. Rêgo, F. Ceren Ay, Biljana Gjoneska, Tom W. Etienne, Robert M. Ross, Philipp Schönegger, Julián C. Riaño-Moreno, Aleksandra Cichocka, Valerio Capraro, Luca Cian, Chiara Longoni, Ho Fai Chan, Jay J. Van Bavel, Hallgeir Sjåstad, John B. Nezlek, Mark Alfano, Michele J. Gelfand, Michèle D. Birtel, Aleksandra Cislak, Patricia L. Lockwood, Koen Abts, Elena Agadullina, John Jamir Benzon Aruta, Sahba Nomvula Besharati, Alexander Bor, Becky L. Choma, Charles David Crabtree, William A. Cunningham, Koustav De, Waqas Ejaz, Christian T. Elbaek, Andrej Findor, Daniel Flichtentrei, Renata Franc, June Gruber, Estrella Gualda, Yusaku Horiuchi, Toan Luu Duc Huynh, Agustin Ibanez, Mostak Ahamed Imran, Jacob Israelashvili, Katarzyna Jasko, Jaroslaw Kantorowicz, Elena Kantorowicz-Reznichenko, André Krouwel, Michael Laakasuo, Claus Lamm, Caroline Leygue, Ming-Jen Lin, Mohammad Sabbir Mansoor, Antoine Marie, Lewend Mayiwar, Honorata Mazepus, Cillian McHugh, John Paul Minda, Panagiotis Mitkidis, Andreas Olsson, Tobias Otterbring, Dominic J. Packer, Anat Perry, Michael Bang Petersen, Arathy Puthillam, Tobias Rothmund, Hernando Santamaría-García, Petra C. Schmid, Drozdstoy Stoyanov, Shruti Tewari, Bojan Todosijević, Manos Tsakiris, Hans H. Tung, Radu G. Umbres, Edmunds Vanags, Madalina Vlasceanu, Andrew Vonasch, Meltem Yucel, Yucheng Zhang, Mohcine Abad, Eli Adler, Narin Akrawi, Hamza Alaoui Mdarhri, Hanane Amara, David M. Amodio, Benedict G. Antazo, Matthew Apps, Mouhamadou Hady Ba, Sergio Barbosa, Brock Bastian, Anton Berg, Maria P. Bernal-Zárate, Michael Bernstein, Michał Białek, Ennio Bilancini, Natalia Bogatyreva, Leonardo Boncinelli, Jonathan E. Booth, Sylvie Borau, Ondrej Buchel, C. Daryl Cameron, Chrissie F. Carvalho, Tatiana Celadin, Chiara Cerami, Hom Nath Chalise, Xiaojun Cheng, Kate Cockcroft, Jane Conway, Mateo Andres Córdoba-Delgado, Chiara Crespi, Marie Crouzevialle, Jo Cutler, Marzena Cypryańska, Justyna Dabrowska, Michael A. Daniels, Victoria H. Davis, Pamala N. Dayley, Sylvain Delouvée, Ognjan Denkovski, Guillaume Dezecache, Nathan A. Dhaliwal, Alelie B. Diato, Roberto Di Paolo, Marianna Drosinou, Uwe Dulleck, Jānis Ekmanis, Arhan S. Ertan, Hapsa Hossain Farhana, Fahima Farkhari, Harry Farmer, Ali Fenwick, Kristijan Fidanovski, Terry Flew, Shona Fraser, Raymond Boadi Frempong, Jonathan A. Fugelsang, Jessica Gale, E. Begoña Garcia-Navarro, Prasad Garladinne, Oussama Ghajjou, Theofilos Gkinopoulos, Kurt Gray, Siobhán M. Griffin, Bjarki Gronfeldt, Mert Gümren, Ranju Lama Gurung, Eran Halperin, Elizabeth Harris, Volo Herzon, Matej Hruška, Guanxiong Huang, Matthias F. C. Hudecek, Ozan Isler, Simon Jangard, Frederik J. Jorgensen, Frank Kachanoff, John Kahn, Apsara Katuwal Dangol, Oleksandra Keudel, Lina Koppel, Mika Koverola, Emily Kubin, Anton Kunnari, Yordan Kutiyski, Oscar Moreda Laguna, Josh Leota, Eva Lermer, Jonathan Levy, Neil Levy, Chunyun Li, Elizabeth U. Long, Marina Maglić, Darragh McCashin, Alexander L. Metcalf, Igor Mikloušić, Soulaimane El Mimouni, Asako Miura, Juliana Molina-Paredes, César Monroy-Fonseca, Elena Morales-Marente, David Moreau, Rafał Muda, Annalisa Myer, Kyle Nash, Tarik Nesh-Nash, Jonas P. Nitschke, Matthew S. Nurse, Yohsuke Ohtsubo, Victoria Oldemburgo de Mello, Cathal O’Madagain, Michal Onderco, M. Soledad Palacios-Galvez, Jussi Palomöki, Yafeng Pan, Zsófia Papp, Philip Pärnamets, Mariola Paruzel-Czachura, Zoran Pavlović, César Payán-Gómez, Silva Perander, Michael Mark Pitman, Rajib Prasad, Joanna Pyrkosz-Pacyna, Steve Rathje, Ali Raza, Kasey Rhee, Claire E. Robertson, Iván Rodríguez-Pascual, Teemu Saikkonen, Octavio Salvador-Ginez, Gaia C. Santi, Natalia Santiago-Tovar, David Savage, Julian A. Scheffer, David T. Schultner, Enid M. Schutte, Andy Scott, Madhavi Sharma, Pujan Sharma, Ahmed Skali, David Stadelmann, Clara Alexandra Stafford, Dragan Stanojević, Anna Stefaniak, Anni Sternisko, Augustin Stoica, Kristina K. Stoyanova, Brent Strickland, Jukka Sundvall, Jeffrey P. Thomas, Gustav Tinghög, Benno Torgler, Iris J. Traast, Raffaele Tucciarelli, Michael Tyrala, Nick D. Ungson, Mete S. Uysal, Paul A. M. Van Lange, Jan-Willem van Prooijen, Dirk van Rooy, Daniel Västfjäll, Peter Verkoeijen, Joana B. Vieira, Christian von Sikorski, Alexander Cameron Walker, Jennifer Watermeyer, Erik Wetter, Ashley Whillans, Katherine White, Rishad Habib, Robin Willardt, Michael J. A. Wohl, Adrian Dominik Wójcik, Kaidi Wu, Yuki Yamada, Onurcan Yilmaz, Kumar Yogeeswaran, Carolin-Theresa Ziemer, Rolf A. Zwaan, Paulo S. Boggio, Waldir M. 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University of Cambridge Repository, Law and Economics, Pharmacy, Policy, Politics and Society, Molecular Genetics, Methods & Skills, Brain & Cognition, Azevedo, F, Pavlovic, T, Rego, G, Ay, F, Gjoneska, B, Etienne, T, Ross, R, Schonegger, P, Riano-Moreno, J, Cichocka, A, Capraro, V, Cian, L, Longoni, C, Chan, H, Van Bavel, J, Sjastad, H, Nezlek, J, Alfano, M, Gelfand, M, Birtel, M, Cislak, A, Lockwood, P, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomoki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, White, K, Habib, R, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, Boggio, P, Sampaio, W, Communication Science, Network Institute, Communication Choices, Content and Consequences (CCCC), Social & Organizational Psychology, Social Psychology, Amsterdam Sustainability Institute, IBBA, and A-LAB

Subjects
Statistics and Probability, SELF-ESTEEM, public support, physical hygiene, Library and Information Sciences, Settore SECS-P/02 - Politica Economica, Morals, Education, SDG 3 - Good Health and Well-being, Surveys and Questionnaires, open science, Humans, Social Change, Settore SECS-P/01 - Economia Politica, OLDER-ADULTS, Pandemics, Science & Technology, public health, social distancing, COVID-19, social psychology, Computer Science Applications, Multidisciplinary Sciences, Attitude, Socioeconomic Factors, moral psychology, international dataset, Science & Technology - Other Topics, COVID-19/psychology, HEALTH, Statistics, Probability and Uncertainty, SINGLE-ITEM MEASURE, Information Systems
Abstract

The COVID-19 pandemic has affected all domains of human life, including the economic and social fabric of societies. One of the central strategies for managing public health throughout the pandemic has been through persuasive messaging and collective behaviour change. To help scholars better understand the social and moral psychology behind public health behaviour, we present a dataset comprising of 51,404 individuals from 69 countries. This dataset was collected for the International Collaboration on Social & Moral Psychology of COVID-19 project (ICSMP COVID-19). This social science survey invited participants around the world to complete a series of moral and psychological measures and public health attitudes about COVID-19 during an early phase of the COVID-19 pandemic (between April and June 2020). The survey included seven broad categories of questions: COVID-19 beliefs and compliance behaviours; identity and social attitudes; ideology; health and well-being; moral beliefs and motivation; personality traits; and demographic variables. We report both raw and cleaned data, along with all survey materials, data visualisations, and psychometric evaluations of key variables. ispartof: SCIENTIFIC DATA vol:10 issue:1 ispartof: location:England status: published

Published
2023
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80. Diffusion tensor imaging evidence of corticospinal pathway involvement in frontotemporal lobar degeneration

Author

Chiara Crespi, Stefano F. Cappa, C Cerami, Alessandra Marcone, Andrea Falini, Alessandra Dodich, Sandro Iannaccone, Crespi, C, Dodich, A, Iannaccone, S, Marcone, A, Falini, A, Cappa, Sf, and Cerami, C

Subjects
Pathology, medicine.medical_specialty, Cognitive Neuroscience, Pyramidal Tracts, Experimental and Cognitive Psychology, Corpus callosum, 050105 experimental psychology, Primary progressive aphasia, White matter, 03 medical and health sciences, 0302 clinical medicine, mental disorders, medicine, Humans, Corticobasal degeneration, 0501 psychology and cognitive sciences, Pyramidal tracts, 05 social sciences, nutritional and metabolic diseases, Frontotemporal lobar degeneration, medicine.disease, nervous system diseases, Diffusion Tensor Imaging, Neuropsychology and Physiological Psychology, medicine.anatomical_structure, Frontotemporal Dementia, Corticospinal tract, Frontotemporal Lobar Degeneration, Psychology, human activities, 030217 neurology & neurosurgery, Diffusion MRI
Abstract

Motor neuron dysfunctions (MNDys) in Frontotemporal Lobar Degeneration (FTLD) have been consistently reported. Clinical and neurophysiological findings proved a variable range of pathological changes, also affecting the corticospinal tract (CST). This study aims to assess white-matter microstructural alterations in a sample of patients with FTLD, and to evaluate the relationship with MNDys. Fifty-four FTLD patients (21 bvFTD, 16 PPA, 17 CBS) and 36 healthy controls participated in a Diffusion Tensor Imaging (DTI) study. We analyzed distinctive and common microstructural alteration patterns across FTLD subtypes, including those affecting the CST, and performed an association analysis between CST integrity and the presence of clinical and/or neurophysiological signs of MNDys. The majority of FTLD patients showed microstructural changes in the motor pathway with a high prevalence of CST alterations also in patients not displaying clinical and/or neurophysiological signs of MNDys. Our results suggest that subtle CST alterations characterize FTLD patients regardless to the subtype. This may be due to the spread of the pathological process to the motor system, even without a clear clinical manifestation of MNDys.

Published
2020
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81. National identity predicts public health support during a global pandemic

Author

Van Bavel, Jay J., Cichocka, Aleksandra, Capraro, Valerio, Sjåstad, Hallgeir, Nezlek, John B., Pavlović, Tomislav, Alfano, Mark, Gelfand, Michele J., Azevedo, Flavio, Birtel, Michèle D., Cislak, Aleksandra, Lockwood, Patricia L., Ross, Robert Malcolm, Abts, Koen, Agadullina, Elena, Aruta, John Jamir Benzon, Besharati, Sahba Nomvula, Bor, Alexander, Choma, Becky L., Crabtree, Charles David, Cunningham, William A., De, Koustav, Ejaz, Waqas, Elbaek, Christian T., Findor, Andrej, Flichtentrei, Daniel, Franc, Renata, Gjoneska, Biljana, Gruber, June, Gualda, Estrella, Horiuchi, Yusaku, Huynh, Toan Luu Duc, Ibanez, Agustin, Imran, Mostak Ahamed, Israelashvili, Jacob, Jasko, Katarzyna, Kantorowicz, Jaroslaw, Kantorowicz-Reznichenko, Elena, Krouwel, André, Laakasuo, Michael, Lamm, Claus, Leygue, Caroline, Lin, Ming-Jen, Mansoor, Mohammad Sabbir, Marie, Antoine, Mayiwar, Lewend, Mazepus, Honorata, McHugh, Cillian, Minda, John Paul, Mitkidis, Panagiotis, Olsson, Andreas, Otterbring, Tobias, Packer, Dominic J., Perry, Anat, Petersen, Michael Bang, Puthillam, Arathy, Riaño-Moreno, Julián C., Rothmund, Tobias, Santamaría-García, Hernando, Schmid, Petra C., Stoyanov, Drozdstoy, Tewari, Shruti, Todosijević, Bojan, Tsakiris, Manos, Tung, Hans H., Umbreș, Radu G., Vanags, Edmunds, Vlasceanu, Madalina, Vonasch, Andrew, Yucel, Meltem, Zhang, Yucheng, Abad, Mohcine, Adler, Eli, Akrawi, Narin, Mdarhri, Hamza Alaoui, Amara, Hanane, Amodio, David M., Antazo, Benedict G., Apps, Matthew, Ay, F. Ceren, Ba, Mouhamadou Hady, Barbosa, Sergio, Bastian, Brock, Berg, Anton, Bernal-Zárate, Maria P., Bernstein, Michael, Białek, Michał, Bilancini, Ennio, Bogatyreva, Natalia, Boncinelli, Leonardo, Booth, Jonathan E., Borau, Sylvie, Buchel, Ondrej, Cameron, C. Daryl, Carvalho, Chrissie F., Celadin, Tatiana, Cerami, Chiara, Chalise, Hom Nath, Cheng, Xiaojun, Cian, Luca, Cockcroft, Kate, Conway, Jane, Córdoba-Delgado, Mateo Andres, Crespi, Chiara, Crouzevialle, Marie, Cutler, Jo, Cypryańska, Marzena, Dabrowska, Justyna, Daniels, Michael A., Davis, Victoria H., Dayley, Pamala N., Delouvee, Sylvain, Denkovski, Ognjan, Dezecache, Guillaume, Dhaliwal, Nathan A., Diato, Alelie B., Di Paolo, Roberto, Drosinou, Marianna, Dulleck, Uwe, Ekmanis, Jānis, Ertan, Arhan S., Etienne, Tom W., Farhana, Hapsa Hossain, Farkhari, Fahima, Farmer, Harry, Fenwick, Ali, Fidanovski, Kristijan, Flew, Terry, Fraser, Shona, Frempong, Raymond Boadi, Fugelsang, Jonathan A., Gale, Jessica, Garcia-Navarro, E. Begoña, Garladinne, Prasad, Ghajjou, Oussama, Gkinopoulos, Theofilos, Gray, Kurt, Griffin, Siobhán M., Gronfeldt, Bjarki, Gümren, Mert, Gurung, Ranju Lama, Halperin, Eran, Harris, Elizabeth, Herzon, Volo, Hruška, Matej, Huang, Guanxiong, Hudecek, Matthias F. C., Isler, Ozan, Jangard, Simon, Jørgensen, Frederik J., Kachanoff, Frank, Kahn, John, Dangol, Apsara Katuwal, Keudel, Oleksandra, Koppel, Lina, Koverola, Mika, Kubin, Emily, Kunnari, Anton, Kutiyski, Yordan, Laguna, Oscar, Leota, Josh, Lermer, Eva, Levy, Jonathan, Levy, Neil, Li, Chunyun, Long, Elizabeth U., Longoni, Chiara, Maglić, Marina, McCashin, Darragh, Metcalf, Alexander L., Mikloušić, Igor, El Mimouni, Soulaimane, Miura, Asako, Molina-Paredes, Juliana, Monroy-Fonseca, César, Morales-Marente, Elena, Moreau, David, Muda, Rafał, Myer, Annalisa, Nash, Kyle, Nesh-Nash, Tarik, Nitschke, Jonas P., Nurse, Matthew S., Ohtsubo, Yohsuke, Oldemburgo De Mello, Victoria, O’Madagain, Cathal, Onderco, Michal, Palacios-Galvez, M. Soledad, Palomäki, Jussi, Pan, Yafeng, Papp, Zsófia, Pärnamets, Philip, Paruzel-Czachura, Mariola, Pavlović, Zoran, Payán-Gómez, César, Perander, Silva, Pitman, Michael Mark, Prasad, Rajib, Pyrkosz-Pacyna, Joanna, Rathje, Steve, Raza, Ali, Rêgo, Gabriel G., Rhee, Kasey, Robertson, Claire E., Rodríguez-Pascual, Iván, Saikkonen, Teemu, Salvador-Ginez, Octavio, Sampaio, Waldir M., Santi, Gaia C., Santiago-Tovar, Natalia, Savage, David, Scheffer, Julian A., Schönegger, Philipp, Schultner, David T., Schutte, Enid M., Scott, Andy, Sharma, Madhavi, Sharma, Pujan, Skali, Ahmed, Stadelmann, David, Stafford, Clara Alexandra, Stanojević, Dragan, Stefaniak, Anna, Sternisko, Anni, Stoica, Agustin, Stoyanova, Kristina K., Strickland, Brent, Sundvall, Jukka, Thomas, Jeffrey P., Tinghög, Gustav, Torgler, Benno, Traast, Iris J., Tucciarelli, Raffaele, Tyrala, Michael, Ungson, Nick D., Uysal, Mete S., Van Lange, Paul A. M., Van Prooijen, Jan-Willem, Van Rooy, Dirk, Västfjäll, Daniel, Verkoeijen, Peter, Vieira, Joana B., Von Sikorski, Christian, Walker, Alexander Cameron, Watermeyer, Jennifer, Wetter, Erik, Whillans, Ashley, Willardt, Robin, Wohl, Michael J. A., Wójcik, Adrian Dominik, Wu, Kaidi, Yamada, Yuki, Yilmaz, Onurcan, Yogeeswaran, Kumar, Ziemer, Carolin-Theresa, Zwaan, Rolf A., Boggio, Paulo S., Van Bavel, Jay J., Cichocka, Aleksandra, Capraro, Valerio, Sjåstad, Hallgeir, Nezlek, John B., Pavlović, Tomislav, Alfano, Mark, Gelfand, Michele J., Azevedo, Flavio, Birtel, Michèle D., Cislak, Aleksandra, Lockwood, Patricia L., Ross, Robert Malcolm, Abts, Koen, Agadullina, Elena, Aruta, John Jamir Benzon, Besharati, Sahba Nomvula, Bor, Alexander, Choma, Becky L., Crabtree, Charles David, Cunningham, William A., De, Koustav, Ejaz, Waqa, Elbaek, Christian T., Findor, Andrej, Flichtentrei, Daniel, Franc, Renata, Gjoneska, Biljana, Gruber, June, Gualda, Estrella, Horiuchi, Yusaku, Huynh, Toan Luu Duc, Ibanez, Augustin, Imran, Mostak Ahamed, Israelashvili, Jacob, Jasko, Katarzyna, Kantorowicz, Jaroslaw, Kantorowicz-Reznichenko, Elena, Krouwel, André, Laakasuo, Michael, Lamm, Clau, Leygue, Caroline, Lin, Ming-Jen, Mansoor, Mohammad Sabbir, Marie, Antoine, Mayiwar, Lewend, Mazepus, Honorata, McHugh, Cillian, Minda, John Paul, Mitkidis, Panagioti, Olsson, Andrea, Otterbring, Tobia, Packer, Dominic J., Perry, Anat, Petersen, Michael Bang, Puthillam, Arathy, Riaño-Moreno, Julián C., Rothmund, Tobia, Santamaría-García, Hernando, Schmid, Petra C., Stoyanov, Drozdstoy, Tewari, Shruti, Todosijević, Bojan, Tsakiris, Mano, Tung, Hans H., Umbreș, Radu G., Vanags, Edmund, Vlasceanu, Madalina, Vonasch, Andrew, Yucel, Meltem, Zhang, Yucheng, Abad, Mohcine, Adler, Eli, Akrawi, Narin, Mdarhri, Hamza Alaoui, Amara, Hanane, Amodio, David M., Antazo, Benedict G., Apps, Matthew, Ay, F. Ceren, Ba, Mouhamadou Hady, Barbosa, Sergio, Bastian, Brock, Berg, Anton, Bernal-Zárate, Maria P., Bernstein, Michael, Białek, Michał, Bilancini, Ennio, Bogatyreva, Natalia, Boncinelli, Leonardo, Booth, Jonathan E., Borau, Sylvie, Buchel, Ondrej, Cameron, C. Daryl, Carvalho, Chrissie F., Celadin, Tatiana, Cerami, Chiara, Chalise, Hom Nath, Cheng, Xiaojun, Cian, Luca, Cockcroft, Kate, Conway, Jane, Córdoba-Delgado, Mateo Andre, Crespi, Chiara, Crouzevialle, Marie, Cutler, Jo, Cypryańska, Marzena, Dabrowska, Justyna, Daniels, Michael A., Davis, Victoria H., Dayley, Pamala N., Delouvee, Sylvain, Denkovski, Ognjan, Dezecache, Guillaume, Dhaliwal, Nathan A., Diato, Alelie B., Di Paolo, Roberto, Drosinou, Marianna, Dulleck, Uwe, Ekmanis, Jāni, Ertan, Arhan S., Etienne, Tom W., Farhana, Hapsa Hossain, Farkhari, Fahima, Farmer, Harry, Fenwick, Ali, Fidanovski, Kristijan, Flew, Terry, Fraser, Shona, Frempong, Raymond Boadi, Fugelsang, Jonathan A., Gale, Jessica, Garcia-Navarro, E. Begoña, Garladinne, Prasad, Ghajjou, Oussama, Gkinopoulos, Theofilo, Gray, Kurt, Griffin, Siobhán M., Gronfeldt, Bjarki, Gümren, Mert, Gurung, Ranju Lama, Halperin, Eran, Harris, Elizabeth, Herzon, Volo, Hruška, Matej, Huang, Guanxiong, Hudecek, Matthias F. C., Isler, Ozan, Jangard, Simon, Jørgensen, Frederik J., Kachanoff, Frank, Kahn, John, Dangol, Apsara Katuwal, Keudel, Oleksandra, Koppel, Lina, Koverola, Mika, Kubin, Emily, Kunnari, Anton, Kutiyski, Yordan, Laguna, Oscar, Leota, Josh, Lermer, Eva, Levy, Jonathan, Levy, Neil, Li, Chunyun, Long, Elizabeth U., Longoni, Chiara, Maglić, Marina, McCashin, Darragh, Metcalf, Alexander L., Mikloušić, Igor, El Mimouni, Soulaimane, Miura, Asako, Molina-Paredes, Juliana, Monroy-Fonseca, César, Morales-Marente, Elena, Moreau, David, Muda, Rafał, Myer, Annalisa, Nash, Kyle, Nesh-Nash, Tarik, Nitschke, Jonas P., Nurse, Matthew S., Ohtsubo, Yohsuke, Oldemburgo de Mello, Victoria, O’Madagain, Cathal, Onderco, Michal, Palacios-Galvez, M. Soledad, Palomäki, Jussi, Pan, Yafeng, Papp, Zsófia, Pärnamets, Philip, Paruzel-Czachura, Mariola, Pavlović, Zoran, Payán-Gómez, César, Perander, Silva, Pitman, Michael Mark, Prasad, Rajib, Pyrkosz-Pacyna, Joanna, Rathje, Steve, Raza, Ali, Rêgo, Gabriel G., Rhee, Kasey, Robertson, Claire E., Rodríguez-Pascual, Iván, Saikkonen, Teemu, Salvador-Ginez, Octavio, Sampaio, Waldir M., Santi, Gaia C., Santiago-Tovar, Natalia, Savage, David, Scheffer, Julian A., Schönegger, Philipp, Schultner, David T., Schutte, Enid M., Scott, Andy, Sharma, Madhavi, Sharma, Pujan, Skali, Ahmed, Stadelmann, David, Stafford, Clara Alexandra, Stanojević, Dragan, Stefaniak, Anna, Sternisko, Anni, Stoica, Augustin, Stoyanova, Kristina K., Strickland, Brent, Sundvall, Jukka, Thomas, Jeffrey P., Tinghög, Gustav, Torgler, Benno, Traast, Iris J., Tucciarelli, Raffaele, Tyrala, Michael, Ungson, Nick D., Uysal, Mete S., Van Lange, Paul A. M., van Prooijen, Jan-Willem, van Rooy, Dirk, Västfjäll, Daniel, Verkoeijen, Peter, Vieira, Joana B., von Sikorski, Christian, Walker, Alexander Cameron, Watermeyer, Jennifer, Wetter, Erik, Whillans, Ashley, Willardt, Robin, Wohl, Michael J. A., Wójcik, Adrian Dominik, Wu, Kaidi, Yamada, Yuki, Yilmaz, Onurcan, Yogeeswaran, Kumar, Ziemer, Carolin-Theresa, Zwaan, Rolf A., Boggio, Paulo S., Department of Digital Humanities, Faculty Common Matters (Faculty of Arts), Cognitive Science, Helsinki Research Hub on Religion, Media and Social Change, Helsinki Social Computing Group, Doctoral Programme in Cognition, Learning, Instruction and Communication, Mind and Matter, High Performance Cognition group, Medicum, Digital Humanities, Law and Economics, Pharmacy, Public Administration, Molecular Genetics, Research Methods and Techniques, Brain and Cognition, Van Bavel, Jay J [0000-0002-2520-0442], Cichocka, Aleksandra [0000-0003-1703-1586], Sjåstad, Hallgeir [0000-0002-8730-1038], Nezlek, John B [0000-0003-4963-3637], Pavlović, Tomislav [0000-0002-4470-3715], Alfano, Mark [0000-0001-5879-8033], Azevedo, Flavio [0000-0001-9000-8513], Cislak, Aleksandra [0000-0002-9880-6947], Lockwood, Patricia L [0000-0001-7195-9559], Ross, Robert Malcolm [0000-0001-8711-1675], Abts, Koen [0000-0001-8546-8347], Agadullina, Elena [0000-0002-1505-1412], Aruta, John Jamir Benzon [0000-0003-4155-1063], Besharati, Sahba Nomvula [0000-0003-2836-7982], Bor, Alexander [0000-0002-2624-9221], Crabtree, Charles David [0000-0001-5144-8671], De, Koustav [0000-0001-9562-0672], Ejaz, Waqas [0000-0002-2492-4115], Elbaek, Christian T [0000-0002-7039-4565], Findor, Andrej [0000-0002-5896-6989], Franc, Renata [0000-0002-1909-2393], Gjoneska, Biljana [0000-0003-1200-6672], Huynh, Toan Luu Duc [0000-0002-1486-127X], Ibanez, Augustin [0000-0001-6758-5101], Imran, Mostak Ahamed [0000-0002-5101-3149], Kantorowicz, Jaroslaw [0000-0002-1186-5427], Krouwel, André [0000-0003-0952-6028], Laakasuo, Michael [0000-0003-2826-6073], Lamm, Claus [0000-0002-5422-0653], Leygue, Caroline [0000-0002-0355-1030], Lin, Ming-Jen [0000-0002-7174-2226], Mansoor, Mohammad Sabbir [0000-0002-6541-3506], Marie, Antoine [0000-0002-7958-0153], McHugh, Cillian [0000-0002-9701-3232], Minda, John Paul [0000-0002-4081-010X], Mitkidis, Panagiotis [0000-0002-9495-7369], Olsson, Andreas [0000-0001-5272-7744], Otterbring, Tobias [0000-0002-0283-8777], Perry, Anat [0000-0003-2329-856X], Petersen, Michael Bang [0000-0002-6782-5635], Riaño-Moreno, Julián C [0000-0003-4182-0550], Rothmund, Tobias [0000-0003-2979-5129], Schmid, Petra C [0000-0002-9990-5445], Stoyanov, Drozdstoy [0000-0002-9975-3680], Todosijević, Bojan [0000-0002-6116-993X], Tsakiris, Manos [0000-0001-7753-7576], Tung, Hans H [0000-0001-5332-7582], Vanags, Edmunds [0000-0003-1932-936X], Vlasceanu, Madalina [0000-0003-2138-1968], Yucel, Meltem [0000-0002-7274-5971], Zhang, Yucheng [0000-0001-9435-6734], Abad, Mohcine [0000-0002-4964-5411], Mdarhri, Hamza Alaoui [0000-0001-9831-6561], Amara, Hanane [0000-0003-0732-2320], Antazo, Benedict G [0000-0001-9993-8960], Apps, Matthew [0000-0001-5793-2202], Barbosa, Sergio [0000-0003-1989-158X], Bastian, Brock [0000-0003-4619-3322], Bernal-Zárate, Maria P [0000-0001-8232-6220], Białek, Michał [0000-0002-5062-5733], Boncinelli, Leonardo [0000-0003-0626-5133], Booth, Jonathan E [0000-0002-8563-4613], Borau, Sylvie [0000-0003-1564-0695], Buchel, Ondrej [0000-0002-0139-5513], Chalise, Hom Nath [0000-0002-9301-6890], Cian, Luca [0000-0002-8051-1366], Cockcroft, Kate [0000-0002-6166-8050], Conway, Jane [0000-0003-3883-349X], Córdoba-Delgado, Mateo Andres [0000-0002-2264-7388], Crouzevialle, Marie [0000-0002-5538-6030], Cutler, Jo [0000-0003-1073-764X], Dabrowska, Justyna [0000-0002-8821-7161], Davis, Victoria H [0000-0002-7207-4629], Dayley, Pamala N [0000-0001-8955-9502], Delouvee, Sylvain [0000-0002-4029-597X], Di Paolo, Roberto [0000-0002-6081-6656], Dulleck, Uwe [0000-0002-0953-5963], Ekmanis, Jānis [0000-0003-1781-1785], Etienne, Tom W [0000-0002-4299-6593], Farkhari, Fahima [0000-0002-8484-5128], Farmer, Harry [0000-0002-3684-0605], Fenwick, Ali [0000-0002-5412-9745], Flew, Terry [0000-0003-4485-9338], Frempong, Raymond Boadi [0000-0002-4603-5570], Gale, Jessica [0000-0001-5677-8629], Garcia-Navarro, E Begoña [0000-0001-6913-8882], Ghajjou, Oussama [0000-0002-2975-0265], Griffin, Siobhán M [0000-0002-3613-2844], Halperin, Eran [0000-0002-3379-2935], Herzon, Volo [0000-0001-7781-1651], Huang, Guanxiong [0000-0002-8588-1454], Hudecek, Matthias FC [0000-0002-7696-766X], Isler, Ozan [0000-0002-4638-2230], Jangard, Simon [0000-0002-7876-4161], Jørgensen, Frederik J [0000-0002-5461-912X], Kahn, John [0000-0002-0548-3123], Koppel, Lina [0000-0002-6302-0047], Koverola, Mika [0000-0001-8227-6120], Leota, Josh [0000-0002-7714-4630], Lermer, Eva [0000-0002-6600-9580], Maglić, Marina [0000-0002-6851-4601], Metcalf, Alexander L [0000-0001-9532-585X], Miura, Asako [0000-0002-7563-7503], Monroy-Fonseca, César [0000-0003-4696-8159], Morales-Marente, Elena [0000-0002-1227-9606], Moreau, David [0000-0002-1957-1941], Nesh-Nash, Tarik [0000-0002-5532-9095], Nitschke, Jonas P [0000-0002-3244-8585], Nurse, Matthew S [0000-0003-1787-5914], Palomäki, Jussi [0000-0001-6063-0926], Pan, Yafeng [0000-0002-5633-8313], Pavlović, Zoran [0000-0002-9231-5100], Payán-Gómez, César [0000-0002-0633-1332], Perander, Silva [0000-0001-6711-8079], Pitman, Michael Mark [0000-0001-5532-5388], Pyrkosz-Pacyna, Joanna [0000-0002-9112-8629], Raza, Ali [0000-0002-2438-6054], Rhee, Kasey [0000-0002-8562-0801], Rodríguez-Pascual, Iván [0000-0002-5385-3643], Saikkonen, Teemu [0000-0001-9619-3270], Sampaio, Waldir M [0000-0002-6066-4314], Schönegger, Philipp [0000-0001-9930-487X], Schultner, David T [0000-0003-2253-4065], Scott, Andy [0000-0002-3294-0078], Skali, Ahmed [0000-0002-4753-3280], Stadelmann, David [0000-0002-1211-9936], Stafford, Clara Alexandra [0000-0003-1716-7870], Stanojević, Dragan [0000-0002-3667-2461], Stefaniak, Anna [0000-0002-1706-7784], Sternisko, Anni [0000-0002-2507-3076], Stoica, Augustin [0000-0003-0585-1114], Sundvall, Jukka [0000-0003-4310-1162], Tinghög, Gustav [0000-0002-8159-1249], Torgler, Benno [0000-0002-9809-963X], Tucciarelli, Raffaele [0000-0002-0342-308X], Tyrala, Michael [0000-0001-5268-8319], Van Lange, Paul AM [0000-0001-7774-6984], van Prooijen, Jan-Willem [0000-0001-6236-0819], Västfjäll, Daniel [0000-0003-2873-4500], von Sikorski, Christian [0000-0002-3787-8277], Walker, Alexander Cameron [0000-0003-1431-6770], Watermeyer, Jennifer [0000-0001-7918-8832], Whillans, Ashley [0000-0002-1726-6978], Willardt, Robin [0000-0002-2495-3450], Wohl, Michael JA [0000-0001-6945-5562], Wójcik, Adrian Dominik [0000-0002-7073-6019], Wu, Kaidi [0000-0001-6881-7437], Yamada, Yuki [0000-0003-1431-568X], Yilmaz, Onurcan [0000-0002-6094-7162], Ziemer, Carolin-Theresa [0000-0002-0794-7702], Apollo - University of Cambridge Repository, Communication Science, Network Institute, Communication Choices, Content and Consequences (CCCC), Social Psychology, IBBA, A-LAB, New York University [New York] (NYU), NYU System (NYU), University of Kent [Canterbury], Middlesex University [London], Norwegian School of Economics and Business Administration, SWPS University of Social Sciences and Humanities (SWPS), College of William and Mary [Williamsburg] (WM), Ivo Pilar Institute of Social Sciences, Macquarie University, Stanford University, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], University of Greenwich, University of Oxford, University of Birmingham [Birmingham], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] (HSE), De La Salle University [Manila] (DLSU), University of the Witwatersrand [Johannesburg] (WITS), Aarhus University [Aarhus], University of Toronto, Dartmouth College [Hanover], University of Kentucky (UK), National University of Sciences and Technology [Islamabad] (NUST), Comenius University in Bratislava, IntraMed, Buenos Aires, DF, Argentina, Macedonian Academy of Sciences and Arts [Skopje, North Macedonia] (MASA), University of Colorado [Boulder], Universidad de Huelva, WHU-Otto Beisheim School of Management, University Adolfo Ibanez (Santiago), University of Dhaka, The Hebrew University of Jerusalem (HUJ), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Universiteit Leiden, Erasmus University Rotterdam, Vrije Universiteit Amsterdam [Amsterdam] (VU), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Vienna [Vienna], Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), National Taiwan University [Taiwan] (NTU), Tribhuvan University, BI Norwegian Business School [Oslo], University of Limerick (UL), University of Western Ontario (UWO), Duke University [Durham], Karolinska Institute, University of Agder (UIA), Lehigh University [Bethlehem], Monk Prayogshala, Cooperative University of Colombia, Pontificia Universidad Javeriana (PUJ), Department of Management, Technology, and Economics [ETH Zürich] (D-MTEC), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Medical University of Plovdiv, Indian Institute of Management Indore (IMM Indore), Institute of Social Sciences Belgrade, University of London [London], University of Luxembourg [Luxembourg], National School of Political and Administrative Studies (SNSPA), University of Latvia (LU), Princeton University, University of Canterbury [Christchurch], University of Virginia, Hebei University of Technology [Tianjin], Université Mohammed VI Polytechnique [Ben Guerir] (UM6P), Institute for Research and Development-Kurdistan, University of Amsterdam [Amsterdam] (UvA), Jose Rizal Memorial State University, Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Universidad del Rosario [Bogota], University of Melbourne, Penn State Abington, Pennsylvania Commonwealth System of Higher Education (PCSHE)-Penn State System, University of Wrocław [Poland] (UWr), IMT Alti Studi Lucca, Università degli Studi di Firenze = University of Florence (UniFI), London School of Economics and Political Science (LSE), Toulouse School of Economics (TSE-R), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Tilburg University [Tilburg], Netspar, Pennsylvania State University (Penn State), Penn State System, Universidade Federal de Santa Catarina = Federal University of Santa Catarina [Florianópolis] (UFSC), University of Bologna/Università di Bologna, Istituto Universitario di Studi Superiori (IUSS), Shenzhen University [Shenzhen], Institute for Advanced Study in Toulouse (IAST), Università degli Studi di Pavia = University of Pavia (UNIPV), Cracow University of Economics, University of British Columbia (UBC), University of California [Los Angeles] (UCLA), University of California (UC), Laboratoire de Psychologie : Cognition, Comportement, Communication (LP3C - EA1285), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Université de Brest (UBO), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), University of British Columbia [Vancouver], Cavite State University-General Trias City Campus, School for Advanced Studies Lucca (IMT), Queensland University of Technology [Brisbane] (QUT), Australian National University (ANU), Boǧaziçi üniversitesi = Boğaziçi University [Istanbul], Kieskompas, Hult International Business School Dubai, The University of Sydney, University of Bayreuth, University of Waterloo [Waterloo], University of Bradford, University of Crete [Heraklion] (UOC), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Koç University, City University of Hong Kong [Hong Kong] (CUHK), University of Regensburg, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Free University of Berlin (FU), Linköping University (LIU), University of Koblenz-Landau, University of Alberta, Ludwig Maximilian University [Munich] (LMU), Interdisciplinary Center Herzliya (IDC), Aalto University, Macquarie University [Sydney], Boston University [Boston] (BU), Dublin City University [Dublin] (DCU), University of Montana, Osaka University [Osaka], SEELE Neuroscience, University of Auckland [Auckland], Maria Curie-Sklodowska University (UMCS), CUNY Graduate Center (The Graduate Center), City University of New York [New York] (CUNY), The University of Tokyo (UTokyo), Mohammed VI Polytechnic University, Hungarian Academy of Sciences (MTA), Medical University of Silesia (SUM), University of Belgrade [Belgrade], Vidyasagar College For Women, AGH University of Science and Technology [Krakow, PL] (AGH UST), University of Cambridge [UK] (CAM), Mackenzie Presbyterian University [São Paulo] (UPM), University of Turku, University of Newcastle [Callaghan, Australia] (UoN), University of St Andrews [Scotland], University of Groningen [Groningen], Carleton University, National University of Political Studies and Public Administration Bucharest, Romania (SNSPA), University of Plovdiv, Institut Jean-Nicod (IJN), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Département de Philosophie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Center for Research in Economics, Management and the Arts (CREMA), Partenaires INRAE, University College of London [London] (UCL), The Hong Kong University of Science and Technology, Susquehanna University, Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] (DEÜ), Stockholm School of Economics (SSE), Harvard Business School, Harvard University, Nicolaus Copernicus University [Toruń], University of California [San Diego] (UC San Diego), Kyushu University, Kadir Has University (KHAS), Van Bavel, Jay J. [0000-0002-2520-0442], Nezlek, John B. [0000-0003-4963-3637], Lockwood, Patricia L. [0000-0001-7195-9559], Elbaek, Christian T. [0000-0002-7039-4565], Ibanez, Agustin [0000-0001-6758-5101], Riaño-Moreno, Julián C. [0000-0003-4182-0550], Schmid, Petra C. [0000-0002-9990-5445], Tung, Hans H. [0000-0001-5332-7582], Antazo, Benedict G. [0000-0001-9993-8960], Bernal-Zárate, Maria P. [0000-0001-8232-6220], Booth, Jonathan E. [0000-0002-8563-4613], Davis, Victoria H. [0000-0002-7207-4629], Dayley, Pamala N. [0000-0001-8955-9502], Etienne, Tom W. [0000-0002-4299-6593], Garcia-Navarro, E. Begoña [0000-0001-6913-8882], Griffin, Siobhán M. [0000-0002-3613-2844], Hudecek, Matthias F. C. [0000-0002-7696-766X], Jørgensen, Frederik J. [0000-0002-5461-912X], Metcalf, Alexander L. [0000-0001-9532-585X], Nitschke, Jonas P. [0000-0002-3244-8585], Nurse, Matthew S. [0000-0003-1787-5914], Sampaio, Waldir M. [0000-0002-6066-4314], Schultner, David T. [0000-0003-2253-4065], Stoica, Agustin [0000-0003-0585-1114], Van Lange, Paul A. M. [0000-0001-7774-6984], Wohl, Michael J. A. [0000-0001-6945-5562], New York University, University of Kent, Middlesex University, Norwegian School of Economics, College of William and Mary, Institute of Social Sciences Ivo Pilar, Friedrich Schiller University Jena, SWPS University of Social Sciences and Humanities, KU Leuven, Higher School of Economics, De La Salle University Manila, University of the Witwatersrand, Aarhus University, X University, Dartmouth College, University of Kentucky, National University of Sciences and Technology Pakistan, IntraMed, Macedonian Academy of Sciences and Arts, University of Colorado Boulder, University of Huelva, Otto Beisheim School of Management, Universidad Adolfo Ibáñez, Hebrew University of Jerusalem, Jagiellonian University in Kraków, Leiden University, Vrije Universiteit Amsterdam, University of Helsinki, University of Vienna, Universidad Nacional Autónoma de México, National Taiwan University, BI Norwegian Business School, University of Limerick, Western University, Karolinska Institutet, University of Agder, Lehigh University, Universidad Cooperativa de Colombia, Universidad Javeriana, Swiss Federal Institute of Technology Zurich, Indian Institute of Management Indore, Institute of Social Sciences, Royal Holloway University of London, University of Latvia, University of Canterbury, Duke University, Hebei University of Technology, University of Kurdistan, Impact For Development, Jose Rizal University, University of Birmingham, Université Cheikh Anta Diop de Dakar, Universidad del Rosario, Pennsylvania State University, University of Wrocław, IMT Institute for Advanced Studies Lucca, University of Florence, Birkbeck University of London, Toulouse Business School, Tilburg University, Universidade Federal de Santa Catarina, Universita di Bologna, University of Pavia, Shenzhen University, Université Toulouse 1 Capitole, IRCCS Fondazione Istituto Neurologico Casimiro Mondino - Pavia, University of British Columbia, University of California Los Angeles, University of Rennes 2, University of Amsterdam, Université Clermont Auvergne, Cavite State University, Queensland University of Technology, Bogazici University, University of Sydney, University of Waterloo, University of North Carolina at Chapel Hill, Koc University, City University of Hong Kong, Free University of Berlin, Linköping University, Ludwig Maximilian University of Munich, Department of Neuroscience and Biomedical Engineering, Boston University, Dublin City University, Osaka University, University of Auckland, Maria Curie-Sklodowska University, Australian National University, The University of Tokyo, Hungarian Academy of Sciences, University of Silesia in Katowice, University of Belgrade, University of Calcutta, AGH University of Science and Technology, University of Cambridge, Universidade Presbiteriana Mackenzie, University of Newcastle, University of St Andrews, University of Groningen, National School of Political and Administrative Studies, University College London, Hong Kong University of Science and Technology, Dokuz Eylul University, Stockholm School of Economics, Nicolaus Copernicus University in Toruń, University of California San Diego, Kadir Has University, Aalto-yliopisto, University of St Andrews. School of International Relations, University of St Andrews. School of Psychology and Neuroscience, Van Bavel, J, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, J, Pavlovic, T, Alfano, M, Gelfand, M, Azevedo, F, Birtel, M, Cislak, A, Lockwood, P, Ross, R, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Riano-Moreno, J, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ay, F, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Etienne, T, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Longoni, C, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, Oldemburgo de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, G, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, W, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schonegger, P, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, and Boggio, P

Subjects
IMAGE, Health Behavior, COVID-19, national identity, public health, pandemic, cross-cultural, Collective narcissism, Settore SECS-P/02 - Politica Economica, health behavior, Sociology, RA0421 Public health. Hygiene. Preventive Medicine, Settore SECS-P/01 - Economia Politica, public health behaviours, COVID-19, collective behaviour, Public health, [SHS.SOCIO]Humanities and Social Sciences/Sociology, Social Identification, 706/689/477/2811, article, Social identity, Public Health, Global Health, Social Medicine and Epidemiology, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, 3142 Public health care science, environmental and occupational health, VDP::Medisinske Fag: 700::Helsefag: 800, 5141 Sociology, Settore SECS-P/03 - Scienza delle Finanze, National identity, Human, Cross-Cultural Comparison, BF Psychology, Science, COVID-19 pandemic, BF, national narcissism, HV Social pathology. Social and public welfare. Criminology, Humans, Leadership, Pandemics, Public Health, SARS-CoV-2, Self Report, Social Conformity, Human development, 692/699/255/2514, SDG 3 - Good Health and Well-being, Human behaviour, political ideology, COLLECTIVE NARCISSISM, SOCIAL IDENTITY, MCC, Pandemic, IDENTIFICATION, DAS, [SHS.SCIPO]Humanities and Social Sciences/Political science, Coronavirus, MODEL, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Viral infection, Idenfication, Image, RA Public aspects of medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Human medicine, RA, Model
Abstract

Funder: Research Council of Norway through its Centres of Excellence Scheme, FAIR project No 262675, Funder: J. William Fulbright Program, Funder: Institute for Lifecourse Development, University of Greenwich, Funder: Economic Social Research Council Impact Acceleration Award, University of Oxford, Funder: Institute of Social Sciences Ivo Pilar, Funder: Academy of Finland (Suomen Akatemia); doi: https://doi.org/10.13039/501100002341, Funder: Universität Wien (University of Vienna); doi: https://doi.org/10.13039/501100003065, Funder: Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan); doi: https://doi.org/10.13039/501100004663, Funder: NOMIS Stiftung (NOMIS Foundation); doi: https://doi.org/10.13039/501100008483, Funder: Princeton Graduate Student Research Funding (Program in Cognitive Science), Funder: Corruption Laboratory on Ethics, Accountability, and the Rule of Law (CLEAR), University of Virginia, Funder: Project Pro.Co.P.E., IMT School (PAI2019), Funder: Italian Ministry of University and Research - PRIN 2017 (20178293XT), Funder: Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada); doi: https://doi.org/10.13039/501100000038, Funder: Australian Research Council (DP180102384), Funder: Ernst and Young (EY); doi: https://doi.org/10.13039/501100003064, Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = −0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.

Published
2022
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82. Large-Scale Functional Networks, Cognition and Brain Structures Supporting Social Cognition and Theory of Mind Performance in Prodromal to Mild Alzheimer’s Disease

Author

Jose Manuel Valera-Bermejo, Matteo De Marco, Micaela Mitolo, Chiara Cerami, Alessandra Dodich, Annalena Venneri, Valera-Bermejo J.M., De Marco M., Mitolo M., Cerami C., Dodich A., and Venneri A.

Subjects
Aging, Cognitive Neuroscience, Temporoparietal junction, fMRI, Neuropsychology, Cognition, Neurosciences. Biological psychiatry. Neuropsychiatry, social cognition, medicine.anatomical_structure, mild cognitive impairment, Social cognition, Theory of mind, medicine, Psychology, Prefrontal cortex, VBM, Insula, Alzheimer’s disease, Default mode network, Cognitive psychology, Neuroscience, Original Research, theory of mind, RC321-571
Abstract

Copyright © 2021 Valera-Bermejo, De Marco, Mitolo, Cerami, Dodich and Venneri. Impairment of social cognition (SC) skills such as recognition and attribution of intentions and affective states of others (Theory of Mind, ToM) has been evidenced in Alzheimer’s Disease (AD). This study investigated the neuropsychological, neuroanatomical and brain-functional underpinnings of SC processing to obtain an understanding of the social neurophenotype in early probable AD. Forty-six patients with mild cognitive impairment and mild probable AD underwent SC assessment including emotion recognition (Ekman-60-faces task) and cognitive and affective ToM (Reading-the-Mind-in-the-Eyes test and Story-based Empathy task). Linear models tested the association between SC scores and neuropsychological measures, grey matter maps and large-scale functional networks activity. The executive domain had the most predominant association with SC scores in the cognitive profile. Grey matter volume of the anterior cingulate, orbitofrontal, temporoparietal junction (TPJ), superior temporal, and cerebellar cortices were associated with ToM. Social cognition scores were associated with lower connectivity of the default-mode network with the prefrontal cortex. The right fronto-parietal network displayed higher inter-network connectivity in the right TPJ and insula while the salience network showed lower inter-network connectivity with the left TPJ and insula. Connectivity coupling alterations of executive-attentional networks may support default mode social-cognitive-associated decline through the recruitment of frontal executive mechanisms. European Union Seventh Framework Programme (FP7/2007 – 2013) under grant agreement no. 601055, VPH-DARE@IT; Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico.

Published
2021
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83. Qualitative Scoring of the Pentagon Test: A Tool for the Identification of Subtle Cognitive Deficits in Isolated REM Sleep Behavior Disorder Patients

Author

Pagnini Caterina, Luigi Ferini-Strambi, Andrea Galbiati, Alessandra Dodich, Sara Marelli, Giulia Carli, Marco Zucconi, Chiara Cerami, Galbiati, A., Carli, G., Dodich, A., Marelli, S., Caterina, P., Cerami, C., Zucconi, M., and Ferini-Strambi, L.

Subjects
Male, medicine.medical_specialty, Parasomnias, Polysomnography, Prodromal Symptoms, REM Sleep Behavior Disorder, Audiology, ddc:616.0757, Neuropsychological assessment, REM sleep behavior disorder, Executive Function, Cognitive aging, 03 medical and health sciences, 0302 clinical medicine, Assessment of cognitive disorders/dementia, Executive function, Humans, Medicine, Cognitive decline, Aged, Retrospective Studies, 030304 developmental biology, Slow-wave sleep, 0303 health sciences, Mini–Mental State Examination, medicine.diagnostic_test, business.industry, Electroencephalography, General Medicine, Parasomnia, Mental Status and Dementia Tests, medicine.disease, Executive functions, Psychiatry and Mental health, Clinical Psychology, Neuropsychology and Physiological Psychology, Case-Control Studies, Female, Cognition Disorders, business, 030217 neurology & neurosurgery
Abstract

Objective Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) frequently represents the prodromal stage of alpha-synucleinopathies, and similar to these pathologies, iRBD patients show neuropsychological deficits, particularly in the domain of visuospatial abilities and executive functions. We hypothesized that the qualitative scoring of the Mini-Mental State Examination pentagon test (QSPT) may detect subtle visuospatial deficits in these subjects, and we evaluated its relationship with indexes of sleep quality, as measured by polysomnography. Methods A total of 80 polysomnography-confirmed iRBD patients and 40 healthy controls (HCs) were retrospectively recruited. Global and specific qualitative performances were evaluated according to QSPT procedure. Comparisons between iRBD and HC regarding all QSPT parameters, neuropsychological tests, and polysomnographic recordings were performed. Results Patients displayed significantly lower scores in both “closing-in” and total score parameters in comparison to HC. The QSPT total score exhibited significant positive correlations with verbal comprehension, fluency, visuospatial abilities, and executive functions. Notably, iRBD patients with impaired performance at QSPT showed decreased neuropsychological performances and higher percentages of slow wave sleep (SWS). In addition, SWS percentages negatively correlated with verbal comprehension, fluency, visuospatial abilities, executive functions, and QSPT total score. Conclusion QSPT may represent a brief and easy to administer tool for the detection of subtle visuospatial changes in iRBD patients. Furthermore, polysomnographic findings suggest a possible slowdown of electroencephalographic pattern during non-REM sleep in iRBD patients in line with the presence of cognitive decline.

Published
2019
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84. Variant-specific vulnerability in metabolic connectivity and resting-state networks in behavioural variant of frontotemporal dementia

Author

Giuseppe Magnani, Arianna Sala, Giulia Carli, Daniela Perani, Sandro Iannaccone, Chiara Cerami, Maura Malpetti, Alessandra Marcone, Malpetti, M., Carli, G., Sala, A., Cerami, C., Marcone, A., Iannaccone, S., Magnani, G., Perani, D., Malpetti, Maura [0000-0001-8923-9656], and Apollo - University of Cambridge Repository

Subjects
Male, Positron emission tomography, Fluorine-18-flourodeoxiglucose, Cognitive Neuroscience, Vulnerability, Brain metabolic connectivity, Experimental and Cognitive Psychology, Neuropsychological Tests, behavioral disciplines and activities, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Cognition, Salience (neuroscience), Memory, medicine, Connectome, Humans, 0501 psychology and cognitive sciences, Behavioural variant of frontotemporal dementia, Attention, Aged, Brain Mapping, Resting state fMRI, Functional connectivity, 05 social sciences, Neuropsychology, Brain, Middle Aged, medicine.disease, Neuropsychology and Physiological Psychology, Frontotemporal Dementia, Positron-Emission Tomography, Correlation analysis, Female, Nerve Net, Psychology, Neuroscience, 030217 neurology & neurosurgery, Frontotemporal dementia
Abstract

Brain connectivity measures represent candidate biomarkers of neuronal dysfunction in neurodegenerative diseases. Previous findings suggest that the behavioural variant of frontotemporal dementia (bvFTD) and its variants (i.e., frontal and temporo-limbic) may be related to the vulnerability of distinct functional connectivity networks. In this study, 82 bvFTD patients were included, and two patient groups were identified as frontal and temporo-limbic bvFTD variants. Two advanced multivariate analytical approaches were applied to FDG-PET data, i.e., sparse inverse covariance estimation (SICE) method and seed-based interregional correlation analysis (IRCA). These advanced methods allowed the assessment of (i) the whole-brain metabolic connectivity, without any a priori assumption, and (ii) the main brain resting-state networks of crucial relevance for cognitive and behavioural functions. In the whole bvFTD group, we found dysfunctional connectivity patterns in frontal and limbic regions and in all major brain resting-state networks as compared to healthy controls (HC N = 82). In the two bvFTD variants, SICE and IRCA analyses identified variant-specific reconfigurations of whole-brain connectivity and resting-state networks. Specifically, the frontal bvFTD variant was characterised by metabolic connectivity alterations in orbitofrontal regions and anterior resting-state networks, while the temporo-limbic bvFTD variant was characterised by connectivity alterations in the limbic and salience networks. These results highlight different neural vulnerabilities in the two bvFTD variants, as shown by the dysfunctional connectivity patterns, with relevance for the different neuropsychological profiles. This new evidence provides further insight in the variability of bvFTD and may contribute to a more accurate classification of these patients.

Published
2020
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85. Iron and Infection: Neonatal Iron Transition

Author

Cross, JH, Cerami, C, and Prentice, AM

Abstract

Neonates, particularly those born preterm (PTB) and low birthweight (LBW), are especially susceptible to bacterial infections that cause an estimated 225,000 deaths annually. Iron is a vital substrate for the most common organisms causing septicaemia. Full-term babies elicit an immediate post-natal hypoferremia assumed to have evolved as an innate defence. This thesis aimed to test whether preterm and low birthweight newborns are capable of a similar response. A longitudinal observational study was conducted in 430 hospital-delivered Gambian babies. Demographic, anthropometric and haematological data were collected from 152 babies who were either PTB (between ≥32

Published
2020
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86. 11 C‐PK11195 PET–based molecular study of microglia activation in SOD1 amyotrophic lateral sclerosis

Author

Ilaria Bartolomei, Christian Lunetta, Leonardo Iaccarino, Fabrizio Salvi, Chiara Cerami, Daniela Perani, Lorena Mosca, Giovanna Vanoli, Angela Coliva, Giacomo Tondo, Luca Presotto, Valeria Masiello, Tondo, Giacomo, Iaccarino, Leonardo, Cerami, Chiara, Vanoli, Giovanna Emilia, Presotto, Luca, Masiello, Valeria, Coliva, Angela, Salvi, Fabrizio, Bartolomei, Ilaria, Mosca, Lorena, Lunetta, Christian, Perani, Daniela, Tondo, G, Iaccarino, L, Cerami, C, Vanoli, G, Presotto, L, Masiello, V, Coliva, A, Salvi, F, Bartolomei, I, Mosca, L, Lunetta, C, and Perani, D

Subjects
0301 basic medicine, Cerebellum, SOD1, Thalamus, prion disease, Neurosciences. Biological psychiatry. Neuropsychiatry, Gene mutation, 03 medical and health sciences, 0302 clinical medicine, medicine, Amyotrophic lateral sclerosis, RC346-429, Neuroinflammation, Research Articles, Microglia, business.industry, General Neuroscience, Neurodegeneration, full quantification, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, nervous system, kinetic modelling, Neurology. Diseases of the nervous system, Neurology (clinical), business, Neuroscience, 030217 neurology & neurosurgery, RC321-571, Research Article
Abstract

Objective Neuroinflammation is considered a key driver for neurodegeneration in several neurological diseases, including amyotrophic lateral sclerosis (ALS). SOD1 mutations cause about 20% of familial ALS, and related pathology might generate microglial activation triggering neurodegeneration. 11 C-PK11195 is the prototypical and most validated PET radiotracer, targeting the 18-kDa translocator protein which is overexpressed in activated microglia. In this study, we investigated microglia activation in asymptomatic (ASYM) and symptomatic (SYM) SOD1 mutated carriers, by using 11 C-PK11195 and PET imaging. Methods We included 20 subjects: 4 ASYM-carriers, neurologically normal, 6 SYM-carriers with probable ALS, and 10 healthy controls. A receptor parametric mapping procedure estimated 11 C-PK11195 binding potentials and voxel-wise statistical comparisons were performed at group and single-subject levels. Results Both the SYM- and ASYM-carriers showed significant microglia activation in cortical and subcortical structures, with variable patterns at individual level. Clusters of activation were present in occipital and temporal regions, cerebellum, thalamus, and medulla oblongata. Notably, SYM-carriers showed microglia activation also in supplementary and primary motor cortices and in the somatosensory regions. Interpretation In vivo neuroinflammation occurred in all SOD1 mutated cases since the presymptomatic stages, as shown by a significant cortical and subcortical microglia activation. The involvement of sensorimotor cortex became evident at the symptomatic disease stage. Although our data indicate the role of in vivo PET imaging for assessing resident microglia in the investigation of SOD1-ALS pathophysiology, further studies are needed to clarify the temporal and spatial dynamics of microglia activation and its relationship with neurodegeneration.

Published
2020

87. The Role of Single-Subject Brain Metabolic Patterns in the Early Differential Diagnosis of Primary Progressive Aphasias and in Prediction of Progression to Dementia

Author

Alessandra Marcone, Giuseppe Magnani, Daniela Perani, Elisabetta Pelagallo, Stefano F. Cappa, Roberto Santangelo, Alessandra Dodich, Sandro Iannaccone, Chiara Cerami, Lucia Greco, Cerami, C., Dodich, A., Greco, L., Iannaccone, S., Magnani, G., Marcone, A., Pelagallo, E., Santangelo, R., Cappa, STEFANO FRANCESCO, and Perani, DANIELA FELICITA L.

Subjects
Male, 0301 basic medicine, positron emission tomography, non fluent variant of primary progressive aphasia, Aphasiology, Neuropsychological Tests, Primary progressive aphasia, Cognition, 0302 clinical medicine, Corticobasal degeneration, logopenic variant of primary progressive aphasia, Precision Medicine, FDG-PET, Anarthria, biology, General Neuroscience, Brain, General Medicine, respiratory system, Psychiatry and Mental health, Clinical Psychology, Disease Progression, Female, Research Article, Frontotemporal dementia, semantic variant of primary progressive aphasia, Progressive supranuclear palsy, Diagnosis, Differential, 03 medical and health sciences, Fluorodeoxyglucose F18, medicine, Humans, Dementia, Aged, Retrospective Studies, business.industry, medicine.disease, biology.organism_classification, Aphasia, Primary Progressive, Early Diagnosis, 030104 developmental biology, Positron-Emission Tomography, primary progressive aphasia, Radiopharmaceuticals, Geriatrics and Gerontology, Differential diagnosis, business, Neuroscience, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

Background and Objective: Primary progressive aphasia (PPA) is a clinical syndrome due to different neurodegenerative conditions in which an accurate early diagnosis needs to be supported by a reliable diagnostic tool at the individual level. In this study, we investigated in PPA the FDG-PET brain metabolic patterns at the single-subject level, in order to assess the case-to-case variability and its relationship with clinical-neuropsychological findings. Material and Methods: 55 patients (i.e., 11 semantic variant/sv-PPA, 19 non fluent variant/nfv-PPA, 17 logopenic variant/lv-PPA, 3 slowly progressive anarthria/SPA, and 5 mixed PPA/m-PPA) were included. Clinical-neuropsychological information and FDG-PET data were acquired at baseline. A follow-up of 27.4±12.55 months evaluated the clinical progression. Brain metabolism was analyzed using an optimized and validated voxel-based SPM method at the single-subject level. Results: FDG-PET voxel-wise metabolic assessment revealed specific metabolic signatures characterizing each PPA variant at the individual level, reflecting the underlying neurodegeneration in language networks. Notably, additional dysfunctional patterns predicted clinical progression to specific dementia conditions. In the case of nfv-PPA, a metabolic pattern characterized by involvement of parietal, subcortical and brainstem structures predicted progression to a corticobasal degeneration syndrome or to progressive supranuclear palsy. lv-PPA and sv-PPA cases who progressed to Alzheimer’s disease and frontotemporal dementia at the follow-up presented with extended bilateral patterns at baseline. Discussion: Our results indicate that FDG-PET voxel-wise imaging is a valid biomarker for the early differential diagnosis of PPAs and for the prediction of progression to specific dementia condition. This study supports the use of FDG-PET imaging quantitative assessment in clinical settings for a better characterization of PPA individuals and prognostic definition of possible endo-phenotypes.

Published
2016
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88. Different FDG-PET metabolic patterns at single-subject level in the behavioral variant of fronto-temporal dementia

Author

Sandro Iannaccone, Stefano F. Cappa, Alessandra Marcone, Giuseppe Magnani, Chiara Cerami, Daniela Perani, Luigi Gianolli, Giada Lettieri, Alessandra Dodich, Cerami, C., Dodich, A., Lettieri, G., Iannaccone, S., Magnani, G., Marcone, A., Gianolli, L., Cappa, STEFANO FRANCESCO, and Perani, DANIELA FELICITA L.

Subjects
Male, 0301 basic medicine, FDG positron emission tomography, Memory, Long-Term, Behavioral variant of fronto-temporal dementia, Cognitive Neuroscience, Experimental and Cognitive Psychology, Neuropsychological Tests, Cognitive neuroscience, Statistical parametric mapping, Frontal variant of fronto-temporal dementia, Executive Function, 03 medical and health sciences, Cognition, 0302 clinical medicine, Neuroimaging, Fluorodeoxyglucose F18, medicine, Temporal variant of fronto-temporal dementia, Humans, Dementia, Language, Recall, Neuropsychology, Brain, medicine.disease, 030104 developmental biology, Neuropsychology and Physiological Psychology, Frontotemporal Dementia, Positron-Emission Tomography, Psychology, Neuroscience, 030217 neurology & neurosurgery, Frontotemporal dementia
Abstract

BACKGROUND: The diagnosis of probable behavioral variant of fronto-temporal dementia (bvFTD) according to current criteria requires the imaging evidence of frontal and/or anterior temporal atrophy or hypoperfusion/hypometabolism. Different variants of this pattern of brain involvement may, however, be found in individual cases, supporting the presence of heterogeneous phenotypes. OBJECTIVE: We examined in a case-by-case approach the FDG-PET metabolic patterns of patients fulfilling clinical criteria for probable bvFTD, assessing the presence and frequency of specific FDG-PET features. MATERIALS AND METHODS: Fifty two FDG-PET scans of probable bvFTD patients were retrospectively analyzed together with clinical and neuropsychological data. Neuroimaging experts rated the FDG-PET hypometabolism maps obtained at the single-subject level with optimized voxel-based Statistical Parametric Mapping (SPM). The functional metabolic heterogeneity was further tested by hierarchical cluster analysis and principal component analysis (PCA). RESULTS: Both the SPM maps and cluster analysis identified two major variants of cerebral hypometabolism, namely the "frontal" and the "temporo-limbic", which were correlated with different cognitive profiles. Executive and language deficits were the cognitive hallmark in the "frontal" subgroup, while poor encoding and recall on long-term memory tasks was typical of the "temporo-limbic" subgroup. DISCUSSION: SPM single-subject analysis indicates distinct patterns of brain dysfunction in bvFTD, coupled with specific clinical features, suggesting different profiles of neurodegenerative vulnerability. These findings have important implications for the early diagnosis of bvFTD and for the application of the recent international consensus criteria.

Published
2016
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89. Randomized controlled trial on the efficacy of a multilevel non-pharmacologic intervention in older adults with subjective memory decline: design and baseline findings of the E.Mu.N.I. study

Author

Elena Rolandi, Sara Mandelli, Alessandra Marcone, Enrica Cavedo, Alessandra Dodich, Roberto Gasparotti, Sandro Iannaccone, Samantha Galluzzi, Claudia Ambrosi, Chiara Cerami, Clarissa Ferrari, Federica Ribaldi, Davide Violi, Nicola Canessa, Harald Hampel, Giulio Munaretto, Andrea Falini, Giovanni B. Frisoni, Rolandi, Elena, Dodich, Alessandra, Galluzzi, Samantha, Ferrari, Clarissa, Mandelli, Sara, Ribaldi, Federica, Munaretto, Giulio, Ambrosi, Claudia, Gasparotti, Roberto, Violi, Davide, Canessa, Nicola, Iannaccone, Sandro, Marcone, Alessandra, Falini, Andrea, Hampel, Harald, Frisoni, Giovanni B., Cerami &amp, Chiara, Cavedo, Enrica, Rolandi, E, Dodich, A, Galluzzi, S, Ferrari, C, Mandelli, S, Ribaldi, F, Munaretto, G, Ambrosi, C, Gasparotti, R, Violi, D, Canessa, N, Iannaccone, S, Marcone, A, Falini, A, Hampel, H, Frisoni, Gb, Cerami, C, and Cavedo, E

Subjects
Male, Aging, medicine.medical_specialty, Psychological intervention, Physical exercise, Neuroimaging, Disease, ddc:616.0757, Primary prevention Alzheimer’s disease, law.invention, Non-pharmacologic intervention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Memory, medicine, Dementia, Humans, 030212 general & internal medicine, Exercise, Life Style, Aged Brain/physiopathology Dementia/physiopathology/*therapy Exercise Female Humans Life Style Magnetic Resonance Imaging Male *Memory Memory Disorders/physiopathology/*therapy Middle Aged Alzheimer’s disease Neuroimaging Non-pharmacologic interventions Primary prevention Subjective cognitive decline, Aged, Memory Disorders, Primary prevention, business.industry, Incidence (epidemiology), Brain, Cognition, Alzheimer's disease, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Cognitive training, Non-pharmacologic interventions, ddc:618.97, Physical therapy, Subjective cognitive decline, Female, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery
Abstract

Background: Alzheimer’s Disease (AD) is a multifactorial disorder driven by genetic and modifiable lifestyle risk factors. Lifestyle primary prevention initiatives may reduce the prevalence and incidence of dementia in older adults. Objectives: The E.Mu.N.I study is a randomized controlled trial investigating the effect of multilevel non-pharmacologic interventions on cognitive performances (primary outcome) and structural and vascular brain MRI markers (secondary outcome), as well as markers of brain functional connectivity change (exploratory outcome), in older adults with subjective memory decline (SMD). Here, we present the study design and the baseline features of the sample. Methods: Cognitively intact older adults with SMD, enrolled between February 2016 and June 2017, were randomly assigned to one of the 3 interventions for 1 year: Active Control Intervention (ACI), i.e., educational lessons; Partial Intervention (PI), i.e., homotaurine administration (100 mg/die) and lessons on the Mediterranean diet; Multilevel Intervention (MI), i.e., PI plus computerized cognitive training and physical exercise training. Results: One-hundred and twenty-eight eligible participants were enrolled (66% female; age: 68 ± 5 years). Eighty-two percent of the sample was composed of volunteers with SMD from the community. Participants were randomly allocated to the interventions as follows: ACI (N = 40), PI (N = 44), MI (N = 44). No significant differences among groups emerged on socio-demographic, clinical–neuropsychological variables and MRI markers at baseline. Conclusions: The outcomes obtained from the E.Mu.N.I. study will clarify the efficacy of multilevel non-pharmacologic interventions on cognitive and neuroimaging markers in SMD individuals. This is a crucial step forward for the development of cost-effective non-pharmacologic primary prevention initiatives for AD.

Published
2019

90. Social cognition dysfunctions in patients with epilepsy: Evidence from patients with temporal lobe and idiopathic generalized epilepsies

Author

Ornella Daniele, Alessandra Dodich, Brigida Fierro, Leila Zummo, Andrea Zizzo, Luigi Agrò, Chiara Cerami, Sabrina Realmuto, Nicola Canessa, Realmuto, S., Zummo, L., Cerami, C., Agrò, L., Dodich, A., Canessa, N., Zizzo, A., Fierro, B., and Daniele, O.

Subjects
Adult, Male, Idiopathic generalized epilepsy, medicine.medical_specialty, Emotions, Neuropsychological Tests, behavioral disciplines and activities, Behavioral Neuroscience, Epilepsy, Cognition, Social cognition, medicine, Neurobehavioral impairment, Humans, Neuropsychological assessment, Generalized epilepsy, Temporal lobe epilepsy, Social Behavior, Psychiatry, medicine.diagnostic_test, Neuropsychology, Middle Aged, medicine.disease, Temporal Lobe, Facial Expression, Epilepsy, Temporal Lobe, Social Perception, Neurology, Face, Epilepsy syndromes, Settore MED/26 - Neurologia, Epilepsy, Generalized, Female, Neurology (clinical), Empathy, Cognition Disorders, Psychology, psychological phenomena and processes, Clinical psychology
Abstract

Background and aim Despite an extensive literature on cognitive impairments in focal and generalized epilepsy, only a few number of studies specifically explored social cognition disorders in epilepsy syndromes. The aim of our study was to investigate social cognition abilities in patients with temporal lobe epilepsy (TLE) and in patients with idiopathic generalized epilepsy (IGE). Materials and methods Thirty-nine patients (21 patients with TLE and 18 patients with IGE) and 21 matched healthy controls (HCs) were recruited. All subjects underwent a basic neuropsychological battery plus two experimental tasks evaluating emotion recognition from facial expression (Ekman-60-Faces test, Ek-60F) and mental state attribution (Story-based Empathy Task, SET). In particular, the latter is a newly developed task that assesses the ability to infer others' intentions (i.e., intention attribution — IA) and emotions (i.e., emotion attribution — EA) compared with a control condition of physical causality (i.e., causal inferences — CI). Results Compared with HCs, patients with TLE showed significantly lower performances on both social cognition tasks. In particular, all SET subconditions as well as the recognition of negative emotions were significantly impaired in patients with TLE vs. HCs. On the contrary, patients with IGE showed impairments on anger recognition only without any deficit at the SET task. Discussion Emotion recognition deficits occur in patients with epilepsy, possibly because of a global disruption of a pathway involving frontal, temporal, and limbic regions. Impairments of mental state attribution specifically characterize the neuropsychological profile of patients with TLE in the context of the in-depth temporal dysfunction typical of such patients. Conclusion Impairments of socioemotional processing have to be considered as part of the neuropsychological assessment in both TLE and IGE in view of a correct management and for future therapeutic interventions.

Published
2015
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91. A biomarker study in long-lasting amnestic mild cognitive impairment

Author

Alessandra Marcone, Luigi Gianolli, Alessandra Dodich, Sandro Iannaccone, Chiara Cerami, Giuseppe Magnani, Daniela Perani, Roberto Santangelo, Luca Presotto, Stefano F. Cappa, Cerami, Chiara, Dodich, Alessandra, Iannaccone, Sandro, Magnani, Giuseppe, Santangelo, Roberto, Presotto, Luca, Marcone, Alessandra, Gianolli, Luigi, Cappa, Stefano F., Perani, Daniela, Cerami, C, Dodich, A, Iannaccone, S, Magnani, G, Santangelo, R, Presotto, L, Marcone, A, Gianolli, L, Cappa, S, and Perani, D

Subjects
0301 basic medicine, Male, Pathology, Neurology, Neuropsychological Tests, lcsh:RC346-429, 0302 clinical medicine, Limbic system, Image Processing, Computer-Assisted, Longitudinal Studies, FDG-PET, Aged, 80 and over, medicine.diagnostic_test, Neuropsychology, Alzheimer's disease, Magnetic Resonance Imaging, Amyloid-PET, medicine.anatomical_structure, Positron emission tomography, Biomarker (medicine), Female, Tauopathy, Alzheimer’s disease, medicine.medical_specialty, Cognitive Neuroscience, Medial temporal lobe dysfunction, tau Proteins, Temporal lobe, lcsh:RC321-571, 03 medical and health sciences, Fluorodeoxyglucose F18, mental disorders, medicine, Dementia, Humans, Cognitive Dysfunction, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:Neurology. Diseases of the nervous system, Aged, Amyloid beta-Peptides, business.industry, Research, Mild cognitive impairment, medicine.disease, Peptide Fragments, 030104 developmental biology, Positron-Emission Tomography, Neurology (clinical), business, Mental Status Schedule, 030217 neurology & neurosurgery
Abstract

Background: Mild cognitive impairment (MCI) is a heterogeneous syndrome resulting from Alzheimer's disease (AD) as well as to non-AD and non-neurodegenerative conditions. A subset of patients with amnestic MCI (aMCI) present with an unusually long-lasting course, a slow rate of clinical neuropsychological progression, and evidence of focal involvement of medial temporal lobe structures. In the present study, we explored positron emission tomography (PET) and cerebrospinal fluid (CSF) biomarkers in a sample of subjects with aMCI with such clinical features in order to provide in vivo evidence to improve disease characterisation in this subgroup.Methods: Thirty consecutive subjects with aMCI who had long-lasting memory impairment (more than 4 years from symptom onset) and a very slow rate of cognitive progression were included. All subjects underwent fluorodeoxyglucose-positron emission tomography (FDG-PET) metabolic imaging. A measure of cerebral amyloid load, by PET and/or CSF, was obtained in 26 of 30 subjects. The mean clinical follow-up was 58.3 ± 10.1 months.Results: No patient progressed to dementia during the follow-up. The typical AD FDG-PET pattern of temporoparietal hypometabolism was not present in any of the subjects. In contrast, a selective medial temporal lobe hypometabolism was present in all subjects, with an extension to frontolimbic regions in some subjects. PET imaging showed absent or low amyloid load in the majority of samples. The values were well below those reported in prodromal AD, and they were slightly elevated in only two subjects, consistent with the CSF β-amyloid (1–42) protein values. Notably, no amyloid load was present in the hippocampal structures.Conclusions: FDG-PET and amyloid-PET together with CSF findings questioned AD pathology as a unique neuropathological substrate in this aMCI subgroup with long-lasting disease course. The possibility of alternative pathological conditions, such as argyrophilic grain disease, primary age-related tauopathy or age-related TDP-43 proteinopathy, known to spread throughout the medial temporal lobe and limbic system structures should be considered in these patients with MCI.

Published
2018

92. FDG-PET and CSF biomarker accuracy in prediction of conversion to different dementias in a large multicentre MCI cohort

Author

Flavio Nobili, Federico Fallanca, Chiara Cerami, Giuseppe Magnani, Arianna Sala, Daniela Perani, Luigi Gianolli, Giovanni B. Frisoni, Lucilla Parnetti, Sandro Iannaccone, Emilia Giovanna Vanoli, Tommaso Ballarini, Paolo Eusebi, Silvia Paola Caminiti, Elio Scarpini, Roberto Santangelo, Luca Presotto, Agnese Picco, Caminiti, Silvia Paola, Ballarini, Tommaso, Sala, Arianna, Cerami, Chiara, Presotto, Luca, Santangelo, Roberto, Fallanca, Federico, Vanoli, Emilia Giovanna, Gianolli, Luigi, Iannaccone, Sandro, Magnani, Giuseppe, Perani, Daniela, Parnetti, Lucilla, Eusebi, Paolo, Frisoni, Giovanni, Nobili, Flavio, Picco, Agnese, Scarpini, Elio, Caminiti, S, Ballarini, T, Sala, A, Cerami, C, Presotto, L, Santangelo, R, Fallanca, F, Vanoli, E, Gianolli, L, Iannaccone, S, Magnani, G, Perani, D, Parnetti, L, Eusebi, P, Frisoni, G, Nobili, F, Picco, A, and Scarpini, E

Subjects
Oncology, Male, FTD, frontotemporal dementia, Radiology, Nuclear Medicine and Imaging, Neurology, FDG, fluorodeoxyglucose, Alzheimer's disease dementia, Neuropsychological Tests, CSF, cerebrospinal fluid, lcsh:RC346-429, 030218 nuclear medicine & medical imaging, LR-, negative likelihood ratio, 0302 clinical medicine, Nuclear Medicine and Imaging, Corticobasal degeneration, md naMCI, multi-domain non-amnestic mild cognitive impairment, Phosphorylation, naMCI, single-domain non-amnestic mild cognitive impairment, t-tau, total tau, Aged, 80 and over, Alzheimer's disease dementia, Clinical setting, Erlangen Score, Frontotemporal dementia, Prognosis, Radiology, Nuclear Medicine and Imaging, Neurology, Neurology (clinical), Cognitive Neuroscience, DLB, dementia with Lewy bodies, Neuropsychology, Brain, Regular Article, Middle Aged, Prognosis, md aMCI, multi-domain amnestic mild cognitive impairment, MCI, mild cognitive impairment, Disease Progression, Biomarker (medicine), PSP, progressive supranuclear palsy, lcsh:R858-859.7, Female, AD, Alzheimer's disease, Radiology, Frontotemporal dementia, CBD, corticobasal degeneration, medicine.medical_specialty, Clinical setting, Erlangen Score, Neurology (clinical), Cognitive Neuroscience, Prognosi, p-tau, phosphorylated tau, LR+, positive likelihood ratio, tau Proteins, aMCI, single-domain amnestic mild cognitive impairment, AUC, area under curve, lcsh:Computer applications to medicine. Medical informatics, Sensitivity and Specificity, PET, positron emission tomography, 03 medical and health sciences, Alzheimer Disease, Fluorodeoxyglucose F18, Internal medicine, mental disorders, medicine, Dementia, Humans, Radiology, Nuclear Medicine and imaging, Cognitive Dysfunction, lcsh:Neurology. Diseases of the nervous system, Aged, Amyloid beta-Peptides, business.industry, Dementia with Lewy bodies, Posterior cortical atrophy, medicine.disease, EANM, European Association of Nuclear Medicine, bvFTD, behavioral variant of frontotemporal dementia, CDR, Clinical Dementia Rating, Positron-Emission Tomography, business, 030217 neurology & neurosurgery, Biomarkers
Abstract

Background/aims In this multicentre study in clinical settings, we assessed the accuracy of optimized procedures for FDG-PET brain metabolism and CSF classifications in predicting or excluding the conversion to Alzheimer's disease (AD) dementia and non-AD dementias. Methods We included 80 MCI subjects with neurological and neuropsychological assessments, FDG-PET scan and CSF measures at entry, all with clinical follow-up. FDG-PET data were analysed with a validated voxel-based SPM method. Resulting single-subject SPM maps were classified by five imaging experts according to the disease-specific patterns, as “typical-AD”, “atypical-AD” (i.e. posterior cortical atrophy, asymmetric logopenic AD variant, frontal-AD variant), “non-AD” (i.e. behavioural variant FTD, corticobasal degeneration, semantic variant FTD; dementia with Lewy bodies) or “negative” patterns. To perform the statistical analyses, the individual patterns were grouped either as “AD dementia vs. non-AD dementia (all diseases)” or as “FTD vs. non-FTD (all diseases)”. Aβ42, total and phosphorylated Tau CSF-levels were classified dichotomously, and using the Erlangen Score algorithm. Multivariate logistic models tested the prognostic accuracy of FDG-PET-SPM and CSF dichotomous classifications. Accuracy of Erlangen score and Erlangen Score aided by FDG-PET SPM classification was evaluated. Results The multivariate logistic model identified FDG-PET “AD” SPM classification (Expβ = 19.35, 95% C.I. 4.8–77.8, p, Highlights • Appropriate biomarkers measures improve early dementia diagnosis in MCI. • FDG-PET-SPM maps and CSF Aβ42 are the best predictors of AD dementia conversion. • FDG-PET-SPM maps accurately predict conversion to different dementia conditions. • A negative FDG-PET-SPM pattern characterizes stable or reverter MCI cases.

Published
2018

93. Evaluation of an optimized [18F]fluoro-deoxy-glucose positron emission tomography voxel-wise method to early support differential diagnosis in atypical Parkinsonian disorders

Author

L. Majno, G. Comi, Silvia Paola Caminiti, Pierpaolo Alongi, Daniela Perani, Luigi Gianolli, Maria Antonietta Volontè, Chiara Cerami, Caminiti, S. P., Alongi, P., Majno, L., Volontã, M. A., Cerami, C., Gianolli, L., Comi, Giancarlo, and Perani, DANIELA FELICITA L.

Subjects
Male, Pathology, medicine.medical_specialty, multiple system atrophy, single subject, Statistical parametric mapping, hypometabolism, Basal Ganglia Disease, Sensitivity and Specificity, 030218 nuclear medicine & medical imaging, Progressive supranuclear palsy, Follow-Up Studie, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Atrophy, Retrospective Studie, Fluorodeoxyglucose F18, dementia with Lewy bodie, medicine, Corticobasal degeneration, Aged, Aged, 80 and over, medicine.diagnostic_test, Neurodegenerative Disease, Dementia with Lewy bodies, business.industry, Statistical Parametric Mapping, Parkinsonian Disorder, progressive supranuclear palsy, Middle Aged, medicine.disease, Neurology, Positron emission tomography, Positron-Emission Tomography, Biomarker (medicine), biomarker, Radiopharmaceutical, Female, Radiology, Neurology (clinical), Differential diagnosis, business, 030217 neurology & neurosurgery, corticobasal degeneration, Human
Abstract

Background and purpose: Atypical Parkinsonian disorders (APD) frequently overlap in clinical presentations, making the differential diagnosis challenging in the early stages. The present study aimed to evaluate the accuracy of the [18F]fluoro-deoxy-glucose positron emission tomography Statistical Parametric Mapping (SPM) optimized procedure in supporting the early and differential diagnosis of APD. Methods: Seventy patients with possible APD were retrospectively included from a large clinical cohort. The included patients underwent [18F]fluoro-deoxy-glucose positron emission tomography within 3 months of the first clinical assessment and a diagnostic follow-up. An optimized SPM voxel-wise procedure was used to produce t-maps of brain hypometabolism in single subjects, which were classified by experts blinded to any clinical information. We compared the accuracy of both the first clinical diagnosis and the SPM t-map classifications with the diagnosis at follow-up as the reference standard. Results: At first diagnosis, 60% of patients were classified as possible APD (progressive supranuclear palsy, corticobasal degeneration, dementia with Lewy bodies, multiple system atrophy) and about 40% as APD with uncertain diagnosis, providing 52% sensitivity, 97% specificity and 86% accuracy with respect to the reference standard. SPM t-map classification showed 98% sensitivity, 99% specificity and 99% accuracy, and a significant agreement with the diagnosis at follow-up (P < 0.001). Conclusions: The SPM t-map classification at entry predicted the second diagnosis at follow-up. This indicates its significantly superior role for an early identification of APD subtypes, particularly in cases of uncertain diagnosis. The use of a metabolic biomarker at entry in the instrumental work-up of APD may shorten the diagnostic time, producing benefits for treatment options and support to the patients.

Published
2017

94. Neuropsychological and FDG-PET profiles in VGKC autoimmune limbic encephalitis

Author

Pierpaolo Alongi, Alessandra Dodich, Sandro Iannaccone, Stefano F. Cappa, Chiara Cerami, Daniela Perani, Nicola Canessa, Alessandra Marcone, Chiara Crespi, Francesca Andreetta, Andrea Falini, Dodich, A, Cerami, C, Iannaccone, S, Marcone, A, Alongi, P, Crespi, C, Canessa, N, Andreetta, F, Falini, Andrea, Cappa, Sf, and Perani, DANIELA FELICITA L.

Subjects
Male, Cognitive Neuroscience, Memory, Episodic, Experimental and Cognitive Psychology, Neuropsychological Tests, Statistical parametric mapping, 030218 nuclear medicine & medical imaging, Temporal lobe, Autoimmune Diseases, 03 medical and health sciences, 0302 clinical medicine, Arts and Humanities (miscellaneous), Fluorodeoxyglucose F18, Limbic Encephalitis, Developmental and Educational Psychology, medicine, Humans, Neuropsychological assessment, Episodic memory, Aged, Autoantibodies, Memory Disorders, medicine.diagnostic_test, Limbic encephalitis, Neuropsychology, Cognition, Recognition, Psychology, Fear, Middle Aged, medicine.disease, Potassium channel complex, Neuropsychology and Physiological Psychology, Potassium Channels, Voltage-Gated, Positron-Emission Tomography, Female, Radiopharmaceuticals, Psychology, Neuroscience, 030217 neurology & neurosurgery
Abstract

Background Limbic encephalitis (LE) is characterized by an acute or subacute onset with memory impairments, confusional state, behavioral disorders, variably associated with seizures and dystonic movements. It is due to inflammatory processes that selectively affect the medial temporal lobe structures. Voltage-gate potassium channel (VGKC) autoantibodies are frequently observed. In this study, we assessed at the individual level FDG-PET brain metabolic dysfunctions and neuropsychological profiles in three autoimmune LE cases seropositive for neuronal VGKC-complex autoantibodies. Materials and methods LGI1 and CASPR2 potassium channel complex autoantibody subtyping was performed. Cognitive abilities were evaluated with an in-depth neuropsychological battery focused on episodic memory and affective recognition/processing skills. FDG-PET data were analyzed at single-subject level according to a standardized and validated voxel-based Statistical Parametric Mapping (SPM) method. Results Patients showed severe episodic memory and fear recognition deficits at the neuropsychological assessment. No disorder of mentalizing processing was present. Variable patterns of increases and decreases of brain glucose metabolism emerged in the limbic structures, highlighting the pathology-driven selective vulnerability of this system. Additional involvement of cortical and subcortical regions, particularly in the sensorimotor system and basal ganglia, was found. Conclusions Episodic memory and fear recognition deficits characterize the cognitive profile of LE. Commonalities and differences may occur in the brain metabolic patterns. Single-subject voxel-based analysis of FDG-PET imaging could be useful in the early detection of the metabolic correlates of cognitive and non-cognitive deficits characterizing LE condition.

Published
2016

95. A cervical myelopathy with a Hirayama disease-like phenotype

Author

Federico Piccoli, Francesca Valentino, Vincenzo La Bella, Chiara Cerami, CERAMI,C, VALENTINO,F, PICCOLI,F, and LA BELLA,V

Subjects
Male, medicine.medical_specialty, Weakness, HIRAYAMA, Neurology, Cumulative Trauma Disorders, Dermatology, Functional Laterality, Muscular Atrophy, Spinal, Young Adult, Myelopathy, Atrophy, Ischemia, Spinal cord compression, Neural Pathways, medicine, Humans, Kyphosis, Muscle, Skeletal, Cervical myelopathy, Hirayama disease, Muscular atrophy, MRI, Muscle Weakness, business.industry, Muscle weakness, Syndrome, General Medicine, Anatomy, Amyotrophy, medicine.disease, Magnetic Resonance Imaging, Cold Temperature, Occupational Diseases, Psychiatry and Mental health, medicine.anatomical_structure, Spinal Cord, Arm, Cervical Vertebrae, Disease Progression, Upper limb, Settore MED/26 - Neurologia, Neurology (clinical), medicine.symptom, business, Spinal Cord Compression
Abstract

A 21-year-old man with a muscular atrophy of the left distal upper extremity is presented. The disorder had been progressive over a few years, showing an exacerbation of the hand's weakness when the patient worked in a chilled environment (i.e., in a cold room). The patient's diagnostic work-up was extensive and the MRI documented the presence of a cervical myelopathy, associated to an inversion of the physiological lordosis at the C5-C6 level, with a phenotype highly resembling Hirayama disease. This case indirectly supports the debated hypothesis that juvenile amyotrophy of the upper limb (Hirayama disease) is actually a type of cervical myelopathy, with a likely ischaemic pathogenesis of the ventral horns. A 21-year-old man with a muscular atrophy of the left distal upper extremity is presented. The disorder had been progressive over a few years, showing an exacerbation of the hand's weakness when the patient worked in a chilled environment (i.e., in a cold room). The patient's diagnostic work-up was extensive and the MRI documented the presence of a cervical myelopathy, associated to an inversion of the physiological lordosis at the C5-C6 level, with a phenotype highly resembling Hirayama disease. This case indirectly supports the debated hypothesis that juvenile amyotrophy of the upper limb (Hirayama disease) is actually a type of cervical myelopathy, with a likely ischaemic pathogenesis of the ventral horns.

Published
2008
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96. Microstrucutral Correlates of Emotional Attribution Impairment in Non-Demented Patients with Amyotrophic Lateral Sclerosis

Author

Chiara Crespi, Stefano F. Cappa, Alessandra Dodich, Sandro Iannaccone, Chiara Cerami, Nicola Canessa, Christian Lunetta, Andrea Falini, Massimo Corbo, Crespi, C, Cerami, C, Dodich, A, Canessa, N, Iannaccone, S, Corbo, M, Lunetta, C, Falini, Andrea, and Cappa, Sf

Subjects
Social Cognition, Male, Emotions, lcsh:Medicine, Social Sciences, Neuropsychological Tests, Audiology, Corpus callosum, Diagnostic Radiology, Motor Neuron Diseases, Cognition, 0302 clinical medicine, Materials Physics, Medicine and Health Sciences, Psychology, Amyotrophic lateral sclerosis, Cognitive decline, lcsh:Science, Microstructure, media_common, Cognitive Impairment, Brain Mapping, Multidisciplinary, Cognitive Neurology, Physics, Radiology and Imaging, 05 social sciences, Brain, Neurodegenerative Diseases, Middle Aged, Magnetic Resonance Imaging, Facial Expression, Diffusion Tensor Imaging, Neurology, Physical Sciences, Female, Commissural fiber, Research Article, Frontotemporal dementia, medicine.medical_specialty, Social Psychology, Imaging Techniques, Cognitive Neuroscience, Brain Morphometry, media_common.quotation_subject, Materials Science, Neuroimaging, Empathy, Research and Analysis Methods, 050105 experimental psychology, 03 medical and health sciences, Diagnostic Medicine, Fractional anisotropy, medicine, Humans, 0501 psychology and cognitive sciences, Behavior, business.industry, lcsh:R, Amyotrophic Lateral Sclerosis, Cognitive Psychology, Biology and Life Sciences, medicine.disease, Case-Control Studies, Cognitive Science, lcsh:Q, Cognition Disorders, business, Attribution, 030217 neurology & neurosurgery, Neuroscience
Abstract

Impairments in the ability to recognize and attribute emotional states to others have been described in amyotrophic lateral sclerosis patients and linked to the dysfunction of key nodes of the emotional empathy network. Microstructural correlates of such disorders are still unexplored. We investigated the white-matter substrates of emotional attribution deficits in a sample of amyotrophic lateral sclerosis patients without cognitive decline. Thirteen individuals with either probable or definite amyotrophic lateral sclerosis and 14 healthy controls were enrolled in a Diffusion Tensor Imaging study and administered the Story-based Empathy Task, assessing the ability to attribute mental states to others (i.e., Intention and Emotion attribution conditions). As already reported, a significant global reduction of empathic skills, mainly driven by a failure in Emotion Attribution condition, was found in amyotrophic lateral sclerosis patients compared to healthy subjects. The severity of this deficit was significantly correlated with fractional anisotropy along the forceps minor, genu of corpus callosum, right uncinate and inferior fronto-occipital fasciculi. The involvement of frontal commissural fiber tracts and right ventral associative fronto-limbic pathways is the microstructural hallmark of the impairment of high-order processing of socio-emotional stimuli in amyotrophic lateral sclerosis. These results support the notion of the neurofunctional and neuroanatomical continuum between amyotrophic lateral sclerosis and frontotemporal dementia.

Published
2016

97. Cross-validation of biomarkers for the early differential diagnosis and prognosis of dementia in a clinical setting

Author

Sandro Iannaccone, Giancarlo Comi, Silvia Paola Caminiti, Giuseppe Magnani, P. Pinto, Stefano F. Cappa, Gabriella Passerini, Daniela Perani, L. Ferrari, E. Coppi, Luigi Gianolli, Roberto Santangelo, Chiara Cerami, Andrea Falini, Perani, DANIELA FELICITA L., Cerami, C, Caminiti, Sp, Santangelo, R, Coppi, E, Ferrari, L, Pinto, P, Passerini, G, Falini, Andrea, Iannaccone, S, Cappa, Sf, Comi, Giancarlo, Gianolli, L, and Magnani, G.

Subjects
Oncology, Lewy Body Disease, Male, medicine.medical_specialty, Pathology, Mild Cognitive Impairment, tau Proteins, Disease, 030218 nuclear medicine & medical imaging, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Dementia diagnosis, Alzheimer Disease, Fluorodeoxyglucose F18, Predictive Value of Tests, Internal medicine, mental disorders, medicine, Dementia, Humans, Radiology, Nuclear Medicine and imaging, Cognitive Dysfunction, Alzheimer’s Disease, Cognitive impairment, CSF albumin, Aged, Amyloid beta-Peptides, business.industry, Disease progression, Reproducibility of Results, General Medicine, Middle Aged, medicine.disease, Predictive value, Molecular biomarkers, Magnetic Resonance Imaging, Peptide Fragments, Clinical setting, Positron-Emission Tomography, Disease Progression, Female, Differential diagnosis, Frontotemporal Lobar Degeneration, business, 030217 neurology & neurosurgery, Biomarkers
Abstract

PURPOSE: The aim of this study was to evaluate the supportive role of molecular and structural biomarkers (CSF protein levels, FDG PET and MRI) in the early differential diagnosis of dementia in a large sample of patients with neurodegenerative dementia, and in determining the risk of disease progression in subjects with mild cognitive impairment (MCI). METHODS: We evaluated the supportive role of CSF Aβ42, t-Tau, p-Tau levels, conventional brain MRI and visual assessment of FDG PET SPM t-maps in the early diagnosis of dementia and the evaluation of MCI progression. RESULTS: Diagnosis based on molecular biomarkers showed the best fit with the final diagnosis at a long follow-up. FDG PET SPM t-maps had the highest diagnostic accuracy in Alzheimer's disease and in the differential diagnosis of non-Alzheimer's disease dementias. The p-tau/Aβ42 ratio was the only CSF biomarker providing a significant classification rate for Alzheimer's disease. An Alzheimer's disease-positive metabolic pattern as shown by FDG PET SPM in MCI was the best predictor of conversion to Alzheimer's disease. CONCLUSION: In this clinical setting, FDG PET SPM t-maps and the p-tau/Aβ42 ratio improved clinical diagnostic accuracy, supporting the importance of these biomarkers in the emerging diagnostic criteria for Alzheimer's disease dementia. FDG PET using SPM t-maps had the highest predictive value by identifying hypometabolic patterns in different neurodegenerative dementias and normal brain metabolism in MCI, confirming its additional crucial exclusionary role.

Published
2015

98. Marinesco-Sjögren syndrome caused by a new SIL1 frameshift mutation

Author

Chiara Cerami a 1, 2, Patrizia Tarantino b 1, Chiara Cupidi a 3, Grazia Annesi b, Vincenzina Lo Re a, 4, Monica Gagliardi b, c, Tommaso Piccoli a, Aldo Quattrone b, Cerami C., Tarantino P., Cupidi C., Annesi G., Lo Re V., Gagliardi M., Piccoli T., and Quattrone A.

Subjects
Neurology, business.industry, Marinesco–Sjögren syndrome, Autosomal recessive cerebellar ataxias, Cerebellar atrophy, Early-onset cataracts, Marinesco-Sjögren Syndrome, Mental retardation, SIL1 gene, Cancer research, Medicine, Cerebellar atrophy, Settore MED/26 - Neurologia, Neurology (clinical), business, medicine.disease, Autosomal recessive cerebellar ataxias, Early-onset cataracts, Marinesco-Sjögren Syndrome, Mental retardation, SIL1 gene, Frameshift mutation
Abstract

no abstract available

Published
2015
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99. Affective mentalizing and brain activity at est in the behavioral variant of frontotemporal dementia

Author

Chiara Crespi, Silvia Paola Caminiti, Chiara Cerami, Andrea Falini, Alessandra Marcone, Stefano F. Cappa, Alessandra Dodich, Sandro Iannaccone, Nicola Canessa, Caminiti, Sp, Canessa, N, Cerami, C, Dodich, A, Crespi, C, Iannaccone, S, Marcone, A, Falini, Andrea, and Cappa, Sf

Subjects
Male, Brain activity and meditation, EA, emotion attribution, Theory of Mind, Resting state functional MRI, Neuropsychological Tests, MMSE, Mini-Mental State Examination, Brain mapping, lcsh:RC346-429, CI, causal inferences, Theory of mind, Image Processing, Computer-Assisted, Aged, 80 and over, Temporal cortex, Brain Mapping, Principal Component Analysis, rs-fMRI, resting-state fMRI, Behavioral variant of frontotemporal dementia, Brain, Regular Article, Cognition, Middle Aged, Magnetic Resonance Imaging, MANCOVAN, multivariate analysis of covariance, aDMN, anterior default mode network, Neurology, Frontotemporal Dementia, lcsh:R858-859.7, Female, AD, Alzheimer's disease, Psychology, Frontotemporal dementia, FDR, false discovery rate, RSNs, resting-state networks, Rest, Cognitive Neuroscience, Affective mentalizing, lcsh:Computer applications to medicine. Medical informatics, FTLD, frontotemporal lobar degeneration, Social cognition, gICA, group independent component analysis, medicine, Humans, Radiology, Nuclear Medicine and imaging, lcsh:Neurology. Diseases of the nervous system, Aged, BOLD, blood-oxygen-level-dependent, PCA, principal component analysis, pDMN, posterior default mode network, Mood Disorders, Executive functioning network, IA, intention attribution, medicine.disease, VBM, voxel based morphometry, Oxygen, SPM, statistical parametric mapping, bvFTD, behavioral variant of frontotemporal dementia, Case-Control Studies, Default mode network, GM, gray matter, ToM, theory of mind, SET, story-based empathy task, Neurology (clinical), Insula, Neuroscience
Abstract

Background bvFTD patients display an impairment in the attribution of cognitive and affective states to others, reflecting GM atrophy in brain regions associated with social cognition, such as amygdala, superior temporal cortex and posterior insula. Distinctive patterns of abnormal brain functioning at rest have been reported in bvFTD, but their relationship with defective attribution of affective states has not been investigated. Objective To investigate the relationship among resting-state brain activity, gray matter (GM) atrophy and the attribution of mental states in the behavioral variant of fronto-temporal degeneration (bvFTD). Methods We compared 12 bvFTD patients with 30 age- and education-matched healthy controls on a) performance in a task requiring the attribution of affective vs. cognitive mental states; b) metrics of resting-state activity in known functional networks; and c) the relationship between task-performances and resting-state metrics. In addition, we assessed a connection between abnormal resting-state metrics and GM atrophy. Results Compared with controls, bvFTD patients showed a reduction of intra-network coherent activity in several components, as well as decreased strength of activation in networks related to attentional processing. Anomalous resting-state activity involved networks which also displayed a significant reduction of GM density. In patients, compared with controls, higher affective mentalizing performance correlated with stronger functional connectivity between medial prefrontal sectors of the default-mode and attentional/performance monitoring networks, as well as with increased coherent activity in components of the executive, sensorimotor and fronto-limbic networks. Conclusions Some of the observed effects may reflect specific compensatory mechanisms for the atrophic changes involving regions in charge of affective mentalizing. The analysis of specific resting-state networks thus highlights an intermediate level of analysis between abnormal brain structure and impaired behavioral performance in bvFTD, reflecting both dysfunction and compensation mechanisms., Highlights • bvFTD patients are impaired in the attribution of mental states to others (theory of mind, ToM). • bvFTD patients' ToM deficit involves mainly the attribution of affective states. • Affective ToM deficits in bvFTD reflect gray matter atrophy in frontolimbic areas. • Affective ToM deficits in bvFTD reflect altered frontomedial resting-state activity. • Brain activity at rest reflects both dysfunction and compensation mechanisms in bvFTD.

Published
2015

100. Brain changes within the visuo-spatial attentional network in posterior cortical atrophy

Author

Chiara Cerami1 2, Chiara Crespi 1, Pasquale Anthony Della Rosa 1, 3, Alessandra Dodich 1, Alessandra Marcone 2, Giuseppe Magnani 4, Elisabetta Coppi 4, Andrea Falini 1, 5, Stefano F. Cappa 1, 2, Daniela Perani1 3, 6, Cerami, C, Crespi, C, Della Rosa, Pa, Dodich, A, Marcone, A, Magnani, G, Coppi, E, Falini, Andrea, Cappa, STEFANO FRANCESCO, and Perani, DANIELA FELICITA L.

Subjects
Male, Neuropsychological Tests, Frontal Eye Field, 0302 clinical medicine, Dementia diagnosis, Cortex (anatomy), Medicine, Cerebral Cortex, 0303 health sciences, General Neuroscience, Superior longitudinal fasciculus, Neurodegenerative Diseases, General Medicine, Frontal eye fields, Middle Aged, Magnetic Resonance Imaging, Psychiatry and Mental health, Clinical Psychology, medicine.anatomical_structure, Diffusion Tensor Imaging, Frontal lobe, Female, Radiology, [18F]FDG-PET Imaging, medicine.medical_specialty, behavioral disciplines and activities, Perceptual Disorders, 03 medical and health sciences, Fluorodeoxyglucose F18, Fractional anisotropy, Humans, 030304 developmental biology, Aged, business.industry, Posterior cortical atrophy, Voxel-based morphometry, Attention Deficit Disorder with Hyperactivity, Positron-Emission Tomography, Space Perception, Posterior Cortical Atrophy, Dementia, Geriatrics and Gerontology, Atrophy, business, Mental Status Schedule, Neuroscience, Voxel-Based Morphometry, 030217 neurology & neurosurgery, Photic Stimulation, Diffusion MRI
Abstract

Posterior Cortical Atrophy (PCA) is characterized by basic visual and high order visual-spatial dysfunctions. In this study, we investigated long-distance deafferentation processes within the frontal-parietal-occipital network in ten PCA patients using a MRI-PET combined approach. Objective voxel-based [18F]FDG-PET imaging measured metabolic changes in single patients. Comprehensive investigation of Diffusion Tensor Imaging (DTI) metrics and grey-matter density with Voxel-based Morphometry (VBM) were obtained in a subgroup of 6 patients. Fractional anisotropy (FA) in the superior longitudinal fasciculus correlated with the PET metabolic changes within the inferior parietal and frontal eye field regions. [18F]FDG-PETanalysis showed in each PCA case the typical bilateral hypometabolic pattern, involving posterior temporal, parietal, and occipital cortex, with additional hypometabolic foci in the frontal eye fields. VBM showed right-sided atrophy in the parieto-occipital cortex, as well as a limited temporal involvement. DTI revealed extensive degeneration of the major anterior-posterior connecting fiber bundles and of commissural frontal lobe tracts. Microstructural measures in the superior longitudinal fasciculus were correlated with the PET metabolic changes within the inferior parietal and frontal eye field regions. Our results confirmed the predominant occipital-temporal and occipital-parietal degeneration in PCA patients. [18F]FDG-PETand DTI-MRI combined approaches revealed neurodegeneration effects well beyond the classical posterior cortical involvement, most likely as a consequence of deafferentation processes within the occipital-parietal-frontal network that could be at the basis of visuo-perceptual, visuo-spatial integration and attention deficits in PCA.&nbsp

Published
2014
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