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547 results on '"Chauvel, Catherine"'

73. Asymmetric sampling in human auditory cortex reveals spectral processing hierarchy

Author

Griffiths, Timothy D., Giroud, Jérémy, Trébuchon, Agnès, Schön, Daniele, Marquis, Patrick, Liegeois-Chauvel, Catherine, Poeppel, David, Morillon, Benjamin, Griffiths, Timothy D., Giroud, Jérémy, Trébuchon, Agnès, Schön, Daniele, Marquis, Patrick, Liegeois-Chauvel, Catherine, Poeppel, David, and Morillon, Benjamin

Abstract

Speech perception is mediated by both left and right auditory cortices but with differential sensitivity to specific acoustic information contained in the speech signal. A detailed description of this functional asymmetry is missing, and the underlying models are widely debated. We analyzed cortical responses from 96 epilepsy patients with electrode implantation in left or right primary, secondary, and/or association auditory cortex (AAC). We presented short acoustic transients to noninvasively estimate the dynamical properties of multiple functional regions along the auditory cortical hierarchy. We show remarkably similar bimodal spectral response profiles in left and right primary and secondary regions, with evoked activity composed of dynamics in the theta (around 4–8 Hz) and beta–gamma (around 15–40 Hz) ranges. Beyond these first cortical levels of auditory processing, a hemispheric asymmetry emerged, with delta and beta band (3/15 Hz) responsivity prevailing in the right hemisphere and theta and gamma band (6/40 Hz) activity prevailing in the left. This asymmetry is also present during syllables presentation, but the evoked responses in AAC are more heterogeneous, with the co-occurrence of alpha (around 10 Hz) and gamma (>25 Hz) activity bilaterally. These intracranial data provide a more fine-grained and nuanced characterization of cortical auditory processing in the 2 hemispheres, shedding light on the neural dynamics that potentially shape auditory and speech processing at different levels of the cortical hierarchy.

Published
2020

74. The different patterns of seizure-induced aphasia in temporal lobe epilepsies

Author

Bonini, Francesca, McGonigal, Aileen, Scavarda, Didier, Carron, Romain, Régis, Jean, Dufour, Henry, Péragut, Jean-Claude, Laguitton, Virginie, Villeneuve, Nathalie, Chauvel, Patrick, Giusiano, Bernard, Trébuchon, Agnès, BARTOLOMEI, Fabrice, LAMBERT, Isabelle, Guisiano, Bernard, Perot, Charline, Liegeois-Chauvel, Catherine, Institut de Neurosciences des Systèmes (INS), and Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Video Recording, Audiology, behavioral disciplines and activities, Speech Disorders, 050105 experimental psychology, Stereoelectroencephalography, Temporal lobe, Young Adult, 03 medical and health sciences, Behavioral Neuroscience, Fluency, Epilepsy, 0302 clinical medicine, Seizures, Aphasia, medicine, Humans, Verbal fluency test, 0501 psychology and cognitive sciences, Ictal, Child, ComputingMilieux_MISCELLANEOUS, Language production, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, 05 social sciences, Electroencephalography, Middle Aged, medicine.disease, Temporal Lobe, nervous system diseases, Epilepsy, Temporal Lobe, nervous system, Neurology, Female, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Objectives Ictal language disturbances may occur in dominant hemisphere temporal lobe epilepsy (TLE), but little is known about the precise anatomoelectroclinical correlations. This study investigated the different facets of ictal aphasia in intracerebrally recorded TLE. Methods Video-stereoelectroencephalography (SEEG) recordings of 37 seizures in 17 right-handed patients with drug-resistant TLE were analyzed; SEEG electroclinical correlations between language disturbance and involvement of temporal lobe structures were assessed. In the clinical analysis, we separated speech disturbance from loss of consciousness. Results According to the region involved, different patterns of ictal aphasia in TLE were identified. Impaired speech comprehension was associated with posterior lateral involvement, anomia and reduced verbal fluency with anterior mediobasal structures, and jargonaphasia with basal temporal involvement. The language production deficits, such as anomia and low fluency, cannot be simply explained by an involvement of Broca's area, since this region was not affected by seizure discharge. Significance Assessment of language function in the early ictal state can be successfully performed and provides valuable information on seizure localization within the temporal lobe as well as potentially useful information for guiding surgery.

Published
2018

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