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52. Dexmedetomidine alleviates cognitive impairment by promoting hippocampal neurogenesis via BDNF/TrkB/CREB signaling pathway in hypoxic–ischemic neonatal rats

Author

Chen, Xiaohui, primary, Chen, Andi, additional, Wei, Jianjie, additional, Huang, Yongxin, additional, Deng, Jianhui, additional, Chen, Pinzhong, additional, Yan, Yanlin, additional, Lin, Mingxue, additional, Chen, Lifei, additional, Zhang, Jiuyun, additional, Huang, Zhibin, additional, Zeng, Xiaoqian, additional, Gong, Cansheng, additional, and Zheng, Xiaochun, additional

Published
2023
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59. Large Scale UAVs Collaborative Formation Simulation Based on Starlings’ Flight Mechanism

Author

Xie, Rong, Gu, Cunfeng, Liu, Li, Chen, Lifei, Zhang, Linyu, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, U, Leong Hou, editor, and Xie, Haoran, editor

Published
2018
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60. Sequence-As-Feature Representation for Subspace Classification of Multivariate Time Series

Author

Yuan, Liang, Chen, Lifei, Xie, Rong, Hsu, Huihuang, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, U, Leong Hou, editor, and Xie, Haoran, editor

Published
2018
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61. A Self-representation Model for Robust Clustering of Categorical Sequences

Author

Xu, Kunpeng, Chen, Lifei, Wang, Shengrui, Wang, Beizhan, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, U, Leong Hou, editor, and Xie, Haoran, editor

Published
2018
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63. Preparation and Characterization of Nitride Ceramic Thermal Conductive Fillers Decorated with Metal Nanoparticles.

Author

CHEN Yanjie, DONG Huarui, MA Qingyi, ZHAO Xueling, and CHEN Lifei

Abstract

Nitride thermal conductive composite fillers were prepared by the mix and heat method. It's an environmentally friendly preparation method that can be mass-produced and does not use solvents. The loading of different metal nanoparticles (nickel, cobalt and silver) onto nitrides (aluminum nitride, boron nitride) and the amount of loading were investigated by scanning electron microscopy, X-ray diffractometer and TCI thermal conductivity meter, and the effect of composite ceramic thermally conductive filler on the thermal conductivity of polyvinyl alcohol-based composite thermal conductive film was examined. The results show that the metal nanoparticles were successfully loaded onto the nitrides without changing the crystal structure of the nitrides. And the size of the loaded metal particles increase with the increase of acetate content. In addition, the ceramic thermally conductive filler loaded with metal particles can effectively improve the thermal conductivity of polyvinyl alcohol-based composite thermally conductive film, and the thermal conductivity of Ag/AlN-0.05 thermally conductive film can reach 0.752 W/(m⋅K). [ABSTRACT FROM AUTHOR]

Published
2024
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64. Dexmedetomidine alleviates cognitive impairment by promoting hippocampal neurogenesis via BDNF/TrkB/CREB signaling pathway in hypoxic–ischemic neonatal rats.

Author

Chen, Xiaohui, Chen, Andi, Wei, Jianjie, Huang, Yongxin, Deng, Jianhui, Chen, Pinzhong, Yan, Yanlin, Lin, Mingxue, Chen, Lifei, Zhang, Jiuyun, Huang, Zhibin, Zeng, Xiaoqian, Gong, Cansheng, and Zheng, Xiaochun

Subjects
BRAIN-derived neurotrophic factor, COGNITION disorders, DENTATE gyrus, NEUROGENESIS, CELLULAR signal transduction
Abstract

Aims: Dexmedetomidine (DEX) has been reported to alleviate hypoxic–ischemic brain damage (HIBD) in neonates. This study aimed to investigate whether DEX improves cognitive impairment by promoting hippocampal neurogenesis via the BDNF/TrkB/CREB signaling pathway in neonatal rats with HIBD. Methods: HIBD was induced in postnatal day 7 rats using the Rice‐Vannucci method, and DEX (25 μg/kg) was administered intraperitoneally immediately after the HIBD induction. The BDNF/TrkB/CREB pathway was regulated by administering the TrkB receptor antagonist ANA‐12 through intraperitoneal injection or by delivering adeno‐associated virus (AAV)‐shRNA‐BDNF via intrahippocampal injection. Western blot was performed to measure the levels of BDNF, TrkB, and CREB. Immunofluorescence staining was utilized to identify the polarization of astrocytes and evaluate the levels of neurogenesis in the dentate gyrus of the hippocampus. Nissl and TTC staining were performed to evaluate the extent of neuronal damage. The MWM test was conducted to evaluate spatial learning and memory ability. Results: The levels of BDNF and neurogenesis exhibited a notable decrease in the hippocampus of neonatal rats after HIBD, as determined by RNA‐sequencing technology. Our results demonstrated that treatment with DEX effectively increased the protein expression of BDNF and the phosphorylation of TrkB and CREB, promoting neurogenesis in the dentate gyrus of the hippocampus in neonatal rats with HIBD. Specifically, DEX treatment significantly augmented the expression of BDNF in hippocampal astrocytes, while decreasing the proportion of detrimental A1 astrocytes and increasing the proportion of beneficial A2 astrocytes in neonatal rats with HIBD. Furthermore, inhibiting the BDNF/TrkB/CREB pathway using either ANA‐12 or AAV‐shRNA‐BDNF significantly counteracted the advantageous outcomes of DEX on hippocampal neurogenesis, neuronal survival, and cognitive improvement. Conclusions: DEX promoted neurogenesis in the hippocampus by activating the BDNF/TrkB/CREB pathway through the induction of polarization of A1 astrocytes toward A2 astrocytes, subsequently mitigating neuronal damage and cognitive impairment in neonates with HIBD. [ABSTRACT FROM AUTHOR]

Published
2024
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66. An Adversarial Machine Learning Model Against Android Malware Evasion Attacks

Author

Chen, Lingwei, Hou, Shifu, Ye, Yanfang, Chen, Lifei, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Song, Shaoxu, editor, Renz, Matthias, editor, and Moon, Yang-Sae, editor

Published
2017
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67. Deep Analysis and Utilization of Malware’s Social Relation Network for Its Detection

Author

Hou, Shifu, Chen, Lingwei, Ye, Yanfang, Chen, Lifei, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Song, Shaoxu, editor, Renz, Matthias, editor, and Moon, Yang-Sae, editor

Published
2017
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68. Smooth Representation Clustering Based on Kernelized Random Walks

Author

Chen, Liping, Guo, Gongde, Chen, Lifei, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Song, Shaoxu, editor, Renz, Matthias, editor, and Moon, Yang-Sae, editor

Published
2017
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71. Clustering Categorical Sequences with Variable-Length Tuples Representation

Author

Yuan, Liang, Hong, Zhiling, Chen, Lifei, Cai, Qiang, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Lehner, Franz, editor, and Fteimi, Nora, editor

Published
2016
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72. DroidDelver: An Android Malware Detection System Using Deep Belief Network Based on API Call Blocks

Author

Hou, Shifu, Saas, Aaron, Ye, Yanfang, Chen, Lifei, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Song, Shaoxu, editor, and Tong, Yongxin, editor

Published
2016
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77. Subspace Clustering on Mobile Data for Discovering Circle of Friends

Author

Wu, Tao, Fan, Yujie, Hong, Zhiling, Chen, Lifei, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Weikum, Gerhard, Series Editor, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Zhang, Songmao, editor, Wirsing, Martin, editor, and Zhang, Zili, editor

Published
2015
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89. Centroid-Based Classification of Categorical Data

Author

Chen, Lifei, Guo, Gongde, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Kobsa, Alfred, editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Weikum, Gerhard, editor, Li, Feifei, editor, Li, Guoliang, editor, Hwang, Seung-won, editor, Yao, Bin, editor, and Zhang, Zhenjie, editor

Published
2014
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97. Syringa oblata genome provides new insights into molecular mechanism of flower color differences among individuals and biosynthesis of its flower volatiles

Author

Chen, Lifei, primary, Xia, Bin, additional, Li, Ziwei, additional, Liu, Xiaowei, additional, Bai, Yun, additional, Yang, Yujia, additional, Gao, Wenjie, additional, Meng, Qingran, additional, Xu, Ning, additional, Sun, Ying, additional, Li, Qiang, additional, Yue, Liran, additional, He, Miao, additional, and Zhou, Yunwei, additional

Published
2022
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