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52. Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition

Author

Clasen, Joanna L., Mabunda, Rita, Heath, Alicia K., Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Birukov, Anna, Tagliabue, Giovanna, Chiodini, Paolo, Tumino, Rosario, Milani, Lorenzo, Braaten, Tonje, Gram, Inger, Lukic, Marko, Luján-Barroso, Leila, Rodriguez-Barranco, Miguel, Chirlaque, María-Dolores, Ardanaz, Eva, Amiano, Pilar, Manjer, Jonas, Huss, Linnea, Ljungberg, Börje, Travis, Ruth, Smith-Byrne, Karl, Gunter, Marc, Johansson, Matthias, Rinaldi, Sabina, Weiderpass, Elisabete, Riboli, Elio, Cross, Amanda J., and Muller, David C.

Subjects
Cancer och onkologi, Cancer and Oncology, 1112 Oncology and Carcinogenesis, 0601 Biochemistry and Cell Biology
Abstract

Background: Renal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology. Materials & Methods: We investigated associations of age at menarche and age at menopause, pregnancy-related factors, hysterectomy and ovariectomy and exogenous hormone use with RCC risk among 298,042 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Results: During 15 years of follow-up, 438 RCC cases were identified. Parous women had higher rates of RCC compared with nulliparous women (HR = 1.71, 95% CI 1.18, 2.46), and women who were older at age of first pregnancy had lower rates of RCC (30 years + vs.

Published
2023

53. CD39 affects the prognostic role of NLR via N2 neutrophils in metastatic melanoma patients treated with immunotherapy

Author

Mallardo Domenico, Fordellone Mario, White Andrew, Margaret, Ottaviano, Sparano Francesca, Michael, Bailey, Facchini Arianna, Ong SuFey, Maiolino Piera, Caracò Corrado, Church Sarah, Cavalcanti Ernesta, Sarah, Warren, Budillon Alfredo, Cesano Alessandra, Ester, Simeone, Chiodini Paolo, and Ascierto Paolo Antonio

Abstract

The immune checkpoint inhibitors (ICIs) revolutionized cancer therapeutic landscape and substantially improved the survival of patients (pts) with advanced malignancies. Several predictive biomarkers are under evaluation, in order to identify patients who can benefit from ICI. Recently, elevated NLR, calculated from absolute neutrophil count and white cell count, were found to be independent predictors of reduced survival and increased risk of progression in melanoma patients receiving ICI. The purpose of this study is to retrospectively investigate relationship of NLR with inflammation-immune mediators.The immune checkpoint inhibitors (ICIs) revolutionized cancer therapeutic landscape and substantially improved the survival of patients (pts) with advanced malignancies. Several predictive biomarkers are under evaluation, in order to identify patients who can benefit from ICI. Recently, elevated NLR, calculated from absolute neutrophil count and white cell count, were found to be independent predictors of reduced survival and increased risk of progression in melanoma patients receiving ICI. The purpose of this study is to retrospectively investigate relationship of NLR with inflammation-immune mediators.

Published
2023
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56. Abiraterone Acetate for Treatment of Metastatic Castration-resistant Prostate Cancer in Chemotherapy-naive Patients: An Italian Analysis of Patients' Satisfaction

Author

Cindolo, Luca, Natoli, Clara, De Nunzio, Cosimo, De Tursi, Michele, Valeriani, Maurizio, Giacinti, Silvana, Micali, Salvatore, Rizzo, Mino, Bianchi, Giampaolo, Martorana, Eugenio, Scarcia, Marcello, Ludovico, Giuseppe Mario, Bove, Pierluigi, Laudisi, Anastasia, Selvaggio, Oscar, Carrieri, Giuseppe, Bada, Maida, Castellan, Pietro, Topazio, Luca, Boccasile, Stefano, Ditonno, Pasquale, Chiodini, Paolo, and Schips, Luigi

Published
2017
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57. Carboplatin and paclitaxel plus avelumab compared with carboplatin and paclitaxel in advanced or recurrent endometrial cancer (MITO END-3): a multicentre, open-label, randomised, controlled, phase 2 trial

Author

Pignata, Sandro, primary, Scambia, Giovanni, additional, Schettino, Clorinda, additional, Arenare, Laura, additional, Pisano, Carmela, additional, Lombardi, Davide, additional, De Giorgi, Ugo, additional, Andreetta, Claudia, additional, Cinieri, Saverio, additional, De Angelis, Carmine, additional, Priolo, Domenico, additional, Casanova, Claudia, additional, Rosati, Marta, additional, Greco, Filippo, additional, Zafarana, Elena, additional, Schiavetto, Ilaria, additional, Mammoliti, Serafina, additional, Cecere, Sabrina Chiara, additional, Salutari, Vanda, additional, Scalone, Simona, additional, Farolfi, Alberto, additional, Di Napoli, Marilena, additional, Lorusso, Domenica, additional, Gargiulo, Piera, additional, Califano, Daniela, additional, Russo, Daniela, additional, Spina, Anna, additional, De Cecio, Rossella, additional, Chiodini, Paolo, additional, Perrone, Francesco, additional, Accinno, Valentina, additional, Altavilla, Chiara, additional, Antonelli, Giovanna, additional, Artioli, Grazia, additional, Avola, Francesco, additional, Barbara, Bonifacio, additional, Barbato, Valentina, additional, Bartoletti, Michele, additional, Bevilacqua, Simona, additional, Bordonaro, Roberto, additional, Borghese, Oriana, additional, Buonfanti, Gaetano, additional, Camarda, Floriana, additional, Canzanella, Giuliana, additional, Carbone, Vittoria, additional, Carbone, Maria Rita, additional, Carlo Stella, Giulia, additional, Cassani, Chiara, additional, Castagna, Fabrizio, additional, Cattaneo, Monica, additional, Cinefra, Margherita, additional, Colombo, Nicoletta, additional, Corsetti, Serena, additional, Dall'Agata, Monia, additional, D'Amico, Maria, additional, Daniele, Gennaro, additional, De Marino, Elvira, additional, De Matteis, Giovanni, additional, De Placido, Sabino, additional, Del Bene, Gabriella, additional, Del Giudice, Antonia, additional, Del Monte, Francesca, additional, Del Sesto, Michele, additional, Donini, Maddalena, additional, Drudi, Giuliana, additional, Falcone, Gianluca, additional, Favaretto, Adolfo, additional, Ferrera, Giulia, additional, Florio, Manuela, additional, Forestieri, Valeria, additional, Gallo, Maria Stella, additional, Gallo, Ciro, additional, Garibaldi, Francesca, additional, Gerevini, Fabiana, additional, Ghizzoni, Viola, additional, Giganti, Maria Olga, additional, Gimigliano, Anna, additional, Giudice, Elena, additional, Gnocchi, Nicoletta, additional, Gravina, Adriano, additional, Greggi, Stefano, additional, Iaia, Maria Laura, additional, Ilardi, Annalisa, additional, Iovine, Gelsomina, additional, Ippoliti, Gabriella, additional, Irollo, Giulia, additional, Isidori, Ilenia, additional, Lapresa, Mariateresa, additional, Lavenia, Giuseppe, additional, Longhitano, Laura, additional, Lucia, Bortot, additional, Luzi, Gabriella, additional, Mariano, Sara, additional, Marino, Valentina, additional, Marrapese, Giovanna, additional, Martino, Marilena, additional, Matocci, Roberta, additional, Mazzoni, Enrica, additional, Mercuri, Daniela, additional, Mirto, Maria, additional, Mollo, Giovanna, additional, Montinaro, Abbondanza, additional, Moscatelli, Marta, additional, Mosconi, Anna Maria, additional, Musacchio, Lucia, additional, Nanni, Nicoletta, additional, Natalucci, Pamela, additional, Nicoloso, Milena Sabrina, additional, Orditura, Michele, additional, Parma, Gabriella Maria, additional, Passalacqua, Rodolfo, additional, Pelone, Michela, additional, Perri, Maria Teresa, additional, Perrucci, Bruno, additional, Piancastelli, Alessandra, additional, Piccirillo, Maria Carmela, additional, Piccolo, Antonio, additional, Pignata, Sandro, additional, Rapisardi, Stefania, additional, Ravaglia, Giorgia, additional, Ribecco, Teresa, additional, Ricci, Caterina, additional, Roccio, Marianna, additional, Romano, Fiorella, additional, Sambataro, Daniela, additional, Savio, Alfonso, additional, Sbriglia, Ada, additional, Scaffa, Cono, additional, Sergi, Concetta, additional, Sgandurra, Francesca, additional, Sorio, Roberto, additional, Stabile, Stefano, additional, Tabaro, Gianna, additional, Tambaro, Margherita, additional, Tamberi, Stefano, additional, Tecchiato, Angelica, additional, Trujillo, Angela Maria, additional, and Zaccarelli, Eleonora, additional

Published
2023
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60. Sex difference in cardiovascular risk in patients with chronic kidney disease: pooled analysis of four cohort studies.

Author

Borrelli, Silvio, Garofalo, Carlo, Gabbai, Francis B, Liberti, Maria Elena, Chiodini, Paolo, Simeon, Vittorio, Nicola, Luca De, Minutolo, Roberto, and Nephrology, for the Collaborative Study Group on the Conservative Treatment of CKD of the Italian Society of

Subjects
CHRONIC kidney failure, CARDIOVASCULAR diseases risk factors, CHRONICALLY ill, LEFT ventricular hypertrophy, SYSTOLIC blood pressure
Abstract

Background Progression of chronic kidney disease (CKD) has proven to be faster in men than in women. Whether the same holds true for cardiovascular risk remains ill-defined. Methods We conducted a pooled analysis of four cohort studies from 40 nephrology clinics in Italy including patients with CKD [estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 or higher if proteinuria >0.15 g/day]. The aim was to compare multivariable-adjusted risk (hazard ratio, 95% confidence interval) of a composite cardiovascular endpoint (cardiovascular death and non-fatal myocardial infarction, congestive heart failure, stroke, revascularization, peripheral vascular disease and non-traumatic amputation) in women (n  = 1192) versus men (n  = 1635). Results At baseline, women had slightly higher systolic blood pressure (SBP) as compared with men (139 ± 19 vs 138 ± 18 mmHg, P  = .049), lower eGFR (33.4 vs 35.7 mL/min/1.73 m2, P  = .001) and lower urine protein excretion (0.30 g/day vs 0.45 g/day in men, P  < .001). Women did not differ from men in age and prevalence of diabetes, while having a lower prevalence of cardiovascular disease, left ventricular hypertrophy and smoking habit. During a median follow-up of 4.0 years, 517 fatal and non-fatal cardiovascular events were registered (199 in women and 318 in men). The adjusted risk of cardiovascular events was lower in women (0.73, 0.60–0.89, P  = .002) than in men; however, the cardiovascular risk advantage of women progressively diminished as SBP (as continuous variable) increased (P for interaction = .021). Similar results were obtained when considering SBP categories: when compared with men, women had lower cardiovascular risk for SBP <130 mmHg (0.50, 0.31–0.80, P  = .004) and SBP 130–140 mmHg (0.72, 0.53–0.99, P  = .038), while no difference was observed for SBP >140 mmHg (0.85, 0.64–1.11, P  = .232). Conclusions Higher BP levels abolish the cardiovascular protection seen in female vs male patients with overt CKD. This finding supports the need for higher awareness of hypertensive burden in women with CKD. [ABSTRACT FROM AUTHOR]

Published
2023
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61. Machine Learning Application Identifies Germline Markers of Hypertension in Patients With Ovarian Cancer Treated With Carboplatin, Taxane, and Bevacizumab.

Author

Polano, Maurizio, Bedon, Luca, Dal Bo, Michele, Sorio, Roberto, Bartoletti, Michele, De Mattia, Elena, Cecchin, Erika, Pisano, Carmela, Lorusso, Domenica, Lissoni, Andrea Alberto, De Censi, Andrea, Cecere, Sabrina Chiara, Scollo, Paolo, Marchini, Sergio, Arenare, Laura, De Giorgi, Ugo, Califano, Daniela, Biagioli, Elena, Chiodini, Paolo, and Perrone, Francesco

Subjects
OVARIAN cancer, CANCER patients, MACHINE learning, HYPERTENSION, BEVACIZUMAB, GENETIC variation, PRECISION farming
Abstract

Pharmacogenomics studies how genes influence a person's response to treatment. When complex phenotypes are influenced by multiple genetic variations with little effect, a single piece of genetic information is often insufficient to explain this variability. The application of machine learning (ML) in pharmacogenomics holds great potential — namely, it can be used to unravel complicated genetic relationships that could explain response to therapy. In this study, ML techniques were used to investigate the relationship between genetic variations affecting more than 60 candidate genes and carboplatin‐induced, taxane‐induced, and bevacizumab‐induced toxicities in 171 patients with ovarian cancer enrolled in the MITO‐16A/MaNGO‐OV2A trial. Single‐nucleotide variation (SNV, formerly SNP) profiles were examined using ML to find and prioritize those associated with drug‐induced toxicities, specifically hypertension, hematological toxicity, nonhematological toxicity, and proteinuria. The Boruta algorithm was used in cross‐validation to determine the significance of SNVs in predicting toxicities. Important SNVs were then used to train eXtreme gradient boosting models. During cross‐validation, the models achieved reliable performance with a Matthews correlation coefficient ranging from 0.375 to 0.410. A total of 43 SNVs critical for predicting toxicity were identified. For each toxicity, key SNVs were used to create a polygenic toxicity risk score that effectively divided individuals into high‐risk and low‐risk categories. In particular, compared with low‐risk individuals, high‐risk patients were 28‐fold more likely to develop hypertension. The proposed method provided insightful data to improve precision medicine for patients with ovarian cancer, which may be useful for reducing toxicities and improving toxicity management. [ABSTRACT FROM AUTHOR]

Published
2023
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66. Dipping Status, Ambulatory Blood Pressure Control, Cardiovascular Disease, and Kidney Disease Progression: A Multicenter Cohort Study of CKD

Author

Borrelli, Silvio, primary, Garofalo, Carlo, additional, Gabbai, Francis B., additional, Chiodini, Paolo, additional, Signoriello, Simona, additional, Paoletti, Ernesto, additional, Ravera, Maura, additional, Bussalino, Elisabetta, additional, Bellizzi, Vincenzo, additional, Liberti, Maria Elena, additional, De Nicola, Luca, additional, and Minutolo, Roberto, additional

Published
2023
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67. Effectiveness of Switch to Erythropoiesis-Stimulating Agent (ESA) Biosimilars versus Maintenance of ESA Originators in the Real-Life Setting: Matched-Control Study in Hemodialysis Patients

Author

Minutolo, Roberto, Bolasco, Piergiorgio, Chiodini, Paolo, Sposini, Stefano, Borzumati, Maurizio, Abaterusso, Cataldo, Mele, Alessandra A., Santoro, Domenico, Canale, Valeria, Santoboni, Alberto, Filiberti, Oliviero, Fiorini, Fulvio, Mura, Carlo, Imperiali, Patrizio, Borrelli, Silvio, Russo, Luigi, De Nicola, Luca, and Russo, Domenico

Published
2017
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69. Global psychological assessment with the evaluation of life and sleep quality and sexual and cognitive function in a large number of patients with acromegaly: a cross-sectional study

Author

Pivonello, Rosario, primary, Auriemma, Renata Simona, additional, Delli Veneri, Alessandra, additional, Dassie, Francesca, additional, Lorusso, Riccardina, additional, Ragonese, Marta, additional, Liotta, Marco, additional, Sala, Elisa, additional, Zarino, Barbara, additional, Lai, Elisa, additional, Urbani, Claudio, additional, Bogazzi, Fausto, additional, Mantovani, Giovanna, additional, Cannavò, Salvatore, additional, Maffei, Pietro, additional, Chiodini, Paolo, additional, and Colao, Annamaria, additional

Published
2022
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71. Chocolate Eaters Do Not Necessarily Win a Nobel Prize--Authors in Special Issues Do Not Necessarily Publish Lower Quality Papers.

Author

Künzli, Nino, Woodrow, Christopher, Berger, Anke, Czabanowska, Katarzyna, Iacoviello, Licia, Lucas, Raquel, Geckova, Andrea Madarasova, Merten, Sonja, von dem Knesebeck, Olaf, Mantwill, Sarah, Panico, Salvatore, Osorio, Lyda, Ribeiro, Ana Isabel, Chiodini, Paolo, Suggs, L. Suzanne, and Coulibaly, Jean

Subjects
CHOCOLATE, OPEN access publishing, COVID-19 pandemic, NOBEL Prizes, EDITORIAL policies
Published
2024
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72. Mediterranean Dietary Pattern and Chronic Diseases

Author

Panico, Salvatore, Mattiello, Amalia, Panico, Camilla, Chiodini, Paolo, Rosen, Steven T., Series editor, Zappia, Vincenzo, editor, Panico, Salvatore, editor, Russo, Gian Luigi, editor, Budillon, Alfredo, editor, and Della Ragione, Fulvio, editor

Published
2014
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76. Analysis of A Disintegrin and Metalloprotease 17 (ADAM17) Expression as a Prognostic Marker in Ovarian Cancer Patients Undergoing First-Line Treatment Plus Bevacizumab

Author

Fabbi, Marina, primary, Costa, Delfina, additional, Russo, Daniela, additional, Arenare, Laura, additional, Gaggero, Gabriele, additional, Signoriello, Simona, additional, Scambia, Giovanni, additional, Pisano, Carmela, additional, Colombo, Nicoletta, additional, Losito, Nunzia Simona, additional, Filaci, Gilberto, additional, Spina, Anna, additional, Califano, Daniela, additional, Scognamiglio, Giosuè, additional, Gadducci, Angiolo, additional, Mezzanzanica, Delia, additional, Bagnoli, Marina, additional, Ferrini, Silvano, additional, Canzonieri, Vincenzo, additional, Chiodini, Paolo, additional, Perrone, Francesco, additional, and Pignata, Sandro, additional

Published
2022
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77. Composite urinary and sexual outcomes after Rezum: an analysis of predictive factors from an Italian multi-centric study

Author

Campobasso, Davide, primary, Siena, Giampaolo, additional, Chiodini, Paolo, additional, Conti, Enrico, additional, Franzoso, Francesco, additional, Maruzzi, Daniele, additional, Martinelli, Evangelista, additional, Varvello, Francesco, additional, De Nunzio, Cosimo, additional, Autorino, Riccardo, additional, Somani, Bhaskar Kumar, additional, Ferrari, Giovanni, additional, and Cindolo, Luca, additional

Published
2022
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78. Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort ( EPIC )

Author

Mahamat‐Saleh, Yahya, primary, Al‐Rahmoun, Marie, additional, Severi, Gianluca, additional, Ghiasvand, Reza, additional, Veierod, Marit B., additional, Caini, Saverio, additional, Palli, Domenico, additional, Botteri, Edoardo, additional, Sacerdote, Carlotta, additional, Ricceri, Fulvio, additional, Lukic, Marko, additional, Sánchez, Maria J., additional, Pala, Valeria, additional, Tumino, Rosario, additional, Chiodini, Paolo, additional, Amiano, Pilar, additional, Colorado‐Yohar, Sandra, additional, Chirlaque, María‐Dolores, additional, Ardanaz, Eva, additional, Bonet, Catalina, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Schulze, Matthias B., additional, Overvad, Kim, additional, Dahm, Christina C., additional, Antoniussen, Christian S., additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Bueno‐de‐Mesquita, Bas, additional, Manjer, Jonas, additional, Jansson, Malin, additional, Esberg, Anders, additional, Mori, Nagisa, additional, Ferrari, Pietro, additional, Weiderpass, Elisabete, additional, Boutron‐Ruault, Marie‐Christine, additional, and Kvaskoff, Marina, additional

Published
2022
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85. Association between Renal Function at Admission and COVID-19 in-Hospital Mortality in Southern Italy: Findings from the Prospective Multicenter Italian COVOCA Study

Author

Galiero, Raffaele, Simeon, Vittorio, Loffredo, Giuseppe, Caturano, Alfredo, Rinaldi, Luca, Vetrano, Erica, Medicamento, Giulia, Alfano, Maria, Beccia, Domenico, Brin, Chiara, Colantuoni, Sara, Di Salvo, Jessica, Epifani, Raffaella, Nevola, Riccardo, Marfella, Raffaele, Sardu, Celestino, Coppola, Carmine, Scarano, Ferdinando, Maggi, Paolo, Calabrese, Cecilia, De Lucia Sposito, Pellegrino, Rescigno, Carolina, Sbreglia, Costanza, Fraganza, Fiorentino, Parrella, Roberto, Romano, Annamaria, Calabria, Giosuele, Polverino, Benedetto, Pagano, Antonio, Numis, Fabio Giuliano, Bologna, Carolina, Nunziata, Mariagrazia, Esposito, Vincenzo, Coppola, Nicola, Maturo, Nicola, Nasti, Rodolfo, Di Micco, Pierpaolo, Perrella, Alessandro, Lettieri, Miriam, Adinolfi, Luigi Elio, Chiodini, Paolo, Sasso, Ferdinando Carlo, On Behalf Of Covoca Study Group, null, Galiero, Raffaele, Simeon, Vittorio, Loffredo, Giuseppe, Caturano, Alfredo, Rinaldi, Luca, Vetrano, Erica, Medicamento, Giulia, Alfano, Maria, Beccia, Domenico, Brin, Chiara, Colantuoni, Sara, Di Salvo, Jessica, Epifani, Raffaella, Nevola, Riccardo, Marfella, Raffaele, Sardu, Celestino, Coppola, Carmine, Scarano, Ferdinando, Maggi, Paolo, Calabrese, Cecilia, De Lucia Sposito, Pellegrino, Rescigno, Carolina, Sbreglia, Costanza, Fraganza, Fiorentino, Parrella, Roberto, Romano, Annamaria, Calabria, Giosuele, Polverino, Benedetto, Pagano, Antonio, Numis, Fabio Giuliano, Bologna, Carolina, Nunziata, Mariagrazia, Esposito, Vincenzo, Coppola, Nicola, Maturo, Nicola, Nasti, Rodolfo, Di Micco, Pierpaolo, Perrella, Alessandro, Lettieri, Miriam, Adinolfi, Luigi Elio, Chiodini, Paolo, Sasso, Ferdinando Carlo, and On Behalf Of Covoca Study Group, Null

Subjects
COVID-19, chronic kidney diseases, in-hospital mortality, General Medicine, chronic kidney disease
Abstract

Background. Evidence has shown a close association between COVID-19 infection and renal complications in both individuals with previously normal renal function and those with chronic kidney disease (CKD). Methods. The aim of this study is to evaluate the in-hospital mortality of SARS-CoV-2 patients according to their clinical history of CKD or estimated glomerular filtration rate (eGFR). This is a prospective multicenter observational cohort study which involved adult patients (≥18 years old) who tested positive with SARS-CoV-2 infection and completed their hospitalization in the period between November 2020 and June 2021. Results. 1246 patients were included in the study, with a mean age of 64 years (SD 14.6) and a median duration of hospitalization of 15 days (IQR 9–22 days). Cox’s multivariable regression model revealed that mortality risk was strongly associated with the stage of renal impairment and the Kaplan–Meier survival analysis showed a progressive and statistically significant difference (p < 0.0001) in mortality according to the stage of CKD. Conclusion. This study further validates the association between CKD stage at admission and mortality in patients hospitalized for COVID-19. The risk stratification based on eGFR allows clinicians to identify the subjects with the highest risk of intra-hospital mortality despite the duration of hospitalization.

Published
2022

87. A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events

Author

Cappozzo, Andrea, primary, McCrory, Cathal, additional, Robinson, Oliver, additional, Sterrantino, Anna Freni, additional, Sacerdote, Carlotta, additional, Krogh, Vittorio, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Iacoviello, Licia, additional, Ricceri, Fulvio, additional, Sieri, Sabina, additional, Chiodini, Paolo, additional, Kenny, Rose Anne, additional, O’Halloran, Aisling, additional, Polidoro, Silvia, additional, Solinas, Giuliana, additional, Vineis, Paolo, additional, Ieva, Francesca, additional, and Fiorito, Giovanni, additional

Published
2022
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89. The bidirectional relationship between testosterone and metabolic disorders: testosterone deficiency as an early marker of cardiovascular risk in young men

Author

Menafra, Davide, primary, De, Angelis Cristina, additional, Garifalos, Francesco, additional, Castoro, Michele, additional, Verde, Nunzia, additional, Piscopo, Mariangela, additional, Galdiero, Giacomo, additional, Pivonello, Claudia, additional, Simona, Auriemma Renata, additional, Chiodini, Paolo, additional, Colao, Annamaria, additional, and Pivonello, Rosario, additional

Published
2022
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90. Morphostructural characterization of the testis in a large cohort of men living in highly polluted areas of Campania Region in south Italy: a focus on cadmium exposure

Author

Garifalos, Francesco, primary, De, Angelis Cristina, additional, Di, Nunzio Aldo, additional, Menafra, Davide, additional, Castoro, Michele, additional, Verde, Nunzia, additional, Galdiero, Giacomo, additional, Piscopo, Mariangela, additional, Pivonello, Claudia, additional, Auriemma, Renata Simona, additional, Chiodini, Paolo, additional, Trifuoggi, Marco, additional, Colao, Annamaria, additional, and Pivonello, Rosario, additional

Published
2022
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91. MO092: Prevalence and Renal Prognosis of Left Ventricular Diastolic Dysfunction in Nondialysis Chronic Kidney Disease Patients With Preserved Systolic Function

Author

Borrelli, Silvio, primary, De Nicola, Luca, additional, Garofalo, Carlo, additional, Lembo, Eugenio, additional, Netti, Antonella, additional, Lucà, Sergio, additional, Lucà, Stefano, additional, Chiodini, Paolo, additional, Paoletti, Ernesto, additional, Stanzione, Giovanna, additional, Conte, Giuseppe, additional, and Minutolo, Roberto, additional

Published
2022
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92. No additional benefit of prescribing a very low-protein diet in patients with advanced chronic kidney disease under regular nephrology care: a pragmatic, randomized, controlled trial

Author

Bellizzi, Vincenzo, primary, Signoriello, Simona, additional, Minutolo, Roberto, additional, Di Iorio, Biagio, additional, Nazzaro, Paola, additional, Garofalo, Carlo, additional, Calella, Patrizia, additional, Chiodini, Paolo, additional, and De Nicola, Luca, additional

Published
2022
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95. Prognostic value of clinical, echocardiographic and angiographic indicators in patients with large anterior ST-segment elevation myocardial infarction as a first acute coronary event

Author

Baldi, Cesare, Polito, Maria V., Citro, Rodolfo, Farina, Rosario, Attisano, Tiziana, Mirra, Marco, Chiodini, Paolo, Di Muro, Michele R., Di Maio, Marco, Vigorito, Francesco, De Vecchis, Renato, Bossone, Eduardo, Piscione, Federico, Giudice, Pietro, and Galasso, Gennaro

Published
2017
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97. Risk of end-stage kidney disease in kidney transplant recipients versus patients with native chronic kidney disease: multicentre unmatched and propensity-score matched analyses.

Author

Nicola, Luca De, Serra, Raffaele, Provenzano, Michele, Minutolo, Roberto, Michael, Ashour, Ielapi, Nicola, Federico, Stefano, Carrano, Rosa, Bellizzi, Vincenzo, Garofalo, Carlo, Iodice, Carmela, Borrelli, Silvio, Grandaliano, Giuseppe, Stallone, Giovanni, Gesualdo, Loreto, Chiodini, Paolo, and Andreucci, Michele

Subjects
CHRONIC kidney failure, DISEASE risk factors, KIDNEY diseases, KIDNEY transplantation, SYSTOLIC blood pressure
Abstract

Background In kidney transplant recipients (KTR), the end-stage kidney disease (ESKD) risk dependent on the risk factors acting in native chronic kidney disease (CKD) remains undefined. Methods We compared risk and determinants of ESKD between 757 adult KTR and 1940 patients with native CKD before and after propensity-score (PS) analysis matched for unmodifiable risk factors [(age, sex, diabetes, cardiovascular disease and estimated glomerular filtration rate (eGFR)]. Results In unmatched cohorts, eGFR was lower in CKD versus KTR (45.9 ± 11.3 versus 59.2 ± 13.4 mL/min/1.73 m2, P < 0.001). During a median follow-up of 5.4 years, the unadjusted cumulative incidence of ESKD was consistently lower in unmatched KTR versus CKD. Conversely, in PS-matched analysis, the risk of ESKD in KTR was 78% lower versus CKD at 1 year of follow-up while progressively increased over time resulting similar to that of native CKD patients after 5 years and 2.3-fold higher than that observed in CKD at 10 years. R2 analysis in unmatched patients showed that the proportion of the outcome variance explained by traditional ESKD determinants was smaller in KTR versus native CKD (31% versus 70%). After PS matching, the risk of ESKD [hazard ratio (HR), 95% confidence interval (95% CI)] was significantly associated with systolic blood pressure (1.02, 1.01–1.02), phosphorus (1.31, 1.05–1.64), 24-h proteinuria (1.11, 1.05–1.17) and haemoglobin (0.85, 0.78–0.93) irrespective of KTR status. Similar data were obtained after matching also for modifiable risk factors. Conclusions In KTR, when compared with matched native CKD patients, the risk of ESKD is lower in the first 5 years and higher later on. Traditional determinants of ESKD account for one-third of the variability of time-to-graft failure. [ABSTRACT FROM AUTHOR]

Published
2023
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98. Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).

Author

Mahamat‐Saleh, Yahya, Al‐Rahmoun, Marie, Severi, Gianluca, Ghiasvand, Reza, Veierod, Marit B., Caini, Saverio, Palli, Domenico, Botteri, Edoardo, Sacerdote, Carlotta, Ricceri, Fulvio, Lukic, Marko, Sánchez, Maria J., Pala, Valeria, Tumino, Rosario, Chiodini, Paolo, Amiano, Pilar, Colorado‐Yohar, Sandra, Chirlaque, María‐Dolores, Ardanaz, Eva, and Bonet, Catalina

Subjects
SKIN cancer, ALCOHOL drinking, BASAL cell carcinoma, DISEASE risk factors, SQUAMOUS cell carcinoma
Abstract

Experimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. The European Prospective Investigation into Cancer and Nutrition (EPIC) is a prospective cohort initiated in 1992 in 10 European countries. Alcohol intake at baseline and average lifetime alcohol intake were assessed using validated country‐specific dietary and lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated in Cox models. A total of 14 037 skin cancer cases (melanoma: n = 2457; basal‐cell carcinoma (BCC): n = 8711; squamous‐cell carcinoma (SCC): n = 1928; unknown: n = 941) were identified among 450 112 participants (average follow‐up: 15 years). Baseline alcohol intake was positively associated with SCC (>15 vs 0.1‐4.9 g/day: HR = 1.44, 95% CI = 1.17‐1.77; Ptrend =.001), BCC (HR = 1.12, 95% CI = 1.01‐1.23; Ptrend =.04), and melanoma risks in men (HR = 1.17, 95% CI = 0.95‐1.44; Ptrend =.17), while associations were more modest in women (SCC: HR = 1.09, 95% CI = 0.90‐1.30; Ptrend =.13; BCC: HR = 1.08, 95% CI = 1.00‐1.17, Ptrend =.03; melanoma: HR = 0.93, 95% CI = 0.80‐1.08, Ptrend =.13). Associations were similar for lifetime alcohol intake, with an attenuated linear trend. Lifetime liquor/spirit intake was positively associated with melanoma (fourth vs first quartile: HR = 1.47, 95% CI = 1.08‐1.99; Ptrend =.0009) and BCC risks in men (HR = 1.17, 95% CI = 1.04‐1.31; Ptrend =.14). Baseline and lifetime intakes of wine were associated with BCC risk (HR = 1.25 in men; HR = 1.11‐1.12; in women). No statistically significant associations were found between beverage types and SCC risk. Intake of beer was not associated with skin cancer risk. Our study suggests positive relationships between alcohol intake and skin cancer risk, which may have important implications for the primary prevention of skin cancer. What's new? Drinking alcohol can make the skin more sensitive to sunlight and vulnerable to skin cancer. Here, the authors conducted a large prospective cohort study to evaluate whether alcohol consumption correlates with skin cancer risk. Among the 450 112 participants, there were 2457 cases of melanoma, 8711 of basal cell carcinoma, and 1928 of squamous cell carcinoma. There was a positive association between alcohol and all three cancer types, stronger in men than in women. The association varied somewhat by beverage type. [ABSTRACT FROM AUTHOR]

Published
2023
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