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Understanding the vertical distribution and driving mechanisms behind soil carbon (C), nitrogen (N), and phosphorus (P) contents and enzyme activities along elevation gradients is of great significance for the healthy and sustainable management of forest ecosystems. For this study, the 0–20 cm soil-layer samples of different natural Quercus spp. secondary forests from eight altitude gradients (ranging from 250 to 950 m) were investigated to quantify their physicochemical properties, ecological stoichiometry characteristics, and enzyme activities. The results indicated that the soil nutrient content of natural secondary Quercus spp. forests in the Dabie Mountains was low, with average soil organic carbon (SOC) and total phosphorus (TP) contents of 19.86 ± 3.56 g·kg−1 and 0.68 ± 0.10 g·kg−1, respectively, which were 19.14% and 12.82% lower, respectively, than the Chinese average. In terms of vertical spatial distribution, the SOC, total nitrogen (TN), and TP contents of the soil at high altitudes (≥750 m) were greater than those at middle- and low-altitude areas and reached the maximum value at or near the top of the mountain (850–950 m). The stoichiometric attributes of the soil ecosystem fluctuated with the higher altitudes in vertical space; however, the fluctuation range was not significant. The C:N, N:P, and C:P ratios reached their maximum values at altitudes of 250, 750, and 850 m, respectively. However, the overall average value remained generally lower than the national average; thus, in forest management, attention should be paid to the supplementation of the soil with C and P. The activities of soil sucrase, urease, acid phosphatase, and catalase were interconnected across the overall space, and increased with altitude. The SOC, TP, and pH were the main factors that influenced the changes in soil enzyme activities.

In this paper, using the continuum-discontinuum element method (CDEM), the fragmentation and outburst process of coal specimen are simulated, and the main factors affecting coal breaking and outburst are explored. The results show that after the coal seam is uncovered, coal generates obvious failure and outburst trend. Near coal-free surface, the fracture coal blocks generate significant displacement, resulting in larger opening widths of coal cracks. Coal deep generates the cracks without an obvious opening width. The crack density of coal with pore gas is larger than those of coal without gas, and it is larger than those of coal without pores. However, in the early stage of coal failure, the obvious separation and outburst ranges of coal with gas are smaller than those of coal without gas, and are smaller than those of coal without pores. The numbers of fracture coal blocks show an increase with the growth of in situ stress, pore ratio and gas pressure. The effect of in situ stress on fracture coal block number (517–10,203) is larger than the effect (7589–15,170) of pore ratio and is larger than the effect (5803–6836) of gas pressure. The effect of in situ stress on a maximum size (0.0387–0.138 m) of fracture blocks is larger than the effect (0.0342–0.0733 m) of pore ratio and is larger than the effect (0.0454–0.0578 m) of gas pressure. The coal outburst velocity and range show an increase with the growth of gas pressure and in situ stress (3.77–5.65 m/s); however, the coal outburst shows a slow decrease with a growth of pore ratio. The effect of gas pressure on the coal outburst velocity (11.51–21.9 m/s) is larger than the effect (3.77–5.65 m/s) of in situ stress and is larger than the effect (4.52–5.23 m/s) of pore ratio. This investigation is beneficial to understand the mechanisms of coal–gas outburst in coal mining and roadway excavation.

Background: We aimed to investigate the clinical effect of low molecular weight heparin (LMWH) combined with magnesium sulfate in patients with severe pre-eclampsia (PE). Methods: A total of 70 patients with severe PE admitted in Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, China from Jun 2020 to May 2021 were enrolled and randomized into observation and control groups. The control group was treated with magnesium sulfate only, and the observation group was treated with small-dose LMWH combined with magnesium sulfate. The clinical effects and artery blood flow index were analyzed. Results: The observation group had higher coagulation function than that in the control group. RI, S/D, and PI in the observation group after treatment were lower than those in the control group, with statistically significant differences (P

PurposeThis study aims to accomplish two tasks for International Classification of Functioning, Disability and Health (ICF) application among persons with stroke: (1) to make an ICF tool for measuring personal abilities with simplified assessment operations; (2) to quantitatively evaluate ICF categories for being functioning rather than being disabled.MethodsA total of 130 inpatients with stroke via convenience sampling were evaluated by the extended comprehensive ICF core set for stroke, modified Rankin scale, and modified Barthel index (MBI). This study investigated the responses to 118 stroke-related ICF items (59 items in b and d domains individually) using Mokken scale analysis followed with Rasch modeling.ResultsA Mokken scale with 47 items was extracted from the binary data (1 as no-impairment or mild-impairment and 0 as moderate to complete impairment). A Rasch model with 45 items was derived from the Mokken scale. The conversion chart was available involving the original ordinal scores to Rasch-transformed scores from 0 to 100 (interval scale). Total scores exhibited a high correlation with the personal abilities estimated by the Rasch model. The personal ability also demonstrated a significantly strong correlation with the score of the MBI. Thus, the 45 ICF items were suggested to rate potential functional ability as a single measurement.ConclusionBased on simple “functioning or disabled” judgment tasks, ICF assessment can be simplified to a questionnaire with answering “yes-or-no” questions for each category. Functioning level for each person and difficulty of being functioning for each category can be estimated by the Rasch model of this questionnaire.

Abstract Background and aims It has been reported that Helicobacter pylori (HP) infection was more prevalent in infertile populations. HP infection could lead to decreased sperm parameters, and treating the HP infection could improve the quality of sperm. However, studies investigating the relationship between infertility and HP infection are still limited, and more evidence is required. Therefore, we performed the present study to investigate the impact of HP infection on sperm quality in males and on ovarian reserve in females. Methods A total of 16,522 patients who visited the Second Hospital of Zhejiang University from January 2016 to June 2019 due to abdominal discomfort and underwent a 13/14C-urea breath HP test were included in this retrospective cross-sectional study. Among them, 565 had performed sperm analysis or ovarian reserve tests in the past three months and were involved for further analyses. Sperm parameters were examined with a computer-assisted sperm analysis system, and serum anti-Müllerian hormone (AMH) and sex hormones were tested with an electrochemiluminescence method. Results Among 363 patients who underwent the sperm test, 136 (37.47%) had HP infection. Among 202 patients who underwent the AMH test, 55 (27.23%) had HP infection. There was no difference in sperm concentration and motility between the HP+ and HP− groups (P > 0.05). Further subgroup analyses stratified into 5-year age groups confirmed that there was no significant difference in sperm parameters (P > 0.05). When pooled with previously published data, no significant difference in sperm concentration or motility was found (P > 0.05). Meanwhile, this study found that the serum AMH level was similar between the HP+ and HP− groups (P > 0.05). Further subgroup analyses confirmed that there was no significant difference in serum AMH level (P > 0.05). Conclusions There were no differences in sperm parameters and AMH levels based on history of HP infection among Chinese patients.

Abstract Background Baicalin, the main metabolic component of Scutellaria baicalensis Georgi, has various pharmacological properties including anti-inflammatory, anti-oxidant, anti-apoptotic, anti-bactericidal and anti-viral. The purpose of this study was to investigate the anti-Marek’s disease virus (MDV) activities of baicalin in CEF cells. Results Here, we showed that baicalin could inhibit viral mRNA, protein levels and overall plaque formation in a time-dependent manner. We also found that baicalin could consistently inhibit MDV replication and directly affect the virus infectivity. Moreover, baicalin treatment has no effect on expression level of antiviral cytokine and inflammatory cytokines in MDV infected CEFs. Conclusions These results demonstrate that baicalin could be a potential drug against MDV infection.

Spin-polarized current manipulation of magnetic skyrmions is energy consuming. Here, the authors achieve an electric-field manipulation of individual skyrmions in a nanostructured ferromagnetic/ferroelectrical heterostructure at room temperature via an inverse magneto-mechanical effect.

Abstract Background Anti-Müllerian hormone (AMH) is now considered the best serum biomarker of ovarian reserve, while basal sex hormones are classic markers used for assessing ovarian reserve. The interaction between AMH and sex hormones are complicated and not sufficiently addressed. In this study, we took diminished ovarian reserve (DOR) and polycystic ovarian syndrome (PCOS) as two extremes of ovarian reserve (deficient and excessive respectively) to investigate the role of AMH and sex hormones in follicular growth. Methods A retrospective cross-sectional survey was performed. The patients assessed AMH and basal sex hormones in the Second Hospital of Zhejiang University from April 2016 to March 2019 were involved in this study. Serum AMH and sex hormone concentrations were tested with electrochemiluminescence method. Stepwise linear regression and binary logistic regression was used to determine the predictors of AMH level and to explore the involved factors determining DOR and PCOS. Results In the present study, we found that age and follicle-stimulating hormone (FSH) were main negative correlation factors, and luteinizing hormone (LH) and testosterone (T) were main positive factors of AMH. In DOR group, age, FSH and estradiol (E2) increased and T decreased, while in PCOS group, LH and T increased. Binary logistic regression found that age, weight, FSH, E2, and T were the significant factors which independently predicted the likelihood of DOR, and that age, body mass index (BMI), AMH, LH, and T predicted the likelihood of PCOS. Conclusions Our study demonstrated that age, FSH, and T were factors that most closely correlated with AMH level, and T was involved in both DOR and PCOS. Since DOR and PCOS are manifested with insufficient AMH and excessive AMH respectively, it is suggested that total testosterone correlated with AMH closely and plays an important role in follicular growth. More attention should be given to testosterone level during controlled ovarian hyperstimulation (COH) process.

ABSTRACT: To simulate the progressive failure of slope, a block particle coupled model is introduced. Particle oriented cell mapping (POCM) algorithm is used to enhance the search efficiency, and particle-point, particle-edge, particle-face contact detecting method is adopted to establish contact pair between particles and blocks precisely. Strain softening Mohr Coulomb model with tensile cutoff is adopted for blocks, and brittle Mohr Coulomb model is used for particles. The particle-block replacement approach is used to describe the fracture and fragmentation process of continuum media. Once the cohesion or tensile strength of one block reaches zero, the block will be deleted, and particles are generated at the same place with all information inherited from the deleted block. Some numerical cases related to landslides demonstrate the precision and rationality of the coupled model. Keywords: Finite element method, Discrete element method, Fracture, Fragmentation, Landslide

In situ fluidization mining is a promising method which shows considerable potential for reducing the ecological influence impacts of coal mining. During fluidization mining, coal gangue will be separated from the ores, filled back, and returned to the excavation region, which, depending on the filling rate, greatly reduces the stratum deformation of strata, depending on the filling rate. Numerical simulations can assist engineers in evaluating stratum deformation and optimizing affordable designs with affordable costs. Accordingly, in this work, a continuous–discontinuous element method is adopted, which is a coupled particle–block finite-discrete element method with an explicit integration formulation, which is adopted for simulating the coal in situ fluidization mining–filling processes. The theory concept of an “equivalent mining height” is utilized to define the backfill mining height. The results partly reveal the influences of the filling rate on the stratum deformation, surface subsidence, and rock burst phenomena, all of which further indicate the advantages of the fluidization mining method.

Many factors need to be considered in the evaluation of tight conglomerate reservoirs, including the microscopic pore-throat structure, pore connectivity, lithology, porosity, permeability, and clay mineral content. The contents and types of clay minerals reflect the mineral evolution process during the deposition of the reservoir and can reflect the reservoir’s physical properties to a certain extent. In this study, cores from the Baikouquan Formation in Mahu were used to comprehensively analyze the effects of the clay mineral content on the physical properties of a tight conglomerate reservoir, including field emission scanning electron microscopy (FE-SEM), casting thin section observations, X-ray diffraction (XRD), interface property testing, high-pressure mercury injection, low temperature N2 adsorption, and nuclear magnetic resonance (NMR)-movable fluid saturation testing. The results revealed that differences in different lithologies lead to differences in clay mineral content and pore structure, which in turn lead to differences in porosity and permeability. The interface electrification, adsorption, and specific surface area of the reservoir are positively correlated with the clay mineral content, which is mainly affected by the smectite content. As the clay mineral content increases, the proportion of nanoscale pore throats increases, and the core becomes denser. The saturation of the movable fluid controlled by the >50 nm pore throats in the tight conglomerate ranges from 8.7% to 33.72%, with an average of 20.24%. The clay mineral content, especially the I/S (mixed layer of Illite and montmorillonite) content, is negatively correlated with the movable fluid. In general, the research results clarified the relationship between the lithology and physical properties of clay minerals and the microscopic pore structure of the tight conglomerate reservoirs in the Baikouquan Formation in the Mahu area.

Previous studies have shown that males with substance use disorder (SUD) in their first mandatory detoxification experience high rates of depression. It is unknown whether this high depression incidence contributes to impaired inhibition. In this work, two studies were undertaken to examine the role of depression in cognitive inhibition in heroin and methamphetamine withdrawal. We used the Beck Depression Inventory (BDI) and the self-control scale (SCS) to explore the relationship between depression and impulse inhibition in patients participating in mandatory drug treatment for the first time (Study 1). The results showed that depression negatively predicted impulse inhibition. The Stroop color–word interference task was used to explore the role of patients’ depression in their inhibitory abilities (Study 2). The results showed that the high-depression group had weaker inhibition performances in the Stroop color–word interference task compared to the low-depression group. This study shows that cognitive inhibition is weaker in people with high-depression addiction than in those with low depression. This result suggests that attention should be paid to the role of depressive comorbidity when conducting working memory training treatment for substance addiction.

For brittle and quasi-brittle materials such as rock and concrete, the impact-resistance characteristics of the corresponding engineering structures are key to successful application under complex service environments. Modeling of concrete-like slab fractures under impact loading is helpful to analyze the failure mechanism of an engineering structure. In this paper, simulation models of impact tests of a cement mortar slab were developed, and a continuum–discontinuum element method (CDEM) was used for dynamic analysis. Concretely, the cracking simulations of a mortar slab when considering the hammer shape and impact velocity were conducted, and the impact process and failure results of the slab structure were analyzed. The results showed that the top fracture area of the mortar slab was significantly smaller than that of slab bottom under impact loadings of the drop hammer. The impact velocity was an important factor that affected the mortar slab’s cracking. With the increase in the initial impact velocity, the effective fracture area of the slab structure increased significantly; the impact force and rupture degree of the mortar slab also showed a linear growth trend. The shapes of the impact hammerhead also had a significant effect on the crack model of the mortar slab. The effective fracture zones of slab structures were close under circular and square hammers, while the effective fracture zone was significantly larger under a rectangular hammer impact. The peak value (45.5 KN) of the impact force under a circular hammer was significantly smaller than the peak value (48.7 KN) of the impact force under the rectangular hammer. When considering the influence of the stress concentration of the impact hammerhead, the maximum impact stress of the rectangular hammer was 147.3 MPa, which was significantly greater than that of the circular hammer impact (maximum stress of 87.5 MPa). This may have meant that the slab structures were prone to a directional rupture that mainly propagated along the long axis of the rectangular hammerhead. This impact mode is therefore more suitable for rehabilitation and reconstruction projects of slab structures.

Soil resident bacterial communities are involved in myriad key processes that facilitate ecosystem functionality. However, our understanding of their diversity and compositional dynamics following ecological restoration, and the main factors that influence them, remains inadequate. We employed a chronosequence (0–1, 5–6, 11–12, 20–24, and 28–34 years since restoration) to examine the dynamic changes in soil bacterial diversity and composition, as well as the essential factors that affected them since the cessation of anthropogenic disturbances (e.g., recurring fuelwood collection and domestic animal grazing), and used old-growth forests as a reference in the subtropical forests of Eastern China. We found that soil bacterial diversity increased with time since restoration, and community compositions shifted toward being similar to those of old-growth forests over time. However, the recovery process was prolonged since the significant difference in soil bacterial diversity between degraded and restored forests did not occur until after 24 years since restoration. Multivariate analysis using multiple-response permutation procedures indicated the soil bacterial communities were compositionally distinct between degraded, restored, and old-growth forests. An analysis of indicator species revealed that forests at the early stage of recovery times supported Rokubacteria and Actinobacteria, while old-growth forests were distinguished by Chlamydiae. Soil carbon, microbial biomass carbon, soil water content, and microbial biomass nitrogen recovered over time and became increasingly akin to those of old-growth forest soils. Soil carbon, soil water content, and soil pH could explain 84.5% of the variations in bacterial community dynamics following restoration. Overall, this study revealed a prolonged recovery process of the community structures of soil bacteria (e.g., diversity, composition, and phylum abundance) following restoration, which was coupled with changes in soil properties in subtropical forests of China.

During blasting, rock failure is caused by blasting wave and explosive gas pressure, as a multi-field coupled process. Most numerical models focus on the effect of blasting wave where the gas pressure is commonly accounted for by empirical relations, ignoring the penetration and permeation of gas flow in cracks. This can underestimate the failure region. In this work, a novel multi-field model is developed in the framework of a continuous-discontinuous element method (CDEM), which is a coupled finite-discrete method with explicit integration strategy. The deformation and cracking of rock mass and the distribution of gas pressure are captured. The proposed method is verified by comparing the results to other results provided in published literature. Especially, by simulating the cases with blocked and unblocked blasting hole, we found that: (i) The fracture degree of the case with blocked blasting hole was 30% higher than that of the unblocked blasting hole. (ii) The radial main cracks in the fracture area are mainly caused by the explosive gas, and the tiny and dense cracks near the hole are induced by the explosion stress wave. (iii) The explosion crushing zone is mainly formed by the action of explosion stress wave, while the crack zone is formed by the combined action of the explosion stress wave and explosive gas. The proposed method provides a useful tool to properly simulate a rock blasting process.

It is unclear whether the state of boredom is related to morality. The present study investigated how state boredom influenced cheating behaviors on task performance. In Study 1 (N = 104), participants were induced to feel bored, and then reported whether they had finished an anagram task (two sentences in the task were unsolvable). The results found that people with higher boredom showed more cheating behaviors than those with lower boredom on task performance. In Study 2 (N = 139), participants completed the Multidimensional State Boredom Scale, and then completed the same anagram task as in Study 1, as well as a state self-efficacy scale. The results revealed that state self-efficacy mediated the effect of state boredom on cheating behaviors on task performance. In other words, a higher level of state boredom leads to a lower level of state self-efficacy, and the lower state self-efficacy then results in more cheating behaviors. The present study provides empirical evidence that state boredom has its moral function through state self-efficacy.

High molecular polymers have been widely studied and applied in the field of enhanced oil recovery (EOR). At present, the focus of research has been changed to the design of polymer networks with unique properties such as anti-temperature and anti-salinity, good injection and so on. Supramolecular polymers have high viscoelasticity as well as excellent temperature, salt resistance and injection properties. Can supramolecular polymers become another material choice for polymer flooding to enhance oil recovery? The present review aims to systematically introduce supramolecular polymers, including its design strategy, interactions and rheological properties, and address three main concerns: (1) Why choose supramolecular polymers? (2) How do we synthesize and characterize supramolecular polymers in the field of oilfield chemistry? (3) What has been the application progress of supramolecular polymers in improving oil recovery? The introduction of a supramolecular interaction system provides a new idea for polymer flooding and opens up a new research direction to improve oil recovery. Aiming at the “reversible dynamic” supramolecular polymers, the supramolecular polymers are compared with the conventional covalent macromolecular polymer networks, and the challenges and future research directions of supramolecular polymers in EOR are discussed. Finally, the author’s viewpoints and perspectives in this emerging field are discussed.

The CNI model generates C, N, and I parameters to measure people’s mental processes—consequence sensitivity (C), norm sensitivity (N), and generalized inaction/action preferences (I)—in moral decision making. Given the limitations of the CNI model, the CAN algorithm was developed to depict the consequence sensitivity (C), overall action versus inaction preferences (A), norm sensitivity (N), and perverse responses with the other three parameters. However, no studies have clarified whether and how the CAN algorithm can solve the limitations of the CNI model. The present study systematically uncovers the limitations of the CNI model and the solutions provided by the CAN algorithm: (a) the CNI model does not consider negative values of the parameters, but the CAN algorithm does; (b) the sequential processing assumption of the CNI model is biased, the CAN algorithm proposes a parallel calculation strategy to fix this problem; (c) the calculation of the I parameter of the CNI model is inaccurate, so the CAN algorithm proposes the A parameter to replace it; (d) the CNI model has a problem measuring perverse responses, while the CAN algorithm develops three parameters to measure these. We examined some of our points on the basis of a reanalysis of the foreign language effect (FLE) by comparing the parameters from the CAN algorithm with those from the CNI model. We found that consequence and norm sensitivity were estimated to be greater using the CNI model than with the CAN algorithm. Consequently, these overestimations significantly (consequence sensitivity) and marginally (norm sensitivity) interfered with the FLE, making the FLE more likely to return a false positive result. In addition, the CAN algorithm was able to measure the extent of perverse responses, indicating that foreign language (compared to a native language) leads to more perverse responses. The present study demonstrates that the CNI model magnifies the Type I error of conclusions and that the CAN algorithm (compared to the CNI model) provides more insights regarding moral decision making.

Ultraviolet-visible absorption spectroscopy is widely used to monitor water quality, and rapid optical signal detection is a key technology in the process of spectrum measurement. In this paper, an ultrafast spectrophotometer system that can achieve spectrum data acquisition in a single flash of the xenon lamp (within 200 ns) is introduced, and a real-time denoising method for the spectrum is implemented on a field programmable gate array (FPGA) to work cooperatively with the nanosecond spectrum acquisition system, in order to guarantee the quality of the spectrum signals without losing running speed. The hardware of the data acquisition and processing system are constructed on a Xilinx Spartan 6 FPGA chip and its peripheral circuit, including an analog to digital converter and a complementary metal-oxide-semiconductor transistor (CMOS) sensor’s diver circuit. An oversampling method that is suitable for the CMOS sensor’s output is proposed, which works on the CMOS sensor’s dark current noise and readout noise. Another moving-average filter method is designed adaptively, which works on the low-frequency component to filter out the residual spectrum noise of the spectrum signal. The implementation of the filter on the FPGA has been optimized by using a pipelined structure and dual high-speed random-access memory (RAM). As a result, the CMOS linear image sensor successfully captured the spectrum of xenon flash light at the readout clock frequency of 500 kHz and the processing manipulation to the full UV-Vis spectrum data was accomplished at a sub-microsecond speed performance. After the digital filter and oversampling technology were implemented, the coefficient of variation of the measurements reduced from 9.57% to 1.74%, while the signal noise ratio (SNR) of the absorption spectrum increased nine times, compared to the raw data of the CMOS sensor’s output. The tests towards different analyte samples were conducted, and the system shows good performance on distinguishing different concentrations of different analyte solutions on both ultra-violet and visible spectrum bands. The present work showcases the potential of the CMOS sensor’s technique for the fast detection of contaminated water containing nitrate and organic compounds.

Bone homeostasis is maintained with the balance between bone formation and bone resorption, which is involved in the functional performance of osteoblast and osteoclast. Disruption of this equilibrium usually causes bone disorders including osteoporosis, osteoarthritis, and osteosclerosis. In addition, aberrant activity of bone also contributes to the bone metastasis that frequently occurs in the late stage of aggressive cancers. Orphan nuclear receptor estrogen-related receptor (ERRα) has been demonstrated to control the bone cell fate and the progression of tumor cells in bone through crosstalk with various molecules and signaling pathways. However, the defined function of this receptor in bone is inconsistent and controversial. Therefore, we summarized the latest research and conducted an overview to reveal the regulatory effect of ERRα on bone homeostasis and bone metastasis, this review may broaden the present understanding of the cellular and molecular model of ERRα and highlight its potential implication in clinical therapy.

In this study, the continuum-discontinuum element method (CDEM) was used to investigate the tensile fracture mechanism of rock materials. An isotropic rock disk model and models considering different foliation inclinations were established, and three schemes were used to simulate the rock fracturing in Brazilian test. Then, the influences of the rock matrix and foliation strengths on anisotropy rock fracturing were investigated. Furtherly, simulation results were verified, and the rock fracture mechanisms were discussed. The results show that the rock fracturing in Brazilian test can be accurately simulated by CDEM, which is in accordance with the experimental results. For isotropic and horizontal foliation rock, the stress concentration in loading positions causes a local fracture of rock sample, and application of a local strengthening scheme can simulate the integral tension fracture of sample middle. As the foliation angle varies from 15° to 45°, the rock fracturing is affected by the stress concentration and foliation distribution. In splitting simulation, a strengthening scheme should be adopted to overcome this influence. As a result, the rock sample generates the sliding and compression-shear fracture. As the foliation angle changes from 45° to 75°, the foliation, rather than the matrix, dominates the fracture behavior of rock sample. For vertical foliations’ rock, as the middle foliation thickness is appropriately broadened, the simulation results are reasonable. In general, the tensile strength of anisotropic rock entirely decreases with an increase of foliation angle, and the effect of foliation strength on the tensile strength rock sample is larger than that of the rock matrix.

High-cycle fatigue (HCF) behaviors of medium-carbon bainitic steels with various inclusion sizes and microstructural features were studied using the rotating–bending fatigue test. Here, the medium-carbon bainitic steels with different melting processes were treated by three heat treatment routes incorporating bainite formation, namely bainite-based quenching plus partitioning (BQ&P), bainite austempering (BAT) and “disturbed bainite austempering, DBAT”. The interior inclusion-induced crack initiation (IICI) and noninclusion-induced crack initiation (NIICI) modes were found after fatigue failure. The fracture surface of IICI is characterized by a “fish-eye” surrounding a “fine granular area, FGA” in the vicinity of an inclusion. In contrast, a microfacet, instead of an inclusion, is found at the center of FGA for the NIICI fracture surface. The predications of fatigue strength and life were performed on the two crack initiation modes based on fracture surface analysis. The results showed that a majority of fatigue life is consumed within the FGA for both the IICI and NIICI failure modes. The fatigue strength of the NIICI-fatigued samples can be conveniently predicted via the two parameters of the hardness of the sample and the size of the microfacet.

Tailoring the soft magnetic properties of CoZrTa thin film is a critical issue for enhancing magnetic recording stability for practical applications. In this work, the effect of introducing B atoms on the magnetic properties and microstructure of the CoZrTa(B) thin film was studied. The results show that the in-plane coercivity of the CoZrTaB thin film is smaller than that of the CoZrTa thin film. High-resolution transmission electron microscopy results show that the CoZrTa thin film is partially crystallized, while the CoZrTaB thin film is amorphous with a long-range disorder characteristic, indicating that the B atoms hinder crystallization and play a positive role in promoting the formation of an amorphous structure. X-ray electron spectroscopy analysis reveals that there exists a Co2B alloy in the CoZrTaB thin film, which increases the Gibbs free energy of the system and increases the energy barrier for crystallization of the film, inducing the formation of an amorphous structure. This is an important reason for obtaining good soft magnetic properties in the CoZrTaB thin film. These findings provide useful guidance for tuning the properties of the soft magnetic underlayers and also clarify the effect of amorphous structure on Co-based soft magnetic materials.

Abstract Background Percutaneous kyphoplasty (PKP) is the first-line treatment for osteoporotic vertebral compression fractures (OVCFs) that can immediately relieve pain and allow the quick recovery of lost mobility. However, some studies reported that after PKP, the incidence of vertebral refracture, particularly adjacent vertebral fracture (AVF), was high. Our previous meta-analysis suggested that the risks for vertebral refracture and AVF did not increase after percutaneous vertebral augmentation in OVCF patients. Despite the negative results of our meta-analysis, there is still significant evidence regarding the relationship between kyphoplasty and AVF, so a new prospective cohort study is warranted. In addition, in our previous retrospective study, we found that advanced age, female sex and low oestradiol (E2) concentrations might be related to the occurrence of postoperative vertebral refracture after PKP. To sufficiently evaluate the probable factors involved in the occurrence of postoperative vertebral refracture, we designed this prospective study. Methods This is a prospective cohort study of patients admitted for PKP to treat painful OVCFs. The baseline data, including demographic information, lifestyle, bone metabolic status, sex hormone and sex hormone-binding globulin (SHBG) levels, and clinical characteristics will be collected at the time of enrolment. Surgical features of PKP will be recorded on the operation day. Lifestyle, bone metabolic status, sex hormone levels, and SHBG levels will be assessed during the follow-up period at 1 m, 3 m, 12 m, and 24 m postoperatively. Patients suffering from acutely aggravated back pain will be referred to an orthopaedist, and refractured vertebrae will be confirmed by magnetic resonance imaging and computed tomography. The primary outcome will be the incidence of vertebral refracture. Multivariate analyses will be carried out to evaluate the variables that are independently correlated with vertebral refracture. Discussion To evaluate the risk of postoperative refracture preoperatively and to identify the surgical points related to postoperative refracture, this study will explore the risk factors related to vertebral refracture after PKP. The results may provide new information about defining OVCF patients suitable for PKP treatment. Trial registration ChiCTR-ROC-17011562. Registered on July 4th, 2017.

To achieve rapid and sensitive detection of the toxicity of pollutants in the aquatic environment, a photosynthetic inhibition method with microalgae as the test organism and photosynthetic fluorescence parameters as the test endpoint was proposed. In this study, eight environmental pollutants were selected to act on the tested organism, Chlorella pyrenoidosa, including herbicides (diuron, atrazine), fungicides (fuberidazole), organic chemical raw materials (phenanthrene, phenol, p-benzoquinone), disinfectants (trichloroacetonitrile uric acid), and disinfection by-products (trichloroacetonitrile). The results showed that, in addition to specific PSII inhibitors (diuretic and atrazine), other types of pollutants could also quickly affect the photosynthetic system. The photosynthetic fluorescence parameters (Fv/Fm, Yield, α, and rP) could be used to detect the effects of pollutants on the photosynthetic system. Although the decay rate of the photosynthetic fluorescence parameters corresponding to the different pollutants was different, 1 h could be used as an appropriate toxicity exposure time. Moreover, the lowest respondent concentrations of photosynthetic fluorescence parameters to diuron, atrazine, fuberidazole, phenanthrene, P-benzoquinone, phenol, trichloroacetonitrile uric acid, and trichloroacetonitrile were 2 μg·L−1, 5 μg·L−1, 0.05 mg·L−1, 2 μg·L−1, 1.0 mg·L−1, 0.4 g·L−1, 0.1 mg·L−1, and 2.0 mg·L−1, respectively. Finally, diuron, atrazine, fuberidazole, and phenanthrene were selected for a comparison of their photosynthetic inhibition and growth inhibition. The results suggested that photosynthetic inhibition could overcome the time dependence of growth inhibition and shorten the toxic exposure time from more than 24 h to less than 1 h, or even a few minutes, while, the sensitivity of the toxicity test was not weakened. This study indicates that the photosynthetic inhibition method could be used for rapid detection of the toxicity of water pollutants and that algae fluorescence provides convenient access to toxicity data.

CrN, AlN, TiN layer were prepared as diffusion barriers between the K417 substrate and Ni+CrAlYSiN nano composite coatings via vacuum arc evaporation. Oxidation kinetics and microstructure evaluation of these nano coating systems at 1000 °C after 100 h were studied. Results show that the AlN layer showed good thermodynamic stability, effectively inhibited the interdiffusion between the coating and the substrate, improved the oxidation resistance of Ni+CrAlYSiN nano composite coatings, and a single-layer Al2O3 film was formed on the coating. The CrN layer was decomposed, which did not block the diffusion of elements and had little effect on the oxidation resistance of the Ni+CrAlYSiN nano composite coating. The TiN layer effectively prevented the interdiffusion between the coating and the substrate. However, it deteriorated the oxidation resistance of the composite coating. Similar to the Ni+CrAlYSiN coating without a diffusion barrier, a double-layer oxide film structure with Al2O3 as the inner layer and Ni(Al,Cr)2O4 as the outer layer formed on the Ni+CrAlYSiN nano composite coatings with the CrN or TiN diffusion barrier.

Producing well-defined polymer compositions and structures facilitates their use in many different applications. Here the authors show the synthesis of well-defined asymmetric double-brushes by a one-pot concurrent atom transfer radical polymerization and Cu-catalyzed Click reaction.

Background: Excessive androgen exposure during pregnancy has been suggested to induce diabetic phenotypes in offspring in animal models. The aim of this study was to investigate whether pregestational maternal hyperandrogenism in human influenced the glucose metabolism in offspring via epigenetic memory from mother's oocyte to child's somatic cells. Methods: Of 1782 reproductive-aged women detected pregestational serum androgen, 1406 were pregnant between 2005 and 2010. Of 1198 women who delivered, 1116 eligible mothers (147 with hyperandrogenism and 969 normal) were recruited. 1216 children (156 children born to mothers with hyperandrogenism and 1060 born to normal mother) were followed up their glycometabolism in mean age of 5 years. Imprinting genes of oocyte from mothers and lymphocytes from children were examined. A pregestational hyperandrogenism rat model was also established. Findings: Children born to women with hyperandrogenism showed increased serum fasting glucose and insulin levels, and were more prone to prediabetes (adjusted RR: 3.98 (95%CI 1.16–13.58)). Oocytes from women with hyperandrogenism showed increased insulin-like growth factor 2 (IGF2) expression. Lymphocytes from their children also showed increased IGF2 expression and decreased IGF2 methylation. Treatment of human oocytes with dihydrotestosterone upregulated IGF2 and downregulated DNMT3a levels. In rat, pregestational hyperandrogenism induced diabetic phenotypes and impaired insulin secretion in offspring. In consistent with the findings in human, hyperandrogenism also increased Igf2 expression and decreased DNMT3a in rat oocytes. Importantly, the same altered methylation signatures of Igf2 were identified in the offspring pancreatic islets. Interpretation: Pregestational hyperandrogenism may predispose offspring to glucose metabolism disorder via epigenetic oocyte inheritance. Clinical trial registry no.: ChiCTR-OCC-14004537; www.chictr.org.

Ampelopsis grossedentata (Hand.-Mazz.) W. T. Wang is rich in flavonoids and also displays excellent pharmacological activities. The phylogenetic relationship between A. grossedentata and other related Vitaceae family members remains unclear. The chloroplast (cp) genome is a useful model for assessing genome evolution. In this study, we assembled the cp genome of A. grossedentata using the high-throughput Illumina pair-end sequencing data and characterized the genome to providing useful information for future genetic studies. The circular cp genome was 162,147 bp in size, including a large single-copy (LSC) region of 89,244 bp and a small single-copy (SSC) region of 18,439 bp, which were separated by two inverted repeat (IR) regions (27,232 bp each). A total of 135 genes were predicted, including 8 ribosomal RNAs (rRNAs), 37 transfer RNAs (tRNAs), and 90 protein-coding genes (PCGs). Furthermore, phylogenetic analysis revealed that A. grossedentata within Ampelopsis genus and formed a different clade from other three congeneric species. This study provides useful information for future genetic study of A. grossedentata.

This research use SC-IAT, cognition to Mexico or China test and cultural contact experiment to study the implicit attitude of Mexican and Chinese college students to mutual culture. The results show that (a) Chinese college students have positive implicit attitude to Mexican culture in pretest and posttest of SC-IAT; (b) In the SC-IAT post-test, Chinese college students in experimental group hold more positive attitude than those in Chinese control group (t= 2.554, p0.01); (e) Mexican college students in experimental group hold more positive attitude than those in Mexican control group in post-test of SC-IAT (t= -4.22, p

The homogenized micro-crack crushing technology for concrete pavement maintenance has received increased attention in China. To study the fracture mechanism of the homogenized micro-crack crushing technology, a low-velocity impact test system is developed and experiments using concrete slabs of different thicknesses are conducted with different drop heights and hammer weights. Furthermore, the fracture of concrete slabs under impact loading is simulated using the continuous-discontinuous element method. Finally, the fracture mechanism is investigated in a case study. It is concluded that a cylindrical compression–shear fracture surface appears under the impact head while the fractured blocks are still interlocked with each other. The main cracks in the concrete slabs are initiated and propagate parallel to the longer side of the impact head, whereas branch cracks develop perpendicular to the main cracks. These cracks radiate from the center of the impact head. The cracks inside the concrete develop upward from the bottom of the slabs. Because fractured blocks divided by micro-cracks can interlock with themselves and the crack distributions tend to be uniform, it is beneficial for portland cement concrete pavement rehabilitation to be overlaid by a hot-mix asphalt mixture.

An amendment to this paper has been published and can be accessed via the original article.

The influence of the repair process on the electrical properties of the normally off p-GaN high-electron-mobility transistor (HEMT) is studied in detail in this paper. We find that the etching process will cause the two-dimensional electron gas (2DEG) and the mobility of the p-GaN HEMT to decrease. However, the repair process will gradually recover the electrical properties. We study different repair methods and different repair conditions, propose the best repair conditions, and further fabricate the p-GaN HEMTs devices. The threshold voltage of the fabricated device is 1.6 V, the maximum gate voltage is 7 V, and the on-resistance is 23 Ω·mm. The device has a good performance, which proves that the repair conditions can be successfully applied to the fabricate of the p-GaN HEMT devices.

New ore pulverizing technology was proposed by the Institute of mechanics, Chinese Academy of Sciences. In order to study the applicability of the new ore pulverizing technology to different materials, several experiments were carried out. In this paper, the author used the new ore pulverizing technology to pulverize iron ore, kaolin, wood and PVC, and finds that the new ore pulverizing technology has good application for iron ore, kaolin wood but for PVC. The experimental results show the application scope of the new ore pulverizing technology.

MicroRNA-29a (miR-29a) has been extensively studied in tumor biology and fibrotic diseases, but little is known about its functional roles in vascular smooth muscle cell (VSMC) differentiation from embryonic stem cells (ESCs). Using well-established VSMC differentiation models, we have observed that miR-29a induces VSMC differentiation from mouse ESCs by negatively regulating YY1, a transcription factor that inhibits muscle cell differentiation and muscle-specific gene expression. Moreover, gene expression levels of three VSMC specific transcriptional factors were up-regulated by miR-29a over-expression, but down-regulated by miR-29a inhibition or YY1 over-expression. Taken together, our data demonstrate that miR-29a and its target gene, YY1, play a regulatory role in VSMC differentiation from ESCs in vitro and in vivo.

The regioselective mono-bromination of phenols has been successfully developed with KBr and ZnAl−BrO3−−layered double hydroxides (abbreviated as ZnAl−BrO3−−LDHs) as brominating reagents. The para site is much favorable and the ortho site takes the priority if para site is occupied. This reaction featured with excellent regioselectivity, cheap brominating reagents, mild reaction condition, high atom economy, broad substrate scope, and provided an efficient method to synthesize bromophenols.

The temperature uniformity and heating efficiency in a high-temperature epitaxial growth system were investigated by modeling and simulating. The finite element method (FEM) was used to calculate the distribution of magnetic field and temperature field in the reactor of growth system. The simulation results showed that due to the skin effect and heat conduction in the conventional susceptor, the temperature distribution of the wafer on the susceptor is not uniform. However, the temperature uniformity of the wafer can be greatly improved by adding an air gap below the wafer. The existence of air gap effectively reduced the temperature on the center of the wafer, and the effect of its radius on temperature uniformity was studied. By calculating different frequencies and coil currents, the temperature and heating rate in the reactor with modified susceptor were investigated. The results indicated that higher temperature and faster heating rate can be obtained by increasing heating frequency and coil current. However, both lower and higher frequency will bring worse temperature uniformity.

In this study, based on the mining of the 13210 working face in the Yima coal mine of the Gengcun village, China, a simplified mechanical model for the analysis of dynamic destabilization of the overlying strata during underground mining was constructed. The numerical simulation was used to analyze the stress patterns in the advanced abutments of the tunnel face and the characteristics of dynamic failures in the overlying strata. Furthermore, similitude experiments were conducted to study the process of stress release and deformation in the overlying strata, and to analyze the effects of overburden destabilization on the ground surface settlement. The theoretical analysis indicated that if the geometric parameters of a working face are fully determined, a stiffness ratio no greater than 1 is required for dynamic destabilization to occur. The numerical simulation results show that the stress in the overlying strata decreases with a decrease in distance from the tunnel face. The stresses in the advanced abutments initially increase with an increase in distance from the tunnel face, followed by a decrease in stress, and an eventual stabilization of the stress levels; this corresponds to the existence of a “stress build-up zone,” “stress reduction zone,” and “native rock stress zone.” In similitude experiments, it was observed that a “pseudoplastic beam” state arises after the local stresses of the overlying strata have been completely released, and the “trapezoidal” fractures begin to form at stress concentrations. If the excavation of the working face continues to progress, the area of collapse expands upward, thereby increasing the areas of the fracture and densification zones. Owing to the nonuniform settlement of the overlying strata and the continuous development of bed-separating cracks, secondary fractures will be generated on both sides of the working face, which increase the severity of the ground surface settlement.

Polycystic ovary syndrome (PCOS) is the most common gynecological endocrine disorder. The genetic background is believed to play a crucial role in the pathogenesis of PCOS. In recent years, the role of insulin receptor (INSR) polymorphisms in PCOS predisposition has attracted much attention. We performed a meta-analysis to investigate the association between the single nucleotide polymorphisms (SNPs) of INSR and PCOS. Published literature from Pubmed, Embase, and Cochrane CENTRAL was retrieved up until 7 August 2014. A total of 20 case-control studies including 23,845 controls and 17,460 PCOS cases with an average Newcastle-Ottawa quality assessment scale (NOS) score of 6.75 were analyzed. Ninety-eight SNPs distributed in 23 exons and the flanking regions of INSR were investigated, among which 17 SNPs were found to be associated with PCOS. Three SNPs detected in more than three studies were selected for further analyses. Twelve studies including 1158 controls and 1264 PCOS cases entered the analysis of rs1799817, but no significant association was found for every genotype (p > 0.05). Further subgroup stratification by ethnicity and weight did not lead to discovery of significant correlation (p > 0.05). For rs2059806, four studies including 442 controls and 524 PCOS cases were qualified for meta-analysis, and no significant association with PCOS was found for any genotype (p > 0.05). Four studies including 12,830 controls and 11,683 PCOS cases investigated the correlation between rs2059807 and PCOS, and five of the six cohorts indicated a significant impact. Our current meta-analysis suggests no significant correlation between rs1799817/rs2059806 SNPs and susceptibility of PCOS, while rs2059807 could be a promising candidate SNP that might be involved in the susceptibility of PCOS.