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233 results on '"Cicconetti, Franco"'

51. Laser of lung cancer

Author

Cicconetti, Franco, Modini, Claudio, LA ROVERE, C, Medici, F, Bartolucci, Piero, and Stipa, Sergio

Published
1990

55. A New Multiparametric Classification in Lung Cancer Patients - S.M.I.G.

Author

Modini, Claudio, Albertucci, Mario, Cicconetti, Franco, Danesi, Donatella Tirindelli, Cristiani, Renzo, Botti, Claudio, Lasagni, Roberto Pasquali, and Stipa, Sergio

Abstract

The classification of bronchogenic carcinoma as a function of the prognosis is still an open field. The evaluation of stage, by use of the TNM system, and histologic cell type is not sufficient to guarantee a correct prognosis. The growth rate of the neoplasm is another important parameter. We propose a classification that takes into account the stage (S), histologic cell type (M), immune status (I) and the growth rate of the primary tumor (G): S.M.I.G. We studied 90 lung cancer patients according to the S.M.I.G. classification and we observed that their prognoses were directly correlated with their S.M.I.G. scores (the higher the score, the higher the 10-month mortality rate). The mortality rates within the first 10 months of follow-up were respectively 0%, 0%, 36.36%, 68%, 90.9% for the 5 groups obtained by S.M.I.G. The difference is statistically significant (P < 0.0075) and there is a linear correlation between the mortality rate and the score assigned to each group (R = 0.943; P < 0.05). The S.M.I.G. classification can predict the prognosis more efficiently than the usual classification (TNM) and histological cell type.

Published
1983
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56. TNM staging in lung cancer: Role of computed tomography

Author

Modini, Claudio, Passariello, Roberto, Iascone, Clemente, Cicconetti, Franco, Simonetti, Giovanni, Zerilli, Massimo, Tirindelli-Danesi, Donatella, and Stipa, Sergio

Abstract

Current procedures to determine the clinical staging of disease in patients with lung cancer are lacking in accuracy, particularly regarding the presence of metastatic disease. We have evaluated the use of computed tomography (CT) of the chest, brain, and upper abdomen for clinical staging of the extent of disease in 113 consecutive patients with histologically confirmed carcinoma of the lung. Comparisons with mediastinoscopy and surgical findings were made regarding the extent of primary tumor in 47 patients and nodal involvement in 41 patients. The CT scan showed a sensitivity of 86.9%, a specificity of 91.6%, and an accuracy of 89.3% for extrapulmonary extension of the primary tumor and a sensitivity of 50%, a specificity of 96.5% and an accuracy of 82.9% for mediastinal node involvement. Thirty-two of the 85 patients studied by total body CT scan had distant metastasis, of which 24 (75%) were clinically silent. Thus 28.2% of the 85 patients studied had asymptomatic metastatic disease. We conclude that CT of the chest, brain, and upper abdomen is a reliable procedure for staging lung cancer.

Published
1982
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57. Role of Delayed Cutaneous Hypersensitivity Reaction in Classifying Patients with Bronchial Carcinoma

Author

Modini, Claudio, Ziparo, Vincenzo, Cicconetti, Franco, Cristiani, Renzo, Caterino, Salvatore, Tirindelli-Danesi, Donatella, Aschelter, Anna Maria, and Stipa, Sergio

Abstract

Cell-mediated immune response was evaluated in 150 patients with histologically confirmed bronchopulmonary carcinoma using bacterial and fungal recall antigens injected intradermally (PFD, candidina, trichophyton). In the study group negative skin test reaction was found in 51 of 150 patients (34.0 %), whereas in the control population it was found in 5 of 33 cases (15.1 %) (p < 0.05). Histologic cell type and stage of disease were defined for each patient. It was possible to calculate the growth rate of the primary tumor only in 68 of 150 patients, and it was recorded as doubling time. Evaluation of the skin test reaction in each prognostic subgroup showed no statistically significant differences. The only statistically significant differences were found when each prognostic subgroup was compared with the control population according to the frequency of a negative response to the skin test, particularly in stage III M1 (p < 0.05) and stage III M0 (p < 0.02). The delayed cutaneous hypersensitivity studied with recall antigen stimulation was mainly correlated with the stage of disease, and it should not be considered as an independent prognostic factor.

Published
1985
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58. The Bronchopulmonary Carcinoma: Influence of Type of Resection on Long Term Survival.

Author

Modini, Claudio, Iascone, Clemente, Cicconetti, Franco, Zerilli, Massimo, and Stipa, Sergio

Abstract

A statistical comparison between survival and type of resection: Lobectomy and pneumonectomy was made out of 108 patients who had undergone curative resection for lung cancer (with a minimum 3 years follow-up). Analysis was first made on the whole series, then the patients were classified according to histological type (W-PL) or staging (TNM) and finally stratified in 2 control levels (stage and histological type). There was a better prognosis for lobectomy than for pneumonectomy, referring to a single subgroup, but not in a statistically significant way. There was a better prognosis for patients who had been operated for lobectomy S (2) 2 LOB with a 36 months survival for 85 %. There were better results for squamous cell carcinoma stage I and II S(2) 1 PNE, for those patients who had been operated for pneumonectomy with a median survival of 32 months and over 3 years survival for 41.7 %.

Published
1980
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