51. Anti-RH Immunoglobulin Therapy for Human Immunodeficiency Virus-Related Immune Thrombocytopenic Purpura
- Author
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Oksenhendler, Eric, Bierling, Philippe, Brossard, Yves, Schenmetzler, Claudine, Girard, Pierre-Marie, Seligmann, Maxime, and Clauvel, Jean-Pierre
- Abstract
The potential hazards of steroids in human immunodeficiency virus (HlV)-infected patients led us to evaluate the effectiveness and safety of anti-D and anti-c Ig in 17 adults with severe HIV-related immune thrombocytopenic purpura (platelet count < 20 x 109/L). The 14 Rh+ patients received 12 to 25 μg/kg of anti-D IgG intravenously on two consecutive days. A significant platelet rise above 50 x 109/L was obtained in nine patients. Repeated boosters were performed in six cases and were effective in all cases. The 3 Rh- patients had a good response after they were given 20 mL x 2 of plasma containing potent anti-c antibodies. Therapy was well tolerated, and only one patient had significant hemolysis. These data suggest that anti-Rh IgG can be effective and safe in HIV-related thrombocytopenic purpura and that a specific interaction between the RBC antigens and the anti-Rh antibodies is required.
- Published
- 1988
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