484 results on '"Conlon, Peter J"'
Search Results
52. Cancer survival in kidney transplant recipients in Ireland
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Murray, Susan L, primary, O’Leary, Eamonn, additional, De Bhailís, Áine M, additional, Deady, Sandra, additional, Daly, Fergus E, additional, O’Kelly, Patrick, additional, Williams, Yvonne, additional, O’Neill, James P, additional, Sexton, Donal J, additional, and Conlon, Peter J, additional
- Published
- 2020
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53. Integration of genetic and histopathology data in interpretation of kidney disease
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Murray, Susan L, primary, Fennelly, Neil K, additional, Doyle, Brendan, additional, Lynch, Sally Ann, additional, and Conlon, Peter J, additional
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- 2020
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54. Polygenic risk score of non‐melanoma skin cancer predicts post‐transplant skin cancer across multiple organ types
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Stapleton, Caragh P., primary, Chang, Bao‐Li, additional, Keating, Brendan J., additional, Conlon, Peter J., additional, and Cavalleri, Gianpiero L., additional
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- 2020
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55. Calcium and phosphate levels after kidney transplantation and long-term patient and allograft survival
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Chevarria, Julio, primary, Sexton, Donal J, additional, Murray, Susan L, additional, Adeel, Chaudhry E, additional, O’Kelly, Patrick, additional, Williams, Yvonne E, additional, O’Seaghdha, Conall M, additional, Little, Dilly M, additional, and Conlon, Peter J, additional
- Published
- 2020
- Full Text
- View/download PDF
56. Renal transplant outcomes in patients with autosomal dominant tubulointerstitial kidney disease
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Cormican, Sarah, primary, Kennedy, Claire, additional, Connaughton, Dervla M., additional, O'Kelly, Patrick, additional, Murray, Susan, additional, Živná, Martina, additional, Kmoch, Stanislav, additional, Fennelly, Neil K., additional, Benson, Katherine A., additional, Conlon, Eoin T., additional, Cavalleri, Gianpiero L., additional, Foley, Claire, additional, Doyle, Brendan, additional, Dorman, Anthony, additional, Little, Mark A., additional, Lavin, Peter, additional, Kidd, Kendrah, additional, Bleyer, Anthony J., additional, and Conlon, Peter J., additional
- Published
- 2020
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57. The impact of switching to mTOR inhibitor-based immunosuppression on long-term non-melanoma skin cancer incidence and renal function in kidney and liver transplant recipients
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Murray, Susan L., primary, Daly, Fergus E., additional, O’Kelly, Patrick, additional, O’Leary, Eamonn, additional, Deady, Sandra, additional, O’Neill, James P., additional, Dudley, Alexander, additional, Rutledge, Nicholas R., additional, McCormick, Aiden, additional, Houlihan, Diarmuid D., additional, Williams, Yvonne, additional, Morris, Patrick G., additional, Ni Raghallaigh, Siona, additional, Moloney, Fergal J., additional, Sexton, Donal J., additional, and Conlon, Peter J., additional
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- 2020
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58. The impact of peritransplant warfarin use on renal transplant outcome
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Connaughton, Dervla M., Phelan, Paul J., Scheult, Jansen, Maʼayeh, Marwan, OʼKelly, Patrick, Walshe, Joseph J., Magee, Colm, Little, Dilly, Hickey, David, Slaby, Jiri, and Conlon, Peter J.
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- 2010
59. An Exome Sequencing Study of 10 Families with IgA Nephropathy
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Stapleton, Caragh P., primary, Kennedy, Claire, additional, Fennelly, Neil K., additional, Murray, Susan L., additional, Connaughton, Dervla M., additional, Dorman, Anthony M., additional, Doyle, Brendan, additional, Cavalleri, Gianpiero L., additional, and Conlon, Peter J., additional
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- 2019
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60. Utility of Genomic Testing after Renal Biopsy
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Murray, Susan L., primary, Dorman, Anthony, additional, Benson, Katherine A., additional, Connaughton, Dervla M., additional, Stapleton, Caragh P., additional, Fennelly, Neil K., additional, Kennedy, Claire, additional, McDonnell, Ciara A., additional, Kidd, Kendrah, additional, Cormican, Sarah M., additional, Ryan, Louise A., additional, Lavin, Peter, additional, Little, Mark A., additional, Bleyer, Anthony J., additional, Doyle, Brendan, additional, Cavalleri, Gianpiero L., additional, Hildebrandt, Friedhelm, additional, and Conlon, Peter J., additional
- Published
- 2019
- Full Text
- View/download PDF
61. EBV-positive B cell cerebral lymphoma 12 years after sex-mismatched kidney transplantation: post-transplant lymphoproliferative disorder or donor-derived lymphoma?
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Phelan, Paul J., Murphy, Rory K.J., Farrell, Michael, O’Toole, Orna, Heffernan, Josie, O’Brien, Donncha, Breathnach, Oscar, and Conlon, Peter J.
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- 2010
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62. Karyomegalic Interstitial Nephritis: Cancer Risk Following Transplantation
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Murray, Susan L., primary, Connaughton, Dervla M., additional, Fennelly, Neil K., additional, Kay, Elaine W., additional, Dorman, Anthony, additional, Doyle, Brendan, additional, and Conlon, Peter J., additional
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- 2019
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63. Left versus right deceased donor renal allograft outcome
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Phelan, Paul J., Shields, William, O’Kelly, Patrick, Pendergrass, Melissa, Holian, John, Walshe, Joseph J., Magee, Colm, Little, Dilly, Hickey, David, and Conlon, Peter J.
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- 2009
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64. Progression of renal artery stenosis in patients undergoing cardiac catheterization
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Crowley, James J., Santos, Renato M., Peter, Robert H., Puma, Joseph A., Schwab, Steve J., Phillips, Harry R., Stack, Richard S., and Conlon, Peter J.
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Arteries -- Stenosis ,Renal artery obstruction -- Development and progression ,Cardiac patients -- Physiological aspects ,Health - Published
- 1998
65. Successful Endovascular Treatment of a Hemodialysis Graft Pseudoaneurysm by Covered Stent and Direct Percutaneous Thrombin Injection
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Keeling, Aoife N., Naughton, Peter A., McGrath, Frank P., Conlon, Peter J., and Lee, Michael J.
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- 2008
66. Reduced graft function (with or without dialysis) vs immediate graft function—a comparison of long-term renal allograft survival
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Johnston, Olwyn, O'Kelly, Patrick, Spencer, Susan, Donohoe, John, Walshe, J. Joseph, Little, Dilly M., Hickey, David, and Conlon, Peter J.
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- 2006
67. The impact of donor spontaneous intracranial haemorrhage vs. other donors on long-term renal graft and patient survival
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Johnston, Olwyn, OʼKelly, Patrick, Spencer, Susan, Cunningham, Phyllis, Dorman, Anthony, Donohoe, John, Walshe, Joseph J, Hickey, David, Little, Dilly M, and Conlon, Peter J
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- 2006
68. A Comparison of Long-Term Graft Survival Rates Between the First and Second Donor Kidney Transplanted—The Effect of a Longer Cold Ischaemic Time for the Second Kidney
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Giblin, Louise, OʼKelly, Patrick, Little, Dillie, Hickey, David, Donohue, John, Walshe, Joseph J., Spencer, Susan, and Conlon, Peter J.
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- 2005
69. Introduction
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Hannan, Kieran, primary and Conlon, Peter J, additional
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- 2000
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70. Aspergillus ‘fungus ball’ within a cadaveric renal transplant graft
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Johnston, Olwyn, Little, Dilly M., Hickey, David, and Conlon, Peter J.
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- 2004
71. Linkage of a Gene Causing Familial Membranoproliferative Glomerulonephritis Type III to Chromosome 1
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Neary, John J., Conlon, Peter J., Croke, David, Dorman, Anthony, Keogan, Mary, Zhang, Feng Yu, Vance, Jeffery M., Pericak-Vance, Margaret A., Scott, William K., and Winn, Michelle P.
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- 2002
72. The Effect of Pre-existing Ischaemic Heart Disease on Renal Dysfunction in Cardiac Transplant Recipients
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Abraham, Kottarathil A., McGorrian, Catherine, OʼKelly, Patrick, Neligan, Maurice, Woods, Alfred E., Conlon, Peter J., and Donohoe, John
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- 2002
73. Long-term vascular access
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Conlon, Peter J, primary and Schwab, Steve J, additional
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- 1998
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74. A prospective study of complications associated with cuffed, tunnelled haemodialysis catheters†
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Little, Mark A., OʼRiordan, Aisling, Lucey, Brian, Farrell, Michael, Lee, Michael, Conlon, Peter J., and Walshe, J. Joseph
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- 2001
75. Effect of fluvastatin on acute renal allograft rejection: A randomized multicenter trial
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Holdaas, Hallvard, Jardine, Alan G., Wheeler, David C., Brekke, Inge B., Conlon, Peter J., Fellstrøm, Bengt, Hammad, Abdel, Holme, Ingar, Isoniemi, Helena, Moore, Richard, Rowe, Peter A., Sweny, Paul, Talbot, David A., Wadstrøm, Jonas, and Østraat, Øyvind
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- 2001
76. Severity of renal vascular disease predicts mortality in patients undergoing coronary angiography
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Conlon, Peter J., Little, Mark A., Pieper, Karen, and Mark, Daniel B.
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- 2001
77. Design and Implementation of the International Genetics and Translational Research in Transplantation Network
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Keating, Brendan J., van Setten, Jessica, Jacobson, Pamala A., Holmes, Michael V., Verma, Shefali S., Chandrupatla, Hareesh R., Nair, Nikhil, Gao, Hui, Li, Yun R., Chang, Bao-Li, Wong, Chanel, Phillips, Randy, Cole, Brian S., Mukhtar, Eyas, Zhang, Weijia, Cao, Hongzhi, Mohebnasab, Maede, Hou, Cuiping, Lee, Takesha, Steel, Laura, Shaked, Oren, Garifallou, James, Miller, Michael B., Karczewski, Konrad J., Akdere, Abdullah, Gonzalez, Ana, Lloyd, Kelsey M., McGinn, Daniel, Michaud, Zach, Colasacco, Abigail, Lek, Monkol, Fu, Yao, Pawashe, Mayur, Guettouche, Toumy, Himes, Aubree, Perez, Leat, Guan, Weihua, Wu, Baolin, Schladt, David, Menon, Madhav, Zhang, Zhongyang, Tragante, Vinicius, de Jonge, Nicolaas, Otten, Henny G., de Weger, Roel A., van de Graaf, Ed A., Baan, Carla C., Manintveld, Olivier C., De Vlaminck, Iwijn, Piening, Brian D., Strehl, Calvin, Shaw, Mary, Snieder, Harold, Klintmalm, Goran B., O'Leary, Jacqueline G., Amaral, Sandra, Goldfarb, Samuel, Rand, Elizabeth, Rossano, Joseph W., Kohli, Utkarsh, Heeger, Peter, Stahl, Eli, Christie, Jason D., Fuentes, Maria Hernandez, Levine, John E., Aplenc, Richard, Schadt, Eric E., Stranger, Barbara E., Kluin, Jolanda, Potena, Luciano, Zuckermann, Andreas, Khush, Kiran, Alzahrani, Alhusain J., Al-Muhanna, Fahad A., Al-Ali, Amein K., Al-Ali, Rudaynah, Al-Rubaish, Abdullah M., Al-Mueilo, Samir, Byrne, Edna M., Miller, David, Alexander, Stephen I., Onengut-Gumuscu, Suna, Rich, Stephen S., Suthanthiran, Manikkam, Tedesco, Helio, Saw, Chee L., Ragoussis, Jiannis, Kfoury, Abdallah G., Horne, Benjamin, Carlquist, John, Gerstein, Mark B., Reindl-Schwaighofer, Roman, Oberbauer, Rainer, Wijmenga, Cisca, Palmer, Scott, Pereira, Alexandre C., Segovia, Javier, Alonso-Pulpon, Luis A., Comez-Bueno, Manuel, Vilches, Carlos, Jaramillo, Natalia, de Borst, Martin H., Naesens, Maarten, Hao, Ke, MacArthur, DanielG., Balasubramanian, Suganthi, Conlon, Peter J., Lord, Graham M., Ritchie, Marylyn D., Snyder, Michael, Olthoff, Kim M., Moore, Jason H., Petersdorf, Effie W., Kamoun, Malek, Wang, Jun, Monos, Dimitri S., de Bakker, Paul I. W., Hakonarson, Hakon, Murphy, Barbara, Lankree, Matthew B., Garcia-Pavia, Pablo, Oetting, William S., Birdwell, Kelly A., Bakker, Stephan J. L., Israni, Ajay K., Shaked, Abraham, Asselbergs, Folkert W., Life Course Epidemiology (LCE), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Groningen Kidney Center (GKC), Lifestyle Medicine (LM), Vascular Ageing Programme (VAP), Groningen Institute for Organ Transplantation (GIOT), Gastroenterology & Hepatology, Dermatology, Erasmus MC other, Internal Medicine, Cardiology, and Cardiothoracic Surgery
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Graft Rejection ,International Cooperation ,Genome-wide association study ,030230 surgery ,VARIANTS ,Organ transplantation ,Organizational ,Translational Research, Biomedical ,0302 clinical medicine ,Models ,Risk Factors ,Databases, Genetic ,Medicine ,CARDIAC TRANSPLANTATION ,Cooperative Behavior ,Non-U.S. Gov't ,Translational Medical Research ,Genetics ,0303 health sciences ,Research Support, Non-U.S. Gov't ,Graft Survival ,Single Nucleotide ,Original Clinical Science—General ,3. Good health ,GENOTYPE ,surgical procedures, operative ,Phenotype ,Treatment Outcome ,Research Design ,Genetic Markers ,medicine.medical_specialty ,Primary Graft Dysfunction ,Translational research ,Human leukocyte antigen ,Research Support ,DONOR ,Polymorphism, Single Nucleotide ,N.I.H ,03 medical and health sciences ,Databases ,Genetic ,SDG 3 - Good Health and Well-being ,Research Support, N.I.H., Extramural ,Journal Article ,Humans ,Genetic Predisposition to Disease ,GENOME-WIDE ASSOCIATION ,PRIMARY GRAFT DYSFUNCTION ,Genetic Association Studies ,030304 developmental biology ,Genetic association ,Transplantation ,business.industry ,ELECTRONIC MEDICAL-RECORDS ,Extramural ,Organ Transplantation ,Genetic architecture ,POLYMORPHISM ,RECIPIENTS ,Models, Organizational ,Sample Size ,KIDNEY ALLOGRAFT FUNCTION ,business - Abstract
Background Genetic association studies of transplantation outcomes have been hampered by small samples and highly complex multifactorial phenotypes, hindering investigations of the genetic architecture of a range of comorbidities which significantly impact graft and recipient life expectancy. We describe here the rationale and design of the International Genetics & Translational Research in Transplantation Network. The network comprises 22 studies to date, including 16494 transplant recipients and 11669 donors, of whom more than 5000 are of non-European ancestry, all of whom have existing genomewide genotype data sets. Methods We describe the rich genetic and phenotypic information available in this consortium comprising heart, kidney, liver, and lung transplant cohorts. Results We demonstrate significant power in International Genetics & Translational Research in Transplantation Network to detect main effect association signals across regions such as the MHC region as well as genomewide for transplant outcomes that span all solid organs, such as graft survival, acute rejection, new onset of diabetes after transplantation, and for delayed graft function in kidney only. Conclusions This consortium is designed and statistically powered to deliver pioneering insights into the genetic architecture of transplant-related outcomes across a range of different solid-organ transplant studies. The study design allows a spectrum of analyses to be performed including recipient-only analyses, donor-recipient HLA mismatches with focus on loss-of-function variants and nonsynonymous single nucleotide polymorphisms., iGeneTRAiN is a consortium that has genome-wide genotype datasets. These genomic data allows robust statistically analysis of genetic associations that impact graft and patients variables such as, such as: graft survival, acute rejection, new onset of diabetes after transplantation, and delayed graft kidney function. Supplemental digital content is available in the text.
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- 2015
78. Calcium and phosphate levels after kidney transplantation and long-term patient and allograft survival.
- Author
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Chevarria, Julio, Sexton, Donal J, Murray, Susan L, Adeel, Chaudhry E, O'Kelly, Patrick, Williams, Yvonne E, O'Seaghdha, Conall M, Little, Dilly M, and Conlon, Peter J
- Subjects
CALCIUM phosphate ,KIDNEY transplantation ,CARDIOVASCULAR diseases risk factors ,BODY mass index ,SURVIVAL analysis (Biometry) - Abstract
Background Non-traditional cardiovascular risk factors, including calcium and phosphate derangement, may play a role in mortality in renal transplant. The data regarding this effect are conflicting. Our aim was to assess the impact of calcium and phosphate derangements in the first 90 days post-transplant on allograft and recipient outcomes. Methods We performed a retrospective cohort review of all-adult, first renal transplants in the Republic of Ireland between 1999 and 2015. We divided patients into tertiles based on serum phosphate and calcium levels post-transplant. We assessed their effect on death-censored graft survival and all-cause mortality. We used Stata for statistical analysis and did survival analysis and spline curves to assess the association. Results We included 1525 renal transplant recipients. Of the total, 86.3% had hypophosphataemia and 36.1% hypercalcaemia. Patients in the lowest phosphate tertile were younger, more likely female, had lower weight, more time on dialysis, received a kidney from a younger donor, had less delayed graft function and better transplant function compared with other tertiles. Patients in the highest calcium tertile were younger, more likely male, had higher body mass index, more time on dialysis and better transplant function. Adjusting for differences between groups, we were unable to show any difference in death-censored graft failure [phosphate = 1.14, 95% confidence interval (CI) 0.92–1.41; calcium = 0.98, 95% CI 0.80–1.20] or all-cause mortality (phosphate = 1.10, 95% CI 0.91–1.32; calcium = 0.96, 95% CI 0.81–1.13) based on tertiles of calcium or phosphate in the initial 90 days. Conclusions Hypophosphataemia and hypercalcaemia are common occurrences post-kidney transplant. We have identified different risk factors for these metabolic derangements. The calcium and phosphate levels exhibit no independent association with death-censored graft failure and mortality. [ABSTRACT FROM AUTHOR]
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- 2021
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79. Spectrum of disease in familial focal and segmental glomerulosclerosis
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Conlon, Peter J., Lynn, Kelvin, Winn, Michelle P., Quarles, L. Darryl, Bembe, Mary Lou, Pericak-Vance, Margaret, Speer, Marcy, and Howell, David N.
- Published
- 1999
80. Clinical and genetic heterogeneity in familial focal segmental glomerulosclerosis
- Author
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Winn, Michelle P., Conlon, Peter J., Lynn, Kelvin L., Howell, David N., Gross, Deborah A., Rogala, Allison R., Smith, Anne H., Graham, Felicia L., Bembe, MaryLou, Quarles, L. Daryl, Pericak-Vance, Margaret A., and Vance, Jeffery M.
- Published
- 1999
81. Effective Role of CVVH in Fatal Phenobarbital Overdose Clearance: A Case Report
- Author
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Ebad Chaudhry Adeel, Gaffney Alan, and Conlon Peter J
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Phenobarbital overdose ,business.industry ,Anesthesia ,Medicine ,business - Published
- 2018
82. A population-based comparison of organ transplant recipients in whom cutaneous squamous cell develops versus those in whom basal cell carcinoma develops.
- Author
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Menzies, Stephanie, O'Leary, Eamon, Callaghan, Grainne, Mansoor, Nazish, Deady, Sandra, Murad, Aizuri, Lenane, Patsy, O'Neill, Jim, Lally, Aoife, Houlihan, Diarmuid D., Murray, Susan, Sexton, Donal J., McCormick, P. Aiden, Egan, Jim J., O'Neill, James Paul, Conlon, Peter J., and Moloney, Fergal J.
- Published
- 2022
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83. Post‐transplant malignancy in solid organ transplant recipients in Ireland, The Irish Transplant Cancer Group
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O'Neill, James Paul, primary, Sexton, Donal J., additional, O'Leary, Eamonn, additional, O'Kelly, Patrick, additional, Murray, Susan, additional, Deady, Sandra, additional, Daly, Fergus, additional, Williams, Yvonne, additional, Dean, Ben, additional, Fitzgerald, Conall, additional, Murad, Aizuri, additional, Mansoor, Nazish, additional, O'Neill, Jim O., additional, Egan, Jim, additional, Houlihan, Diarmaid D., additional, McCormick, P. Aiden, additional, Morris, Patrick G., additional, Ni Raghallaigh, Siona, additional, Little, Dilly, additional, Moloney, Fergal J., additional, and Conlon, Peter J., additional
- Published
- 2019
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84. Progressive improvement in short‐, medium‐ and long‐term graft survival in kidney transplantation patients in Ireland – a retrospective study
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Sexton, Donal J., primary, O'Kelly, Patrick, additional, Williams, Yvonne, additional, Plant, William D., additional, Keogan, Marie, additional, Khalib, Khairin, additional, Doyle, Brendan, additional, Dorman, Anthony, additional, Süsal, Caner, additional, Unterrainer, Christian, additional, Forde, James, additional, Power, Richard, additional, Smith, Gordon, additional, Mohan, Ponnusamy, additional, Denton, Mark, additional, Magee, Colm, additional, de Freitas, Declan G., additional, Little, Dilly, additional, O'Seaghdha, Conall M., additional, and Conlon, Peter J., additional
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- 2019
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85. Variation in Nonmelanoma Skin Cancer Incidence by Treatment Modality Among Patients Receiving Multiple Kidney Transplants
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Sexton, Donal J., primary, O’Kelly, Patrick, additional, O’Leary, Eamonn, additional, Murray, Susan, additional, Deady, Sandra, additional, Daly, Fergus, additional, Egan, Jim, additional, Houlihan, Diarmaid D., additional, McCormick, P. Aiden, additional, Morris, Patrick G., additional, Ni Raghallaigh, Siona, additional, Moloney, Fergal J., additional, O’Neill, James Paul, additional, and Conlon, Peter J., additional
- Published
- 2019
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86. Monogenic causes of chronic kidney disease in adults
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Connaughton, Dervla M., primary, Kennedy, Claire, additional, Shril, Shirlee, additional, Mann, Nina, additional, Murray, Susan L., additional, Williams, Patrick A., additional, Conlon, Eoin, additional, Nakayama, Makiko, additional, van der Ven, Amelie T., additional, Ityel, Hadas, additional, Kause, Franziska, additional, Kolvenbach, Caroline M., additional, Dai, Rufeng, additional, Vivante, Asaf, additional, Braun, Daniela A., additional, Schneider, Ronen, additional, Kitzler, Thomas M., additional, Moloney, Brona, additional, Moran, Conor P., additional, Smyth, John S., additional, Kennedy, Alan, additional, Benson, Katherine, additional, Stapleton, Caragh, additional, Denton, Mark, additional, Magee, Colm, additional, O’Seaghdha, Conall M., additional, Plant, William D., additional, Griffin, Matthew D., additional, Awan, Atif, additional, Sweeney, Clodagh, additional, Mane, Shrikant M., additional, Lifton, Richard P., additional, Griffin, Brenda, additional, Leavey, Sean, additional, Casserly, Liam, additional, de Freitas, Declan G., additional, Holian, John, additional, Dorman, Anthony, additional, Doyle, Brendan, additional, Lavin, Peter J., additional, Little, Mark A., additional, Conlon, Peter J., additional, and Hildebrandt, Friedhelm, additional
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- 2019
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87. Assessing the discrimination of the Kidney Donor Risk Index/Kidney Donor Profile Index scores for allograft failure and estimated glomerular filtration rate in Ireland’s National Kidney Transplant Programme
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Sexton, Donal J, primary, O’Kelly, Patrick, additional, Kennedy, Claire, additional, Denton, Mark, additional, de Freitas, Declan G, additional, Magee, Colm, additional, O’Seaghdha, Conall M, additional, and Conlon, Peter J, additional
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- 2019
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88. Incidence and outcome of Staphylococcus aureus bacteremia in hemodialysis patients
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Marr, Kieren A., Kong, LiKuo, Fowler, Vance G., Gopal, Ajay, Sexton, Daniel J., Conlon, Peter J., and Corey, G. Ralph
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- 1998
89. Catheter-Related Bacteremia and Outcome of Attempted Catheter Salvage in Patients Undergoing Hemodialysis
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Marr, Kieren A., Sexton, Daniel J., Conlon, Peter J., Corey, G. Ralph, Schwab, Steven J., and Kirkland, Kathryn B.
- Published
- 1997
90. Renal Failure in the Intensive-Care Unit: An Old Tale Gets Better
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Conlon, Peter J. and Schwab, Steve J.
- Published
- 1996
91. Characterization of Monogenic Kidney Disease in Patients over 60 Years of Age
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Elhassan, Elhussein A., Benson, Katherine A., Cavalleri, Gianpiero, and Conlon, Peter J.
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- 2023
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92. Prospective Study of a Predictive Algorithm of Real-Time Fluid Status in Hemodialysis Patients
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Sandys, Vicki K., Bhat, Lavleen, Ninan, Anna, Doyle, Kevin, Conlon, Peter J., Sexton, Donal J., and O'Seaghdha, Conall M.
- Published
- 2023
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93. Ultra-Long Survivors of Kidney Transplantation: 40 Years and More of Graft Function
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Madden, Michelle, Comerford, Gavin, O'kelly, Patrick, Cooney, Anne M., and Conlon, Peter J.
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- 2023
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94. Variant renal artery anatomy in first degree relatives on MDCT angiography.
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Reid, Conor, Kelly, Dearbhla, Briody, Hayley, Lawless, Philip, Little, Dilly, Conlon, Peter J., and Morrin, Martina
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RENAL artery ,ANATOMY ,ANGIOGRAPHY ,MULTIDETECTOR computed tomography ,KIDNEY exchange - Abstract
Dear Editor, Since the widespread adoption of multidetector computed tomography (MDCT) angiography for pre-operative assessment of living kidney donors, significant variability in renal vascular anatomy has been identified. Given the frequency of living kidney donation at the Irish National Kidney Transplant Service, we recognized an opportunity to assess the incidence of variant renal anatomy in first degree relatives undergoing potential living donor workup. Complex living donor kidneys are used successfully at many centers and still outperform deceased donor kidneys in the long-term.[3] We wish to open up the discussion of the concordance of complex vascular anatomy among first degree relatives as we believe this will be of interest to your readership. [Extracted from the article]
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- 2023
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95. Predictors of prognosis and risk of acute renal failure in patients with Rocky Mountain spotted fever
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Conlon, Peter J., Procop, Gary W., Fowler, Vance, Eloubeidi, Mohamed Ali, Smith, Stephen R., and Sexton, Daniel J.
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Rocky Mountain spotted fever -- Prognosis ,Acute renal failure -- Risk factors ,Health ,Health care industry - Abstract
BACKGROUND: Acute renal failure has long been associated with severe Rocky Mountain spotted fever (RMSF). Despite many descriptions of the protean manifestations of this disease, relatively little is known concerning the risk factors for acute renal failure. Only a few studies have examined the outcome of patients infected with Rickettsia rickettsii who develop renal insufficiency, and these studies had methodological problems. OBJECTIVE: To study the incidence, risk factors, and outcomes of acute renal failure in a large group of hospitalized patients with definite or probable RMSF. METHODS: The clinical records of 114 patients with definite or probable RMSF were retrospectively reviewed to identify clinical and biochemical abnormalities at the time of admission that were associated with the development of acute renal failure and subsequent mortality. Renal failure was defined as a serum creatinine (Cr) above 2 mg/dL. Logistic regression was used to study the association between these variables and the outcomes during hospitalization: death and the development of acute renal failure. RESULTS: The mortality rate in this series was 14%; 19% of the patients developed acute renal failure. The development of acute renal failure increased the odds ratio (OR) of dying by a factor of 17 (P = 0.0001). Factors at the time of hospitalization that were associated at a univariate level with subsequent mortality included elevated serum Cr, increased age, increased level of AST, increased level of bilirubin, decreased serum sodium and platelet count, the presence of neurological involvement, and being male. Both the presence of neurological involvement and an elevated serum Cr at presentation were independently associated with increased mortality by multivariate analysis. Three patients developed acute renal failure that required hemodialysist and only 1 of these 3 patients survive ultimately discharged with a normal serum Cr. Factors at presentation that were associated with the development of acute renal failure included increased bilirubin, increasing age, thrombocytopenia, and the presence of neurological involvement. Both age and decreased platelet count at presentation were independently associated with the development of acute renal failure by multivariate analysis. CONCLUSION: Acute renal failure was a frequent complication of RMSF in this series of patients from a tertiary referral medical center. The presence of acute renal failure was strongly associated with death. Clinical and biochemical variables are useful in predicting which patients will develop acute renal failure. 1996 by Excerpta Medica, Inc. Am J Med. 1996;101:621-626.
- Published
- 1996
96. Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index
- Author
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Hinney, A., Kesselmeier, M., Huckins, Laura M, Hauser, Joanna, Karhunen, Leila, Meulenbelt, Ingrid, Slagboom, P Eline, Tortorella, Alfonso, Maj, Mario, Dedoussis, George, Dikeos, Dimitris, Gonidakis, Fragiskos, Tziouvas, Konstantinos, Southam, Lorraine, Tsitsika, Artemis, Papezova, Hana, Slachtova, Lenka, Martaskova, Debora, Kennedy, James L, Levitan, Robert D, Yilmaz, Zeynep, Huemer, Julia, Koubek, Doris, Merl, Elisabeth, Rayner, N William, Wagner, Gudrun, Lichtenstein, Paul, Breen, Gerome, Cohen-Woods, Sarah, Farmer, Anne, McGuffin, Peter, Cichon, Sven, Giegling, Ina, Herms, Stefan, Rujescu, Dan, Tachmazidou, Ioanna, Schreiber, Stefan, Wichmann, H-Erich, Dina, Christian, Sladek, Rob, Gambaro, Giovanni, Soranzo, Nicole, Julia, Antonio, Marsal, Sara, Rabionet, Raquel, Gaborieau, Valerie, Klump, Kelly L, Dick, Danielle M, Palotie, Aarno, Ripatti, Samuli, Widén, Elisabeth, Andreassen, Ole A, Espeseth, Thomas, Lundervold, Astri, Reinvang, Ivar, Steen, Vidar M, Hellard, Stephanie Le, Treasure, Janet, Mattingsdal, Morten, Ntalla, Ioanna, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Navratilova, Marie, Gallinger, Steven, Pinto, Dalila, Scherer, Stephen W, Aschauer, Harald, Lewis, Cathryn M, Carlberg, Laura, Schosser, Alexandra, Alfredsson, Lars, Ding, Bo, Klareskog, Lars, Padyukov, Leonid, Finan, Chris, Kalsi, Gursharan, Roberts, Marion, Logan, Darren W, Schmidt, Ulrike, Peltonen, Leena, Ritchie, Graham R S, Barrett, Jeff C, Estivill, Xavier, Hinney, Anke, Sullivan, Patrick F, Collier, David A, Zeggini, Eleftheria, Bulik, Cynthia M, Anderson, Carl A, Tozzi, Federica, Barrett, Jeffrey C, Floyd, James A B, Franklin, Christopher S, McGinnis, Ralph, Sambrook, Jennifer, Stephens, Jonathan, Ouwehand, Willem H, McArdle, Wendy L, iezebrink, Kirsty, Ring, Susan M, Strachan, David P, Alexander, Graeme, Conlon, Peter J, Dominiczak, Anna, Duncanson, Audrey, Hill, Adrian, Langford, Cordelia, Jall, S., Hebebrand, Johannes, Lord, Graham, Maxwell, Alexander P, Morgan, Linda, Sandford, Richard N, Sheerin, Neil, Vannberg, Frederik O, Blackburn, Hannah, Chen, Wei-Min, Edkins, Sarah, Gorwood, Philip, Gillman, Mathew, Gray, Emma, Hunt, Sarah E, Nengut-Gumuscu, Suna, Potter, Simon, Rich, Stephen S, Simpkin, Douglas, Whittaker, Pamela, Heid, I. M., Winkler, T. W., Adan, Roger A H, de Bakker, P., Bültmann, U., Geleijnse, M., Harst, P. V., Koppelman, G., Rosmalen, J. G., van Rossum, L., Smidt, H., Swertz, M. A., Stolk, R. P., Kas, Martien J H, Alizadeh, B., de Boer, R., Boezen, H. M., Bruinenberg, M., Franke, L., van der Harst, P., Hillege, H., van der Klauw, M., Navis, G., Ormel, J., Favaro, Angela, Postma, D., Rosmalen, J., Slaets, J., Snieder, H., Stolk, R., Wolffenbuttel, B., Wijmenga, C., Berg, J., Blackwood, D., Campbell, H., Santonastaso, Paolo, Cavanagh, J., Connell, J., Connor, M., Cunningham-Burley, S., Deary, I., Dominiczak, A., Ellis, P., FitzPatrick, B., Ford, I., Gertz, R., Fernández-Aranda, Fernando, Grau, A., Haddow, G., Jackson, C., Kerr, S., Lindsay, R., McGilchrist, M., McIntyre, D., Morris, A., Morton, R., Muir, W., Gratacos, Monica, Murray, G., Palmer, C., Pell, J., Philp, A., Porteous, D., Porteous, M., Procter, R., Ralston, S., Reid, D., Sinnott, R., Rybakowski, Filip, Smith, B., Clair, D. S., Sullivan, F., Sweetland, M., Ure, J., Watt, G., Wolf, R., Wright, A., Berndt, S. I., Gustafsson, S., Dmitrzak-Weglarz, Monika, Mägi, R., Ganna, A., Wheeler, E., Feitosa, M. F., Justice, A. E., Monda, K. L., Croteau- Chonka, D. C., Day, F. R., Esko, T., Fall, T., Volckmar, A-L, Kaprio, Jaakko, Ferreira, T., Gentilini, D., Jackson, A. U., Luan, J., Randall, J. C., Vedantam, S., Willer, C. J., Wood, A. R., Workalemahu, T., Keski-Rahkonen, Anna, Hu, Y. J., Lee, S. H., Liang, L., Lin, D. Y., Min, J. L., Neale, B. M., Thorleifsson, G., Yang, J., Albrecht, E., Amin, N., Raevuori-Helkamaa, Anu, Bragg-Gresham, J. L., Cadby, G., den Heijer, M., Eklund, N., Fischer, K., Goel, A., Hottenga, J. J., Huffman, J. E., Jarick, I., Johansson, A., Van Furth, Eric F, Johnson, T., Kanoni, S., Kleber, M. E., König, I. R., Kristiansson, K., Kutalik, Z., Lamina, C., Lecoeur, C., Li, G., Mangino, M., Slof-Op't Landt, Margarita C T, McArdle, W. L., Medina-Gomez, C., Müller-Nurasyid, M., Ngwa, J. S., Nolte, I. M., Paternoster, L., Pechlivanis, S., Perola, M., Peters, M. J., Preuss, M., Hudson, James I, Rose, L. M., Shi, J., Shungin, D., Smith, A. V., Strawbridge, R. J., Surakka, I., Teumer, A., Trip, M. D., Tyrer, J., Van Vliet- Ostaptchouk, J. V., Reichborn-Kjennerud, Ted, Vandenput, L., Waite, L. L., Zhao, J. H., Absher, D., Asselbergs, F. W., Atalay, M., Attwood, A. P., Balmforth, A. J., Basart, H., Beilby, J., Knudsen, Gun Peggy S, Bonnycastle, L. L., Brambilla, P., Chasman, D. I., Chines, P. S., Collins, F. S., Connell, J. M., Cookson, W., de Faire, U., Monteleone, Palmiero, de Vegt, F., Dei, M., Dimitriou, M., Edkins, S., Estrada, K., Evans, D. M., Farrall, M., Ferrario, M. M., Ferrières, J., Kaplan, Allan S, Frau, F., Gejman, P. V., Grallert, H., Grönberg, H., Gudnason, V., Hall, A. S., Hall, P., Hartikainen, A. L., Hayward, C., Heard-Costa, N. L., Föcker, M., Karwautz, Andreas, Heath, A. C., Hebebrand, J., Homuth, G., Hu, F. B., Hunt, S. E., Hyppönen, E., Iribarren, C., Jacobs, K. B., Jansson, J. O., Jula, A., Hakonarson, Hakon, Kähönen, M., Kathiresan, S., Kee, F., Khaw, K. T., Kivimaki, M., Koenig, W., Kraja, A. T., Kumari, M., Kuulasmaa, K., Kuusisto, J., Berrettini, Wade H, Laitinen, J. H., Lakka, T. A., Langenberg, C., Launer, L. J., Lind, L., Lindström, J., Liu, J., Liuzzi, A., Lokki, M. L., Lorentzon, M., Guo, Yiran, Madden, P. A., Magnusson, P. K., Manunta, P., Marek, D., März, W., Mateo Leach, I., McKnight, B., Medland, S. E., Mihailov, E., Milani, L., Li, Dong, Montgomery, G. W., Mooser, V., Mühleisen, T. W., Munroe, P. B., Musk, A. W., Narisu, N., Nicholson, G., Nohr, E. A., Ong, K. K., Schork, Nicholas J, Oostra, B. A., Palmer, C. N., Palotie, A., Peden, J. F., Pedersen, N., Peters, A., Polasek, O., Pouta, A., Pramstaller, P. P., Prokopenko, I., Komaki, Gen, Pütter, C., Radhakrishnan, A., Raitakari, O., Rendon, A., Rivadeneira, F., Rudan, I., Saaristo, T. E., Sambrook, J. G., Sanders, A. R., Sanna, S., Ando, Tetsuya, Saramies, J., Schipf, S., Schreiber, S., Schunkert, H., Shin, S. Y., Signorini, S., Sinisalo, J., Skrobek, B., Soranzo, N., Stancakova, A., Inoko, Hidetoshi, Stark, K., Stephens, J. C., Stirrups, K., Stumvoll, M., Swift, A. J., Theodoraki, E. V., Thorand, B., Tregouet, D. A., Tremoli, E., Esko, Tõnu, Van der Klauw, M. M., van Meurs, J. B., Vermeulen, S. H., Viikari, J., Virtamo, J., Vitart, V., Waeber, G., Wang, Z., Widen, E., Wild, S. H., Antel, J., Fischer, Krista, Willemsen, G., Winkelmann, B. R., Witteman, J. C., Wolffenbuttel, B. H., Wong, A., Wright, A. F., Zillikens, M., Amouyel, P., Boehm, B. O., Boerwinkle, E., Männik, Katrin, Boomsma, D. I., Caulfield, M. J., Chanock, S. J., Cupples, L., Cusi, D., Dedoussis, G. V., Erdmann, J., Eriksson, J. G., Franks, P. W., Froguel, P., Metspalu, Andres, Gieger, C., Gyllensten, U., Hamsten, A., Harris, T. B., Hengstenberg, C., Hicks, A. A., Hingorani, A., Hofman, A., Hovingh, K. G., Baker, Jessica H, Hveem, K., Illig, T., Jarvelin, M. R., Jöckel, K. H., Keinanen-Kiukaanniemi, S. M., Kiemeney, L. A., Kuh, D., Laakso, M., Lehtimäki, T., Levinson, D. F., Cone, Roger D, Martin, N. G., Metspalu, A., Morris, A. D., Nieminen, M. S., Njølstad, I., Ohlsson, C., Oldehinkel, A. J., Ouwehand, W. H., Palmer, L. J., Penninx, B., Dackor, Jennifer, Power, C., Province, M. A., Psaty, B. M., Qi, L., Rauramaa, R., Ridker, P. M., Ripatti, S., Salomaa, V., Samani, N. J., DeSocio, Janiece E, Sørensen, T. I., Spector, T. D., Stefansson, K., Tönjes, A., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., Vollenweider, P., Wallaschofski, H., Hilliard, Christopher E, Wareham, N. J., Watkins, H., Wichmann, H, Wilson, J. F., Abecasis, G. R., Assimes, T. L., Barroso, I., Boehnke, M., Borecki, I. B., Deloukas, P., O'Toole, Julie K, Fox, C. S., Frayling, T., Groop, L. C., Haritunian, T., Hunter, D., Kaplan, R. C., Karpe, F., Moffatt, M., Mohlke, K. L., Pantel, Jacques, O'Connell, J. R., Pawitan, Y., Schadt, E. E., Schlessinger, D., Steinthorsdottir, V., Strachan, D. P., Thorsteinsdottir, U., van Duijn, C. M., Visscher, P. M., Di Blasio, A. M., Perica, Vesna Boraska, Szatkiewicz, Jin P, Hirschhorn, J. N., Lindgren, C. M., Morris, A. P., Meyre, D., Scherag, A., McCarthy, M. I., Speliotes, E. K., North, K. E., Loos, R. J., Grant, S. F. A., Taico, Chrysecolla, Adair, L. S., Ang, W., van Beijsterveldt, T., Bergen, N., Benke, K., Berry, D. J., Bradfield, J. P., Charoen, P., Zerwas, Stephanie, Coin, L., Cooper, C., Cousminer, D. L., Das, S., Davis, O. S., Elliott, P., Estivill, X., Feenstra, B., Trace, Sara E, Flexeder, C., Freathy, R. M., Gaillard, R., Geller, F., Gillman, M., Grant, S. F., Groen-Blokhuis, M., Goh, L. K., Guxens, M., Davis, Oliver S P, Hakonarson, H., Hattersley, A. T., Haworth, C. M., Hadley, D., Heinrich, J., Hocher, B., Holloway, J. W., Helder, Sietske, Holst, C., Horikoshi, M., Huikari, V., Hypponen, E., Iñiguez, C., Jaddoe, V. W., Kaakinen, M., Kilpeläinen, T. O., Bühren, Katharina, Kirin, M., Kowgier, M., Lakka, H. M., Lange, L. A., Lawlor, D. A., Lewin, A., Lindgren, C., Lindi, V., Burghardt, Roland, Maggi, R., Marsh, J., Melbye, M., Middeldorp, C., Millwood, I., Mook-Kanamori, D. O., Murray, J. C., Nivard, M., de Zwaan, Martina, Ntalla, I., Oken, E., O'Reilly, P. F., Panoutsopoulou, K., Pararajasingham, J., Pearson, E. R., Pennell, C. E., Egberts, Karin, Price, T. S., Raitakari, O. T., Rodriguez, A., Salem, R. M., Saw, S. M., Sebert, S., Siitonen, N., Ehrlich, Stefan, Simell, O., Sovio, U., Pourcain, B. S., Sunyer, J., Taal, H. R., Teo, Y. Y., Thiering, E., Tiesler, C., Herpertz-Dahlmann, Beate, Timpson, N. J., Valcárcel, B., Warrington, N. M., White, S., Widén, E., Yaghootkar, H., Zeggini, E., Herzog, Wolfgang, Elks, C. E., Perry, J. R., Sulem, P., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Imgart, Hartmut, Gudbjartsson, D. F., Koller, D. L., Lin, P., Marongiu, M., McArdle, P. F., Scherag, André, Stolk, L., van Wingerden, S. H., Corre, T., Ingelsson, E., Smith, E. N., Scherag, Susann, Ulivi, S., Warrington, M., Zgaga, L., Alavere, H., Aspelund, T., Bandinelli, S., Berenson, G. S., Bergmann, S., Zipfel, Stephan, Blackburn, H., Buring, J. E., Busonero, F., Chen, W., Cornelis, M. C., Couper, D., Coviello, A. D., Boni, Claudette, d'Adamo, P., de Geus, E. J., Döring, A., Davey Smith, G., Easton, D. F., Eiriksdottir, G., Emilsson, V., Eriksson, J., Ramoz, Nicolas, Ferrucci, L., Folsom, A. R., Foroud, T., Garcia, M., Gasparini, P., Hankinson, S. E., Versini, Audrey, Ferreli, L., Hernandez, D. G., Järvelin, M. R., Johnson, A. D., Karasik, D., Brandys, Marek K, Kiel, D. P., Kolcic, I., Kraft, P., Laven, J. S., Li, S., Levy, D., Danner, Unna N, Murray, S. S., Nalls, M. A., Navarro, P., Nelis, M., Ness, A. R., Northstone, K., de Kove, Carolien, Peacock, M., Paré, G., Parker, A. N., Pedersen, N. L., Peltonen, L., Pharoah, P., Hendriks, Judith, Plump, A. S., Porcu, E., Rafnar, T., Rice, J. P., Ring, S. M., Sala, C., Koeleman, Bobby P C, Schork, N. J., Scuteri, A., Segrè, A. V., Shuldiner, A. R., Srinivasan, S. R., Ophoff, Roel A, Tammesoo, M. L., Tikkanen, E., Toniolo, D., Tsui, K., Tryggvadottir, L., Uda, M., van Dam, R. M., Strengman, Eric, Waterworth, D. M., Weedon, M. N., Wichmann, H. E., Young, L., van Elburg, Annemarie A, Zhai, G., Zhuang, W. V., Bierut, L. J., Boyd, H. A., Crisponi, L., Demerath, E. W., Econs, M. J., Hunter, D. J., Bruson, Alice, Streeten, E. A., Clementi, Maurizio, Murabito, J. M., Murray, A., Guo, Y., Bergen, A. W., Kaye, W., Berrettini, W., Brandt, Harry, Crawford, Steve, Thornton, Laura M, Degortes, Daniela, Crow, Scott, Fichter, Manfred M, Halmi, Katherine A, Johnson, Craig, Via, Maria La, Mitchell, James, Strober, Michael, Rotondo, Alessandro, Forzan, Monica, Woodside, D Blake, Keel, Pamela, Lilenfeld, Lisa, Plotnicov, Kathy, Bergen, Andrew W, Berrettini, Wade, Kaye, Walter, Tenconi, Elena, Magistretti, Pierre, Herpertz-Dahlmann, B., de Zwaan, M., Herzog, W., Ehrlich, S., Zipfel, S., Egberts, K. M., Adan, R., Brandys, M., van Elburg, A., Docampo, Elisa, Boraska Perica, V., Franklin, C. S., Tschöp, M. H., Bulik, C. M., Collier, D., Müller, T. D., Escaramí, Geòrgia, Jiménez-Murcia, Susana, Lissowska, Jolanta, Rajewski, Andrzej, Szeszenia-Dabrowska, Neonila, Slopien, Agnieszka, Hinney, A., Kesselmeier, M., Jall, S., Volckmar, A. -L., Focker, M., Antel, J., Heid, I. M., Winkler, T. W., Grant, S. F. A., Guo, Y., Bergen, A. W., Kaye, W., Berrettini, W., Hakonarson, H., Herpertz-Dahlmann, B., De Zwaan, M., Herzog, W., Ehrlich, S., Zipfel, S., Egberts, K. M., Adan, R., Brandys, M., Van Elburg, A., Boraska Perica, V., Muller, T. D., Tschop, M. H., Zeggini, E., Bulik, C. M., Collier, D., Scherag, A., Hebebrand, J., Perica, V. B., Floyd, J. A. B., Thornton, L. M., Huckins, L. M., Southam, L., Rayner, N. W., Tachmazidou, I., Klump, K. L., Treasure, J., Lewis, C. M., Schmidt, U., Tozzi, F., Iezebrink, K., Gorwood, P., Kas, M. J. H., Favaro, A., Santonastaso, P., Fernandez-Aranda, F., Gratacos, M., Rybakowski, F., Dmitrzak-Weglarz, M., Kaprio, J., Keski-Rahkonen, A., Raevuori-Helkamaa, A., Van Furth, E. F., Slof-Op't Landt, M. C. T., Hudson, J. I., Reichborn-Kjennerud, T., Knudsen, G. P. S., Monteleone, P., Kaplan, A. S., Karwautz, A., Li, D., Komaki, G., Ando, T., Inoko, H., Esko, T., Fischer, K., Mannik, K., Metspalu, A., Baker, J. H., Cone, R. D., Dackor, J., Desocio, J. E., Hilliard, C. E., O'Toole, J. K., Pantel, J., Szatkiewicz, J. P., Taico, C., Zerwas, S., Trace, S. E., Davis, O. S. P., Helder, S., Buhren, K., Burghardt, R., Imgart, H., Scherag, S., Boni, C., Ramoz, N., Versini, A., Danner, U. N., de Kove, C., Hendriks, J., Koeleman, B. P. C., Ophoff, R. A., Strengman, E., Bruson, A., Clementi, M., Degortes, D., Forzan, M., Tenconi, E., Docampo, E., Jimenez-Murcia, G. E. S., Lissowska, J., Rajewski, A., Szeszenia-Dabrowska, N., Slopien, A., Hauser, J., Karhunen, L., Meulenbelt, I., Slagboom, P. E., Tortorella, A., Maj, M., Dedoussis, G., Dedoussis, G. V., Dikeos, D., Gonidakis, F., Tziouvas, K., Tsitsika, A., Papezova, H., Slachtova, L., Martaskova, D., Kennedy, J. L., Levitan, R. D., Yilmaz, Z., Huemer, J., Koubek, D., Merl, E., Wagner, G., Lichtenstein, P., Breen, G., Cohen-Woods, S., Farmer, A., Mcguffin, P., Cichon, S., Giegling, I., Herms, S., Rujescu, D., Schreiber, S., Wichmann, H. -E., Christian, D., Sladek, R., Gambaro, G., Soranzo, N., Julia, A., Marsal, S., Rabionet, R., Gaborieau, V., Dick, D. M., Palotie, A., Ripatti, S., Widen, E., Andreassen, O. A., Espeseth, T., Lundervold, A., Reinvang, I., Steen, V. M., Le Hellard, S., Mattingsdal, M., Ntalla, I., Bencko, V., Foretova, L., Janout, V., Navratilova, M., Gallinger, S., Pinto, D., Scherer, S. W., Aschauer, H., Carlberg, L., Schosser, A., Alfredsson, L., Ding, B., Klareskog, L., Padyukov, L., Finan, C., Kalsi, G., Roberts, M., Logan, D. W., Peltonen, L., Ritchie, G. R. S., Barrett, J. C., Estivill, X., Sullivan, P. F., Anderson, C. A., Mcginnis, R., Sambrook, J., Stephens, J., Ouwehand, W. H., Mcardle, W. L., Mcardle, P. F., Ring, S. M., Strachan, D. P., Alexander, G., Conlon, P. J., Dominiczak, A., Duncanson, A., Hill, A., Langford, C., Lord, G., Maxwell, A. P., Morgan, L., Sandford, R. N., Sheerin, N., Vannberg, F. O., Chen, W. -M., Edkins, S., Gillman, M., Gray, E., Hunt, S. E., Nengut, S. -G., Potter, S., Rich, S. S., Simpkin, D., Whittaker, P., Adair, L. S., Ang, W., Atalay, M., van Beijsterveldt, T., Bergen, N., Benke, K., Berry, D. J., Boomsma, D. I., Bradfield, J. P., Charoen, P., Coin, L., Cooper, C., Cousminer, D. L., Das, S., Elliott, P., Evans, D. M., Feenstra, B., Flexeder, C., Frayling, T., Freathy, R. M., Gaillard, R., Geller, F., Groen-Blokhuis, M., Goh, L. K., Guxens, M., Hattersley, A. T., Haworth, C. M., Hadley, D., Heinrich, J., Hirschhorn, J. N., Hocher, B., Holloway, J. W., Holst, C., Hottenga, J. J., Horikoshi, M., Huikari, V., Hypponen, E., Iniguez, C., Jaddoe, V. W., Jarvelin, M. R., Kaakinen, M., Kilpelainen, T. O., Kirin, M., Kowgier, M., Lakka, H. M., Lakka, T. A., Lange, L. A., Lawlor, D. A., Lehtimaki, T., Lewin, A., Lindgren, C., Lindi, V., Maggi, R., Marsh, J., Mccarthy, M. I., Melbye, M., Middeldorp, C., Millwood, I., Mohlke, K. L., Mook-Kanamori, D. O., Murray, J. C., Nivard, M., Nohr, E. A., Oken, E., Ong, K. K., O'Reilly, P. F., Palmer, L. J., Panoutsopoulou, K., Pararajasingham, J., Pearson, E. R., Pennell, C. E., Power, C., Price, T. S., Prokopenko, I., Raitakari, O. T., Rodriguez, A., Salem, R. M., Saw, S. M., Sebert, S., Siitonen, N., Simell, O., Sorensen, T. I., Sovio, U., Pourcain, B. S., Sunyer, J., Taal, H. R., Teo, Y. Y., Thiering, E., Tiesler, C., Timpson, N. J., Uitterlinden, A. G., Valcarcel, B., Warrington, N. M., White, S., Willemsen, G., Wilson, J. F., Yaghootkar, H., Elks, C. E., Perry, J. R., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Gudbjartsson, D. F., Koller, D. L., Kutalik, Z., Lin, P., Mangino, M., Marongiu, M., Smith, A. V., Stolk, L., van Wingerden, S. H., Zhao, J. H., Albrecht, E., Corre, T., Ingelsson, E., Hayward, C., Magnusson, P. K., Smith, E. N., Ulivi, S., Warrington, M., Zgaga, L., Alavere, H., Amin, N., Aspelund, T., Bandinelli, S., Barroso, I., Berenson, G. S., Bergmann, S., Boerwinkle, E., Buring, J. E., Busonero, F., Campbell, H., Chanock, S. J., Cornelis, M. C., Couper, D., Coviello, A. D., D'Adamo, P., de Faire, U., de Geus, E. J., Deloukas, P., Doring, A., Davey Smith, G., Easton, D. F., Eiriksdottir, G., Emilsson, V., Eriksson, J., Ferrucci, L., Folsom, A. R., Foroud, T., Garcia, M., Gasparini, P., Gieger, C., Gudnason, V., Hall, P., Hankinson, S. E., Ferreli, L., Heath, A. C., Hernandez, D. G., Hofman, A., Hu, F. B., Illig, T., Karasik, D., Khaw, K. T., Kiel, D. P., Kolcic, I., Kraft, P., Launer, L. J., Laven, J. S., Li, S., Liu, J., Levy, D., Martin, N. G., Mooser, V., Murray, S. S., Nalls, M. A., Navarro, P., Nelis, M., Ness, A. R., Northstone, K., Oostra, B. A., Peacock, M., Pare, G., Parker, A. N., Pedersen, N. L., Pharoah, P., Polasek, O., Plump, A. S., Pouta, A., Porcu, E., Rafnar, T., Rice, J. P., Rivadeneira, F., Rudan, I., Sala, C., Salomaa, V., Sanna, S., Schlessinger, D., Scuteri, A., Segre, A. V., Shuldiner, A. R., Srinivasan, S. R., Tammesoo, M. L., Tikkanen, E., Toniolo, D., Tsui, K., Tryggvadottir, L., Tyrer, J., Uda, M., van Dam, R. M., van Meurs, J. B., Vollenweider, P., Waeber, G., Wareham, N. J., Waterworth, D. M., Weedon, M. N., Wright, A. F., Young, L., Zhai, G., Zhuang, W. V., Bierut, L. J., Boyd, H. A., Crisponi, L., Demerath, E. W., van Duijn, C. M., Econs, M. J., Harris, T. B., Hunter, D. J., Loos, R. J., Ridker, P. M., Spector, T. D., Streeten, E. A., Stefansson, K., Thorsteinsdottir, U., Murabito, J. M., Murray, A., Brandt, H., Crawford, S., Crow, S., Fichter, M. M., Halmi, K. A., Johnson, C., La Via, M., Mitchell, J., Strober, M., Rotondo, A., Woodside, D. B., Keel, P., Lilenfeld, L., Plotnicov, K., Magistretti, P., Montgomery, G. W., Blackburn, H., Schork, N. J., Hinney, Anke, Kesselmeier, Miriam, Jall, Sigrid, Volckmar, Anna-Lena, Föcker, Manuel, Hebebrand, J, GCAN, WTCCC3, GIANT, EGG, Price Foundation Collaborative Group, Children’s Hospital of Philadelphia/Price Foundation, Cardiology, Vascular Medicine, ACS - Amsterdam Cardiovascular Sciences, ACS - Atherosclerosis & ischemic syndromes, Hinney, A, Kesselmeier, M, Jall, S, Volckmar, Al, Focker, M, Antel, J, Gcan, Wtccc3, Heid, Im, Winkler, Tw, Grant, Sfa, Giant, Manunta, P, Sfa, Grant, Egg, Guo, Y, Bergen, Aw, Kaye, W, Berrettini, W, Hakonarson, H, Price Foundation Collaborative, Group, Children’s Hospital of Philadelphia/Price, Foundation, Herpertz-Dahlmann, B, de Zwaan, M, Herzog, W, Ehrlich, S, Zipfel, S, Egberts, Km, Adan, R, Brandys, M, van Elburg, A, Perica, Vb, Franklin, C, Tschop, Mh, Zeggini, E, Bulik, Cm, Collier, D, Scherag, A, Muller, Td, Animal Ecology, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, APH - Methodology, Volckmar, A-L, Föcker, M, Gcan, Wtccc, Gasparini, P, D'Adamo, A, Children’S Hospital of Philadelphia/Price, Foundation, Boraska Perica, V, Tschöp, Mh, and Müller, Td
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Netherlands Twin Register (NTR) ,Male ,Anorexia Nervosa ,Genome-wide association study ,Cardiovascular ,Linkage Disequilibrium ,Body Mass Index ,0302 clinical medicine ,Databases, Genetic ,WTCCC3 ,Aetiology ,Cancer ,0303 health sciences ,Loci ,Genetic Predisposition to Disease/genetics ,Cross-disorder ,Anorèxia nerviosa ,anorexia nervosa (AN) ,Shared ,3. Good health ,Psychiatry and Mental health ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,Human ,Alleles ,Body Weight ,Female ,Gene Frequency ,Genetic Loci ,Genetic Predisposition to Disease ,Genetic Variation ,Genome-Wide Association Study ,Humans ,Obesity ,Polymorphism, Single Nucleotide ,Risk Factors ,Molecular Biology ,Psychiatry and Mental Health ,Cellular and Molecular Neuroscience ,medicine.medical_specialty ,Locus (genetics) ,Single-nucleotide polymorphism ,ta3111 ,Article ,03 medical and health sciences ,Genetic ,SDG 3 - Good Health and Well-being ,Genetics ,EGG ,Polymorphism ,Children’s Hospital of Philadelphia/Price Foundation ,body mass index (BMI) ,genome-wide association meta-analysis (GWAMA) ,Prevention ,ta1184 ,medicine.disease ,030104 developmental biology ,Endocrinology ,diagnostic markers ,Body mass index ,Genètica ,030217 neurology & neurosurgery ,0301 basic medicine ,Linkage disequilibrium ,GIANT ,Medizin ,Obesity/genetics ,Overweight ,Medical and Health Sciences ,Oral and gastrointestinal ,Anorexia Nervosa/genetics ,2.1 Biological and endogenous factors ,Psychiatry ,2. Zero hunger ,Allele ,Eating disorder ,Single Nucleotide ,Biological Sciences ,Polymorphism, Single Nucleotide/genetics ,Price Foundation Collaborative Group ,Stroke ,psychiatric disorders ,Gene Frequency/genetics ,medicine.symptom ,Databases ,Internal medicine ,Body Weight/genetics ,medicine ,Journal Article ,Linkage Disequilibrium/genetics ,ddc:610 ,Metabolic and endocrine ,Nutrition ,030304 developmental biology ,GCAN ,business.industry ,Risk Factor ,Human Genome ,Psychology and Cognitive Sciences ,Bulimia nervosa ,business - Abstract
The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT). Subsequently we performed sex-stratified analyses for these 1000 SNPs. Functional ex vivo studies on four genes ensued. Lastly, a look-up of GWAMA-derived BMI-related loci was performed in the AN GWAMA. We detected significant associations (P-values
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- 2017
97. Utility of Genomic Testing after Renal Biopsy.
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Murray, Susan L., Dorman, Anthony, Benson, Katherine A., Connaughton, Dervla M., Stapleton, Caragh P., Fennelly, Neil K., Kennedy, Claire, McDonnell, Ciara A., Kidd, Kendrah, Cormican, Sarah M., Ryan, Louise A., Lavin, Peter, Little, Mark A., Bleyer, Anthony J., Doyle, Brendan, Cavalleri, Gianpiero L., Hildebrandt, Friedhelm, Conlon, Peter J., Murray, Susan L, and Benson, Katherine A
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RENAL biopsy ,FOCAL segmental glomerulosclerosis ,KIDNEY disease diagnosis ,GENETIC disorders ,GENETIC disorder diagnosis ,GENETIC testing ,NEPHRITIS - Abstract
Background: Renal biopsy is the mainstay of renal pathological diagnosis. Despite sophisticated diagnostic techniques, it is not always possible to make a precise pathological diagnosis. Our aim was to identify a genetic cause of disease in patients who had undergone renal biopsy and determine if genetic testing altered diagnosis or treatment.Methods: Patients with suspected familial kidney disease underwent a variety of next-generation sequencing (NGS) strategies. The subset of these patients who had also undergone native kidney biopsy was identified. Histological specimens were reviewed by a consultant pathologist, and genetic and pathological diagnoses were compared.Results: Seventy-five patients in 47 families underwent genetic sequencing and renal biopsy. Patients were grouped into 5 diagnostic categories based on pathological diagnosis: tubulointerstitial kidney disease (TIKD; n = 18); glomerulonephritis (GN; n = 15); focal segmental glomerulosclerosis and Alport Syndrome (n = 11); thrombotic microangiopathy (TMA; n = 17); and nonspecific pathological changes (n = 14). Thirty-nine patients (52%) in 21 families (45%) received a genetic diagnosis; 13 cases (72%) with TIKD, 4 (27%) with GN, 6 (55%) with focal segmental glomerulosclerosis/Alport syndrome, and 10 (59%) with TMA and 6 cases (43%) with nonspecific features. Genetic testing resulted in changes in understanding of disease mechanism in 21 individuals (54%) in 12 families (57%). Treatment would have been altered in at least 26% of cases (10/39).Conclusions: An accurate genetic diagnosis can result in changes in clinical diagnosis, understanding of pathological mechanism, and treatment. NGS should be considered as a complementary diagnostic technique to kidney biopsy in the evaluation of patients with kidney disease. [ABSTRACT FROM AUTHOR]- Published
- 2020
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98. Direct-Acting Oral Anticoagulants as Prophylaxis Against Thromboembolism in the Nephrotic Syndrome
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Sexton, Donal J., primary, de Freitas, Declan G., additional, Little, Mark A., additional, McHugh, Tomas, additional, Magee, Colm, additional, Conlon, Peter J., additional, and O’Seaghdha, Conall M., additional
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- 2018
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99. NPHP1 (Nephrocystin-1) Gene Deletions Cause Adult-Onset ESRD
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Snoek, Rozemarijn, primary, van Setten, Jessica, additional, Keating, Brendan J., additional, Israni, Ajay K., additional, Jacobson, Pamala A., additional, Oetting, William S., additional, Matas, Arthur J., additional, Mannon, Roslyn B., additional, Zhang, Zhongyang, additional, Zhang, Weijia, additional, Hao, Ke, additional, Murphy, Barbara, additional, Reindl-Schwaighofer, Roman, additional, Heinzl, Andreas, additional, Oberbauer, Rainer, additional, Viklicky, Ondrej, additional, Conlon, Peter J., additional, Stapleton, Caragh P., additional, Bakker, Stephan J.L., additional, Snieder, Harold, additional, Peters, Edith D.J., additional, van der Zwaag, Bert, additional, Knoers, Nine V.A.M., additional, de Borst, Martin H., additional, and van Eerde, Albertien M., additional
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- 2018
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100. Successful kidney transplantation normalizes platelet function
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Kennedy, Claire, primary, Wong, Limy, additional, Sexton, Donal J, additional, Cowman, Jonathan, additional, Oglesby, Irene, additional, Kenny, Martin, additional, Conlon, Peter J, additional, and Kenny, Dermot, additional
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- 2018
- Full Text
- View/download PDF
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