Search

Your search keyword '"Conradie, A."' showing total 7,334 results
Start Over Author "Conradie, A."

Refine your results

7,334 results on '"Conradie, A."'

60. Academia and industry agreement on a feasibility tool for first‐time‐in‐human clinical trial units

Author

Paloma Moraga, Paula Prieto, Almari Conradie, Majda Benhayoun, Vicki Rousell, Maria Davy, Uwe Fuhr, Rosa Antonijoan Arbos, Francisco Abad‐Santos, Antonio Portolés, Jolanda Van Duinen, Antonio J. Carcas, Alberto M. Borobia, and the ERA4TB Consortium

Subjects
Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270
Abstract

Abstract First‐time‐in‐human (FTIH) trials are designed to generate information on the safety, tolerability, as well as the pharmacokinetic and pharmacodynamics profile of new drugs. To ensure the safety of participants, these trials need to be conducted at specifically equipped phase I clinical trial units (CTUs). In accordance with the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) Guideline for Good Clinical Practice (GCP) and the European Union (EU) regulatory guidelines, one of the aims of the European Regime Accelerator for Tuberculosis (ERA4TB) project is to collaboratively create a feasibility tool, through a partnership between public and private entities, for the validation of CTUs selected to conduct FTIH trials. A feasibility form, encompassing nine sections, was created to gather information on the unit in relation to key attributes of FTIH trials. Collaboratively, industry and academic partners defined the minimal criteria to ensure the adherence of CTUs to the principles of ICH GCP and regulations outlined by the European Medicines Agency (EMA) for the execution of FTIH trials. Subsequently, all CTUs available for the project were assessed for FTIH trial eligibility. The introduction of the certification procedure through the feasibility tool within ERA4TB resulted in the accreditation of the five academic CTUs, which are now prepared to carry out FTIH trials as part of the Consortium. The developed feasibility tool aims to establish open and widely used minimum requirements for the validation of academic CTUs as FTIH units, marking it as the inaugural tool for CTU validation resulting from the collaboration between industry and academia within the ERA4TB project. The established partnership has enabled an innovative and novel way of working.

Published
2023
Full Text
View/download PDF

62. Proposed linezolid dosing strategies to minimize adverse events for treatment of extensively drug-resistant tuberculosis

Author

Imperial, Marjorie Z, Nedelman, Jerry R, Conradie, Francesca, and Savic, Rada M

Subjects
Patient Safety, Rare Diseases, Neurosciences, Tuberculosis, Clinical Research, Infectious Diseases, Hematology, Vaccine Related, Peripheral Neuropathy, Neurodegenerative, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Good Health and Well Being, Adult, Anemia, Antitubercular Agents, Extensively Drug-Resistant Tuberculosis, Humans, Linezolid, Peripheral Nervous System Diseases, Prospective Studies, Thrombocytopenia, Treatment Outcome, Tuberculosis, Multidrug-Resistant, adverse events, drug-resistant tuberculosis, linezolid, PK-PD modeling, tuberculosis therapeutics, PK–PD modeling, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundWe evaluated Nix-TB trial data (NCT02333799, N = 109) to provide dosing recommendations to potentially minimize linezolid toxicity in patients with extensively drug-resistant tuberculosis. .MethodsA pharmacokinetic model and toxicodynamic models for peripheral neuropathy, hemoglobin, and platelets were developed. Simulations compared safety outcomes for daily linezolid of 1200 and 600 mg, with and without dose adjustments for toxicity. Severe neuropathy was based on symptom scores from the Brief Peripheral Neuropathy Screen. Severe anemia and thrombocytopenia were defined as ≥ grade 3 adverse events according to the NIAID Division of Microbiology and Infectious Disease Adult Toxicity table.ResultsPredicted concentration-time profiles were a major predictor in all toxicodynamic models. Simulations showed higher percentages of patients with severe neuropathy (median, 19%; 90% confidence interval [CI], 17%-22% vs 5%, 4%-7%) and severe anemia (15%, 12%-17% vs 1%, 0%-2%) between 1200 and 600 mg daily linezolid. No differences in severe thrombocytopenia were observed (median, 10% decrease in hemoglobin level after 4 weeks of treatment would have maximum sensitivity (82%) and specificity (84%) for predicting severe anemia. Reducing the dose from 1200 to 600 mg triggered by this marker may prevent 60% (90% CI, 45%-72%) of severe anemia.ConclusionsSimple neuropathy symptom and hemoglobin monitoring may guide linezolid dosing to avoid toxicities, but prospective testing is needed to confirm the benefit-to-risk ratio.

Published
2022

63. Algorithmic correspondence for relevance logics, bunched implication logics, and relation algebras: the algorithm PEARL and its implementation (Technical Report)

Author

Conradie, Willem, Goranko, Valntin, and Jipsen, Peter

Subjects
Computer Science - Logic in Computer Science, Mathematics - Logic, 03B47, F.4.1
Abstract

The non-deterministic algorithmic procedure PEARL (an acronym for `Propositional variables Elimination Algorithm for Relevance Logic') has been recently developed for computing first-order equivalents of formulas of the language of relevance logics RL in terms of the standard Routley-Meyer relational semantics. It succeeds on a large class of axioms of relevance logics, including all so-called inductive formulas. In the present work we re-interpret PEARL from an algebraic perspective, with its rewrite rules seen as manipulating quasi-inequalities interpreted over Urquhart's relevant algebras, and report on its recent Python implementation. We also show that all formulae on which PEARL succeeds are canonical, i.e., preserved under canonical extensions of relevant algebras. This generalizes the "canonicity via correspondence" result in Urquhart's 1996 paper. We also indicate that, with minor modifications, PEARL can be applied to bunched implication algebras and relation algebras., Comment: 27 pages

Published
2021

70. Pragmatic cluster-randomized trial of home-based preventive treatment for TB in Ethiopia and South Africa (CHIP-TB)

Author

Malhotra, Akash, Nonyane, Bareng Aletta Sanny, Shirey, Evan, Mulder, Christiaan, Hippner, Piotr, Mulatu, Fiseha, Ratshinanga, Andani, Mitiku, Petros, Cohn, Silvia, Conradie, Gideon, Chihota, Violet, Chaisson, Richard E., Churchyard, Gavin J., Golub, Jonathan, Dowdy, David, Sohn, Hojoon, Charalambous, Salome, Bedru, Ahmed, and Salazar-Austin, Nicole

Published
2023
Full Text
View/download PDF

74. Exploring social indicators in smallholder food systems: modeling children’s educational outcomes on crop-livestock family farms in Madagascar

Author

Amy E. Thom, Jean-François Bélières, Beatrice Conradie, Paulo Salgado, Mathieu Vigne, and David Fangueiro

Subjects
rural development, smallholders, agri-food systems, policy guidance, sustainable development, social impacts analysis, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456
Abstract

Promoting smallholders’ sustainable development in Africa means addressing agronomic and economic factors but also highly relevant social influences shaping farmers’ production and affecting household well-being. Holistic, integrated analyses can help to meet this need, informing more effective policies and interventions for smallholder farming systems. The authors apply a transdisciplinary, quantitative approach to analyzing social impacts in the smallholder context, using milk-producing crop-livestock family farms in central Madagascar as a test case. First, stochastic frontier analysis is leveraged to confirm education as a social indicator linked to production efficiency. Then, linear regression is used for exploratory modeling of children’s educational outcomes. Findings from the Malagasy case emphasize the influence of rural infrastructure, parental education, chronic poverty, family planning, and crop-livestock diversification on children’s educational outcomes among one region’s farming households. Taken together, results suggest that Madagascar’s policymakers should consider comprehensive territorial planning for simultaneously promoting agricultural development and human well-being. This study illustrates how a transdisciplinary approach to social impacts analysis can integrate agronomic, economic, and social dynamics and help anticipate potential outcomes in support of smallholders’ sustainable development.

Published
2024
Full Text
View/download PDF

75. Obesity is South Africa’s new HIV epidemic

Author

Nomathemba Chandiwana, Willem Venter, Jennifer Manne-Goehler, Alisha Wade, Carel le Roux, Nzama Mbalati, Angelika Grimbeek, Petronell Kruger, Eunice Montsho, Zukiswa Zimela, Anele Yawa, Sibongile Tshabalala, Ndivhuwo Rambau, Ngqabutho Mpofu, Sasha Stevenson, Bridget McNulty, Ntobeko Ntusi, Yogan Pillay, Joel Dave, Angela Murphy, Sue Goldstein, Karen Hfman, Sameera Mahomedy, Elizabeth Thomas, Busi Mrara, Jeff Wing, Jeanne Lubbe, Zack Koto, Marli Conradie-Smit, Sean Wharton, Wayne May, Ian Marr, Hilton Kaplan, Mariam Forgan, Graham Alexander, John Turner, V R Fourie, Jocelyn Hellig, Mandy Banks, Kim Ragsdale, Marisa Noeth, Farzahna Mohamed, Landon Myer, Limakatso Lebina, Salome Maswime, Yunus Moosa, Sumy Thomas, Mzamo Mbelle, Phumla Sinxadi, Linda-Gail Bekker, Sindeep Bhana, June Fabian, Eric Decloedt, Zaheer Bayat, Reyna Daya, Bilal Bobat, Fiona Storie, Julia Goedecke, Kathleen Kahn, Stephen Tollman, Brett Mansfield, Mark Siedner, Vincent Marconi, Aaloke Mody, Ntombifikile Mtshali, Elvin Geng, Suman Srinivasa, Mohammed Ali, Samanta Lalla-Edwards, Alison Bentley, Gustaaf Wolvaardt, Andrew Hill, and Jeremy Nel

Subjects
Obesity, HIV, Healthy food, Medicine, Medicine (General), R5-920
Published
2024
Full Text
View/download PDF

76. Effective dyes for DSSCs–Important experimental and calculated parameters

Author

Jeanet Conradie

Subjects
DSSC performance, Dye, UV–vis, DFT, Renewable energy sources, TJ807-830, Agriculture (General), S1-972
Abstract

This review article gives a short overview of the basic principle and criteria to evaluate the performance of dye-sensitized solar cells. Experimental measurements such as the short-circuit current density, open-circuit photovoltage, fill factor, energy conversion efficiency, light harvesting energy and band gap, are discussed and formulas to measure them are provided. In addition, density functional theory calculated parameters often used to evaluate dyes for dye-sensitized solar cells are explained and formulated. These include light harvesting energy, oscillator strength, injection driving force, regeneration driving force, driving force for charge recombination, excited state lifetime, the character (e.g. metal based, ligand based, π, π* etc.) and energy of the highest occupied and lowest unoccupied molecular orbital, natural transition orbitals, band gap and reorganization energy for electron and hole. The relationship between the density functional theory calculated and experimentally measured parameters is explained. An enhanced short-circuit current density and improved performance of dye-sensitized solar cells are anticipated with higher calculated values for light harvesting efficiency, driving force for electron injection and regeneration, and lower calculated values of reorganization energy. Additionally, higher calculated values of the dipole moment of the dye perpendicular to the TiO2 semiconductor surface are expected to enhance the open-circuit photovoltage, consequently contributing to the overall performance of dye-sensitized solar cells. Figures to illustrate the different measurable parameters and selected examples from the literature are provided. These techniques can be employed in subsequent experimental and theoretical studies to validate potential new dyes for use in dye-sensitized solar cells.

Published
2024
Full Text
View/download PDF

77. A mindful approach to physician self-care

Author

Janine M. Kirby, Peter D. Milligan, Hofmeyr H. Conradie, and Belinda M. McIntosh

Subjects
self-care, burnout, systems failure, presence, perspective, self-compassion, Medicine
Abstract

There has been an increasing awareness of the importance of physician mental health. Several South African studies show a high prevalence of burnout among doctors. Burnout is characterised by three components: exhaustion, depersonalisation, and a sense of a lack of efficacy. Burnout is a result of both external and internal pressures. While lifestyle modification is essential, mindfulness-informed programmes promote self-regulation and resilience. Mindfulness programmes comprise three components: present moment awareness, perspective-taking and wisdom, and compassion. Physician wellness begins with individuals recognising the need of self-care and giving themselves permission to prioritise this. Ongoing identification of self-care needs and acting compassionately to address these needs is essential.

Published
2024
Full Text
View/download PDF

78. Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL

Author

Franz Koenig, Cécile Spiertz, Daniel Millar, Sarai Rodríguez-Navarro, Núria Machín, Ann Van Dessel, Joan Genescà, Juan M. Pericàs, Martin Posch, Adrian Sánchez-Montalva, Ana Belén Estevez, Àlex Sánchez, Anna Sanjuan, Elena Sena, Emma Granados, Esther Arévalo de Andrés, Fátima Nuñez, Gara Arteaga, Gabriela Perez Fuentes Ruiz, Guillermo Fernández, Jesus Rivera-Esteban, Joan Comella, Josep Antoni Ramos-Quiroga, Juan Espinosa, Juan Manuel Pericàs, Lada Murcia, Lucinda Cash-Gibson, Maria de Valles Silvosa, María Fernanda Barroso de Sousa, Olga Sánchez-Maroto Carrizo, Pol Ibañez-Jiménez, Salvador Augustin, Santiago Perez-Hoyos, Sergio Muñoz-Martínez, Silvia Serres, Susana Kalko, Amelie Michon, Anton Ussi, Ben Lydall, Edwin van de Ketterij, Ignacio Quiles, Tamara Carapina, Constantin Kumaus, Dariga Ramazanova, Elias Laurin Meyer, Marta Bofill Roig, Martin Brunner, Pavla Krotka, Sonja Zehetmayer, Charlotte Carton, Eric Legius, Amina Begum, Carmine Pariante, Courtney Worrell, Giulia Lombardo, Luca Sforzini, Mollie Brown, Nancy Gullet, Nare Amasi-Hartoonian, Rosalie Ferner, Melisa Kose, Andrea Spitaleri, Arash Ghodousi, Clelia Di Serio, Daniela Cirillo, Federica Cugnata, Francesca Saluzzo, Francesco Benedetti, Maria Giovanna Scarale, Michela Zini, Paola Maria Rancoita, Riccardo Alagna, Sara Poletti, Britt Dhaenens, Johan Van Der Lei, Jurriaan de Steenwinkel, Maxim Moinat, Rianne Oostenbrink, Witte Hoogendijk, Michael Hölscher, Norbert Heinrich, Christian Otte, Cornelia Potratz, Dario Zocholl, Eugenia Kulakova, Frank Tacke, Jelena Brasanac, Jonas Leubner, Maja Krajewska, Michaela Maria Freitag, Stefan Gold, Thomas Zoller, Woo Ri Chae, Christel Daniel, Leila Kara, Morgan Vaterkowski, Nicolas Griffon, Pierre Wolkenstein, Raluca Pais, Vlad Ratziu, David Voets, Christophe Maes, Dipak Kalra, Geert Thienpoint, Jens Deckerck, Nathan Lea, Peter Singleton, Kert Viele, Peter Jacko, Scott Berry, Tom Parke, Burç Aydin, Christine Kubiak, Jacques Demotes, Keiko Ueda, Mihaela Matei, Sergio Contrino, Claas Röhl, Estefania Cordero, Fiona Greenhalgh, Hannes Jarke, Juliana Angelova, Mathieu Boudes, Stephan Dressler, Valentina Strammiello, Quentin Anstee, Iñaki Gutierrez-Ibarluzea, Maximilian Otte, Natalie Heimbach, Benjamin Hofner, Cora Burgwinkel, Hue Kaestel, Katharina Hees, Quynh Nguyen, Daniel Prieto-Alhambra, Eng Hooi (Cheryl) Tan, Mario Raviglione, Pierpaolo de Colombani, Simone Villa, Eduard Maron, Gareth Evans, Adam J. Savitz, Anna Duca, Anne Kaminski, Bie Wouters, Brandon Porter, Catherine Charron, Cecile Spiertz, Christopher Zizzamia, Danny Hasselbaink, David Orr, Divya Kesters, Ellen Hubin, Emma Davies, Eva-Maria Didden, Gabriela Guz, Evelyn Verstraete, Gary Mao, George Capuano, Heddie Martynowicz, Heidi De Smedt, Ingela Larsson, Ines Bruegelmans, Isabelle Coste, Jesus Maria Gonzalez Moreno, Julia Niewczas, Jiajun Xu, Karin Rombouts, Katherine Woo, Kathleen Wuyts, Kathryn Hersh, Khrista Oldenburg, Lingjiao Zhang, Mark Schmidt, Mark Szuch, Marija Todorovic, Maartje Mangelaars, Melissa Grewal, Molli Sandor, Nick Di Prospero, Pamela Van Houten, Pansy Minnick, Polyana Bastos, Robert Patrizi, Salvatore Morello, Severijn De Wilde, Tao Sun, Timothy Kline, Tine de Marez, Tobias Mielke, Tom Reijns, Vanina Popova, Yanina Flossbach, Yevgen Tymofyeyev, Zeger De Groote, Alex Sverdlov, Alexandra Bobirca, Annekatrin Krause, Catalin Bobrica, Daniela Heintz, Dominic Magirr, Ekkehard Glimm, Fabienne Baffert, Federica Castiglione, Franca Caruso, Francesco Patalano, Frank Bretz, Guenter Heimann, Ian Carbarns, Ignacio Rodríguez, Ioana Ratescu, Lisa Hampson, Marcos Pedrosa, Mareile Hark, Peter Mesenbrink, Sabina Hernandez Penna, Sarah Bergues-Lang, Susanne Baltes-Engler, Tasneem Arsiwala, Valeria Jordan Mondragon, Hua Guo, Jose Leite Da Costa, Carl-Fredrik Burman, George Kirk, Anders Aaes-Jørgensen, Jorgen Dirach, Mette Skalshøi Kjær, Alexandra Martin, Diyan Hristov, Florent Rousseaux, Norbert Hittel, Robert Dornheim, Daniel Evans, Nick Sykes, Camille Couvert, Catherine Leuven, Loïc Notelet, Madhavi Gidh-Jain, Mathieu Jouannin, Nadir Ammour, Suzanne Pierre, Volker Haufe, Yingwen Dong, Catherine Dubanchet, Nathalie de Préville, Tania Baltauss, Zhu Jian, Sara Shnider, Tal Bar-El, Annette Bakker, Marco Nievo, Uche Iloeje, Almari Conradie, Ece Auffarrth, Leandra Lombard, Majda Benhayoun, Morounfolu Olugbosi, Stephanie S. Seidel, Berta Gumí, Claudia García Guzmán, Eva Molero, Gisela Pairó, Núria Machin, Raimon Cardelús, Saira Ramasastry, Saskia Pelzer, Andreas Kremer, Erno Lindfors, and Chris Lynch

Subjects
Adaptive designs, Master protocols, Patient-centred, Clinical research, Integrated research platform, Medicine (General), R5-920
Abstract

Summary: Platform trials bring the promise of making clinical research more efficient and more patient centric. While their use has become more widespread, including their prominent role during the COVID-19 pandemic response, broader adoption of platform trials has been limited by the lack of experience and tools to navigate the critical upfront planning required to launch such collaborative studies. The European Union-Patient-cEntric clinicAl tRial pLatform (EU-PEARL) initiative has produced new methodologies to expand the use of platform trials with an overarching infrastructure and services embedded into Integrated Research Platforms (IRPs), in collaboration with patient representatives and through consultation with U.S. Food and Drug Administration and European Medicines Agency stakeholders. In this narrative review, we discuss the outlook for platform trials in Europe, including challenges related to infrastructure, design, adaptations, data sharing and regulation. Documents derived from the EU-PEARL project, alongside a literature search including PubMed and relevant grey literature (e.g., guidance from regulatory agencies and health technology agencies) were used as sources for a multi-stage collaborative process through which the 10 more important points based on lessons drawn from the EU-PEARL project were developed and summarised as guidance for the setup of platform trials. We conclude that early involvement of critical stakeholder such as regulatory agencies or patients are critical steps in the implementation and later acceptance of platform trials. Addressing these gaps will be critical for attaining the full potential of platform trials for patients. Funding: Innovative Medicines Initiative 2 Joint Undertaking with support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

Published
2024
Full Text
View/download PDF

80. What, Exactly, Needs to Be Sustained Amidst a Changing Climate?

Author

Conradie, Ernst M., Fuller, Michael, Series Editor, Knutsson Brakenhielm, Lotta, Editorial Board Member, Bugajak, Grzegorz, Editorial Board Member, Evers, Dirk, Editorial Board Member, Harris, Mark, Editorial Board Member, Jackelén, Antje, Editorial Board Member, Karo, Roland, Editorial Board Member, Leach, Javier, Editorial Board Member, Meisinger, Hubert, Editorial Board Member, Oviedo, Lluis, Editorial Board Member, Revol, Fabien, Editorial Board Member, Sæther, Knut-Willy, Editorial Board Member, Uytterhoeven, Tom, Editorial Board Member, Leidenhag, Joanna, editor, and Runehov, Anne, editor

Published
2023
Full Text
View/download PDF

87. Surgical videos used for face-to-face and virtual oral assessment: experiences of examiners and trainees.

Author

K Baatjes, W Conradie, J M Edge, and E Archer

Subjects
Education, Education (General), L7-991, Medicine, Medicine (General), R5-920
Abstract

Background Varied assessment strategies are required in the process of deciding whether a surgeon is competent to graduate. Despite doubts about the reliability of the oral examination and the challenges of standardising examiner practices, it remains an important assessment method in surgical exit examinations. Structured orals may facilitate the measurement of course outcomes. Objectives This study explored the experiences of surgical trainees and examiners using a video-assisted, mock structured oral examination (SOE) as an assessment tool. Methods This descriptive study incorporated procedural videos in a case-based SOE format. One group of trainees had face-to-face contact with the examiner, and the other was assessed on an online platform, e.g., Microsoft Teams™, with a remote examiner. After the SOE, a focus group interview was conducted with surgical trainees and individual interviews with examiners. Results Themes were developed from the interview transcripts. These centred around the utility of videos in this examination format and technical issues during the SOE. Further themes highlighted the standardization of questions and preparation of examiners. Conclusion Overall, procedural videos as part of the mock SOE were experienced as valuable. Adding video recordings to the online platform posed administrative and technical challenges. However, the trainees and the examiners could log in from peripheral clinical training sites, which was experienced as an advantage. This study provides a glimpse into the application of procedural videos during SOEs as an assessment tool, from the perspective of surgical trainees and examiners. Efforts should focus on standardization of the examination format, optimizing technical issues, and improving examiner preparation.

Published
2023
Full Text
View/download PDF

88. Pragmatic cluster-randomized trial of home-based preventive treatment for TB in Ethiopia and South Africa (CHIP-TB)

Author

Akash Malhotra, Bareng Aletta Sanny Nonyane, Evan Shirey, Christiaan Mulder, Piotr Hippner, Fiseha Mulatu, Andani Ratshinanga, Petros Mitiku, Silvia Cohn, Gideon Conradie, Violet Chihota, Richard E. Chaisson, Gavin J. Churchyard, Jonathan Golub, David Dowdy, Hojoon Sohn, Salome Charalambous, Ahmed Bedru, and Nicole Salazar-Austin

Subjects
TB preventive treatment, TPT, Contact investigation, Household contact management, Pediatric TB, Pragmatic implementation trial, Medicine (General), R5-920
Abstract

Abstract Background Each year, 1 million children develop TB resulting in over 200,000 child deaths. TB preventive treatment (TPT) is highly effective in preventing TB but remains poorly implemented for household child contacts. Home-based child contact management and TPT services may improve access to care. In this study, we aim to evaluate the effectiveness and cost-effectiveness of home-based contact management with TPT initiation in two TB high-burden African countries, Ethiopia and South Africa. Methods This pragmatic cluster randomized trial compares home-based versus facility-based care delivery models for contact management. Thirty-six clinics with decentralized TB services (18 in Ethiopia and 18 in South Africa) were randomized in a 1:1 ratio to conduct either home-based or facility-based contact management. The study will attempt to enroll all eligible close child contacts of infectious drug-sensitive TB index patients diagnosed and treated for TB by one of the study clinics. Child TB contact management, including contact tracing, child evaluation, and TPT initiation and follow-up, will take place in the child’s home for the intervention arm and at the clinic for the control arm. The primary outcome is the cluster-level ratio of the number of household child contacts less than 15 years of age in Ethiopia and less than 5 years of age in South Africa initiated on TPT per index patient, comparing the intervention to the control arm. Secondary outcomes include child contact identification and the TB prevention continuum of care. Other implementation outcomes include acceptability, feasibility, fidelity, cost, and cost-effectiveness of the intervention. Discussion This implementation research trial will determine whether home-based contact management identifies and initiates more household child contacts on TPT than facility-based contact management. Trial registration NCT04369326 . Registered on April 30, 2020.

Published
2023
Full Text
View/download PDF

98. Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL

Author

Sánchez-Montalva, Adrian, Estevez, Ana Belén, Sánchez, Àlex, Sanjuan, Anna, Sena, Elena, Granados, Emma, Arévalo de Andrés, Esther, Nuñez, Fátima, Arteaga, Gara, Fuentes Ruiz, Gabriela Perez, Fernández, Guillermo, Rivera-Esteban, Jesus, Comella, Joan, Ramos-Quiroga, Josep Antoni, Genescà, Joan, Espinosa, Juan, Pericàs, Juan Manuel, Murcia, Lada, Cash-Gibson, Lucinda, de Valles Silvosa, Maria, Barroso de Sousa, María Fernanda, Sánchez-Maroto Carrizo, Olga, Ibañez-Jiménez, Pol, Augustin, Salvador, Perez-Hoyos, Santiago, Rodríguez-Navarro, Sarai, Muñoz-Martínez, Sergio, Serres, Silvia, Kalko, Susana, Michon, Amelie, Ussi, Anton, Lydall, Ben, van de Ketterij, Edwin, Quiles, Ignacio, Carapina, Tamara, Kumaus, Constantin, Ramazanova, Dariga, Meyer, Elias Laurin, Koenig, Franz, Roig, Marta Bofill, Brunner, Martin, Posch, Martin, Krotka, Pavla, Zehetmayer, Sonja, Carton, Charlotte, Legius, Eric, Begum, Amina, Pariante, Carmine, Worrell, Courtney, Lombardo, Giulia, Sforzini, Luca, Brown, Mollie, Gullet, Nancy, Amasi-Hartoonian, Nare, Ferner, Rosalie, Kose, Melisa, Spitaleri, Andrea, Ghodousi, Arash, Di Serio, Clelia, Cirillo, Daniela, Cugnata, Federica, Saluzzo, Francesca, Benedetti, Francesco, Scarale, Maria Giovanna, Zini, Michela, Rancoita, Paola Maria, Alagna, Riccardo, Poletti, Sara, Dhaenens, Britt, Van Der Lei, Johan, de Steenwinkel, Jurriaan, Moinat, Maxim, Oostenbrink, Rianne, Hoogendijk, Witte, Hölscher, Michael, Heinrich, Norbert, Otte, Christian, Potratz, Cornelia, Zocholl, Dario, Kulakova, Eugenia, Tacke, Frank, Brasanac, Jelena, Leubner, Jonas, Krajewska, Maja, Freitag, Michaela Maria, Gold, Stefan, Zoller, Thomas, Chae, Woo Ri, Daniel, Christel, Kara, Leila, Vaterkowski, Morgan, Griffon, Nicolas, Wolkenstein, Pierre, Pais, Raluca, Ratziu, Vlad, Voets, David, Maes, Christophe, Kalra, Dipak, Thienpoint, Geert, Deckerck, Jens, Lea, Nathan, Singleton, Peter, Viele, Kert, Jacko, Peter, Berry, Scott, Parke, Tom, Aydin, Burç, Kubiak, Christine, Demotes, Jacques, Ueda, Keiko, Matei, Mihaela, Contrino, Sergio, Röhl, Claas, Cordero, Estefania, Greenhalgh, Fiona, Jarke, Hannes, Angelova, Juliana, Boudes, Mathieu, Dressler, Stephan, Strammiello, Valentina, Anstee, Quentin, Gutierrez-Ibarluzea, Iñaki, Otte, Maximilian, Heimbach, Natalie, Hofner, Benjamin, Burgwinkel, Cora, Kaestel, Hue, Hees, Katharina, Nguyen, Quynh, Prieto-Alhambra, Daniel, Tan, Eng Hooi (Cheryl), Raviglione, Mario, de Colombani, Pierpaolo, Villa, Simone, Maron, Eduard, Evans, Gareth, Savitz, Adam J., Van Dessel, Ann, Duca, Anna, Kaminski, Anne, Wouters, Bie, Porter, Brandon, Charron, Catherine, Spiertz, Cecile, Zizzamia, Christopher, Millar, Daniel, Hasselbaink, Danny, Orr, David, Kesters, Divya, Hubin, Ellen, Davies, Emma, Didden, Eva-Maria, Guz, Gabriela, Verstraete, Evelyn, Mao, Gary, Capuano, George, Martynowicz, Heddie, De Smedt, Heidi, Larsson, Ingela, Bruegelmans, Ines, Coste, Isabelle, Gonzalez Moreno, Jesus Maria, Niewczas, Julia, Xu, Jiajun, Rombouts, Karin, Woo, Katherine, Wuyts, Kathleen, Hersh, Kathryn, Oldenburg, Khrista, Zhang, Lingjiao, Schmidt, Mark, Szuch, Mark, Todorovic, Marija, Mangelaars, Maartje, Grewal, Melissa, Sandor, Molli, Di Prospero, Nick, Van Houten, Pamela, Minnick, Pansy, Bastos, Polyana, Patrizi, Robert, Morello, Salvatore, De Wilde, Severijn, Sun, Tao, Kline, Timothy, de Marez, Tine, Mielke, Tobias, Reijns, Tom, Popova, Vanina, Flossbach, Yanina, Tymofyeyev, Yevgen, De Groote, Zeger, Sverdlov, Alex, Bobirca, Alexandra, Krause, Annekatrin, Bobrica, Catalin, Heintz, Daniela, Magirr, Dominic, Glimm, Ekkehard, Baffert, Fabienne, Castiglione, Federica, Caruso, Franca, Patalano, Francesco, Bretz, Frank, Heimann, Guenter, Carbarns, Ian, Rodríguez, Ignacio, Ratescu, Ioana, Hampson, Lisa, Pedrosa, Marcos, Hark, Mareile, Mesenbrink, Peter, Penna, Sabina Hernandez, Bergues-Lang, Sarah, Baltes-Engler, Susanne, Arsiwala, Tasneem, Mondragon, Valeria Jordan, Guo, Hua, Da Costa, Jose Leite, Burman, Carl-Fredrik, Kirk, George, Aaes-Jørgensen, Anders, Dirach, Jorgen, Kjær, Mette Skalshøi, Martin, Alexandra, Hristov, Diyan, Rousseaux, Florent, Hittel, Norbert, Dornheim, Robert, Evans, Daniel, Sykes, Nick, Couvert, Camille, Leuven, Catherine, Notelet, Loïc, Gidh-Jain, Madhavi, Jouannin, Mathieu, Ammour, Nadir, Pierre, Suzanne, Haufe, Volker, Dong, Yingwen, Dubanchet, Catherine, de Préville, Nathalie, Baltauss, Tania, Jian, Zhu, Shnider, Sara, Bar-El, Tal, Bakker, Annette, Nievo, Marco, Iloeje, Uche, Conradie, Almari, Auffarrth, Ece, Lombard, Leandra, Benhayoun, Majda, Olugbosi, Morounfolu, Seidel, Stephanie S., Gumí, Berta, Guzmán, Claudia García, Molero, Eva, Pairó, Gisela, Machin, Núria, Cardelús, Raimon, Ramasastry, Saira, Pelzer, Saskia, Kremer, Andreas, Lindfors, Erno, Lynch, Chris, Spiertz, Cécile, Machín, Núria, and Pericàs, Juan M.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results