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57. Clonal Response to Ethanol of Proliferating Rat Hepatoma Cells in Vitro.

Author

Cook, Robert T. and Martin, Gail S.

Abstract

We have grown HTC cefls (ascites variant of Morris hepatoma 7288c) Hi spinner cultures in the presence of various concentrations of ethanol, both in short-term incubations and in chronically exposed cultures. In short-term exposures cell proliferation is decreased in a dose-related fashion, falling to approximately 25% of control values at 35 mM ethanol. tot reted cultures maintained at ethanol concentrations gradually increased to 17 mM, there is an initial decrease in proliferation followed by stabilization. Comparison of the growth patterns of ceHs chronically exposed to ethanol with the growth patterns of unctoned naive ceHs suggests the presence of both ethanol-sensitive and -resistant HTC cell clones. Preliminary cloning experiments have been successful in demonstrating that HTC clones do exist which have widely varying responses to ethanol. Clones have been isolated which are growth-inhibited by low concentrations of ethanol whereas others are resistant or even stimulated in the same concentration range. The critical differences between ethanol-sensitive and -resistant HTC cells are currently unknown, but the general phenomenon of clonal selection during chronic ethanol exposure is of interest in the pathogenesis of alcohol-related diseases. [ABSTRACT FROM AUTHOR]

Published
1986
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60. Chronic ethanol induces inhibition of antigen‐specific CD8+but not CD4+immunodominant T cell responses following Listeria monocytogenesinoculation

Author

Gurung, Prajwal, Young, Betty M., Coleman, Ruth A., Wiechert, Susan, Turner, Lucas E., Ray, Nancy B., Waldschmidt, Thomas J., Legge, Kevin L., and Cook, Robert T.

Abstract

Chronic ethanol consumption results in immunodeficiency. Previous work with chronic ethanol‐fed mice has shown reduced splenic weight and cellularity, including reduced numbers of CD8+T cells. However, antigen‐specific CD8+and CD4+T cell responses in chronic ethanol‐fed mice have been studied relatively little. We have used an attenuated Listeria monocytogenesstrain DPL 1942 (LM ΔactA) to inoculate mice and subsequently used CD4+and CD8+immunodominant peptides of LM to measure the CD4+and CD8+T cell responses after chronic ethanol exposure. We found no major differences between control and ethanol‐fed mice in the kinetics and persistence of antigen‐specific CD4+T cells in response to an immunodominant LM peptide, as measured by intracellular IFN‐γ staining. In contrast to CD4+responses, three methods of in vitro antigen presentation indicated that the primary response of CD8+T cells to several different epitopes was reduced significantly in mice chronically fed ethanol. Antigen‐specific CD8+T cells were also reduced in chronic ethanol‐fed mice during the contraction phase of the primary response, and memory cells evaluated at 29 and 60 days after inoculation were reduced significantly. BrdU proliferation assays showed that in vivo proliferation of CD8+T cells was reduced in ethanol‐fed mice, and IL‐2‐dependent in vitro proliferation of naive CD8+T cells was also reduced. In conclusion, these results suggest that antigen‐specific CD4+T cell responses to LM are affected little by chronic ethanol consumption; however, antigen‐specific CD8+T cell responses are reduced significantly, as are in vivo and in vitro proliferation. The reduction of antigen‐specific CD8+T cells may contribute strongly to the immunodeficiency caused by ethanol abuse.

Published
2009
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62. Effect of Chronic Erythropoietin Administration on Plasma Iron in Newborn Lambs

Author

Peters, Charles, Georgieff, Michael K., de Alarcon, Pedro A., Cook, Robert T., Burmeister, Leon F., Lowe, Lance S., and Widness, John A.

Abstract

Erythropoietin, the primary stimulator of erythropoiesis, represents an important potential therapy for the anemia of prematurity. Enhancement of the therapeutic benefit of recombinant human erythropoietin (rhEp) in very-low-birth-weight infants will require a better understanding of rhEp’s pharmacodynamic effects including its interaction with iron in stimulating erythropoiesis. The purpose of this study was to determine the effects of chronic rhEp administration on plasma iron levels and hematopoiesis using a twin lamb model. Nine pairs of twin lambs in which one twin was randomized to receive rhEp, and the other saline, were studied during a 1-week baseline and a subsequent 4- to 5-week treatment period. The effects of therapy on plasma iron levels and erythropoiesis were measured by integrating the areas under the concentration-time curves (AUC) of the study variables. During the rhEp treatment period, significantly greater negative daily AUCs were observed in the rhEp-treated lambs for plasma iron concentration (p = 0.0008), while significantly greater positive daily AUCs were observed for hemoglobin concentration (p = 0.04) and reticulocyte count (p = 0.02). In the rhEp-treated group, pretreatment iron concentrations were directly associated with the magnitude of the iron response during treatment such that the greater the pretreatment iron, the greater the daily AUC below the plasma iron concentration-time plot (r = ––0.66, p = 0.05). For the placebo-treated group, this association tended toward, but did not achieve, statistical significance (r = ––0.52, p = n.s.). These observations suggest that treatment of rapidly growing newborn lambs with rhEp results in increased iron utilization due to increased erythropoiesis and depends on iron status at the initiation of rhEp treatment. Use of the term neonatal lamb model offers advantages over studies in human infants for more detailed or invasive examinations of the interaction of iron and rhEp treatment.

Published
1996
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68. PELVIMETRY

Author

BEAN, WILLIAM J., primary, COOK, ROBERT T., additional, EAVENSON, LESTER W., additional, and BRISTOW, LOUIS J., additional

Published
1967
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70. Research Priorities for Alcoholism Treatment

Author

McCaul, Mary E., Monti, Peter M., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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71. The Search for a Rational Basis for Treatment Selection

Author

Mattson, Margaret E., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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72. Spirituality, Treatment, and Recovery

Author

Miller, William R., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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73. Brief Interventions and the Treatment of Alcohol Use Disorders : Current Evidence

Author

Fleming, Michael F., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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74. Alcohol and Psychiatric Comorbidity

Author

Cornelius, Jack R., Bukstein, Oscar, Salloum, Ihsan, Clark, Duncan, Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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75. Animal Models of Motivation for Drinking in Rodents with a Focus on Opioid Receptor Neuropharmacology

Author

Koob, George F., Roberts, Amanda J., Kieffer, Brigitte L., Heyser, Charles J., Katner, Simon N., Ciccocioppo, Roberto, Weiss, Friedbert, Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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76. Treatment of Tobacco Dependence in Alcoholics

Author

Hurt, Richard D., Patten, Christi A., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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77. Treatment for Alcohol-Related Problems: Special Populations: Research Opportunities

Author

Gomberg, Edith S. Lisansky, Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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78. The Status of Serotonin-Selective Pharmacotherapy in the Treatment of Alcohol Dependence

Author

Pettinati, Helen M., Kranzler, Henry R., Madaras, Julie, Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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79. Outcomes of Alcohol Treatment for Adolescents

Author

Brown, Sandra A., D’Amico, Elizabeth J., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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80. Advances in the Use of Naltrexone an Integration of Preclinical and Clinical Findings

Author

O’Malley, Stephanie S., Froehlich, Janice C., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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81. Acamprosate

Author

Mason, Barbara J., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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82. Alcoholics Anonymous and 12-Step Alcoholism Treatment Programs

Author

Humphreys, Keith, Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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83. The Community Reinforcement Approach

Author

Meyers, Robert J., Smith, Jane Ellen, Lash, Denise N., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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84. Involvement of Support Networks in Treatment

Author

Longabaugh, Richard, Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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85. Overview

Author

Fuller, Richard K., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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86. Behavioral and Cognitive-Behavioral Treatments for Alcoholism Research Opportunities

Author

Kadden, Ronald M., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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87. Psychotherapy and Motivational Enhancement

Author

Di Clemente, Carlo C., Haug, Nancy, Bellino, Lori, Whyte, Shannon, Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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88. Advances in Research Design and Analysis for Alcohol Treatment

Author

Stout, Robert L., Papandonatos, George, Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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89. Clinicians’ Impact on the Quality of Substance Use Disorder Treatment

Author

Najavits, Lisa M., Crits-Christoph, Paul, Dierberger, Amy, Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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90. Natural Resolution of Alcohol-Related Problems

Author

Tucker, Jalie A., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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91. Assessment of Alcoholic Patients Advances and Future Challenges

Author

Allen, John P., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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92. Biomarkers as Aids to Identification of Relapse in Alcoholic Patients

Author

Allen, John P., Anton, Raymond, Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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93. Research on Alcoholism Treatment

Author

Gordis, Enoch, Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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94. Overview

Author

Eckardt, Michael J., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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95. Overview

Author

Litten, Raye Z., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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96. Overview

Author

Allen, John P., Beard, James D., editor, Agarwal, Dharam P., editor, Ames, Genevieve M., editor, Anton, Raymond F., editor, Baraona, Enrique, editor, Borg, Stefan, editor, Chandler, L. Judson, editor, Cook, Robert T., editor, Crabbe, John, editor, Day, Nancy, editor, De Witte, Phillipe A.J., editor, Diamond, Ivan, editor, Dudek, Bruce D., editor, Edenberg, Howard J., editor, Eriksson, C.J. Peter, editor, Gonzales, Rueben A., editor, Goodlett, Charles R., editor, Gruol, Donna, editor, Hoek, Jan B., editor, Hoffman, Paula L., editor, Holder, Harold D., editor, Ishii, Hiromasa, editor, Kalant, Harold, editor, Mason, Barbara J., editor, Lieber, Charles S., editor, Messing, Robert O., editor, Mezey, Esteban, editor, Miles, Michael F., editor, Nordmann, Roger, editor, Riley, Edward P., editor, Russell, Marcia, editor, Saltz, Robert F., editor, Saunders, John B., editor, Schenker, Steven, editor, Sullivan, Edith V., editor, Vogel-Sprott, Muriel, editor, Wand, Gary S., editor, Galanter, Marc, editor, Begleiter, Henri, editor, Deitrich, Richard, editor, Gallant, Donald, editor, Gottheil, Edward, editor, Paredes, Alfonso, editor, Rothschild, Marcus, editor, Van Theil, David, editor, Lagressa, Dolly, editor, Allen, John P., editor, Fuller, Richard, editor, Litten, Raye, editor, Eckardt, Michael, editor, Mcaul, Mary, editor, and Monti, Peter, editor

Published
2002
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97. Chronic ethanol induces inhibition of antigen-specific CD8+ but not CD4+ immunodominant T cell responses following Listeria monocytogenes inoculation.

Author

Gurung P, Young BM, Coleman RA, Wiechert S, Turner LE, Ray NB, Waldschmidt TJ, Legge KL, and Cook RT

Subjects
Animals, Antigen Presentation, Antigens, Bacterial immunology, CD8-Positive T-Lymphocytes pathology, Cell Proliferation, Cells, Cultured, Cytokines biosynthesis, Female, Interferon-gamma immunology, Interferon-gamma physiology, Listeria monocytogenes immunology, Listeriosis pathology, Lymphocyte Activation, Mice, Mice, Inbred BALB C, T-Lymphocytes, Cytotoxic immunology, Th2 Cells immunology, Alcohol Drinking immunology, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, Ethanol pharmacology, Listeria monocytogenes physiology, Listeriosis immunology
Abstract

Chronic ethanol consumption results in immunodeficiency. Previous work with chronic ethanol-fed mice has shown reduced splenic weight and cellularity, including reduced numbers of CD8+ T cells. However, antigen-specific CD8+ and CD4+ T cell responses in chronic ethanol-fed mice have been studied relatively little. We have used an attenuated Listeria monocytogenes strain DPL 1942 (LM DeltaactA) to inoculate mice and subsequently used CD4+ and CD8+ immunodominant peptides of LM to measure the CD4+ and CD8+ T cell responses after chronic ethanol exposure. We found no major differences between control and ethanol-fed mice in the kinetics and persistence of antigen-specific CD4+ T cells in response to an immunodominant LM peptide, as measured by intracellular IFN-gamma staining. In contrast to CD4+ responses, three methods of in vitro antigen presentation indicated that the primary response of CD8+ T cells to several different epitopes was reduced significantly in mice chronically fed ethanol. Antigen-specific CD8+ T cells were also reduced in chronic ethanol-fed mice during the contraction phase of the primary response, and memory cells evaluated at 29 and 60 days after inoculation were reduced significantly. BrdU proliferation assays showed that in vivo proliferation of CD8+ T cells was reduced in ethanol-fed mice, and IL-2-dependent in vitro proliferation of naive CD8+ T cells was also reduced. In conclusion, these results suggest that antigen-specific CD4+ T cell responses to LM are affected little by chronic ethanol consumption; however, antigen-specific CD8+ T cell responses are reduced significantly, as are in vivo and in vitro proliferation. The reduction of antigen-specific CD8+ T cells may contribute strongly to the immunodeficiency caused by ethanol abuse.

Published
2009
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98. RSA 2004: combined basic research satellite symposium-mechanisms of alcohol-mediated organ and tissue damage: inflammation and immunity and alcohol and mitochondrial metabolism: at the crossroads of life and death session one: alcohol, cellular and organ damage.

Author

Hoek J, Thiele GM, Klassen LW, Mandrekar P, Zakhari S, Cook RT, Ray NB, Happel KI, Kolls JK, Kovacs EJ, and Szab G

Subjects
Animals, Antigen Presentation drug effects, Burns immunology, Cytokines biosynthesis, Dendritic Cells drug effects, Dendritic Cells physiology, Female, Humans, Listeriosis immunology, Lung immunology, Macrophages drug effects, Macrophages immunology, Male, Sex Characteristics, Tumor Necrosis Factor-alpha genetics, Ethanol toxicity, Immune System drug effects, Immunity, Innate drug effects, Inflammation etiology
Abstract

This article summarizes content proceedings of a satellite meeting held at the 2004 Research Society on Alcoholism Annual Scientific Meeting in Vancouver, Canada. The aim of the satellite conference was to facilitate the interaction of scientists investigating the mechanisms of alcohol-mediated organ or tissue damage, and enable the discussion and sharing of new ideas and concepts that may be common in each of the organs or tissues affected by chronic ethanol consumption. The original planned program on immunity was expanded to incorporate a session on a closely related topic "Alcohol and Mitochondrial Metabolism: At the Crossroads of Life and Death" organized by Dr. Jan Hoek and Dr. Sam Zakhari. The conference was arranged into four sessions: 1) Alcohol, Cellular and Organ Damage 2) Toll-like receptors and Organ Damage 3) Alcohol and Mitochondrial Metabolism: At the Crossroads of Life and Death and 4) Hepatitis virus and alcohol interactions in Immunity and Liver Disease. The keynote address was given by Dr. Bruce Beutler from the Scripps Institute on "TLRs in Inflammation and Immunity."The Combined Basic Research Satellite Symposium entitled, "Mechanisms of Alcohol-Mediated Organ and Tissue Damage: Inflammation and Immunity and Alcohol and Mitochondrial Metabolism: At the Crossroads of Life and Death" was convened at the 2004 Research Society on Alcoholism meeting in Vancouver, BC. Session One featured five speakers who discussed various aspects of the role of the immune system in initiating or exacerbating cellular and organ damage following alcohol consumption. The presentations were (1) Innate Immune responses of Alcohol-exposed mice and macrophage-like cells following infections with Listeria monocytogenes by Robert T. Cook 2) Alcohol, cytokines and host defense by Kyle Happel 3) Decreased antigen presentation and anergy induced by alcohol in myeloid dendritic cells by Pranoti Mandrekar 4) Transcriptional regulation of TNF-alpha in human monocytes by chronic ethanol: role of the cellular redox state by Jay Kolls 5) Estrogen and gender differences in inflammatory responses after alcohol and burn injury by Elizabeth Kovacs. This session highlighted the growing information on the role of pattern recognition molecules in alcohol-mediated tissue damage or dysfunction. The new techniques and ideas presented will be helpful in future studies in this area of research, and should result in some exciting avenues of study.

Published
2005
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