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522 results on '"Coosemans, W"'

59. F-086LUNG TRANSPLANTATION FOR CYSTIC FIBROSIS: A SINGLE-CENTRE 24-YEAR EXPERIENCE

Author

Pironet, Zoë, primary, Ceulemans, L., additional, Dupont, L., additional, Vos, R., additional, Proesmans, M., additional, De Boeck, K., additional, Neyrinck, A., additional, Schetz, M., additional, Pirenne, J., additional, Coosemans, W., additional, Decaluwe, H., additional, De Leyn, P., additional, Depypere, L., additional, Nafteux, P., additional, Van Veer, H., additional, Verleden, G.M., additional, and Van Raemdonck, D., additional

Published
2016
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61. Transplantation of Lungs Recovered from Donors After Euthanasia Results in Excellent Long-Term Outcome

Author

Van Raemdonck, D., primary, Neyrinck, A., additional, Van Cromphaut, S., additional, Verleden, S., additional, Vanaudenaerde, B., additional, Claes, D., additional, Degezelle, K., additional, Desschans, B., additional, Vos, R., additional, Dupont, L., additional, Coosemans, W., additional, Decaluwé, H., additional, Depypere, L., additional, Nafteux, P., additional, Van Veer, H., additional, De Leyn, P., additional, and Verleden, G.M., additional

Published
2016
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63. (1282) - Double-Lung versus Heart-Lung Transplantation for Pulmonary Hypertension - A Single-Center Experience

Author

Brouckaert, J., Verleden, S., Verbelen, T., De Leyn, P., Coosemans, W., Decaluwé, H., Depypere, L., Nafteux, P., Van Veer, H., Meyns, B., Rega, F., Van De Velde, M., Poortmans, G., Rex, S., Neyrinck, A., Van den Berghe, G., Schetz, M., Vlasselaers, D., Van Cleemput, J., Budts, W., Vos, R., Belge, C., Delcroix, M., Verleden, G.M., and Van Raemdonck, D.E.

Published
2018
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65. Prognostic value of the circumferential resection margin and its definitions in esophageal cancer patients after neoadjuvant chemoradiotherapy.

Author

Depypere, Lieven, Moons, J., Lerut, T., De Hertogh, G., Peters, C., Sagaert, X., Coosemans, W., Van Veer, H., and Nafteux, P.

Subjects
SURGICAL excision, ESOPHAGEAL cancer, CHEMORADIOTHERAPY, LYMPH nodes, MULTIVARIATE analysis
Abstract

The accepted importance of a positive circumferential resection margin (CRM) (defined as R1 in the TNM classification) is based on histopathology of the resection specimen obtained after primary surgery in esophageal cancer patients. The aim of this study is to look for the prognostic value of CRM after neoadjuvant chemoradiotherapy and to compare the clinical significance of a histologically CRM < 1 mm from the cut margin (Royal College of Pathologists definition of R1) to a positive cut margin (College of American Pathologists definition of R1) and to ≥1 mm margin (R0) resections in patients with ypT3-esophageal tumors after neoadjuvant chemoradiotherapy. Between 2000 and 2014, 458 patients who received esophagectomy after neoadjuvant chemoradiation therapy were selected. Overall (OS) and disease-free survival (DFS) were calculated by means of Kaplan-Meier curves and compared by Cox regression analysis. There were 163 (35.9%) patients who had a ypT3 tumor; in 118 (72.4%) resection was complete (R0). In 37 (22.7%) patients a CRM < 1 mm was found and 8 (4.9%) had a circumferential R1-resection. CRM involvement was inversely correlated with tumor regression grading, lymph node capsular involvement, and number of positive lymph nodes. On univariate analysis, no statistically significant difference was found between R0-resection and CRM < 1 mm (P = 0.103) for OS, but DFS showed a significant difference (P = 0.025). Circumferential R1-resections showed a significant difference compared to R0-resections for OS and DFS (both P = 0.002). In multivariate analysis, extracapsular lymph node involvement and circumferential R1-resection were withheld as independent prognosticators for OS, whereas extracapsular lymph node involvement, absence of regression on the primary tumor and circumferential R1-resection were withheld for DFS. After correcting for different variables in the multivariate model, CRM < 1 mm showed no statistical difference compared to R0-resections neither for OS nor for DFS. After neoadjuvant chemoradiotherapy, CRM is correlated with biological behavior of the tumor and with therapy response. Furthermore it is an independent prognosticator for OS and DFS. HoweverCRM<1mm itself is no independent prognosticator for OS nor DFS survival in multivariable analysis. These results suggest that the definition of R1-resection should be limited to true invasion of the section plane. [ABSTRACT FROM AUTHOR]

Published
2018
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70. Technical Advances in Mediastinal Surgery

Author

Bodner, J, Cohen, J, Coosemans, W, D'Amico, T, D'Andrilli, A, Daiel, V, Decaluwè, H, Decker, G, De Leyn, P, Go, T, Ippolito, E, Komanapalli, C, Krasna, M, Lerut, T, Macchiarini, P, Mancini, F, Mineo, Tc, Nafteux, P, Calvin, S, Pompeo, E, Van Raemdonck, D, Rendina, E, Sukumar, M, Tacconi, F, Venuta, F, Weissenbacher, A, Wright, C, Yim, A, and Zielinski, M

Subjects
Settore MED/21 - Chirurgia Toracica
Published
2010

71. Technical advances in mediastinal surgery. Preface

Author

Bodner, J, Cohen, J, Coosemans, W, D'Amico, T, D'Andrilli, A, Daiel, V, Decaluwè, H, Decker, G, De Leyn, P, Go, T, Ippolito, E, Komanapalli, C, Krasna, M, Lerut, T, Macchiarini, P, Mancini, F, Mineo, Tc, Nafteux, P, Calvin, S, Pompeo, E, Van Raemdonck, D, Rendina, E, Sukumar, M, Tacconi, F, Venuta, F, Weissenbacher, A, Wright, C, Yim, A, and Zielinski, M

Subjects
Mediastinoscopy, Settore MED/21 - Chirurgia Toracica
Published
2010

75. Baseline Factors Associated with insulin independence and metabolic control in islet cell transplants. Annual scientific meeting of the Belgian Transplantation Society (20.03.2008)

Author

Hilbrands, Robert, Huurman, V., Gillard, Pieter, Velthuis, J, Mathieu, Chantal, De Waele, Marc, Kaufman, Leonard, Movahedi, Babak, Coosemans, W, Ysebaert, D., Gorus, Frans, Roep, B., Pipeleers, Daniel, Keymeulen, Bart, Department of Embryology and Genetics, Biomedical Statistics and Informatics, Pathologic Biochemistry and Physiology, Institute for Clinical Research, and Medical Biochemistry

Subjects
surgical procedures, operative, otorhinolaryngologic diseases, islet cell
Abstract

Baseline Factors Associated with insulin independence and metabolic control in islet cell transplants. Annual scientific meeting of the Belgian Transplantation Society (20.03.2008)

Published
2008

77. Isolated local recurrence or solitary solid organ metastasis after esophagectomy for cancer is not the end of the road.

Author

Depypere, L., Lerut, T., Moons, J., Coosemans, W., Decker, G., Van Veer, H., De Leyn, P., and Nafteux, P.

Subjects
METASTASIS, CANCER relapse, ESOPHAGECTOMY, TREATMENT of esophageal cancer, CHEMORADIOTHERAPY
Abstract

Recurrent disease after esophagectomy bears an infaust prognosis, especially when multiple recurrences are present. But little is known about survival in patients with limited recurrence (solitary locoregional recurrence or solid organ metastasis). Herein, we report our experience with these subgroups. We analyzed 1754 consecutive patients surgically treated with curative resection for esophageal cancer and cancer of the gastroesophageal junction between 1990 and 2012. Seven subgroups were defined according to the recurrence type (locoregional vs. organ metastasis), the site of recurrence (abdominal, thoracic, cervical for lymph nodes and lung, liver, adrenals and others for organ metastasis) and also the number of lesions (one vs. multiple lymph node stations or organ metastasis) Of these groups; clinical isolated locoregional recurrence (ciLR) was defined as solitary lymph-node recurrence confined to one compartment (cervical, thoracic or abdominal, within or outside surgical dissection-field) at clinical staging. Clinical solitary solid organ metastasis (csSOM) was defined as metastasis in a resectable solid organ, i.e. liver, lung, brain or adrenal. Salvage therapies were grouped in five categories. Kaplan-Meier curves were used to calculate survival. Recurrent disease was observed in 766 patients (43.7%) with overall 5-year survival of 4.5% after diagnosis of recurrence. Fifty-seven patients (7.4%) showed ciLR and 110 (14.4%) csSOM. Median timeto-recurrence was 16.8 months in ciLR and 9.9 months in csSOM (P=0.0074). Survival is significantly improved compared to supportive therapy when local therapy is possible (P<0.0001). In 25 (15%) of ciLR or csSOM patients, surgical therapy with or without systemic therapy, yielded a 5-year survival of 49.9% (median 54.8 months) after diagnosis of recurrence. When surgery was impossible or contraindicated, the combination of chemoradiotherapy appeared to be superior to chemotherapy alone (respectively 27.0% vs. 4.6% 5-year survival) or radiotherapy alone (no 5-year survival). Recurrent disease after esophagectomy is a common problem with poor overall survival. However prolonged survival could be obtained in selected patients if the recurrent disease is limited to ciLR or csSOM, if surgery (+/- systemic therapy) can be performed. If not a combination of chemoradiotherapy seems to offer the second best option. Patients presenting with a ciLR or csSOM should be discussed in a dedicated multidisciplinary team meeting as to evaluate and define the place of salvage treatment which in well selected cases could offer a perspective of prolonged survival. [ABSTRACT FROM AUTHOR]

Published
2017
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79. Eilandjestransplantatie: huidige inzichten en toekomstperspectieven

Author

Bart Keymeulen, Lannoo, M., Gillard, P., Coosemans, W., Chantal Mathieu, Inwendige Geneeskundige Specialiteiten, Pathologische Biochemie en Fysiologie, Pathologie/moleculaire en cellulaire geneeskunde, Diabetes Pathologie & Therapie, and Artsen Diabeteskliniek

Subjects
transplantation
Abstract

Transplantatie van pancreaseilandjes is een van de meest beloftevolle behandelingen voor type-1-diabetespatiënten. Tot voor kort waren de resultaten van de overleving van eilandjesgreffen en het bekomen van insulineonafhankelijkheid bij deze auto-immune patiënten ontgoochelend. Enkele jaren geleden slaagde men in Edmonton (Canada) erin om meer dan 10 type-1-diabetespatiënten insulineonafhankelijk te maken na eilandjestransplantatie door gebruik te maken van nieuwe immunosuppressieve therapie. In het elan van deze studie zijn er momenteel wereldwijd transplantatieprogramma's opgestart om de mogelijkheden van deze therapie te exploreren. Problemen van beschikbaarheid van voldoende materiaal om te transplanteren en de nog steeds aanwezige noodzaak tot chronische immunosuppressie beperken momenteel de mogelijkheden van deze techniek. Basisonderzoek naar stamcellen als mogelijke bron van eilandjes, naar het ontwikkelen van xenotransplantatie en vooral naar het induceren van tolerantie in het immuunsysteem geeft nieuwe hoop dat deze techniek ooit op grote schaal zal kunnen toegepast worden.

Published
2004

83. CLIC: a Two-Beam Multi-TeV $e^{\pm}$ Linear Collider

Author

Delahaye, Jean-Pierre, Wilson, Ian, Assmann, R., Becker, F., Bossart, R., Braun, Hans-Heinrich, Burkhardt, H., Carron, G., Coosemans, W., Corsini, R., D'Amico, E., Doebert, S., Fartoukh, S., Ferrari, A., Geschonke, G., Godot, J.C., Groening, L., Guignard, G., Hutchins, S., Jeanneret, B., Jensen, E., Jowett, J., Kamitani, T., Millich, A., Pearce, Peter D., Perriollat, F., Pittin, R., Potier, R., Riche, A., Rinolfi, L., Risselada, T., Royer, P., Ruggiero, F., Schulte, D., Suberlucq, G., Syratchev, I., Thorndahl, L., Trautner, H., Verdier, A., Wuensch, Walter, Zhou, F., Zimmermann, F., and Napoly, O.

Subjects
Physics::Accelerator Physics, Accelerators and Storage Rings
Abstract

The CLIC study of a high-energy (0.5 - 5 TeV), high-luminosity (1034 - 1035 cm-2 sec-1) e+e- linear collider is presented. Beam acceleration using high frequency (30 GHz) normal-conducting structures operating at high accelerating fields (150 MV/m) significantly reduces the length and, in consequence, the cost of the linac. Using parameters derived from general scaling laws for linear colliders, the beam stability is shown to be similar to lower frequency designs in spite of the strong wake-field dependency on frequency. A new cost-effective and efficient drive beam generation scheme for RF power production by the so-called "Two-Beam Acceleration" method is described. It uses a thermionic gun and a fully-loaded normal-conducting linac operating at low frequency (937 MHz) to generate and accelerate the drive beam bunches, and RF multiplication by funnelling in compressor rings to produce the desired bunch structure. Recent 30 GHz hardware developments and CLIC Test Facility (CTF) results are described.

Published
2000

84. CLIC, a Multi-TeV e+ linear collider

Author

Delahaye, J P, Wilson, I, Bossart, R, Braun, HH, Carron, G, Coosemans, W, Corsini, R, D'Amico, E, Godot, JC, Guignard, G, Hutchins, S, Jensen, E, Millich, A, Pearce, P, Potier, JP, Riche, AJ, Rinolfi, L, Schulte, D, Suberlucq, G, Thorndahl, L, Valentini, Μ, Wuensch, W, Zimmermann, F, Napoly, O, Raubenheimer, T, Ruth, R, and Syratchev, I

Subjects
Accelerators and Storage Rings
Published
1999

85. The CLIC study of a multi-TeV e± linear collider

Author

Bossart, R, Braun, HH, Carron, G, Coosemans, W, Corsini, R, d’ Amico, TE, Godot, JC, Guignard, G, Hagel, J, Hutchins, S, Jensen, E, Luong, Μ, Millich, A, Pearce, P, P Potier, J, Riche, AJ, Rinolfi, L, Schulte, D, Suberlucq, G, Thorndahl, L, Valentini, Μ, Wilson, I, Wuensch, W, Raubenheimer, T, Ruth, R, and Syratchev, I

Subjects
Accelerators and Storage Rings
Published
1999

86. Abdominal Transplant Surgery and Transplant Coordination University Hospitals Leuven 1997-2007: an overview

Author

UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - MD/CHIR - Département de chirurgie, Pirenne, Jacques, Van Gelder, Franck, Aerts, Raymond, Monbaliu, Diethard, Van Hees, D., de Roey, J., Desschans, B., De Pauw, Luc, Coosemans, W., UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - MD/CHIR - Département de chirurgie, Pirenne, Jacques, Van Gelder, Franck, Aerts, Raymond, Monbaliu, Diethard, Van Hees, D., de Roey, J., Desschans, B., De Pauw, Luc, and Coosemans, W.

Abstract

The transplant surgery and transplant coordination department was created in 1997 to meet up with the demand of the growing abdominal transplant surgery and organ procurement activity at the University Hospitals in Leuven. Since then, the procurement activity has increased and is currently distributed within the University Hospital Gasthuisberg and a network of approximately 25 collaborative hospitals. The profile of the donors has changed with older donors and more co-morbidity factors (obesity, hypertension, etc.). This donor activity represents approximately 30% of the national donor pool. Over the last 10 years, more than 1100 kidneys, more than 500 livers, approximately 50 pancreas, and 5 intestines have been transplanted in both adults and children. One year survival equal to- or exceeding 90% has been achieved for all abdominal organs and this compares favorably with international registries. More than 40 multi-visceral transplants {liver in combination with abdominal (kidney, pancreas, intestine) or thoracic (heart, double lung, heart-lung) organs} have been performed with results equivalent to isolated liver transplants and very little immunological graft loss (probably due to the immunoprotective effect of the liver). A live donation program was started for the kidney (40 cases) and for the liver (10 cases) in adults and children and no surgical graft loss has been seen so far. Introduction of new machine perfusion systems (and development of donor protocols) has made it possible to restart a non-heart-beating donor program for kidney transplantation. Experimental demonstration that livers tolerate short periods of warm ischemia has also allowed to start liver transplantation from non-heart-beating donors. In the future, machine perfusion of livers, viability testing, and biological modulation are likely to widen the use of marginal livers for transplantation and improve the results. An immunomodulatory protocol proven in the lab to induce the development

Published
2008

87. The CLIC 30 GHz Two-Beam Test Accelerator

Author

Wilson, I, Wuensch, W, Coosemans, W, and Achard, C

Subjects
Accelerators and Storage Rings
Abstract

As part of the experimental effort to demonstrate the feasibility of the CLIC scheme, a 3 m long representative section of the CLIC accelerator has been constructed, installed in the CLIC Test Facility (CTF) and successfully commissioned with beam. Prototype 30 GHz components developed during the course of the CLIC study including accelerating structures, power generating transfer structures, and high power RF loads, have been successfully integrated with the micron-precision active alignment system, the vacuum system, the water cooling system, and the high power RF distribution system to produce a very compact two-beam test accelerator. This paper describes the layout and gives details of the important subsystems.

Published
1998

96. Outcome after Lung Transplantation Is Comparable between DCD and DBD

Author

Van Raemdonck, D., primary, Vanaudenaerde, B., additional, Verleden, S., additional, Ruttens, D., additional, Vos, R., additional, Dupont, L., additional, Delcroix, M., additional, Wuyts, W., additional, Yserbyt, J., additional, Neyrinck, A., additional, Coosemans, W., additional, Decaluwé, H., additional, De Leyn, P., additional, Nafteux, P., additional, Van Veer, H., additional, and Verleden, G.M., additional

Published
2013
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99. Liver transplantation using non-heart-beating donors: Belgian experience.

Author

UCL - MD/CHIR - Département de chirurgie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Monbaliu, Diethard, Van Gelder, F., Troisi, R., De Hemptinne, Bernard, Lerut, Jan, Reding, Raymond, de Ville de Goyet, Jean, Detry, O., De Roover, A, Honore, P., Donckier, V., Gelin, M., Ysebaert, D., Aerts, R., Coosemans, W, Pirenne, Jacques, UCL - MD/CHIR - Département de chirurgie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Monbaliu, Diethard, Van Gelder, F., Troisi, R., De Hemptinne, Bernard, Lerut, Jan, Reding, Raymond, de Ville de Goyet, Jean, Detry, O., De Roover, A, Honore, P., Donckier, V., Gelin, M., Ysebaert, D., Aerts, R., Coosemans, W, and Pirenne, Jacques

Abstract

Mortality on liver transplantation (OLT) waiting lists has increased dramatically. Until recently, non-heart-beating donors (NHBD) were not considered suitable for OLT, because of a higher risk of primary graft nonfunction (PNF) and biliary strictures. However, recent experimental/clinical evidence has indicated that NHBD-OLT is feasible when the period of warm ischemia is short. PURPOSE: To characterize the results of NHBD-OLT in Belgium, a survey was sent to all Belgian OLT centers. RESULTS: Between January 2003 and November 2005, 16 livers originating from NHBD were procured and transplanted. The mean donor age was 48.8 years, including 9 males and 7 females with mean time of stop-therapy to cardiac arrest being 18 minutes and from cardiac arrest to liver cold perfusion, 10.5 minutes. Mean recipient age was 52.2 years including 12 males and 4 females. Mean cold ischemia time was 7 hours 15 minutes. No PNF requiring re-OLT was observed. Mean post-OLT peak transaminase was 2209 IU/L, which was higher among imported versus locally procured grafts. Biliary complications occurred in 6 patients requiring re-OLT (n = 2), endoscopic treatment (n = 2), surgical treatment (n = 1), or left untreated (n = 1). These tended to be more frequent after prolonged warm ischemia. Graft and patient survivals were 62.5% and 81.3%, respectively, with a follow-up of 3 to 36 months. CONCLUSION: This survey showed acceptable graft/patient survivals after NHBD-LT. The NHBD-liver grafts suffered a high rate of ischemic injury and biliary complications and therefore should be used carefully, namely with no additional donor risk factors, lower risk recipients, and short cold/warm ischemia.

Published
2007

100. Septuagenarian and Octogenarian Donors Provide Excellent Liver Grafts for Transplantation

Author

Darius, T., primary, Monbaliu, D., additional, Jochmans, I., additional, Meurisse, N., additional, Desschans, B., additional, Coosemans, W., additional, Komuta, M., additional, Roskams, T., additional, Cassiman, D., additional, van der Merwe, S., additional, Van Steenbergen, W., additional, Verslype, C., additional, Laleman, W., additional, Aerts, R., additional, Nevens, F., additional, and Pirenne, J., additional

Published
2012
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