51. [Antidepressants and pain].
- Author
-
Eschalier A and Courteix C
- Subjects
- Adrenergic Uptake Inhibitors therapeutic use, Antidepressive Agents, Tricyclic therapeutic use, Humans, Neuralgia drug therapy, Neuronal Plasticity drug effects, Selective Serotonin Reuptake Inhibitors therapeutic use, Analgesics therapeutic use, Antidepressive Agents therapeutic use, Pain drug therapy
- Abstract
A balanced inhibition of both serotonin and norepinephrine reuptake is usually evoked to explain the analgesic action of tricyclic and SNRI antidepressants but other mechanisms able to modulate the chronic pain-induced neuroplasticity may occur. Fundamental and clinical experiments are necessary to confirm the traditional monoaminergic hypothesis, to improve the efficacy of SRI and to better define the criteria of choice of antidepressants. These could open on novel therapeutic approaches for the management of chronic neuropathic pains as, for example the medication combination.
- Published
- 2007