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52. Increased plasma levels of circPTP4A2 and circTLK2 are associated with stroke injury.

Author

Wang, Xingzhi, Zhang, Shenyang, Zhang, Zuohui, Zu, Jie, Shi, Hongjuan, Yu, Lu, Lv, Bingchen, Cui, Likun, Mao, Wenqi, Wu, Di, and Cui, Guiyun

Subjects
STROKE, ISCHEMIC stroke, CIRCULAR RNA, WOUNDS & injuries
Abstract

Objective: Accumulating studies have shown that circulating circular RNAs (circRNAs) represent novel biomarkers for many human diseases. We investigated whether plasma circPTP4A2 and circTLK2 levels are associated with stroke severity, infarct volume, stroke etiology, and functional outcome in acute ischemic stroke (AIS) patients. Methods: We applied quantitative real‐time PCR (qPCR) to measure plasma circPTP4A2 and circTLK2 levels of 236 AIS patients within 72 h of symptoms onset and 136 healthy controls. We further assessed the National Institutes of Health Stroke Scale (NIHSS), infarct size, the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification and the 90‐day modified Rankin scale (mRS) for each patient. Results: At admission, plasma circPTP4A2 and circTLK2 levels in patients with moderate to severe stroke were significantly higher compared to those with mild stroke. Logistic regression and receiver‐operating characteristic (ROC) curve analyses indicated that they might function as predictive biomarkers for moderate to severe stroke. We also observed a medium positive correlation between these two circRNAs and NIHSS. Plasma circPTP4A2 and circTLK2 levels were slight positively correlated with cerebral infarct volume only in anterior circulation infarction (ACI) patients. Levels of both circPTP4A2 and circTLK2 were closely related with large artery atherosclerosis (LAA) stroke. Moreover, changes within 7 days after admission in circPTP4A2 and circTLK2 were able to predict unfavorable clinical outcome 90 days after AIS. Interpretation: These results demonstrate that plasma circPTP4A2 and circTLK2 strongly correlated with severity, subtypes and prognosis of AIS, and they could serve as promising biomarkers. [ABSTRACT FROM AUTHOR]

Published
2023
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56. Age and Sex Affect Essential Tremor (ET) Plus: Clinical Heterogeneity in ET Based on the National Survey in China

Author

Sun, Qiying, primary, He, Runcheng, primary, Huang, Hongyan, primary, Cao, Hongmei, primary, Wang, Xuejing, primary, Liu, Hong, primary, Wang, Chunyu, primary, Lei, Lifang, primary, Wang, Puqing, primary, Cui, Guiyun, primary, Ma, Jianjun, primary, Gu, Ping, primary, An, Di, primary, Jia, Min, primary, Sun, Zhanfang, primary, Wu, Heng, primary, Lin, Jinsheng, primary, Tang, Jiayu, primary, Zhou, Xun, primary, Li, Mingqiang, primary, Zeng, Sheng, primary, Chen, Yase, primary, Yan, Xinxiang, primary, Guo, Jifeng, primary, Xu, Qian, primary, Liu, Zhenhua, primary, Shen, Lu, primary, Jiang, Hong, primary, Wu, Xinyin, primary, Xiao, Qin, primary, Chen, Haibo, primary, Xu, Yanming, primary, and Tang, Beisha, primary

Published
2022
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61. Comparative Analysis of Acute Levodopa Challenge Test and the Outcomes of Deep Brain Stimulation in Parkinson's Disease.

Author

Chen, Yusheng, Zu, Jie, Zhang, Wei, Xu, Chuanying, Cui, Guiyun, Cui, Chenchen, and Xiao, Qihua

Subjects
SUBTHALAMIC nucleus, DEEP brain stimulation, PARKINSON'S disease, BRAIN stimulation, DOPA, MUSCLE rigidity, COMPARATIVE studies
Abstract

Background We study the correlation between the preoperative levodopa challenge test and the efficacy of deep brain stimulation (DBS) surgery in Parkinson's disease (PD). Methods Fifty patients with PD who underwent DBS treatment in our hospital from October 2016 to October 2017 were enrolled in this study. Using the Unified Parkinson Disease Rating Scale-III (UPDRS-III) as an indicator, we analyzed the improvement in motor symptoms on the levodopa challenge test and by DBS surgery. We also discussed the correlation between the effects of the levodopa challenge test and DBS surgery. Results There was no correlation between the results of the levodopa challenge test and DBS surgery. There was a linear correlation between muscle rigidity and bradykinesia, whereas the linear correlation between other symptoms was weak. Conclusion The levodopa challenge test can be used as a screening tool for patients undergoing DBS surgery, and can predict the degree of improvement in muscle rigidity and bradykinesia surgery. However, the prediction of the degree of improvement of total motor symptoms is poor. [ABSTRACT FROM AUTHOR]

Published
2022
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62. Imaging Parameters Predict Recurrence After Transient Ischemic Attack or Minor Stroke Stratified by ABCD 2 Score

Author

Jing, Jing, primary, Suo, Yue, additional, Wang, Anxin, additional, Zuo, Yingting, additional, Jiang, Yong, additional, Liu, Liping, additional, Zhao, Xingquan, additional, Wang, Yilong, additional, Li, Zixiao, additional, Li, Hao, additional, Meng, Xia, additional, Wang, Yongjun, additional, Li, Jilai, additional, Wu, Jian, additional, Zhang, Mei, additional, He, Maolin, additional, Gong, Tao, additional, Ouyang, Quping, additional, Huang, Guang, additional, Yu, Fengchun, additional, Wang, Chenlong, additional, Zhang, Jinli, additional, Wu, Wenqing, additional, Wang, Yi, additional, Yu, Yaoyu, additional, Zhang, Meiyun, additional, An, Zhongping, additional, Liu, Junyan, additional, Shi, Wanying, additional, Lu, Baoquan, additional, Geng, Lijun, additional, Wang, Shujuan, additional, Zhang, Xu, additional, Liu, Ruifang, additional, Zhao, Fengli, additional, Lin, Jie, additional, Liu, Xinping, additional, Sun, Xuebing, additional, Li, Tianyuan, additional, Wang, Youming, additional, He, Xinxia, additional, Yuan, Weiqiang, additional, Dou, Ronghua, additional, Liu, Lihai, additional, Wang, Yanling, additional, Zhang, Junling, additional, Du, Haisong, additional, Wei, Yuqing, additional, Wang, Cunrui, additional, Wang, Limin, additional, Zou, Yu’an, additional, Chen, Xiaofei, additional, Hu, Fengyun, additional, Liu, Jinfeng, additional, Zhao, Lili, additional, He, Fanping, additional, Wang, Xingchen, additional, Zhao, Qingwei, additional, Li, Xiaohong, additional, Zhao, Jun, additional, Xia, Zhangyong, additional, Li, Hongjin, additional, Yan, Mingzong, additional, Zhang, Guiru, additional, Liang, Hui, additional, Liu, Yunlin, additional, Xu, Jun, additional, Wang, Runqing, additional, Han, Yuhui, additional, Meng, Xianghong, additional, Li, Mingzhen, additional, Wang, Ting, additional, Han, Xinsheng, additional, Zhang, Hongtian, additional, Ma, Congmin, additional, Xue, Wenjun, additional, Wang, Chun, additional, Fang, Yan, additional, Liu, Gexia, additional, Wang, Jianfeng, additional, Ma, Qiang, additional, Zheng, Wenxu, additional, Chi, Haitao, additional, Gao, Lianbo, additional, Zhou, Jin, additional, Chen, Huisheng, additional, Feng, Juan, additional, Xiao, Hongbo, additional, Xiao, Lijun, additional, Yang, Yi, additional, Li, Guozhong, additional, Zhu, Yulan, additional, Wang, Lihua, additional, Yang, Yindong, additional, Qiu, Xuerong, additional, Gong, Xuhai, additional, Chen, Guohua, additional, Peng, Xiaoxiang, additional, Liu, Qunhui, additional, Gong, Shiping, additional, Zhou, Hongbin, additional, Li, Haipeng, additional, You, Yong, additional, Lin, Jinsheng, additional, Xu, Yun, additional, Sheng, Lei, additional, Zhao, Heqing, additional, Zhuang, Aixia, additional, Ke, Kaifu, additional, Fang, Qi, additional, Dong, Zhengxie, additional, Cui, Guiyun, additional, Geng, Deqin, additional, Rong, Liangqun, additional, Shi, Junfeng, additional, Yu, Ming, additional, Geng, Yu, additional, Luo, Benyan, additional, Cai, Xueli, additional, Zhou, Jun, additional, Wu, Yi, additional, Tang, Weiguo, additional, Wang, Zhimin, additional, Chen, Yangmei, additional, Wang, Yanjiang, additional, Chen, Kangning, additional, Wu, Shizheng, additional, Bu, Wenguang, additional, Cheng, Xiaohua, additional, Lu, Zhengqi, additional, Xu, An’ding, additional, Yin, Jia, additional, Cai, Jifu, additional, Guo, Yi, additional, Wu, Jun, additional, Li, Lvli, additional, Pan, Li, additional, Wang, Yinzhou, additional, Wang, Ning, additional, Niu, Jianping, additional, Li, Qing, additional, Wang, Hong, additional, Li, Hongyan, additional, Zhang, Xiaoying, additional, Zhan, Liping, additional, Chen, Yongming, additional, Wang, Baojun, additional, Wu, Li’e, additional, Liu, Li, additional, Zhao, Yanru, additional, Wu, Yingchun, additional, Zhu, Runxiu, additional, Du, Yanhui, additional, Wen, Yongxia, additional, Tian, Ye, additional, Wu, Songdi, additional, Qu, Yongcai, additional, Wu, Yuncheng, additional, Liu, Jianren, additional, Dong, Qiang, additional, Bai, Qingke, additional, Zhao, Yuwu, additional, Chen, Xu, additional, He, Chaoming, additional, Ren, Lijie, additional, Qiu, Weiwen, additional, Yao, Shufang, additional, Sun, Xuwen, additional, Zhang, Hainan, additional, Li, Weirong, additional, Gao, Ligong, additional, Chen, Xianglin, additional, Li, Jianhua, additional, Shi, Qiuyan, additional, Wang, Yan, additional, Zhao, Mingzhi, additional, Zeng, Jinsheng, additional, Wang, Liping, additional, Wang, Wei, additional, Qiu, Feng, additional, Li, Zhaochen, additional, Zhao, Liang, additional, Chen, Tianbao, additional, Xia, Lei, additional, Yang, SuYun, additional, Han, Yazhou, additional, Liu, Liyan, additional, Wu, Xinxiao, additional, Jiang, Beihai, additional, Li, Lizhong, additional, Lou, Weidong, additional, Shen, Xiaoqian, additional, Zhang, Ping, additional, Lan, Weiming, additional, Zheng, Aihu, additional, Bai, Qifu, additional, Luan, Lifang, additional, Chen, Lin, additional, Yan, Liqing, additional, Wang, Yanxia, additional, Huang, Xuerong, additional, Chai, Xiangting, additional, Liu, Yanshu, additional, You, Liangjun, additional, Yang, Hongqin, additional, Li, Dongfang, additional, Wang, Huijuan, additional, Gui, Linying, additional, Wu, Aisheng, additional, Zhang, Jianling, additional, Wang, Dengling, additional, Zhang, Qinghua, additional, He, Yunhong, additional, Guo, Ruiyou, additional, Teng, Jijun, additional, and Lou, Ping, additional

Published
2021
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65. Clinical, Electrophysiological and Radiological Features of Nitrous Oxide-Induced Neurological Disorders

Author

Bao,Lei, Li,Qing, Li,Qingjie, Chen,Hao, Zhang,Ruixue, Shi,Hongjuan, and Cui,Guiyun

Subjects
Neuropsychiatric Disease and Treatment
Abstract

Lei Bao,* Qing Li,* Qingjie Li, Hao Chen, Ruixue Zhang, Hongjuan Shi, Guiyun Cui Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei BaoDepartment of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of ChinaTel/Fax +86 516 85802129Email baolei56@gmail.comPurpose: We summarized the clinical manifestations, laboratory and electrodiagnostic characteristics and magnetic resonance imaging (MRI) findings of nitrous oxide (N2O) abuse-induced neurological disorders.Patients and Methods: We retrospectively reviewed 33 patients with N2O abuse-induced neurological disorders and reported their demographic data, clinical manifestations, laboratory examinations, nerve conduction studies, together with spinal and brain MRI.Results: The most frequent clinical manifestations included numbness and weakness in the extremities and unspecified gait disturbance. Low serum vitamin B12 levels were found in 9 patients, andhigh homocysteine levels were noted in 27 patients. Nerve conduction studies showed a sensory-motor neuropathy. Sixteen patients showed bilateral high-intensity T2 signal within the posterior column on spinal MRI, andfour patients showed cerebral white matter lesions on brain MRI.Conclusion: N2O abuse has become a significant public health problem because of the severe neurological disorders related to chronic abuse. Clinical physicians should be aware of the toxic effects of N2O.Keywords: nitrous oxide, neurological disorders, subacute combined degeneration, neuropathy, vitamin B12

Published
2020

66. Surgery and Guillain-Barré Syndrome: A Single-Center Retrospective Study Focused on Clinical and Electrophysiological Subtypes

Author

Bao,Lei, Chen,Xueting, Li,Qingjie, Zhang,Ruixue, Shi,Hongjuan, and Cui,Guiyun

Subjects
Neuropsychiatric Disease and Treatment, bacterial infections and mycoses
Abstract

Lei Bao,* Xueting Chen,* Qingjie Li,* Ruixue Zhang, Hongjuan Shi, Guiyun Cui Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei BaoDepartment of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People’s Republic of ChinaTel/Fax +86 516 85802129Email baolei56@gmail.comBackground: Surgery-related Guillain-Barré syndrome (GBS) is often underestimated and sometimes difficult to diagnose. This study aimed to elucidate the clinical features and electrophysiological subtypes of post-surgical GBS.Methods: We retrospectively reviewed 17 patients who developed post-surgical GBS after a recent surgery between 2015 and 2019. Clinical characteristics, electrophysiological examinations, lumbar puncture results and prognosis were assessed. As controls, we selected 66 patients hospitalized with non-surgical GBS.Results: The median duration from the surgery to the onset of GBS symptoms was 16.0 days. The main types of surgeries preceding GBS were orthopedic, gastrointestinal and neurosurgery. Symmetrical distal limbs weakness was present in all 17 post-surgical GBS patients. The incidence of respiratory failure, autonomic dysfunction and muscle atrophy in post-surgical GBS patients was significantly higher than that in non-surgical GBS patients. Hughes Functional Grading Scale (HFGS) scores were also higher in the post-surgical GBS group both at the time of peak disease and 6 months after discharge. Electrophysiological studies revealed significant motor amplitudes reduction with relative preserved nerve conduction velocities and distal latencies, suggesting axonal subtypes of GBS.Conclusion: GBS should be considered in patients with rapidly progressive muscle weakness after surgery. Such patients often exhibit axonal subtypes of GBS with severe motor dysfunction, high risk of respiratory failure, and poor prognosis.Keywords: Guillain-Barre syndrome, post-surgical GBS, surgery, electrophysiology, axonal neuropathy

Published
2020

67. Additional file 2 of NOD1/RIP2 signalling enhances the microglia-driven inflammatory response and undergoes crosstalk with inflammatory cytokines to exacerbate brain damage following intracerebral haemorrhage in mice

Author

Wang, Miao, Xinchun Ye, Jinxia Hu, Qiuchen Zhao, Bingchen Lv, Weijing Ma, Weiwei Wang, Hanhan Yin, Hao, Qi, Zhou, Chao, Zhang, Tao, Weifeng Wu, Wang, Yan, Mingyue Zhou, Cong-Hui Zhang, and Cui, Guiyun

Abstract

Additional file 2: Figure S2. Inhibitors of JNK/P38 kinases and NF-κB sufficiently suppressed inflammatory factors following ICH. Levels of iNOS, TNF-α, and IL-1β protein (A) in the brain in ICH-induced mice that were treated with the indicated inhibitors (n=3 mice for each group; *P

Published
2020
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68. Additional file 1 of NOD1/RIP2 signalling enhances the microglia-driven inflammatory response and undergoes crosstalk with inflammatory cytokines to exacerbate brain damage following intracerebral haemorrhage in mice

Author

Wang, Miao, Xinchun Ye, Jinxia Hu, Qiuchen Zhao, Bingchen Lv, Weijing Ma, Weiwei Wang, Hanhan Yin, Hao, Qi, Zhou, Chao, Zhang, Tao, Weifeng Wu, Wang, Yan, Mingyue Zhou, Cong-Hui Zhang, and Cui, Guiyun

Abstract

Additional file 1: Figure S1. The optimal concentration of the NOD1 inhibitor ML130 and the RIP2 inhibitor GSK583 for suppressing the inflammatory response was 20 μM. (A) In hemin-induced BV2 cells, ML130 concentrations of 0, 10, 20, and 30 μM were employed to assess the optimal dose of ML130 in inhibiting NOD1 and iNOS expression (n=3 experiments for each group; *P

Published
2020
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71. An analysis of the clinical and imaging features of mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)

Author

Chen, Hao, primary, Hu, Qian, additional, Raza, Hafiz Khuram, additional, Chansysouphanthong, Thitsavanh, additional, Singh, Sandeep, additional, Rai, Pabitra, additional, Cui, Guiyun, additional, Zhang, Zuohui, additional, Ye, Xinchun, additional, Xu, Chuanying, additional, Liu, Yonghai, additional, and Jiang, Haiyang, additional

Published
2020
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74. Balance between affect and outcome control or face and behaviour control for better learning: evidence from Chinese engineering project team

Author

Yang, Suying, Cui, Guiyun, Abdal Noor, Bashar, and Lu, Shaokai

Abstract

AbstractExploitative learning and exploratory learning are of great significance to the survival and long-term development of an organization. The former refers to the improvement of existing knowledge, skills and paradigms. The latter refers to the search for new knowledge, technology and experience. Therefore, the dual learning equilibrium (balance between exploitative learning and exploratory learning) is very important. However, for the engineering project organization, due to the pressure of cost and time cycle assessment, the engineering project organization is often more inclined to exploitative learning rather than exploratory learning. Therefore, how to realize the dual learning equilibrium (balance between exploitative learning and exploratory learning) of engineering project organization has become an urgent problem to be solved. Through formal control structures (outcome control vs. behaviour control) and guanxi(affect vs. face) can get the information needed by organizational dual learning (exploratory learning vs. exploitative learning), but whether the balance (formal control structures vs. guanxi) is still an effective strategy to promote dual learning equilibrium (balance between exploratory learning and exploitative learning) is still lack of theoretical and empirical support. It was examined assumptions related to how dual learning equilibrium is influenced by Guanxiand formal control structures equilibrium in project partnerships. Practically, this paper investigates the extent to which distinct components of Guanxi(i.e., affect and face) are differentially and interactively associated with outcome and behavioural controls on influencing ambidextrous learning equilibrium. Survey data were collected from 221 construction project partnerships in China. The results showed that both of the affect and behavioural controls have a positive impact on the ambidextrous learning equilibrium. Besides, the equilibrium between formal control structures and Guanxican promote the ambidextrous learning equilibrium of the engineering project team. Compared with behavioural controls, the equilibrium between the affect and outcome controls has a stronger positive correlation with the ambidextrous learning equilibrium of the engineering project team. Compared with the outcome controls, the equilibrium of face and behavioural controls has a stronger positive correlation with the ambidextrous learning equilibrium of the engineering project team. However, the equilibrium between the affect and behavioural controls has no significant impact on the ambidextrous learning of the project team. On the whole, the two-pronged and balanced strategy is still effective for dual learning equilibrium, but it should avoid the balanced use of affect and behavioural controls. In addition, the affect plays a negative moderating role in the process of behavioural controls affecting ambidextrous learning equilibrium. Face plays a positive moderating role in the influence of formal control structures on ambidextrous learning equilibrium. These findings have important implications for firms hoping to facilitate the dual learning equilibrium in China and other countries.

Published
2022
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83. A Rare Case of Bilateral Vertebral Artery Dissection Associated with Essential Thrombocythemia.

Author

Raza, Hafiz Khuram, Jing, Jia, Chen, Hao, Zhu, Jienan, Zhang, Zuohui, Chansysouphanthong, Thitsavanh, Cui, Guiyun, Hua, Fang, Ye, Xinchun, Shi, Hongjuan, and Jiang, Haiyang

Subjects
VERTEBRAL artery dissections, THROMBOCYTOSIS, ETIOLOGY of stroke, DIFFERENTIAL diagnosis, THERAPEUTICS
Abstract

A young patient presented to our hospital with ischemic stroke. She underwent a routine blood test, head computed tomography (CT), brain magnetic resonance imaging, a bone marrow biopsy, and CT angiography. Her diagnosis was a bilateral vertebral artery dissection associated with essential thrombocythemia (ET). She was treated with antiplatelet therapy and a stent implantation. The association of bilateral vertebral artery dissection with ET is rare. An early diagnosis and timely management is key to the best outcome. [ABSTRACT FROM AUTHOR]

Published
2020
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84. Association of polymorphism in rs2736990 of the a-synuclein gene with Parkinson's disease in a Chinese population

Author

Pan, Fenghua, Ding, Haixia, Dong, Hairong, Ye, Min, Liu, Weiguo, Cui, Guiyun, Chen, Jiechun, Wu, Yanfeng, Wang, Hui, Dai, Xingzhen, Shi, Haicun, and Ding, Xinsheng

Subjects
Parkinson's disease -- Genetic aspects -- Research, Single nucleotide polymorphisms -- Research, Health
Abstract

Byline: Fenghua. Pan, Haixia. Ding, Hairong. Dong, Min. Ye, Weiguo. Liu, Guiyun. Cui, Jiechun. Chen, Yanfeng. Wu, Hui. Wang, Xingzhen. Dai, Haicun. Shi, Xinsheng. Ding Background and Objective: Previous genetic [...]

Published
2013

89. Therapy Effects of Bone Marrow Stromal Cells on Ischemic Stroke

Author

Ye, Xinchun, Hu, Jinxia, and Cui, Guiyun

Subjects
stomatognathic system, Article Subject, hemic and immune systems, cardiovascular diseases
Abstract

Stroke is the second most common cause of death and major cause of disability worldwide. Recently, bone marrow stromal cells (BMSCs) have been shown to improve functional outcome after stroke. In this review, we will focus on the protective effects of BMSCs on ischemic brain and the relative molecular mechanisms underlying the protective effects of BMSCs on stroke.

Published
2016
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92. Activated mGluR5 protects BV2 cells against OGD/R induced cytotoxicity by modulating BDNF-TrkB pathway

Author

Ye, Xinchun, primary, Yu, Lu, additional, Zuo, Dandan, additional, Zhang, Liang, additional, Zu, Jie, additional, Hu, Jinxia, additional, Tang, Jiao, additional, Bao, Lei, additional, Cui, Chengcheng, additional, Zhang, Ruixue, additional, Jin, Guoliang, additional, Zan, Kun, additional, Zhang, Zuohui, additional, Yang, Xinxin, additional, Shi, Hongjuan, additional, Zhang, Zunsheng, additional, Xiao, Qihua, additional, Liu, Yonghai, additional, Xiang, Jie, additional, Zhang, Xueling, additional, and Cui, Guiyun, additional

Published
2017
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93. Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse

Author

Ye, Xinchun, primary, Shen, Tong, additional, Hu, Jinxia, additional, Zhang, Liang, additional, Zhang, Yunshan, additional, Bao, Lei, additional, Cui, Chengcheng, additional, Jin, Guoliang, additional, Zan, Kun, additional, Zhang, Zuohui, additional, Yang, Xinxin, additional, Shi, Hongjuan, additional, Zu, Jie, additional, Yu, Ming, additional, Song, Chengjie, additional, Wang, Yulan, additional, Qi, Suhua, additional, and Cui, Guiyun, additional

Published
2017
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95. ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia

Author

Ye, Xinchun, primary, Zuo, Dandan, additional, Yu, Lu, additional, Zhang, Liang, additional, Tang, Jiao, additional, Cui, Chengcheng, additional, Bao, Lei, additional, Zan, Kun, additional, Zhang, Zuohui, additional, Yang, Xinxin, additional, Chen, Hao, additional, Tang, Hai, additional, Zu, Jie, additional, Shi, Hongjuan, additional, and Cui, Guiyun, additional

Published
2017
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99. Superficial siderosis of central nervous system with unknown cause: report of 2 cases and review of the literature.

Author

Chen, Hao, Raza, Hafiz Khuram, Jing, Jia, Ye, Xinchun, Zhang, Zuohui, Hua, Fang, and Cui, Guiyun

Subjects
CENTRAL nervous system, LITERATURE reviews, PYRAMIDAL tract, SPINAL cord, HEARING disorders
Abstract

Objective: To report 2 cases of superficial siderosis of central nervous system (SS-CNS) and a review of the literature. Methods: We have analyzed the clinical data and relevant features of two patients with SS-CNS who were presented with ataxia and slurred speech. Both patients undertook blood tests, lumbar puncture, head CT (computer tomography) scans, and brain and spinal cord magnetic resonance (MR) scans. In addition, the first patient also undewent enhanced susceptibility-weighted angiography (ESWAN) and the second patient undertook susceptibility weighted imaging (SWI) scan. We searched PubMed with the keywords superficial siderosis and superficial siderosis of central nervous system, and selected publications that seemed appropriate. Results: A neurological examination revealed bilateral sensorineural hearing impairment in both the patients. Their past history was not significant to identify hemorrhage. Brain MR scans demonstrated typical hypointensity rimming at the brain surface on T2 weighted images. The patients were diagnosed with SS-CNS. Conclusion: SS-CNS should be highly suspected in patients with progressive sensorineural hearing loss, ataxia, and signs of pyramidal tracts, and MR scans of brain and whole spinal cord should be undertaken to confirm the diagnosis. Advanced MRI techniques such as SWI and ESWAN are helpful in making the diagnosis of SS-CNS. The cause of hemorrhage is not identified in most cases. [ABSTRACT FROM AUTHOR]

Published
2019
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