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Key Points: Quality of life (QoL) in patients with recurrent acute rhinosinusitis (RARS) is understudied.QoL for RARS patients is similar to chronic rhinosinusitis patients, although objective disease severity is lower.QoL of RARS patients is similarly affected during active and inactive infection. [ABSTRACT FROM AUTHOR]

Background: Fewer than half of patients with major depressive disorder (MDD) respond to psychotherapy. Pre-emptively informing patients of their likelihood of responding could be useful as part of a patient-centered treatment decision-support plan. Methods: This prospective observational study examined a national sample of 807 patients beginning psychotherapy for MDD at the Veterans Health Administration. Patients completed a self-report survey at baseline and 3-months follow-up (data collected 2018–2020). We developed a machine learning (ML) model to predict psychotherapy response at 3 months using baseline survey, administrative, and geospatial variables in a 70% training sample. Model performance was then evaluated in the 30% test sample. Results: 32.0% of patients responded to treatment after 3 months. The best ML model had an AUC (SE) of 0.652 (0.038) in the test sample. Among the one-third of patients ranked by the model as most likely to respond, 50.0% in the test sample responded to psychotherapy. In comparison, among the remaining two-thirds of patients, <25% responded to psychotherapy. The model selected 43 predictors, of which nearly all were self-report variables. Conclusions: Patients with MDD could pre-emptively be informed of their likelihood of responding to psychotherapy using a prediction tool based on self-report data. This tool could meaningfully help patients and providers in shared decision-making, although parallel information about the likelihood of responding to alternative treatments would be needed to inform decision-making across multiple treatments. [ABSTRACT FROM AUTHOR]

Depression symptoms are key risk factors for suicide; however, older adults differ from younger adults in types of depression symptoms experienced and thus their risk factors for suicide. The present brief report investigated relations between different symptoms of depression and suicide risk and whether these relations are moderated by age. Participants were 944 community-dwelling adults (N = 512, M = 39) and older adults (N = 432, M = 66) from the United States recruited through Mechanical Turk. Participants completed self-report measures on depression symptoms and suicide risk. Age was found to moderate the relation between cognitive-affective and somatic symptoms and suicide risk. Younger age exacerbated the negative effects of these symptoms on suicide risk. The study is the first to investigate whether older adults differed from younger adults in the association between types of depression symptoms and suicide risk and found that the risk posed by cognitive-affective and somatic symptoms was greater for younger adults. [ABSTRACT FROM AUTHOR]

Verticillium dahliae is a soil‐borne, phytopathogenic fungus that causes Verticillium wilt in cotton. Salt tolerance of cotton plants suffering from Verticillium wilt was significantly improved, but the mechanism is unknown. In this study, we built a symbiont named Cotton≡VD by immersing cotton plant roots into Verticillium dahliae liquid for four days. This resulted in a strong interaction between hyphae and the cotton roots. Under NaCl treatment for 24 h, the Cotton≡VD displayed less leaf wilting and improved root growth compared with the control. Biochemical tests of SOD, POD and CAT showed significant overexpression in Cotton≡VD compared with CK. RNA‐seq data analysis of Cotton≡VD indicated a novel 'galactose metabolism pathway' in the KEGG database, in which two key genes, GolS2 and RFS5, were significantly differentially expressed. Symbiotic metabolites inositol galactosyl could be transformed into raffinose to scavenge free radicals and participate in plant osmotic regulation to alleviate salt stress in Cotton≡VD. Functional analysis indicated that silencing of the target gene GhRFS (RFS5) led to a decrease of raffinose content and salt tolerance as compared with CK. Cotton≡VD can significantly improve cotton seedling salt tolerance through improving raffinose content, providing new insights into the salt tolerance mechanism and new salt‐tolerant material in the future. [ABSTRACT FROM AUTHOR]

Hopelessness is associated with depression, physical illness, and mortality. It is a key risk factor for suicidality in later life. Limitations have been identified in available hopelessness assessment measures regarding their use with older adults. The current study describes the development and initial psychometric evaluation of a content-valid, self-report scale for late-life hopelessness (i.e. the Hopelessness Inventory for Later Life; HILL). A sample of 265 older adults (ages 60–99, M = 71.1, SD = 6.7) was recruited through a combination of in-person, online, and mailed solicitations. Participants completed a survey battery containing the preliminary HILL and measures of related constructs (e.g. depression, anxiety, suicide risk, social support) to examine its psychometric properties. Multiple analytic item selection strategies resulted in two viable versions of the scale: the HILL and the HILL-Shortened (HILL-S). Both exhibited strong item response characteristics and preliminary evidence of unidimensionality (via factor analysis), internal consistency (α =.96 and α =.89, respectively), and construct validity (via correlations with related constructs). Findings provide preliminary psychometric support for both the HILL and HILL-S. Advantages for use of the HILL and the HILL-S over existing measures of hopelessness are discussed. [ABSTRACT FROM AUTHOR]

Objective: Dementia-related anxiety is associated with general anxiety and depression, which are risk factors for suicidal ideation. Consequently, dementia-related anxiety may be associated with suicidal ideation. When faced with a negative event (e.g. developing dementia), individuals primarily employ monitoring or blunting styles of coping. The present study investigated whether dementia-related anxiety and coping styles were associated with suicidal ideation in adults and whether coping styles moderated the relation between dementia-related anxiety and suicidal ideation. Methods: Online Mturk participants (n = 330) completed the Miller Behavioral Style Scale, Dementia Worry Scale, and Patient Health Questionnaire-9. Suicidal ideation was assessed with the Patient Health Questionnaire. Results: Dementia-related anxiety and monitor/blunter coping styles were independently associated with suicidal ideation in a multiple logistic regression; coping styles did not moderate the relation between dementia-related anxiety and suicidal ideation. Discussion: Greater dementia-related anxiety and less use of monitoring coping style were associated with suicidal ideation. Interventions to decrease suicide risk may benefit from taking into account individual differences in dementia-related anxiety and coping styles. [ABSTRACT FROM AUTHOR]

Insomnia disorders affect up to 10% of adults and are associated with other health problems and poor quality of life. Cognitive Behavioral Therapy for Insomnia (CBT-I) is an effective treatment; however, its effectiveness is hindered by poor attendance and adherence to treatment recommendations. The present study sought to identify predictors of attendance and adherence in CBT-I. Participants were 108 adults with insomnia disorder. Participants were primarily female (71.3%), middle aged (mean age = 50.5), and Caucasian (92.6%). Demographic variables, physical health problems, Beck Anxiety Inventory, Center for Epidemiologic Studies Depression-Revised scale, and Insomnia Severity Index were used to predict attending three or more sessions and adherence to consistent bedtime and waketime. Higher age was associated with better attendance and less deviation in bed and wake times. Anxiety and depression symptoms were associated with less attendance, and depression was also associated with more deviation in waketimes. To promote better attendance and adherence in treatment, depression or anxiety symptoms should be addressed before or during CBT-I. Identifying and tailoring CBT-I treatments toward the needs of different age groups may also improve attendance and adherence. [ABSTRACT FROM AUTHOR]

Objectives: Visual impairment in older adults may increase risk for depression and suicide. Research suggests that giving support to others may be associated with lower depressive symptoms in older adults, but much of the research has been in non-clinical populations. Furthermore, there is limited research on giving support and suicide risk. Methods: Using a sample of older adults with vision-related diagnoses (N = 101), this study investigated the association between informal support giving (unpaid support given to family, friends, or neighbors) and formal support giving (volunteering) on depressive symptoms and suicidal ideation. Linear regressions examined the relation between support giving and depression, and logistic regressions examined the relation between support giving and suicidal ideation. Results: Greater informal support giving was related to lower likelihood of reported suicidal ideation (OR:.82, 95% CI:.68-.99, p =.04), whereas volunteer activity was not significantly related to suicidal ideation. Neither volunteer behavior nor informal support giving was related to depressive symptoms. Conclusions: Providing informal support was associated with lower likelihood of endorsing suicidal ideation in older adults with vision impairment. Clinical Implications: Informal support giving may be a target for decreasing suicidal ideation among older adults with health impairments. [ABSTRACT FROM AUTHOR]

Summary: Although efforts have been taken to exploit diversity for yield and quality improvements, limited progress on using beneficial alleles in domesticated and undomesticated cotton varieties is limited. Given the complexity and limited amount of genomic information since the completion of four cotton genomes, characterizing significant variations and haplotype block inheritance under artificial selection has been challenging. Here we sequenced Gossypium hirsutum L. cv CRI‐12 (the cotton variety with the largest acreage in China), its parental cultivars, and progeny cultivars, which were bred by the different institutes in China. In total, 3.3 million SNPs were identified and 118, 126 and 176 genes were remarkably correlated with Verticillium wilt, salinity and drought tolerance in CRI‐12, respectively. Transcriptome‐wide analyses of gene expression, and functional annotations, have provided support for the identification of genes tied to these tolerances. We totally discovered 58 116 haplotype blocks, among which 23 752 may be inherited and 1029 may be recombined under artificial selection. This survey of genetic diversity identified loci that may have been subject to artificial selection and documented the haplotype block inheritance and recombination, shedding light on the genetic mechanism of artificial selection and guiding breeding efforts for the genetic improvement of cotton. [ABSTRACT FROM AUTHOR]

Objective: Research suggests sleep disturbance plays a role in depression and risk for suicidal behavior (i.e., ideation, attempts, death by suicide). How sleep disturbance affects suicide risk is unclear and one's ability to perform activities of daily living (ADLs) may help explain this relation. This study examined associations between sleep problems, ADLs, and either depressive symptoms or suicide risk among older adults. We hypothesized that ADLs would mediate relations between sleep problems and depressive symptoms and suicide risk. Method: Participants (N = 134; age ≥65) were recruited through Amazon's Mechanical Turk. Participants completed questionnaires that assessed insomnia symptoms, nightmares, ADLs, depressive symptoms, and suicidal behaviors. Results: Nightmares were associated with depressive symptoms and suicide risk but not independently associated with ADLs. Insomnia symptoms were associated with depressive symptoms, suicide risk, and ADLs. ADLs mediated the relation between insomnia symptoms and depressive symptoms. The insomnia symptom--suicidal behavior relation and the nightmare--suicidal behavior relation were significantly mediated by a pathway containing ADLs and depressive symptoms. Discussion: ADLs help explain how insomnia symptoms and nightmares confer suicide risk among older adults, either independently or in association with depressive symptoms. Clinical Implications: Practitioners should attend to ADL performance when treating older adults with insomnia and depression. [ABSTRACT FROM AUTHOR]

An introduction to articles in the issue is presented on topics including the link between functional impairment and perceptions of thwarted belongingness and perceived burdensomeness in older adults, a safety plan strategy for use with older adults that targets major risk factors for suicide in late life, and a telephone-based intervention to address suicide risk among older veterans.